Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τρίτη 28 Μαρτίου 2017

Systematic review and meta-analysis of venous thromboembolism in otolaryngology–head and neck surgery

Abstract

Background

The purpose of this study was to present our systematic review and meta-analysis of the data on venous thromboembolism (VTE; deep venous thrombosis [DVT] and/or pulmonary embolism [PE]) in otolaryngology–head and neck surgery (OHNS).

Methods

PubMed and Scopus databases were searched for studies reporting VTE in OHNS. Incidence of VTE and bleeding is reported and meta-analyzed overall and for chemoprophylaxis and squamous cell carcinoma (SCC)/free flap subgroups.

Results

A total of 23 studies were included with a total of 618,264 patients. Incidence of VTE was 0.4%. The incidence of bleeding complications was 0.9%. The addition of chemoprophylaxis did not result in a decreased VTE incidence (odds ratio [OR], 0.86), but produced an increased risk of bleeding (OR, 3.78). The overall OR for VTE in SCC/free flap cases was 6.28.

Conclusion

Chemoprophylaxis may not be necessary in the OHNS non-SCC or free flap patient population and must be balanced against an increased risk of bleeding. © 2017 Wiley Periodicals, Inc. Head Neck, 2017



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Improving outcomes in veterans with oropharyngeal squamous cell carcinoma through implementation of a multidisciplinary clinic

Abstract

Background

Treatment of head and neck cancer is complex, and a multidisciplinary clinic may improve the coordination of care. The value of a head and neck multidisciplinary clinic has not yet been established in oropharyngeal squamous cell carcinoma (SCC).

Methods

A retrospective review was conducted of Veterans Affairs patients with oropharyngeal SCC undergoing concurrent chemoradiation before and after implementation of the head and neck multidisciplinary clinic.

Results

Fifty-two patients before and 54 patients after multidisciplinary clinic were included in this study. Age, tobacco use, and p16+ status were similar between groups. With multidisciplinary clinic, time to treatment decreased, and utilization of supportive services, including speech pathology, dentistry, and nutrition increased. The 5-year disease-specific survival rate increased from 63% to 81% (p = .043) after implementation of the multidisciplinary clinic. Multivariate analysis showed that disease stage (p = .016), p16 status (p = .006), and multidisciplinary clinic participation (p = .042) were predictors of disease-specific survival.

Conclusion

Implementation of a multidisciplinary clinic improved care coordination and disease-specific survival in patients with oropharyngeal SCC. © 2017 Wiley Periodicals, Inc. Head Neck, 2017



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Impact of total radiotherapy dose on survival for head and neck Merkel cell carcinoma after resection

Abstract

Background

Head and neck Merkel cell carcinoma (MCC) is commonly treated with surgery and adjuvant radiotherapy (RT) for high-risk features. The optimal radiation dose is unknown.

Methods

One thousand six hundred twenty-five eligible patients with head and neck MCC were identified in the National Cancer Data Base (NCDB). Radiation dose was divided into 3 groups: 30 to <50 Gray (Gy), 50-55 Gy, and >55-70 Gy. Cox regression was used to compare overall survival (OS) between groups, accounting for age, sex, stage, surgery type, margin status, comorbidities, and use of chemotherapy.

Results

With a median follow-up of 33.5 months, 3-year OS was 48.9%, 70.3%, and 58.7% for 30 to <50 Gy, 50-55 Gy, and >55-70 Gy, respectively (P < .001). Compared to 50-55 Gy, doses between 30 to <50 Gy (adjusted hazard ratio [HR] 1.53; 95% confidence interval [CI] 1.17-1.99; P = .002) and >55-70 Gy (adjusted HR 1.21; 95% CI 1.0-1.46; P = .06) were associated with worse survival.

Conclusion

Adjuvant radiation doses within 50-55 Gy may be optimal for head and neck MCC.



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Endocavitary sonography of early oral cavity malignant tumors

Abstract

Background

Preoperative staging is crucial for oral cancer management. The purpose of this study was to assess the tumor thickness using ultrasound and to correlate the level of histological infiltration with the tumor superficial extension and lesion thickness.

Methods

Thirty-two subjects affected by oral cavity carcinoma were prospectively evaluated with intraoral ultrasound. The ultrasound sensitivity, the correlation between the ultrasound level of infiltration, and lesion diameters and thickness were assessed.

Results

A 91% ultrasound sensitivity was found with no significant correlation between tumor diameter and level of histological infiltration (P >.05). A thickness of <2 mm was associated to tumor extension to the lamina propria, a value of >6 mm to muscular layer infiltration. Lymph adenopathies were identified in 21% of cases, associated to muscular layer infiltration in all cases.

Conclusion

In the study of early oral cavity tumors, ultrasound is accurate for demonstrating the level of tumor infiltration and contributes to the therapeutic choice.



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Developing a risk stratification tool for audit of outcome after surgery for head and neck squamous cell carcinoma

Abstract

Background

Patients treated surgically for head and neck squamous cell carcinoma (HNSCC) represent a heterogeneous group. Adjusting for patient case mix and complexity of surgery is essential if reporting outcomes represent surgical performance and quality of care.

Methods

A case note audit totaling 1075 patients receiving 1218 operations done for HNSCC in 4 cancer networks was completed. Logistic regression, decision tree analysis, an artificial neural network, and Naïve Bayes Classifier were used to adjust for patient case-mix using pertinent preoperative variables.

Results

Thirty-day complication rates varied widely (34%-51%; P < .015) between units. The predictive models allowed risk stratification. The artificial neural network demonstrated the best predictive performance (area under the curve [AUC] 0.85).

Conclusion

Early postoperative complications are a measurable outcome that can be used to benchmark surgical performance and quality of care. Surgical outcome reporting in national clinical audits should be taking account of the patient case mix.



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Narrow-band imaging in transoral laser surgery for early glottic cancer in relation to clinical outcome

Abstract

Background

The purpose of this study was to validate the prognostic value of adding narrow-band imaging (NBI) during transoral laser surgery (TLS) for early glottic cancer.

Methods

In 84 patients, 93 transoral laser resections were performed for carcinoma in situ (Tcis), T1, or T2 glottic cancer. TLS was preceded by intraoperative evaluation using traditional white-light imaging (WLI) in 51 cases. In 42 cases, NBI was used in addition to WLI. Local recurrence rate and recurrence-free survival were retrospectively compared between both groups.

Results

Local recurrences developed in 14% of the 93 cases: 12 of 51 patients (24%) were treated by TLS based on WLI alone, and in 1 of 42 patients (2%) in the NBI group (P < .01). Two-year recurrence-free survival was 82% in the WLI group and 98% in the NBI group (P < .05).

Conclusion

Additional use of NBI during TLS for early glottic cancer significantly improves clinical outcome.



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Preoperative vitamin D level as predictor of post-thyroidectomy hypocalcemia in patients sustaining transient parathyroid injury

Abstract

Background

Several studies have sought to identify predictors of postoperative hypocalcemia after total thyroidectomy; however, there have been conflicting results regarding the impact of preoperative vitamin D deficiency.

Methods

The medical records of patients undergoing total thyroidectomy were retrospectively reviewed. The number of parathyroid glands identified or reimplanted at the time of surgery was used as a marker of transient parathyroid gland damage.

Results

Sixty-seven patients were included in the study. Vitamin D deficiency was a significant predictor of hypocalcemia in patients in whom ≥3 parathyroid glands were identified, but not in patients in whom 0-2 parathyroid glands were identified intraoperatively (odds ratio [OR] 5.8; P = .036).

Conclusion

Vitamin D deficiency is a significant predictor of postoperative hypocalcemia in patients in whom ≥3 parathyroid glands are identified intraoperatively, but not in patients who sustain minimal transient damage to the parathyroid glands.



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Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis.

Purpose of review: Animal models published within the past 18 months on asthma, food allergy and anaphylaxis, all conditions of rising public health concern, were reviewed. Recent findings: While domestic animals spontaneously develop asthma, food allergy and anaphylaxis, in animal models, divergent sensitization and challenge routes, dosages, intervals and antigens are used to induce asthmatic, food allergic or anaphylactic phenotypes. This must be considered in the interpretation of results. Instead of model antigens, gradually relevant allergens such as house dust mite in asthma, and food allergens like peanut, apple and peach in food allergy research were used. Novel engineered mouse models such as a mouse with a T-cell receptor for house dust mite allergen Der p 1, or with transgenic human hFc[gamma]R genes, facilitated the investigation of single molecules of interest. Whole-body plethysmography has become a state-of-the-art in-vivo readout in asthma research. In food allergy and anaphylaxis research, novel techniques were developed allowing real-time monitoring of in-vivo effects following allergen challenge. Networks to share tissues were established as an effort to reduce animal experiments in allergy which cannot be replaced by in-vitro measures. Summary: Natural and artificial animal models were used to explore the pathophysiology of asthma, food allergy and anaphylaxis and to improve prophylactic and therapeutic measures. Especially the novel mouse models mimicking molecular aspects of the complex immune network in asthma, food allergy and anaphylaxis will facilitate proof-of-concept studies under controlled conditions. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.

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Brief alcohol intervention in alcohol involved facial fracture patients—a survey of patient attitudes to screening and intervention

Abstract

Purpose

Alcohol intoxication is an important contributor to traumatic facial injuries. The period following injuries afford clinicians a useful window of opportunity to provide alcohol screening and brief intervention (SBI) which may affect changes in patients' future drinking behaviour. Although SBI has been reported to decrease at risk drinking and potentially trauma recurrence, it is not routinely utilised in most clinical settings in the world. This study aims to assess utilisation of, as well as patients' knowledge and attitude towards SBI in the management of patients presenting with alcohol-related facial fractures.

Methods

Twenty consecutive patients who presented to Western Health with facial fractures who met selection criteria were offered an alcohol screening and survey questionnaire.

Results

Ninety percent of patients were male and 50% were aged between 19 and 34. ASSIST score showed 65% were in the moderate risk category; 75% reported this was their first admission with alcohol related trauma. Although 75% acknowledged alcohol as a main cause of injury, only 40% agreed they drink too much. Forty-four percent felt that talking to a healthcare worker might help and 33% would consider accepting help. Forty-seven percent felt reading materials would be helpful in changing future drinking habits. Whilst 63% would like to know safe drinking limit, only 45% would like to have a discussion about alcohol-related harms.

Conclusions

Most patients presented in this survey were in moderate risk category who are amenable to behavioural change with provision of SBI. However, there is resistance to implementation of this intervention due to lack of knowledge, self-awareness and willingness to change. Nonetheless, patients are prepared to accept advice from clinicians and some formats of intervention. It is important to formulate a simple screening questionnaire and intervention strategy that are easy to administer to affect positive changes in patients with harmful drinking behaviours.



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Is Firearm Threat in Intimate Relationships Associated with Posttraumatic Stress Disorder Symptoms Among Women?

Violence and Gender , Vol. 0, No. 0.


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A second case of pericardial mesothelioma mimicking systemic lupus erythematosus in the literature in over 30 years: a case report

Mesothelioma is a rare neoplasm which commonly develops in the pleura of people exposed to asbestos. Pericardial mesothelioma accounts for only 0.7 % of all malignant mesotheliomas and it usually presents with...

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Severe Asthma in Children

Abstract

Purpose of Review

The aim of this study is to characterize, diagnose, evaluate, and treat severe childhood asthma.

Recent Findings

Understanding the occurrence of the physiologic and clinical presentations of childhood severe asthma, the treatment and response may be predicted by biomarkers, but the patient's response is highly variable.

Summary

The onset of severe asthma occurs early and is primarily predicted by severity of viral infection and coexistence of the atopic state.



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Brief alcohol intervention in alcohol involved facial fracture patients—a survey of patient attitudes to screening and intervention

Abstract

Purpose

Alcohol intoxication is an important contributor to traumatic facial injuries. The period following injuries afford clinicians a useful window of opportunity to provide alcohol screening and brief intervention (SBI) which may affect changes in patients' future drinking behaviour. Although SBI has been reported to decrease at risk drinking and potentially trauma recurrence, it is not routinely utilised in most clinical settings in the world. This study aims to assess utilisation of, as well as patients' knowledge and attitude towards SBI in the management of patients presenting with alcohol-related facial fractures.

Methods

Twenty consecutive patients who presented to Western Health with facial fractures who met selection criteria were offered an alcohol screening and survey questionnaire.

Results

Ninety percent of patients were male and 50% were aged between 19 and 34. ASSIST score showed 65% were in the moderate risk category; 75% reported this was their first admission with alcohol related trauma. Although 75% acknowledged alcohol as a main cause of injury, only 40% agreed they drink too much. Forty-four percent felt that talking to a healthcare worker might help and 33% would consider accepting help. Forty-seven percent felt reading materials would be helpful in changing future drinking habits. Whilst 63% would like to know safe drinking limit, only 45% would like to have a discussion about alcohol-related harms.

Conclusions

Most patients presented in this survey were in moderate risk category who are amenable to behavioural change with provision of SBI. However, there is resistance to implementation of this intervention due to lack of knowledge, self-awareness and willingness to change. Nonetheless, patients are prepared to accept advice from clinicians and some formats of intervention. It is important to formulate a simple screening questionnaire and intervention strategy that are easy to administer to affect positive changes in patients with harmful drinking behaviours.



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Spontaneous resolution of hypercalcemia

Primary hyperparathyroidism (PHPT) is a frequently encountered endocrine disorder due to benign neoplastic lesions or gland hyperplasia. It is often discovered incidentally when routine lab work reveals hypercalcemia.

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Mechanical mandible competence in rats with nutritional growth retardation

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Publication date: August 2017
Source:Archives of Oral Biology, Volume 80
Author(s): Christian Esteban Lezón, Patricia Mabel Pintos, Clarisa Bozzini, Alan Agüero Romero, Patricia Casavalle, Silvia María Friedman, Patricia Mónica Boyer
ObjectiveIn order to provide a better understanding of the sympathetic nervous system as a negative regulator of bone status, the aim of the study was to establish the biomechanical mandible response to different doses of a β-adrenergic antagonist such as propranolol (P) in a stress-induced food restriction model of growth retardation.MethodsRats were assigned to eight groups: Control (C), C+P3.5 (CP3.5), C+P7 (CP7), C+P14 (CP14), NGR, NGR+P3.5 (NGRP3.5), NGR+P7 (NGRP7) and NGR+P14 (NGRP14). C, CP3.5, CP7 and CP14 rats were freely fed with the standard diet. NGR, NGRP3.5, NGRP7 and NGRP14 rats received, for 4 weeks (W4), 80% of the amount of controls food consumed. Propranolol 3.5, 7 and 14mg/kg/day was injected ip 5days per week in CP3.5 and NGRP3.5, CP7 and NGRP7, CP14 and NGRP14, respectively. At W4, zoometry, mandible morphometry, static histomorphometric and biomechanical competence were performed.ResultsA dose of Propranolol 7mg/kg/day induced interradicular bone volume accretion reaching a mandible stiffness according to chronological age.ConclusionThese findings evidenced that sympathetic nervous system activity is a negative regulator of mandible mechanical competence in the nutritional growth retardation model. Propranolol 7mg/kg/day, under the regimen usage, seems to be appropriate to blockade SNS activity on mandible mechanical performance in NGR rats, probably associated to an effect on bone mechanostat system ability to detect disuse mode as an error.



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Mechanical mandible competence in rats with nutritional growth retardation

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Publication date: August 2017
Source:Archives of Oral Biology, Volume 80
Author(s): Christian Esteban Lezón, Patricia Mabel Pintos, Clarisa Bozzini, Alan Agüero Romero, Patricia Casavalle, Silvia María Friedman, Patricia Mónica Boyer
ObjectiveIn order to provide a better understanding of the sympathetic nervous system as a negative regulator of bone status, the aim of the study was to establish the biomechanical mandible response to different doses of a β-adrenergic antagonist such as propranolol (P) in a stress-induced food restriction model of growth retardation.MethodsRats were assigned to eight groups: Control (C), C+P3.5 (CP3.5), C+P7 (CP7), C+P14 (CP14), NGR, NGR+P3.5 (NGRP3.5), NGR+P7 (NGRP7) and NGR+P14 (NGRP14). C, CP3.5, CP7 and CP14 rats were freely fed with the standard diet. NGR, NGRP3.5, NGRP7 and NGRP14 rats received, for 4 weeks (W4), 80% of the amount of controls food consumed. Propranolol 3.5, 7 and 14mg/kg/day was injected ip 5days per week in CP3.5 and NGRP3.5, CP7 and NGRP7, CP14 and NGRP14, respectively. At W4, zoometry, mandible morphometry, static histomorphometric and biomechanical competence were performed.ResultsA dose of Propranolol 7mg/kg/day induced interradicular bone volume accretion reaching a mandible stiffness according to chronological age.ConclusionThese findings evidenced that sympathetic nervous system activity is a negative regulator of mandible mechanical competence in the nutritional growth retardation model. Propranolol 7mg/kg/day, under the regimen usage, seems to be appropriate to blockade SNS activity on mandible mechanical performance in NGR rats, probably associated to an effect on bone mechanostat system ability to detect disuse mode as an error.



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For assessment of changes in intraoperative red blood cell transfusion practices over time, the pooled incidence of transfusion correlates highly with total units transfused

Multiple studies nationwide and at single hospitals have examined changes over time in the incidence of perioperative red blood cell (RBC) transfusion. However, the cost of RBC transfusions is related to the number of RBC units transfused, not to the incidence. We evaluate whether the readily available incidence of RBC transfusion can be used as a valid surrogate measure.

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Has the primary care oral surgery service reduced the activity in secondary care oral and maxillofacial units?

To find out if the devolution of some dentoalveolar services into primary care in 2007 was having an effect on the workload of oral and maxillofacial units, I reviewed the workload of two units in 2011-13.

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Chemocauterization of second branchial cleft fistula using trichloroacetic acid: A preliminary report

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Publication date: Available online 27 March 2017
Source:Auris Nasus Larynx
Author(s): Bo Hae Kim, Seong Keun Kwon, J.Hun Hah
ObjectiveAlthough second branchial cleft fistula (BCF) can be well treated with surgical excision, neck scarring is unavoidable. We previously reported chemocauterization with trichloroacetic acid (TCA) to close various fistulas. Here, we report chemocauterization of a second BCF without a consequent incision scar.MethodsThis procedure was applied in four pediatric patients whose parents were reluctant to undergo surgical excision for a second BCF. Under general anesthesia, a thin metal suction tip or cut down tube was inserted through the skin opening. Normal saline with or without dye was injected to identify the pharyngeal opening around the palatine tonsil, and 75% TCA solution mixed with dye was injected. Leaked TCA at the pharynx was sucked out meticulously to avoid extensive and unexpected injury to the mucosa, and the external opening was sealed with a thin adhesive film.ResultsThere were no immediate complications and recurrence of a second BCF in all patients during the median follow-up of 23 months (range, 18–88 months) with minimal neck scarring.ConclusionTCA chemocauterization of second BCF could be a simple, less invasive, and feasible treatment option in pediatric patients.



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Sialendoscopic removal of fish bone-induced sialoliths in the duct of the submandibular gland

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Publication date: Available online 27 March 2017
Source:Auris Nasus Larynx
Author(s): Toshinori Iwai, Satomi Sugiyama, Yuichiro Hayashi, Senri Oguri, Makoto Hirota, Kenji Mitsudo, Iwai Tohnai
Obstructive sialadenitis of the submandibular gland is commonly caused by sialoliths, but more rarely by foreign body-induced sialoliths. Here, we report minimally invasive sialendoscopic removal of fish bone-induced sialoliths in the duct of the submandibular gland. A 43-year-old woman presented with recurrent swelling of the right submandibular gland at other hospital. Computed tomography (CT) showed an 8-mm linear calcification in the posterior part of Wharton's duct. The lesion was deemed difficult to remove and she was followed up. However, because the lesion did not resolve spontaneously within 9 months and chronic sialadenitis symptoms persisted, she was referred to our department for endoscopic removal. CT showed a linear calcification (5.6×1.2×0.8mm) connecting 2 spherical calcifications (2.3×2.1×1.9mm; 1.8×1.4×1.1mm) in the anterior part of Wharton's duct. The patient underwent endoscopic removal of the lesion using a 1.6-mm-diameter sialendoscope under local anesthesia. The specimen contained a fish bone connecting 2 sialoliths. The patient was unaware of the fish-bone injury. After removal, there was no recurrence of submandibular gland swelling during 6 months follow-up.



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The indication for endoscopic butterfly cartilage myringoplasty in children

We have reviewed the manuscript entitled "Endoscopic cartilage butterfly myringoplasty in children" by Akyigit et al. [1]. The authors evaluated the results of the graft success rate and hearing gain of children who underwent endoscopic inlay butterfly myringoplasty due to chronic otitis media. The authors concluded that endoscopic inlay butterfly tympanoplasty is a surgical technique with short duration, high graft success, effective hearing reconstruction, and high levels of postoperative patient comfort in children [1].

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Partial cricotracheal resection for severe upper tracheal stenosis: Potential impacts on the outcome

The aim of this study was to investigate the potential impact of multiple preoperative and intraoperative variables on the outcome of partial cricotracheal resection and tracheal resection anastomosis (PCTR/TRA).

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Effect of Occlusal Plane correction on Lip Cant in two-jaw orthognathic surgery – A Three-dimensional analysis

The aim of the present study was to evaluate the impact of canting correction in occlusal plane (OP) on the change of lip cant (LC) using three-dimensional (3D) photogrammetry in combination with cone-beam computed tomographic (CBCT) scans in class III asymmetric patients.

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Three-dimensional surface scanners compared with standard anthropometric measurements for head shape

Three-dimensional (3D) surface imaging devices designed to capture and quantify craniofacial surface morphology are becoming more common in clinical environments. Such scanners overcome the limitations of two-dimensional photographs while avoiding the ionizing radiation of computed tomography. The purpose of this study was to compare standard anthropometric cranial measurements with measurements taken from images acquired with 3D surface scanners.Two 3D scanners of different cost were used to acquire head shape data from thirteen adult volunteers: M4D scan and Structure Sensor.

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An Italian multicentre experience in endoscopic endonasal treatment of congenital choanal atresia: proposal for a novel classification system of surgical outcomes

The purposes of this study were to report our experience with endoscopic treatment of choanal atresia (CA), to illustrate our surgical technique and analyse the different factors that may affect outcomes.

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Modification of cytokine-induced killer cells with folate receptor alpha (FRα)-specific chimeric antigen receptors enhances their antitumor immunity toward FRα-positive ovarian cancers

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Publication date: May 2017
Source:Molecular Immunology, Volume 85
Author(s): Shuguang Zuo, Yuqing Wen, Hean Panha, Gongpeng Dai, Liping Wang, Xuequn Ren, Kanda Fu
Folate receptor alpha (FRα) is aberrantly expressed in ovarian cancers but largely absent in normal tissues, and therefore represents an attractive target for immunotherapy. In recent years, modification of T cells with chimeric antigen receptor (CAR) targeting FRα has been reported to improve antitumor immunity of T cells. However, there are limited data regarding CAR-modified cytokine-induced killer (CAR-CIK) cells. In the present study, we modified CIK cells with FRα-specific CARs and investigated their antitumor immunity against ovarian cancers. We found that both non-transduced and mock CAR-transduced CIK cells showed only low antitumor activity against either FRα-positive (FRα+) or FRα-negative (FRα) targets. However, all three generations of CAR-modified CIK cells showed enhanced antitumor activity against FRα+ targets, but not FRα targets. First-generation ζ-CAR-CIK cells increased production of IFN-γ, enhanced short-term cytotoxicity against FRα+ ovarian cancer cells, and showed modest and short-term suppression of established tumors; while second-generation 28ζ- and third-generation 28BBζ-CAR-CIK cells showed significant proliferation, enhanced secretion of IL-2, eliminated the FRα+ ovarian cancer cells in long-term co-culture, and showed dramatic and long-term inhibition of tumor growth and prolonged survival of xenograft-bearing mice. It is noteworthy that the 28BBζ-CAR was more potent in the modification of CIK cells than 28ζ-CAR both in vitro and in vivo. Moreover, CAR-CIK cells showed more efficient anticancer activity compared with CAR-T cells in vitro, but less efficient than CAR-T cells in vivo. According to these results, we conclude that modification of CIK cells with FRα-specific CARs enhances their antitumor immunity to FRα+ ovarian cancers. The third-generation 28BB-ζ CAR containing 4-1BB co-stimulation was more efficient in modification of CIK cells than either first-generation ζ-CAR or second-generation CD28-ζ-CAR.



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FcγRIIb expression on B cells is associated with treatment efficacy for acute rejection after kidney transplantation

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Publication date: May 2017
Source:Molecular Immunology, Volume 85
Author(s): Juan Jin, Jianguang Gong, Bo Lin, Yiwen Li, Qiang He
BackgroundFcγ receptors (FcγR) play a role in the acute rejection (AR) of organ transplants. FcγRIIB is an inhibitory FcγR expressed on B cells. Intravenous IgG (IVIG) and CD28 monoclonal antibody (mAb) have been shown to have immunomodulatory properties against AR.AimTo examine the association between FcγRIIB expression on B cell subpopulations and AR treatment efficacy.MethodsMale F344 rats were used as kidney donors and Lewis rats as recipients to establish models of renal transplantation. Rats were divided into five groups: sham, AR-PBS, AR-IVIG, AR-PNGase F-IVIG, and AR-CD28. Serum creatinine (Scr), blood urea nitrogen (BUN), and urine protein content were determined. Inflammatory markers were measured by ELISA, FcγR by western blotting, and spleen B cell activation by flow cytometry.ResultsScr, BUN, urinary protein content, levels of CRP, IL-10, TNF-α, IL-6, IL-8, and IgG were all increased in the AR-PBS group compared with the sham group (all P<0.01); these increases were partly reversed in the AR-IVIG, AR-PNGase F IVIG, and AR-CD28 groups (all P<0.01), with IVIG showing the better efficacy than PNGase F IVIG. Furthermore, blood and spleen FcγRIA and FcγRIIIA were increased by AR, while FcγRIIB expressions in splenic activated B cells and regulatory B cells were decreased; these changes were partly alleviated by all three treatments, with IVIG having the better effect than PNGase F IVIG.ConclusionWe observed an association between B cell FcγRIIB expression and treatment efficacy for AR after kidney transplantation in rats.



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FDA Approves Dupilumab (Dupixent) for Eczema

Designated a breakthrough therapy, dupilumab spares patients with moderate to severe eczema from the need to resort to systemic immunosuppressants and the higher risks they pose.
FDA Approvals

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External ear findings during anaphylaxis



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Worst Pattern Of Invasion and occult cervical metastases for oral squamous carcinoma

ABSTRACT

Background

The Risk Model is a validated prognostic schema for patients with oral cavity squamous carcinoma. Here, we examine the relationship between Worst Pattern of Invasion-type 5 (WPOI-5) and occult cervical metastases, and also present an interim observational analysis of the impact of adjuvant radiotherapy on patients with low-stage oral cancer classified as either high risk or WPOI-5 alone.

Methods

There were 323 patients with T1T2cNo oral cavity squamous carcinoma treated by primary resection, 152 of whom also underwent elective neck dissection (END). The resection specimens were examined for worst pattern of invasion, perineural invasion, and lymphocytic host responses, and classified as low risk, intermediate risk, or high risk. Fisher's 2-tailed exact test and Kaplan–Meier outcome analyses were performed.

Results

High-risk classification is significantly associated with decreased time to local recurrence (p = .0128; hazard ratio [HR], 2.82; 95% confidence interval [CI], 1.22–6.5) and regional metastasis (p = .052; HR, 3.27; 95% CI, 1.42–7.5). For patients undergoing END, 31 (20%) had occult-positive lymph nodes. WPOI-5 is significantly predictive of occult cervical metastases (p < .0001). We examined the impact of adjuvant radiotherapy on the WPOI-5 subgroup (n = 55). Despite being underpowered, Kaplan–Meier curves demonstrate good separation between patients with low-stage WPOI-5 who received postoperative adjuvant radiotherapy versus those treated by surgery alone, with respect to disease-specific mortality and disease-free survival.

Conclusion

WPOI-5 is significantly predictive of occult metastatic disease in cervical lymph nodes. Interim analysis of patients with low-stage WPOI-5 for the impact of adjuvant radiotherapy justifies continuing patient accrual in an observational setting. These data can ultimately support a clinical trial for more aggressive treatment in this niche group. © 2017 Wiley Periodicals, Inc. Head Neck, 2017



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Risk factors for and the role of dental extractions in osteoradionecrosis of the jaws: A national-based cohort study

ABSTRACT

Background

The purpose of this study was to investigate the risk factors, especially the use of certain drugs and the dental procedures, for osteoradionecrosis of the jaw (ORNJ) in patients with head and neck cancer undergoing irradiation as their primary treatment.

Methods

The cohort was composed of 23,527 patients with head and neck cancer. Cox proportional hazard models were used for risk factors analysis.

Results

The overall incidence of ORNJ is 3.93 per 100 person-years. Buccal cancer carried the highest ORNJ risk. The use of steroids had a protective effect. Preradiotherapy extraction posed no excess risk, whereas postradiotherapy extraction was associated with gradually increased risk of ORNJ over time that peaked at 4 to 5 years.

Conclusion

ORNJ warrants life-long attention for head and neck cancer survivors. The present study strongly confirms the role of preirradiation dental extractions. Meanwhile, efforts should be made to prevent posttreatment extractions, especially in the first posttreatment 4 years. © 2017 Wiley Periodicals, Inc. Head Neck, 2017



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p16INK4a: A surrogate marker of high-risk human papillomavirus infection in squamous cell carcinoma of the nasal vestibule

Abstract

Background

The purpose of this study was to analyze the role of p16INK4a and the prevalence of human papillomavirus (HPV) in squamous cell carcinoma (SCC) of the nasal vestibule.

Methods

Patients diagnosed from 1995 to 2014 were included in this study. Assessment of p16INK4a and HPV-DNA polymerase chain reaction (PCR) was performed and analyzed with respect to baseline, clinicopathological, and outcome parameters. The p16INK4a positivity was defined as unequivocal nuclear and cytoplasmic staining of ≥70% of the cells, whereas 50%-69% was considered to be a "borderline" result.

Results

There were 46 patients with SCCs of the nasal vestibule, of whom 31 (67.4%) were available for p16INK4a and 30 (65.2%) for analysis of HPV. Expression of p16INK4a was present in 19.4% and showed coincidence with high-risk HPV (P < .001). Neither p16INK4a nor HPV-DNA had significant impact on outcome.

Conclusion

Significant immunoreactivity for p16INK4a was present in about one-fifth of the samples and figured as a surrogate marker of high-risk HPV infection. There was no influence on outcome.



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Unknown primary head and neck squamous cell carcinoma in the era of fluorodeoxyglucose-positron emission tomography/CT and intensity-modulated radiotherapy

Abstract

Background

The diagnosis and treatment of head and neck carcinoma of unknown primary (CUP) have changed with the introduction of fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT and intensity-modulated radiotherapy (IMRT), with potential implications for outcome.

Methods

We conducted a retrospective analysis of 80 patients with head and neck CUP who were PET-staged and treated with curative intention using IMRT between 2006 and 2016 in the Netherlands Cancer Institute. Patient, tumor, and treatment demographics were recorded and oncologic outcomes were analyzed.

Results

Local control was 100% in mucosal irradiated patients. Regional control was 90%. Ten patients developed distant metastases, which were associated with N3, extracapsular extension (ECE) and lower neck positive lymph nodes. Overall survival (OS) at 5 years was 62% and disease-specific survival was 78%. ECE, N3 neck, multiple levels of positive lymph nodes, and positive lymph nodes in the lower neck were associated with worse prognosis.

Conclusion

Locoregional outcome of head and neck CUP managed with modern techniques is good. Future research needs to focus on reducing toxicity and patients prone for distant metastasis.



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Preoperative evaluation and surgical planning of submandibular gland tumors

Abstract

Background

Roughly half of submandibular gland neoplasms are malignant. Because preoperative information on the nature of these tumors remains limited, both preoperative evaluation and assessment of the extent of primary surgery warrant guidelines that are more accurate.

Methods

We evaluated the preoperative examinations and management of all submandibular gland neoplasms treated surgically at the Helsinki University Hospital between 2000 and 2010.

Results

Of the 83 tumors, 58 (70%) were benign and 25 (30%) were malignant. Of the benign tumors, 54 (93%) were pleomorphic adenomas. The cytology in 8 patients (10%) was class IV or V, and in 12 patients was class III; the tumors in 9 of these 12 patients turned out to be malignant. Of all malignancies, 10 (40%) required additional more extensive surgery.

Conclusion

Ultrasound-guided fine-needle aspiration cytology (FNAC) proved useful, with limitations, in preoperative examination. Surgeons should always obtain wide margins whenever possible, even when clinical means or cytology indicates no malignancy. © 2017 Wiley Periodicals, Inc. Head Neck, 2017



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High-dose or low-dose cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer

Abstract

Background

No randomized studies have compared low-dose or high-dose concurrent chemoradiotherapy (CRT).

Methods

In this study, 7219 patients with stage III or IV head and neck squamous cell carcinoma (HNSCC) were enrolled and categorized into 2 groups: group 1, comprising those undergoing low-dose concurrent CRT (n = 1575), and group 2, comprising those receiving high-dose concurrent CRT (n = 5644).

Results

Cox regression analyses revealed that age ≥65 years, male, high Charlson comorbidity index (CCI) scores, radiotherapy (RT) duration ≥7.5 weeks, clinical stage IV cancer, oral cavity cancers, tobacco smoking, and total cisplatin dose ≥240 mg/m2 were significant independent prognostic risk factors for overall survival (OS). After adjustment for confounders, the adjusted hazard ratio (aHR; 95% confidence interval [CI]) for overall mortality was 0.83 (0.78-0.89; P < .001) in patients with oral cavity HNSCC undergoing high-dose concurrent CRT and 0.82 (0.77-0.94; P < .001) in patients with nonoral cavity HNSCC receiving high-dose concurrent CRT.

Conclusion

High-dose concurrent CRT can reduce the incidence of death in patients with stage III or IV HNSCC.



http://ift.tt/2ocQ3Ar

T1 Squamous cell carcinoma of the glottis with anterior commissure involvement: Radiotherapy versus transoral laser microsurgery

Abstract

Background

The optimal treatment method of T1 glottic squamous cell carcinoma (SCC) with involvement of the anterior commissure is still debatable. We compared the outcomes of radiotherapy (RT) and transoral laser microsurgery (TLM).

Methods

Data were retrospectively collected for 54 patients who were treated by RT (n = 38) or TLM (n = 16) from 2006 to 2013.

Results

No between-group differences were found in demographic or risk factors. Recurrence was noted in 6 patients of the TLM group and 5 of the RT group. There was a near-significant association of TLM with recurrence (p = .053). Radiation was associated with a higher 5-year disease-free survival (DFS) (87.3% vs 74.9%; p = .037). Both groups had excellent rates for local control (75% and 97%, respectively), and overall survival (78.9 and 87.5%, respectively). There were no significant differences in outcome parameters by tumor classification.

Conclusion

TLM is associated with higher recurrence rates and lower DFS. Both patients with T1a and T1b disease had the same outcome parameters. © 2017 Wiley Periodicals, Inc. Head Neck, 2017



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Regulation of hemodynamics in major salivary glands by parasympathetic vasodilation

Publication date: Available online 28 March 2017
Source:Journal of Oral Biosciences
Author(s): Toshiya Sato, Hisayoshi Ishii
BackgroundSince salivary fluid is created from blood plasma, hemodynamics in the salivary glands play an important role in the production of saliva. Trigeminal sensory input induces both salivary secretion and reflex parasympathetic vasodilation in salivary glands. This glandular vasodilation is thought to be important for the regulation of glandular hemodynamics due to the rapidity with which blood flow is increased. This review article summarizes recent research on the involvement of parasympathetic vasodilation in regulating hemodynamics in the salivary gland.HighlightElectrical stimulation of the lingual nerve, a branch of the trigeminal nerve, elicits parasympathetic vasodilation in the salivary glands. Parasympathetic vasodilation is mainly evoked by cholinergic fibers in the submandibular and parotid glands and by cholinergic and vasoactive intestinal peptide (VIP)-ergic fibers in the sublingual gland. The vasodilator mechanism changes from cholinergic to VIP-ergic when muscarinic receptors are deactivated.ConclusionGlandular hemodynamics in the submandibular, parotid, and sublingual glands are regulated by different parasympathetic vasodilator mechanisms, which may functionally contribute to the differences in secretion among the major salivary glands.



http://ift.tt/2od9glz

Severe Asthma in Children

Abstract

Purpose of Review

The aim of this study is to characterize, diagnose, evaluate, and treat severe childhood asthma.

Recent Findings

Understanding the occurrence of the physiologic and clinical presentations of childhood severe asthma, the treatment and response may be predicted by biomarkers, but the patient's response is highly variable.

Summary

The onset of severe asthma occurs early and is primarily predicted by severity of viral infection and coexistence of the atopic state.



http://ift.tt/2nwvEbr

Histological, immunohistological and molecular characteristics of intraductal precursor of carcinoma ex pleomorphic adenoma support a multistep carcinogenic process

Abstract

In recent years, multistep carcinogenesis of carcinoma ex pleomorphic adenoma (CEPA) has been identified, starting with intraductal neoplasia within pre-existent pleomorphic adenoma (PA). However, as yet there is no consensus regarding clinical relevance and appropriate terminology of precursor lesions in CEPA. We therefore decided to investigate precursor lesions, especially intraductal carcinoma, in a series of 85 cases of CEPA. Intraductal carcinoma confined by benign myoepithelial cells was found in 60 cases and mostly exhibited high-grade cellular atypia, increased cellular proliferation and frequent genetic alterations (TP53, Her2-neu, androgen receptor). Intraductal carcinoma was absent only in the myoepithelial type of CEPA. In 26 cases, purely intraductal CEPA with extensive intraductal expansion was found. This suggests that there is a long period of intraductal growth before extraductal intracapsular infiltration of the PA. We identified two different histomorphological types of intraductal carcinoma, which we call 'clinging' and 'solid' types. In summary, combined histological, immunohistological and molecular data strongly support multistep carcinogenesis starting with intraductal carcinoma for all non-myoepithelial types of CEPA. The clinical significance of our finding of two histomorphological types of intraductal carcinoma (clinging and solid) is not yet clear. Intraductal carcinoma, intracapsular invasive CEPA and minor extracapsular invasive CEPA (up to about 6 mm) all show favourable prognosis and together comprise half of the cases in our study.



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Bildgebung zur Operationsplanung

Zusammenfassung

Die Bildgebung ist neben der klinischen Befunderhebung ein wichtiges Diagnostikum, das zur Therapieentscheidung und insbesondere zur Operationsplanung bei Kopf-Hals-Karzinomen herangezogen werden muss. Die Bedeutung und die Art der Bildgebung sind abhängig von der Lokalisation des Primärtumors. Bei jeder Bildgebung müssen neben der Darstellung des Primärtumors auch die Lymphabflusswege einbezogen werden, um ein Gesamtkonzept der operativen Therapie erstellen zu können. Neben der flächenhaften Tumorausdehnung ist von besonderer Bedeutung, auch das Tumorvolumen durch die Bildgebung zu erfassen, um dadurch das Ausmaß der Resektion und die möglicherweise notwendige Rekonstruktion zu indizieren. Die Art der Bildgebung, z. B. Computertomographie oder Magnetresonanztomographie, ist abhängig von der Tumorlokalisation. In manchen Fällen ergänzen sich beide Verfahren.



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Biological therapies in otology

Abstract

Hearing loss is present in millions of people worldwide. Current treatment for patients with severe to profound hearing loss consists of cochlear implantation. Providing the cochlear nerve is intact, patients generally benefit greatly from this intervention, frequently achieving significant improvements in speech comprehension. There are, however, some cases where current technology does not provide patients with adequate benefit. Ongoing research in cell transplantation and gene therapy promises to lead to new developments that will improve the function of cochlear implants. Translation of these experimental approaches is presently at an early stage. This review focuses on the application of biological therapies in severe hearing loss and discusses some of the barriers to translating basic scientific research into clinical reality. We emphasize the application of these novel therapies to cochlear implantation.



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Motivation for orthognathic treatment and anticipated satisfaction levels—a two-centre cross-national audit

Publication date: Available online 27 March 2017
Source:Journal of Cranio-Maxillofacial Surgery
Author(s): Raphael Patcas, Susan J. Cunningham, Justin Shute, Timothy Lloyd, Joachim A. Obwegeser, Lida Arjomand, Sujata Sharma
PurposeThis audit investigated factors which motivate patients to seek orthognathic treatment, assessed how confident patients were that they would be satisfied with the outcome of treatment, and explored possible influencing factors.Materials and MethodsQuestionnaires were distributed to pre-surgical patients at two centres (United Kingdom and Switzerland); questions asked what patients wished to gain from orthognathic treatment and how confident they were that they would be satisfied with treatment outcome. Gender, age and location were recorded as demographic variables, and type of malocclusion was also recorded.ResultsA total of 202 questionnaires were returned (UK, n=149; Switzerland, n=53). Reported motivating factors focused on improvements in aesthetics (specified and unspecified) (UK vs. Switzerland: 91.3% vs. 83.0%), function (72.5% vs. 66.0%), psychosocial health (51.7% vs. 20.8%), speech (4.0% vs. 7.5%), alleviation of pain (5.4% vs. 17%) and normalization of breathing (1.3% vs. 7.5%). No significant relationships were observed relative to patient age, gender or malocclusion. The anticipated satisfaction levels were generally high (86.5% vs. 89.9%).ConclusionAlthough the distribution of motivational factors varied between the two sites, it did not affect the anticipated satisfaction level. Patients were generally confident that they would be satisfied with their treatment outcome and that their reasons for seeking treatment would be addressed.



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Comprehensive and reliable classification system for primary diagnosis of cleft lip and palate

Publication date: Available online 27 March 2017
Source:Journal of Cranio-Maxillofacial Surgery
Author(s): Ahmed Elsherbiny, Ahmed S. Mazeed
ObjectiveDue to the lack of a universally accepted classification system, we are aiming to introduce a modified comprehensive, precise and relative simple classification system for primary diagnosis of cleft lip and palate.MethodsThe proposed classification is based on the Kernahan's striped Y diagram with more details in cleft extent and with the addition of severity scores to each cleft component. Clear definitions of cleft extents and severity degrees were described based on 400 consecutive primary cases. Two medical students were taught the classification then diagnosed photographs of 100 cases twice to test its reliability.ResultsThe students' results were 11% and 13% wrong diagnoses for student 1 and 2 in the first time, 8% and 10% in the second time, respectively. The inter-rater reliability for the two students in the first and second time was 0.716 and 0.878, respectively. The intra-rater reliability for student 1 and 2 were 0.826 and 0.755 respectively. The average duration to diagnose a case was less than a minute.ConclusionThis classification is comprehensive and records many diagnostic variables with high reliability and precision.



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Use of cutting guides during craniosynostosis sequelae surgery: A comparative study between computer-assisted planning and post-operative results

Publication date: Available online 28 March 2017
Source:Journal of Cranio-Maxillofacial Surgery
Author(s): Chrystelle Queiros, Aline Joly, Arnaud Paré, Antoine Listrat, Nadine Travers, Dominique Goga, Boris Laure




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The accuracy of patient specific implant prebented with 3D-printed rapid prototype model for orbital wall reconstruction

Publication date: Available online 27 March 2017
Source:Journal of Cranio-Maxillofacial Surgery
Author(s): Young Chul Kim, Woo Shik Jeong, Tae-kyung Park, Jong Woo Choi, Kyung S. Koh, Tae Suk Oh
BackgroundThis study evaluated the accuracy of blowout fracture reduction using 3D-printed rapid prototyping (RP) skull modeling.Patients and MethodsRetrospective review was performed for 82 patients who underwent post-traumatic orbital wall fracture reduction between 2012 and 2014. Patients were divided into two groups according to the use of 3D-printed RP skull model reproduced by mirroring technique, onto which a titanium mesh was anatomically molded. Using computed tomographic scans, the areas of pre- and post-operative orbital wall defect, the layout angles of the titanium mesh, and the gap lengths between the implant and fracture margin were compared between the two groups.ResultsOf the 82 patients identified, 46 and 36 were diagnosed with medial and inferior orbital wall fractures, respectively. Bone defect area of the RP group was significantly reduced in comparison with that of the conventional group (8.03±3.5% versus 18.7±15.41% for medial wall fractures, 7.14±5.74% versus 12.8±4.92% for inferior wall fractures, respectively, p<0.01). Satisfactory results were achieved regarding the layout angles and the gap lengths, presenting significantly reduced values in the RP group compared to that in the conventional group (p<0.01).ConclusionsMore accurate restoration of traumatic orbital wall fractures can be achieved using patient-specific 3D-printed RP skull models.



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Gender-specific evaluation of variation of maxillary exposure when smiling

Publication date: Available online 27 March 2017
Source:Journal of Cranio-Maxillofacial Surgery
Author(s): Niels Christian Pausch, Dimitrios Katsoulis
IntroductionExcessive exposure of maxillary teeth when smiling can have a negative effect on the aesthetics and attractiveness of the face. The presented study was aimed to evaluate the effect of different amounts of gingival exposure on the perception of such human characteristics and qualities as age, attractiveness, gender specificity, and felt sympathy in the context of the whole face.Materials and methodsForty-two participants (21 female and 21 male students of dental medicine) were recruited as evaluators for the study. Two average-looking subjects (one female, one male) were photographed. The images were processed to create a series of eight clones with different gingival exposure (shift A-H; A = full over-exposure, H = invisibility of the crown surfaces of the teeth).The panellists evaluated characteristics as attractiveness, gender specificity, age, and felt sympathy.Results42 participants joined the study (21 female, 21 male). Shift H was assessed as worst for sympathy and attractiveness, and resulted in the highest estimated age. Best attractiveness was observed for shifts C and D. Gender dimorphism was noticed, with own gender being rated as less attractive and opposite gender as more attractive.ConclusionsFemale and male evaluators assess excessive gingival and maxillary incisor display differently for female and male probands. Excessive over- or underexposure of the maxillary gingiva and teeth when smiling is perceived as unattractive and results in less observer sympathy.



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Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases

Conditions:   Malignant Neoplasm of Bone and Articular Cartilage;   Malignant Neoplasms of Female Genital Organs;   Malignant Neoplasms of Independent (Primary) Multiple Sites;   Malignant Neoplasms of Lip Oral Cavity and Pharynx;   Malignant Neoplasm of Male Genital Organs;   Malignant Neoplasms of Mesothelial and Soft Tissue;   Malignant Neoplasm of Respiratory and Intrathoracic Organ Carcinoma;   Malignant Neoplasms of Thyroid and Other Endocrine Glands;   Malignant Neoplasms of Urinary Tract;   Melanoma and Other Malignant Neoplasms of Skin
Intervention:   Drug: Gemcitabine
Sponsors:   M.D. Anderson Cancer Center;   James B. and Lois R. Archer Charitable Foundation;   Gateway for Cancer Research
Not yet recruiting - verified March 2017

http://ift.tt/2nqUY0Q

Measuring Patient-Reported Adverse Events in Oncology Practice Improves Quality of Life in Nasopharyngeal Carcinoma

Condition:   Nasopharyngeal Neoplasms
Interventions:   Other: adverse events using patient-reported outcomes version of common terminology criteria for adverse events (PRO-CTCAE) questionaire;   Other: do not report adverse events through patient-reported outcomes version of common terminology criteria for adverse events (PRO-CTCAE) questionaire
Sponsor:   Sun Yat-sen University
Not yet recruiting - verified March 2017

http://ift.tt/2nHRCca

Study Assessing the Effects of Chemotherapy in Advanced Esophagogastric Adenocarcinoma

Conditions:   Esophageal Neoplasms;   Stomach Neoplasms
Interventions:   Drug: Carboplatin;   Drug: Docetaxel;   Drug: Capecitabine;   Drug: Epirubicin;   Drug: Oxaliplatin
Sponsor:   Rigshospitalet, Denmark
Recruiting - verified March 2017

http://ift.tt/2nqRrQ4

Japanese guidelines for allergic diseases 2017

Publication date: April 2017
Source:Allergology International, Volume 66, Issue 2
Author(s): Ken Ohta, Kenji Izuhara




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Biosimilars and drug development in allergic and immunologic diseases

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Publication date: Available online 27 March 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Sergio Bonini, Matteo Bonini




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Evaluation of hyaluronic matrix efficacy in sinus augmentation: a randomized-controlled histomorphometric and micro–computed tomography analysis

Publication date: Available online 27 March 2017
Source:International Journal of Oral and Maxillofacial Surgery
Author(s): E. Dogan, E. Dursun, E. Tosun, E. Bilgic, A.C. Akman, K. Orhan, H.H. Celik, P. Korkusuz, F. Caglayan
The objective of the present study was to test the hypothesis that the addition of hyaluronic acid–based matrix to collagenated heterologous bone graft for sinus augmentation would enhance bone formation compared to collagenated heterologous bone graft alone in the early healing period, by micro−computed tomography and histomorphometry. Thirteen systemically healthy patients requiring bilateral two-stage maxillary sinus augmentation (residual crest height≤4mm) were enrolled in this split-mouth prospective randomized controlled study. One sinus side as a control group was grafted with only collagenated heterologous bone graft; the other region as a test group was grafted with hyaluronic matrix and collagenated heterologous bone graft. Bone biopsy samples were taken after 4 months during the dental implant surgery and analyzed using micro−computed tomography and histomorphometric parameters. According to the micro−computed tomography and histomorphometric results, a significantly higher percentage of new bone was observed in the test group when compared to the control group after 4 months of healing.This study confirmed the hypothesis that the addition of hyaluronic matrix to collagenated heterologous bone graft for sinus augmentation enhances bone formation compared to collagenated heterologous bone graft alone in the early healing period.



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Editorial Board/Reviewing Committee

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Publication date: May 2017
Source:International Journal of Oral and Maxillofacial Surgery, Volume 46, Issue 5





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Comparison of the adult three-dimensional craniofacial features of patients with unilateral craniofacial microsomia with and without early mandible distraction

Publication date: Available online 27 March 2017
Source:International Journal of Oral and Maxillofacial Surgery
Author(s): E.W.-C. Ko, P.K.-T. Chen, L.-J. Lo
This study was conducted to analyze the long-term facial growth of patients with craniofacial microsomia (CFM) after early mandible distraction osteogenesis (DO), and compared adult three-dimensional (3D) craniofacial features of patients with and without early mandibular DO for Pruzansky grade II deformities. The study included 20 patients: 9 with early mandible DO (the DO group) and 11 without previous treatment (the NDO group). Longitudinal radiographs were measured for growth changes after DO. The 3D craniofacial images were constructed to compare the craniofacial forms between the two groups. The patients with early DO presented 8 to 9mm forward and downward maxillary growth and 4.6mm limited forward and 17.3mm substantial downward mandibular growth. The ramus length ratio (affected/nonaffected) was 90.8% at DO completion and decreased to 69.5% at growth completion during 13 years of follow-up. Both groups showed obvious craniofacial asymmetry, as indicated by occlusal plane canting, chin deviation, transverse and vertical condyle positions, and mandibular contours. Although all the bilateral differences were higher in the NDO group than in the DO group, no statistical differences were found. Early mandible distraction could not alter the inherent facial growth pattern in patients with grade II CFM. Limited changes are derived for definitive facial correction with early DO.



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Optimizing patients undergoing surgery: Part II: Still a matter of 'eminence-based medicine'?.

No abstract available

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Septic Arthritis of the Temporomandibular Joint Secondary to Acute Otitis Media in an Adult: A Rare Case with Achromobacter xylosoxidans

Septic arthritis of the temporomandibular joint (SATMJ) is a rare complication of acute otitis media (AOM) with only four reported cases in the English and Japanese literature. Based on the unusual nature of this clinical condition, we discuss the first documented case due to Achromobacter xylosoxidans and the utility of myringotomy with long-term intravenous antibiotics via a peripherally inserted central catheter (PICC). We describe the case of a 76-year-old male patient that was brought in by ambulance to the accident and emergency (A&E) department due to severe right-sided otalgia with increased hearing impairment. A clinical diagnosis of acute otitis media with sepsis was made and the patient was commenced on the sepsis protocol. He then developed symptoms of septic arthritis of the TMJ which was confirmed on radiological imaging. After a multidisciplinary team discussion, the patient was treated with a myringotomy and intravenous ceftriaxone for 8 weeks in the community via a PICC rather than TMJ arthrocentesis with positive outcomes at 3 months' follow-up.

http://ift.tt/2nvvbWR

Does cerebellar flocculus size affect subjective outcomes in pediatric auditory brainstem implantation

Publication date: June 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 97
Author(s): Sunil Goyal, Shyam Sundaram Krishnan, Mohan Kameswaran, M.C. Vasudevan, Ranjith, Kiran Natarajan
ObjectivesThe objectives of study was to 1) Describe relevant surgical anatomy in defining and accessing the lateral recess for placement of electrode, 2) Propose a working classification for grades of Flocculus; 3) To determine if different grades of cerebellar flocculus effects placement of ABI electrode and subjective outcomes in implantees.MethodsOur study was a prospective study, and comprised of cohort of 12 patients who underwent ABI surgery via retrosigmoid approach between 1 Jan 2012 to 31 Dec 2014. All children with congenital profound sensorineural hearing loss with either absent cochlea or cochlear nerve were included in the study. Relevant anatomy was noted. We also noted down the difficulty encountered during the placement of ABI electrode. Auditory perception and speech intelligibility was scored post operatively for 1 year.ResultsCerebellar flocculus was divided into 4 grades depending on the morphology of cerebellar flocculus. It was noted that Grade 3 & 4 flocculus (Group B) had difficult ABI electrode placement in comparison to Grade 1 & 2 flocculus (Group A). The subjective outcomes of Group A was better than Group B. However the p value was not statistically significant.ConclusionCerebellar flocculus can be graded depending on morphology and size. Flocculus of higher grades can make the placement of ABI electrodes difficult and adversely effects the postoperative subjective outcomes.



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Electromyographic ratio of masseter and anterior temporalis muscles in children with and without temporomandibular disorders

Publication date: June 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 97
Author(s): Thaís Cristina Chaves, Aroldo dos Santos Aguiar, Lilian Ramiro Felicio, Stella Maris Greghi, Simone Cecilio Hallak Regalo, Débora Bevilaqua-Grossi
ObjectiveThis study investigated differences in surface electromyography (sEMG) activity of the masseter and anterior temporalis muscles in children with and without temporomandibular disorders (TMD).ParticipantsThirty-four children aged 8–12 years were recruited, comprising 17 children with TMD and 17 without TMD (control group [CG]). The children were quasi-matched for sex, age, weight, and height. sEMG data were obtained using Myosystem® Br-1 equipment with 12 channels to evaluate the bilateral masseter, anterior temporalis, and suprahyoid muscles. For sEMG analysis, raw and normalized root mean square (RMS) values were obtained at rest and during maximum clenching. The sEMG ratios of the raw RMS data of the bilateral masseter in relation to the anterior temporalis muscles (sEMG-M/AT ratio) were also assessed. Mann-Whitney tests (p ≤ 0.05) were used to compare sEMG ratio between TMD group and CG.ResultsSignificant prevalences of pain during chewing (53% vs. 0%, X2 = 5.87, p = 0.01), TMJ pain (58% vs. 0%, X2 = 6.67, p = 0.01), neck pain (58% vs. 18%, X2 = 3.77, p = 0.05) and pain in the temples (47% vs. 6%, X2 = 5.44, p = 0.02) were identified in the TMD group compared to CG. Our results revealed lower sEMG-M/AT ratios during maximum clenching (p = 0.01) in children with TMD compared to those in the asymptomatic CG.ConclusionThe results showed that children with TMD preferentially used their temporalis muscles during maximum voluntary clenching, probably as a consequence of nociceptive inputs in order to obtain pain relief.



http://ift.tt/2ndKcdB

Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit: A pilot study

Publication date: June 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 97
Author(s): Angela C. Garinis, Selena Liao, Campbell P. Cross, Johnathan Galati, Jessica L. Middaugh, Jess C. Mace, Anna-Marie Wood, Lindsey McEvoy, Lauren Moneta, Troy Lubianski, Noe Coopersmith, Nicholas Vigo, Christopher Hart, Artur Riddle, Olivia Ettinger, Casey Nold, Heather Durham, Carol MacArthur, Cynthia McEvoy, Peter S. Steyger
ObjectiveHearing loss rates in infants admitted to neonatal intensive care units (NICU) run at 2–15%, compared to 0.3% in full-term births. The etiology of this difference remains poorly understood. We examined whether the level of ambient sound and/or cumulative gentamicin (an aminoglycoside) exposure affect NICU hearing screening results, as either exposure can cause acquired, permanent hearing loss. We hypothesized that higher levels of ambient sound in the NICU, and/or gentamicin dosing, increase the risk of referral on the distortion product otoacoustic emission (DPOAE) assessments and/or automated auditory brainstem response (AABR) screens.MethodsThis was a prospective pilot outcomes study of 82 infants (<37 weeks gestational age) admitted to the NICU at Oregon Health & Science University. An ER-200D sound pressure level dosimeter was used to collect daily sound exposure in the NICU for each neonate. Gentamicin dosing was also calculated for each infant, including the total daily dose based on body mass (mg/kg/day), as well as the total number of treatment days. DPOAE and AABR assessments were conducted prior to discharge to evaluate hearing status. Exclusion criteria included congenital infections associated with hearing loss, and congenital craniofacial or otologic abnormalities.ResultsThe mean level of ambient sound was 62.9 dBA (range 51.8–70.6 dBA), greatly exceeding American Academy of Pediatrics (AAP) recommendation of <45.0 dBA. More than 80% of subjects received gentamicin treatment. The referral rate for (i) AABRs, (frequency range: ∼1000–4000 Hz), was 5%; (ii) DPOAEs with a broad F2 frequency range (2063–10031 Hz) was 39%; (iii) DPOAEs with a low-frequency F2 range (<4172 Hz) was 29%, and (iv) DPOAEs with a high-frequency F2 range (>4172 Hz) was 44%. DPOAE referrals were significantly greater for infants receiving >2 days of gentamicin dosing compared to fewer doses (p = 0.004). The effect of sound exposure and gentamicin treatment on hearing could not be determined due to the low number of NICU infants without gentamicin exposure (for control comparisons).ConclusionAll infants were exposed to higher levels of ambient sound that substantially exceed AAP guidelines. More referrals were generated by DPOAE assessments than with AABR screens, with significantly more DPOAE referrals with a high-frequency F2 range, consistent with sound- and/or gentamicin-induced cochlear dysfunction. Adding higher frequency DPOAE assessments to existing NICU hearing screening protocols could better identify infants at-risk for ototoxicity.



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Beyond Septoplasty and Turbinate Reduction: Correction of Nasal Valve Stenosis Adds Synergy to the Mix

It's not uncommon for patients to continue to have breathing problems after undergoing various procedures for obstructive sleep apnea and snoring. Among those who failed to find relief from prior surgeries, including maxillomandibular advancement (MMA), is 56-year-old Rick Smith, who underwent nasal reconstruction involving repair of a deviated septum, turbinate reduction and correction of nasal valve stenosis at Memorial Hermann-Texas Medical Center.

His surgeon was Tang Ho, MD , MSc, FACS, chief of facial plastic and reconstructive surgery in the Department of Otorhinolaryngology-Head and Neck Surgery at McGovern Medical School at UTHealth. "When we combine surgery for deviated septum and large turbinates with correction of nasal valve stenosis, there's a synergistic effect in improvement of breathing," says Dr. Ho, an assistant professor in the Department.

"Published studies have supported this, and in my practice I've found that if septoplasty and turbinate reduction provide a patient with, for example, three times the improvement, and if correction of nasal valve stenosis provides five times the improvement, the three procedures combined can produce a synergistic effect far greater than the additive benefits of these individual procedures."

After Smith moved to Houston in 1985, an annual fall visit to an ENT and a prescription for antibiotics to treat sinus infection was a given. "Then I got married in 2002, late in life, and my wife told me I snore. I had balloon sinuplasty and then the MMA surgery, but I still had sinus problems. If I lay on my side while sleeping, my sinuses would clog up and I couldn't breathe."

The reconstructive surgery Dr. Ho performed on Smith the day before Thanksgiving 2015 accounts for nearly half of his practice. "This is a condition we see frequently in our practice," he says. "The inability to breathe through the nose often goes beyond the obvious deviated septum and large turbinates to nasal valve stenosis, which is a more dynamic issue and varies depending on how forcefully you inhale. When I describe the surgery to patients, I tell them that it's essentially a cartilage repositioning procedure. We give the nose additional support, almost like an internal Breathe Right® strip that permanently opens the nasal airway."

Smith, who was prepared for swelling and a painful recovery, was pleasantly surprised. "It was basically a forgettable surgery and a very fast recovery," he says. "I had zero pain and no complications. I still have allergies so I know I'm never going to be perfect, but I can breathe freely now."



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Ishaan Pavuluri Makes a Comeback

On Easter Sunday 2016, three-year-old Ishaan Pavuluri was with his family at a pool party at the home of a friend. After an Easter egg hunt, his mother, Deepthi Bollu, was inside helping Ishaan and his older brother change into their gym shorts.

"It all happened in less than a minute," Bollu says. "While I was looking after my older son, the little one escaped, and I knew he went toward the pool. We ran outside and looked around, then ran to the front and side of the house. By then I had a bad feeling, and when we looked in the pool, we saw him at the bottom. I screamed and a gentleman jumped in and pulled him out. He had turned blue."

After nearly three minutes of CPR administered according to instructions from 911, the EMS team arrived. Ishaan was intubated in the ambulance and transported by Memorial Hermann Life Flight® to Children's Memorial Hermann Hospital in the Texas Medical Center, where he was admitted to the Pediatric Intensive Care Unit. A CT scan showed mild brain edema, and he was put on a ventilator. Two days later, when he showed improvement and responded to questions from the pediatric neurology team, his intensivist authorized removal from the ventilator and extubation.

"For the next day or so, Ishaan kept improving but toward the end of the week, he developed stridor," Bollu says. Soham Roy, MD , FACS, FAAP, professor of otorhinolaryngology director of pediatric otolaryngology at Children's Memorial Hermann Hospital, was called in to evaluate the airway.

"It's not uncommon for intubation in the field to cause trauma to the airway mucosa, especially in children," says Dr. Roy, professor and vice chair of otorhinolargyngology-head and neck surgery at McGovern Medical School at UTHealth. "When we examined him endoscopically, we found a significant subglottic injury."

The following day Dr. Roy took Ishaan to the OR, where he performed a direct laryngoscopy and bronchoscopy. A large scab in the subglottis was debrided and dilation of the airway was performed with an airway balloon. The next day, after evaluating Ishaan's progress, Dr. Roy discharged him home.

"In most cases, one endoscopic treatment will resolve the issue, but two days later Ishaan was readmitted with the same symptoms," Dr. Roy says. "We took him back to the OR and this time repeated the balloon dilation, injected a corticosteroid and postoperatively gave inhaled steroids as well. We observed him for several days and released him after a follow-up endoscopy showed he was progressing well."
"What we remember and appreciate most about Dr. Roy is his confidence," Bollu says. "We were very worried when the stridor came back after the first procedure. Dr. Roy said, 'Yes, there are airway issues, but we can handle them.' That kind of confidence gives you an immediate mental boost. It doesn't come with all doctors. First, you need good medical skills and then you need good communication skills. He told us he would take care of Ishaan, and he kept his promise. Both of the procedures were fast and clean. He knows what he's doing."

Dr. Roy says he and his team were happy they could resolve the issue with minimally invasive treatment. "It's always a great experience to treat a child who has a serious airway issue without having to place a tracheostomy or perform an extensive open airway operation," he says. "Thanks to the multidisciplinary care Ishaan received at Children's Memorial Hermann Hospital for a near-drowning event and its sequelae, he suffered no long-term injury or side effects. That's always a fine feeling."



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In vivo IL-4 prevents allo-antigen driven CD8+ CTL development

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Publication date: Available online 27 March 2017
Source:Clinical Immunology
Author(s): Charles S. Via, Kateryna Soloviova, Maksym Puliaiev, Roman Puliav, Irina Puliaeva, Suzanne C. Morris, Fred D. Finkelman
IL-4 has been shown to suppress acute graft vs. host disease (GVHD) in irradiated hosts. Here we evaluated whether IL-4 suppresses acute GVHD in the un-irradiated parent-into-F1 GVHD model with relevance to renal allograft rejection. IL-4 completely suppressed CD8 CTL when administered with donor cells however this effect was lost if its administration was delayed 3days. IL-4 did not inhibit donor CD8+ T cell homing to the host spleen but rather prevented donor CD8+ T cell differentiation into CTLs. Studies with IL-4Rα-deficient donor cells or recipient mice demonstrated that IL-4 effects on the host, rather than, or in addition to IL-4 effects on donor cells, were critical for suppression of CTL. Because IL-4 decreased all splenic dendritic cell populations and increased neutrophil and CD8+ T cells, IL-4 may suppress donor CD8+ CTL by decreasing Ag presentation and/or increasing host myeloid and CD8+ T cell suppression of donor T cells.



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Systematic analysis of splicing defects in selected primary immunodeficiencies-related genes

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Publication date: Available online 27 March 2017
Source:Clinical Immunology
Author(s): Lucie Grodecká, Pavla Hujová, Michal Kramárek, Tereza Kršjaková, Tatiana Kováčová, Katarína Vondrášková, Barbora Ravčuková, Kristýna Hrnčířová, Přemysl Souček, Tomáš Freiberger
Both variants affecting splice sites and those in splicing regulatory elements (SREs) can impair pre-mRNA splicing, eventually leading to severe diseases. Despite the availability of many prediction tools, prognosis of splicing affection is not trivial, especially when SREs are involved. Here, we present data on 92 in silico-/55 minigene-analysed variants detected in genes responsible for the primary immunodeficiencies development (namely BTK, CD40LG, IL2RG, SERPING1, STAT3, and WAS). Of 20 splicing-affecting variants, 16 affected splice site while 4 disrupted potential SRE. The presence or absence of splicing defects was confirmed in 30 of 32 blood-derived patients' RNAs. Testing prediction tools performance, splice site disruptions and creations were reliably predicted in contrast to SRE-affecting variants for which just ESRseq, ΔHZEI-scores and EX-SKIP predictions showed promising results. Next, we found an interesting pattern in cryptic splice site predictions. These results might help PID-diagnosticians and geneticists cope with potential splicing-affecting variants.



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Exposure to Mycophenolate and Fatherhood.

Background: Mycophenolic acid (MPA) is the active immunosuppressive substance in both mycophenolate mofetil and mycophenolate sodium and it is widely used after organ transplantation. In females taking MPA is teratogenic and may also influence spermatogenesis. There is a lack of knowledge regarding outcome of pregnancies fathered by males exposed to MPA. Methods: We compared outcomes in pregnancies fathered by renal transplant males per whether they had been exposed to MPA or not at time of conception. A nation-wide population-based retrospective cohort study was performed. Data from the Norwegian Renal Registry with all renal transplanted men alive between Jan. 1st 1995 and Dec. 31st 2015 were included and relevant outcome data were extracted from the Medical Birth Registry of Norway. Results: During the given time, 230 immunosuppressed renal transplanted males fathered 350 children (155 on MPA/195 not on MPA). There were no significant increased risk of malformation (3.9% vs 2.6%, P=0.49) in MPA exposed vs unexposed cohorts of children. The average dose (+/-SD) of mycophenolate was 1.42 +/- 0.3 g/day and the individual median MPA trough concentration in the time period of anticipated conception and pregnancy was 2.8 +/- 1.6 mg/L. Birth weight was similar in exposed and unexposed cohorts of children; 3381+/-681 grams vs. 3429 +/-714 grams (P=0.53). Conclusions: Paternal exposure to MPA did not increase the risk of adverse birth outcomes in children fathered by male kidney transplanted patients. These results are reassuring and support the continuation of paternal MPA treatment before, during and after conception. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.

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A Case Approach to Perioperative Drug-Drug Interactions.

No abstract available

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Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis.

Purpose of review: Animal models published within the past 18 months on asthma, food allergy and anaphylaxis, all conditions of rising public health concern, were reviewed. Recent findings: While domestic animals spontaneously develop asthma, food allergy and anaphylaxis, in animal models, divergent sensitization and challenge routes, dosages, intervals and antigens are used to induce asthmatic, food allergic or anaphylactic phenotypes. This must be considered in the interpretation of results. Instead of model antigens, gradually relevant allergens such as house dust mite in asthma, and food allergens like peanut, apple and peach in food allergy research were used. Novel engineered mouse models such as a mouse with a T-cell receptor for house dust mite allergen Der p 1, or with transgenic human hFc[gamma]R genes, facilitated the investigation of single molecules of interest. Whole-body plethysmography has become a state-of-the-art in-vivo readout in asthma research. In food allergy and anaphylaxis research, novel techniques were developed allowing real-time monitoring of in-vivo effects following allergen challenge. Networks to share tissues were established as an effort to reduce animal experiments in allergy which cannot be replaced by in-vitro measures. Summary: Natural and artificial animal models were used to explore the pathophysiology of asthma, food allergy and anaphylaxis and to improve prophylactic and therapeutic measures. Especially the novel mouse models mimicking molecular aspects of the complex immune network in asthma, food allergy and anaphylaxis will facilitate proof-of-concept studies under controlled conditions. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.

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Acute submaxillitis: Etiological data and etiological management

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Publication date: Available online 27 March 2017
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): C. Bignet, J. Carvalho, E. Lemaire, A. Charpiot
ObjectivesThe objective of the present study was to test the hypothesis that acute submaxillitis involves salivary duct obstruction. Obstacle characteristics and treatment were analyzed.Material and methodsPatients presenting with an episode of acute submaxillitis between 2009 and 2015 were retrospectively included. All underwent salivary duct imaging and/or sialendoscopy, with pathologic examination if the salivary gland was removed for etiologic diagnosis. For etiological treatment, if the causal lesion could not be treated by isolated sialendoscopy, surgery used a direct approach assisted by sialendoscope. In case of failure of these procedures, submaxillectomy was indicated.ResultsTwenty-nine patients were included, 28 of whom showed salivary duct abnormality. At least 1 calculus was found in 27 patients; calculi were usually single (n=20), situated in the mid-third (n=21), and large (mean 7.7mm). Ten patients showed stenosis, associated with salivary calculus in 9 cases. Twenty-five patients with salivary duct obstruction underwent sialendoscopy. Isolated sialendoscopy was used in 5 cases, and a combined approach in 13 cases.ConclusionAn episode of submaxillitis requires salivary duct exploration by sialendoscopy, to enable early treatment given the prevalence of associated calculi and high success rate of conservative management by sialendoscopy.



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Outpatient hemithyroidectomy: A retrospective feasibility analysis

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Publication date: Available online 27 March 2017
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): H. Yakhlef, Y. Marboeuf, A. Piquard, O. Saint Marc
BackgroundOutpatient surgery is a major public health policy issue. It is controversial for total thyroidectomy, which raises the question of hemithyroidectomy. The present study assessed our experience in outpatient hemithyroidectomy.ObjectivesTo evaluate the rates of postoperative hematoma and unscheduled hospital admission.Material and methodsA multicenter retrospective analysis was conducted in two hospital centers between January 2009 and December 2013. Exclusion criteria for outpatient hemithyroidectomy comprised: ASA score >2, anticoagulant therapy, risk of completion procedure, and associated procedure requiring >12 hours' surveillance. Data were collated for age, gender, weight, postoperative complications, and unscheduled hospital admission.ResultsDuring the study period, 294 hemithyroidectomies were performed, 130 of which on an outpatient basis (44%). There were no medical contraindications to outpatient surgery in 64% of patients operated on under conventional admission. In the outpatient group, mean age was 44 years. Eight completion thyroidectomies were performed in the outpatient group, and only two patients required admission for surveillance, with no revision surgeries. All patients were satisfied or very satisfied with outpatient management.ConclusionIn our experience, outpatient hemithyroidectomy was safe and reliable.



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Right ethmoid eosinophilic angiocentric fibrosis with orbital extension

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Publication date: Available online 27 March 2017
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): S. Gorostis, M. Bacha, S. Gravier, T. Raguin
IntroductionEosinophilic angiocentric fibrosis (EAF) is a slowly progressive, benign disease involving the mucosa of the upper airways or, more rarely, the orbit. It belongs to the spectrum of IgG4-related disease.Case reportThe authors report the case of a 61-year-old man who presented with orbital involvement (visual loss, pain, proptosis, and eyelid oedema), headache and nasal obstruction. Imaging revealed a right ethmoido-orbital mass infiltrating the periorbital fat and enveloping the optic nerve. Histological examination concluded on a diagnosis of EAF in the presence of perivascular infiltration by inflammatory cells, predominantly eosinophils, and zones of "onion skin" fibrosis. Immunohistochemistry attributed these lesions to IgG4-related disease. Initial treatment with corticosteroids followed by dapsone failed to control the disease and resulted in severe steroid dependence. Surgical ethmoidectomy with resection of the lamina papyracea was performed to allow displacement of the eyeball into the nasal cavity in the event of another episode.DiscussionThe combination of surgery and rituximab achieved lasting pain relief with no recurrence of exophthalmos.



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Hepatitis B and C Virus Infections Among Human Immunodeficiency Virus-Infected People Who Inject Drugs in Lahore, Pakistan

Viral Immunology , Vol. 0, No. 0.


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Early Immune Responses to Marek's Disease Vaccines

Viral Immunology , Vol. 0, No. 0.


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