Head and Neck Medicine by Alexandros G.Sfakianakis: 04/27/16

Τετάρτη 27 Απριλίου 2016

OtoRhinoLaryngology & Medicine,New Articles,April 27th,2016,a

Undiagnosed hypothyroidism presenting with sigmoid volvulus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Undiagnosed hypothyroidism presenting with sigmoid volvulus: The incidence of hypothyroidism presenting with sigmoid volvulus, a phenomenon known as myxedema pseudovolvulus, is exceedingly rare. A male in his late thirties presented to our institution with a chief complaint of abdominal pain. The patient underwent CT scan, which was consistent with massive colonic dilatation with sigmoid volvulus. He was taken to the operating room for exploration and was found to have sigmoid volvulus and underwent a segmental resection. Postoperatively, the patient was newly diagnosed with severe... περισσότερα »

Sporadic Burkitt Lymphoma Presenting as Acute Pancreatitis, Concurrent Sinusitis, and Enlarged Adenoids

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Sporadic Burkitt Lymphoma Presenting as Acute Pancreatitis, Concurrent Sinusitis, and Enlarged Adenoids: Pancreatitis and sinusitis as presentations of Burkitt lymphoma are uncommon and rarely described in children. We describe here the case of a child who presented with symptoms suggestive of sinusitis unresponsive to antibiotics, with subsequent development of abdominal symptoms due to pancreatitis. He was eventually diagnosed with Burkitt lymphoma.

Alternating hemiparesis and orolingual apraxia as manifestations of methotrexate neurotoxicity in a paediatric case of acute lymphoblastic leukaemia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Alternating hemiparesis and orolingual apraxia as manifestations of methotrexate neurotoxicity in a paediatric case of acute lymphoblastic leukaemia: A 15-year-old girl with a recent diagnosis of acute lymphoblastic leukaemia was admitted to hospital with pancytopaenia after having received high-dose intrathecal methotrexate 1 day prior. During the next week she had intermittent episodes of alternating hemiparesis associated with speech arrest lasting minutes to hours at a time. The episodes were not associated with altered level of consciousness or headache. MRI of the brain showe... περισσότερα »

A de novo 10p11.23-p12.1 deletion recapitulates the phenotype observed in WAC mutations and strengthens the role of WAC in intellectual disability and behavior disorders

Alexandros G. SfakianakisστοEvolution of a geneΠριν από 4 δευτερόλεπτα

Chromosomal microarray analysis has become a powerful diagnostic tool in the investigation of patients with intellectual disability leading to the discovery of dosage sensitive genes implicated in the manifestation of various genomic disorders. Interstitial deletions of the short arm of chromosome 10 represent rare genetic abnormalities, especially those encompassing the chromosomal region 10p11-p12. To date, only 10 postnatal cases with microdeletion of this region have been described, and all patients shared a common phenotype, including intellectual disability, abnormal behavi...περισσότερα »

Hoarseness of voice, respiratory distress and dysphagia due to giant primary posterior mediastinal ectopic goitre: a rare clinical entity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα

Hoarseness of voice, respiratory distress and dysphagia due to giant primary posterior mediastinal ectopic goitre: a rare clinical entity: Primary posterior mediastinal ectopic goitre is an extremely rare entity; we report a case of a 28-year-old man who presented with dysphagia, respiratory distress and hoarseness of voice, gradually worsening over a period of 3 months. CT scan of the thorax revealed a giant posterior mediastinal ectopic goitre. The mass was removed through a right posterolateral thoracotomy. The patient's symptoms, respiratory distress and dysphagia disappeared i... περισσότερα »

Headache and transient visual loss as the only presenting symptoms of vertebral artery dissection: a case report

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα

: a case report: Vertebral artery dissection is an important cause of stroke in the young and diagnosis is often challenging as symptoms are varied and subtle.

Acute febrile neutrophilic dermatosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα

associated with JAK-2 positive myeloproliferative disorder: We present a case of a 77-year-old man with a history of myeloproliferative disorder. He was admitted with a 2-week history of erythaema, swelling and significant pain of the right forearm following a mechanical fall at home, which had caused a skin laceration. During his admission, he developed ongoing intermittent fever and persistently elevated C reactive protein, and total white cell count. Initially, he was treated with antibiotics for suspected cellulitis. However, symptoms continued to progress, making a suitable m... περισσότερα »

Granulomatous rosacea-like facial eruption

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

in an elderly man: leukaemia cutis: Description A man in his 60s presented with a painful and non-pruritic facial eruption of 1-year duration, which was progressively worsening. He had neither ocular symptoms nor fever. He had been diagnosed with chronic lymphocytic leukaemia (CLL) 15 years prior and treated with an intravenous immunoglobulin, chlorambucil, fludarabine and cyclophosphamide combination, with rituximab on separate occasions, but had suboptimal response. His CLL had been gradually progressive in the later years. Examination of his face revealed erythaematous papules a...περισσότερα »

Nadroparin-induced skin necrosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

clinical manifestation of HIT-2 even in the absence of thrombocytopaenia: Description A 33-year-old man with chronic heart failure secondary to dilated cardiomyopathy who developed pneumonia during his stay in the intensive care unit (ICU), was started on subcutaneous nadroparin (2850 UI subcutaneously, once a day) as prophylaxis against venous thromboembolism. By day 7, he had developed a heart-shaped blistering skin lesion with central necrosis and surrounding erythaema at the nadroparin injection site (figure 1). Throughout his stay, laboratory tests revealed neither thrombocyt...περισσότερα »

Decreased vision and pendular nystagmus in both eyes

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα

Dome-shaped macula in oculocutaneous albinism: Description A 13-year-old girl with oculocutaneous albinism presented with decreased vision and pendular nystagmus in both eyes since birth. The best-corrected-visual-acuity in both eyes was 20/400 with –2.0 D sphere. Anterior segment examination of both eyes was unremarkable apart from light coloured irides. Ocular globes and motility were normal. Axial length was 23.56 and 23.52 mm in the right and left eye, respectively. Fundus of the right eye revealed lack of pigment in retinal pigment epithelium with visible large choroidal vessel... περισσότερα »

Eosinophilic granulomatosis with polyangiitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα

in two patients with {alpha}-1-antitrypsin deficiency (PiSZ): We present two cases of eosinophilic granulomatosis with polyangiitis occurring with α-1-antitrypsin deficiency, both PiSZ phenotype. The simultaneous occurrence of these two conditions has seldom been described in the literature, despite evidence of an association between α-1-antitrypsin deficiency and other forms of vasculitis. Both patients had pulmonary involvement and reported intermittent exacerbations of vasculitic symptoms. Both patients were managed on low-dose oral steroids and azathioprine remaining well with...περισσότερα »

Hypophosphataemia due to FGF-23 producing B cell non-Hodgkin's lymphoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα

Hypophosphataemia due to FGF-23 producing B cell non-Hodgkin's lymphoma: Oncogenic osteomalacia (or tumour-induced osteomalacia) is a rare paraneoplastic syndrome caused by overproduction of fibroblastic growth factor 23 (FGF-23) by tumours. Excessive production of FGF-23 can lead to severe, symptomatic hypophosphataemia. The majority of cases have been associated with benign tumours of bone or soft tissue, such as haemangiopericytomas or other neoplasms of mesenchymal origin. We present a case of a 68-year-old woman with an FGF-23 producing B cell non-Hodgkin's lymphoma. Treatment... περισσότερα »

Fishy odour to hands, feet, saliva and urine

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα

Trimethylaminuria: We report the case of a 9-year-old boy referred to secondary care with an unusual presentation of a fishy odour to his hands, feet, saliva and urine. Laboratory investigations including urine analysis and genetic testing confirmed the diagnosis of trimethylaminuria. The patient was referred to a geneticist and dietician, and consequently treated with dietary modification. He now has an arguably much improved quality of life.

Extra-axial primary non-Hodgkin's CNS lymphoma mimicking meningioma, in a 5-year-old immunocompetent child: a rare entity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα

Extra-axial primary non-Hodgkin's CNS lymphoma mimicking meningioma, in a 5-year-old immunocompetent child: a rare entity: We describe a case of a 5-year-old immunocompetent girl who presented with features of raised intracranial pressure with left eye ptosis of 1-month duration. CT scan and MRI of the brain showed an extra-axial, intensely contrast enhancing lesion in the left temporoparieto-occipital region, consistent with meningioma. On open tissue biopsy and immunohistochemistry staining, a diagnosis of B cell non-Hodgkin's lymphoma was made. Six cycles of chemotherapy with cy... περισσότερα »

Convexity subarachnoid haemorrhage secondary to internal carotid stenosis: an indication for revascularisation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα

Convexity subarachnoid haemorrhage secondary to internal carotid stenosis: an indication for revascularisation: With increasing prevalence due to an ageing population, carotid artery stenosis is a significant cause of stroke morbidity and mortality. The indication for revascularisation treatment in symptomatic carotid stenosis is widely documented and accepted in the scientific community. However, treatment of asymptomatic carotid stenosis remains controversial. We report a case of a 78-year-old woman who was admitted with a convexity subarachnoid haemorrhage (cSAH) secondary to an...περισσότερα »

The Side Effects of Facial Implants

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

The Side Effects of Facial Implants: This case report is about a 64-year-old woman who presented at the Emergency Walk-in Center with palpebral edema as well as various erythematous plaques in supraciliary and malar areas that have been gradually worsening a couple of days prior to presentation. While talking about history, the patient mentioned she was attending, for about four months, an Esthetic Private Clinic, where she was injected in various sessions with Metacrill®, as a facial lift, for beauty purpose. Due to suspecting an allergic reaction to the Metacrill and the failure o... περισσότερα »

Cell block (CB) techniques for fine-needle aspiration biopsies (FNABs)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

A superior method for cell block preparation for fine-needle aspiration biopsies: BACKGROUND Cell block (CB) techniques for fine-needle aspiration biopsies (FNABs) vary. A direct comparison of CB techniques with statistical validation was performed to identify the best method. METHODS Three CB techniques were compared: 1) FNAB rinsed in saline and clotted with plasma and thrombin (SPT); 2) FNAB rinsed in formalin and clotted with HistoGel (HG); and 3) FNAB rinsed in formalin, centrifuged, and the pellet captured in a collodion bag (ColB). FNAB was performed on 35 random surgical sp...περισσότερα »

The Effect of Implementing Gene Expression Classifier on Outcomes of Thyroid Nodules with Indeterminate Cytology

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα

The Effect of Implementing Gene Expression Classifier on Outcomes of Thyroid Nodules with Indeterminate Cytology: AbstractThyroid nodules are classified into six cytological categories under the Bethesda classification system. Two of these categories, atypical of undetermined significance (AUS) and suspicious for a follicular neoplasm (SFN), are further labeled as “indeterminate” diagnosis. Starting in June, 2012, Kansas University-Wichita Endocrine clinic implemented *Afirma*® Gene Expression Classifier (AGEC) to evaluate the need for surgical resection of thyroid nodules in patie...περισσότερα »

Incidental mastoid opacification in children on MRI

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα

Incidental mastoid opacification in children on MRI: Abstract BackgroundThe opacification the mastoid cavity is frequently reported by radiologists on cross-sectional imaging done for non-otological indications. It is well known that presence of fluid the mastoid does not amount to mastoiditis. This study seeks to provide an evidence-based confirmation of this known finding. ObjectiveThe purpose of our study was to determine the prevalence of mastoid opacification in children undergoing outpatient brain MRI examination. Materials and methodsOur study included 515 outpatient... περισσότερα »

Ultrasound and MR imaging findings in prenatal diagnosis of craniosynostosis syndromes

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα

Ultrasound and MR imaging findings in prenatal diagnosis of craniosynostosis syndromes: Abstract BackgroundCraniosynostosis syndromes are uncommonly encountered in the prenatal period. Identification is challenging but important for family counseling and perinatal management. ObjectiveThis series examines prenatal findings in craniosynostosis syndromes, comparing the complementary roles of US and MRI and emphasizing clues easily missed in the second trimester. Materials and methodsSix prenatal cases evaluated from 2002 through 2011 were retrospectively reviewed. Referral hi... περισσότερα »

Risk of cardiovascular adverse events in patients with solid tumors treated with ramucirumab

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

: A meta analysis and summary of other VEGF targeted agents via Critical Reviews in Oncology/Hematology (open access) Publication date: Available online 22 April 2016 *Source:*Critical Reviews in Oncology/Hematology Author(s): Omar Abdel-Rahman, Hesham ElHalawani BackgroundWe performed a systematic review and meta-analysis of the risk of cardiovascular adverse events associated with ramucirumab.Patients and methodsEligible studies included randomized phase II and III trials of patients with solid tumors on ramucirumab; describing events of hypertension, bleeding, arterial/venous thrombo...περισσότερα »

Efficacy and mucosal toxicity of concomitant chemo-radiotherapy in patients with locally-advanced HNSCC

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

Efficacy and mucosal toxicity of concomitant chemo-radiotherapy in patients with locally-advanced squamous cell carcinoma of the head-and-neck in the light of a novel mathematical model. via Critical Reviews in Oncology/Hematology (open access) Publication date: Available online 22 April 2016 *Source:*Critical Reviews in Oncology/Hematology Author(s): Lidia Strigari, Paola Pinnarò, Paolo Carlini, Francesco Torino, Silvia Strolin, Silvia Minosse, Giuseppe Sanguineti, Marcello Benassi BackgroundIn the last several decades, combined radiotherapy (RT) and chemotherapy (CT) have been recogni...περισσότερα »

Why Acute Dizziness and Vertigo? Articulating the Emergency Neuro-Otology Imperative.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 17 δευτερόλεπτα

[image: http:--linkinghub.elsevier.com-ihub-imag] [image: http:--http://ift.tt/1UuR80f] Related Articles *Why Acute Dizziness and Vertigo? Articulating the Emergency Neuro-Otology Imperative.* Neurol Clin. 2015 Aug;33(3):xiii-xv Authors: Newman-Toker DE, Kerber KA, Meurer WJ, Omron R, Edlow JA PMID: 26231282 [PubMed - indexed for MEDLINE] from Hearing and Balance via ola Kala on Inoreader http://ift.tt/1rhuyzb via IFTTT

Acute Diagnosis and Management of Stroke Presenting Dizziness or Vertigo.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 17 δευτερόλεπτα

[image: http:--linkinghub.elsevier.com-ihub-imag] [image: http:--http://ift.tt/1UuR80f] Related Articles *Acute Diagnosis and Management of Stroke Presenting Dizziness or Vertigo.* Neurol Clin. 2015 Aug;33(3):687-98, xi Authors: Lee SH, Kim JS Abstract Stroke involving the brainstem and cerebellum frequently presents acute vestibular syndrome. Although vascular vertigo is known to usually accompany other neurologic symptoms and signs, isolated vertigo from small infarcts involving the cerebellum or brainstem has been increasingly recognized. Bedside neuro-otologic examination can ... περισσότερα »

TiTrATE: A Novel, Evidence-Based Approach to Diagnosing Acute Dizziness and Vertigo.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 17 δευτερόλεπτα

[image: http:--linkinghub.elsevier.com-ihub-imag] [image: http:--http://ift.tt/1UuR80f] Related Articles *TiTrATE: A Novel, Evidence-Based Approach to Diagnosing Acute Dizziness and Vertigo.* Neurol Clin. 2015 Aug;33(3):577-99, viii Authors: Newman-Toker DE, Edlow JA Abstract Diagnosing dizziness can be challenging, and the consequences of missing dangerous causes, such as stroke, can be substantial. Most physicians use a diagnostic paradigm developed more than 40 years ago that focuses on the type of dizziness, but this approach is flawed. This article proposes a new paradigm ba... περισσότερα »

Prognostic microRNA signatures derived from The Cancer Genome Atlas for head and neck squamous cell carcinomas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Prognostic microRNA signatures derived from The Cancer Genome Atlas for head and neck squamous cell carcinomas: Abstract Identification of novel prognostic biomarkers typically requires a large dataset which provides sufficient statistical power for discovery research. To this end, we took advantage of the high-throughput data from The Cancer Genome Atlas (TCGA) to identify a set of prognostic biomarkers in head and neck squamous cell carcinomas (HNSCC) including oropharyngeal squamous cell carcinoma (OPSCC) and other subtypes. In this study, we analyzed miRNA-seq data obtained fro... περισσότερα »

Programmed death ligand-1 expression is associated with poor disease free survival in salivary gland carcinomas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Programmed death ligand-1 expression is associated with poor disease free survival in salivary gland carcinomas: Background and Objectives The immune checkpoint ligand programmed death ligand-1 (PD-L1) is expressed in various carcinomas and allows carcinoma cells to elude the immune system. PD-L1 expression is associated with the response to anti-programmed death 1 (PD-1)/PD-L1 drugs. This study aimed to clarify the relationship between PD-L1 expression and clinicopathological factors of salivary gland carcinomas (SGCs) and identify its clinical significance. Methods PD-L1 expressio... περισσότερα »

Double primary malignant fibrous histiocytoma and squamous cell carcinoma of the larynx treated with laser laryngeal conservation surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Double primary malignant fibrous histiocytoma and squamous cell carcinoma of the larynx treated with laser laryngeal conservation surgery: PD Karkos, S Dova, S Sotiriou, K Markou and I Kostopoulos *Βackground: *Synchronous multiple malignancies of the larynx are rare. We present a case here of synchronous primary laryngeal squamous cell carcinoma (SCC) and malignant fibrous histiocytoma (MFH) in a patient with hoarseness though with no history of exposure to radiation. Clinical, intraoperative, and histopathological findings in this patient are discussed. *Methods:* Wide laser ex...περισσότερα »

Confirmation of proposed human papillomavirus risk–adapted staging according to AJCC/UICC TNM criteria for positive oropharyngeal carcinomas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Confirmation of proposed human papillomavirus risk–adapted staging according to AJCC/UICC TNM criteria for positive oropharyngeal carcinomas: BACKGROUND Patients with human papillomavirus (HPV)–related oropharyngeal cancers (OPCs) have superior outcomes in comparison with patients with non–HPV-induced OPCs. This study confirms that a previously proposed HPV risk–adapted restaging system better reflects disease outcomes. METHODS The National Cancer Data Base was used to analyze 8803 HPV+ OPC patients. Univariate and multivariate analyses were performed to identify the utility of both... περισσότερα »

BMD : Bisphosphonates (BPs) could prevent or delay the development of skeleton-related events (SREs)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

A multicenter, retrospective epidemiologic survey of the clinical features and management of bone metastatic disease in China: Abstract BackgroundBone metastases are common in patients with advanced cancer. Bisphosphonates (BPs) could prevent or delay the development of skeleton-related events (SREs). The present study aimed to identify the clinical features of and treatment strategies for Chinese patients with bone metastases. MethodsConsecutive cancer patients who had bone metastases and received BP treatment were enrolled. A questionnaire was developed to collect the patien... περισσότερα »

Bone metastatic disease

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Squamous cell carcinoma of head and neck: distribution of risk factors by tumor location

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Epidemiological characteristics of a Spanish cohort of patients diagnosed with PurposeHead and neck cancer is a highly heterogeneous disease comprising a large number of tumors located in the cervicofacial area. This study aimed to determine the epidemiological characteristics of squamous-cell carcinomas of the head and neck in the Spanish population, and the distribution of risk factors based on tumor locations. Methods/patientsA cohort of 459 patients (75 oral cavity, 167 oro-/hypopharyngeal and 217 laryngeal cancers) recruited in 19 hospitals participating in the Spanis... περισσότερα »

Thyroid carcinoma with rhabdoid phenotype: Case report with review of the literature.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 δευτερόλεπτα

*Thyroid carcinoma with rhabdoid phenotype: Case report with review of the literature.* Auris Nasus Larynx. 2016 Apr 21; Authors: Lu YT, Huang HI, Yang AH, Tai SK Abstract OBJECTIVE: This paper aims to comprehensively document a rare case of thyroid carcinoma with rhabdoid phenotype and literature review of this disease. METHODS: A 59-year-old man presented with a rapidly enlarging, painful left lateral cervical mass. CT scan revealed a tumor over the left the thyroid gland with multiple left cervical lymphadenopathy over left level II-IV and level VI. Fine-needle aspiration cyto... περισσότερα »

Branchial cleft-like cysts in Hashimoto's thyroiditis: A case report and literature review.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 δευτερόλεπτα

*Branchial cleft-like cysts in Hashimoto's thyroiditis: A case report and literature review.* Pathol Int. 2016 May;66(5):297-301 Authors: Miyazaki M, Kiuchi S, Fujioka Y Abstract We report an extremely rare case of branchial cleft-like cysts in Hashimoto's thyroiditis. The patient was a 77-year-old man with a growing mass in the anterior neck. Ultrasonography and computed tomography revealed a cystic lesion with septum in the left thyroid and multiple small cystic lesions in the right thyroid. Lymph node swelling of the cervical region, supraclavicular fossa and submandibular reg... περισσότερα »

[Study on the hemodynamic changes in solid thyroid nodules by ultrasound contrast quantitative analysis].

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 δευτερόλεπτα

Related Articles *[Study on the hemodynamic changes in solid thyroid nodules by ultrasound contrast quantitative analysis].* Zhonghua Yi Xue Za Zhi. 2015 Nov 17;95(43):3519-22 Authors: Wu C, Zhu L, Chen W, Yan S, Qian L, Zhao C, Xie G, Zheng X Abstract OBJECTIVE: To compare the difference between the different perfusional regions in solid thyroid nodules. METHODS: From October 2013 to May 2015, CEUS was performed in 59 patients who hospitalizated in Zhoushan Hospital with solid thyroid nodules before operation. The time-intensity curve (TIC) of normal thyroid tissue, tumor edge a...περισσότερα »

microRNA-762 promotes breast cancer cell proliferation and invasion by targeting IRF7 expression.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 δευτερόλεπτα

[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *microRNA-762 promotes breast cancer cell proliferation and invasion by targeting IRF7 expression.* Cell Prolif. 2015 Dec;48(6):643-9 Authors: Li Y, Huang R, Wang L, Hao J, Zhang Q, Ling R, Yun J Abstract OBJECTIVES: miRNAs play crucial roles in human tumourigenesis. This study was performed to measure expression and function of miR-762 in breast cancer. MATERIALS AND METHODS: Expression of miR-762 in breast tissues and cell lines (SK-BR-3, DA-MB-435s, MCF-7 and MDA-MB-231, HBL-100) was measured by using real-time... περισσότερα »

SUVmax of 18F-FDG PET/CT in the differential diagnosis of benign and malignant thyroid nodules according to tumor volume.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 δευτερόλεπτα

[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *SUVmax of 18F-FDG PET/CT in the differential diagnosis of benign and malignant thyroid nodules according to tumor volume.* World J Surg Oncol. 2015;13:217 Authors: Kim TH, Ji YB, Song CM, Kim JY, Choi YY, Park JS, Tae K Abstract BACKGROUND: The aim of this study was to investigate whether the maximum standardized uptake value (SUVmax) measured on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) could be used as the primary means of differen...περισσότερα »

Computerized analysis of calcification of thyroid nodules as visualized by ultrasonography.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 δευτερόλεπτα

[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Computerized analysis of calcification of thyroid nodules as visualized by ultrasonography.* Eur J Radiol. 2015 Oct;84(10):1949-53 Authors: Choi WJ, Park JS, Kim KG, Kim SY, Koo HR, Lee YJ Abstract OBJECTIVE: The purpose of this study is to quantify computerized calcification features from ultrasonography (US) images of thyroid nodules in order to determine the ability to differentiate between malignant and benign thyroid nodules. METHODS: We designed and implemented a computerized analysis scheme to quantitative... περισσότερα »

Improving the approach to non-diagnostic aspirates: learning from each other.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 δευτερόλεπτα

[image: http:--production.springer.de-OnlineReso] Related Articles *Improving the approach to non-diagnostic aspirates: learning from each other.* Endocrine. 2015 Aug;49(3):575-6 Authors: Alexander EK PMID: 25837308 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1Nzhqzr via IFTTT

A reference image-based method for optimization of clinical immunohistochemistry.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 δευτερόλεπτα

[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *A reference image-based method for optimization of clinical immunohistochemistry.* Histopathology. 2015 Aug;67(2):193-205 Authors: Kap M, Lam KH, Ewing-Graham P, Riegman P Abstract AIMS: Cold ischaemic and formalin fixation time (CIT and FFT) are considered to be crucial parameters for intralaboratory variation in immunohistochemistry (IHC). Here we describe a new method to optimize IHC, by using control tissue blocks with known pre-analytical history and comparing the IHC outcome with digitized reference slides.... περισσότερα »

Prevalence of incidental thyroid nodules in ultrasound studies of dogs with hypercalcemia (2008-2013).

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα

[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Prevalence of incidental thyroid nodules in ultrasound studies of dogs with hypercalcemia (2008-2013).* Vet Radiol Ultrasound. 2015 Jan-Feb;56(1):63-7 Authors: Pollard RE, Bohannon LK, Feldman EC Abstract Ultrasound is commonly used to evaluate the cervical region in dogs with hypercalcemia due to suspected hyperparathyroidism. Incidental thyroid nodules may be detected during these studies, however little information has been published to guide clinical decision-making when this occurs. The purpose of this cross... περισσότερα »

Thyroid scintigraphy findings in 2096 cats with hyperthyroidism.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα

[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Thyroid scintigraphy findings in 2096 cats with hyperthyroidism.* Vet Radiol Ultrasound. 2015 Jan-Feb;56(1):84-95 Authors: Peterson ME, Broome MR Abstract Thyroid scintigraphy is currently the reference standard for diagnosing and staging cats with hyperthyroidism, but few studies describing the scintigraphic characteristics in a large number of cats have been reported. The objective of this study was to better characterize thyroid scintigraphy findings by evaluating 2096 consecutive cats with hyperthyroidism that... περισσότερα »

Application of quality-by-design approach to optimize diallyl disulfide-loaded solid lipid nanoparticles.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα

*Application of quality-by-design approach to optimize diallyl disulfide-loaded solid lipid nanoparticles.* Artif Cells Nanomed Biotechnol. 2016 Apr 25;:1-15 Authors: Talluri SV, Kuppusamy G, Karri VV, Yamjala K, Wadhwani A, Madhunapantula SV, Pindiprolu SS Abstract The current work was carried out by the principles of quality-by-design approach to develop an optimized solid lipid nanoparticles (SLNs) formulation of diallyl disulfide (DADS) through systematic statistical study. And its antitumor activity of DADS was also evaluated on breast cancer cell lines. To understand the ef... περισσότερα »

Targeted cancer therapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα

interactions with other medicines: AbstractTargeted therapy drugs, mainly those within the signal transduction inhibitors, are used more chronically than cytotoxic drugs and are metabolised by cytochrome P450 isozymes so patients are at high risk of having drug–drug interactions (DDI). Not only this, as the majority of them are given orally, new drug–drug interactions concerning gastrointestinal absorption can occur (e.g., with proton pump inhibitors). DDI can lead to changed systemic exposure, resulting in variations in drug response of the co-administered. In addition, concomitan... περισσότερα »

Pediatric mature B cell non-Hodgkin’s lymphoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα

Role of FDG-PET scan in the management of pediatric mature B cell non-Hodgkin’s lymphoma. CCHE experience via ScienceDirect Publication: Journal of the Egyptian National Cancer Institute Publication date: Available online 25 April 2016 *Source:*Journal of the Egyptian National Cancer Institute Author(s): Hany Abdel Rahman, Mohamed Sedky, Asmaa Hamoda, Tarek Raafat, Ayda Youssef, Walid Omar, Omneya Hassanein, Emad Moussa Aim of workTo evaluate the sensitivity (Se), specificity (Sp), and predictive values (PV) of PET scan during management of pediatric mature B cell non-Hodgkin’s lymphom... περισσότερα »

Posterior mediastinal intrathoracic goiter

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα

Posterior mediastinal intrathoracic goiter: Honglin Zhao,* Dian Ren,* Yi Liu, Xin Li, Yi Wu, Gang Chen, Jun Chen Department of Lung Cancer Surgery, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China *These authors contributed equally to this work *Abstract:* Intrathoracic goiters generally occupy anterior mediastinum, rarely involving the posterior mediastinal space. Reported herein is a 54-year-old female with a giant posterior mediastinal mass that was successfully resected via right posterolateral thoracotomy. The... περισσότερα »

Posterior mediastinal intrathoracic goiter

Alexandros G. SfakianakisστοHead and NeckΠριν από 24 δευτερόλεπτα

upper respiratory tract infection; +48 new citations

Alexandros G. SfakianakisστοHead and NeckΠριν από 25 δευτερόλεπτα

48 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/04/27 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1TdydEH via IFTTT

Vitamin D-fortified bread is as effective as supplement in improving vitamin D status: a randomized clinical trial.

Alexandros G. SfakianakisστοHead and NeckΠριν από 25 δευτερόλεπτα

*Vitamin D-fortified bread is as effective as supplement in improving vitamin D status: a randomized clinical trial.* J Clin Endocrinol Metab. 2016 Apr 26;:jc20161631 Authors: Nikooyeh B, Neyestani TR, Zahedirad M, Mohammadi M, Hedayat Hosseini S, Abdollahi Z, Salehi F, Mirzay Razaz J, Shariatzadeh N, Kalayi A, Lotfollahi N, Maleki MR Abstract CONTEXT: Bread can potentially be a suitable vehicle for fortification with vitamin D. OBJECTIVE: This study was undertaken to evaluate (1) bioavailability of vitamin D from the fortified Iranian bread, and (2) the possible effects of daily... περισσότερα »

Secular changes in post-fracture outcomes over 2 decades in Australia: A time-trend comparison of excess post-fracture mortality in two birth controls over two decades.

Alexandros G. SfakianakisστοHead and NeckΠριν από 25 δευτερόλεπτα

*Secular changes in post-fracture outcomes over 2 decades in Australia: A time-trend comparison of excess post-fracture mortality in two birth controls over two decades.* J Clin Endocrinol Metab. 2016 Apr 26;:jc20161514 Authors: Bliuc D, Tran T, Alarkawi D, Nguyen TV, Eisman JA, Center JR Abstract CONTEXT: Hip fracture incidence has been declining and life expectancy improving. However, trends of post-fracture outcomes are unknown. OBJECTIVES: To compare re-fracture risk and excess mortality following osteoporotic fracture between two birth cohorts, over two decades. DESIGN: Prospe...περισσότερα »

Different effects of intraperitoneal and subcutaneous insulin administration on the GH-IGF-1 axis in type 1 diabetes.

Alexandros G. SfakianakisστοHead and NeckΠριν από 25 δευτερόλεπτα

*Different effects of intraperitoneal and subcutaneous insulin administration on the GH-IGF-1 axis in type 1 diabetes.* J Clin Endocrinol Metab. 2016 Apr 26;:jc20161473 Authors: van Dijk PR, Logtenberg SJ, Chisalita SI, Hedman CA, Groenier KH, Gans RO, Kleefstra N, Arnqvist HJ, Bilo HJ Abstract CONTEXT: In type 1 diabetes mellitus (T1DM), low levels of insulin-like growth factor -1 (IGF-1) and IGF binding protein-3 (IGFBP-3) and high levels of growth hormone (GH) and IGFBP-1 are present, probably due to portal vein insulinopenia. OBJECTIVE: To test the hypothesis that continuous i... περισσότερα »

Advanced Glycation Endproducts and Bone Material Strength in Type 2 Diabetes.

Alexandros G. SfakianakisστοHead and NeckΠριν από 25 δευτερόλεπτα

*Advanced Glycation Endproducts and Bone Material Strength in Type 2 Diabetes.* J Clin Endocrinol Metab. 2016 Apr 26;:jc20161437 Authors: Furst JR, Bandeira LC, Fan WW, Agarwal S, Nishiyama KK, McMahon DJ, Dworakowski E, Jiang H, Silverberg SJ, Rubin MR Abstract CONTEXT: Skeletal deterioration, leading to an increased risk of fracture, is a known complication of type 2 diabetes mellitus (T2D). Yet plausible mechanisms to account for skeletal fragility in T2D have not been clearly established. OBJECTIVE: To determine whether bone material properties, as measured by reference point...περισσότερα »

Human Papillomavirus and Oropharyngeal Cancer Stage

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα

- © 2016 by American Society of Clinical Oncology Human Papillomavirus and Oropharyngeal Cancer Stage 1. Maura L. Gillison⇑ -Author Affiliations 1. Ohio State University 1. Corresponding author: Maura L. Gillison, MD, PhD, Ohio State University, 420 W 12th Ave, Room 620, Columbus, OH 43210; e-mail: maura.gillison@osumc.edu Head and neck squamous cell carcinomas (HNSCCs) are now stratified into two major subgroups: those caused by human papillomavirus (HPV) infection and those that are not. Distinct in many ways, the most clinically significant difference b... περισσότερα »

Highly vascular tumors of the eyes, brain, and spine, as well as benign and malignant tumors and/or cysts of the kidneys, adrenal medullae and sympathetic paraganglia, endolymphatic sac, epididymis, and broad ligament.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα

Von Hippel-Lindau Disease: Genetics and Role of Genetic Counseling in a Multiple Neoplasia Syndrome [REVIEW ARTICLE]: Von Hippel-Lindau disease (VHL) is one of the most common inherited neoplasia syndromes and is characterized by highly vascular tumors of the eyes, brain, and spine, as well as benign and malignant tumors and/or cysts of the kidneys, adrenal medullae and sympathetic paraganglia, endolymphatic sac, epididymis, and broad ligament. Since the discovery of the *VHL* gene in 1993, more than 900 families with VHL have been identified and examined. Genetic testing for *VHL*... περισσότερα »

223RaCl2 in the treatment of bone metastases

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα

From palliative therapy to prolongation of survival: 223RaCl2 in the treatment of bone metastases: Patients with hormone-refractory prostate cancer often have multiple bone metastases. The resulting bone pain is associated with reduced life quality, increased cost of therapy and impairment of overall survival. Trials with bone-targeting β-emitters have mostly showed an effect on alleviation of bone pain along with prolongation in survival, documented in only a limited number of patients. A randomized phase III trial (ALSYMPCA) using the α-emitter 223RaCl2 (Xofigo®) showed for the f... περισσότερα »

Nodular, ulcerated, polypoid, papillomatous and often non-pigmented...Balloon Cell Malignant Melanoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα

Balloon Cell Malignant Melanoma in a Young Female: A Case Report and Review of the Literature: Balloon cell malignant melanoma (BCMM) is a very rare malignant melanoma subtype. The clinical appearance of BCMM varies; it may be nodular, ulcerated, polypoid, papillomatous and often non-pigmented. The tumor cells histologically appear large, polygonal or round and contain abundant granular or vacuolated cytoplasm. We herein report the case of a 32-year-old female who presented with a focal eccentric pigmented mass in the left lumbar region of 15 mm in diameter that had been present for ...περισσότερα »

Malignant Nodular Fasciitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα

PPP6R3-USP6 Amplification: Novel Oncogenic Mechanism in Malignant Nodular Fasciitis: ABSTRACT Nodular fasciitis (NF) is a clonal self-limited neoplastic proliferation characterized by rearrangements of the *USP6* locus in most examples. To our knowledge well-documented malignant behavior has never been previously observed in NF. In this report we present an unusual case of NF with classical histologic features that showed a protracted clinical course characterized by multiple recurrences and eventual metastatic behavior over a period of 10 years. Molecular analyses revealed the pre... περισσότερα »

Fluoropyrimidine-Induced Cardiotoxicity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα

Manifestations, Mechanisms, and Management: AbstractFluoropyrimidines—5-fluorouracil (5-FU) and capecitabine—have been implicated as cardiotoxic chemotherapy agents. This rare, albeit potentially serious toxicity has been described in nearly four decades of case reports, case series, and in vitro modeling; however, there is a paucity in clinical trials and prospective analyses focused on cardioprotective strategies and cardiotoxic surveillance of these agents. While much attention has focused on the well-known cardiac toxicity of anthracyclines and monoclonal antibody agents such a...περισσότερα »

Response-adapted volume de-escalation (RAVD) in locally advanced head and neck cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα

Response-adapted volume de-escalation (RAVD) in locally advanced head and neck cancer: Background Efforts to reduce the late toxicity associated with chemoradiation (CRT) for locally advanced head and neck squamous cell cancer (LA-HNSCC) have focused on radiotherapy (RT) dose de-escalation. In this phase I/II protocol investigating the addition of everolimus to induction chemotherapy (IC), we incorporated a novel response-adapted volume de-escalation (RAVD) approach using IC response to guide the extent of RT volume reduction. Patients and methods Patients with measurable LA-HNSCC ... περισσότερα »

Merkel cell carcinoma: value of sentinel lymph-node status and adjuvant radiation therapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα

Merkel cell carcinoma: value of sentinel lymph-node status and adjuvant radiation therapy: Background Sentinel lymph-node (LN) biopsy (SLNB) is a valuable tool to assess the regional LN status in Merkel cell carcinoma (MCC). However, its prognostic value is still debated. This study was undertaken to assess SLNB usefulness for MCC management and to determine the impact of SLNB status on disease-free survival (DFS) and overall survival (OS) by comparing SLNB-positive versus -negative patients according to demographic, clinical and treatment characteristics. Patients and methods In ...περισσότερα »

Mammary analogue secretory carcinoma (MASC)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα

What hides behind the MASC: clinical response and acquired resistance to entrectinib after ETV6-NTRK3 identification in a mammary analogue secretory carcinoma (MASC): Background Mammary analogue secretory carcinoma (MASC) is a recently described pathologic entity. We report the case of a patient with an initial diagnosis of salivary acinic cell carcinoma later reclassified as MASC after next-generation sequencing revealed an *ETV6-NTRK3* fusion. Patients and methods This alteration was targeted with the pan-Trk inhibitor entrectinib (Ignyta), which possesses potent *in vitro* activ...περισσότερα »

Increased cancer risk has been reported among workers in the rubber manufacturing industry

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα

Cancer mortality in cohorts of workers in the European rubber manufacturing industry first employed since 1975: Background Increased cancer risk has been reported among workers in the rubber manufacturing industry employed before the 1960s. It is unclear whether risk remains increased among workers hired subsequently. The present study focused on risk of cancer mortality for rubber workers first employed since 1975 in 64 factories. Patients and methods Anonymized data from cohorts of rubber workers employed for at least 1 year from Germany, Italy, Poland, Sweden, and the UK were po...περισσότερα »

Development of polymeric micelles

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα

for targeting intractable cancers: Abstract In relation to recent advances in nanobiotechnologies, cancer targeted therapy utilizing nano-scaled drug carriers (nanocarriers) has been attracting increasing attention. Polymeric micelles, core-shell type nanoparticles formed through the self-assembly of block copolymers, are one of the most promising nanocarrier, because their critical features such as size, stability and drug incorporation […]

Influence of deprivation on health-related quality of life of patients with cancer of the head and neck in Merseyside and Cheshire

Publication date: Available online 27 April 2016 Source:British Journal of Oral and Maxillofacial Surgery Author(s): J. Rylands, D. Lowe, S.N. Rogers The incidence of cancer of the head and neck, and the outcome of treatment in terms of survival and health-related quality of life (HRQoL), is linked to deprivation. We have explored the association of […]

Electrochemical treatment: an effective way of dealing with extensive venous malformations of the oral and cervicofacial region

Publication date: Available online 27 April 2016 Source:British Journal of Oral and Maxillofacial Surgery Author(s): Hao-Yan Zhong, Yu Cai, Yi-Fang Zhao, Xin Yang, Li Liu, Ji-Hong Zhao We describe the results of electrochemical treatment of extensive venous malformations in the oral and cervicofacial region in 29 patients. Platinum needles were inserted into the lesions under […]

“Current thinking” articles in BJOMS: are they for everyone?

Publication date: Available online 27 April 2016 Source:British Journal of Oral and Maxillofacial Surgery Author(s): Nabeela Ahmed, Andrew J. Sidebottom from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1WpyN7m via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/235VHkp via IFTTT

Ectopic ACTH syndrome caused by thymic neuroendocrine tumors

Treatment of chronic chemotherapy-induced peripheral neuropathy using long-wave diathermy and interferential currents

Use of olanzapine for the relief of nausea and vomiting

Safe and effective deodorization of malodorous fungating tumors using topical metronidazole 0.75 % gel

(GK567): a multicenter, open-label, phase III study (RDT.07.SRE.27013): Abstract Purpose Malignant fungating tumors are neoplastic tumors associated with skin ulcers, which are susceptible to microbial colonization. Bacterial infection and proliferation may lead to malodor causing distress to patients. Metronidazole—an effective agent against anaerobes—may contribute to deodorization and improvement in quality of life (QOL). This study […]

Topical application of Aloe vera and vitamin E on induced ulcers on the tongue

Nausea as a sentinel symptom for cytotoxic chemotherapy

Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 31 δευτερόλεπτα

[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice.* Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R552-60 Authors: Glendinning JI, Stano S, Holter M, Azenkot T, Goldman O, Margolskee RF, Vasselli JR, Sclafani A Abstract Sensory stimulation from foods elicits cephalic phase responses, which facilitate digestion and nutrient assimilation. One such response, cephalic-phase insulin release (CPIR), enhan... περισσότερα »

Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 31 δευτερόλεπτα

Periodontal disease and risk of all cancers among male never smokers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

an updated analysis of the Health Professionals Follow-up Study: Background Periodontal disease has a direct impact on the immune response and has been linked to several chronic diseases, including atherosclerosis and stroke. Few studies have examined the association between periodontal disease and cancer. Patients and methods A total of 19 933 men reported being never smokers (of cigarette, pipes or cigars) in the Health Professionals' Follow-up Study. Periodontal disease status and teeth number were self-reported at baseline and during follow-up. All cancers were ascertained duri...περισσότερα »

Panobinostat and epirubicin in solid tumors with a dose expansion in patients with sarcoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

A phase I trial of Treatment options for sarcoma are limited. Histone deacetylase inhibitors increase the efficacy of topoisomerase II inhibitors by promoting access to chromatin and by down-regulating DNA repair. Thus, combined panobinostat and epirubicin therapy was evaluated to treat refractory sarcoma. Patients and methods Patients with advanced solid tumors were enrolled in a 3 + 3 dose-escalation phase I trial of panobinostat given on days 1, 3, and 5 followed by 75 mg/m2 of epirubicin on day 5 in 21-day cycles, with a dose expansion at maximum tolerated dose (MTD) in 20 s... περισσότερα »

Development of polymeric micelles

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

Ectopic ACTH syndrome caused by thymic neuroendocrine tumors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

Ectopic ACTH syndrome caused by thymic neuroendocrine tumors: Ye-ye Chen,1 Shan-qing Li,1,2 Hong-sheng Liu,1,2 Ying-zhi Qin,1 Li Li,1 Cheng Huang,1 Ya-lan Bi,3Yun-xiao Meng,3 Jia He,1 Xiao-yun Zhou,1 Dong-jie Ma1 1Department of Thoracic Surgery, 2Key Laboratory of Endocrinology, 3Department of Pathology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China *Background and purpose:* Thymic neuroendocrine carcinomas (TNECs) are extremely uncommon. Certain cases of TNECs can pro... περισσότερα »

Treatment of chronic chemotherapy-induced peripheral neuropathy using long-wave diathermy and interferential currents

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

s: a randomized controlled trial: Abstract PurposeThe purpose was to investigate the effects of long-wave diathermy in combination with interferential currents (interferential therapy and long-wave diathermy at high power (ITH)) in comparison with long-wave diathermy at a power below the active treatment dose (long-wave diathermy at low power (LDL), control group) on sensory and motor symptoms in patients with chronic chemotherapy-induced peripheral neuropathy (CIPN) in the lower extremities. MethodsSixty-seven patients with chronic CIPN were randomized to 12 weeks of either I... περισσότερα »

Use of olanzapine for the relief of nausea and vomiting

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

in patients with advanced cancer: a multicenter survey in Japan: AbstractNausea and vomiting are among the most common and distressing symptoms in patients with advanced cancer. Olanzapine, an antipsychotic agent, is known to have an affinity for multiple neurotransmitter receptors. Previous studies have reported olanzapine to be efficacious in the treatment of nausea and vomiting. Although it has been administered at a number of facilities, its applicability to treat nausea and vomiting in patients with advanced cancer is poorly understood. We investigated the use of olanzapine f... περισσότερα »

Safe and effective deodorization of malodorous fungating tumors using topical metronidazole 0.75 % gel

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα

(GK567): a multicenter, open-label, phase III study (RDT.07.SRE.27013): Abstract PurposeMalignant fungating tumors are neoplastic tumors associated with skin ulcers, which are susceptible to microbial colonization. Bacterial infection and proliferation may lead to malodor causing distress to patients. Metronidazole—an effective agent against anaerobes—may contribute to deodorization and improvement in quality of life (QOL). This study investigated the efficacy and safety of topical metronidazole 0.75 % gel for alleviation of malodor in anaerobically infected fungating neoplastic t... περισσότερα »

Influence of deprivation on health-related quality of life of patients with cancer of the head and neck in Merseyside and Cheshire

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 32 δευτερόλεπτα

Publication date: Available online 27 April 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): J. Rylands, D. Lowe, S.N. Rogers The incidence of cancer of the head and neck, and the outcome of treatment in terms of survival and health-related quality of life (HRQoL), is linked to deprivation. We have explored the association of social deprivation with HRQoL and with fear of recurrence in patients treated for cancer of the head and neck in Merseyside and Cheshire. In 2013, we posted cross-sectional surveys to 805 patients treated for oral, oropharyngeal, or la... περισσότερα »

Electrochemical treatment: an effective way of dealing with extensive venous malformations of the oral and cervicofacial region

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 32 δευτερόλεπτα

Publication date: Available online 27 April 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Hao-Yan Zhong, Yu Cai, Yi-Fang Zhao, Xin Yang, Li Liu, Ji-Hong Zhao We describe the results of electrochemical treatment of extensive venous malformations in the oral and cervicofacial region in 29 patients. Platinum needles were inserted into the lesions under general or local anaesthesia, the electrode pitch, voltage, current, and quantity of electricity being 1-1.5cm, 5-8V, 40-60mA, and 50-60C/cm2, respectively. Six months after the treatment, 26 patients had bee... περισσότερα »

“Current thinking” articles in BJOMS: are they for everyone?

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 32 δευτερόλεπτα

Publication date: Available online 27 April 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Nabeela Ahmed, Andrew J. Sidebottom from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1WpyN7m via IFTTT

Sleep spindles during a nap correlate with post sleep memory performance for highly rewarded word-pairs

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 42 δευτερόλεπτα

[image: S0093934X.gif] Publication date: Available online 26 April 2016 *Source:*Brain and Language Author(s): Sara Studte, Emma Bridger, Axel Mecklinger The consolidation of new associations is thought to depend in part on physiological processes engaged during non-REM (NREM) sleep, such as slow oscillations and sleep spindles. Moreover, NREM sleep is thought to selectively benefit associations that are adaptive for the future. In line with this, the current study investigated whether different reward cues at encoding are associated with changes in sleep physiology and memory reten...περισσότερα »

Pretreatment Acoustic Predictors of Gender, Femininity, and Naturalness Ratings in Individuals With Male-to-Female Gender Identity.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 42 δευτερόλεπτα

*Pretreatment Acoustic Predictors of Gender, Femininity, and Naturalness Ratings in Individuals With Male-to-Female Gender Identity.* Am J Speech Lang Pathol. 2016 Apr 26;:1-13 Authors: Hardy TL, Boliek CA, Wells K, Dearden C, Zalmanowitz C, Rieger JM Abstract Purpose: The purpose of this study was to describe the pretreatment acoustic characteristics of individuals with male-to-female gender identity (IMtFGI) and investigate the ability of the acoustic measures to predict ratings of gender, femininity, and vocal naturalness. Method: This retrospective descriptive study included 2 ... περισσότερα »

Anterior Cervical Discectomy and Fusion with Stand-Alone Trabecular Metal Cages as a Surgical Treatment for Cervical Radiculopathy: Mid-Term Outcomes.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 42 δευτερόλεπτα

*Anterior Cervical Discectomy and Fusion with Stand-Alone Trabecular Metal Cages as a Surgical Treatment for Cervical Radiculopathy: Mid-Term Outcomes.* Asian Spine J. 2016 Apr;10(2):245-50 Authors: ElAbed K, Shawky A, Barakat M, Ainscow D Abstract STUDY DESIGN: Retrospective case cohort study done between 2002 and 2012. PURPOSE: To assess the mid-term clinical and radiological outcomes of 1-level and 2-level anterior cervical discectomy and fusion (ACDF) with stand-alone trabecular metal cages. OVERVIEW OF LITERATURE: ACDF is the gold standard surgical treatment for cervical dege... περισσότερα »

Hoarseness of voice, respiratory distress and dysphagia due to giant primary posterior mediastinal ectopic goitre: a rare clinical entity.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 42 δευτερόλεπτα

*Hoarseness of voice, respiratory distress and dysphagia due to giant primary posterior mediastinal ectopic goitre: a rare clinical entity.* BMJ Case Rep. 2016;2016 Authors: Chaudhry IU, Cheema AI, AlShamasi Z, Mutairi H Abstract Primary posterior mediastinal ectopic goitre is an extremely rare entity; we report a case of a 28-year-old man who presented with dysphagia, respiratory distress and hoarseness of voice, gradually worsening over a period of 3 months. CT scan of the thorax revealed a giant posterior mediastinal ectopic goitre. The mass was removed through a right postero... περισσότερα »

Impact of voice and communication deficits for individuals with cervical spinal cord injury living in the community.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 42 δευτερόλεπτα

*Impact of voice and communication deficits for individuals with cervical spinal cord injury living in the community.* Int J Lang Commun Disord. 2016 Apr 26; Authors: Ward EC, Jarman L, Cornwell PL, Amsters DI Abstract BACKGROUND: Post-spinal cord injury (SCI), individuals may exhibit mild to moderate impairments in aspects of speech influenced by impaired respiratory support. However, limited research has been conducted into the impact of these impairments on activity and participation when living in the community. AIMS: To examine the nature and extent of voice and communication...περισσότερα »

Foster carer experience in Spain: Analysis of the vulnerabilities of a permanent model.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 42 δευτερόλεπτα

*Foster carer experience in Spain: Analysis of the vulnerabilities of a permanent model.* Psicothema. 2016 May;28(2):122-9 Authors: López López M, Del Valle JF Abstract BACKGROUND: The voice of foster families is a valuable tool in the development and improvement of foster family services. Regularly evaluating the satisfaction of foster carers can facilitate the early identification of a range of problems that might pose a risk to the placement. METHOD: This article reports the experience of 200 Spanish foster families (kinship and non-kinship) with foster services in relation to ... περισσότερα »

Improving health care workers' protection against infection of Ebola hemorrhagic fever through video surveillance.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 42 δευτερόλεπτα

*Improving health care workers' protection against infection of Ebola hemorrhagic fever through video surveillance.* Am J Infect Control. 2016 Apr 21; Authors: Xi H, Cao J, Liu J, Li Z, Kong X, Wang Y, Chen J, Ma S, Zhang L Abstract BACKGROUND: The purpose of this study was to investigate the importance of supervision through video surveillance in improving the quality of personal protection in preparing health care workers working in Ebola treatment units. METHODS: Wardens supervise, remind, and guide health care workers' behavior through onsite voice and video systems when they ...περισσότερα »

Arytenoid adduction combined with nerve-muscle pedicle flap implantation or type I thyroplasty.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 42 δευτερόλεπτα

*Arytenoid adduction combined with nerve-muscle pedicle flap implantation or type I thyroplasty.* Laryngoscope. 2016 Apr 26; Authors: Kodama N, Kumai Y, Sanuki T, Yumoto E Abstract OBJECTIVES/HYPOTHESIS: To evaluate vocal function after refined nerve-muscle pedicle (NMP) flap implantation with arytenoid adduction (AA) compared with type I thyroplasty with AA for patients with unilateral vocal fold paralysis (UVFP) and to evaluate the degree of patient satisfaction following the refined NMP with AA. STUDY DESIGN: A retrospective review of clinical records of 52 patients with UVFP ... περισσότερα »

The Value of Vocal Extent Measure (VEM) Assessing Phonomicrosurgical Outcomes in Vocal Fold Polyps.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 42 δευτερόλεπτα

*The Value of Vocal Extent Measure (VEM) Assessing Phonomicrosurgical Outcomes in Vocal Fold Polyps.* J Voice. 2016 Apr 21; Authors: Salmen T, Ermakova T, Möller A, Seipelt M, Weikert S, Rummich J, Gross M, Nawka T, Caffier PP Abstract OBJECTIVE: This study aimed to present vocal extent measure (VEM), demonstrate its changes with phonomicrosurgical treatment in patients with vocal fold polyps (VFPs), and to compare its performance to that of established vocal parameters. STUDY DESIGN: This is an individual cohort study. METHODS: Microlaryngoscopic ablation was executed in 61 patie... περισσότερα »

Incidence of velopharyngeal insufficiency and oronasal fistulae after cleft palate repair: A retrospective study of children referred to Isfahan Cleft Care Team between 2005 and 2009.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 42 δευτερόλεπτα

[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Incidence of velopharyngeal insufficiency and oronasal fistulae after cleft palate repair: A retrospective study of children referred to Isfahan Cleft Care Team between 2005 and 2009.* Int J Pediatr Otorhinolaryngol. 2015 Oct;79(10):1722-6 Authors: Hosseinabad HH, Derakhshandeh F, Mostaajeran F, Abdali H, Davari HA, Hassanzadeh A, Kummer AW Abstract OBJECTIVE: The purpose of this study is to determine the incidence of velopharyngeal insufficiency (VPI) and fistulae development in patients seen by the Isfahan Cleft... περισσότερα »

Furlow palatoplasty for previously repaired cleft palate with velopharyngeal insufficiency.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 42 δευτερόλεπτα

[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Furlow palatoplasty for previously repaired cleft palate with velopharyngeal insufficiency.* Int J Pediatr Otorhinolaryngol. 2015 Oct;79(10):1748-51 Authors: Abdel-Aziz M, Nassar A, Rashed M, Naguib N, El-Tahan AR Abstract OBJECTIVE: Velopharyngeal insufficiency (VPI) is a common complication after cleft palate repair, it may be due to lack of levator sling reconstruction and/or palatal shortening. Furlow palatoplasty has the advantages of retro-positioning of levator palati muscles and palatal lengthening. The ai... περισσότερα »

Restricted activity and persistent pain following motor vehicle collision among older adults: a multicenter prospective cohort study

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα

BMC Geriatrics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1NzrMPR via IFTTT

Leicester doctor reducing asthma admissions

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα

University of Leicester News from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1NSNJE8 via IFTTT

An Asian perspective on improving outcomes for nasal bone fractures by establishing specific treatment options

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα

Clinical Otolaryngology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1NzrMPP via IFTTT

Are money problems and violence related?

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα

The University of Iowa Health News from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1NSNHwd via IFTTT

Topical application of Aloe vera and vitamin E on induced ulcers on the tongue

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα

of rats subjected to radiation: clinical and histological evaluation: Abstract ObjectiveThe aim of this study is to assess the effect of two types of antioxidants, vitamin E (VE) and *Aloe vera* (AV), on healing of induced oral lesions after radiation in a murine model by clinical and histological analysis. MethodsThe animals were randomly divided into three groups of 12 animals each (400 mg VE, 70 % AV and control) and two time periods (5 and 7 days). They were irradiated with a single dose of 30 Gy, and after 24 h, a lesion was produced on the ventral tongue of each animal. ... περισσότερα »

Nausea as a sentinel symptom for cytotoxic chemotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

effects on the gut-brain axis among women receiving treatment for recurrent ovarian cancer: an exploratory analysis: Abstract PurposeNausea is a common and potentially serious effect of cytotoxic chemotherapy for recurrent ovarian cancer and may function as a sentinel symptom reflecting adverse effects on the gut-brain axis (GBA) more generally, but research is scant. As a first exploratory test of this GBA hypothesis, we compared women reporting nausea to women not reporting nausea with regard to the severity of other commonly reported symptoms in this patient population. Me... περισσότερα »

Cranial radiation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα

Play-based procedural preparation and support intervention for Abstract PurposeThe primary objective of this study was to examine the relationship between play-based procedural preparation and support intervention and use of sedation in children with central nervous system (CNS) tumors during radiation therapy. The secondary objective was to analyze the cost-effectiveness of the intervention compared to costs associated with daily sedation. MethodsA retrospective chart review was conducted, and 116 children aged 5–12 years met criteria for inclusion. Outcome measures included t... περισσότερα »

Tbo-filgrastim, a short-acting human granulocyte colony-stimulating factor

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα

Clinical safety of AbstractThe recombinant human granulocyte colony-stimulating factor (G-CSF) known as filgrastim (Tevagrastim®, Ratiograstim®, Biograstim®) in Europe (approved in 2008) and tbo-filgrastim (Granix®) in the USA (approved in 2012; Teva Pharmaceutical Industries Ltd., Petach Tikva, Israel) is indicated to reduce the duration of severe neutropenia in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia. This article presents pooled clinical data for tbo-filgrastim c... περισσότερα »

20- versus 45-min post-infusion scalp cooling time in the prevention of docetaxel-induced alopecia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 47 δευτερόλεπτα

Results of Abstract PurposeFor patients, chemotherapy-induced alopecia (CIA) is one of the most distressing side effects of treatment. Scalp cooling can prevent or minimise CIA; the results may depend on the duration of cooling. Since a previous study on post-infusion cooling time in patients treated with docetaxel chemotherapy found no difference between 90 and 45 min, we investigated whether hair-preserving results could be maintained with a shorter post-infusion cooling time. MethodsIn this prospective, multi-centre randomised study, 134 patients who started treatment with ... περισσότερα »

Dietary intake variability in the cycle of cytotoxic chemotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 47 δευτερόλεπτα

Dietary intake variability in the cycle of cytotoxic chemotherapy: Abstract PurposeThis study was conducted to evaluate the dietary intake at different time points of the chemotherapeutic cycle. MethodsFifty-five ovarian cancer patients receiving at least 2 cycles of chemotherapy were deemed eligible for this study, of which 41 participants completed the study. Anthropometrical measurements and Subjective Global Assessment were used to estimate nutritional status. The dietary intake was evaluated by 3-day food records: 3 days prior to, the day of, and the following day after che... περισσότερα »

Margin Status in Shave Biopsies of Nonmelanoma Skin Cancers: Is It Worth Reporting?

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα

*Margin Status in Shave Biopsies of Nonmelanoma Skin Cancers: Is It Worth Reporting?* Arch Pathol Lab Med. 2016 Apr 26; Authors: Schnebelen AM, Gardner JM, Shalin SC Abstract Context .- The practice of reporting margin status in biopsies is relatively unique to biopsies of the skin and highly variable among pathologists. Objective .- To address the accuracy of margin evaluation in shave biopsies of nonmelanoma skin cancers. Design .- We collected shave biopsies of squamous and basal cell carcinomas that appeared to have uninvolved margins on routine sign out. We obtained deeper l... περισσότερα »

Estrogen Receptor and Cytokeratin 5 Are Reliable Markers to Separate Usual Ductal Hyperplasia From Atypical Ductal Hyperplasia and Low-Grade Ductal Carcinoma In Situ.

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα

*Estrogen Receptor and Cytokeratin 5 Are Reliable Markers to Separate Usual Ductal Hyperplasia From Atypical Ductal Hyperplasia and Low-Grade Ductal Carcinoma In Situ.* Arch Pathol Lab Med. 2016 Apr 26; Authors: Martinez AP, Cohen C, Hanley KZ, Li XB Abstract Context .- High-molecular weight cytokeratins, such as cytokeratin 5 (CK5), are helpful to distinguish usual ductal hyperplasia (UDH) from atypical ductal hyperplasia (ADH) or low-grade ductal carcinoma in situ (DCIS). Few studies have looked at combining CK5 with estrogen receptor (ER) to differentiate UDH from ADH. OBJECTI...περισσότερα »

Educational Value of Digital Whole Slides Accompanying Published Online Pathology Journal Articles: A Multi-Institutional Study.

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα

*Educational Value of Digital Whole Slides Accompanying Published Online Pathology Journal Articles: A Multi-Institutional Study.* Arch Pathol Lab Med. 2016 Apr 26; Authors: Yin F, Han G, Bui MM, Gibbs J, Martin I, Sundharkrishnan L, King L, Jabcuga C, Stuart LN, Hassell LA Abstract Context .- Despitep pgreat interest in using whole slide imaging (WSI) in pathology practice and education, few pathology journals have published WSI pertinent to articles within their pages or as supplemental materials. Objective .- To evaluate whether there is measurable added educational value of i... περισσότερα »

Crizotinib improves intracranial metastasis control

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα

[News] A randomised phase 3 trial has shown improved efficacy of crizotinib to treat ALK-positive, non-small-cell lung cancer brain metastases compared with chemotherapy (pemetrexed-cisplatin or pemetrexed-carboplatin). In the study by Solomon and colleagues of 79 patients with treated brain metastases, at 12 weeks, the proportion of patients that achieved intracranial disease control was 85% (95% CI 70–94%) compared with 45% (29–62%; p<0·001). At 24 weeks, the proportion of patients that achieved intracranial disease control was 56% (95% CI 40–72%) in patients treated with criz...περισσότερα »

Proton therapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα

[Comment] Beyond a moonshot: insurance coverage for proton therapy: [image: main.pdf.png] Health care in the USA is undergoing fundamental transformation. Implementation of the Patient Protection and Affordable Care Act and ensuing Federal legislative efforts are changing the way cutting-edge scientific innovations are translated to outcomes in patients. At the same time, oncology therapy is advancing rapidly (eg, precision medicine, targeted therapies, and robotic surgery), as is radiotherapy technology (eg, stereotactic body radiotherapy, novel imaging and treatment delivery ... περισσότερα »

Nominal nomograms and marginal margins

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα

what is the law of the line?: [image: main.pdf.png] Derived from ancient Greek, nomogram translates to “law of the line”, which is a laconic translation that can be heeded when using a nomogram. Broadly speaking, how and when should these so-called laws be applied? In this issue of The Lancet Oncology, Dario Callegaro and colleagues1 developed two nomograms to predict 10-year overall survival and development of distal metastasis in localised extremity, soft-tissue sarcomas.

Procalcitonin-guided protocol is not useful to manage antibiotic therapy in febrile neutropenia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα

a randomized controlled trial: AbstractFebrile neutropenia (FN) requires immediate use of antibiotics (ATB), and procalcitonin (PCT) is proven to be useful in guiding antibiotic therapy in different settings. This study investigated the use of PCT as a guide for the duration of ATB in FN. A randomized controlled trial was carried out from January–December 2010. A total of 62 hematological adult patients with FN were randomized, in 1:1 ratio, into two groups: (1) PCT group: length of ATB guided by institutional protocol plus PCT dynamics, and (2) control group: duration of ATB in ac... περισσότερα »

Marizomib in Advanced Malignancies including MM

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα

Marizomib in Advanced Malignancies including MM: Purpose: Marizomib (NPI-0052) is an irreversible proteasome inhibitor, derived from a marine actinomycete, with activity and specificity that is distinct from other proteasome inhibitors. Experimental Design: Phase 1 study (NPI-0052-102) evaluated the maximum-tolerated dose, pharmacokinetics, and pharmacodynamics of marizomib intravenously on two dosing schedules. Results: Forty-two patients with advanced malignancies received Schedule A (0.1 to 0.9 mg/m2 over 1-10 minutes on Days 1, 8, 15 in 4-week cycles); 44 patients with relapsed... περισσότερα »

Mucostomy closure using the endoloop/clips technique in a purse-string manner after an unsuccessful closure during peroral endoscopic myotomy.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Related Articles Mucostomy closure using the endoloop/clips technique in a purse-string manner after an unsuccessful closure during peroral endoscopic myotomy. Dig Endosc. 2015 Jul;27(5):630-1 Authors: Shiwaku H, Inoue H, Yamashita Y PMID: 25912050 [PubMed – indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1TdtcvK via IFTTT from #Med Blogs by… Continue reading Mucostomy closure using the endoloop/clips technique in a purse-string manner after an unsuccessful closure during peroral endoscopic myotomy.

Esophageal perforation, inflammatory mediastinitis and pseudoaneurysm of the thoracic aorta as potential complications of botulinum toxin injection for achalasia.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Related Articles Esophageal perforation, inflammatory mediastinitis and pseudoaneurysm of the thoracic aorta as potential complications of botulinum toxin injection for achalasia. Dig Endosc. 2015 Jul;27(5):618-21 Authors: Chao CY, Raj A, Saad N, Hourigan L, Holtmann G Abstract Primary achalasia is a motility disorder of the esophagus involving impaired relaxation of the esophageal sphincter and, in… Continue reading Esophageal perforation, inflammatory mediastinitis and pseudoaneurysm of the thoracic aorta as potential complications of botulinum toxin injection for achalasia.

Number of Gastrointestinal Symptoms is a Useful Means of Identifying Patients with Cancer for Dysphagia.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Number of Gastrointestinal Symptoms is a Useful Means of Identifying Patients with Cancer for Dysphagia. Dysphagia. 2016 Apr 26; Authors: Tsukamoto M, Manabe N, Kamada T, Hirai T, Hata J, Haruma K, Inoue K Abstract Dysphagia is a symptom suggestive of severe underlying pathology, although its causes include organic and non-organic disorders. The epidemiology of… Continue reading Number of Gastrointestinal Symptoms is a Useful Means of Identifying Patients with Cancer for Dysphagia.

Substantial variability in biopsy practice patterns among gastroenterologists for suspected eosinophilic gastrointestinal disorders.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Substantial variability in biopsy practice patterns among gastroenterologists for suspected eosinophilic gastrointestinal disorders. Clin Gastroenterol Hepatol. 2016 Apr 22; Authors: Dellon ES, Collins MH, Bonis PA, Capocelli KE, Dohil R, Falk GW, Furuta GT, Gupta SK, Hirano I, Hiremath GS, Kagalwalla AF, Leung J, Liacouras CA, Menard-Katcher C, Muir AB, Mukkada VA, Putnam PE, Schoepfer… Continue reading Substantial variability in biopsy practice patterns among gastroenterologists for suspected eosinophilic gastrointestinal disorders.

Noncosmetic uses of botulinum toxin in otolaryngology.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Related Articles Noncosmetic uses of botulinum toxin in otolaryngology. Cleve Clin J Med. 2015 Nov;82(11):729-32 Authors: Benninger MS, Smith LJ Abstract Botulinum toxin has several noncosmetic uses in otolaryngology. It is the primary treatment for spasmodic dysphonia and may be effective in select patients who have essential tremor of the voice. It may also be… Continue reading Noncosmetic uses of botulinum toxin in otolaryngology.

Laryngopharyngeal reflux COPD to uncover reflux and columnar lined esophagus.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Related Articles Laryngopharyngeal reflux COPD to uncover reflux and columnar lined esophagus. Int J Chron Obstruct Pulmon Dis. 2015;10:2095-6 Authors: Kristo I, Riegler M, Schoppmann SF PMID: 26457051 [PubMed – indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1TdtcMj via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis… Continue reading Laryngopharyngeal reflux COPD to uncover reflux and columnar lined esophagus.

Expansion of a Discrete 3 × 3 Mn9 Metallogrid to a µ-Carboxylato-Bridged Polymeric {Mn11}n Assembly

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Abstract Compounds based on the [3 × 3] nonamanganese(II) square grid motif and featuring additional manganese(II) ions linked to the grid core were isolated through a strict self-assembly approach. Extended tritopic picolinic dihydrazide ligands were used, which contain terminal ester groups and differ in the R substituent on the para position of the central pyridine ring (H2L1,… Continue reading Expansion of a Discrete 3 × 3 Mn9 Metallogrid to a µ-Carboxylato-Bridged Polymeric {Mn11}n Assembly

Successful surgical management of a rare esophageal inflammatory myofibroblastic tumour: a case report.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Related Articles Successful surgical management of a rare esophageal inflammatory myofibroblastic tumour: a case report. J Cardiothorac Surg. 2015;10:112 Authors: Khakural P, Sapkota R, Shrestha UK, Sayami P Abstract Inflammatory myofibroblastic tumour (IMT) is an uncommon mesenchymal tumour, which can occur anywhere in the body, rarely in esophagus. Mostly, the diagnosis is postoperative, after the… Continue reading Successful surgical management of a rare esophageal inflammatory myofibroblastic tumour: a case report.

Polar Liquid Crystals Derived from Sulfonium Zwitterions of the closo-1-CB11H12– Anion

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Abstract A series of substituted 12-sulfonium zwitterions 1[n] and one example of a 1-sulfonium analogue 2[5]a were prepared in four steps. Derivatives 1[n] exhibit rich crystalline polymorphism and a high-temperature SmBcry phase stabilized by dipolar interactions. Solution studies in a nematic host demonstrated positive dielectric anisotropy of compounds 1[5]a–1[5]c (Δϵ ≈ +18 extrapolated from 8… Continue reading Polar Liquid Crystals Derived from Sulfonium Zwitterions of the closo-1-CB11H12– Anion

Highly DNA-Photoreactive Ruthenium 1,4,5,8-Tetraazaphenanthrene Complex Conjugated to the TAT Peptide: Efficient Vectorization inside HeLa Cells without Phototoxicity – The Importance of Cellular Distribution

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 53 δευτερόλεπτα

Abstract The photoreactive [Ru(TAP)2(phen)]2+ (TAP = 1,4,5,8-tetraazaphenanthrene; phen = 1,10-phenanthroline) complex tethered to the cell-penetrating peptide (CPP) TAT was studied in vitro and in cellulo. The tethering of the complex does not affect its behavior under blue-light irradiation in the presence of guanine-containing oligodeoxyribonucleotides (ODNG). Thus, the luminescence is quenched in the presence of ODNG,… Continue reading Highly DNA-Photoreactive Ruthenium 1,4,5,8-Tetraazaphenanthrene Complex Conjugated to the TAT Peptide: Efficient Vectorization inside HeLa Cells... περισσότερα »

Anticlastogenicity and Anticarcinogenicity of Purple Rice Extract

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα

in Rats.: Nutr Cancer. 2016 Apr 26;:1-8 Authors: Punvittayagul C, Sankam P, Taya S, Wongpoomchai R Abstract Oryza sativa L. var. indica cv. Kum Doi Saket is a pigmented rice variety grown in northern Thailand. Our previous study found that the methanol extract of purple rice seed had the highest level of antimutagenicity in a Salmonella mutation assay. The present study was designed to evaluate its in vivo anticlastogenic and anticarcinogenic potentials. The purple rice extract had no acute toxicity on rats. The oral administration of 1,000 mg/kg body weight (bw) of the extract f... περισσότερα »

Meta-Analysis Comparing Zero-Profile Spacer and Anterior Plate in Anterior Cervical Fusion.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 56 δευτερόλεπτα

[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Meta-Analysis Comparing Zero-Profile Spacer and Anterior Plate in Anterior Cervical Fusion.* PLoS One. 2015;10(6):e0130223 Authors: Dong J, Lu M, Lu T, Liang B, Xu J, Zhou J, Lv H, Qin J, Cai X, Huang S, Li H, Wang D, He X Abstract BACKGROUND: Anterior plate fusion is an effective procedure for the treatment of cervical spinal diseases but is accompanied by a high incidence of postoperative dysphagia. A zero profile (Zero-P) spacer is increasingly being used to reduce postoperative dysp... περισσότερα »

Mucostomy closure using the endoloop/clips technique in a purse-string manner after an unsuccessful closure during peroral endoscopic myotomy.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 56 δευτερόλεπτα

[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Mucostomy closure using the endoloop/clips technique in a purse-string manner after an unsuccessful closure during peroral endoscopic myotomy.* Dig Endosc. 2015 Jul;27(5):630-1 Authors: Shiwaku H, Inoue H, Yamashita Y PMID: 25912050 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1TdtcvK via IFTTT

Esophageal perforation, inflammatory mediastinitis and pseudoaneurysm of the thoracic aorta as potential complications of botulinum toxin injection for achalasia.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 56 δευτερόλεπτα

[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Esophageal perforation, inflammatory mediastinitis and pseudoaneurysm of the thoracic aorta as potential complications of botulinum toxin injection for achalasia.* Dig Endosc. 2015 Jul;27(5):618-21 Authors: Chao CY, Raj A, Saad N, Hourigan L, Holtmann G Abstract Primary achalasia is a motility disorder of the esophagus involving impaired relaxation of the esophageal sphincter and, in later stages, dilatation and aperistalsis of the tubular esophagus. Endoscopic botulinum toxin injection to the lower esophageal sp... περισσότερα »

Letter to the Editor. Older Adults’ Experiences of Living with Cleft Lip and Palate: A Qualitative Study Exploring Ageing and Appearance.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα

Letter to the Editor. Older Adults’ Experiences of Living with Cleft Lip and Palate: A Qualitative Study Exploring Ageing and Appearance. Cleft Palate Craniofac J. 2016 Apr 26; Authors: Hamlet C, Harcourt D PMID: 27115563 [PubMed – as supplied by publisher] from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SrMS2E via IFTTT

Interferon Regulatory Factor 6 Controls Proliferation of Keratinocytes From Children With Van der Woude Syndrome.

Interferon Regulatory Factor 6 Controls Proliferation of Keratinocytes From Children With Van der Woude Syndrome. Cleft Palate Craniofac J. 2016 Apr 26; Authors: Hixon K, Rhea L, Standley J, Canady FJ, Canady JW, Dunnwald M Abstract OBJECTIVE: Interferon Regulatory Factor 6 (IRF6) is critical for craniofacial development, epidermal differentiation, and tissue repair. IRF6 mutations cause […]

Maxillary Anterior Segmental Distraction Osteogenesis to Correct Maxillary Deficiencies in a Patient With Cleft Lip and Palate.

Maxillary Anterior Segmental Distraction Osteogenesis to Correct Maxillary Deficiencies in a Patient With Cleft Lip and Palate. Cleft Palate Craniofac J. 2016 Apr 26; Authors: Kageyama-Iwata A, Haraguchi S, Iida S, Aikawa T, Yamashiro T Abstract This report describes a case of successful orthodontic treatment using maxillary anterior segmental distraction osteogenesis with an internal maxillary […]

Allergy-Free Peanuts? Not So Fast

CRISPR technology is being touted as a way to remove this ubiquitous food’s deadly potential, but it won’t be easy—if it’s possible at all

Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats

The purpose of this study was to investigate the antioxidant and anti-inflammatory effects of the combined extract of Rhei rhizoma and Coptidis rhizoma (RC-mix) in experimental model of acute reflux esophagitis. The antioxidant activity was assessed by in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. RC-mix was given at 100, 200, and 400 mg/kg body […]

Influences of the Cloud Shape of Fuel-Air Mixtures on the Overpressure Field

This paper presents an experiment system in the open field, which comprises a charge structure (approximately 166.2 kg), a high-speed camera subsystem, and a pressure measurement subsystem. Through a series of experiments under the cylindrical clouds with different diameters, heights, and diameter-to-height ratios ( : ), the influences of various cloud shapes on the overpressure field were analyzed […]

Unmet Supportive Care Needs among Breast Cancer Survivors of Community-Based Support Group in Kuching, Sarawak

Background. Recognizing the needs of cancer survivors is one of the important aspects in healthcare delivery. This study aimed to determine the prevalence of unmet supportive care needs and its associated factors among the breast cancer survivors of community-based support group in Kuching, Sarawak. Materials and Methods. This was a cross-sectional study using Supportive Care […]

Glowworm Swarm Optimization and Its Application to Blind Signal Separation

Traditional optimization algorithms for blind signal separation (BSS) are mainly based on the gradient, which requires the objective function to be continuous and differentiable, so the applications of these algorithms are very limited. Moreover, these algorithms have problems with the convergence speed and accuracy. To overcome these drawbacks, this paper presents a modified glowworm swarm […]

Comparison of the Early Clinical Outcomes between Combined Small-Incision Lenticule Extraction and Collagen Cross-Linking versus SMILE for Myopia

Background. To compare the early outcome of combined SMILE and collagen crosslinking (SMILE Xtra) with SMILE. Method. Prospective, comparative interventional study of 21 eyes receiving SMILE Xtra using a low energy protocol and 32 control eyes receiving SMILE only. The outcomes were compared at 1, 3, and 6 months postoperatively. Results. Both groups had myopia […]

Detecting the Intention to Move Upper Limbs from Electroencephalographic Brain Signals

Early decoding of motor states directly from the brain activity is essential to develop brain-machine interfaces (BMI) for natural motor control of neuroprosthetic devices. Hence, this study aimed to investigate the detection of movement information before the actual movement occurs. This information piece could be useful to provide early control signals to drive BMI-based rehabilitation […]

The Effect of Decreased Audibility on MMSE Performance: A Measure Commonly Used for Diagnosing Dementia.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 59 δευτερόλεπτα

*The Effect of Decreased Audibility on MMSE Performance: A Measure Commonly Used for Diagnosing Dementia.* J Am Acad Audiol. 2016 Apr;27(4):311-323 Authors: Jorgensen LE, Palmer CV, Pratt S, Erickson KI, Moncrieff D Abstract BACKGROUND: Hearing loss and dementia are both prevalent in late adulthood. The most common test used to determine cognitive status in late adulthood, the Mini-Mental State Examination (MMSE), is presented face to face, usually in the context of the physician's office in the presence of background noise. Despite the problems of hearing loss and cognitive prob... περισσότερα »

Antibody Responses After Primary Immunization in Infants Born to Women Receiving a Pertussis-containing Vaccine During Pregnancy: Single Arm Observational Study With a Historical Comparator

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 59 δευτερόλεπτα

from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1SJGSBi via IFTTT

Intranasal application of polyethyleneimine suppresses influenza virus infection in mice

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 59 δευτερόλεπτα

*Intranasal application of polyethyleneimine suppresses influenza virus infection in mice* Emerging Microbes & Infections 5, e41 (April 2016). doi:10.1038/emi.2016.64 Authors: Biao He, Yuhong Fu, Shuai Xia, Fei Yu, Qian Wang, Lu Lu & Shibo Jiang from Infection via ola Kala on Inoreader http://ift.tt/1rhlmLf via IFTTT

Margin Status in Shave Biopsies of Nonmelanoma Skin Cancers: Is It Worth Reporting?

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

Estrogen Receptor and Cytokeratin 5 Are Reliable Markers to Separate Usual Ductal Hyperplasia From Atypical Ductal Hyperplasia and Low-Grade Ductal Carcinoma In Situ.

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

Educational Value of Digital Whole Slides Accompanying Published Online Pathology Journal Articles: A Multi-Institutional Study.

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-γ-linolenic acid and enhances the effica cy of chemotherapy in colon cancer cells expressing COX-2

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Publication date: July 2016 Source:Free Radical Biology and Medicine, Volume 96 Author(s): Yi Xu, Xiaoyu Yang, Pinjing Zhao, Zhongyu Yang, Changhui Yan, Bin Guo, Steven Y. Qian Cyclooxygenase (COX), commonly overexpressed in cancer cells, is a major lipid peroxidizing enzyme that metabolizes polyunsaturated fatty acids (ω-3s and ω-6s). The COX-catalyzed free radical peroxidation of arachidonic […]

Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Publication date: July 2016 Source:Free Radical Biology and Medicine, Volume 96 Author(s): Viktor M. Pastukh, Olena M. Gorodnya, Mark N. Gillespie, Mykhaylo V. Ruchko Mitochondria of mammalian cells contain multiple copies of mitochondrial (mt) DNA. Although mtDNA copy number can fluctuate dramatically depending on physiological and pathophysiologic conditions, the mechanisms regulating mitochondrial genome replication remain […]

Admissions for isolated non-operative mild head injuries: Sharing the burden among trauma surgery, neurosurgery, and neurology.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Admissions for isolated non-operative mild head injuries: Sharing the burden among trauma surgery, neurosurgery, and neurology. J Trauma Acute Care Surg. 2016 Apr 26; Authors: Zhao T, Mejaddam AY, Chang Y, DeMoya MA, King DR, Yeh DD, Kaafarani HM, Alam HB, Velmahos GC Abstract BACKGROUND: Isolated non-operative mild head injuries (INOMHI) occur with increasing frequency […]

Sinus surgery postpones chronic Gram-negative lung infection: cohort study of 106 patients with cystic fibrosis.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Sinus surgery postpones chronic Gram-negative lung infection: cohort study of 106 patients with cystic fibrosis. Rhinology. 2016 Apr 26; Authors: Alanin MC, Aanaes K, Høiby N, Pressler T, Skov M, Nielsen KG, Taylor-Robinson D, Waldmann E, Krogh Johansen H, von Buchwald C Abstract BACKGROUND: In patients with cystic fibrosis (CF) the sinuses are a bacterial […]

Non-AIDS Defining Cancer Mortality: Emerging Patterns in the Late HAART Era.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Non-AIDS Defining Cancer Mortality: Emerging Patterns in the Late HAART Era. J Acquir Immune Defic Syndr. 2016 Apr 21; Authors: Zucchetto A, Virdone S, Taborelli M, Grande E, Camoni L, Pappagallo M, Regine V, Grippo F, Polesel J, Dal Maso L, Suligoi B, Frova L, Serraino D Abstract BACKGROUND: Non-AIDS defining cancers (non-ADCs) have become […]

Junctional Adhesion Molecule-A in Head and Neck Squamous Cell Carcinoma.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Junctional Adhesion Molecule-A in Head and Neck Squamous Cell Carcinoma. Adv Otorhinolaryngol. 2016 Apr 26;77:92-97 Authors: Kurose M, Kakuki T, Takano K, Kondo A, Obata K, Nomura K, Miyata R, Kaneko Y, Konno T, Kohno T, Kojima T, Himi T Abstract Junctional adhesion molecule-A (JAM-A), which belongs to the IgG superfamily, is one of the […]

Hearing Aid Patient Education Materials: Is There Room for Improvement?

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Hearing Aid Patient Education Materials: Is There Room for Improvement? J Am Acad Audiol. 2016 Apr;27(4):354-359 Authors: Joseph J, Svider PF, Shaigany K, Eloy JA, McDonald PG, Folbe AJ, Hong RS Abstract PURPOSE: The purpose of this study was to analyze and compare the readability of patient education materials (PEMs) from leading manufacturers of behind-the-ear […]

Changes in urinary Cu, Zn, and Se levels in cancer patients after treatment with Sha Shen Mai Men Dong Tang.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Changes in urinary Cu, Zn, and Se levels in cancer patients after treatment with Sha Shen Mai Men Dong Tang. J Tradit Complement Med. 2016 Apr;6(2):135-9 Authors: Lai TY, Kuo HW Abstract Sha Shen Mai Men Dong Tang (SMD-2; shā shēn mài dōng tāng) is a Chinese medicinal herb (CMH; zhōng cǎo yào) used to […]

Aortic Complex Plaque Predicts the Risk of Cryptogenic Ischemic Cerebrovascular Disease Recurrence.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Aortic Complex Plaque Predicts the Risk of Cryptogenic Ischemic Cerebrovascular Disease Recurrence. Aging Dis. 2016 Mar;7(2):114-20 Authors: Dong J, Ma X, Qie J, Ji X Abstract To evaluate the correlations between aortic complex plaque (ACP) and the recurrence of cryptogenic ischemic cerebrovascular disease (CICVD), and to investigate the clinical significance of ACP in CICVD. Methods […]

Rarely Seen Nasal Congenital Problems Causing Neonatal Upper Respiratory Obstruction: A Case Series.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Rarely Seen Nasal Congenital Problems Causing Neonatal Upper Respiratory Obstruction: A Case Series. Pediatr Rep. 2016 Mar 31;8(1):6456 Authors: Başal Y, Akcan AB, Polat YD, Günel C, Eryilmaz A, Başak S Abstract Since newborns are obligatory nasal breathers, upper respiratory tract problems may sometimes be life threatening. The most common pathology causing dyspnea and stridor […]

Dynamics and Predictors of Serum TSH and fT4 Reference Limits in Early Pregnancy. A Study within the Danish National Birth Cohort.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Dynamics and Predictors of Serum TSH and fT4 Reference Limits in Early Pregnancy. A Study within the Danish National Birth Cohort.* J Clin Endocrinol Metab. 2016 Apr 26;:jc20161387 Authors: Laurberg P, Andersenet SL, Hindersson P, Nohr EA, Olsen J Abstract CONTEXT: Thyroid hormones are important developmental factors and levels should be adequate both in the pregnant woman and in the fetus. However, there is no consensus on maternal thyroid test reference limits in early pregnancy. OBJECTIVE: Estimation of week-to-week changes in and predictors of TSH and fT4 reference limits in ...περισσότερα »

Calcium sensing receptor tumor expression and lethal prostate cancer progression.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Calcium sensing receptor tumor expression and lethal prostate cancer progression.* J Clin Endocrinol Metab. 2016 Apr 26;:jc20161082 Authors: Ahearn TU, Tchrakian N, Wilson KM, Lis R, Nuttall E, Sesso HD, Loda M, Giovannucci E, Mucci LA, Finn S, Shui IM Abstract CONTEXT: Prostate cancer metastases preferentially target bone and the calcium sensing receptor (CaSR) may play a role in promoting this metastatic progression. OBJECTIVE: We evaluated the association of prostate tumor CaSR expression with lethal prostate cancer. DESIGN: A validated CaSR immunohistochemistry (IHC) assay wa... περισσότερα »

Imaging Outcomes of Liver Imaging Reporting and Data System Version 2014 Category 2, 3, and 4 Observations Detected at CT and MR Imaging.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Imaging Outcomes of Liver Imaging Reporting and Data System Version 2014 Category 2, 3, and 4 Observations Detected at CT and MR Imaging.* Radiology. 2016 Apr 26;:152173 Authors: Tanabe M, Kanki A, Wolfson T, Costa EA, Mamidipalli A, Ferreira MP, Santillan C, Middleton MS, Gamst AC, Kono Y, Kuo A, Sirlin CB Abstract Purpose To determine the proportion of untreated Liver Imaging Reporting and Data System (LI-RADS) version 2014 category 2, 3, and 4 observations that progress, remain stable, or decrease in category and to compare the cumulative incidence of progression in category. ... περισσότερα »

Mass-forming Intrahepatic Cholangiocarcinoma: Diffusion-weighted Imaging as a Preoperative Prognostic Marker.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Mass-forming Intrahepatic Cholangiocarcinoma: Diffusion-weighted Imaging as a Preoperative Prognostic Marker.* Radiology. 2016 Apr 26;:151781 Authors: Lee J, Kim SH, Kang TW, Song KD, Choi D, Jang KT Abstract Purpose To assess the value of diffusion-weighted (DW) imaging as a prognostic marker in preoperative evaluation of patients with mass-forming intrahepatic cholangiocarcinoma (ICC). Materials and Methods This retrospective study was approved by the institutional review board, and the informed consent requirement was waived. A total of 91 patients who underwent hepatic resec... περισσότερα »

Use of endocrinological and neurological medication among 5-year survivors of young onset brain tumors.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα

*Use of endocrinological and neurological medication among 5-year survivors of young onset brain tumors.* J Neurooncol. 2016 Apr 26; Authors: Gunn ME, Lähdesmäki T, Malila N, Arola M, Grönroos M, Matomäki J, Lähteenmäki PM Abstract The burden of late-effects for young onset brain tumor (BT) survivors needs more careful evaluation. Our aim was to assess the need for endocrinological and neurological medication among this specific group. We identified 5-year survivors diagnosed at the age of 0-24 years between 1988 and 2004 from the Finnish Cancer Registry (N = 602). Data on endoc...περισσότερα »

A Clinical Review of Thyroid Cancer at Sapporo Medical University Hospital.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα

*A Clinical Review of Thyroid Cancer at Sapporo Medical University Hospital.* Adv Otorhinolaryngol. 2016 Apr 26;77:88-91 Authors: Koizumi J, Takano K, Obata K, Yamamoto K, Murayama K, Himi T Abstract Thyroid cancer is a disease that affects 8,000 new individuals a year, a number that has increased approximately 3-fold in the past 30 years. The increase in the incidence of thyroid cancer can be related to various factors. The evolution of diagnostic technology has distinctly occurred in the fields of diagnostic imaging, cytology and immunochemistry. For example, liquid-based cytol... περισσότερα »

Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα

*Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding.* Proc Natl Acad Sci U S A. 2016 Apr 25; Authors: Wei X, Wu S, Song T, Chen L, Gao M, Borcherds W, Daughdrill GW, Chen J Abstract The MDMX oncoprotein is an important regulator of tumor suppressor p53 activity during embryonic development. Despite sequence homology to the ubiquitin E3 ligase MDM2, MDMX depletion activates p53 without significant increase in p53 level, implicating a degradation-independent mechanism. We present evidence that MDMX inhibits the sequence-specific DNA binding activity of... περισσότερα »

Metastatic large cell neuroendocrine carcinoma of the lung arising from the uterus: A pitfall in lung cancer diagnosis.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα

*Metastatic large cell neuroendocrine carcinoma of the lung arising from the uterus: A pitfall in lung cancer diagnosis.* Pathol Res Pract. 2016 Apr 2; Authors: Ono K, Yokota NR, Yoshioka E, Noguchi A, Washimi K, Kawachi K, Miyagi Y, Kato H, Yokose T Abstract A 41-year-old female smoker presented with a vaginal mass. Gynecological examination showed a mass filling the uterine corpus, cervix, and vagina. A total abdominal hysterectomy was performed. Macroscopic findings included a large fragile mass involving the uterine cavity, cervix, and vagina. Histology revealed atypical duct... περισσότερα »

Thyroid carcinoma with rhabdoid phenotype: Case report with review of the literature.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα

Branchial cleft-like cysts in Hashimoto's thyroiditis: A case report and literature review.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα

[Study on the hemodynamic changes in solid thyroid nodules by ultrasound contrast quantitative analysis].

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα

microRNA-762 promotes breast cancer cell proliferation and invasion by targeting IRF7 expression.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα

Related Articles *microRNA-762 promotes breast cancer cell proliferation and invasion by targeting IRF7 expression.* Cell Prolif. 2015 Dec;48(6):643-9 Authors: Li Y, Huang R, Wang L, Hao J, Zhang Q, Ling R, Yun J Abstract OBJECTIVES: miRNAs play crucial roles in human tumourigenesis. This study was performed to measure expression and function of miR-762 in breast cancer. MATERIALS AND METHODS: Expression of miR-762 in breast tissues and cell lines (SK-BR-3, DA-MB-435s, MCF-7 and MDA-MB-231, HBL-100) was measured by using real-time RT-PCR. We restored expression of miR-762 in MCF-...περισσότερα »

SUVmax of 18F-FDG PET/CT in the differential diagnosis of benign and malignant thyroid nodules according to tumor volume.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα

Related Articles *SUVmax of 18F-FDG PET/CT in the differential diagnosis of benign and malignant thyroid nodules according to tumor volume.* World J Surg Oncol. 2015;13:217 Authors: Kim TH, Ji YB, Song CM, Kim JY, Choi YY, Park JS, Tae K Abstract BACKGROUND: The aim of this study was to investigate whether the maximum standardized uptake value (SUVmax) measured on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) could be used as the primary means of differential diagnosis of thyroid nodules when tumor volume is assessed. METHODS: We...περισσότερα »

Computerized analysis of calcification of thyroid nodules as visualized by ultrasonography.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα

Related Articles *Computerized analysis of calcification of thyroid nodules as visualized by ultrasonography.* Eur J Radiol. 2015 Oct;84(10):1949-53 Authors: Choi WJ, Park JS, Kim KG, Kim SY, Koo HR, Lee YJ Abstract OBJECTIVE: The purpose of this study is to quantify computerized calcification features from ultrasonography (US) images of thyroid nodules in order to determine the ability to differentiate between malignant and benign thyroid nodules. METHODS: We designed and implemented a computerized analysis scheme to quantitatively analyze the US features of the calcified thyroi... περισσότερα »

Improving the approach to non-diagnostic aspirates: learning from each other.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα

Related Articles *Improving the approach to non-diagnostic aspirates: learning from each other.* Endocrine. 2015 Aug;49(3):575-6 Authors: Alexander EK PMID: 25837308 [PubMed - indexed for MEDLINE] from pubmed: thyroid cancer http://ift.tt/1Nzhqzr via IFTTT

Sleep spindles during a nap correlate with post sleep memory performance for highly rewarded word-pairs

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

Nicotinamide Mononucleotide Adenylyl Transferase 2: A Promising Diagnostic and Therapeutic Target for Colorectal Cancer

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα

Colorectal cancer (CRC) is one of the most common cancers all over the world. It is essential to search for more effective diagnostic and therapeutic methods for CRC. Abnormal nicotinamide adenine dinucleotide (NAD) metabolism has been considered as a characteristic of cancer cells. In this study, nicotinamide mononucleotide adenylyl transferases (NMNATs) as well as p53-mediated cancer signaling pathways were investigated in patients with colorectal cancer. The CRC tissues and adjacent normal tissues were obtained from 95 untreated colorectal cancer patients and were stained for e...περισσότερα »

A Weinreb Amide Based Building Block for Convenient Access to β,β-Diarylacroleins: Synthesis of 3-Arylindanones

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα

Abstract Towards the synthesis of symmetrical and unsymmetrical β,β-diarylacroleins for assembling diarylmethine fragments present in biologically important molecules, we have developed a new Weinreb amide (WA) based building block, derived from propiolic acid. The WA functionality present in this compound allowed the sequential addition of various arylmagnesium bromide reagents in a controlled manner. The developed methodology for the access to β,β-diarylacroleins has been utilised for the synthesis of biologically important 3-arylindanone molecules. [image: Thumbnail image of gra...περισσότερα »

Synthesis and Catalytic Activity of Gold Nanoparticles Supported on Dendrimeric Nanocellulose Hybrids

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα

Abstract Thanks to their unique properties, such as (i) renewability, (ii) high aspect ratios, (iii) low density, (iv) biodegradability, (v) high strength, and (vi) stiffness, there have been many reports in recent years detailing the isolation and functionalization of cellulose nanowhiskers from cellulose. Moreover, nanocellulose can be produced in large quantities in a cost-effective manner and can be easily functionalized due to its high density of hydroxy groups. In the present work, alkynyl-dendrons of the PAMAM family were covalently attached to azide-functionalized cellulose... περισσότερα »

A General and Mild Copper(I)-Catalyzed Three-Component Reaction of Cyanamides, Amines, and Diaryliodonium Triflates

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα

Abstract A highly efficient copper-catalyzed three-component reaction of cyanamides, amines, and diaryliodonium triflates was developed for the synthesis of guanidines. The mild reaction accommodates both aromatic and aliphatic amines and provides the products in good yields with good functional group tolerance. Moreover, it was demonstrated that C–H activation of the arenes could be realized for the direct preparation of guanidines. [image: Thumbnail image of graphical abstract] A Cu-catalyzed three-component reaction of cyanamides, amines, and diaryliodoniums is established for ... περισσότερα »

Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 1 ώρα

Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 1 ώρα

Successful surgical management of a rare esophageal inflammatory myofibroblastic tumour: a case report.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 1 ώρα

Related Articles *Successful surgical management of a rare esophageal inflammatory myofibroblastic tumour: a case report.* J Cardiothorac Surg. 2015;10:112 Authors: Khakural P, Sapkota R, Shrestha UK, Sayami P Abstract Inflammatory myofibroblastic tumour (IMT) is an uncommon mesenchymal tumour, which can occur anywhere in the body, rarely in esophagus. Mostly, the diagnosis is postoperative, after the hispathological evaluation of the specimen. There are no definite guidelines regarding the diagnosis and management. Here, we report a 60 year old lady presenting with dysphagia, d... περισσότερα »

Core temperature affects scalp skin temperature during scalp cooling.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 1 ώρα

Related Articles *Core temperature affects scalp skin temperature during scalp cooling.* Int J Dermatol. 2015 Aug;54(8):916-21 Authors: Daanen HA, Peerbooms M, van den Hurk CJ, van Os B, Levels K, Teunissen LP, Breed WP Abstract BACKGROUND: The efficacy of hair loss prevention by scalp cooling to prevent chemotherapy induced hair loss has been shown to be related to scalp skin temperature. Scalp skin temperature, however, is dependent not only on local cooling but also on the thermal status of the body. OBJECTIVES: This study was conducted to investigate the effect of body temper... περισσότερα »

Epstein-Barr virus-positive plasmacytoma in immunocompetent patients.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 1 ώρα

Related Articles *Epstein-Barr virus-positive plasmacytoma in immunocompetent patients.* Histopathology. 2015 Aug;67(2):225-34 Authors: Loghavi S, Khoury JD, Medeiros LJ Abstract AIMS: Extramedullary plasmacytomas are often localized, clinically indolent neoplasms, and affected patients usually respond to radiation therapy or limited cycles of chemotherapy. In contrast, plasmablastic lymphomas are clinically aggressive neoplasms composed of immunoblastic or plasmablastic cells and associated with more mature plasma cells in some cases. Patients with plasmablastic lymphoma usually... περισσότερα »

Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 1 ώρα

Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 1 ώρα

A reference image-based method for optimization of clinical immunohistochemistry.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα

Related Articles *A reference image-based method for optimization of clinical immunohistochemistry.* Histopathology. 2015 Aug;67(2):193-205 Authors: Kap M, Lam KH, Ewing-Graham P, Riegman P Abstract AIMS: Cold ischaemic and formalin fixation time (CIT and FFT) are considered to be crucial parameters for intralaboratory variation in immunohistochemistry (IHC). Here we describe a new method to optimize IHC, by using control tissue blocks with known pre-analytical history and comparing the IHC outcome with digitized reference slides. METHODS AND RESULTS: Tissue specimens (two per ti...περισσότερα »

Prevalence of incidental thyroid nodules in ultrasound studies of dogs with hypercalcemia (2008-2013).

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα

Related Articles *Prevalence of incidental thyroid nodules in ultrasound studies of dogs with hypercalcemia (2008-2013).* Vet Radiol Ultrasound. 2015 Jan-Feb;56(1):63-7 Authors: Pollard RE, Bohannon LK, Feldman EC Abstract Ultrasound is commonly used to evaluate the cervical region in dogs with hypercalcemia due to suspected hyperparathyroidism. Incidental thyroid nodules may be detected during these studies, however little information has been published to guide clinical decision-making when this occurs. The purpose of this cross-sectional study was to determine the prevalence o... περισσότερα »

Thyroid scintigraphy findings in 2096 cats with hyperthyroidism.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα

Related Articles *Thyroid scintigraphy findings in 2096 cats with hyperthyroidism.* Vet Radiol Ultrasound. 2015 Jan-Feb;56(1):84-95 Authors: Peterson ME, Broome MR Abstract Thyroid scintigraphy is currently the reference standard for diagnosing and staging cats with hyperthyroidism, but few studies describing the scintigraphic characteristics in a large number of cats have been reported. The objective of this study was to better characterize thyroid scintigraphy findings by evaluating 2096 consecutive cats with hyperthyroidism that were referred over a 3.5-year period. Of these c... περισσότερα »

A reference image-based method for optimization of clinical immunohistochemistry.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα

Prevalence of incidental thyroid nodules in ultrasound studies of dogs with hypercalcemia (2008-2013).

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα

Thyroid scintigraphy findings in 2096 cats with hyperthyroidism.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα

Comparison of the radiotoxicity of the 99mTc-labeled compounds 99mTc-pertechnetate, 99mTc-HMPAO and 99mTc-MIBI

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

10.3109/09553002.2016.1168533<br>Ute Maucksch from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1YTlDhT via IFTTT

Comparison of the radiotoxicity of the 99mTc-labeled compounds 99mTc-pertechnetate, 99mTc-HMPAO and 99mTc-MIBI

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα

10.3109/09553002.2016.1168533<br>Ute Maucksch from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1YTlDhT via IFTTT

Thyroid carcinoma with rhabdoid phenotype: Case report with review of the literature.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Thyroid carcinoma with rhabdoid phenotype: Case report with review of the literature. Auris Nasus Larynx. 2016 Apr 21; Authors: Lu YT, Huang HI, Yang AH, Tai SK Abstract OBJECTIVE: This paper aims to comprehensively document a rare case of thyroid carcinoma with rhabdoid phenotype and literature review of this disease. METHODS: A 59-year-old man presented… Continue reading Thyroid carcinoma with rhabdoid phenotype: Case report with review of the literature.

Branchial cleft-like cysts in Hashimoto’s thyroiditis: A case report and literature review.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Branchial cleft-like cysts in Hashimoto’s thyroiditis: A case report and literature review. Pathol Int. 2016 May;66(5):297-301 Authors: Miyazaki M, Kiuchi S, Fujioka Y Abstract We report an extremely rare case of branchial cleft-like cysts in Hashimoto’s thyroiditis. The patient was a 77-year-old man with a growing mass in the anterior neck. Ultrasonography and computed tomography… Continue reading Branchial cleft-like cysts in Hashimoto’s thyroiditis: A case report and literature review.

Study on the hemodynamic changes in solid thyroid nodules by ultrasound contrast quantitative analysis.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Related Articles [Study on the hemodynamic changes in solid thyroid nodules by ultrasound contrast quantitative analysis]. Zhonghua Yi Xue Za Zhi. 2015 Nov 17;95(43):3519-22 Authors: Wu C, Zhu L, Chen W, Yan S, Qian L, Zhao C, Xie G, Zheng X Abstract OBJECTIVE: To compare the difference between the different perfusional regions in solid thyroid… Continue reading Study on the hemodynamic changes in solid thyroid nodules by ultrasound contrast quantitative analysis.

microRNA-762 promotes breast cancer cell proliferation and invasion by targeting IRF7 expression.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Related Articles microRNA-762 promotes breast cancer cell proliferation and invasion by targeting IRF7 expression. Cell Prolif. 2015 Dec;48(6):643-9 Authors: Li Y, Huang R, Wang L, Hao J, Zhang Q, Ling R, Yun J Abstract OBJECTIVES: miRNAs play crucial roles in human tumourigenesis. This study was performed to measure expression and function of miR-762 in breast… Continue reading microRNA-762 promotes breast cancer cell proliferation and invasion by targeting IRF7 expression.

SUVmax of 18F-FDG PET/CT in the differential diagnosis of benign and malignant thyroid nodules according to tumor volume.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Related Articles SUVmax of 18F-FDG PET/CT in the differential diagnosis of benign and malignant thyroid nodules according to tumor volume. World J Surg Oncol. 2015;13:217 Authors: Kim TH, Ji YB, Song CM, Kim JY, Choi YY, Park JS, Tae K Abstract BACKGROUND: The aim of this study was to investigate whether the maximum standardized uptake… Continue reading SUVmax of 18F-FDG PET/CT in the differential diagnosis of benign and malignant thyroid nodules according to tumor volume.

Improving the approach to non-diagnostic aspirates: learning from each other.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Related Articles Improving the approach to non-diagnostic aspirates: learning from each other. Endocrine. 2015 Aug;49(3):575-6 Authors: Alexander EK PMID: 25837308 [PubMed – indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1Nzhqzr via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24juKMG via IFTTT

Computerized analysis of calcification of thyroid nodules as visualized by ultrasonography.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Related Articles Computerized analysis of calcification of thyroid nodules as visualized by ultrasonography. Eur J Radiol. 2015 Oct;84(10):1949-53 Authors: Choi WJ, Park JS, Kim KG, Kim SY, Koo HR, Lee YJ Abstract OBJECTIVE: The purpose of this study is to quantify computerized calcification features from ultrasonography (US) images of thyroid nodules in order to determine… Continue reading Computerized analysis of calcification of thyroid nodules as visualized by ultrasonography.

A reference image-based method for optimization of clinical immunohistochemistry.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Related Articles A reference image-based method for optimization of clinical immunohistochemistry. Histopathology. 2015 Aug;67(2):193-205 Authors: Kap M, Lam KH, Ewing-Graham P, Riegman P Abstract AIMS: Cold ischaemic and formalin fixation time (CIT and FFT) are considered to be crucial parameters for intralaboratory variation in immunohistochemistry (IHC). Here we describe a new method to optimize IHC,… Continue reading A reference image-based method for optimization of clinical immunohistochemistry.

Prevalence of incidental thyroid nodules in ultrasound studies of dogs with hypercalcemia (2008-2013).

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Related Articles Prevalence of incidental thyroid nodules in ultrasound studies of dogs with hypercalcemia (2008-2013). Vet Radiol Ultrasound. 2015 Jan-Feb;56(1):63-7 Authors: Pollard RE, Bohannon LK, Feldman EC Abstract Ultrasound is commonly used to evaluate the cervical region in dogs with hypercalcemia due to suspected hyperparathyroidism. Incidental thyroid nodules may be detected during these studies, however… Continue reading Prevalence of incidental thyroid nodules in ultrasound studies of dogs with hypercalcemia (2008-2013).

Thyroid scintigraphy findings in 2096 cats with hyperthyroidism.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Related Articles Thyroid scintigraphy findings in 2096 cats with hyperthyroidism. Vet Radiol Ultrasound. 2015 Jan-Feb;56(1):84-95 Authors: Peterson ME, Broome MR Abstract Thyroid scintigraphy is currently the reference standard for diagnosing and staging cats with hyperthyroidism, but few studies describing the scintigraphic characteristics in a large number of cats have been reported. The objective of this… Continue reading Thyroid scintigraphy findings in 2096 cats with hyperthyroidism.

Gain-Of-Function Mutations In RARB Cause Intellectual Disability With Progressive Motor Impairment

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

ABSTRACT Retinoic acid (RA) signaling plays a key role in the development and function of several systems in mammals. We previously discovered that the de novo mutations c.1159C>T (p.Arg387Cys) and c.1159C>A (p.Arg387Ser) in the RA Receptor Beta (RARB) gene cause microphthalmia and diaphragmatic hernia. However, the natural history of affected subjects beyond the prenatal or […]

Mitochondrial DNA Variation and Heteroplasmy in Monozygotic Twins Clinically Discordant for Multiple Sclerosis

ABSTRACT We examined the debated link between mtDNA variation and multiple sclerosis (MS) using 49 monozygotic (MZ) twin pairs clinically discordant for MS, which enables to associate de novo mtDNA variants, skewed heteroplasmy and mtDNA copy number with MS manifestation. Ultra-deep sequencing of blood-derived mtDNA revealed 25 heteroplasmic variants with potentially pathogenic features in 18 […]

Rare Non-Coding Mutations Extend the Mutational Spectrum in the PGAP3 Subtype of Hyperphosphatasia with Mental Retardation Syndrome

ABSTRACT HPMRS or Mabry syndrome is a heterogeneous glycosylphosphatidylinositol (GPI) anchor deficiency that is caused by an impairment of synthesis or maturation of the GPI-anchor. The expressivity of the clinical features in HPMRS varies from severe syndromic forms with multiple organ malformations to mild non-syndromic intellectual disability. In about half of the patients with the […]

Three Novel Heterozygous Point Mutations of NR3C1 causing Glucocorticoid Resistance

ABSTRACT Generalized glucocorticoid resistance is associated with glucocorticoid receptor (GR, NR3C1) mutations. Three novel heterozygous missense NR3C1 mutations (R477S, Y478C and L672P) were identified in patients presenting with adrenal incidentalomas, glucocorticoid excess without Cushing syndrome. Dexamethasone (DXM) binding studies demonstrated that the affinity of GRR477S and GRY478C mutants, located in the DNA-binding domain of GR, […]

Mutations in GAS8, A Gene Encoding A Nexin-Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia With Axonemal Disorganization

ABSTRACT Primary ciliary dyskinesia (PCD) is an autosomal recessive disease characterized by chronic respiratory infections of the upper and lower airways, hypofertility, and, in approximately half of the cases, situs inversus. This complex phenotype results from defects in motile cilia and sperm flagella. Among the numerous genes involved in PCD, very few —including CCDC39 and […]

Postepy Hig Med Dosw 2016; 70:360-366 «The role of inflammation in colon cancer pathogenesis»

The results of the latest research more and more bind development of neoplasms with the chronic inflammation. Inflammatory process creates microenvironment promoting development of neoplasms; as a result, malignant process start to develop in places, where chronic inflammation proceeds or regeneration of tissues takes place. Inflammatory cells not only create suitable microenvironment for development of […]

Postepy Hig Med Dosw 2016; 70:367-379 «The development of methods for obtaining monoclonal antibody-producing cells»

Monoclonal antibodies (mAbs) are biomolecules of great scientific and practical significance. In contrast to polyclonal antibodies from immune sera, they are homogeneous and monospecific, since they are produced by hybridoma cells representing a clone arising from a single cell. The successful technology was described for the first time in 1975; the inventors were later awarded […]

Postepy Hig Med Dosw 2016; 70:380-391 «Frankincense – therapeutic properties»

Recently, increasing interest in natural dietary and therapeutic preparations used as dietary supplements has been observed. One of them is frankincense. This traditional medicine of the East is believed to have anti-inflammatory, expectorant, antiseptic, and even anxiolytic and anti-neurotic effects. The present study aims to verify the reported therapeutic properties of Boswellia resin and describe […]

Benefits of Zubex beyond glycemic control: Evidence of the antiatherogenic effect

Abstract Objective To determine the effect of Zubex (aqueous extract of Curcuma longa linn, Iron murakab, Eugenia jambolana, Lin seed or flflax seed, processed egg shell calcium and Asphaltum) on plasma sialic acid (PSA) along with cardiovascular (CV) risk factors in streptozotocin-induced diabetic rats. Methods Thirty male albino rats were divided into groups (1–6) with […]

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Τετάρτη 27 Απριλίου 2016