Tympanomastoid cholesterol granuloma: radiological and intraoperative findings of blood source connection.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
Tympanomastoid cholesterol granuloma: radiological and intraoperative findings of blood source connection.: Related Articles*Tympanomastoid cholesterol granuloma: radiological and intraoperative findings of blood source connection.* Eur Arch Otorhinolaryngol. 2015 ; Authors: Iannella G, Stasolla A, Pasquariello B, Re M, Magliulo G Abstract The hypothesis that the close contiguity between the cholesterol granulomas and some rich blood sources provided the trigger to the aggressive nature of tympanomastoid cholesterol granulomas has been recently reported. To corroborate this new e...περισσότερα »
Phosphodiesterase 4D gene polymorphisms in sudden sensorineural hearing loss.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
Phosphodiesterase 4D gene polymorphisms in sudden sensorineural hearing loss.: Related Articles*Phosphodiesterase 4D gene polymorphisms in sudden sensorineural hearing loss.* Eur Arch Otorhinolaryngol. 2015 ; Authors: Chien CY, Tai SY, Wang LF, Hsi E, Chang NC, Wang HM, Wu MT, Ho KY Abstract The phosphodiesterase 4D (PDE4D) gene has been reported as a risk gene for ischemic stroke. The vascular factors are between the hypothesized etiologies of sudden sensorineural hearing loss (SSNHL), and this genetic effect might be attributed for its role in SSNHL. We hypothesized that genet... περισσότερα »
A novel nasopharyngeal stent for the treatment of obstructive sleep apnea: a case series of nasopharyngeal stenting versus continuous positive airway pressure.
Alexandros G. SfakianakisστοHead and NeckΠριν από 5 δευτερόλεπτα
A novel nasopharyngeal stent for the treatment of obstructive sleep apnea: a case series of nasopharyngeal stenting versus continuous positive airway pressure.: Related Articles*A novel nasopharyngeal stent for the treatment of obstructive sleep apnea: a case series of nasopharyngeal stenting versus continuous positive airway pressure.* Eur Arch Otorhinolaryngol. 2015 Nov ; Authors: Traxdorf M, Hartl M, Angerer F, Bohr C, Grundtner P, Iro H Abstract The objective of the study was to investigate the first-night treatment success of a nasopharyngeal stent compared to standard nCPAP... περισσότερα »
Is neutrophil-lymphocyte ratio associated with the severity of allergic rhinitis in children?
Alexandros G. SfakianakisστοHead and NeckΠριν από 5 δευτερόλεπτα
Is neutrophil-lymphocyte ratio associated with the severity of allergic rhinitis in children?: Related Articles*Is neutrophil-lymphocyte ratio associated with the severity of allergic rhinitis in children?* Eur Arch Otorhinolaryngol. 2015 Nov ; Authors: Dogru M, Evcimik MF, Cirik AA Abstract Neutrophil lymphocyte ratio (NLR) could be an important measure of systemic inflammation. There is a lack of knowledge about the neutrophil-lymphocyte ratio in rhinitis. We aimed to determine the relationship between the clinical parameters of allergic rhinitis and NLR in children. 438 childr... περισσότερα »
Osteitis and chronic rhinosinusitis: a review of the current literature.
Alexandros G. SfakianakisστοHead and NeckΠριν από 5 δευτερόλεπτα
Osteitis and chronic rhinosinusitis: a review of the current literature.: Related Articles*Osteitis and chronic rhinosinusitis: a review of the current literature.* Eur Arch Otorhinolaryngol. 2015 Nov ; Authors: Leung N, Mawby TA, Turner H, Qureishi A Abstract Chronic rhinosinusitis is a common debilitating condition characterized by inflammation of the nose and paranasal sinuses. Osteitis is an associated finding but it is not clear whether it is cause or effect. This review will report on studies that have examined the role of osteitis in CRS, with the ultimate aim of clarifyin... περισσότερα »
Central Venous Catheterization: Are We Using Ultrasound Guidance?
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Central Venous Catheterization: Are We Using Ultrasound Guidance?: Objectives— To assess the self-reported frequency of use of ultrasound guidance for central venous catheterization by emergency medicine (EM) residents, describe residents’ perceptions regarding the use of ultrasound guidance, and identify barriers to the use of ultrasound guidance. Methods— A longitudinal cross-sectional study was conducted at 5 academic institutions. A questionnaire on the use of ultrasound guidance for central venous catheterization was initially administered to EM residents in 2007. The same qu... περισσότερα »
Should patients with laryngeal small cell neuroendocrine carcinoma receive prophylactic cranial irradiation?
Alexandros G. SfakianakisστοHead and NeckΠριν από 5 δευτερόλεπτα
Should patients with laryngeal small cell neuroendocrine carcinoma receive prophylactic cranial irradiation?: *Should patients with laryngeal small cell neuroendocrine carcinoma receive prophylactic cranial irradiation?* Eur Arch Otorhinolaryngol. 2015 Nov ; Authors: Coca-Pelaz A, Devaney KO, Rodrigo JP, Halmos GB, Strojan P, Mendenhall WM, Eisbruch A, Smee R, Kusafuka K, Rinaldo A, Ferlito A Abstract While small cell neuroendocrine carcinomas (SCNCs) most often arise in the lung, extrapulmonary SCNCs arise in a variety of locations-including the head and neck region. In particul... περισσότερα »
Endoscopic ultrasonic dacryocystorhinostomy: clinical profile and outcomes.
Alexandros G. SfakianakisστοHead and NeckΠριν από 5 δευτερόλεπτα
Endoscopic ultrasonic dacryocystorhinostomy: clinical profile and outcomes.: *Endoscopic ultrasonic dacryocystorhinostomy: clinical profile and outcomes.* Eur Arch Otorhinolaryngol. 2015 Nov ; Authors: Ali MJ, Singh M, Chisty N, Kamal S, Naik MN Abstract Ultrasonic endoscopic dacryocystorhinostomy (UEnDCR) is emerging alternative modality of managing nasolacrimal duct obstructions. The aim of this study was to report the clinical profile and outcomes with a UEnDCR with mitomycin C and silicone intubation. Prospective interventional case series performed on all consecutive patien... περισσότερα »
Parameters for novel incus replacement prostheses.
Alexandros G. SfakianakisστοHead and NeckΠριν από 5 δευτερόλεπτα
Parameters for novel incus replacement prostheses.: *Parameters for novel incus replacement prostheses.* Eur Arch Otorhinolaryngol. 2015 Nov ; Authors: Kaftan H, Böhme A, Martin H Abstract Prostheses replacing the incus in its normal position and equipped with two joints might transfer sound as effectively as the intact ossicular chain and allow adjustment to quasi-static pressure changes. A prerequisite for prostheses development is the access to dimensions and distances of the ossicular chain which are necessary to conceptualize shape and size. Fifteen cadaveric human temporal ...περισσότερα »
Comparison of two different steroid treatments with hyperbaric oxygen for idiopathic sudden sensorineural hearing loss.
Alexandros G. SfakianakisστοHead and NeckΠριν από 5 δευτερόλεπτα
Comparison of two different steroid treatments with hyperbaric oxygen for idiopathic sudden sensorineural hearing loss.: *Comparison of two different steroid treatments with hyperbaric oxygen for idiopathic sudden sensorineural hearing loss.* Eur Arch Otorhinolaryngol. 2015 Nov 4; Authors: Sevil E, Bercin S, Muderris T, Gul F, Kiris M Abstract The purpose of the study was to assess the efficacy of the association of intratympanic (IT) steroid and hyperbaric oxygen (HBO) therapy in patients presenting with idiopathic sudden sensorineural hearing loss (ISSNHL), and to compare this ... περισσότερα »
Supraglottoplasty as treatment of exercise induced laryngeal obstruction (EILO).
Alexandros G. SfakianakisστοHead and NeckΠριν από 5 δευτερόλεπτα
Supraglottoplasty as treatment of exercise induced laryngeal obstruction (EILO).: *Supraglottoplasty as treatment of exercise induced laryngeal obstruction (EILO).* Eur Arch Otorhinolaryngol. 2015 Nov 5; Authors: Mehlum CS, Walsted ES, Godballe C, Backer V Abstract Breathing difficulties during exertion may be caused by exercise-induced laryngeal obstruction (EILO). The diagnosis depends on visualization of the larynx during exercise, i.e. by continuous laryngoscopic exercise (CLE) test. In case of severe supraglottic collapse and pronounced symptoms during strenuous exertion, s...περισσότερα »
Expansion sphincter pharyngoplasty for the treatment of OSA: a systemic review and meta-analysis.
Alexandros G. SfakianakisστοHead and NeckΠριν από 5 δευτερόλεπτα
Expansion sphincter pharyngoplasty for the treatment of OSA: a systemic review and meta-analysis.: *Expansion sphincter pharyngoplasty for the treatment of OSA: a systemic review and meta-analysis.* Eur Arch Otorhinolaryngol. 2015 Nov 5; Authors: Pang KP, Pang EB, Win MT, Pang KA, Woodson BT Abstract This study seeks to determine the success rates of the expansion sphincter pharyngoplasty and its variants on the treatment of obstructive sleep apnea (OSA). Systematic review and meta-analysis. Two independent searches of MEDLINE, Google Scholar, Cochrane Library and Evidence Based ... περισσότερα »
Computed tomography-based training model for otoplasty.
Alexandros G. SfakianakisστοHead and NeckΠριν από 5 δευτερόλεπτα
Computed tomography-based training model for otoplasty.: *Computed tomography-based training model for otoplasty.* Eur Arch Otorhinolaryngol. 2015 Nov 6; Authors: Schneider G, Voigt S, Rettinger G Abstract Otoplasty for the correction of protruding ears is characterized by various techniques and a common and popular cosmetic procedure. For the surgeon, whether beginner or advanced, it is essential to understand the principles and master techniques for standard auricular deformities before applying further sophisticated methods, because a lot of complications and failures are caus...περισσότερα »
Functional outcomes after supracricoid laryngectomy: what do we not know and what do we need to know?
Alexandros G. SfakianakisστοHead and NeckΠριν από 5 δευτερόλεπτα
Functional outcomes after supracricoid laryngectomy: what do we not know and what do we need to know?: Related Articles*Functional outcomes after supracricoid laryngectomy: what do we not know and what do we need to know?* Eur Arch Otorhinolaryngol. 2015 Nov 6; Authors: Schindler A, Pizzorni N, Mozzanica F, Fantini M, Ginocchio D, Bertolin A, Crosetti E, Succo G Abstract Supracricoid laryngectomies (SCLs) are conservative organ-sparing surgical techniques for the treatment of selected T2-T4 laryngeal carcinomas. Although these procedures allow preserving the larynx and its functi...περισσότερα »
Numerical simulation of humidification and heating during inspiration in nose models with three different located septal perforations.
Alexandros G. SfakianakisστοHead and NeckΠριν από 5 δευτερόλεπτα
Numerical simulation of humidification and heating during inspiration in nose models with three different located septal perforations.: Related Articles*Numerical simulation of humidification and heating during inspiration in nose models with three different located septal perforations.* Eur Arch Otorhinolaryngol. 2015 Nov 6; Authors: Lindemann J, Reichert M, Kröger R, Schuler P, Hoffmann T, Sommer F Abstract Nasal septum perforations (SP) are characterized by nasal obstruction, bleeding and crusting. The disturbed heating and humidification of the inhaled air are important facto...περισσότερα »
Concomitant corticosteroid nasal spray plus antihistamine (oral or local spray) for the symptomatic management of allergic rhinitis.
Alexandros G. SfakianakisστοHead and NeckΠριν από 5 δευτερόλεπτα
Concomitant corticosteroid nasal spray plus antihistamine (oral or local spray) for the symptomatic management of allergic rhinitis.: Related Articles*Concomitant corticosteroid nasal spray plus antihistamine (oral or local spray) for the symptomatic management of allergic rhinitis.* Eur Arch Otorhinolaryngol. 2015 Nov 6; Authors: Feng S, Fan Y, Liang Z, Ma R, Cao W Abstract The purpose of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to compare the symptomatic management of corticosteroid nasal spray plus antihistamine (or... περισσότερα »
Cytological accuracy and radiological staging in patients with thyroid cancer in Glasgow.
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
Cytological accuracy and radiological staging in patients with thyroid cancer in Glasgow.: *Cytological accuracy and radiological staging in patients with thyroid cancer in Glasgow.* Eur Arch Otorhinolaryngol. 2015 Nov 7; Authors: Montgomery J, Hendry J, Van der Horst C, Hunter MA, MacKenzie K, Hilmi O Abstract To assess the accuracy of initial combined cytological accuracy and radiological staging of patients suspected of having thyroid malignancy with their final histopathology. Retrospective case series in a tertiary referral centre for head and neck malignancy. All patients ...περισσότερα »
Management of thyroid gland invasion in laryngeal and hypopharyngeal squamous cell carcinoma.
Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα
Management of thyroid gland invasion in laryngeal and hypopharyngeal squamous cell carcinoma.: *Management of thyroid gland invasion in laryngeal and hypopharyngeal squamous cell carcinoma.* Eur Arch Otorhinolaryngol. 2015 Nov 7; Authors: Arslanoğlu S, Eren E, Özkul Y, Ciğer E, Kopar A, Önal K, Etit D, Tütüncü GY Abstract The objective of this study was to determine the incidence of thyroid gland invasion in laryngeal and hypopharyngeal squamous cell carcinoma; and the association between clinicopathological parameters and thyroid gland invasion. Medical records of 75 patients w...περισσότερα »
Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells: Journal Name: Biological Chemistry Issue: Ahead of print Abstract A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-γ (IFN-γ) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-γ plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human melanoma lines and skin melanocyt...περισσότερα »
The importance of prefixes as sublexical cues for stress assignment during reading
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Prefixes Repel Stress in Reading Aloud: Evidence from Surface Dyslexia via Cortex *Source:*Cortex Author(s): Maria Ktori, Jeremy J. Tree, Petroula Mousikou, Max Coltheart, Kathleen Rastle This study examined the importance of prefixes as sublexical cues for stress assignment during reading aloud English disyllabic words. In particular, we tested the hypothesis that prefixes repel stress (Rastle & Coltheart, 2000) by investigating the likelihood with which patients with surface dyslexia assign second-syllable stress to prefixed words. Five such patients were presented with three types...περισσότερα »
Left hemisphere specialization for word reading
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
potentially causes, rather than results from, a left lateralized bias for high spatial frequency visual information via Cortex Publication date: November 2015 *Source:*Cortex, Volume 72 Author(s): Alexandra Ossowski, Marlene Behrmann There is considerable evidence showing that efficient visual word recognition relies on high spatial frequency (HSF) visual coding in the left posterior fusiform gyrus. But whether the bias for HSF in the left hemisphere (LH) causally contributes to the LH superiority for word recognition or possibly results from it remains unknown. To assess whether the... περισσότερα »
The link between language and action
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Movement priming of EEG/MEG brain responses for action-words characterizes via Cortex Publication date: Available online 6 November 2015 *Source:*Cortex Author(s): Giovanna Mollo, Friedemann Pulvermüller, O. Hauk Activation in sensorimotor areas of the brain following perception of linguistic stimuli referring to objects and actions has been interpreted as evidence for strong interpretations of embodied semantics. Although a large number of studies have demonstrated this “language-to-action” link, important questions about how activation in the sensorimotor system affects language per... περισσότερα »
Melatonin: A Potential Anti-Oxidant Therapeutic Agent for Mitochondrial Dysfunctions and Related Disorders
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Melatonin: A Potential Anti-Oxidant Therapeutic Agent for Mitochondrial Dysfunctions and Related Disorders: Rejuvenation Research , Vol. 0, No. 0. Author information Showkat Ahmad Ganie,1 Tanveer Ali Dar,1 Aashiq Hussain Bhat,1 Khalid B. Dar, 1 Suhail Anees,1Mohammad Afzal Zargar,2 and Akbar Masood2 1Department of Clinical Biochemistry, University of Kashmir Srinagar, India. 2Department of Biochemistry, University of Kashmir Srinagar, India. Address correspondence to: *Showkat Ahmad Ganie* *or Tanveer Ali Dar* *Department of Clinical Biochemistry* *University of Kashmir* *Srinagar, 190...περισσότερα »
Readout-segmented Echo-planar Imaging in the Evaluation of Sinonasal Lesions
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
: A Comprehensive Comparison of Image Quality in Single-shot Echo-planar Imaging via Magnetic Resonance Imaging Publication date: Available online 2 November 2015 *Source:*Magnetic Resonance Imaging Author(s): Menglong Zhao, Zhuang Liu, Yan Sha, Shenjiang Wang, Xinpei Ye, Yucheng Pan, Shaoyu Wang PurposeTo investigate the role of readout-segmented echo-planar imaging using parallel imaging and a two-dimensional (2D) navigator (RESOLVE) in the evaluation of sinonasal lesions and to qualitatively and quantitatively compare the image qualities of single-shot echo-planar imaging (SS-EPI) a... περισσότερα »
Volasertib combined with nintedanib in advanced solid tumors
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
A phase I, dose-escalation study of volasertib combined with nintedanib in advanced solid tumors: Background Volasertib is a potent and selective cell-cycle kinase inhibitor that induces mitotic arrest and apoptosis by targeting Polo-like kinases. This study determined the maximum tolerated dose (MTD) and pharmacokinetics of volasertib combined with nintedanib, a potent and orally bioavailable triple angiokinase inhibitor, in patients with advanced solid tumors. Patients and methods This open-label, dose-escalation trial recruited patients with advanced metastatic solid tumors foll... περισσότερα »
Development and validation of a nomogram to predict survival in incurable cachectic cancer patients on home parenteral nutrition
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Development and validation of a nomogram to predict survival in incurable cachectic cancer patients on home parenteral nutrition: Background The use of home parenteral nutrition (HPN) in incurable cancer patients is extremely varied across different countries and institutions. In order to assess the clinical impact implied, we previously conducted a survey of incurable cancer patients receiving HPN, which shows that survival was markedly affected by Karnofsky performance status (KPS), tumor spread, Glasgow prognostic score (GPS) and tumor site. The aim of this study was to develop a...περισσότερα »
Νab-Paclitaxel versus dacarbazine in chemotherapy-naïve patients with metastatic melanoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
A randomized, controlled phase III trial of nab-Paclitaxel versus dacarbazine in chemotherapy-naïve patients with metastatic melanoma: Background The efficacy and safety of *nab*-paclitaxel versus dacarbazine in patients with metastatic melanoma was evaluated in a phase III randomized, controlled trial. Patients and methods Chemotherapy-naïve patients with stage IV melanoma received *nab*-paclitaxel 150 mg/m2 on days 1, 8, and 15 every 4 weeks or dacarbazine 1000 mg/m2 every 3 weeks. The primary end point was progression-free survival (PFS) by independent radiologic review; the ...περισσότερα »
Maintenance rituximab after autologous stem cell transplantation in patients with mantle cell lymphoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Maintenance rituximab after autologous stem cell transplantation in patients with mantle cell lymphoma: Background High-dose therapy and autologous stem cell transplantation (ASCT) improves outcomes for patients with mantle cell lymphoma (MCL), but relapse ultimately occurs in most patients. Recently presented interim results from a phase III prospective trial suggest maintenance rituximab (MR) after ASCT for MCL improves progression-free survival (PFS). The maturation of these data and any benefit of MR on overall survival (OS) remain to be defined. Patients and methods In this re... περισσότερα »
Case Presentation: Catching central sleep apnea during titrations of an oral sleep appliance
Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 25 δευτερόλεπτα
By Mark Collins, DDS and James Collins Abstract Titration is often the most difficult component of dental sleep medicine and the methods used to verify titration vary between practitioners. However, the end results of titration should maximize the relief of subjective symptoms while striving to optimize objective outcomes. Epworth and Berlin Sleepiness Scales help practitioners assess and relieve subjective symptoms while pulse oximeters and home sleep testers (HST) help practitioners assess and optimize objective outcomes. Yet, most type III home sleep testers and pulse oximeter...περισσότερα »
Routine Coronary Calcium Scan Can Precisely Measure Vertebral Bone Density Without a Quantitative Calibration Phantom.
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 25 δευτερόλεπτα
Routine Coronary Calcium Scan Can Precisely Measure Vertebral Bone Density Without a Quantitative Calibration Phantom.: Objective: We aimed to assess accuracy and precision of quantitative computed tomography (QCT) and phantomless in thoracic bone mineral density (BMD) assessment using coronary artery calcium scan (CACS). Methods: A total of 513 subjects underwent CACS with a calibration phantom. The thoracic spine BMD and concentration of calcium hydroxyapatite in phantom rods, as well CT Hounsfield unit of both, were measured. The thoracic BMD and phantom-rods calcium concentration... περισσότερα »
Are Most Cancers Caused by Specific Risk Factors Acting on Tissues With High Underlying Stem Cell Divisions?
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 25 δευτερόλεπτα
A recent paper by Tomasetti and Vogelstein demonstrated a high correlation coefficient of 0.81 between estimated lifetime normal renewing cell (stem cell) divisions among tissues in the body and the lifetime cancer risk in that organ. This finding has been interpreted frequently to suggest that if two-thirds of cancers arise primarily through normal proliferation then environmental and hereditary factors combined could explain only one-third of cancers. Yet, the pool of dividing stem cells is what risk factors act upon; it is unlikely that risk factors and proliferation act complet... περισσότερα »
miRNAs as biomarkers of high-risk pancreatic cysts: a possible holy grail for the early detection of pancreatic cancer
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 25 δευτερόλεπτα
Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/1kmd4OZ via IFTTT
Unknown Organism on Washed Hand Print
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 25 δευτερόλεπτα
Unknown organism, possible Bacillus spp, seen on a hand print after hand washing. TSA plate was grown at 37 C for 24 hours then left at refrigerated temps for 4 weeks. Organism was a light brown and mat. The center of the growth was smooth with rhizoid like growth on the edges which were mucoid... from Infection via ola Kala on Inoreader http://ift.tt/1Y1bRuF via IFTTT
Unknown Organism seem on Washed Hand Print
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 25 δευτερόλεπτα
Unknown organism, possible yeast or Bacillus, seen on a hand print after hand washing. TSA plate was grown at 37 C for 24 hours then left at refrigerated temps for 4 weeks. Organism was light yellow and mucoid . There are numerous rings of growth (looks like layers of rope) with lobate margins.... from Infection via ola Kala on Inoreader http://ift.tt/1kIetPy via IFTTT
Unknown Organism Washed Hand
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 25 δευτερόλεπτα
Unknown organism, possible yeast, seen on a hand print after hand washing. TSA plate was grown at 37 C for 24 hours then left at refrigerated temps for 4 weeks. Organism was light yellow, mat in the center and mucoid towards the outside. There are several rings of growth with each ring havin... from Infection via ola Kala on Inoreader http://ift.tt/20IGis3 via IFTTT
Molecular armory or niche factors: virulence determinants of Corynebacterium species
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 25 δευτερόλεπτα
For successful colonization of a host, pathogenic bacteria are equipped with a plethora of proteins and other components, often designated as virulence factors. However, many of these factors are involved in general adaptation to ecological niches rather than being specific for interaction of a bacterial pathogen with a distinct host. Therefore, a designation of these components as niche factors was proposed. While originally developed for different species colonizing the gastro-intestinal tract, in this communication the concept of niche factors is discussed in respect to a singl... περισσότερα »
Diversity, antimicrobial and antioxidant activities of culturable bacterial endophyte communities in Aloe vera
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 25 δευτερόλεπτα
Twenty-nine culturable bacterial endophytes were isolated from surface-sterilized tissues (root, stem and leaf) of *Aloe vera* and molecularly characterized to 13 genera: *Pseudomonas*, *Bacillus*, *Enterobacter*, *Pantoea*, *Chryseobacterium*, *Sphingobacterium*, *Aeromonas*, *Providencia*, *Cedecea*, *Klebsiella*, *Cronobacter*, *Macrococcus* and *Shigella*. The dominant genera include *Bacillus* (20.7%), *Pseudomonas* (20.7%) and *Enterobacter* (13.8%). The crude and ethyl acetate fractions of the metabolites of six isolates, species of *Pseudomonas*, *Bacillus*, *Chryseobacter... περισσότερα »
Elevated guanosine 5'-diphosphate 3'-diphosphate level inhibits bacterial growth and interferes with FtsZ assembly
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 25 δευτερόλεπτα
FtsZ, a protein essential for prokaryotic cell division, forms a ring structure known as the Z-ring at the division site. FtsZ has a GTP binding site and is assembled into linear structures in a GTP-dependent manner *in vitro*. We assessed whether guanosine 5'-diphosphate 3'-diphosphate (ppGpp), a global regulator of gene expression in starved bacteria, affects cell division in *Salmonella* Paratyphi A. Elevation of intracellular ppGpp levels by using the *relA* expression vector induced repression of bacterial growth and incorrect FtsZ assembly. We found that FtsZ forms helical s... περισσότερα »
Chronic Intermittent Hypoxia and Blood Pressure
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Chronic Intermittent Hypoxia and Blood Pressure: Is There Risk for Hypertension in Healthy Individuals?: High Altitude Medicine & Biology , Vol. 0, No. 0. Author information Denis Vinnikov,1 Nurlan Brimkulov,2 and Viktor Krasotski3 1Public Association “Lung Health,” Bishkek, Kyrgyzstan. 2Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan. 3Kumtor Gold Company, Bishkek, Kyrgyzstan. Address correspondence to: *Denis Vinnikov, MD, PhD* *Public Association “Lung Health”* *Akhunbaev Street 92* *Bishkek, 720020* Kyrgyzstan *E-mail:* denisvinnikov@mail.ru ABSTRACT Vinnikov, Denis, Nurlan ... περισσότερα »
Headache and Depression in Patients with Hypothalamic-pituitary Disorders-etiology and Risk Factors
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Headache and Depression in Patients with Hypothalamic-pituitary Disorders-etiology and Risk Factors: Exp Clin Endocrinol Diabetes 2015; 123: 571-574 DOI: 10.1055/s-0035-1559630 Introduction: Headache and depression are common problems in patients with hypothalamic-pituitary disorders (HPD). Aim: To determine the prevalence of headache and depression in patients with HPD and the specific characteristics in affected individuals in comparison to patients with cardiovascular problems (CD). Methods: Patients with HPD and CD were asked to complete a questionnaire regarding headache and de...περισσότερα »
Inferior rectus nasal transposition for superior oblique palsy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Inferior rectus nasal transposition for superior oblique palsy: Kaza H, Warkad VU *DOI* http://dx.doi.org/10.2147/OPTH.S79482 *Checked for plagiarism* Yes *Review by* Single-blind *Peer reviewer comments* 3 *Editor who approved publication: *Professor Scott Fraser Mana Okamoto, Akiko Kimura, Akiko Masuda, Osamu Mimura Department of Ophthalmology, Hyogo College of Medicine Hospital, Nishinomiya, Japan *Abstract:* Nasal transposition of the inferior rectus (IR) muscle, which is transposed nasally with the insertion parallel to the spiral of Tillaux, could correct excyclotropia. How... περισσότερα »
Effects of Needle and Catheter Size on Commercially Available Ultrasound Contrast Agents
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Effects of Needle and Catheter Size on Commercially Available Ultrasound Contrast Agents: Objectives— To investigate effects of needle and catheter size on in vitro ultrasound contrast agent (UCA) enhancement and concentrations using 4 commercially available UCAs. Methods— Definity (Lantheus Medical Imaging, North Billerica, MA), Optison (GE Healthcare, Princeton, NJ), SonoVue (Bracco SA, Geneva, Switzerland), and Sonazoid (GE Healthcare, Oslo, Norway) were investigated. The UCA was injected via a 1-mL syringe (BD, Franklin Lakes, NJ) into a 3-way stopcock (Smith Medical, Dublin, ... περισσότερα »
Acoustic Properties of Breast Fat
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Acoustic Properties of Breast Fat: Objectives— The American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) atlas for ultrasound (US) qualitatively describes the echogenicity and attenuation of a mass, where fat lobules serve as a standard for comparison. This study aimed to estimate acoustic properties of breast fat under clinical imaging conditions to determine the degree to which properties vary among patients. Methods— Twenty-four women with solid breast masses scheduled for biopsy were scanned with a Siemens S2000 scanner and 18L6 linear array transduce...περισσότερα »
Abdominal Muscle Thickness and Maximal Expiratory Pressure
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Correlation Between Abdominal Muscle Thickness and Maximal Expiratory Pressure: Objectives— The activity of abdominal muscles mainly produces high expiratory pressure. These include the rectus abdominis, external oblique, internal oblique, and transverse abdominis muscles. The purpose of this study was to determine whether maximal expiratory pressure is associated with each abdominal muscle thickness at rest. Methods— Thirty-nine healthy male volunteers (mean age ± SD, 20.7 ± 2.7 years) participated in the study. The thickness of the right rectus abdominis, external oblique, inter...περισσότερα »
Chronic Influences of Obstructive Sleep Apnea on Cerebral Venous Flow
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Chronic Influences of Obstructive Sleep Apnea on Cerebral Venous Flow: Objectives— Evidence reveals a pathophysiologic link between sleep apnea syndrome and cerebrovascular diseases. It is known that obstructive sleep apnea (OSA) may cause serial hemodynamic changes and structural abnormalities in the cerebral and cardiac arterial systems, but its effect on the cerebral venous system has remained unclear. The purpose of this study was to compare internal jugular vein hemodynamics between patients with OSA and healthy individuals. Methods— Patients with OSA and age-, body mass inde... περισσότερα »
Classification of Benign and Malignant Thyroid Nodules Using Wavelet Texture Analysis of Sonograms
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Classification of Benign and Malignant Thyroid Nodules Using Wavelet Texture Analysis of Sonograms: Objectives— The purpose of this study was to evaluate a computer-aided diagnostic system using texture analysis to improve radiologic accuracy for identification of thyroid nodules as malignant or benign. Methods— The database comprised 26 benign and 34 malignant thyroid nodules. Wavelet transform was applied to extract texture feature parameters as descriptors for each selected region of interest in 3 normalization schemes (default, μ ± 3, and 1%–9%). Linear discriminant analysis an...περισσότερα »
Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signaling
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Abstract Angiogenesis denotes the formation of new blood vessels from pre-existing vasculature. Progression of diseases such as cancer and several ophthalmological disorders may be promoted by excess angiogenesis. Novel therapeutics to inhibit angiogenesis and diagnostic tools for monitoring angiogenesis during therapy, hold great potential for improving treatment of such diseases. We have previously generated so-called biparatopic Affibody constructs with high affinity for the vascular endothelial growth factor receptor-2 (VEGFR2), which recognize two non-overlapping epitopes in ... περισσότερα »
Augmented Indian hedgehog signaling in cranial neural crest cells leads to craniofacial abnormalities and dysplastic temporomandibular joint in mice
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Abstract Extensive studies have pinpointed the crucial role of Indian hedgehog (Ihh) signaling in the development of the appendicular skeleton and the essential function of Ihh in the formation of the temporomandibular joint (TMJ). In this study, we have investigated the effect of augmented Ihh signaling in TMJ development. We took a transgenic gain-of-function approach by overexpressing *Ihh* in the cranial neural crest (CNC) cells using a conditional *Ihh* transgenic allele and the *Wnt1-Cre* allele. We found that *Wnt1-Cre*-mediated tissue-specific overexpression of *Ihh* in the... περισσότερα »
VEGFA splicing: divergent isoforms regulate spermatogonial stem cell maintenance
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Abstract Despite being well-known for regulating angiogenesis in both normal and tumorigenic environments, vascular endothelial growth factor A (VEGFA) has been recently implicated in male fertility, namely in the maintenance of spermatogonial stem cells (SSC). The *VEGFA* gene can be spliced into multiple distinct isoforms that are either angiogenic or antiangiogenic in nature. Although studies have demonstrated the alternative splicing of VEGFA, including the divergent roles of the two isoform family types, many investigations do not differentiate between them. Data concerning VE...περισσότερα »
RANKL regulates differentiation of microfold cells in mouse nasopharynx-associated lymphoid tissue (NALT)
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Abstract Murine nasopharynx-associated lymphoid tissue (NALT), located at the base of the nasal cavity, serves as a major site for the induction of mucosal immune responses against airway antigens. The follicle-associated epithelium (FAE) covering the luminal surface of NALT is characterized by the presence of microfold cells (M cells), which take up and transport luminal antigens to lymphocytes. Glycoprotein 2 (GP2) has recently been identified as a reliable marker for M cells in Peyer's patches of the intestine. However, the expression of GP2 and other functional molecules in th... περισσότερα »
Involvement of phosphoinositide 3-kinase class IA (PI3K 110α) and NADPH oxidase 1 (NOX1) in regulation of vascular differentiation induced by vascular endothelial growth factor (VEGF) in mouse embryonic stem cells
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Abstract The impact of reactive oxygen species and phosphoinositide 3-kinase (PI3K) in differentiating embryonic stem (ES) cells is largely unknown. Here, we show that the silencing of the PI3K catalytic subunit *p110α* and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 (*NOX1*) by short hairpin RNA or pharmacological inhibition of NOX and ras-related C3 botulinum toxin substrate 1 (Rac1) abolishes superoxide production by vascular endothelial growth factor (VEGF) in mouse ES cells and in ES-cell-derived fetal liver kinase-1+ (Flk-1+) vascular progenitor cells, wher... περισσότερα »
Hoxc13 is a crucial regulator of murine hair cycle
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Abstract Hair follicles undergo cyclical growth and regression during postnatal life. Hair regression is an apoptosis-driven process strictly controlled by micro- and macro-environmental signals. However, how these signals are controlled remains largely unknown. Hoxc13, a member of the Hox gene family, is reported to play an important role in hair follicle differentiation. In the present study, we observed that Hoxc13 was highly expressed in the outer root sheath, matrix, medulla and inner root sheath of hair follicles in a hair cycle-dependent manner. We therefore investigated th... περισσότερα »
Augmented Indian hedgehog signaling in cranial neural crest cells leads to craniofacial abnormalities and dysplastic temporomandibular joint in mice
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Abstract Extensive studies have pinpointed the crucial role of Indian hedgehog (Ihh) signaling in the development of the appendicular skeleton and the essential function of Ihh in the formation of the temporomandibular joint (TMJ). In this study, we have investigated the effect of augmented Ihh signaling in TMJ development. We took a transgenic gain-of-function approach by overexpressing *Ihh* in the cranial neural crest (CNC) cells using a conditional *Ihh* transgenic allele and the *Wnt1-Cre* allele. We found that *Wnt1-Cre*-mediated tissue-specific overexpression of *Ihh* in the... περισσότερα »
Can Sonography Distinguish a Supraorbital Notch From a Foramen?
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Can Sonography Distinguish a Supraorbital Notch From a Foramen?: Diagnostic tools for evaluating the supraorbital rim in preparation for nerve decompression surgery in patients with chronic headaches are currently limited. We evaluated the use of sonography to diagnose the presence of a supraorbital notch or foramen in 11 cadaver orbits. Sonographic findings were assessed by dissecting cadaver orbits to determine whether a notch or foramen was present. Sonography correctly diagnosed the presence of a supraorbital notch in 7 of 7 cases and correctly diagnosed a supraorbital foramen ...περισσότερα »
VEGFA splicing: divergent isoforms regulate spermatogonial stem cell maintenance
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Abstract Despite being well-known for regulating angiogenesis in both normal and tumorigenic environments, vascular endothelial growth factor A (VEGFA) has been recently implicated in male fertility, namely in the maintenance of spermatogonial stem cells (SSC). The *VEGFA* gene can be spliced into multiple distinct isoforms that are either angiogenic or antiangiogenic in nature. Although studies have demonstrated the alternative splicing of VEGFA, including the divergent roles of the two isoform family types, many investigations do not differentiate between them. Data concerning VE...περισσότερα »
RANKL regulates differentiation of microfold cells in mouse nasopharynx-associated lymphoid tissue (NALT)
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Abstract Murine nasopharynx-associated lymphoid tissue (NALT), located at the base of the nasal cavity, serves as a major site for the induction of mucosal immune responses against airway antigens. The follicle-associated epithelium (FAE) covering the luminal surface of NALT is characterized by the presence of microfold cells (M cells), which take up and transport luminal antigens to lymphocytes. Glycoprotein 2 (GP2) has recently been identified as a reliable marker for M cells in Peyer's patches of the intestine. However, the expression of GP2 and other functional molecules in th... περισσότερα »
Involvement of phosphoinositide 3-kinase class IA (PI3K 110α) and NADPH oxidase 1 (NOX1) in regulation of vascular differentiation induced by vascular endothelial growth factor (VEGF) in mouse embryonic stem cells
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Abstract The impact of reactive oxygen species and phosphoinositide 3-kinase (PI3K) in differentiating embryonic stem (ES) cells is largely unknown. Here, we show that the silencing of the PI3K catalytic subunit *p110α* and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 (*NOX1*) by short hairpin RNA or pharmacological inhibition of NOX and ras-related C3 botulinum toxin substrate 1 (Rac1) abolishes superoxide production by vascular endothelial growth factor (VEGF) in mouse ES cells and in ES-cell-derived fetal liver kinase-1+ (Flk-1+) vascular progenitor cells, wher... περισσότερα »
Hoxc13 is a crucial regulator of murine hair cycle
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Abstract Hair follicles undergo cyclical growth and regression during postnatal life. Hair regression is an apoptosis-driven process strictly controlled by micro- and macro-environmental signals. However, how these signals are controlled remains largely unknown. Hoxc13, a member of the Hox gene family, is reported to play an important role in hair follicle differentiation. In the present study, we observed that Hoxc13 was highly expressed in the outer root sheath, matrix, medulla and inner root sheath of hair follicles in a hair cycle-dependent manner. We therefore investigated th... περισσότερα »
Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
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Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
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The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
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Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
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Modifiers of solid RNP granules control normal RNP dynamics and mRNA activity in early development
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Ribonucleoproteins (RNPs) often coassemble into supramolecular bodies with regulated dynamics. The factors controlling RNP bodies and connections to RNA regulation are unclear. During *Caenorhabditis elegans* oogenesis, cytoplasmic RNPs can transition among diffuse, liquid, and solid states linked to mRNA regulation. Loss of CGH-1/Ddx6 RNA helicase generates solid granules that are sensitive to mRNA regulators. Here, we identified 66 modifiers of RNP solids induced by *cgh-1* mutation. A majority of genes promote or suppress normal RNP body assembly, dynamics, or metabolism. Surpr...περισσότερα »
Protrusive waves guide 3D cell migration along nanofibers
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
In vivo, cells migrate on complex three-dimensional (3D) fibrous matrices, which has made investigation of the key molecular and physical mechanisms that drive cell migration difficult. Using reductionist approaches based on 3D electrospun fibers, we report for various cell types that single-cell migration along fibronectin-coated nanofibers is associated with lateral actin-based waves. These cyclical waves have a fin-like shape and propagate up to several hundred micrometers from the cell body, extending the leading edge and promoting highly persistent directional movement. Cells ... περισσότερα »
GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Pseudostratified airway epithelium of the lung is composed of polarized ciliated and secretory cells maintained by basal stem/progenitor cells. An important question is how lineage choice and differentiation are coordinated with apical–basal polarity and epithelial morphogenesis. Our previous studies indicated a key integrative role for the transcription factor Grainyhead-like 2 (Grhl2). In this study, we present further evidence for this model using conditional gene deletion during the regeneration of airway epithelium and clonal organoid culture. We also use CRISPR/Cas9 genome e... περισσότερα »
Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Notch family members are transmembrane receptors that mediate essential developmental programs. Upon ligand binding, a proteolytic event releases the intracellular domain of Notch, which translocates to the nucleus to regulate gene transcription. In addition, Notch trafficking across the endolysosomal system is critical in its regulation. In this study we report that Notch recycling to the cell surface is dependent on the COMMD–CCDC22–CCDC93 (CCC) complex, a recently identified regulator of endosomal trafficking. Disruption in this system leads to intracellular accumulation of Not... περισσότερα »
Non-invasive prenatal screening for trisomy 21: Consumers' perspectives
Alexandros G. SfakianakisστοEvolution of a geneΠριν από 30 δευτερόλεπτα
Non-invasive prenatal screening (NIPS) has the potential to dramatically increase the prenatal detection rate of Down syndrome because of improvements in safety and accuracy over existing tests. There is concern that NIPS could lead to more negative attitudes towards Down syndrome and less support for individuals with Down syndrome. To assess the impact of NIPS on support for prenatal testing, decision-making about testing, and beliefs or attitudes about Down syndrome, we performed an Internet-based experiment using adults (N = 1,789) recruited through Amazon Mechanical Turk. Par... περισσότερα »
Body proportions in children with Kabuki syndrome
Alexandros G. SfakianakisστοEvolution of a geneΠριν από 30 δευτερόλεπτα
Facial characteristics, short stature, and skeletal anomalies have been described for the clinical diagnosis of Kabuki Syndrome (KS) in children. However, no studies have investigated body proportions in KS. Knowledge of body proportions in KS may contribute to better insight into the growth pattern and characterization of this genetic disorder. Therefore we compared body proportions of children with KS to normally proportioned controls to investigate if atypical body proportions are part of this genetic disorder. This study was designed and conducted within the setting of the Ma... περισσότερα »
Cerebral venous thrombosis (CVT)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Postdural Puncture Superior Sagittal Sinus Thrombosis in a Juvenile Case of Clinically Isolated Syndrome: Background. The causes of cerebral venous thrombosis (CVT) are manifold as is its clinical presentation. Case. We report the case of a CVT following lumbar puncture and intravenous glucocorticosteroid therapy in a female adolescent with a clinically isolated syndrome and risk factors for thrombosis. Conclusion. In adolescent patients with acute inflammatory disease undergoing lumbar puncture followed by intravenous high-dose glucocorticosteroid therapy, one should be aware of th... περισσότερα »
Congenital Insensitivity to Pain and Anhidrosis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Update Review and Clinical Presentation in Congenital Insensitivity to Pain and Anhidrosis: Introduction. Congenital insensitivity to pain and anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV is an extremely rare syndrome. Three clinical findings define the syndrome: insensitivity to pain, impossibility to sweat, and mental retardation. This pathology is caused by a genetic mutation in the NTRK1 gene, which encodes a tyrosine receptor (TrkA) for nerve growth factor (NGF). Methods. The consultation of a child female in our center with CIPA and a tibia fracture ... περισσότερα »
Klippel-Trenaunay Syndrome with Extensive Lymphangiomas
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Klippel-Trenaunay Syndrome with Extensive Lymphangiomas: Klippel-Trenaunay syndrome (KTS) is a rare disorder characterized by the triad of vascular malformations, venous varicosities, and bone and soft-tissue hypertrophy. We present a case of Klippel-Trenaunay syndrome with limb hypertrophy, port-wine stains, lymphangiomas, and venous varicosities in the limbs.
The Role of PCR in the Diagnosis of Candida Vulvovaginitis—a New Gold Standard?
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
The Role of PCR in the Diagnosis of Candida Vulvovaginitis—a New Gold Standard?: AbstractPCR is recognized as a reliable technique for detection of all types of microorganisms. Being highly objective and reproducible also sensitive and specific, PCR is now widely used for sexually transmitted infection (STI) diagnosis. Potential, however, exists for detecting non-pathogens, and not identifying a pathogenic state decreases specificity or clinical significance. PCR *Candida* tests of vaginal specimens are now widely available and frequently used offering a modest to moderate increase... περισσότερα »
Touchless Technologies for Decontamination in the Hospital
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Touchless Technologies for Decontamination in the Hospital: a Review of Hydrogen Peroxide and UV Devices: AbstractReduction of microbial contamination of the hospital environment is a challenge, yet has potential impacts on infection prevention efforts. Fumigation and UV light devices for environmental cleaning have expanded into the health care setting with the goal of decontamination of difficult to clean or overlooked surfaces. In an era of increased scrutiny of hospital-acquired infections, increasingly, health care centers are adopting these “touchless” cleaning techniques as ...περισσότερα »
The Value of Macrolide-Based Regimens for Community-Acquired Pneumonia
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
The Value of Macrolide-Based Regimens for Community-Acquired Pneumonia: AbstractMacrolide antimicrobials are commonly prescribed, specifically for the treatment of respiratory tract infections. Although still effective, the development of widespread macrolide resistance has limited their use. Aside from their antimicrobial effects, macrolides are also known to possess immune-modulatory properties which may confer a survival benefit in both acute and chronic inflammatory states. This review discusses the efficacy, potential mechanisms, and adverse effects of macrolide therapy specif... περισσότερα »
Magnetic Resonance Imaging of the Temporomandibular Joint at 7.0 T Using High-Permittivity Dielectric Pads: A Feasibility Study
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
Magnetic Resonance Imaging of the Temporomandibular Joint at 7.0 T Using High-Permittivity Dielectric Pads: A Feasibility Study: [image: image]Objectives: The aims of this study were to show feasibility and to quantitatively and qualitatively evaluate the use of high-permittivity dielectric pads for imaging the temporomandibular joint (TMJ) at 7.0 T. Materials and Methods: This study is an institutional review board–approved study with written informed consent. Ten asymptomatic volunteers (20 TMJs) were magnetic resonance imaged using a 32-channel head coil at 7.0 T (Achieva; Philips...περισσότερα »
Sarcoidosis and lymphoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
Sarcoidosis and lymphoma: a comparative study: *Aim:* To assess the clinical features and outcome of lymphoma when associated with sarcoidosis and to determine whether this association gives lymphoma a better prognosis. *Design*: Multicentre retrospective cohort study. *Methods*: Retrospective chart review. *Results:* Twenty-one patients were included (9 males, 12 females). Median age at sarcoidosis diagnosis was 48 years (range: 24–68 years). In 14 cases, lymphoma occurred within a previously known sarcoidosis. Five patients received a concomitant diagnosis of sarcoidosis and lym...περισσότερα »
Emerging Treatments for Neuropathic Pain
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Emerging Treatments for Neuropathic Pain: AbstractNeuropathic pain is a series of well-known conditions caused by diseases or lesions to the somatosensory system. Due to the better understanding of the pathophysiology of neuropathic pain, previously unexplored therapies have been used with encouraging results. As such, Acetyl-L-carnitine (ALC), Alpha-lipoic-acid (ALA), cannabinoids, Clonidine, EMA401, Botulinum Toxin type A, and new voltage-gated sodium channel blockers, can be cited. Furthermore, new modalities in neuromodulation such as high-frequency spinal cord stimulation, bur... περισσότερα »
Unexpected radiation laryngeal necrosis after carbon ion therapy using conventional dose fractionation for laryngeal cancer
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Unexpected radiation laryngeal necrosis after carbon ion therapy using conventional dose fractionation for laryngeal cancer: Carbon ion therapy is a type of radiotherapy that can deliver high-dose radiation to a tumor while minimizing the dose delivered to organs at risk. Moreover, carbon ions are classified as high linear energy transfer radiation and are expected to be effective for even photon-resistant tumors. A 73-year-old man with glottic squamous cell carcinoma, T3N0M0, refused laryngectomy and received carbon ion therapy of 70 Gy (relative biological effectiveness) in 35 fr... περισσότερα »
Neoadjuvant chemoradiotherapy for locoregional esophageal cancer
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Systematic review and network meta-analysis: neoadjuvant chemoradiotherapy for locoregional esophageal cancer: Objective Neoadjuvant chemoradiotherapy improves survival in patients with locoregional esophageal cancer. This study compares the efficacy of two common regimens, paclitaxel plus platinum and platinum plus 5-fluorouracil, based on overall survival. Methods We performed a systematic review and network meta-analysis of randomized trials comparing paclitaxel plus platinum-neoadjuvant chemoradiotherapy or and platinum plus 5-fluorouracil-neoadjuvant chemoradiotherapy with sur...περισσότερα »
Cognitive Dysphagia and Effectively Managing The Five Systems
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Cognitive Dysphagia and Effectively Managing The Five Systems: In order for a person to swallow safely and effectively, five bodily systems must work in coordination. Dysphagia occurs when there is a breakdown in one or more of these systems: neurological (NeuroDys), cognitive (CogDys), muscular (MuscDys), respiratory (RespDys), and gastrointestinal (GIDys). The present perspective discusses cognitive decline preceding or concurrently degrading mechanisms of the swallow. We put forth current evidence supporting the premise that cognitive decline can cause dysphagia, and that dysphagi... περισσότερα »
An International Perspective on Speech-Language Pathology Assistants
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
An International Perspective on Speech-Language Pathology Assistants: In 2011, the World Health Organization (WHO) and the World Bank highlighted several pressing concerns in the area of service provision to individuals with disabilities, including a global shortage of rehabilitation personnel. The use of mid-level workers was recommended as one strategy for improving human resource capacity in this area. In the United States, speech-language pathology assistants (SLPAs) are one type of mid-level worker that has received recent attention. The American Speech-Language and Hearing Ass... περισσότερα »
Ciliated HPV-related Carcinoma: A Well-differentiated Form of Head and Neck Carcinoma That Can Be Mistaken for a Benign Cyst
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα
Ciliated HPV-related Carcinoma: A Well-differentiated Form of Head and Neck Carcinoma That Can Be Mistaken for a Benign Cyst: [image: image] Although human papillomavirus (HPV)-related oropharyngeal carcinomas (HPV-OPCs) are generally regarded as “poorly differentiated,” they actually maintain a close resemblance to the lymphoepithelium of the tonsillar crypts from which they arise: they are basaloid, exhibit minimal keratinization, and are often permeated by lymphocytes. In rare cases, the presence of cilia in a primary HPV-OPC and their persistence in lymph node metastasis can co... περισσότερα »
Intralymphatic Spread Is a Common Finding in Cutaneous CD30+ Lymphoproliferative Disorders
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα
Intralymphatic Spread Is a Common Finding in Cutaneous CD30+ Lymphoproliferative Disorders: [image: image]An intralymphatic variant of the cutaneous CD30+ lymphoproliferative disorders (cutaneous anaplastic large cell lymphoma [ALCL] and lymphomatoid papulosis [LyP]) has been described recently. We retrieved 60 cases of ALCL of the skin (primary cutaneous: 37; cases with concomitant involvement of 1 regional lymph node: 4; skin involvement from systemic disease: 4; cases with staging results unknown: 15) and 16 cases of LyP, to evaluate the presence of lymphatic vessel involvement b... περισσότερα »
Lymphocytic Esophagitis With CD4 T-cell–predominant Intraepithelial Lymphocytes and Primary Esophageal Motility Abnormalities
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα
Lymphocytic Esophagitis With CD4 T-cell–predominant Intraepithelial Lymphocytes and Primary Esophageal Motility Abnormalities: A Potential Novel Clinicopathologic Entity: [image: image] Lymphocytic esophagitis (LE) is an uncommon poorly defined histologic pattern. Its significance is largely unknown. The goal of our study was to characterize LE clinically, histologically, and immunophenotypically. Biopsies of 45 patients with LE and no intraepithelial granulocytes were selected throughout a 36-month period during routine diagnostic work. After reevaluation, complete absence of intr... περισσότερα »
Angiosarcoma Arising in Chronic Expanding Hematoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα
Angiosarcoma Arising in Chronic Expanding Hematoma: Five Cases of an Underrecognized Association: Little is known about the etiology or pathogenesis of angiosarcoma (AS). We describe a series of 5 cases of AS arising in chronic expanding hematomas. Inclusion criteria were the presence of a hematoma of at least 1-year duration and a thick fibrous wall surrounding the hematoma. Patients were 4 men and 1 woman; ages ranged from 43 to 71 years. Locations were the thigh (3), chest wall (1), and pelvic soft tissue involving the ischial bone (1). Hematoma duration ranged from 2 to 25 years...περισσότερα »
Untreated Primary Diffuse Large B-cell Lymphoma of the Tonsil
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα
Long-term Tumor-free Survival With Untreated Primary Diffuse Large B-cell Lymphoma of the Tonsil: A Report of 9 Cases: [image: image]In some cases, long-term tumor-free survival might be possible for untreated primary diffuse large B-cell lymphoma (DLBCL) of the tonsil. Here, we report of 9 untreated patients who had primary tonsil DLBCL with long-term tumor-free survival. All these patients were children or young adults (4 male and 5 female individuals; ages: 6 to 38 y, median age: 25 y) with clinically evident swollen tonsils or papillary neoplasms. Tonsillectomy and biopsies indi...περισσότερα »
Warthin-like Mucoepidermoid Carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα
Warthin-like Mucoepidermoid Carcinoma: A Combined Study of Fluorescence In Situ Hybridization and Whole-slide Imaging: There has been some debate as to whether a subset of metaplastic Warthin tumors (mWTs) harbor the mucoepidermoid carcinoma (MEC)-associated CRTC1-MAML2 fusion. We analyzed 15 tumors originally diagnosed as mWT (mWT-like tumors), 2 of which had concurrent MECs. We looked for the CRTC1/3-MAML2 fusion transcripts and performed immunohistochemistry for p63 and fluorescence in situ hybridization (FISH) for the MAML2 split. To localize MAML2 split–positive cells at the ce... περισσότερα »
Extensively Myxoid and Hyalinized Sinonasal Capillary Hemangiomas
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα
Extensively Myxoid and Hyalinized Sinonasal Capillary Hemangiomas: A Clinicopathologic Study of 16 Cases of a Distinctive and Potentially Confusing Hemangioma Variant: [image: image]Capillary hemangiomas, the most common vascular tumors of the sinonasal region, are benign endothelial neoplasms, typically growing in an easily recognized lobular pattern. Some sinonasal capillary hemangiomas may show atypical features, such as high cellularity or mitotic activity, and represent more challenging diagnoses. Over the past several years we have seen in consultation a number of examples of ...περισσότερα »
Emergency Computed Tomography: What is Missed at First Reading?.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα
Emergency Computed Tomography: What is Missed at First Reading?.: Objectives: The aim of this study was to evaluate the accuracy of preliminary computed tomography (CT) interpretations made by radiology residents in the emergency department. Methods: For 4 periods of 20 consecutive days, attending radiologists prospectively recorded any disparities between their own CT interpretations (reference standard) and the preliminary interpretations of emergency radiology residents. Misinterpretations were defined as major when related to a potentially life-threatening pathology if not immedi...περισσότερα »
Whole-Body Diffusion Tensor Imaging: A Feasibility Study.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
Whole-Body Diffusion Tensor Imaging: A Feasibility Study.: Objective: The aim of this study was to demonstrate the feasibility of whole-body diffusion tensor imaging (DTI) as a promising tool for research applications, for instance, for investigation of systemic muscle diseases. Materials and Methods: Twelve healthy volunteers (mean age, 26.6 years; range, 20-39 years) underwent whole-body magnetic resonance imaging at 3 T using an echo planar imaging sequence (b value, 400 s/mm2) with 6 different spatial encoding directions. Coronal maps of DTI parameters including mean diffusivity,...περισσότερα »
An Image-Based Reduction of Metal Artifacts in Computed Tomography.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
An Image-Based Reduction of Metal Artifacts in Computed Tomography.: Objective: Various strategies have been developed in the past to reduce the excessive effects of metal artifacts in computed tomography images. From straightforward sinogram inpainting-based methods to computationally expensive iterative methods, all have been successful in improving the image quality up to a certain degree. We propose a novel image-based metal artifact subtraction method that achieves a superior image quality and at the same time provides a quantitatively more accurate image. Methods: Our proposed ...περισσότερα »
Interobserver Variation in Cerebellar Tonsillar Tip Localization: Comparison of 3 Different Osseous Landmarks on Magnetic Resonance Imaging.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
Interobserver Variation in Cerebellar Tonsillar Tip Localization: Comparison of 3 Different Osseous Landmarks on Magnetic Resonance Imaging.: Purpose: The aim was to evaluate the interobserver agreement in the assessment of cerebellar tonsil position on sagittal magnetic resonance imaging using 3 different osseous landmarks. Materials and Methods: This retrospective study consisted of brain magnetic resonance imagings performed at our institution in patients with and without Chiari I malformation between January 2010 and 2012. Sagittal T1-weighted images were reviewed by 2 senior boa...περισσότερα »
Treatment outcome of the transfacial Ti-Epiplating-System for total nasal defects.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
Treatment outcome of the transfacial Ti-Epiplating-System for total nasal defects.: Background: Malignant tumors are the most frequent reason for acquired defects of the nose. Bone-anchored craniofacial prostheses represent a secure, uncomplicated and cosmetically acceptable rehabilitative alternative to surgical reconstruction.The aim of our study was to determine a potential benefit of the Ti-Epiplating-System (Fa. Medicon, Tuttlingen, Germany)as a grouped implant system in the anatomical difficult nasal region with limited bone supply. Patients and Methods: Patients with complete ... περισσότερα »
Platelet-rich fibrin: the benefits
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Current published data presents confusing results about the effects of platelet-rich fibrin on bone, and there is a need for studies that throw light on its effect. Our main objective therefore was to evaluate (by fractal analysis) osseous regeneration in extraction sockets with and without platelet-rich fibrin in a study with a substantial sample and a reliable technique to calibrate its effects on bone cells. We also assessed the soft tissue response. Thirty-four patients had their bilaterally impacted third molars (68 surgical sites) extracted in this split-mouth study, followi... περισσότερα »
A new way to target p53-defective colorectal cancer
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 1 ώρα
Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/1RK4mEL via IFTTT
Photodynamic therapy for basal cell carcinoma
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 1 ώρα
Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/1RK4pjO via IFTTT
Corrigendum
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 1 ώρα
Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/1kmd1CT via IFTTT
Richard Bruynoghe (1881–1957)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
At the Centennial of the Bacteriophage: Reviving the Overlooked Contribution of a Forgotten Pioneer, Richard Bruynoghe (1881–1957): AbstractThe year 2015 marks the 100th anniversary of a publication by William Twort, in which he first described lysis of bacterial cultures by a filterable, self-replicating agent. In 1917, Félix d’Herelle, coined the name “bacteriophage” for the proposed agent. Two Belgian teams of microbiologists were among the few to critically examine the nature of the bacteriophage at that time. Although their experimental results agreed, their interpretations di... περισσότερα »
Imaging characteristics of pleural tumours
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Imaging characteristics of pleural tumours: AbstractMalignant mesothelioma is doubtless the more known pleural tumour. However, according to the morphology code of the International Classification of Diseases for Oncology (ICD-O), there are several histological types of pleural neoplasms, divided into mesothelial, mesenchymal and lymphoproliferative tumours, that may be misdiagnosed. In this paper we summarise and illustrate the incidence aspects and the clinical, pathological and radiological features of these neoplasms. *Teaching Points* • *According to the ICD-O, there are 1... περισσότερα »
Orbital tumours and tumour-like lesions: exploring the armamentarium of multiparametric imaging
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Orbital tumours and tumour-like lesions: exploring the armamentarium of multiparametric imaging: AbstractAlthough the orbit is a small anatomical space, the wide range of structures present within it are often the site of origin of various tumours and tumour-like conditions, both in adults and children. Cross-sectional imaging is mandatory for the detection, characterization, and mapping of these lesions. This review focuses on multiparametric imaging of orbital tumours. Each tumour is reviewed in relation to its clinical presentation, compartmental location, imaging characteristic... περισσότερα »
Panitumumab-induced Acneiform Rash : Prophylactic Effect of Oral Minocycline in Combination with Topical Steroid and Skin Care
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Prophylactic Effect of Oral Minocycline in Combination with Topical Steroid and Skin Care Against Panitumumab-induced Acneiform Rash in Metastatic Colorectal Cancer Patients: Background: Although the anti-EGFR monoclonal antibody panitumumab is effective in treating colorectal cancer, the occurrence of severe skin disorders often discontinues therapy. Herein, we investigated by a retrospective chart review the effect of prophylactic oral minocycline in combination with skin treatment using moisturizer on the incidence of skin disorders and tumor response in metastatic colorectal ca...περισσότερα »
Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors: Introduction: Thymic carcinomas and thymic neuroendocrine tumors are rare diseases often treated with surgical resection. Currently, there are no guidelines regarding nodal dissection at the time of tumor resection. Moreover, the prognostic significance of nodal metastases is unclear. The goal of this study was to define the incidence and prognostic relevance of nodal metastases in patients with thymic carcinoma and thymic neuroendocrine tumors. Methods: The Surveillance, Epidemi...περισσότερα »
Patch Testing for Metal Allergy With Manufacturer-Supplied Materials Before Nuss Bar Insertion
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Patch Testing for Metal Allergy With Manufacturer-Supplied Materials Before Nuss Bar Insertion: [image: image]Introduction: The increasing use of metal implantable devices has raised awareness of nickel allergy. Preoperative patch testing for patients with pectus excavatum (PE) with a known metal allergy or history of atopy is an accepted practice before the Nuss procedure. The Nuss bar manufacturer offers a metal disc for preoperative testing for metal sensitivities. However, the efficacy of this disc is not well understood. Objective: The purpose of this study was to determine the ... περισσότερα »
Erythroderma due to Unwitting Exposure to an Unobvious Allergen Source
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Erythroderma due to Unwitting Exposure to an Unobvious Allergen Source:
Cutaneous Delayed-Type Hypersensitivity to Surfactants
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Cutaneous Delayed-Type Hypersensitivity to Surfactants: [image: image] Background: Repeated and prolonged use of surfactants can cause irritant as well as allergic contact dermatitis. Objective: This study reports the frequency of positive patch test results to surfactants tested on the North American Contact Dermatitis Group screening series including cocamidopropyl betaine (CAPB), amidoamine (AA), dimethylaminopropylamine (DMAPA), oleamidopropyl dimethylamine (OPD), and cocamide diethanolamide (CDEA), and correlations of positive reactions between CAPB and the other surfactants. M... περισσότερα »
Contact Allergy to Surfactants in a Hypoallergenic Liquid Cleanser
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Contact Allergy to Surfactants in a Hypoallergenic Liquid Cleanser: [image: image] Surfactants are a relatively rare cause of allergic contact dermatitis (ACD) and testing patients to personal care products containing these ingredients has historically been difficult given their irritant properties. Using the semiopen technique, we were able to identify ACD to a hypoallergenic liquid cleanser in 2 patients who presented to our patch test clinic only months apart. Additional patch testing to individual ingredients led to subsequent identification of 3 novel surfactant allergens (sod... περισσότερα »
Epidermal Expression of Filaggrin/Profilaggrin Is Decreased in Atopic Dermatitis: Reverse Association With Mast Cell Tryptase and IL-6 but Not With Clinical Severity
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Epidermal Expression of Filaggrin/Profilaggrin Is Decreased in Atopic Dermatitis: Reverse Association With Mast Cell Tryptase and IL-6 but Not With Clinical Severity: [image: image]Background: A decrease in filaggrin expression contributes to the pathogenesis of atopic dermatitis (AD) and can be modified by inflammatory factors. Objectives: The aim of this study was to determine the correlation of (pro)filaggrin (filaggrin and profilaggrin) expression with clinical severity in AD and with mast cell (MC) tryptase, chymase, and IL-6. Methods: Punch biopsies were collected from 17 patien... περισσότερα »
“Parabenoia” Debunked, or “Who’s Afraid of Parabens?”
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
“Parabenoia” Debunked, or “Who’s Afraid of Parabens?”: Parabens have been used as preservatives in foods, injectables, and topical preparations for nearly 10 decades. Present in nature, rapidly metabolized by skin and liver enzymes, they have an excellent safety record. However, in the past 15 years, they have been under scrutiny for their alleged estrogenic and antiandrogenic effects, as well as their putative role in promoting cancerogenesis through endocrine disruption. Scientific articles supporting these assertions have led the European Community to ban or restrict the use of s... περισσότερα »
Occupational Airborne Contact Dermatitis From Proton Pump Inhibitors
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Occupational Airborne Contact Dermatitis From Proton Pump Inhibitors: [image: image] Few published reports have described occupational contact dermatitis from proton pump inhibitor (PPI) exposure in the literature. We present an additional case of a 58-year-old male pharmaceutical worker with an occupational airborne allergic contact dermatitis to PPIs confirmed by patch testing. This is a novel report of workplace exposure to dexlansoprazole and esomeprazole PPIs with resultant clinical contact allergy and relevant positive patch test results to these 2 agents. A literature review...περισσότερα »
Occupational Contact Dermatitis: Workers’ Compensation Patch Test Results of Portland, Oregon, 2005–2014
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Occupational Contact Dermatitis: Workers’ Compensation Patch Test Results of Portland, Oregon, 2005–2014: Background: Workers are exposed to potential irritants and allergens with constant introduction of new industrial chemicals in the workplace. Objective: Characterize the final diagnoses, demographics, occupations, exposures, clinical presentations, patch test results, dermatologic histories, and risk factors of workers evaluated for suspected work-related allergic contact dermatitis (ACD). Methods: A retrospective chart review of 310 workers’ compensation independent medical exa... περισσότερα »
Conjugative transfer of a derivative of the IncP-1{alpha} plasmid RP4 and establishment of transconjugants in the indigenous bacterial community of poplar plants
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
The persistence of traits introduced into the indigenous bacterial community of poplar plants was investigated using bioluminescence mediated by the *luc* gene. Three endophytic bacterial strains provided with the IncP-1α plasmid RP4-Tn-*luc* were used to inoculate poplar cuttings at different phenological stages. Screening of isolates by bioluminescence and real-time PCR detection of the *luc* gene revealed stable persistence for at least 10 weeks. Although the inoculated strains became established with a high population density after inoculation at leaf development (April) and s... περισσότερα »
Differential expression of putative drug resistance genes in Mycobacterium tuberculosis clinical isolates
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Understanding drug resistance in *Mycobacterium tuberculosis* requires an integrated analysis of strain lineages, mutations and gene expression. Previously, we reported the differential expression of *esxG*, *esxH*, *infA*, *groES*, *rpmI*, *rpsA* and *lipF* genes in a sensitive *M. tuberculosis* strain and in a multidrug-resistant clinical isolate. Here, we have evaluated the expression of these genes in 24 clinical isolates that belong to different lineages and have different drug resistance profiles. *In vitro*, growth kinetics analysis showed no difference in the growth of the... περισσότερα »
Asymptomatic people can transmit Dengue viruses to Mosquitos
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
75% of the ~390 million people infected with dengue viruses present with no symptoms (asymptomatic). It is generally assumed that these asymptomatic infections cannot be transmitted to mosquitos. Not only does this study show that people with asymptomatic infections transmitted the virus to mo... from Infection via ola Kala on Inoreader http://ift.tt/1HrPoTv via IFTTT
OtoRhinoLaryngology New Articles,November 9th,2015,a
Alexi ViadisστοHead and Neck Medicine by Alexandros G.SfakianakisΠριν από 15 ώρες
Canalplasty for Exostoses With Maximal Skin Preservation With Temporoparietal Fascia Grafting and Use of Bone Wax for Skin Flap Protection: A Retrospective Case Series *Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα* *Canalplasty for Exostoses With Maximal Skin Preservation With Temporoparietal Fascia Grafting and Use of Bone Wax for Skin Flap Protection: A Retrospective Case Series: Background: External auditory canal exostoses are benign, bony overgrowths that arise in patients who experience chronic cold water exposure. While co...περισσότερα »
Radiation in Human Vocal Fold Fibroblasts
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 ώρες
Early Cellular Response to by Erickson-DiRenzo, E., Enos, G., Thibeault, S. L. via Annals of Otology, Rhinology & Laryngology RSS feed -- OnlineFirst Articles Objectives:Radiation therapy is a common treatment strategy for laryngeal carcinoma. However, radiation is not without adverse side effects, especially toward healthy vocal fold tissue, which can lead to long-term impairments in vocal function. The objective of this preliminary study was to investigate early responses of healthy human vocal fold fibroblasts (VFF) to radiation. Methods:VFF were exposed to a single or fractionate... περισσότερα »
Outcomes of Laryngeal Reinnervation for Unilateral Vocal Fold Paralysis in Children: Associations With Age and Time Since Injury
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 ώρες
Outcomes of Laryngeal Reinnervation for Unilateral Vocal Fold Paralysis in Children: Associations With Age and Time Since Injury: Objective: Outcomes of laryngeal reinnervation with ansa-cervicalis for unilateral vocal fold paralysis (UVFP) may be influenced by age of the patient and time interval between laryngeal nerve injury and reinnervation, suggesting less favorable outcomes in older patients and greater than 2-year time interval after injury. This study examines these issues in the pediatric population. Method: Review of prospectively collected data set of 35 children and ad... περισσότερα »
Clinical Evaluation of Sinonasal Lesions in Patients With Immunoglobulin G4-Related Disease
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 ώρες
Clinical Evaluation of Sinonasal Lesions in Patients With Immunoglobulin G4-Related Disease: Objectives: Immunoglobulin G4-related disease (IgG4-RD) is a systemic disease entity characterized by elevated serum IgG4 and extensive IgG4-positive plasma cell infiltration of various organs. Patients with IgG4-RD show nasal manifestations with chronic rhinosinusitis. The objective of this study was to evaluate the clinical characteristics of sinonasal lesions in patients with IgG4-RD. Methods: We evaluated radiological findings of sinonasal lesions in 79 patients with IgG4-RD who were d...περισσότερα »
The Impact of Pepsin on Human Nasal Epithelial Cells In Vitro: A Potential Mechanism for Extraesophageal Reflux Induced Chronic Rhinosinusitis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 ώρες
The Impact of Pepsin on Human Nasal Epithelial Cells In Vitro: A Potential Mechanism for Extraesophageal Reflux Induced Chronic Rhinosinusitis: Objectives: To describe potential mechanisms by which pepsin induces inflammation in refractive chronic rhinosinusitis (CRS). Our hypothesis was that pepsin induces mitochondrial damage and cytokine expression in human nasal epithelial cells (HNEpC) in vitro. Methods: Western blot was used to detect pepsin in sinus lavages from patients with CRS and controls. The HNEpC cells were treated with pepsin (pH 7; 0.1 mg/mL) for 1 or 16 hours and ...περισσότερα »
Decisional Conflict in Parents Considering Bone-Anchored Hearing Devices in Children With Unilateral Aural Atresia
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 ώρες
Decisional Conflict in Parents Considering Bone-Anchored Hearing Devices in Children With Unilateral Aural Atresia: Objective: The benefits of bone-anchored hearing devices (BAHD) in children with unilateral aural atresia are controversial. We sought to determine whether there is parental decisional conflict surrounding elective placement of BAHD for this indication. Methods: Caregivers of pediatric patients with unilateral aural atresia and normal contralateral ear undergoing percutaneous BAHD consultation were enrolled. All consultations were carried out by one pediatric otolaryn... περισσότερα »
Medial and Superior Orbital Decompression: Improving Access for Endonasal Endoscopic Frontal Sinus Surgery
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 ώρες
Medial and Superior Orbital Decompression: Improving Access for Endonasal Endoscopic Frontal Sinus Surgery: Objective: Visualization by Draf I-III endoscopic access to the frontal sinus via drainage pathways is sometimes inadequate. We compare lateral frontal sinus exposures by Draf approaches versus our modification of removing the medial-superior wall of the orbit while preserving the periorbita. Methods: Twenty cadaveric heads dissected using Draf IIB, III, and modified Draf III with medial and superior orbital decompression (MSOD) underwent thin-cut computed tomography (CT) sca... περισσότερα »
Acoustic Hearing After Murine Cochlear Implantation: Effects of Trauma and Implant Type
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 ώρες
Acoustic Hearing After Murine Cochlear Implantation: Effects of Trauma and Implant Type: Objectives: To model the contribution of implant material and insertion trauma on loss of acoustic hearing after cochlear implantation in an appropriate animal model. Methods: Sixty-five C57Bl/6J mice underwent unilateral implantation with implant grade materials: 2 implant grade silicones and a third uncoated platinum wire. A sham surgery group was included as a control. Serial auditory brainstem response (ABR) thresholds and distortion product otoacoustic emissions (DPOAEs) were used to disc...περισσότερα »
Airway and Respiration Parameters Improve Following Vocal Fold Medialization: A Prospective Study
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 ώρες
Airway and Respiration Parameters Improve Following Vocal Fold Medialization: A Prospective Study: Objectives/Hypothesis: Laryngeal medialization procedures such as injection laryngoplasty (IL) and thyroplasty type 1 (TT1) are standard techniques for the treatment of glottic insufficiency related to unilateral vocal fold paralysis (UVFP). These procedures reliably improve the voice and may also improve swallowing function. Despite the association of laryngeal paralysis with airway regulation, there is little published on the effect of UVFP and its surgical treatment on respiration. ...περισσότερα »
The Otalgia Point: A Novel Clinical Gesture in Otolaryngology
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 ώρες
The Otalgia Point: A Novel Clinical Gesture in Otolaryngology: Introduction: In cases of otalgia without any accompanying findings, some patients locate their otalgia below the attachment of the lobule, at the apex of the jugulodigastric region. Purpose: To present a series of these patients for whom nasal steroids or myringotomy usually ameliorated their pain. Materials and Methods: Thirty-two patients with normal physical examinations, tympanograms, and age-appropriate audiograms spontaneously indicated otalgia at "the otalgia point." Inspection of the oropharynx and nasal airwa...περισσότερα »
The Management of the Internal Piriform Apex Sinus Tract of a Branchial Pouch Anomaly and Case Description
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 ώρες
A Review Over the Past 15 Years of the Management of the Internal Piriform Apex Sinus Tract of a Branchial Pouch Anomaly and Case Description: Objectives: Literature review of treating the piriform apex sinus tract through microlaryngoscopy and a case description. Review Methods: Fourteen papers were identified in PubMed using the search criteria of piriform sinus fistula, microlaryngoscopic repair, and endoscopy. Institutional Review Board approval was obtained. Results: One hundred forty-five cases including ours were available for review, with 182 procedures. Sixty-two cases w...περισσότερα »
