Pancoast tumour presenting as shoulder pain with Horners syndrome

A 54-year-old man presented to the emergency department with a 4-week history of right shoulder pain radiating down his arm, with some associated sensory loss. Further questioning and examination in the department revealed a classical Horner's syndrome; miosis, partial ptosis and hemifacial anhidrosis. An initial chest X-ray was deemed to be unremarkable; however, further review by a radiologist noted asymmetrical right apical thickening. A subsequent high-resolution CT scan of the chest revealed a right-sided Pancoast tumour. This case highlights the importance of a thorough history and examination in identifying a rare cause of shoulder and/or back pain.

http://bit.ly/2B0IaGE

Multiple foreign bodies in the facial region from a penetrating stab injury

Penetrating injuries can lead to multiple retained foreign bodies. To present a case of a penetrating stab injury on to the right orbital region of a 37-year-old woman which resulted in lacerations on both eyelids, loss of vision in addition to the retention of glass particle and woven artificial hair strands at the anterior end of the floor of the orbit. The woven artificial hair strand, being flexible in nature, was apparently logged in by the penetrating force of the broken glass used as the stab injury object. Under local anaesthesia, a gentle intermittent pull on one hair strand led to the dislodgement of a piece of broken glass particle along with the other end of the hair strand. The resultant wound was repaired. Stab injuries can result in retained multiple foreign bodies. This possibility should be considered during assessment and management of facial injuries to avoid complications of retention.

http://bit.ly/2TbUcnx

Editorial Board

http://bit.ly/2B4wSRt

Eine seltene Ursache der chronischen Otitis media

Laryngo-Rhino-Otol
DOI: 10.1055/a-0829-6950

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

http://bit.ly/2TeIJn1

Eine Gruppenintervention zur Förderung der Arbeitsfähigkeit für Patienten mit Kopf-Hals-Tumoren

Laryngo-Rhino-Otol
DOI: 10.1055/a-0829-6885

Einleitung Trotz hoher Belastung nimmt ein Großteil der Patienten mit Kopf-Hals-Tumoren keine psychosoziale Versorgung in Anspruch. Diese Patienten haben darüber hinaus ein höheres Risiko als andere Krebspatienten, nicht wieder in den Beruf zurückzukehren. Daher wurde eine Gruppenintervention entwickelt, die sich an Patienten mit Kopf-Hals-Tumoren richtet und deren Arbeitsfähigkeit, Lebensqualität, Selbstwirksamkeit und psychisches Wohlbefinden fördern soll. Material und Methoden In einem randomisiert-kontrollierten Design erhalten die Patienten eine Gruppenintervention oder eine sozialrechtliche Beratung. Eingeschlossen werden männliche Patienten mit Kopf-Hals-Tumoren mit hoher psychischer und arbeitsbezogener Belastung. Die Gruppenintervention besteht aus acht Sitzungen. Die Gruppen werden von einer Psychotherapeutin und einem ehemals Betroffenen eines Kopf-Hals-Tumors (sogenannter Peer) geleitet. Die Umsetzbarkeit und Akzeptanz der Intervention wurde anhand einer Pilotgruppe getestet. Die Teilnehmer der Pilotgruppe evaluierten jede Sitzung und wurden nach Abschluss der Intervention in halbstrukturierten Interviews zur Intervention befragt. Ergebnisse Von 113 Patienten persönlich angesprochenen Patienten nahmen zehn Patienten an einem Screening-Gespräch teil. Davon nahmen vier Patienten an der Pilotgruppe teil. Die Patienten gaben an, dass sich die Gruppenintervention gut mit ihrem Alltag vereinbaren ließe und dass sie die Gruppe insgesamt positiv wahrgenommen hätten. Drei Patienten betonten die Wichtigkeit des Peers. Diskussion Vor allem der Peers als Identifikationsfigur ist von zentraler Bedeutung. Zur Verbesserung der Rekrutierungszahlen sollen Einschlusskriterien erweitert und der Teilnahmeaufwand reduziert werden.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

http://bit.ly/2B5daFc

REPLY to MS#JAAD-D-19-00075

http://bit.ly/2FM0pUf

Comments on: Abnormal erythrocyte morphology in drug reaction with eosinophilia and systemic symptoms

http://bit.ly/2FUKan3

Impact of the Patient Protection and Affordable Care Act on Dermatologic Healthcare Utilization

http://bit.ly/2FJaKQA

Inpatient consultative dermatology: Where are we now? Assessing the value and evolution of this sub-specialty over the past decade

•The prevalence and complexity of cutaneous disease among hospitalized patients is high. Inpatient consultative dermatology has advanced as a sub-specialty over the past decade to provide much needed expertise regarding uncommon and severe skin disorders. Recent data support the significant value—clinical, outcomes-based, and economic—associated with inpatient dermatology care.

http://bit.ly/2FYaNHy

Examining Cutaneous Disease Activity As An Outcome Measure For Clinical Trials In Dermatomyositis

http://bit.ly/2FPNfFE

The Impact of Testosterone on the Chests and Abdomens of Transgender Men

http://bit.ly/2FVrymG

Chronic Itch Management: Therapies Beyond Those Targeting the Immune System

Itch, a sensation that leads to a desire to scratch, becomes chronic when it persists for more than 6 weeks.1 Chronic itch can be debilitating and lead to a significantly reduced quality of life. It affects sleep, mood, and can cause symptoms of anxiety and depression.2 Pruritus may be perpetuated by inflammatory conditions, as seen in atopic dermatitis and psoriasis. However, chronic pruritus may not always have an inflammatory component, and therefore requires treatments that do not work on the immune system, but instead target the nerves.

http://bit.ly/2G3djfZ

From the pages of AllergyWatch

J Allergy Clin Immunol Pract. 2018;6:1274-1286

http://bit.ly/2FJzubH

Pattern of Medication Use in Children with Very Poorly Controlled Asthma

Tables: 1

http://bit.ly/2FWOSR7

Clinical features and mechanistic insights regarding IgG4-related dacryoadenitis and sialoadenitis: a review

Immunoglobulin G4-related disease (IgG4-RD), recognized only recently as a single diagnostic entity, is a chronic inflammatory condition of unknown etiology. The diagnosis of IgG4-RD relies heavily on histopathological analysis and the correlation of histology findings with clinical, serological, and radiological data. CD4+ T and B cells, including IgG4-expressing plasmablasts, constitute the major inflammatory cell populations in IgG4-RD and are believed to cause organ damage and tissue fibrosis.

http://bit.ly/2B3vTkN

Role of a two-step suture in the prevention of postoperative transoral salivary fistulas during reconstruction of the oral cavity

Transoral salivary fistulas are one of the most serious postoperative complications after operations for oral cancer, and we propose a new, two-step suture method to avoid them. From January 2005 to September 2017, 240 patients were recruited at the Shanghai Ninth People's Hospital and divided into experimental (n=89) or control (n=151) groups. The experimental group was treated by a two-step suture technique, while the control group had conventional sutures. Statistical differences were assessed using the chi squared and t tests, as appropriate.

http://bit.ly/2sOoPDL

No Evidence of Broadband Noise Having Any Harmful Effect on Hearing

To the Editor Attarha et al recommended that sound therapies using white noise should be avoided as treatments for tinnitus. This advice might stem from the authors' collective lack of clinical experience assessing and treating patients with tinnitus, or from their unfamiliarity with tinnitus management techniques and associated literature. In any case, before recommending that white noise should be avoided by patients with tinnitus, Attarha et al should become more familiar with how a variety of sound therapies—including broadband sounds—often help this patient population.

http://bit.ly/2FMXWsK

Bullous Pemphigoid Presenting as Oropharyngeal Hemorrhage

This is a case report of a man who presented with oropharyngeal hemorrhage and impending airway compromise as the initial presentation of mucosal bullous pemphigoid.

http://bit.ly/2FVKNwA

Association Between Migraine and Benign Paroxysmal Positional Vertigo in South Korea

This study evaluates representative patient data from the Korean National Health Insurance Service-National Sample Cohort to trace the incidence of benign paroxysmal positional vertigo among adults who experience migraine.

http://bit.ly/2FMXWce

No Evidence of Broadband Noise Having Any Harmful Effect on Hearing—Reply

In Reply Critiques of our article by Folmer and Henry et al suggest the concerns we raised about the potential harmful effects of chronic exposure to broad-band noise (BBN) are overstated, citing a lack of clinical evidence demonstrating correspondence between human symptoms and maladaptive neuroplasticity recorded in animal studies. Although we acknowledged the paucity of human studies addressing these questions in our review, we do not think it is safe to assume humans will be exempt from substantial, negative impacts of chronic BBN exposure documented in the central auditory pathways of animals. A main goal of our report was to stimulate the audiology research and clinical communities to take these compelling animal studies more seriously—and to take on the long-delayed task of carefully documenting the impacts of chronic BBN exposure on residual human hearing, on accelerated aging, and on the evolution of tinnitus itself.

http://bit.ly/2FXHZ1S

Speech Functioning and Neurocognition Before Head and Neck Cancer

This cohort study examines neurocognitive functioning in patients with head and neck cancer before treatment and investigates the association between neurocognition and speech functioning.

http://bit.ly/2FLAqvZ

The Increasing Role of Social Media in Otolaryngology

This Viewpoint examines the increasing role of social media in the practice of otolaryngology.

http://bit.ly/2FVKAcM

No Evidence of Broadband Noise Having Any Harmful Effect on Hearing

To the Editor We are writing in response to the article by Attarha, Bigelow, and Merzenich, which concluded, "Sound therapies using unstructured, random (white) noise should be avoided as a treatment for tinnitus."^(E1) Their recommendation was based on animal studies that revealed long-term exposure to low-level broadband noise (BBN) resulted in central auditory changes that "bear striking phenomenological overlap with the persistent, widespread disinhibition of the auditory system thought to underlie tinnitus in humans."^(E2) They noted that BBN delivered from ear-level devices to treat tinnitus produces the same type of acoustic stimuli used in the animal studies. It therefore seems plausible that continuous use of BBN could affect the human auditory system in the same manner as seen in animals, suggesting the need for research to evaluate the premise. The authors, however, pointed to the animal findings as justifying a broad recommendation against the use of ear-level noise generators.

http://bit.ly/2FJicLP

Morbidity and mortality among patients with head and neck cancer in the emergency department: A national perspective

Abstract

Background

Emergency departments are playing an increasing role in cancer management. Emergency department utilization by patients with head and neck cancer, however, is unknown.

Methods

The 2009‐2011 Nationwide Emergency Department Sample was queried for patients with a principle diagnosis of head and neck cancer. Descriptive analysis was performed to characterize patient and hospital characteristics, outcomes, and charges. Logistic regression identified predictors of admission and mortality.

Results

A total of 31 390 patients were seen in the emergency department with head and neck cancer: 72.8% were admitted, 0.5% died in the emergency department, and 5.0% died during admission. Patients with cancer of unknown primary site had the greatest odds of admission (odds ration [OR]: 2.83; P < 0.0001). Privately insured patients (OR: 1.78; P = 0.001), those from higher income zip codes (OR: 1.56; P = 0.008), and those with oropharyngeal cancer (OR: 2.02; P = 0.0003) had the greatest odds of death.

Conclusion

These findings have direct implications for preventing unnecessary and costly emergency department visits, improving hospital and physician preparedness, and improving patient outcomes.

http://bit.ly/2S9wBq8

Follow‐up of noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP)

http://bit.ly/2Hu7QAR

Ultrasonographic swallowing examination for early detection of neopharyngeal fistula after salvage total laryngectomy: A preliminary study

Abstract

Background

The current study investigated the feasibility of ultrasonographic swallowing examination (USSE) for the evaluation of neopharynx and early detection of neopharyngeal fistula after salvage total laryngectomy.

Methods

A prospective case series‐based study involving 16 patients who underwent salvage total laryngectomy was conducted. USSE was performed on postoperative days 5‐7, and oral diet initiation was determined based on the USSE results.

Results

Fistula of the neopharynx was detected in four patients (25%) via USSE, as was the specific site of the fistula. In these patients, oral diet was delayed and immediate interventions including ultrasound‐guided fluid aspiration and compression dressing were applied, and all fistulas were subsequently closed. In the remaining 12 patients with no neopharyngeal fistula on USSE, an oral diet was started immediately and no fistula occurred.

Conclusions

USSE is a promising method for neopharynx evaluation and early detection of neopharyngeal fistula after salvage total laryngectomy.

http://bit.ly/2S5fB4q

Intracameral Air and Fibrin Glue for the Management of Late Bleb Leak following Glaucoma Surgery

Background and Objectives: To report a case of delayed-onset bleb-associated endophthalmitis (BAE) with bleb leak successfully managed with pars plana vitrectomy, intravitreal antibiotics, intracameral air, and fibrin glue. Patient and Methods: A 66-year-old pseudophakic female presented with BAE and bleb leak. A 25-gauge pars plana vitrectomy, cultures, and intravitreal antibiotics and steroid injections were performed. The infusion was switched to air filling the anterior chamber and bleb with air. Fibrin glue (Tisseel®) was applied over the leaking bleb. Results: BAE and bleb leak resolved with return of visual acuity to 20/25 and a functioning bleb with no recurrence of bleb leak after 1 year of follow-up. Conclusion: The combination of intracameral air and fibrin glue may have a role in the management of bleb leaks.
Case Rep Ophthalmol 2019;10:47–52

http://bit.ly/2Ta5pVv

Penetrating Eyelid and Ocular Fishhook-Related Injury

Purpose: To report removal techniques and outcomes for a patient with penetrating eyelid and cornea complicating localized retinal detachment from a fishhook. Methods: This is a case report of a 35-year-old man who presented with a fishhook embedded in his right upper eyelid and globe while participating in a fishing competition. On initial examination, his right eyelid was opened with difficulty and limited evaluation could be performed. Results: In an operating room, a shank was transected and removed from a lacerated eyelid by a back-out technique. Then, a barbed hook was noticed to penetrate through temporal peripheral cornea, iris, and entrapped within ciliary body behind the lens. A successful surgical removal of a fishhook was performed within a primary operation. After that, additional operations to repair injured ocular tissues including a localized retinal detachment were performed. The patient achieved a best-corrected visual acuity of 20/20 at 10-month follow-up. Conclusions: The visual prognosis for a fishhook-related ocular injury is associated with various variables including size and location of lacerated wound and technique to remove a fishhook. In this case, a patient could achieve a favorable final visual and anatomical outcome. This removal technique could be taken into consideration when encountering a fishhook-related eye injury patient.
Case Rep Ophthalmol 2019;10:41–46

http://bit.ly/2B0aY1G

Neurosarcoidosis Occurring 6 Years after Onset of Vogt-Koyanagi-Harada Disease

A 43-year-old Japanese woman visited a clinic with a 2-week history of visual loss, hyperemia, and bilateral eye pain. Dilated fundus and optical coherence tomography showed hyperemic optic disc and multifocal serous retinal detachments. Fundus fluorescein angiography revealed optic disc leakage and numerous hyperfluorescent pinpoints of leakage, which are typical of Vogt-Koyanagi-Harada disease (VKHD). She also showed tinnitus, poliosis, and alopecia. With a diagnosis of VKHD, steroid therapy was started. At the age of 48, oral prednisolone was tapered off, and only corticosteroid eye drops were continued. Eighteen months later, dysesthesia appeared in the left side of her face and in her left ring and little fingers, which spread to the ulnar side of her forearm. Blood tests indicated elevated serum angiotensin-converting enzyme (ACE) levels. Chest CT showed bilateral lymphadenopathy, and histological analysis of the subcutaneous mass in her right arm showed multinucleated giant cells. Steroid therapy was started under a diagnosis of sarcoidosis. Serum ACE and lysozyme levels decreased in response to steroid therapy. We report a case of the concurrence of VKHD and sarcoidosis, which may share a common pathophysiology. Accumulation of further similar cases is necessary to elucidate the precise mechanism underlying the concurrence of these two diseases.
Case Rep Ophthalmol 2019;10:32–40

http://bit.ly/2T7ekal

Two-Year Outcome of Aflibercept for the Treatment of Choroidal Neovascularization in Punctate Inner Choroidopathy

Punctate inner choroidopathy (PIC) is a rare inflammatory chorioretinopathy that predominantly affects young myopic women. Visual prognosis is generally good, but occurrence of choroidal neovascularization (CNV) is common and may be vision threatening. Case reports and short case series support the effectiveness of intravitreal anti-vascular endothelial growth factor (VEGF) agents (ranibizumab and bevacizumab) for CNV associated with PIC given their anti-angiogenic and anti-inflammatory effects. Evidence concerning aflibercept, a more recent intravitreal anti-VEGF, is limited to a single case report. In this case report, we illustrate the case of a 43-year-old myopic woman presenting with visual acuity loss and distortion in the right eye over the last 5 days in whom CNV associated with PIC was diagnosed. Treatment with 1 injection per month of intravitreal aflibercept for 2 months and full-dose oral prednisone for 1 week, being tapered afterwards, improved visual acuity and resolved CNV, with benefits lasting up to 24 months.
Case Rep Ophthalmol 2019;10:24–31

http://bit.ly/2B0Z6g2

Deep sequencing reveals specific bacterial signatures in the subgingival microbiota of healthy subjects

Abstract

Objectives

This study aimed to define the comprehensive bacterial flora of the healthy oral cavity by identifying and comparing bacterial species in different subgingival sites using 454 sequencing of 16S rRNA genes.

Materials and methods

Subgingival plaque samples were taken from six target teeth (central incisor, first premolar, and first molar in both the maxilla and mandible) of 10 periodontally healthy patients. Bacterial DNA was extracted and next-generation sequencing of 16S rRNA genes was performed.

Results

Bacterial composition in phylum level was similar for all sites within the same individual irrespective of tooth location. Unweighted UniFrac distance values of microbiome also showed that average distance was significantly larger between subjects than between tooth locations of the same subjects.

Conclusions

The present results clarify the lack of effect of tooth location in the healthy subgingival microbiota. Results may suggest that any subgingival site can demonstrate similar subject-specific microbiota.

Clinical relevance

This investigation offers a better understanding of the uniqueness of the oral microbiome. The present study will facilitate sampling in future subgingival microbiological studies.

http://bit.ly/2DxfvdK

Feasibility of carbon‐ion radiotherapy for oral non‐squamous cell carcinomas

Abstract

Background

This study evaluated carbon‐ion radiotherapy (C‐ion RT) for oral non‐squamous cell carcinomas (non‐SCC).

Methods

We retrospectively obtained data from 74 patients who underwent C‐ion RT for oral malignancies between April 1997 and March 2016. The C‐ion RT was administered in 16 fractions at a total dose of 57.6 or 64.0 Gy (relative biological effectiveness).

Results

Forty‐three patients had salivary gland carcinomas, 29 patients had mucosal melanoma, and 2 patients had other types of pathologies. The tumors were classified as T1‐T3 (24 cases), T4a (21 cases), or T4b (29 cases). The median follow‐up was 49 months. The 5‐year rates were 78.8% for local control, 36.2% for progression‐free survival, and 58.3% for overall survival. Although 10 patients developed grade 3 osteoradionecrosis after C‐ion RT, all patients maintained their mastication and deglutition functions after sequestrectomy and prosthesis placement.

Conclusion

C‐ion RT was effective for oral non‐SCC and had acceptable toxicities.

http://bit.ly/2sFzQrc

Anatomy Pathology

 Annals of Diagnostic Pathology

The frequency of <em>NOTCH1</em> variants in T-acute lymphoblastic leukemia/lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma among Jordanian patients

Publication date: Available online 24 January 2019Source: Annals of Diagnostic PathologyAuthor(s): Nezeen Z. Abualhaj, Zain Dardas, Belal Azab, Dema Ali, Maher A. Sughayer, Tariq N. Aladily, Mamoun AhramAbstractThe transmembrane receptor NOTCH1 is thought to be associated with the development and progression of T-acute lymphoblastic leukemia (T-ALL)/T-lymphoblastic lymphoma (T-LBL) and chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). The current study aimed to characterize NOTCH1...

Annals of Diagnostic Pathology

4h

Mark above section as read

 Pathology International

Combined hepatocellular‐cholangiocarcinoma with angiosarcomatoid change: A case report with immunohistochemical study

Sarcomatoid combined hepatocellular‐cholangiocarcinoma (cHCC‐CCA) is a rare condition, with only 16 cases reported to date; however, there have been no reports of hepatic sarcomatoid carcinoma with angiosarcomatous features. Here, we report a rare case of cHCC‐CCA with angiosarcomatoid changes in a 77‐year‐old man. The tumor was biphasic with malignant epithelial and mesenchymal components. Histologically, the epithelial component was concordant with classical type cHCC‐CCA. The mesenchymal component...

Pathology International

1d

Intravascular large B‐cell lymphoma involving large blood vessels, three autopsy cases

Although intravascular large B‐cell lymphoma (IVLBCL) is an extranodal lymphoma characterized by the selective growth of lymphoma cells within the lumina of small vessels, we here report three autopsy cases of IVLBCL characterized by the proliferation within large blood vessels. These three cases were diagnosed as IVLBCL of the bone marrow or skin biopsy. Two cases died suddenly before treatment, whereas the other died during treatment. Autopsies showed a large embolus of dense lymphoma cells extending...

Pathology International

1d

Mark above section as read

 Cells Tissues Organs

Whey Protein Complexes with Green Tea Polyphenols: Antimicrobial, Osteoblast-Stimulatory, and Antioxidant Activities

Polyphenols are known for their antimicrobial activity, whilst both polyphenols and the globular protein β-lactoglobulin (bLG) are suggested to have antioxidant properties and promote cell proliferation. These are potentially useful properties for a tissue-engineered construct, though it is unknown if they are retained when both compounds are used in combination. In this study, a range of different microbes and an osteoblast-like cell line (human fetal osteoblast, hFOB) were used to assess the combined...

Cells Tissues Organs

2h

Two Web Resources Linking Major Human Embryology Collections Worldwide

Human embryology is a core subject for medicine and current research. While animal models of development now have significant online resources available, the vast majority of human embryonic material is locked up in historic collections. When accessed today, these collections are still contributing to our understanding of human development. This paper describes two online resources for studying human development that are unlocking these invaluable collections and providing related human developmental...

Cells Tissues Organs

1d

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 Case Reports in Pathology

A Rare Case of Fibrous Hamartoma of Infancy: A Clinicopathological Diagnosis at a Tertiary Hospital, Eastern Nepal

Background. Fibrous hamartoma of infancy is a rare soft tissue lesion of infants and young children with characteristic triphasic morphology. Case Description. An 18-month-old female child was presented with complaints of swelling over right leg shin since birth. On examination, a lump of size 7x3 cm was identified which was mobile and nontender. Local excision was performed and tissue sent for histopathological examination. On gross examination, a globular, capsulated, firm to hard tissue had cut...

Case Reports in Pathology

1d

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 Cancer Cytopathology

The prevalence and surgical outcomes of Hurthle cell lesions in FNAs of the thyroid: A multi‐institutional study in 6 Asian countries

Background Hurthle cell‐rich nodules (HCNs) encompass non‐neoplastic to malignant lesions. There is paucity of literature on the frequency distribution of HCNs among Bethesda categories, histologic follow‐up, risk of malignancy (ROM), and risk of neoplasia (RON). The objective of this retrospective, multi‐institutional study was to determine the prevalence of the cytologic diagnostic category and surgical outcomes of patients with HCN. Methods Nine tertiary health centers representing 6 Asian...

Cancer Cytopathology

1d

Negative predictive value and sensitivity of urine cytology prior to implementation of The Paris System for Reporting Urinary Cytology

Background Urinary tract cytology (UTCy) is used for screening urothelial carcinoma (UC) and it must have a high negative predictive value (NPV) to be an effective test. To the authors' knowledge, the literature regarding the NPV of UTCy provides little information regarding the risk of malignancy, especially for patients with high‐grade urothelial carcinoma (HGUC). Methods Patients with negative UTCy specimens were identified in the pathology files at the study institution for the years 2012...

Cancer Cytopathology

1d

The value of cytology in the management of patients with pancreatic cysts

Cancer Cytopathology

1d

OroFacial Medicine

Prevalence of oral mucosal disorders during pregnancy: A systematic review and meta‐analysis

Abstract Objective To assess the prevalence of oral mucosal disorders during pregnancy. Methods Observational studies were selected by two reviewers in a two‐phase process. Search strategies were applied at CINAHL, LILACS, LIVIVO, PubMed, Scopus, Web of Science, Google Scholar, Open Grey, and ProQuest. The risk of bias was assessed using the Joanna Briggs Institute's Critical Appraisal Checklist for Studies Reporting Prevalence Data. Synthesis of results was calculated by the software R...

Oral Pathology & Medicine

4h

Skeletal stability in orthognathic surgery with the surgery first approach: a systematic review

Publication date: Available online 23 January 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): D. Soverina, G. Gasparini, S. Pelo, P. Doneddu, M. Todaro, R. Boniello, C. Azzuni, C. Grippaudo, G. Saponaro, G. D'Amato, U. Garagiola, A. MoroAbstractThe surgery first approach (SFA) is a therapeutic strategy used in orthognathic surgery that is constantly evolving. With this approach, the pre-surgical orthodontic treatment can be eliminated, the maxilla and the mandible are...

Oral and Maxillofacial Surgery

5h

Pharyngeal airway space changes after maxillomandibular advancement: a five-year retrospective study

Publication date: Available online 23 January 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): P.M. Araújo, R.L.V. Osterne, A.C.G. de Souza Carvalho, N.O. Azevedo, R.F. Gondim, R.T. Gonçalves Filho, E. Sant'Ana, R.L.M. NogueiraAbstractThe aim of this study was to compare the alterations in three regions of the airway—nasopharynx, oropharynx, and hypopharynx—in relation to the area of the midsagittal plane, volume, and minimal axial area after maxillomandibular advancement...

Oral and Maxillofacial Surgery

5h

Assessment of metal sleeve-free 3D-printed implant surgical guides

Publication date: Available online 23 January 2019Source: Dental MaterialsAuthor(s): Kyung Chul Oh, Ji-Man Park, June-Sung Shim, Jee-Hwan Kim, Jong-Eun Kim, Jang-Hyun KimAbstractObjectivesThe aim of the present study was to investigate the adaptation and guide hole tolerance of metal sleeve-free computer-assisted implant surgical guides fabricated with 3D printers.MethodsAn implant surgical guide for full-guided implant placement was designed with a total of eight different guide holes. Ten implant...

Dental Materials

5h

Microvascular reconstruction and dental rehabilitation of benign severely atrophic jaws and defects of the alveolar ridge: our philosophy in 2019

We deal regularly with patients who present with severe atrophy of the jaws, compromised soft tissue, or penetrating defects of the alveolar ridge that are not the result of malignant disease. For these patients we use microvascular bony flaps together with dental implants and implant-supported prostheses. The purpose of this retrospective study was to present our current management and the lessons we have learned over a 16-year period while treating 86 patients for these indications with 87 microvascular...

Oral and Maxillofacial Surgery

15h

Pharyngeal airway space changes after maxillomandibular advancement: a five-year retrospective study

The aim of this study was to compare the alterations in three regions of the airway—nasopharynx, oropharynx, and hypopharynx—in relation to the area of the midsagittal plane, volume, and minimal axial area after maxillomandibular advancement (MMA) surgery. Thirty patients who had undergone MMA surgery were evaluated at four time points: preoperative (T0), immediately postoperative (T1), 1year postoperative (T2), and ≥5 years postoperative (T3). All measurements were performed using computed tomography,...

Oral & Maxillofacial Surgery

16h

Skeletal stability in orthognathic surgery with the surgery first approach: a systematic review

The surgery first approach (SFA) is a therapeutic strategy used in orthognathic surgery that is constantly evolving. With this approach, the pre-surgical orthodontic treatment can be eliminated, the maxilla and the mandible are surgically repositioned into the desired position, and the therapy is ended with a short orthodontic phase. Several studies have reported that the SFA is an acceptable approach, but postoperative stability is unclear. In this study, a systematic review on the SFA was performed.

Oral & Maxillofacial Surgery

16h

Predictive value of FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas: a retrospective study

Abstract Objectives The aim of this study was to investigate the predictive value of the biomarkers FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas. Material and methods Immunohistochemical staining of FHIT, p27, and pERK1/ERK2 of 265 patients with salivary gland carcinomas was conducted, and associations with clinico-histopathological data, overall...

Clinical Oral Investigations

18h

Fludroxycortide cream as an alternative therapy for actinic cheilitis

Abstract Objectives The objective of the study is to assess, by clinical follow-up, the efficacy of the dermatological cream Fludroxycortide 0.125 mg/g (Drenison®) in the treatment of actinic cheilitis (AC). Material and methods Twenty-three patients diagnosed with AC participated in the study. Fifteen were submitted to corticotherapy with Fludroxycortide,...

Clinical Oral Investigations

18h

Systemic comorbidities are associated with medication‐related osteonecrosis of the jaws: case‐control study

Abstract Objectives Medication‐related osteonecrosis of the jaws (MRONJ) is a serious condition developed in up to 15% of patients who take antiresorptive medications. Its underlying pathogenesis remains unclear. The association between systemic comorbidities and MRONJ was investigated. Subjects and Methods A case‐control study was conducted in Brisbane, Australia. Hospital records were used to identify 68 cases of MRONJ between January 2003‐ March 2017. Each case was individually matched...

Oral Diseases

20h

The role of autophagy in the pathogenesis of periodontal disease

Abstract Periodontal disease is a chronic inflammatory disease leading to destruction of periodontal tissues. As a local inflammation, periodontopathic bacterium, pro‐inflammatory mediators and local immune response play pivotal role in the progress of periodontal disease. Besides, cigarette smoke has long been associated with periodontal disease and tooth loss. Autophagy is an intracellular degradation process highly conserved from yeast to humans. As a lysosomal degradation pathway of self‐digestion,...

Oral Diseases

20h

Following in the footsteps of Hippocrates—interrelation between the incidence of odontogenic abscess and meteorological parameters

Abstract Objectives Although many physicians in daily practice assume a connection between odontogenic infections and meteorological parameters, this has not yet been scientifically proven. Therefore, the aim of the present study was to evaluate the incidence of odontogenic abscess (OA) in relation to outdoor temperature and atmospheric pressure. Patients and methods ...

Clinical Oral Investigations

20h

Scanning electron microscopy analysis of aligner fitting on anchorage attachments

Abstract Purpose The aims of the study were (1) to evaluate the fitting of three different aligners (Invisalign [Align Technology, Santa Clara, CA, USA], CA Clear Aligner [Scheu-Dental, Iserlohn, Germany] and F22 [Sweden&Martina, Due Carrare, Italy]) on anchorage attachments using scanning electron microscopy (SEM), and (2) to analyze the influence of 2 different types of resin used to build attachments on aligner fitting. ...

Latest Results for Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie

22h

Impact of breastfeeding and/or bottle-feeding on surgical wound dehiscence after cleft lip repair in infants: a systematic review

Publication date: Available online 23 January 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Eriko Matsunaka, Shingo Ueki, Kiyoko MakimotoSummaryBackgroundImmediately after cleft lip repair, breastfeeding and bottle-feeding are generally restricted to avoid placing tension on the surgical incision. However, no consensus about feeding methods after cleft lip repair has been reached. The objective of this systematic review was to examine the impact of breastfeeding and/or bottle-feeding...

Cranio-Maxillofacial Surgery

1d

An <em>in vitro</em> long-term study of cryopreserved umbilical cord blood-derived platelet-rich plasma containing growth factors—PDGF-BB, TGF-β, and VEGF

Publication date: Available online 22 January 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Kyoko Baba, Yasuharu Yamazaki, Yumiko Sone, Yoshika Sugimoto, Kazuno Moriyama, Takayuki Sugimoto, Kennichi Kumazawa, Yasuhito Shimakura, Akira TakedaSummaryPurposeUmbilical cord blood-derived platelet-rich plasma (UCB-PRP) containing growth factors has attracted attention as a biomaterial useful for regenerative medicine. The osteoblastic differentiation of umbilical cord-derived mesenchymal...

Cranio-Maxillofacial Surgery

1d

Analysis of the association of <em>IL4</em> polymorphisms with orthodontic mini-implant loss

Publication date: Available online 23 January 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): T.F. Lopes, C.M. Souza, A.M. Reichow, A.C. Melo, P.C. TrevilattoAbstractThe aim of this study was to investigate the association of clinical characteristics and IL4 tag single nucleotide polymorphisms (SNPs; rs2227284 and rs2243268) with orthodontic mini-implant (MI) failure. The sample included 135 subjects of both sexes, mean age 48.7 ± 10 years (range 20–76 years): 104 in...

Oral and Maxillofacial Surgery

1d

Implant fracture failure rate and potential associated risk indicators: An up‐to 12‐year retrospective study of implants in 5124 patients

Abstract Objectives This study investigated fracture rates and risk indicators for fractures in internal connection dental implants. Material and Methods We performed a retrospective analysis of 19,006 internal connection implants used in fixed restoration in 5,124 patients (4,570 males, 554 females) at the Dental Hospital of Veterans Health Service Medical Center between 2006 and 2015. Patients were followed through June 2018 (0.03–12.39 years post‐installation). Clinical factors (age,...

Clinical Oral Implants Research

1d

Assessment of Interleukin – 18 gene polymorphism and serum levels in Oral Lichen Planus in an Indian population

Abstract Background Oral Lichen Planus (OLP) is a chronic, inflammatory disease with uncertain aetiology. The aim of this study was to assess Interleukin‐18 (IL‐18) gene polymorphism and serum levels in OLP cases of Indian origin and to compare them with a control population of similar background. Methods Assessment of single nucleotide polymorphisms (SNPs) of IL‐18 gene at promoter regions 137(G/C) and 607(C/A) was done in 70 OLP cases and 70 healthy controls using sequence specific primer‐polymerase...

Oral Pathology & Medicine

1d

N-acetyl cysteine versus chlorhexidine mouthwashes in prevention and treatment of experimental gingivitis: a randomized, triple-blind, placebo-controlled clinical trial

Abstract Objectives To compare the efficacy of N-acetyl cysteine (NAC) mouthwash with chlorhexidine (CHX) in prevention and treatment of experimental gingivitis Materials and methods Sixty subjects were assigned randomly and blindly into one of three equal groups: NAC, CHX, or placebo group. The study was conducted in two stages: preventive and treatment...

Clinical Oral Investigations

1d

Investigation into the accuracy and measurement methods of sequential 3D dental scan alignment

Publication date: Available online 23 January 2019Source: Dental MaterialsAuthor(s): Saoirse O'Toole, Cecilie Osnes, David Bartlett, Andrew KeelingAbstractObjectivesAlignment procedures have yet to be standardised and may influence the measurement outcome. This investigation assessed the accuracy of commonly used alignment techniques and their impact on measurement metrics.MethodsDatasets of 10 natural molar teeth were created with a structured-light model-scanner (Rexcan DS2, Europac 3D, Crewe)....

Dental Materials

1d

A novel histopathological scoring system for patients with oral squamous cell carcinoma

Abstract Objectives Tumor invasion into blood and/or lymphatic vessels, perineural invasion, and histopathological grading are evaluated to assess the biological aggressiveness of oral squamous cell carcinoma (OSCC). We aim to assess the prognostic impact of a novel scoring system, based upon the aforementioned histological parameters. Materials and methods ...

Clinical Oral Investigations

1d

Analysis of the association of IL4 polymorphisms with orthodontic mini-implant loss

The aim of this study was to investigate the association of clinical characteristics and IL4 tag single nucleotide polymorphisms (SNPs; rs2227284 and rs2243268) with orthodontic mini-implant (MI) failure. The sample included 135 subjects of both sexes, mean age 48.7±10years (range 20–76years): 104 in the control group (patients without any MI loss) and 31 in the study group (patients presenting ≥1 MI loss). Genotypes were determined by real-time PCR. Bivariate and multivariate analyses were performed...

Oral & Maxillofacial Surgery

1d

Influence of Porphyromonas gingivalis in gut microbiota of streptozotocin‐induced diabetic mice

Abstract Objectives Increasing evidence suggests that periodontitis can exacerbate diabetes, and gut bacterial dysbiosis appears to be linked with the diabetic condition. The present study examined the effects of oral administration of the periodontopathic bacterium, Porphyromonas gingivalis, on the gut microbiota and systemic conditions in streptozotocin‐induced diabetic mice. Materials and Methods Diabetes was induced by streptozotocin injection in C57BL/6J male mice (STZ). STZ and wild‐type...

Oral Diseases

1d

Overexpression of EphrinB2 in Stem Cells from Apical Papilla Accelerates Angiogenesis

Abstracts Objectives we aimed to accelerate angiogenesis in pulp regeneration by modulating ephrinB2 expression in stem cells from apical papilla (SCAPs). Materials and Methods SCAPs were transducted with ephrinB2‐lentiviral expression vector in experimental group (ephrinB2‐SCAPs) and green fluorescent protein (GFP‐SCAPs) in control group. The transduction efficiency was confirmed by real‐time PCR and western blot assays. MTT assay was performed to detect the proliferative capacity of SCAPs...

Oral Diseases

1d

Inhibition of secondary caries <em>in vitro</em> by addition of chlorhexidine to adhesive components

Publication date: Available online 22 January 2019Source: Dental MaterialsAuthor(s): Christina Boutsiouki, Roland Frankenberger, Susanne Lücker, Norbert KrämerAbstractObjectiveTo investigate secondary caries inhibition after dentine pre-treatment with 2% CHX, experimental addition of CHX in primer and adhesive of a 3-step adhesive system, and industrial addition od CHX in a 2-step adhesive system.Materials and methodSixty Class-V cavities were restored according to the adhesive protocol (n = 12):...

Dental Materials

2d

Hydrophobicity of graphene as a driving force for inhibiting biofilm formation of pathogenic bacteria and fungi

Publication date: Available online 21 January 2019Source: Dental MaterialsAuthor(s): Shruti Vidhawan Agarwalla, Kassapa Ellepola, Mariana Caldeira Ferraz da Costa, Guilhermino José Macêdo Fechine, Julien Luc Paul Morin, A.H. Castro Neto, Chaminda Jayampath Seneviratne, Vinicius RosaAbstractObjectiveTo evaluate the surface and wettability characteristics and the microbial biofilm interaction of graphene coating on titanium.MethodsGraphene was deposited on titanium (Control) via a liquid-free technique....

Dental Materials

2d

Combining Platelet Rich Fibrin With Different Bone Graft Materials: An Experimental Study On The Histopathological And Immunohistochemical Aspects Of Bone Healing

Publication date: Available online 22 January 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Fatih Karayürek, Ela Tules Kadiroğlu, Yusuf Nergis, Neslihan Coşkun Akçay, Selçuk Tunik, Berna Ersöz Kanay, Ersin UysalAbstractAimThe current study was based on the hypothesis that the use of PRF with bone graft materials might increase bone regeneration and focus on the histopathological and immunohistochemical aspects following application of PRF with autogenous graft, xenograft and B-TCP...

Cranio-Maxillofacial Surgery

2d

The preventive effect of decellularized pericardial patch against Frey's syndrome following the superficial parotidectomy

Publication date: Available online 22 January 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Chengyong Wang, Dong Wu, Chuanqing Mao, Meng Lu, Zhiyu Cai, Yongzhen Lai, Weihui ChenSummaryPurposeThis study aimed to investigate the feasibility of adopting the ThormalGEN surgical patch (a porcine decellularized pericardial patch) in the superficial parotidectomy to prevent postoperative Frey's syndrome in patients with benign parotid tumor.Materials and MethodsA total of 59 patients with...

Cranio-Maxillofacial Surgery

2d

Examination of <em>OPG</em>, <em>RANK</em>, <em>RANKL</em> and <em>HIF1A</em> polymorphisms in temporomandibular joint ankylosis patients

Publication date: Available online 21 January 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Paola Fernanda Cotait de Lucas Corso, Michelle Nascimento Meger, Igor Bassi Ferreira Petean, Juliana Feltrin de Souza, João Armando Brancher, Lea Assed Bezerra da Silva, Nelson Luis Barbosa Rebelatto, Leandro Eduardo Kluppel, Manoel Damião Sousa-Neto, Erika Calvano Küchler, Rafaela ScariotSummaryPurposeTo evaluate the association between polymorphisms in genes that regulate bone metabolism,...

Cranio-Maxillofacial Surgery

2d

Comparative evaluation of different fixation techniques for sagittal split ramus osteotomy in 10 mm advancements. Part two: finite element analysis

Publication date: Available online 21 January 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Eder Alberto Sigua-Rodriguez, Ricardo Armini Caldas, Douglas Rangel Goulart, Paulo Hemerson de Moraes, Sergio Olate, Valentim Adelino Ricardo Barão, Jose Ricardo de Albergaria-BarbosaAbstractPurposeTo evaluate three rigid, stable fixation methods for sagittal split ramus osteotomy (SSRO), using finite element analysis. The hypothesis is that a customized miniplate presents better stress concentration...

Cranio-Maxillofacial Surgery

2d

Comprehensive assessment of tranexamic acid during orthognathic surgery: a systematic review and meta-analysis of randomized, controlled trials

Publication date: Available online 21 January 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Haoming Zhao, Shaopeng Liu, Zuping Wu, Huaqiang Zhao, Chuan MaAbstractThe objective of this study was to comprehensively assess the use of tranexamic acid (TXA) during orthognathic surgery. A systematic review and meta-analysis of randomized controlled trials addressing these issues were carried out. Three electronic databases, included PubMed, Web of Science, and Cochrane Library, were searched...

Cranio-Maxillofacial Surgery

2d

Azithromycin and Erythromycin susceptibility and macrolide resistance genes in Prevotella from patients with periodontal disease

Abstract Objectives To study oral Prevotella spp. isolated from patients with chronic periodontitis, to determine their susceptibility to azithromycin and erythromycin and to screen the presence of macrolide resistance genes therein. Material and Methods Isolates with a Prevotella‐like morphology were obtained from subgingival samples of 52 patients with chronic periodontitis. Each isolate was identified to the species level by sequencing of the 16S rRNA gene. In 100 Prevotella spp. isolates,...

Oral Diseases

2d

Clinical Evaluation of Full‐arch Screw‐Retained Implant‐Supported Fixed Prostheses and Full‐arch Telescopic‐Retained Implant‐Supported Fixed Prostheses: A 5–12 Year Follow‐up Retrospective Study

Abstract Objective To assess the prostheses and implants survival rate and peri‐implantitis rate in edentulous patients treated with full‐arch screw‐retained implant‐supported fixed dental prostheses (FSIFDPs) and full‐arch telescopic‐retained implant‐supported fixed dental prostheses (FTIFDPs) over an observation period of at least 5 years. Materials and Methods From 2004 to 2012, 696 implants were inserted into 78 patients with 102 prostheses. The FSIFDP group comprised 31 patients (37...

Clinical Oral Implants Research

2d

Maxillary osteotomy complications in piezoelectric surgery compared to conventional surgical techniques: a systematic review

Publication date: Available online 21 January 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): C. Thereza-Bussolaro, J. Galván Galván, C. Pachêco-Pereira, C. Flores-MirAbstractA systematic review was conducted to investigate the available evidence on maxillary complications related to piezoelectric and conventional surgery. Seven databases were searched. A total of 996 maxillary osteotomies were analysed, 864 performed with conventional tools and 132 with a piezoelectric...

Oral and Maxillofacial Surgery

2d

Maxillary osteotomy complications in piezoelectric surgery compared to conventional surgical techniques: a systematic review

A systematic review was conducted to investigate the available evidence on maxillary complications related to piezoelectric and conventional surgery. Seven databases were searched. A total of 996 maxillary osteotomies were analysed, 864 performed with conventional tools and 132 with a piezoelectric device. One hundred and fifty-six complication events were reported. The complications, in descending order of overall prevalence, were as follows: neurosensory disturbance (64.7%), haemorrhage (8.3%),...

Oral & Maxillofacial Surgery

2d

Effect of antiangiogenic targeted chemotherapy on the osseointegration of titanium implants in rabbits

Patients with cancer have recently been treated with more advanced targeted chemotherapies that have greater specificity towards the cancer cells and fewer side effects. However, the periods of treatment take longer than those of traditional cytotoxic treatments. The aim of this study was to examine the effect of antiangiogenic targeted chemotherapy on the osseointegration of titanium implants. Fourteen white New Zealand rabbits were allocated randomly into two groups of seven: the placebo control...

Oral and Maxillofacial Surgery

2d

World Workshop on Oral Medicine VII: Biomarkers predicting lymphoma in the salivary glands of patients with Sjögren's syndrome. A systematic review

Abstract Objective To conduct a systematic review of studies exploring potential biomarkers for development, course and efficacy of treatment of lymphomas in salivary glands of patients with Sjögren's syndrome. Material and Methods Eligible studies were identified through a comprehensive search of two databases, i.e. PubMed and EMBASE. Quality of included articles was assessed with the 'Quality In Prognosis Studies' (QUIPS) tool. The 'CHecklist for critical Appraisal and data extraction...

Oral Diseases

2d

Atraumatic restorative treatment—ART in early childhood caries in babies: 4 years of randomized clinical trial

Abstract Objective To assess the effectiveness of atraumatic restorative treatment (ART) performed 4 years ago in babies suffering from early childhood caries (ECC), and to compare the clinical performance of ART atraumatic restorations performed with two different high-viscosity glass ionomer cements (GIC). Materials and methods This was a longitudinal follow-up...

Clinical Oral Investigations

2d

Changes in proinflammatory gene expression in human whole blood after contact with UV-conditioned implant surfaces

Abstract Objectives The aim of this in vitro study was to assess changes in the gene expression of proinflammatory cytokines in human whole blood after contact with titanium implant surfaces conditioned by UV light. To this end, expression levels of proinflammatory cytokines were analyzed in vitro in human whole blood. Materials and methods Dental implants...

Clinical Oral Investigations

3d