The utility of indocyanine green near infrared fluorescent imaging in the identification of parathyroid glands during surgery for primary hyperparathyroidism
Background and Objectives Intraoperative adjuncts for the localization of parathyroid glands in parathyroid surgery are limited. The aim of this study is to assess the usefulness of indocyanine green (ICG) near-infrared (NIR) fluorescent imaging in patients undergoing surgery for primary hyperparathyroidism (PHPT). Methods ICG imaging was performed in 33 patients undergoing parathyroidectomy (PTX). Thyroid and parathyroid ICG uptake were assessed and independently verified on a grading scale. Clinical variables were recorded and analyzed for factors associated with ICG uptake. R... περισσότερα »
The feasibility of indocyanine green fluorescence imaging for identifying and assessing the perfusion of parathyroid glands during total thyroidectomy
Background There are limited adjuncts available for identifying and assessing the viability of parathyroid glands (PGs) during total thyroidectomy (TT). The aim of this study is to determine the feasibility of indocyanine green (ICG) imaging in identifying and assessing perfusion of PGs during TT. Methods ICG was administered in patients undergoing TT and fluorescence of PGs was assessed. A grading scale was developed for assessing degree of ICG uptake. Patients were evaluated for hypocalcemia and hypoparathyroidism on post-operative day (POD) #1. Results Twenty-seven patients ...περισσότερα »
The utility of indocyanine green near infrared fluorescent imaging in the identification of parathyroid glands during surgery for primary hyperparathyroidism
Background and Objectives Intraoperative adjuncts for the localization of parathyroid glands in parathyroid surgery are limited. The aim of this study is to assess the usefulness of indocyanine green (ICG) near-infrared (NIR) fluorescent imaging in patients undergoing surgery for primary hyperparathyroidism (PHPT). Methods ICG imaging was performed in 33 patients undergoing parathyroidectomy (PTX). Thyroid and parathyroid ICG uptake were assessed and independently verified on a grading scale. Clinical variables were recorded and analyzed for factors associated with ICG uptake. R... περισσότερα »
Drug Resistance via Reduced RTK Shedding [Research Articles]
Kinase inhibitor resistance often involves upregulation of poorly understood "bypass" signaling pathways. Here, we show that extracellular proteomic adaptation is one path to bypass signaling and drug resistance. Proteolytic shedding of surface receptors, which can provide negative feedback on signaling activity, is blocked by kinase inhibitor treatment and enhances bypass signaling. In particular, MEK inhibition broadly decreases shedding of multiple receptor tyrosine kinases (RTK), including HER4, MET, and most prominently AXL, an ADAM10 and ADAM17 substrate, thus increasing sur... περισσότερα »
Fish Reveal Origins of Melanoma [News in Brief]
A new study of zebrafish may explain why only certain skin cells grow into tumors. Besides melanoma-promoting mutations, these cells express key neural crest genes, such as *crestin* and *sox10*, that induce regression to an embryonic state. They also bear epigenetic changes that might amplify expression of these genes. from melanoma2 via als.fakia on Inoreader http://ift.tt/1VoI5Qs via IFTTT
Circulating Neoantigen-Specific T Cells Can Be Prospectively Identified [Immunotherapy]
PD-1 is a biomarker for circulating neoantigen-specific lymphocytes in patients with melanoma. from melanoma2 via als.fakia on Inoreader http://ift.tt/1qiynnD via IFTTT
Modified barbed soft palatal posterior pillar webbing flap palatopharyngoplasty
Abstract Background The soft palate and the lateral pharyngeal walls contribute to the collapse of the upper airway in patients with snoring and obstructive sleep apnea. In this study, the original soft palatal webbing flap palatopharyngoplasty for both soft palatal and oropharyngeal lateral wall collapse has been modified to include all tonsil grades and to apply the barbed suture technique. Methods Twenty-one adults with significant soft palatal webbing, lateral pharyngeal wall collapse, and tonsil hypertrophy of any grade were selected for the study with a minimum follow-up pe... περισσότερα »
Scaling exponent values as an ordinary function of the ratio of very low frequency to high frequency powers in heart rate variability over various sleep stages
Abstract Purpose To assess the physiological meanings of the detrended fluctuation analysis (DFA) slope α and its relationship to spectral measures in heart rate variability, this study investigated changes of α and its corresponding spectral measures over various night-sleep stages. Methods The overall DFA α and natural-logarithm-transformed power values of the spectral parameters ln[high-frequency (HF)], ln[low-frequency (LF)], and ln[very-low-frequency (VLF)], and their relationship from one 5-min proper electrocardiography segment in each of pre-sleep-wakefulness (AWK), non-r... περισσότερα »
Modified barbed soft palatal posterior pillar webbing flap palatopharyngoplasty
Abstract Background The soft palate and the lateral pharyngeal walls contribute to the collapse of the upper airway in patients with snoring and obstructive sleep apnea. In this study, the original soft palatal webbing flap palatopharyngoplasty for both soft palatal and oropharyngeal lateral wall collapse has been modified to include all tonsil grades and to… Continue reading Modified barbed soft palatal posterior pillar webbing flap palatopharyngoplasty
Scaling exponent values as an ordinary function of the ratio of very low frequency to high frequency powers in heart rate variability over various sleep stages
Abstract Purpose To assess the physiological meanings of the detrended fluctuation analysis (DFA) slope α and its relationship to spectral measures in heart rate variability, this study investigated changes of α and its corresponding spectral measures over various night-sleep stages. Methods The overall DFA α and natural-logarithm-transformed power values of the spectral parameters ln[high-frequency (HF)],… Continue reading Scaling exponent values as an ordinary function of the ratio of very low frequency to high frequency powers in heart rate variability over various sleep stages
Pancytopenia, acute renal failure and hypercalcaemia
Rare case of sarcoidosis presenting with pancytopenia, acute renal failure and hypercalcaemia: Raya Saba, Mahmoud Khreis, Frantz Francisque, Nasir Saleem<br>Mar 17, 2016; 2016:201621484-201621484<br>case-report Raya Saba, Mahmoud Khreis, Frantz Francisque, Nasir Saleem – Author Affiliations Department of Internal Medicine, Presence Saint Joseph Hospital, Chicago, Illinois, USA Correspondence to Dr Nasir Saleem, nasirsaleemmd@gmail.com Accepted 26… Continue reading Pancytopenia, acute renal failure and hypercalcaemia
Acute generalised exanthematous pustulosis due to amoxicillin-clavulanate
Acute generalised exanthematous pustulosis due to amoxicillin-clavulanate: Nuno Gaibino, Miguel Bigotte Vieira, Paulo Filipe, Anabela Oliveira<br>Mar 22, 2016; 2016:201521383-201521383<br>case-report Nuno Gaibino1, Miguel Bigotte Vieira2, Paulo Filipe3, Anabela Oliveira1 – Author Affiliations 1Internal Medicine Department, Hospital Santa Maria-Centro Hospitalar Lisboa Norte, Lisbon, Portugal 2Nephrology Department, Hospital Santa Maria-Centro Hospitalar Lisboa Norte, Lisbon, Portugal 3Clínica… Continue reading Acute generalised exanthematous pustulosis due to amoxicillin-clavula... περισσότερα »
SMC deadline is approaching
The SMC Special Session on Medical CPS is fast approaching! Make sure you do not miss the deadline. Important Dates April 15, 2016: Deadline for submission of full-length papers May 25, 2016: Acceptance/Rejection Notification. July 9, 2016: Final camera-ready papers due in electronic form. Submission Manuscripts for a Special Session should NOT be submitted in… Continue reading SMC deadline is approaching
Limbic encephalitis following immunotherapy against metastatic malignant melanoma
Limbic encephalitis following immunotherapy against metastatic malignant melanoma: Sharfaraz Salam, Timothy Lavin, Ayse Turan<br>Mar 23, 2016; 2016:201621501-201621501<br>case-report Sharfaraz Salam1,2, Timothy Lavin1, Ayse Turan1 – Author Affiliations 1Greater Manchester Neurosciences Centre, Department of Neurology, Salford Royal NHS Foundation Trust, Salford, UK 2Pennine Acute Hospitals NHS Trust, Manchester, UK Correspondence to Dr Sharfaraz Salam, sharfaraz@doctors.org.uk… Continue reading Limbic encephalitis following immunotherapy against metastatic malignant melanoma
Giant cell myocarditis: a life-threatening disorder heralded by orbital myositis
Giant cell myocarditis: a life-threatening disorder heralded by orbital myositis: Muhammad Sajawal Ali, Benjamin I Mba, Aliya Noor Husain, Farah Diba Ciftci<br>Mar 23, 2016; 2016:201521375-201521375<br>case-report Muhammad Sajawal Ali1, Benjamin I Mba1, Aliya Noor Husain2, Farah Diba Ciftci1 – Author Affiliations 1Department of Medicine, John H Stroger, Jr, Hospital of Cook County, Chicago, Illinois,… Continue reading Giant cell myocarditis: a life-threatening disorder heralded by orbital myositis
Diffuse descending necrotising mediastinitis and pleural empyema secondary to acute odontogenic infection resulting in severe dysphagia
Diffuse descending necrotising mediastinitis and pleural empyema secondary to acute odontogenic infection resulting in severe dysphagia: Peter Glen, James Morrison<br>Mar 24, 2016; 2016:201521214-201521214<br>case-report Peter Glen, James Morrison – Author Affiliations Department of Oral and Maxillofacial Surgery, St John’s Hospital, Edinburgh, UK Correspondence to Dr Peter Glen, p.glen@doctors.org.uk Summary We report a case of… Continue reading Diffuse descending necrotising mediastinitis and pleural empyema secondary to acute odontogenic infection resulting in severe dysphagia
PDL1-expression in Hodgkin- and B-cell lymphomas
Evaluation of the diagnostic and prognostic value of Activation of the programmed death 1 (PD1)/PD1 ligand (PDL1) pathway is important for tumor cells to escape from immune control. The clinical efficacy of therapeutic modulation of the PD1-PDL1 pathway has been recently shown in classical Hodgkin lymphoma (cHL), but little is known about the frequency, diagnostic… Continue reading PDL1-expression in Hodgkin- and B-cell lymphomas
Expression of OCT4 and SALL4 in Diffuse Large B-cell Lymphoma
An Analysis of 145 Consecutive Cases and Testicular Lymphomas.: OCT4 and SALL4 are transcription factors within a complex network that functions to maintain pluripotency in primitive stem cells and germ cells. Nuclear expression of OCT4 is widely cited as sensitive and specific for primary and metastatic germ cell tumors and is commonly used in the… Continue reading Expression of OCT4 and SALL4 in Diffuse Large B-cell Lymphoma
Modified barbed soft palatal posterior pillar webbing flap palatopharyngoplasty
Abstract Background The soft palate and the lateral pharyngeal walls contribute to the collapse of the upper airway in patients with snoring and obstructive sleep apnea. In this study, the original soft palatal webbing flap palatopharyngoplasty for both soft palatal and oropharyngeal lateral wall collapse has been modified to include all tonsil grades and to apply the barbed suture technique. Methods Twenty-one adults with significant soft palatal webbing, lateral pharyngeal wall collapse, and tonsil hypertrophy of any grade were selected for the study with a minimum follow-up pe... περισσότερα »
Scaling exponent values as an ordinary function of the ratio of very low frequency to high frequency powers in heart rate variability over various sleep stages
Abstract Purpose To assess the physiological meanings of the detrended fluctuation analysis (DFA) slope α and its relationship to spectral measures in heart rate variability, this study investigated changes of α and its corresponding spectral measures over various night-sleep stages. Methods The overall DFA α and natural-logarithm-transformed power values of the spectral parameters ln[high-frequency (HF)], ln[low-frequency (LF)], and ln[very-low-frequency (VLF)], and their relationship from one 5-min proper electrocardiography segment in each of pre-sleep-wakefulness (AWK), non-r... περισσότερα »
KCNQ1 mutations associated with Jervell and Lange–Nielsen syndrome and autosomal recessive Romano–Ward syndrome in India—expanding the spectrum of long QT syndrome type 1
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 11 δευτερόλεπτα
Long QT syndrome type 1 (LQT1) is the most common type of all Long QT syndromes (LQTS) and occurs due to mutations in *KCNQ1*. Biallelic mutations with deafness is called Jervell and Lange–Nielsen syndrome (JLNS) and without deafness is autosomal recessive Romano–Ward syndrome (AR RWS). In this prospective study, we report biallelic mutations in *KCNQ1* in Indian patients with LQT1 syndrome. Forty patients with a clinical diagnosis of LQT1 syndrome were referred for molecular testing. Of these, 18 were excluded from the analysis as they did not fulfill the inclusion criteria of b...περισσότερα »
Complex Camptosynpolydactyly and Mesoaxial synostotic syndactyly with phalangeal reduction are allelic disorders
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 11 δευτερόλεπτα
Complex Camptosynpolydactyly is an autosomal recessive disorder characterized by complex hand deformities described earlier by us in a consanguineous family. We report on identification of mutations in *BHLHA9* gene in this condition. Our results indicate that Complex Camptosynpolydactyly and Mesoaxial synostotic syndactyly with phalangeal reduction (MSSD) are likely to be allelic disorders. © 2016 Wiley Periodicals, Inc. from Genetics via xlomafota13 on Inoreader http://ift.tt/224BNFW via IFTTT
Carbamazepine induced Stevens-Johnson syndrome
Carbamazepine induced Stevens-Johnson syndrome: Andre B S Khoo, Faisal R Ali, Zenas Z N Yiu, Janice E Ferguson<br>Mar 11, 2016; 2016:201621492-201621492<br>case-report Andre B S Khoo1, Faisal R Ali2, Zenas Z N Yiu3, Janice E Ferguson3 - Author Affiliations 1Department of Dermatology, Norfolk & Norwich University Hospital, Norwich, UK 2St Johns Institute of Dermatology, London, UK 3Department of Dermatology, Salford Royal NHS Foundation Trust, Salford, UK Correspondence to Dr Andre Khoo, andre.khoo@cantab.net Description A 36-year-old Sri Lankan man had a 10-year his... περισσότερα »
Modified barbed soft palatal posterior pillar webbing flap palatopharyngoplasty
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Abstract Background The soft palate and the lateral pharyngeal walls contribute to the collapse of the upper airway in patients with snoring and obstructive sleep apnea. In this study, the original soft palatal webbing flap palatopharyngoplasty for both soft palatal and oropharyngeal lateral wall collapse has been modified to include all tonsil grades and to […]
Scaling exponent values as an ordinary function of the ratio of very low frequency to high frequency powers in heart rate variability over various sleep stages
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Abstract Purpose To assess the physiological meanings of the detrended fluctuation analysis (DFA) slope α and its relationship to spectral measures in heart rate variability, this study investigated changes of α and its corresponding spectral measures over various night-sleep stages. Methods The overall DFA α and natural-logarithm-transformed power values of the spectral parameters ln[high-frequency (HF)], […]
Limbic encephalitis following immunotherapy against metastatic malignant melanoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Limbic encephalitis following immunotherapy against metastatic malignant melanoma: Sharfaraz Salam, Timothy Lavin, Ayse Turan<br>Mar 23, 2016; 2016:201621501-201621501<br>case-report Sharfaraz Salam1,2, Timothy Lavin1, Ayse Turan1 – Author Affiliations 1Greater Manchester Neurosciences Centre, Department of Neurology, Salford Royal NHS Foundation Trust, Salford, UK 2Pennine Acute Hospitals NHS Trust, Manchester, UK Correspondence to Dr Sharfaraz Salam, sharfaraz@doctors.org.uk […]
Giant cell myocarditis: a life-threatening disorder heralded by orbital myositis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Giant cell myocarditis: a life-threatening disorder heralded by orbital myositis: Muhammad Sajawal Ali, Benjamin I Mba, Aliya Noor Husain, Farah Diba Ciftci<br>Mar 23, 2016; 2016:201521375-201521375<br>case-report Muhammad Sajawal Ali1, Benjamin I Mba1, Aliya Noor Husain2, Farah Diba Ciftci1 – Author Affiliations 1Department of Medicine, John H Stroger, Jr, Hospital of Cook County, Chicago, Illinois, […]
Diffuse descending necrotising mediastinitis and pleural empyema secondary to acute odontogenic infection resulting in severe dysphagia
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Diffuse descending necrotising mediastinitis and pleural empyema secondary to acute odontogenic infection resulting in severe dysphagia: Peter Glen, James Morrison<br>Mar 24, 2016; 2016:201521214-201521214<br>case-report Peter Glen, James Morrison – Author Affiliations Department of Oral and Maxillofacial Surgery, St John’s Hospital, Edinburgh, UK Correspondence to Dr Peter Glen, p.glen@doctors.org.uk Summary We report a case of […]
PDL1-expression in Hodgkin- and B-cell lymphomas
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Evaluation of the diagnostic and prognostic value of Activation of the programmed death 1 (PD1)/PD1 ligand (PDL1) pathway is important for tumor cells to escape from immune control. The clinical efficacy of therapeutic modulation of the PD1-PDL1 pathway has been recently shown in classical Hodgkin lymphoma (cHL), but little is known about the frequency, diagnostic […]
Expression of OCT4 and SALL4 in Diffuse Large B-cell Lymphoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
An Analysis of 145 Consecutive Cases and Testicular Lymphomas.: OCT4 and SALL4 are transcription factors within a complex network that functions to maintain pluripotency in primitive stem cells and germ cells. Nuclear expression of OCT4 is widely cited as sensitive and specific for primary and metastatic germ cell tumors and is commonly used in the […]
Histologic Typing in Oropharyngeal Squamous Cell Carcinoma: A 4-Year Prospective Practice Study With p16 and High-Risk HPV mRNA Testing Correlation.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Histologic Typing in Oropharyngeal Squamous Cell Carcinoma: A 4-Year Prospective Practice Study With p16 and High-Risk HPV mRNA Testing Correlation.: Oropharyngeal squamous cell carcinomas (OPSCCs) associated with human papillomavirus (HPV) represent a distinct clinical and pathologic entity. The majority of HPV-related OPSCCs have a characteristic nonkeratinizing morphology. This study sought to determine the strength of […]
The Mystery of the Thymus Gland
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
The Mystery of the Thymus Gland: Abstract The thymus is the last organ in the human body to have its mechanisms fully understood; having had its function fully delineated over fifty years ago (Miller, 2004). Prior to this, the thymus gland has had an interesting history with theories having included a role in fetal growth […]
Kounis syndrome
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Kounis syndrome From Wikipedia, the free encyclopedia Kounis syndrome is a group of symptoms that manifests as unstable vasospastic, nonvasospastic angina, or acute myocardial infarction and is triggered by the release of inflammatory mediators following anallergic insult [1]. Contents [hide] 1Definition 2Classification 3Treatment 4History 5References Definition Kounis syndrome is defined as «the concurrence of acute […]
Myocardial infarction following a bee sting
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
A case report of Kounis syndrome: Hamed Aminiahidashti, Abolghasem Laali, Abolhassan Khaje Samakoosh, Ali Morad Heidari Gorji Annals of Cardiac Anaesthesia 2016 19(2):375-378 In this case report study a 41-year-old man envenomed by a bee sting and diagnosed as Kounis syndrome secondary to hymenoptera envenomation. The patient developed a typical course of myocardial infarction, but […]
The utility of preintubation adult fiberoptic bronchoscope assessment
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
A randomized trial to assess the utility of preintubation adult fiberoptic bronchoscope assessment in patients for thoracic surgery requiring one – lung ventilation: Nayana Amin, Pritee Tarwade, Madhavi Shetmahajan, CS Pramesh, Sabita Jiwnani, Abhishek Mahajan, Nilendu Purandare Annals of Cardiac Anaesthesia 2016 19(2):251-255 Background: Confirmation of placement of Double lumen endobronchial tubes (DLETT) and bronchial […]
Pancytopenia, acute renal failure and hypercalcaemia
Rare case of sarcoidosis presenting with pancytopenia, acute renal failure and hypercalcaemia: Raya Saba, Mahmoud Khreis, Frantz Francisque, Nasir Saleem<br>Mar 17, 2016; 2016:201621484-201621484<br>case-report Raya Saba, Mahmoud Khreis, Frantz Francisque, Nasir Saleem - Author Affiliations Department of Internal Medicine, Presence Saint Joseph Hospital, Chicago, Illinois, USA Correspondence to Dr Nasir Saleem, nasirsaleemmd@gmail.com Accepted 26 February 2016 Published 17 March 2016 Description A 72-year-old Caucasian woman presented to the emergency department with ... περισσότερα »
Acute generalised exanthematous pustulosis due to amoxicillin-clavulanate
Acute generalised exanthematous pustulosis due to amoxicillin-clavulanate: Nuno Gaibino, Miguel Bigotte Vieira, Paulo Filipe, Anabela Oliveira<br>Mar 22, 2016; 2016:201521383-201521383<br>case-report Nuno Gaibino1, Miguel Bigotte Vieira2, Paulo Filipe3, Anabela Oliveira1 - Author Affiliations 1Internal Medicine Department, Hospital Santa Maria-Centro Hospitalar Lisboa Norte, Lisbon, Portugal 2Nephrology Department, Hospital Santa Maria-Centro Hospitalar Lisboa Norte, Lisbon, Portugal 3Clínica Universitária de Dermatologia, Faculdade de Medicina de Lisboa, Lisbon, Portug... περισσότερα »
Limbic encephalitis following immunotherapy against metastatic malignant melanoma
Limbic encephalitis following immunotherapy against metastatic malignant melanoma: Sharfaraz Salam, Timothy Lavin, Ayse Turan<br>Mar 23, 2016; 2016:201621501-201621501<br>case-report Sharfaraz Salam1,2, Timothy Lavin1, Ayse Turan1 - Author Affiliations 1Greater Manchester Neurosciences Centre, Department of Neurology, Salford Royal NHS Foundation Trust, Salford, UK 2Pennine Acute Hospitals NHS Trust, Manchester, UK Correspondence to Dr Sharfaraz Salam, sharfaraz@doctors.org.uk Accepted 9 March 2016 Published 23 March 2016 Summary Novel immunotherapies are increasingl... περισσότερα »
Giant cell myocarditis: a life-threatening disorder heralded by orbital myositis
Giant cell myocarditis: a life-threatening disorder heralded by orbital myositis: Muhammad Sajawal Ali, Benjamin I Mba, Aliya Noor Husain, Farah Diba Ciftci<br>Mar 23, 2016; 2016:201521375-201521375<br>case-report Muhammad Sajawal Ali1, Benjamin I Mba1, Aliya Noor Husain2, Farah Diba Ciftci1 - Author Affiliations 1Department of Medicine, John H Stroger, Jr, Hospital of Cook County, Chicago, Illinois, USA 2Department of Pathology, University of Chicago, Chicago, USA Correspondence to Dr Muhammad Sajawal Ali, sajawalhotiana@gmail.com Summary A 40-year-old man with a his...περισσότερα »
Diffuse descending necrotising mediastinitis and pleural empyema secondary to acute odontogenic infection resulting in severe dysphagia
Diffuse descending necrotising mediastinitis and pleural empyema secondary to acute odontogenic infection resulting in severe dysphagia: Peter Glen, James Morrison<br>Mar 24, 2016; 2016:201521214-201521214<br>case-report Peter Glen, James Morrison - Author Affiliations Department of Oral and Maxillofacial Surgery, St John's Hospital, Edinburgh, UK Correspondence to Dr Peter Glen, p.glen@doctors.org.uk Summary We report a case of acute odontogenic sepsis in a 59-year-old man, presenting with diffuse, descending necrotising mediastinitis complicated by pleural empyema. Desp...περισσότερα »
Modified barbed soft palatal posterior pillar webbing flap palatopharyngoplasty
Abstract Background The soft palate and the lateral pharyngeal walls contribute to the collapse of the upper airway in patients with snoring and obstructive sleep apnea. In this study, the original soft palatal webbing flap palatopharyngoplasty for both soft palatal and oropharyngeal lateral wall collapse has been modified to include all tonsil grades and to apply the barbed suture technique. Methods Twenty-one adults with significant soft palatal webbing, lateral pharyngeal wall collapse, and tonsil hypertrophy of any grade were selected for the study with a minimum follow-up pe... περισσότερα »
Scaling exponent values as an ordinary function of the ratio of very low frequency to high frequency powers in heart rate variability over various sleep stages
Abstract Purpose To assess the physiological meanings of the detrended fluctuation analysis (DFA) slope α and its relationship to spectral measures in heart rate variability, this study investigated changes of α and its corresponding spectral measures over various night-sleep stages. Methods The overall DFA α and natural-logarithm-transformed power values of the spectral parameters ln[high-frequency (HF)], ln[low-frequency (LF)], and ln[very-low-frequency (VLF)], and their relationship from one 5-min proper electrocardiography segment in each of pre-sleep-wakefulness (AWK), non-r... περισσότερα »
Dentin abrasivity of various desensitizing toothpastes
The aim of this study was to compare the abrasivity of various commercially available toothpastes that claim to reduce dentin hypersensitivity. from #ENT via xlomafota13 on Inoreader http://ift.tt/1XaNeLa via IFTTT
PDL1-expression in Hodgkin- and B-cell lymphomas
Evaluation of the diagnostic and prognostic value of Activation of the programmed death 1 (PD1)/PD1 ligand (PDL1) pathway is important for tumor cells to escape from immune control. The clinical efficacy of therapeutic modulation of the PD1-PDL1 pathway has been recently shown in classical Hodgkin lymphoma (cHL), but little is known about the frequency, diagnostic and prognostic importance of PDL1 expression in lymphomas. The available anti-PDL1 antibody clones E1L3N and SP142 were compared and a large cohort of HL (n=280) and B-cell lymphomas (n=619) was examined for PDL1 using E1L...περισσότερα »
Expression of OCT4 and SALL4 in Diffuse Large B-cell Lymphoma
An Analysis of 145 Consecutive Cases and Testicular Lymphomas.: [image: wk-health-logo.gif] OCT4 and SALL4 are transcription factors within a complex network that functions to maintain pluripotency in primitive stem cells and germ cells. Nuclear expression of OCT4 is widely cited as sensitive and specific for primary and metastatic germ cell tumors and is commonly used in the diagnosis of central nervous system (CNS) germinomas. Studies have failed to systematically examine the expression of OCT4 or SALL4 in diffuse large B-cell lymphoma (DLBCL), although this entity enters the mor... περισσότερα »
Histologic Typing in Oropharyngeal Squamous Cell Carcinoma: A 4-Year Prospective Practice Study With p16 and High-Risk HPV mRNA Testing Correlation.
Histologic Typing in Oropharyngeal Squamous Cell Carcinoma: A 4-Year Prospective Practice Study With p16 and High-Risk HPV mRNA Testing Correlation.: [image: wk-health-logo.gif] Oropharyngeal squamous cell carcinomas (OPSCCs) associated with human papillomavirus (HPV) represent a distinct clinical and pathologic entity. The majority of HPV-related OPSCCs have a characteristic nonkeratinizing morphology. This study sought to determine the strength of the association between nonkeratinizing histology and HPV status compared with other squamous cell carcinoma variants in 4 years of r... περισσότερα »
The Mystery of the Thymus Gland
The Mystery of the Thymus Gland: Abstract The thymus is the last organ in the human body to have its mechanisms fully understood; having had its function fully delineated over fifty years ago (Miller, 2004). Prior to this, the thymus gland has had an interesting history with theories having included a role in fetal growth and development before becoming more sinisterly, a cause of sudden infant death in the late 19th century known as *status lymphaticus* (Paltauf, 1889). Until Miller (1961) eventually proved its primarily immunological role, the history of this mysterious gland has... περισσότερα »
Kounis syndrome
Kounis syndrome *From Wikipedia, the free encyclopedia* *Kounis syndrome is a group of symptoms that manifests as unstable vasospastic, nonvasospastic angina, or acute myocardial infarction and is triggered by the release of inflammatory mediators following anallergic insult [1].* Contents* [hide] * - *1Definition* - *2Classification* - *3Treatment* - *4History* - *5References* Definition *Kounis syndrome is defined as "the concurrence of acute coronary syndromes with conditions associated with mast cell activation, involving interrelated and interacting inflammatory ... περισσότερα »
Myocardial infarction following a bee sting
A case report of Kounis syndrome: *Hamed Aminiahidashti, Abolghasem Laali, Abolhassan Khaje Samakoosh, Ali Morad Heidari Gorji* Annals of Cardiac Anaesthesia 2016 19(2):375-378 In this case report study a 41-year-old man envenomed by a bee sting and diagnosed as Kounis syndrome secondary to hymenoptera envenomation. The patient developed a typical course of myocardial infarction, but the electrocardiogram changes were reversed to almost normal limits. He had a nonsignificant mild lesion in the proximal port of right coronary artery in coronary angiography. The case recovered and...περισσότερα »
The utility of preintubation adult fiberoptic bronchoscope assessment
A randomized trial to assess the utility of preintubation adult fiberoptic bronchoscope assessment in patients for thoracic surgery requiring one - lung ventilation: *Nayana Amin, Pritee Tarwade, Madhavi Shetmahajan, CS Pramesh, Sabita Jiwnani, Abhishek Mahajan, Nilendu Purandare* Annals of Cardiac Anaesthesia 2016 19(2):251-255 Background: Confirmation of placement of Double lumen endobronchial tubes (DLETT) and bronchial blockers (BBs) with the pediatric fiberoptic bronchoscope (FOB) is the most preferred practice worldwide. Most centers possess standard adult FOBs, some, part...περισσότερα »
Black or white coffee before anaesthesia?
Gastric volume measured by MRI: A randomised crossover trial.: BACKGROUND: In current preoperative fasting guidelines, coffee with milk is still regarded by many as solid food. Evidence on the consequences for gastric volume of adding milk to coffee 2 h before anaesthesia is still weak. OBJECTIVES: The aim of this study was to compare the gastric volume by MRI in healthy volunteers after drinking coffee with and without added milk. DESIGN: A randomised crossover trial where all participants were exposed to three coffee and milk mixtures performed as a noninferiority study with a pr... περισσότερα »
Intraoperative and Postoperative Administration of Dexmedetomidine Reduces Anesthetic and Postoperative Analgesic Requirements in Patients Undergoing Cervical Spine Surgeries.
Intraoperative and Postoperative Administration of Dexmedetomidine Reduces Anesthetic and Postoperative Analgesic Requirements in Patients Undergoing Cervical Spine Surgeries.: Background: Early recovery from anesthesia and avoidance of analgesics with respiratory depressant properties are vital for maintenance of extubated airway in cervical spine surgeries. The current study investigated the role of dexmedetomidine as an anesthetic sparing agent and as a sole postoperative analgesic in these cases. Materials and Methods: Sixty adult patients undergoing cervical spine surgeries wer...περισσότερα »
Acute Epidural Hematoma Formation in Cervical Spine After Interlaminar Epidural Steroid Injection Despite Discontinuation of Clopidogrel.
Acute Epidural Hematoma Formation in Cervical Spine After Interlaminar Epidural Steroid Injection Despite Discontinuation of Clopidogrel.: Background: Perioperative management of patients on anticoagulant therapy prior to interventional pain procedures creates a challenge when balancing the risk of bleeding against thromboembolic events. Case Report: We report a case of epidural hematoma formation in the cervical spine following interlaminar epidural steroid injection in an elderly woman with chronic neck and arm pain, who was on clopidogrel therapy. Conclusions: This is the first ... περισσότερα »
Anatomic Basis for Brachial Plexus Block at the Costoclavicular Space: A Cadaver Anatomic Study.
Anatomic Basis for Brachial Plexus Block at the Costoclavicular Space: A Cadaver Anatomic Study.: Background and Objectives: The costoclavicular space (CCS), which is located deep and posterior to the midpoint of the clavicle, may be a better site for infraclavicular brachial plexus block than the traditional lateral paracoracoid site. However, currently, there is paucity of data on the anatomy of the brachial plexus at the CCS. We undertook this cadaver anatomic study to define the anatomy of the cords of the brachial plexus at the CCS and thereby establish the anatomic basis for u... περισσότερα »
Accurate needle control during ultrasound (US)-guided nerve blocks
Evaluation of a New Needle Guidance System for Ultrasound: Results of a Prospective, Randomized, Blinded Study.: Background and Objectives: Accurate needle control during ultrasound (US)-guided nerve blocks may be an elusive goal for the anesthesiologist. Despite modifications to increase echogenicity, needle visibility still requires precise alignment within the transducer beam. In this study, we evaluated a magnetically guided ultrasound (MGU) system that produces a real-time, graphic display of the needle position and trajectory that is independent of the US beam. Methods: The MG... περισσότερα »
Dentin abrasivity of various desensitizing toothpastes
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
The aim of this study was to compare the abrasivity of various commercially available toothpastes that claim to reduce dentin hypersensitivity. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XaNeLa via IFTTT
Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Publication date: Available online 3 April 2016 Source:Journal of Biomechanics Author(s): Mojtaba Azadi, Hadi Tavakoli Nia, Stephanie J. Gauci, Christine Ortiz, Amanda J. Fosang, Alan J. Grodzinsky Aggrecan loss in human and animal cartilage precedes clinical symptoms of osteoarthritis, suggesting that aggrecan loss is an initiating step in cartilage pathology. Characterizing early stages of cartilage […]
Asian Journal of Management Cases
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Asian Journal of Management Cases, published by SAGE Publications, last updated on 2016-04-01, available at http://ajc.sagepub.com from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ajc.sagepub.com/ via IFTTT
Drug Resistance via Reduced RTK Shedding [Research Articles]
Kinase inhibitor resistance often involves upregulation of poorly understood "bypass" signaling pathways. Here, we show that extracellular proteomic adaptation is one path to bypass signaling and drug resistance. Proteolytic shedding of surface receptors, which can provide negative feedback on signaling activity, is blocked by kinase inhibitor treatment and enhances bypass signaling. In particular, MEK inhibition broadly decreases shedding of multiple receptor tyrosine kinases (RTK), including HER4, MET, and most prominently AXL, an ADAM10 and ADAM17 substrate, thus increasing sur... περισσότερα »
Fish Reveal Origins of Melanoma [News in Brief]
A new study of zebrafish may explain why only certain skin cells grow into tumors. Besides melanoma-promoting mutations, these cells express key neural crest genes, such as *crestin* and *sox10*, that induce regression to an embryonic state. They also bear epigenetic changes that might amplify expression of these genes. from melanoma2 via als.fakia on Inoreader http://ift.tt/1VoI5Qs via IFTTT
Circulating Neoantigen-Specific T Cells Can Be Prospectively Identified [Immunotherapy]
PD-1 is a biomarker for circulating neoantigen-specific lymphocytes in patients with melanoma. from melanoma2 via als.fakia on Inoreader http://ift.tt/1qiynnD via IFTTT
Drug Resistance via Reduced RTK Shedding [Research Articles]
Kinase inhibitor resistance often involves upregulation of poorly understood "bypass" signaling pathways. Here, we show that extracellular proteomic adaptation is one path to bypass signaling and drug resistance. Proteolytic shedding of surface receptors, which can provide negative feedback on signaling activity, is blocked by kinase inhibitor treatment and enhances bypass signaling. In particular, MEK inhibition broadly decreases shedding of multiple receptor tyrosine kinases (RTK), including HER4, MET, and most prominently AXL, an ADAM10 and ADAM17 substrate, thus increasing sur... περισσότερα »
Fish Reveal Origins of Melanoma [News in Brief]
A new study of zebrafish may explain why only certain skin cells grow into tumors. Besides melanoma-promoting mutations, these cells express key neural crest genes, such as *crestin* and *sox10*, that induce regression to an embryonic state. They also bear epigenetic changes that might amplify expression of these genes. from melanoma2 via als.fakia on Inoreader http://ift.tt/1VoI5Qs via IFTTT
Circulating Neoantigen-Specific T Cells Can Be Prospectively Identified [Immunotherapy]
PD-1 is a biomarker for circulating neoantigen-specific lymphocytes in patients with melanoma. from melanoma2 via als.fakia on Inoreader http://ift.tt/1qiynnD via IFTTT
Association of trihalomethanes in tap water with house dust mite allergen sensitization
in US adolescents via Allergy and Clinical Immunology *Source:*Journal of Allergy and Clinical Immunology Author(s): Jin-Young Min, Yong-Seok Seo, Hyun-Jin Kim, Kyoung-Bok Min
Sensitization of a child to Cyanobacteria after recreational swimming in a lake
Sensitization of a child to Cyanobacteria after recreational swimming in a lake via Allergy and Clinical Immunology Publication date: Available online 31 March 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Esmond N. Geh, Armah A. de la Cruz, Debajyoti Ghosh, Gerard Stelma, Jonathan A. Bernstein Figures and tables 1. [image: Facial rash with periorbital edema (A) and erythematous blistering rash on the ...] 2. [image: A, IgE-specific ELISA with extracts from various Cyanobacteria species: (1) ...] 3. [image: A, Microphotographs of axenic cultures... περισσότερα »
The autoinflammatory Schnitzler syndrome
Dysregulation of proinflammatory versus anti-inflammatory human TH17 cell functionalities in via Allergy and Clinical Immunology Publication date: Available online 31 March 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Rebecca Noster, Heleen D. de Koning, Elisabeth Maier, Martina Prelog, Elke Lainka, Christina E. Zielinski BackgroundTH17 cells have so far been considered to be crucial mediators of autoimmune inflammation. Two distinct types of TH17 cells have been described recently, which differed in their polarization requirement for IL-1β and in their cytokine... περισσότερα »
Omalizumab for the treatment of chronic spontaneous urticaria
: A meta-analysis of randomized clinical trials via Allergy and Clinical Immunology Publication date: Available online 31 March 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Zuo-Tao Zhao, Chun-Mei Ji, Wen-Jun Yu, Ling Meng, Tomasz Hawro, Ji-Fu Wei, Marcus Maurer BackgroundChronic spontaneous urticaria (CSU) is defined by itchy hives, angioedema, or both for at least 6 weeks. Omalizumab, an anti-IgE antibody that affects mast cell and basophil function, is a promising new treatment option. As of now, however, the efficacy and safety of different doses of omalizumab...περισσότερα »
GA²LEN, the Global Allergy and Asthma European Network : Definition, aims, and implementation of GA²LEN Urticaria Centers of Reference and Excellence
Definition, aims, and implementation of GA²LEN Urticaria Centers of Reference and Excellence: Abstract GA²LEN, the Global Allergy and Asthma European Network, has recently launched a programme for the development, interaction and accreditation of centers of reference and excellence in special areas of allergy embedded in its overall quality management of allergy centres of excellence. The first area chosen is urticaria. Urticaria is a common and debilitating condition and can be a challenge for both patients and treating physicians, especially when chronic. Centers of reference and... περισσότερα »
Ramadan fasting period
The impact of “Ramadan fasting period” on total and differential white blood cells, haematological indices, inflammatory biomarker, respiratory symptoms and pulmonary function tests of healthy and asthmatic patients via Allergologia et Immunopathologia Publication date: Available online 31 March 2016 *Source:*Allergologia et Immunopathologia Author(s): V.R. Askari, A. Alavinezhad, M.H. Boskabady BackgroundThere is no conclusive evidence regarding the effect of fasting on different features in asthmatic patients. In the present study, the effect of Ramadan fasting in asthmatic patients a...περισσότερα »
The Angioedema Quality of Life Questionnaire (AE-QoL)
Assessment of Sensitivity to Change and Minimal Clinically Important Difference: Abstract Background The Angioedema Quality of Life Questionnaire (AE-QoL) has recently been developed and validated as the first specific patient reported outcome tool to assess quality of life (QoL) impairment in recurrent angioedema patients. As of yet, its sensitivity to change and minimal clinically important difference (MCID) have not been established. Methods Recurrent angioedema patients with chronic spontaneous urticaria or hereditary angioedema were repeatedly asked to complete the AE-QoL along...περισσότερα »
Streptococcus mitis and Gemella haemolysans were simultaneously found in atherosclerotic and oral plaques of elderly without periodontitis—a pilot study
—a pilot study: Abstract Objectives Local infections may contribute to the initiation and progression of several clinical diseases in humans. Atherosclerotic plaques of subjects suffering from periodontitis are colonized by periopathogens; however, the presence of bacteria in atherosclerotic plaques in patients without severe forms of periodontitis is of high relevance for the general population. Materials… Continue reading Streptococcus mitis and Gemella haemolysans were simultaneously found in atherosclerotic and oral plaques of elderly without periodontitis—a pilot study
Location of the extraosseous and intraosseous arterial anastomosis of the maxillary sinus in edentulous specimens
Location of the extraosseous and intraosseous arterial anastomosis of the maxillary sinus in edentulous specimens: Abstract Objectives The aim of this anatomical study was to measure the distance from the intraosseous and extraosseous arterial anastomoses of the maxillary sinus to the alveolar ridge in edentulous specimens dissected from human cadavers. Materials and methods Forty edentulous… Continue reading Location of the extraosseous and intraosseous arterial anastomosis of the maxillary sinus in edentulous specimens
Cranio-maxillofacial reconstruction with microvascular radialis flaps
—parameters and correlations of postoperative pain management: Abstract Objectives Postoperative pain management is of highest interest for patients undergoing maxillofacial surgery including microvascular reconstructive surgery. Currently, there is a lack of information regarding process and outcome of postoperative pain management after microvascular reconstruction. Materials and methods In a prospective clinical study, 31 adults were evaluated… Continue reading Cranio-maxillofacial reconstruction with microvascular radialis flaps
Mucosal and salivary microbiota associated with recurrent aphthous stomatitis.
Mucosal and salivary microbiota associated with recurrent aphthous stomatitis.: BMC Microbiol. 2016;16(1):57 Authors: Kim YJ, Choi YS, Baek KJ, Yoon SH, Park HK, Choi Y Abstract BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder of unclear etiopathogenesis. Although recent studies of the oral microbiota by high-throughput sequencing of 16S rRNA genes have… Continue reading Mucosal and salivary microbiota associated with recurrent aphthous stomatitis.
Desensitizing toothpastes
Dentin abrasivity of various desensitizing toothpastes: Abstract Background The aim of this study was to compare the abrasivity of various commercially available toothpastes that claim to reduce dentin hypersensitivity. Methods Dentin discs were prepared from 70 human extracted molars. The discs were etched with lemon juice for 5 min, and one half of the discs… Continue reading Desensitizing toothpastes
OR Management of Recurrent Respiratory Papilloma
OR Management of Recurrent Respiratory Papilloma: Abstract Surgical management of recurrent respiratory papillomatosis has depended upon surgical removal and debulking of disease to maintain a patent airway and preserve vocal function. Over time, this has evolved from cold instrumentation alone to microscope-guided laser ablation. Powered instrumentation in the form of microdebriders has also come to… Continue reading OR Management of Recurrent Respiratory Papilloma
Gelastic Migraine and Other Unusual Headache Syndromes
No Laughing Matter Abstract Primary and secondary headache disorders have established diagnostic criteria in the International Classification of Headache Disorders IIIb, as well as classic findings, which although not part of the formal criteria are often suggestive of a particular diagnosis. At times, headache disorders can involve unusual symptoms that lack an identifiable secondary cause.… Continue reading Gelastic Migraine and Other Unusual Headache Syndromes
Alternative Therapies for Chronic Pain Syndromes
Role of Abstract There is increasing interest in the use of complimentary and alternative medicine (CAM) for the treatment of chronic pain. This review examines alternative and complimentary therapies, which can be incorporated as part of a biopsychosocial approach in the treatment of chronic pain syndromes. In the present investigation, literature from articles indexed on… Continue reading Alternative Therapies for Chronic Pain Syndromes
New Chronic Pain Treatments
in the Outpatient Setting: Review Article: Abstract Chronic pain is an issue encountered by many health care providers in their routine clinical practice. In addition to generalized patient suffering, this condition has significant clinical, psychological, and socioeconomic impact due to its widespread occurrence. The landscape of chronic pain management has been changing rapidly with an… Continue reading New Chronic Pain Treatments
Infantile Colic and Migraine
The Link Between Infantile Colic and Migraine: Abstract Infantile colic is a self-limiting disorder of excessive infant crying or fussiness that peaks at 6 weeks of age and typically improves by 3 months of age. The etiology of infantile colic has yet to be definitively elucidated, but there is increasing research to support its relationship… Continue reading Infantile Colic and Migraine
25(OH)D3 and 1,25(OH)2D3 on Th17 cell differentiation
Comparative effect of via Clinical Immunology Publication date: Available online 1 April 2016 *Source:*Clinical Immunology Author(s): Lama Fawaz, May F. Mrad, Jalal M. Kazan, Souraya Sayegh, Reem Akika, Samia J. Khoury Vitamin D is a secosteroid hormone that plays an important regulatory role in calcium homeostasis and bone metabolism. Immune cells can both produce and respond to 1,25(OH)2D3. CD4+ T cells from vitamin D receptor (VDR) KO mice produce higher levels of IFN-γ and IL-17 than their wild type counterparts, and play a crucial role in the pathogenesis of autoimmune diseases ...περισσότερα »
Asthmatic patients with influenza-like illness and risk of severe exacerbations
Clinical characteristics of asthmatic patients with influenza-like illness and risk of severe exacerbations in Mexico via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online 1 April 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Paulina Paulin-Prado, Katherine Nishimura, Laura Freimanis-Hance, Sally Hunsberger, John Beigel, Arturo Galindo Fraga, Ana A. Ortiz Hernandez, Beatriz Llamosas-Gallardo, Sarbelio Moreno-Espinosa, Martin Magaña-Aquino, Guillermo M. Ruiz Palacios, Alejandra Ramirez-Venegas BackgroundPatients with ch... περισσότερα »
Self-reported prevalence and risk factors associated with food hypersensitivity
in Mexican young adults via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online 1 April 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Cecilia Puente-Fernández, Rosalba L. Maya-Hernández, Miriam V. Flores-Merino, María del Socorro Romero-Figueroa, Martín Bedolla-Barajas, Ma. Victoria Domínguez García BackgroundFood hypersensitivity (FH) is defined as any unfavorable reaction after the ingestion, contact, or inhalation of a food. Few FH prevalence studies have been performed in the Mexican adult population.ObjectivesTo d... περισσότερα »
The Australasian Society of Clinical Immunology and Allergy (ASCIA) News
ASCIA News: ASCIA News - Updated Infant Feeding Advice and Guidelines for Allergy Prevention in Infants Mar 14, 2016: The Australasian Society of Clinical Immunology and Allergy (ASCIA), the peak body for allergy and critical immunology in Australia, has updated the infant feeding advice and guidelines for allergy prevention in infants. "Allergic disorders are often life long, and although treatable, there is currently no cure. It t... - Adrenaline autoinjector expiry da... περισσότερα »
Intranasal triamcinolone use during pregnancy and the risk of adverse pregnancy outcomes
Intranasal triamcinolone use during pregnancy and the risk of adverse pregnancy outcomes via Allergy and Clinical Immunology Publication date: Available online 1 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Anick Bérard, Odile Sheehy, Marie-Laure Kurzinger, Juhaeri Juhaeri BackgroundIntranasal corticosteroid use during pregnancy has increased over the past decade.ObjectiveWe aim to estimate the safety of intranasal triamcinolone use during pregnancy, which was introduced for over-the-counter use in October 2013.MethodsWe designed a population-based prospec... περισσότερα »
Light emitting diode mediated photobiomodulation therapy improves orthodontic tooth movement and miniscrew stability: A randomized controlled clinical trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
Background and Objectives The aim of this study was to evaluate the effects of light-emitting diode-mediated-photobiomodulation therapy (LPT) on the stability of miniscrews, rate of orthodontic tooth movement, and interleukin-1β levels in gingival and peri-implant crevicular fluid. Materials and Methods This study was a double blind, randomized placebo/control matched pairs clinical trial to test the […]
Dentin abrasivity of various desensitizing toothpastes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
The aim of this study was to compare the abrasivity of various commercially available toothpastes that claim to reduce dentin hypersensitivity. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1XaNeLa via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Cytometry by time-of-flight immunophenotyping identifies a blood Sjögren's signature
Cytometry by time-of-flight immunophenotyping identifies a blood Sjögren's signature correlating with disease activity and glandular inflammation via Allergy and Clinical Immunology Publication date: Available online 1 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Michael Mingueneau, Saida Boudaoud, Scott Haskett, Taylor L. Reynolds, Gaetane Nocturne, Elizabeth Norton, Xueli Zhang, Myrtha Constant, Daniel Park, Wenting Wang, Thierry Lazure, Christine Le Pajolec, Ayla Ergun, Xavier Mariette BackgroundMass cytometry has recently emerged as a promising tool for ... περισσότερα »
Cesarean section and immune-mediated disease
Cesarean section changes neonatal gut colonization via Allergy and Clinical Immunology Publication date: Available online 1 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Jakob Stokholm, Jonathan Thorsen, Bo L. Chawes, Susanne Schjørring, Karen A. Krogfelt, Klaus Bønnelykke, Hans Bisgaard BackgroundDelivery by means of cesarean section has been associated with increased risk of childhood immune-mediated diseases, suggesting a role of early bacterial colonization patterns for immune maturation.ObjectiveWe sought to describe the influence of delivery method on g... περισσότερα »
Reconstruction of the tongue and mouth floor with the myofascial vastus lateralis free flap
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
after cancer ablation via Oral and Maxillofacial Surgery Publication date: Available online 3 April 2016 Source:International Journal of Oral and Maxillofacial Surgery Author(s): L. Wang, K. Liu, Z. Shao, Z.-J. Shang The current study was undertaken to evaluate a novel approach to tongue and mouth floor reconstruction using the myofascial vastus lateralis free flap (MVLF). […]
Molecular Markers of Fibro-Osseous Lesions and Osteosarcomas of the Craniofacial Complex—Current Situation and Recent Advances
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
Molecular Markers of Fibro-Osseous Lesions and Osteosarcomas of the Craniofacial Complex—Current Situation and Recent Advances: Abstract Fibro-osseous lesions share clinical, radiological, and pathological features, particularly in the craniofacial complex, a location where diagnosing these lesions is challenging. Some molecular markers involved in the pathogenesis of these lesions offer significant diagnostic support. Guanine nucleotide-binding protein/alpha subunit […]
Benign Paroxysmal Positional Vertigo Following Sinus Floor Elevation in Patient with Antecedents of Vertigo
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
Benign Paroxysmal Positional Vertigo Following Sinus Floor Elevation in Patient with Antecedents of Vertigo: Abstract Benign paroxysmal positional vertigo (BPPV) is an unfamiliar and rare complication occurring following osteotome sinus floor elevation (OSFE) and simultaneous implant placement. Etiology of this disorder is commonly displacement of otoliths by vibratory forces transmitted by osteotomes and mallet along […]
Compression Dressing Using Dental Impression Compound for Conservative Management of Sialocele
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
Compression Dressing Using Dental Impression Compound for Conservative Management of Sialocele: Abstract A Sialocele or salivary pseudocyst is due to extravasation of saliva into periglandular tissue due to disruption of gland parenchyma. Various techniques of management have been described in literature; both conservative and surgical management have been documented. We report a simple economical and […]
Streptococcus mitis and Gemella haemolysans were simultaneously found in atherosclerotic and oral plaques of elderly without periodontitis—a pilot study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
—a pilot study: Abstract Objectives Local infections may contribute to the initiation and progression of several clinical diseases in humans. Atherosclerotic plaques of subjects suffering from periodontitis are colonized by periopathogens; however, the presence of bacteria in atherosclerotic plaques in patients without severe forms of periodontitis is of high relevance for the general population. Materials […]
Location of the extraosseous and intraosseous arterial anastomosis of the maxillary sinus in edentulous specimens
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
Location of the extraosseous and intraosseous arterial anastomosis of the maxillary sinus in edentulous specimens: Abstract Objectives The aim of this anatomical study was to measure the distance from the intraosseous and extraosseous arterial anastomoses of the maxillary sinus to the alveolar ridge in edentulous specimens dissected from human cadavers. Materials and methods Forty edentulous […]
Cranio-maxillofacial reconstruction with microvascular radialis flaps
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
—parameters and correlations of postoperative pain management: Abstract Objectives Postoperative pain management is of highest interest for patients undergoing maxillofacial surgery including microvascular reconstructive surgery. Currently, there is a lack of information regarding process and outcome of postoperative pain management after microvascular reconstruction. Materials and methods In a prospective clinical study, 31 adults were evaluated […]
Mucosal and salivary microbiota associated with recurrent aphthous stomatitis.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
Mucosal and salivary microbiota associated with recurrent aphthous stomatitis.: BMC Microbiol. 2016;16(1):57 Authors: Kim YJ, Choi YS, Baek KJ, Yoon SH, Park HK, Choi Y Abstract BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder of unclear etiopathogenesis. Although recent studies of the oral microbiota by high-throughput sequencing of 16S rRNA genes have […]
Desensitizing toothpastes
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
Dentin abrasivity of various desensitizing toothpastes: Abstract Background The aim of this study was to compare the abrasivity of various commercially available toothpastes that claim to reduce dentin hypersensitivity. Methods Dentin discs were prepared from 70 human extracted molars. The discs were etched with lemon juice for 5 min, and one half of the discs […]
OR Management of Recurrent Respiratory Papilloma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
OR Management of Recurrent Respiratory Papilloma: Abstract Surgical management of recurrent respiratory papillomatosis has depended upon surgical removal and debulking of disease to maintain a patent airway and preserve vocal function. Over time, this has evolved from cold instrumentation alone to microscope-guided laser ablation. Powered instrumentation in the form of microdebriders has also come to […]
Protective effects of intranasal curcumin on Ovalbumin-induced allergic inflammation
Ovalbumin-induced allergic inflammation lead to structural alterations in mouse model and protective effects of intranasal curcumin: A comparative study via Allergologia et Immunopathologia Publication date: Available online 1 April 2016 *Source:*Allergologia et Immunopathologia Author(s): Subhashini, P.S. Chauhan, R. Singh BackgroundAntigen exposure and persistent inflammation leads to structural changes in the asthmatic airways which are collectively termed as “airway remodelling”. Presently available asthma medications ameliorate inflammations but are unable to prevent or reverse th...περισσότερα »
Annals of Allergy, Asthma & Immunology
Xq22.1 contiguous gene deletion syndrome of X-linked agammaglobulinemia and Mohr-Tranebjærg syndrome We report a case of an uncommon contiguous gene syndrome involving deletion of genetic material from chromosome Xq22.1. Informed consent was obtained from the patient for the reporting of this case. Our patient is a 27-year-old man with X-linked agammaglobulinemia (XLA) first diagnosed when he presented at 11 months of age in the summer of 1989 with acute-onset bilateral flaccid paralysis and sensory loss in his lower extremities subsequent to varicella infection 4 weeks before that ...περισσότερα »
Current Allergy and Asthma Reports
Epigenetic Dysfunction in Turner Syndrome Immune Cells Abstract Turner syndrome (TS) is a chromosomal condition associated with partial or complete absence of the X chromosome that involves characteristic findings in multiple organ systems. In addition to well-known clinical characteristics such as short stature and gonadal failure, TS is also associated with T cell immune alterations and chronic otitis media, suggestive of a possible immune deficiency. Recently, ubiquitously transcribed tetratricopeptide repeat on the X chromosome (UTX), a histone H3 lysine 27 (H3K27) demethylase, ...περισσότερα »
Mutant KRAS Copy-Number Gain Drives Metabolic Reprogramming Metabolism
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Homozygous and heterozygous KRAS mutant cancer cells have distinct metabolic phenotypes. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1XaKr4D via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Molecular Mechanism of Mutant CALR-Mediated Transformation In the Spotlight
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Summary: Elf and colleagues used an elegant series of functional and biochemical assays to investigate the molecular mechanism of mutant calreticulin (CALR)–driven cellular transformation in myeloproliferative neoplasms (MPN). Mutant CALR is sufficient to induce MPN in mouse transplantation experiments, and transformation is dependent upon physical interaction mediated by the positive electrostatic charge of the mutant […]
Accelerating Lead Compound Optimization News in Brief
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Chemists at The Scripps Research Institute in La Jolla, CA, and Pfizer’s La Jolla Laboratories have devised a new way to rapidly synthesize strained-ring structures, which are increasingly favored to optimize potential drugs. With this method, strain-release amination, Pfizer researchers were able to produce sufficient quantities of a particular structure they needed to evaluate a […]
Targeting p300 Addiction in CBP-Deficient Cancers Research Articles
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Loss-of-function mutations in the CBP/CREBBP gene, which encodes a histone acetyltransferase (HAT), are present in a variety of human tumors, including lung, bladder, gastric, and hematopoietic cancers. Consequently, development of a molecular targeting method capable of specifically killing CBP-deficient cancer cells would greatly improve cancer therapy. Functional screening of synthetic-lethal genes in CBP-deficient cancers identified […]
NUDT15 Variants Alter Thiopurine-Associated Hematopoietic Toxicity Drug Response
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Inactivating NUDT15 polymorphisms are associated with thiopurine intolerance. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiynnH via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Exercise Reduces Tumor Initiation and Progression in Mouse Models Tumorigenesis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Running suppresses tumor growth in mouse tumor models by increasing natural killer cell infiltration. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1XaKr4v via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Metastatic Prostate Tumors Exhibit Limited Intraindividual Heterogeneity Genomics
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Metastatic prostate tumors exhibit high heterogeneity among and not within individuals. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiylw5 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Rps14 Haploinsufficiency Promotes Erythroid Differentiation Defects Myelodysplastic Syndrome
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Rps14 haploinsufficiency promotes an S100A8-mediated p53-dependent erythroid differentiation block. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiARCC via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Dentin abrasivity of various desensitizing toothpastes
The aim of this study was to compare the abrasivity of various commercially available toothpastes that claim to reduce dentin hypersensitivity. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1XaNeLa via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Reconstruction of the tongue and mouth floor with the myofascial vastus lateralis free flap
after cancer ablation via Oral and Maxillofacial Surgery Publication date: Available online 3 April 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): L. Wang, K. Liu, Z. Shao, Z.-J. Shang The current study was undertaken to evaluate a novel approach to tongue and mouth floor reconstruction using the myofascial vastus lateralis free flap (MVLF). The surgical techniques, benefits, complication rate, and the aesthetic and functional results are described. A series of six patients underwent functional tongue reconstruction between July 2013 and November 2014... περισσότερα »
Molecular Markers of Fibro-Osseous Lesions and Osteosarcomas of the Craniofacial Complex—Current Situation and Recent Advances
Molecular Markers of Fibro-Osseous Lesions and Osteosarcomas of the Craniofacial Complex—Current Situation and Recent Advances: AbstractFibro-osseous lesions share clinical, radiological, and pathological features, particularly in the craniofacial complex, a location where diagnosing these lesions is challenging. Some molecular markers involved in the pathogenesis of these lesions offer significant diagnostic support. *Guanine nucleotide-binding protein/alpha subunit* (*GNAS*) mutations are specific to fibrous dysplasias and are not encountered in ossifying fibromas (including juve...περισσότερα »
Benign Paroxysmal Positional Vertigo Following Sinus Floor Elevation in Patient with Antecedents of Vertigo
Benign Paroxysmal Positional Vertigo Following Sinus Floor Elevation in Patient with Antecedents of Vertigo: AbstractBenign paroxysmal positional vertigo (BPPV) is an unfamiliar and rare complication occurring following osteotome sinus floor elevation (OSFE) and simultaneous implant placement. Etiology of this disorder is commonly displacement of otoliths by vibratory forces transmitted by osteotomes and mallet along with the hyperextension of the head during the operation, causing them to float around in the endolymph. This report presents a case of protracted BPPV following OSFE ... περισσότερα »
Compression Dressing Using Dental Impression Compound for Conservative Management of Sialocele
Compression Dressing Using Dental Impression Compound for Conservative Management of Sialocele: AbstractA Sialocele or salivary pseudocyst is due to extravasation of saliva into periglandular tissue due to disruption of gland parenchyma. Various techniques of management have been described in literature; both conservative and surgical management have been documented. We report a simple economical and efficient method to deal with sailocele presenting after neck dissection.
Streptococcus mitis and Gemella haemolysans were simultaneously found in atherosclerotic and oral plaques of elderly without periodontitis—a pilot study
—a pilot study: Abstract ObjectivesLocal infections may contribute to the initiation and progression of several clinical diseases in humans. Atherosclerotic plaques of subjects suffering from periodontitis are colonized by periopathogens; however, the presence of bacteria in atherosclerotic plaques in patients without severe forms of periodontitis is of high relevance for the general population. Materials and methodsPatients who were electively treated for atherosclerotic lesions of the carotid artery and without clinical signs of periodontitis were eligible for the study. Oral... περισσότερα »
Location of the extraosseous and intraosseous arterial anastomosis of the maxillary sinus in edentulous specimens
Location of the extraosseous and intraosseous arterial anastomosis of the maxillary sinus in edentulous specimens: Abstract ObjectivesThe aim of this anatomical study was to measure the distance from the intraosseous and extraosseous arterial anastomoses of the maxillary sinus to the alveolar ridge in edentulous specimens dissected from human cadavers. Materials and methodsForty edentulous maxillary specimens were dissected, anatomically prepared, and injected for a better visualization of the maxillary sinus artery. ResultsThis study showed that the mean distance from the ... περισσότερα »
Dentin abrasivity of various desensitizing toothpastes
The aim of this study was to compare the abrasivity of various commercially available toothpastes that claim to reduce dentin hypersensitivity. from #ENT via xlomafota13 on Inoreader http://ift.tt/1XaNeLa via IFTTT
Cranio-maxillofacial reconstruction with microvascular radialis flaps
—parameters and correlations of postoperative pain management: Abstract ObjectivesPostoperative pain management is of highest interest for patients undergoing maxillofacial surgery including microvascular reconstructive surgery. Currently, there is a lack of information regarding process and outcome of postoperative pain management after microvascular reconstruction. Materials and methodsIn a prospective clinical study, 31 adults were evaluated on the first postoperative day following microvascular reconstruction with a radial forearm flap using the standardized questionnaire o... περισσότερα »
Mucosal and salivary microbiota associated with recurrent aphthous stomatitis.
Mucosal and salivary microbiota associated with recurrent aphthous stomatitis.: BMC Microbiol. 2016;16(1):57 Authors: Kim YJ, Choi YS, Baek KJ, Yoon SH, Park HK, Choi Y Abstract BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder of unclear etiopathogenesis. Although recent studies of the oral microbiota by high-throughput sequencing of 16S rRNA genes have suggested that imbalances in the oral microbiota may contribute to the etiopathogenesis of RAS, no specific bacterial species associated with RAS have been identified. The present study aimed to cha... περισσότερα »
Desensitizing toothpastes
Dentin abrasivity of various desensitizing toothpastes: Abstract BackgroundThe aim of this study was to compare the abrasivity of various commercially available toothpastes that claim to reduce dentin hypersensitivity. MethodsDentin discs were prepared from 70 human extracted molars. The discs were etched with lemon juice for 5 min, and one half of the discs were covered with aluminum tape. Following this, they were brushed with 6 different toothpastes, simulating a total brushing time of 6 months. As a negative control, discs were brushed with tap water only. The toothpastes ... περισσότερα »
OR Management of Recurrent Respiratory Papilloma
OR Management of Recurrent Respiratory Papilloma: AbstractSurgical management of recurrent respiratory papillomatosis has depended upon surgical removal and debulking of disease to maintain a patent airway and preserve vocal function. Over time, this has evolved from cold instrumentation alone to microscope-guided laser ablation. Powered instrumentation in the form of microdebriders has also come to serve an important role for the rapid removal of exophytic, airway obstructive disease. With this evolving technologic sophistication, the surgical paradigm has progressed from maintain... περισσότερα »
Gelastic Migraine and Other Unusual Headache Syndromes
No Laughing Matter AbstractPrimary and secondary headache disorders have established diagnostic criteria in the International Classification of Headache Disorders IIIb, as well as classic findings, which although not part of the formal criteria are often suggestive of a particular diagnosis. At times, headache disorders can involve unusual symptoms that lack an identifiable secondary cause. This review will discuss some of these unusual symptoms, including headache associated auditory and olfactory symptoms, as well as two case reports involving gelastic migraine and migrainous thor... περισσότερα »
Alternative Therapies for Chronic Pain Syndromes
Role of AbstractThere is increasing interest in the use of complimentary and alternative medicine (CAM) for the treatment of chronic pain. This review examines alternative and complimentary therapies, which can be incorporated as part of a biopsychosocial approach in the treatment of chronic pain syndromes. In the present investigation, literature from articles indexed on PubMed was evaluated including topics of alternative therapies, complimentary therapies, pain psychology, biofeedback therapy, physical exercise therapies, acupuncture, natural and herbal supplements, whole-body ...περισσότερα »
New Chronic Pain Treatments
in the Outpatient Setting: Review Article: AbstractChronic pain is an issue encountered by many health care providers in their routine clinical practice. In addition to generalized patient suffering, this condition has significant clinical, psychological, and socioeconomic impact due to its widespread occurrence. The landscape of chronic pain management has been changing rapidly with an array of treatment innovations, better understanding of established therapies, and care coordination across specialties. In this article, we have reviewed emerging new modalities as well as transfo... περισσότερα »
Infantile Colic and Migraine
The Link Between Infantile Colic and Migraine: AbstractInfantile colic is a self-limiting disorder of excessive infant crying or fussiness that peaks at 6 weeks of age and typically improves by 3 months of age. The etiology of infantile colic has yet to be definitively elucidated, but there is increasing research to support its relationship to migraine. The aims of this review are to present recent research investigating the connection between infantile colic and migraine. The importance of identifying this connection is useful in reducing invasive and potentially harmful investiga... περισσότερα »
Ice Pick Headache
Ice Pick Headache: AbstractIce pick headache, also called idiopathic or primary stabbing headache, is a unique headache type associated with ultra-brief stabs of pain, most commonly in the frontal or temporal area. It occurs predominantly in women and is estimated to affect 2–35 % of the population. Unlike other headache types of short duration, such as short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT), ice pick headache is not associated with any cranial autonomic symptoms but has been known to occur with nausea, vomiting, photophobia, ...περισσότερα »
Effect of lifestyle modifications on oxidative stress in elderly essential hypertensive patients
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
2016-04-03T21-16-35Z *Source:* International Journal of Medical Science and Public Health Anubhav Bhatnagar, Usha Dhar, Yogesh Tripathi. Background: Cardiovascular disease (CVD) is one of the leading causes of morbidity and mortality in elderly people, while essential hypertension is a major risk factor for CVD. However, extensive experimental data support a role for increased reactive oxygen species levels and altered redox signaling in the pathogenesis of hypertension. Objective: This study evaluates the effects of lifestyle modifications on oxidative stress and blood pressure in ... περισσότερα »
Effects of breast cancer related lymphedema on hand muscle strength, hand functions and sensory loss of hand
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
2016-04-03T19-51-08Z *Source:* Cukurova Medical Journal Gül Mete Civelek. Objective: In this study, we aimed to investigate clinical features of patients with breast cancer related lymphedema (BCRL) and effects of BCRL on hand muscle strength and function. Materials and Methods: Patients applying to oncologic rehabilitation polyclinic with right hand dominancy were included in the study. Clinical and demographic data of all patients were noted, physical examinations were performed. The presence of shoulder pain was questioned. To determine the hand grip strength Jamar hand dynamome...περισσότερα »
Antibiotic Resistance of Streptococcus pneumoniae and Haemophilus influenzae Isolated from Respiratory Tract Specimens
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
2016-04-03T19-51-08Z *Source:* Cukurova Medical Journal Hikmet Eda Alışkan, Şule Çolakoğlu, Jülide Sedef Göçmen. Streptococcus pneumoniae and Haemophilus influenzae are two of the major pathogens in respiratory infections, treatment is usually started empirically. However, in recent years these two bacterial species are becoming increasingly resistant to a variety of antibiotics. The aim of this study was to detect in vitro resistance rates of S. pneumoniae and H. influenzae strains isolated from different lower respiratory clinical samples to the antibotics which are used for thera... περισσότερα »
Mutant KRAS Copy-Number Gain Drives Metabolic Reprogramming Metabolism
Homozygous and heterozygous KRAS mutant cancer cells have distinct metabolic phenotypes. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1XaKr4D via IFTTT
Noted News in Brief
A collection of recently published news items. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiAQ1e via IFTTT
Tracking Tumor Evolution through Mathematics News in Brief
A recent study suggests that many cancers undergo neutral evolution, with all key mutations present at the start of malignancy. New mutations acquired along the way don’t confer any advantages on tumor cells. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiym37 via IFTTT
Mutant CALR Requires Its C-terminus and MPL to Transform Research Articles
Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative neoplasms (MPN), but the mechanism by which mutant CALR is oncogenic remains unclear. Here, we demonstrate that expression of mutant CALR alone is sufficient to engender MPN in mice and recapitulates the disease phenotype of patients with CALR-mutant MPN. We further… Continue reading Mutant CALR Requires Its C-terminus and MPL to Transform Research Articles
Illumina Spin-off to Develop Early-Detection Test News in Brief
DNA-sequencing giant Illumina has formed a new company, called Grail, to develop liquid biopsies capable of spotting cancer before symptoms arise. The start-up is working on a low-cost «pan-cancer» test that can detect multiple cancer types early, which it hopes to introduce by 2019. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiym33 via IFTTT
TGF{beta} Mediates Tumor Suppression via Induction of EMT-Linked Apoptosis Pancreatic Cancer
TGFβ induces a SMAD4-dependent EMT in the pancreas that promotes apoptosis. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiART0 via IFTTT
Expanding the Scope of ENCODE News in Brief
The National Human Genome Research Institute has earmarked up to $38 million in grant funding for five new initiatives aimed at expanding ENCODE, its database of functional elements in human and mouse genomes. For the first time, grantees will focus on diseased tissue samples in an effort to understand how these functional elements influence the… Continue reading Expanding the Scope of ENCODE News in Brief
Molecular Mechanism of Mutant CALR-Mediated Transformation In the Spotlight
Summary: Elf and colleagues used an elegant series of functional and biochemical assays to investigate the molecular mechanism of mutant calreticulin (CALR)–driven cellular transformation in myeloproliferative neoplasms (MPN). Mutant CALR is sufficient to induce MPN in mouse transplantation experiments, and transformation is dependent upon physical interaction mediated by the positive electrostatic charge of the mutant… Continue reading Molecular Mechanism of Mutant CALR-Mediated Transformation In the Spotlight
Accelerating Lead Compound Optimization News in Brief
Chemists at The Scripps Research Institute in La Jolla, CA, and Pfizer’s La Jolla Laboratories have devised a new way to rapidly synthesize strained-ring structures, which are increasingly favored to optimize potential drugs. With this method, strain-release amination, Pfizer researchers were able to produce sufficient quantities of a particular structure they needed to evaluate a… Continue reading Accelerating Lead Compound Optimization News in Brief
Targeting p300 Addiction in CBP-Deficient Cancers Research Articles
Loss-of-function mutations in the CBP/CREBBP gene, which encodes a histone acetyltransferase (HAT), are present in a variety of human tumors, including lung, bladder, gastric, and hematopoietic cancers. Consequently, development of a molecular targeting method capable of specifically killing CBP-deficient cancer cells would greatly improve cancer therapy. Functional screening of synthetic-lethal genes in CBP-deficient cancers identified… Continue reading Targeting p300 Addiction in CBP-Deficient Cancers Research Articles
NUDT15 Variants Alter Thiopurine-Associated Hematopoietic Toxicity Drug Response
Inactivating NUDT15 polymorphisms are associated with thiopurine intolerance. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiynnH via IFTTT
Exercise Reduces Tumor Initiation and Progression in Mouse Models Tumorigenesis
Running suppresses tumor growth in mouse tumor models by increasing natural killer cell infiltration. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1XaKr4v via IFTTT
Metastatic Prostate Tumors Exhibit Limited Intraindividual Heterogeneity Genomics
Metastatic prostate tumors exhibit high heterogeneity among and not within individuals. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiylw5 via IFTTT
Rps14 Haploinsufficiency Promotes Erythroid Differentiation Defects Myelodysplastic Syndrome
Rps14 haploinsufficiency promotes an S100A8-mediated p53-dependent erythroid differentiation block. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiARCC via IFTTT
Circulating Neoantigen-Specific T Cells Can Be Prospectively Identified Immunotherapy
PD-1 is a biomarker for circulating neoantigen-specific lymphocytes in patients with melanoma. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiynnD via IFTTT
Plasmacytoid Variant Bladder Cancers Harbor CDH1 Mutations Bladder Cancer
CDH1 mutations are specific to, and occur in the majority of, plasmacytoid variant bladder cancers. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1XaKsFM via IFTTT
Inhibition of p38 or MK2 Increases SMAC-Mimetic Efficacy against AML Leukemia
The loss of p38 or MK2 enhances SMAC-mimetic–mediated TNF production and cytotoxicity. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiynnw via IFTTT
Lifting Up the HAT: Synthetic Lethal Screening Reveals a Novel Vulnerability at the CBP-p300 Axis In the Spotlight
Summary: Cancer genotype–specific synthetic lethal vulnerabilities represent promising therapeutic targets. In this issue of Cancer Discovery, Ogiwara and colleagues uncover a synthetic lethal relationship between two histone acetyl transferase paralogs, CBP and p300, highlighting that cancer cells deficient in CBP are uniquely sensitized to genetic and chemical inhibition of p300. Cancer Discov; 6(4); 350–2. ©2016… Continue reading Lifting Up the HAT: Synthetic Lethal Screening Reveals a Novel Vulnerability at the CBP-p300 Axis In the Spotlight
Dual Therapy with DDR1 and Notch Inhibitors Kills KRAS-Mutant Lung Tumors Lung Cancer
Combined DDR1 and Notch inhibition is as effective as chemotherapy in KRAS-mutant lung adenocarcinoma. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiylvW via IFTTT
Circulating Neoantigen-Specific T Cells Can Be Prospectively Identified Immunotherapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
PD-1 is a biomarker for circulating neoantigen-specific lymphocytes in patients with melanoma. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiynnD via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Plasmacytoid Variant Bladder Cancers Harbor CDH1 Mutations Bladder Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
CDH1 mutations are specific to, and occur in the majority of, plasmacytoid variant bladder cancers. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1XaKsFM via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Inhibition of p38 or MK2 Increases SMAC-Mimetic Efficacy against AML Leukemia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The loss of p38 or MK2 enhances SMAC-mimetic–mediated TNF production and cytotoxicity. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiynnw via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Lifting Up the HAT: Synthetic Lethal Screening Reveals a Novel Vulnerability at the CBP-p300 Axis In the Spotlight
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary: Cancer genotype–specific synthetic lethal vulnerabilities represent promising therapeutic targets. In this issue of Cancer Discovery, Ogiwara and colleagues uncover a synthetic lethal relationship between two histone acetyl transferase paralogs, CBP and p300, highlighting that cancer cells deficient in CBP are uniquely sensitized to genetic and chemical inhibition of p300. Cancer Discov; 6(4); 350–2. ©2016 […]
Dual Therapy with DDR1 and Notch Inhibitors Kills KRAS-Mutant Lung Tumors Lung Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Combined DDR1 and Notch inhibition is as effective as chemotherapy in KRAS-mutant lung adenocarcinoma. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qiylvW via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Monocytes Regulate Fibrosis in Pancreatic Carcinoma Research Articles
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Dense fibrosis and a robust macrophage infiltrate are key therapeutic barriers in pancreatic ductal adenocarcinoma (PDAC). CD40 activation can circumvent these barriers by inducing macrophages, originating from peripheral blood monocytes, to deplete fibrosis. The precise mechanism and therapeutic implications of this antifibrotic activity, though, remain unclear. Here, we report that IFN and CCL2 released systemically […]
Transclival injury after routine transnasal rhinological surgery
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: June 2016 Source:Clinical Neurology and Neurosurgery, Volume 145 Author(s): Shadi Al-Afif, Makoto Nakamura, Thomas Lenarz, Joachim K. Krauss ObjectivesRoutine transnasal rhinological procedures are widely practiced and are considered as safe, in general. Skull base lesions occur in less than 1% of procedures and typically involve the anterior or middle cranial fossa, while clivus […]
Familial incidence of the congenital torcular dural arteriovenous shunt: Case report and review of the literature
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: May 2016 Source:Clinical Neurology and Neurosurgery, Volume 144 Author(s): Amir R. Honarmand, Michael C. Hurley, Sameer A. Ansari, Tord D. Alden, Ryan Kuhn, Furqan H. Syed, Ali Shaibani Congenital dural sinus malformations are rare but can be major causes of mortality and morbidity in the pediatric population if not detected and managed urgently. […]
HOPE-3: Does Primary Cardiovascular Prevention Benefit People at Intermediate Risk? (FREE)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
By the NEJM Journal Watch Editors Findings from the HOPE-3 trial provide some answers — and perhaps raise more questions — on the use of statins and antihypertensives in patients at intermediate risk for cardiovascular (CV) disease. The findings were published in the New England Journal of Medicine and presented at the American College of […]
FDA Moves to Limit Inorganic Arsenic in Infant Rice Cereal (FREE)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
By Amy Orciari Herman Edited by Susan Sadoughi, MD, and André Sofair, MD, MPH The FDA proposed on Friday a limit for inorganic arsenic in infant rice cereal, citing epidemiologic evidence that exposure to … from Uncategorized via xlomafota13 on Inoreader http://ift.tt/1ZXXNCX via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader […]
No more pain upon Gq-protein-coupled receptor activation: role of endocannabinoids
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The above article from European Journal of Neuroscience, published online on 4 February 2014 in Wiley Online Library (http://ift.tt/1TuP6PK), has been retracted by agreement between the Editors-in-Chief, Paul Bolam and John Foxe, the authors and John Wiley & Sons Ltd. The retraction has been agreed as the above article has been found to overlap substantially […]
Your NEJM Group Today: Opioid Misuse Review, Anti-HCV Regimens in Elders, Boston-Area Dermatology Opportunity (FREE)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
By the Editors NEJM Group offers so many valuable resources for practicing clinicians. Here’s what we chose for you today: NEJM Clinical Practice Center: … from Uncategorized via xlomafota13 on Inoreader http://ift.tt/1ZXXN5U via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UCuS7P via IFTTT
A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The above article from European Journal of Neuroscience, published online on 5 March 2013 in Wiley Online Library (http://ift.tt/1TuP6zj), has been retracted by agreement between the Editors-in-Chief, Paul Bolam and John Foxe, the authors and John Wiley & Sons Ltd. The retraction has been agreed as Dr Phillip Barber has informed the publisher that he […]
FDA: Presence of Electronic Medical Devices Should Not Preclude CT Scans (FREE)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
By Amy Orciari Herman Edited by Susan Sadoughi, MD, and André Sofair, MD, MPH The presence of insulin pumps, pacemakers, implantable cardioverter defibrillators, and neurostimulators should not prevent use of medically indicated computed tomographic scans, the FDA has advised. While … from Uncategorized via xlomafota13 on Inoreader http://ift.tt/1Vot6Gl via IFTTT from #Med Blogs by Alexandros […]
Ebola Death in Liberia, Guinea Trying Experimental Vaccine (FREE)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
By the Editors A 30-year-old woman in Liberia died from Ebola late last week. It’s the third time the virus has resurfaced there since … from Uncategorized via xlomafota13 on Inoreader http://ift.tt/1RTymzo via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UCuTbR via IFTTT
Issue Cover (April 2016)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Cover image by Daniel J. Hegeman, Ellie S. Hong, Vivian M. Hernández and C. Savio Chan from Neurology via xlomafota13 on Inoreader http://ift.tt/1TuP6z9 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1pYJXDA via IFTTT
Transclival injury after routine transnasal rhinological surgery
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: June 2016 Source:Clinical Neurology and Neurosurgery, Volume 145 Author(s): Shadi Al-Afif, Makoto Nakamura, Thomas Lenarz, Joachim K. Krauss ObjectivesRoutine transnasal rhinological procedures are widely practiced and are considered as safe, in general. Skull base lesions occur in less than 1% of procedures and typically involve the anterior or middle cranial fossa, while clivus […]
From the Blogs: Fun with Academic Spam, Negotiating Your Contract (FREE)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
By the Editors Take a look at what the NEJM Journal Watch bloggers are talking about right now: HIV … from Uncategorized via xlomafota13 on Inoreader http://ift.tt/1ZXXNmi via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1S12W7a via IFTTT
Bipolar disorder
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Bipolar disorder: A mood disorder sometimes called manic-depressive illness or manic-depression that characteristically involves cycles of depression and elation or mania. Sometimes the mood switches from high to low and back again are dramatic and rapid, but more often they are gradual and slow, and intervals of normal mood may occur between the high (manic) […]
Variable levels of apoptotic signal-associated cytokines in the disease course of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background/Objectives Keratinocyte death is a hallmark of Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). Apoptotic signal-associated cytokines, such as TNF-α, sFasL, granulysin, sTRAIL and IFN-γ have been reported to participate in keratinocyte apoptosis. However, their levels are variable, which hampers the elucidation of the role of these cytokines. We sought to determine whether cytokine […]
Variable levels of apoptotic signal-associated cytokines in the disease course of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis
Abstract Background/Objectives Keratinocyte death is a hallmark of Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). Apoptotic signal-associated cytokines, such as TNF-α, sFasL, granulysin, sTRAIL and IFN-γ have been reported to participate in keratinocyte apoptosis. However, their levels are variable, which hampers the elucidation of the role of these cytokines. We sought to determine whether cytokine levels vary with disease course. Methods The serum cytokine levels of 24 patients and blister fluid of 10 were analysed by enzyme-linked immunosorbent assay on the...περισσότερα »
No more pain upon Gq-protein-coupled receptor activation: role of endocannabinoids
The above article from European Journal of Neuroscience, published online on 4 February 2014 in Wiley Online Library (http://ift.tt/1TuP6PK), has been retracted by agreement between the Editors-in-Chief, Paul Bolam and John Foxe, the authors and John Wiley & Sons Ltd. The retraction has been agreed as the above article has been found to overlap substantially with the article 'Chiou, L.-C., Hu, S. S.-J., and Ho, Y.-C. (2013), Targeting the cannabinoid system for pain relief? Acta Anaesthesiologica Taiwanica, Volume 51, Issue 4: 161 – 170. doi: 10.1016/j.aat.2013.10.004', which was ... περισσότερα »
A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia
The above article from European Journal of Neuroscience, published online on 5 March 2013 in Wiley Online Library (http://ift.tt/1TuP6zj), has been retracted by agreement between the Editors-in-Chief, Paul Bolam and John Foxe, the authors and John Wiley & Sons Ltd. The retraction has been agreed as Dr Phillip Barber has informed the publisher that he had seen neither the original data nor any version of the manuscript, and had not been involved in the work reported. A subsequent Institutional investigation found evidence of misconduct on the part of the submitting author. *Refere...περισσότερα »
Issue Cover (April 2016)
[image: Thumbnail image of graphical abstract] Cover image by Daniel J. Hegeman, Ellie S. Hong, Vivian M. Hernández and C. Savio Chan from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1TuP6z9 via IFTTT
No more pain upon Gq-protein-coupled receptor activation: role of endocannabinoids
The above article from European Journal of Neuroscience, published online on 4 February 2014 in Wiley Online Library (http://ift.tt/1TuP6PK), has been retracted by agreement between the Editors-in-Chief, Paul Bolam and John Foxe, the authors and John Wiley & Sons Ltd. The retraction has been agreed as the above article has been found to overlap substantially with the article 'Chiou, L.-C., Hu, S. S.-J., and Ho, Y.-C. (2013), Targeting the cannabinoid system for pain relief? Acta Anaesthesiologica Taiwanica, Volume 51, Issue 4: 161 – 170. doi: 10.1016/j.aat.2013.10.004', which was ... περισσότερα »
A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia
The above article from European Journal of Neuroscience, published online on 5 March 2013 in Wiley Online Library (http://ift.tt/1TuP6zj), has been retracted by agreement between the Editors-in-Chief, Paul Bolam and John Foxe, the authors and John Wiley & Sons Ltd. The retraction has been agreed as Dr Phillip Barber has informed the publisher that he had seen neither the original data nor any version of the manuscript, and had not been involved in the work reported. A subsequent Institutional investigation found evidence of misconduct on the part of the submitting author. *Refere...περισσότερα »
Issue Cover (April 2016)
[image: Thumbnail image of graphical abstract] Cover image by Daniel J. Hegeman, Ellie S. Hong, Vivian M. Hernández and C. Savio Chan from Neurology via xlomafota13 on Inoreader http://ift.tt/1TuP6z9 via IFTTT
Transclival injury after routine transnasal rhinological surgery
[image: alertIcon.gif] Publication date: June 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 145 Author(s): Shadi Al-Afif, Makoto Nakamura, Thomas Lenarz, Joachim K. Krauss ObjectivesRoutine transnasal rhinological procedures are widely practiced and are considered as safe, in general. Skull base lesions occur in less than 1% of procedures and typically involve the anterior or middle cranial fossa, while clivus lesions have not been well documented. Here we present a series of three patients with iatrogenic transclival lesions after routine transnasal rhinological procedur... περισσότερα »
Familial incidence of the congenital torcular dural arteriovenous shunt: Case report and review of the literature
[image: alertIcon.gif] Publication date: May 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 144 Author(s): Amir R. Honarmand, Michael C. Hurley, Sameer A. Ansari, Tord D. Alden, Ryan Kuhn, Furqan H. Syed, Ali Shaibani Congenital dural sinus malformations are rare but can be major causes of mortality and morbidity in the pediatric population if not detected and managed urgently. Lesions involving large draining sinus structures such as superior sagittal sinus and torcular herophili can result in significant intracranial circulation impairment mostly due to venous drainage ... περισσότερα »
Issue Information
from Neurology via xlomafota13 on Inoreader http://ift.tt/1Y9O4Id via IFTTT
Experimental neurotransplantation treatment for hereditary cerebellar ataxias
Abstract Hereditary cerebellar degenerations are a heterogeneous group of diseases often having a detrimental impact on patients' quality of life. Unfortunately, no sufficiently effective causal therapy is available for human patients at present. There are several therapies that have been shown to affect the pathogenetic process and thereby to delay the progress of the disease in mouse models of cerebellar ataxias. The second experimental therapeutic approach for hereditary cerebellar ataxias is neurotransplantation. Grafted cells might provide an effect via delivery of a scarce n... περισσότερα »
Transclival injury after routine transnasal rhinological surgery
Publication date: June 2016 Source:Clinical Neurology and Neurosurgery, Volume 145 Author(s): Shadi Al-Afif, Makoto Nakamura, Thomas Lenarz, Joachim K. Krauss ObjectivesRoutine transnasal rhinological procedures are widely practiced and are considered as safe, in general. Skull base lesions occur in less than 1% of procedures and typically involve the anterior or middle cranial fossa, while clivus… Continue reading Transclival injury after routine transnasal rhinological surgery
Familial incidence of the congenital torcular dural arteriovenous shunt: Case report and review of the literature
Publication date: May 2016 Source:Clinical Neurology and Neurosurgery, Volume 144 Author(s): Amir R. Honarmand, Michael C. Hurley, Sameer A. Ansari, Tord D. Alden, Ryan Kuhn, Furqan H. Syed, Ali Shaibani Congenital dural sinus malformations are rare but can be major causes of mortality and morbidity in the pediatric population if not detected and managed urgently.… Continue reading Familial incidence of the congenital torcular dural arteriovenous shunt: Case report and review of the literature
Bipolar disorder
Bipolar disorder: A mood disorder sometimes called manic-depressive illness or manic-depression that characteristically involves cycles of depression and elation or mania. Sometimes the mood switches from high to low and back again are dramatic and rapid, but more often they are gradual and slow, and intervals of normal mood may occur between the high (manic)… Continue reading Bipolar disorder
Analysis of observed surface ozone in the dry season over Eastern Thailand during 1997–2012
Publication date: 1 September 2016 Source:Atmospheric Research, Volumes 178–179 Author(s): Nosha Assareh, Thayukorn Prabamroong, Kasemsan Manomaiphiboon, Phunsak Theramongkol, Sirakarn Leungsakul, Nawarat Mitrjit, Jintarat Rachiwong This study analyzed observed surface ozone (O3) in the dry season over a long-term period of 1997–2012 for the eastern region of Thailand and incorporated several technical tools or methods in… Continue reading Analysis of observed surface ozone in the dry season over Eastern Thailand during 1997–2012
Effect of lifestyle modifications on oxidative stress in elderly essential hypertensive patients
2016-04-03T21-16-35Z Source: International Journal of Medical Science and Public Health Anubhav Bhatnagar, Usha Dhar, Yogesh Tripathi. Background: Cardiovascular disease (CVD) is one of the leading causes of morbidity and mortality in elderly people, while essential hypertension is a major risk factor for CVD. However, extensive experimental data support a role for increased reactive oxygen species… Continue reading Effect of lifestyle modifications on oxidative stress in elderly essential hypertensive patients
A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia
The above article from European Journal of Neuroscience, published online on 5 March 2013 in Wiley Online Library (http://ift.tt/1TuP6zj), has been retracted by agreement between the Editors-in-Chief, Paul Bolam and John Foxe, the authors and John Wiley & Sons Ltd. The retraction has been agreed as Dr Phillip Barber has informed the publisher that he… Continue reading A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia
Variable levels of apoptotic signal-associated cytokines in the disease course of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis
Abstract Background/Objectives Keratinocyte death is a hallmark of Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). Apoptotic signal-associated cytokines, such as TNF-α, sFasL, granulysin, sTRAIL and IFN-γ have been reported to participate in keratinocyte apoptosis. However, their levels are variable, which hampers the elucidation of the role of these cytokines. We sought to determine whether cytokine… Continue reading Variable levels of apoptotic signal-associated cytokines in the disease course of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis
No more pain upon Gq-protein-coupled receptor activation: role of endocannabinoids
The above article from European Journal of Neuroscience, published online on 4 February 2014 in Wiley Online Library (http://ift.tt/1TuP6PK), has been retracted by agreement between the Editors-in-Chief, Paul Bolam and John Foxe, the authors and John Wiley & Sons Ltd. The retraction has been agreed as the above article has been found to overlap substantially… Continue reading No more pain upon Gq-protein-coupled receptor activation: role of endocannabinoids
Issue Cover (April 2016)
Cover image by Daniel J. Hegeman, Ellie S. Hong, Vivian M. Hernández and C. Savio Chan from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1TuP6z9 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1W4bHTQ via IFTTT
Self-organized night video enhancement for surveillance systems
Abstract Night video enhancement techniques are widely used for identifying suspicious activities captured by night visual surveillance systems. However, artificial light sources present in the surroundings deteriorate the visual quality of the video captured during night. This non-uniform illumination reduces the object identification and tracking capability of a real-time visual security system. Thus, a uniform… Continue reading Self-organized night video enhancement for surveillance systems
Effect of lifestyle modifications on oxidative stress in elderly essential hypertensive patients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
2016-04-03T21-16-35Z Source: International Journal of Medical Science and Public Health Anubhav Bhatnagar, Usha Dhar, Yogesh Tripathi. Background: Cardiovascular disease (CVD) is one of the leading causes of morbidity and mortality in elderly people, while essential hypertension is a major risk factor for CVD. However, extensive experimental data support a role for increased reactive oxygen species […]
A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
The above article from European Journal of Neuroscience, published online on 5 March 2013 in Wiley Online Library (http://ift.tt/1TuP6zj), has been retracted by agreement between the Editors-in-Chief, Paul Bolam and John Foxe, the authors and John Wiley & Sons Ltd. The retraction has been agreed as Dr Phillip Barber has informed the publisher that he […]
Variable levels of apoptotic signal-associated cytokines in the disease course of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Background/Objectives Keratinocyte death is a hallmark of Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). Apoptotic signal-associated cytokines, such as TNF-α, sFasL, granulysin, sTRAIL and IFN-γ have been reported to participate in keratinocyte apoptosis. However, their levels are variable, which hampers the elucidation of the role of these cytokines. We sought to determine whether cytokine […]
No more pain upon Gq-protein-coupled receptor activation: role of endocannabinoids
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
The above article from European Journal of Neuroscience, published online on 4 February 2014 in Wiley Online Library (http://ift.tt/1TuP6PK), has been retracted by agreement between the Editors-in-Chief, Paul Bolam and John Foxe, the authors and John Wiley & Sons Ltd. The retraction has been agreed as the above article has been found to overlap substantially […]
Issue Cover (April 2016)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Cover image by Daniel J. Hegeman, Ellie S. Hong, Vivian M. Hernández and C. Savio Chan from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1TuP6z9 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1W4bHTQ via IFTTT
Self-organized night video enhancement for surveillance systems
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Night video enhancement techniques are widely used for identifying suspicious activities captured by night visual surveillance systems. However, artificial light sources present in the surroundings deteriorate the visual quality of the video captured during night. This non-uniform illumination reduces the object identification and tracking capability of a real-time visual security system. Thus, a uniform […]
Bipolar disorder
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Bipolar disorder: A mood disorder sometimes called manic-depressive illness or manic-depression that characteristically involves cycles of depression and elation or mania. Sometimes the mood switches from high to low and back again are dramatic and rapid, but more often they are gradual and slow, and intervals of normal mood may occur between the high (manic) […]
Analysis of observed surface ozone in the dry season over Eastern Thailand during 1997–2012
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: 1 September 2016 Source:Atmospheric Research, Volumes 178–179 Author(s): Nosha Assareh, Thayukorn Prabamroong, Kasemsan Manomaiphiboon, Phunsak Theramongkol, Sirakarn Leungsakul, Nawarat Mitrjit, Jintarat Rachiwong This study analyzed observed surface ozone (O3) in the dry season over a long-term period of 1997–2012 for the eastern region of Thailand and incorporated several technical tools or methods in […]
Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermo dynamic, structural and kinetic study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Biochimica et Biophysica Acta from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/224gMez via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
