Impact of Fluorine Substituents on π-Conjugated Polymer Main-Chain Conformations, Packing, and Electronic Couplings
[image: Thumbnail image of graphical abstract] *Taking the π-conjugated polymers PBDT[2X]T (X = H, F) as model systems*, the effects of fluorine substitution on main-chain conformations, packing, and electronic couplings are examined. Our combination of molecular dynamics simulations and solid-state NMR shows that a higher propensity for backbone planarity in PBDT[2F]T leads to more pronounced, yet staggered, chain stacking, which generally leads to higher electronic couplings and binding energy between neighboring chains. from Biomedical Engineering via xlomafota13 on Inoreader ... περισσότερα »
Fracture resistance of implant-supported screw-retained zirconia-based molar restorations
Abstract Objectives The objective of this *in vitro* study was to investigate fracture loads of screw-retained zirconia-based molar restorations (hybrid abutment crown) fabricated with different restorative materials and designs. Material and methods Forty-four screw-retained zirconia-based molar restorations were fabricated on dental implants and divided into four groups (*n *= 11): porcelain-layered zirconia-based restorations (PLZ), indirect composite-layered zirconia-based restorations (ILZ), metal–ceramic restorations (MC), and monolithic zirconia restorations (MONO). The z... περισσότερα »
MAK- und BAT-Werte-Liste 2016
[image: 3527342184.jpg] [image: rsstrack.gif?Section=RSS_WILEY2_MED&Page] Read More... http://ift.tt/29RpSKh
In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8
Abstract Background In myotonic dystrophy type 1 (DM1), only one FDG-PET study used statistical parametric mapping (SPM) showing frontal reduced FDG-uptake. Our aim was to 1) identify the FDG-PET area with the most severe reduced FDG-uptake using SPM8 in a larger group of patients 2) assess potential correlation between CTG-numbers and FDG-PET. Methods FDG-PET was performed in 24 patients and compared to 24 controls. Pearson's correlation was used to analyse correlation. Results SPM8 revealed Brodmann area 8 as the area with the most severe reduced FDG-uptake. Weak, although not... περισσότερα »
Determinants of stigma in a cohort of hellenic patients suffering from multiple sclerosis: a cross-sectional study
Abstract Background Patients suffering from several neurologic disorders may bear the "stigma" of their disease, being disqualified from full social acceptance. Although stigma is considered to be present in Multiple Sclerosis (MS), the factors that influence its levels are ambiguous. Aim of our study was to examine, for the first time in the literature, the basic determinants of stigma in a Hellenic MS-patients cohort, as well as how stigma affects their Quality-of-Life (QoL) profiles. Methods Three hundred forty two patients were recruited in this study. Data collected concerne... περισσότερα »
International Journal of Pediatric Otorhinolaryngology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
Follow-up care after grommet insertion in children: Review article Full Text References PDF (220 KB) Email Article Add to My Reading List Export Citation Create Citation Alert Cited by in Scopus (0) Request Permissions Order Reprints(100 minimum order) Zahir Mughal , Vijay Thirunavukarasu , Adnan Darr , Mudit Jindal International Journal of Pediatric Otorhinolaryngology, Volume […]
International Journal of Pediatric Otorhinolaryngology 48 citation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
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Ppediatric aspiration,Chiari malformations
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
Chiari malformations: An important cause of pediatric aspiration Jennifer C. Fuller , Sumi Sinha , Paul A. Caruso , Cheryl J. Hersh , William E. Butler , Kalpathy S. Krishnamoorthy , Christopher J. Hartnick DOI: http://ift.tt/29RxJdK Abstract Chronic aspiration poses a major health risk to the pediatric population. We describe four cases in which work up […]
Pediatric TORS for lingual thyroglossal duct cyst
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
The feasibility of ☆ Daniel J. Carroll , James K. Byrd , George F. Harris Department of Otolaryngology, Augusta University, Augusta, GA, USA DOI: http://ift.tt/2abn5uq Abstract A six-year-old boy who presented with symptoms of obstructive sleep apnea was found to have a midline tongue mass suspicious for lingual thyroglossal duct cyst (TGDC). Surgery was scheduled after […]
Obstructive congenital granular cell epulis (CGCE) : A Neonate with a solid tumor mass in the maxillary anterior ridge of the edentulous jaw
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
A study of cell proliferation using immunohistological staining: A case report of congenital granular cell epulis Bo Zhang , Xiaodan Tan , Kunlun Zhang , Yanchun Li , Jingjing Chen , Feng Zhang DOI: http://ift.tt/2abngFV Abstract An unusual case of a 1-day-old Chinese female neonate with a solid tumor mass in the maxillary anterior ridge of […]
Radiologically-guided balloon sialoplasty for treatment of salivary duct stricture
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
: A novel technique in young children Miles Bannister , Moti M. Chowdhury , Alok Sharma DOI: http://ift.tt/2abmsB1 Abstract Objectives To describe our experience using radiologically-guided balloon sialoplasty to successfully treat sialadenitis in two children as a single modality intervention. Methods A retrospective case series. Results Both children were successfully treated using balloon sialoplasty with complete […]
Two LTF non-synonymous polymorphisms, called Thr29Ala and Arg47Lys might not be involved in recurrent tonsillitis development
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
Lactoferrin gene polymorphisms in Italian patients with recurrent tonsillitis Luisa Zupin , Francesco Angelelli , Domenico Leonardo Grasso , Sergio Crovella DOI: http://ift.tt/2abnr47 Abstract Introduction Recurrent tonsillitis is an oral pathology characterized by inflammation of tonsils. The disease susceptibility depends upon environmental and host factors, specifically the innate immune response, the first line of host defence […]
Role of group 3 innate lymphoid cells during experimental otitis media
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
in a rat model☆ Chang Gun Cho , Sung Ho Gong , Hee-Bok Kim , Jae-Jun Song , Joo Hyun Park , Yun-Sung Lim , Seok-Won Park DOI: http://ift.tt/29G5zQk Abstract The objective of this study was to evaluate the role of group 3 innate lymphoid cells (ILC3) in the middle ear (ME) mucosal response to bacterial […]
Botulinum toxin injections for chronic sialorrhoea in children
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
are effective regardless of the degree of neurological dysfunction: A single tertiary institution experience Murali Mahadevan , Maayan Gruber , Darin Bilish , Kathryn Edwards , David Davies-Payne , Graeme van der Meer DOI: http://ift.tt/29G6i3V Abstract Objective To determine the effectiveness of submandibular salivary gland Botulinum Toxin Type-A (BTX-A) injection in the treatment of drooling in […]
Children with cochlear implant
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα
Evaluation on health-related quality of life in deaf children with cochlear implant in China Hong Liu , Hong-Xiang Liu , Hou-Yong Kang , Zheng Gu , Su-Ling Hong Department of Otorhinolaryngology, Chongqing Cancer Institute, 181# Hanyu Road, Shapingba District, 400030, People’s Republic of China DOI: http://ift.tt/2abmwkk Abstract Objective Previous studies have shown that deaf children benefit considerably […]
A Case Series: Outcomes of Endoscopic Biliary Self-Expandable Metal Stent for Malignant Biliary Obstruction with Surgically Altered Anatomy
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 17 δευτερόλεπτα
Abstract Background Few studies have reported the outcomes of self-expandable metal stent (SEMS) placement for malignant biliary obstruction in patients with surgically altered anatomy. Aims To evaluate the outcomes of biliary metal stent placement with the use of a short-type single-balloon enteroscope (working length, 1520 mm; channel diameter, 3.2 mm) in such patients. Methods We retrospectively studied 13 malignant biliary obstructions treated by SEMS placement. Technical success rate, functional success rate, time to recurrent biliary obstruction (RBO), and complications we... περισσότερα »
Peri-movement decrease of alpha-/beta-oscillations in the human nucleus accumbens
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 17 δευτερόλεπτα
The human nucleus accumbens is thought to play an important role in guiding future action selection via an evaluation of current action outcomes. Here, we provide electrophysiological evidence for a more direct, i.e., on-line, role during action preparation. We recorded local field potentials from the nucleus accumbens in patients with epilepsy undergoing surgery for deep brain stimulation. We found a consistent decrease in the power of alpha-/beta-oscillations (10 to 30 Hz) before and around the time of movements. This peri-movement alpha-/beta-desynchronization was observed in s... περισσότερα »
Velocity-dependence of Vestibular Information for Postural Control on Tilting Surfaces
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 17 δευτερόλεπτα
Vestibular information is known to be important for postural stability on tilting surfaces, but the relative importance of vestibular information across a wide range of surface tilt velocities is less clear. We compared how tilt velocity influences postural orientation and stability in 9 subjects with bilateral vestibular loss and 9 age-matched, control subjects. Subjects stood on a force platform that tilted 6 degrees, toes-up at eight velocities (0.25-32 deg/s), with and without vision. Results showed that visual information effectively compensated for lack of vestibular informa... περισσότερα »
GI-Safer Aspirin: Sometimes Sugar Coating Helps
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 17 δευτερόλεπτα
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Spike Synchrony Generated by Modulatory Common Input through NMDA-type Synapses
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 17 δευτερόλεπτα
Common excitatory input to neurons increases their firing rates and the strength of the spike correlation (synchrony) between them. Little is known, however, about the synchronizing effects of modulatory common input. Here we show that modulatory common input with the slow synaptic kinetics of NMDA receptors enhances firing rates and also produces synchrony. Tight synchrony (correlations on the order of milliseconds) always increases with modulatory strength. Unexpectedly, the relationship between strength of modulation and strength of loose synchrony (tens of milliseconds) is not ... περισσότερα »
Knockdown of Immature Colon Carcinoma Transcript 1 Inhibits Proliferation and Promotes Apoptosis of Non-Small Cell Lung Cancer Cells
Non–small cell lung cancer, as the most frequent type lung cancer, has lower survival rate of 5 years, despite improvements in surgery and chemotherapy. Previous studies showed immature colon carcinoma transcript 1 is closely related to tumorigenesis of human cancer cells. In the present study, we found immature colon carcinoma transcript 1 was overexpressed in lung cancer tissues using Oncomine database mining, and the biological effect of immature colon carcinoma transcript 1 was investigated in non–small cell lung cancer cell lines 95D and A549. Lentivirus-mediated RNA interfer... περισσότερα »
Assessment of efficacy, safety, and tolerability of 4-n-butylresorcinol 0.3% cream: an Indian multicentric study on melasma
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Spectrum of autoimmune vesiculobullous diseases in Iran: a 13-year retrospective study
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Radiesse®: a novel rejuvenation treatment for the upper arms
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Prevalence of acute and chronic viral seropositivity and characteristics of disease in patients with psoriatic arthritis treated with cyclosporine: a post hoc analysis from a sex point of view on the observational study of infectious events in psoriasis complicated by active psoriatic arthritis
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Phosphatidylcholine liposomes as carriers to improve topical ascorbic acid treatment of skin disorders
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Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant
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Letter: risk factor and mortality of peptic ulcer disease – authors′ reply
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Letter: cardiovascular complications in patients with transjugular intrahepatic portosystemic shunt – the necessity for regular cardiac surveillance. Authors' reply
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Letter: cardiovascular complications in patients with transjugular intrahepatic portosystemic shunt – the necessity for regular cardiac surveillance
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Letter: risk factors and impacts of psychological morbidity in young people with inflammatory bowel disease – authors’ reply
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Letter: risk factors and impacts of psychological morbidity in young people with inflammatory bowel disease
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Letter: risk factor and mortality of peptic ulcer disease
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Dental caries risk indicators in early childhood and their association with caries polarization in adolescence: a cross-sectional study
Abstract Background Based on the hypothesis that biological and social risks accumulate during life, it is important to identify possible dental caries risk indicators from the life course of early childhood and assess their association with caries polarization in adolescence. Methods A cross-sectional design was applied to the study, and a multistage cluster sampling method… Continue reading Dental caries risk indicators in early childhood and their association with caries polarization in adolescence: a cross-sectional study
Low Expression LncRNA TUBA4B is a Poor Predictor of Prognosis and Regulates Cell Proliferation in Non-Small Cell Lung Cancer
Abstract We aimed to unveil the clinical roles and biological function of lncRNA TUBA4B in on-small cell lung cancer (NSCLC). The relative expression level of TUBA4B was estimated by qPCR in 114 pairs of NSCLC and NT samples and the relation of TUBA4B to clinical data of NSCLC patients was analyzed. We found TUBA4B was… Continue reading Low Expression LncRNA TUBA4B is a Poor Predictor of Prognosis and Regulates Cell Proliferation in Non-Small Cell Lung Cancer
The Expression of Checkpoint and DNA Repair Genes in Head and Neck Cancer as Possible Predictive Factors
Abstract DNA damage response failure may influence the efficacy of DNA-damaging treatments. We determined the expression of 16 genes involved in distinct DNA damage response pathways, in association with the response to standard therapy. Twenty patients with locoregionally advanced, squamous cell head and neck carcinoma were enrolled. The treatment included induction chemotherapy (iChT) with docetaxel,… Continue reading The Expression of Checkpoint and DNA Repair Genes in Head and Neck Cancer as Possible Predictive Factors
Biologic Evaluation of Diabetes and Local Recurrence in Non-Small Cell Lung Cancer
Abstract A recent multicenter study led by our institution demonstrated that local recurrence of non-small cell lung cancer (NSCLC) was significantly more frequent in patients with diabetes, raising the possibility of different tumor biology in diabetics. Epithelial-to-mesenchymal transition (EMT) plays a key role in local tumor recurrence and metastasis. In the present study, we investigated… Continue reading Biologic Evaluation of Diabetes and Local Recurrence in Non-Small Cell Lung Cancer
Letter: risk factors and impacts of psychological morbidity in young people with inflammatory bowel disease
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Letter: risk factor and mortality of peptic ulcer disease
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Smoking is a risk factor for development of adult T-cell leukemia/lymphoma in Japanese human T-cell leukemia virus type-1 carriers
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 44 δευτερόλεπτα
Abstract Background and purpose Adult T-cell leukemia/lymphoma (ATLL) is an aggressive hematological malignancy caused by human T-cell leukemia virus type-1 (HTLV-1); no effective methods have yet been identified to prevent development of ATLL in carriers of HTLV-1. This study investigated the association between cigarette smoking and the risk of ATLL development among Japanese carriers of HTLV-1. Methods This study examined the association between smoking and development of ATLL in a cohort of 1,332 Japanese HTLV-1 carriers aged 40–69 years free of ATLL at baseline from two diff... περισσότερα »
Regulating CAR T Cells: A Remote Control Approach [News in Brief]
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 44 δευτερόλεπτα
Small-molecule adaptors that bridge CAR T cells and tumors trigger immunotherapeutic activity. from Cancer via xlomafota13 on Inoreader http://ift.tt/29ECdVh via IFTTT http://ift.tt/29EG84z
Biologic Evaluation of Diabetes and Local Recurrence in Non-Small Cell Lung Cancer
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 44 δευτερόλεπτα
Abstract A recent multicenter study led by our institution demonstrated that local recurrence of non-small cell lung cancer (NSCLC) was significantly more frequent in patients with diabetes, raising the possibility of different tumor biology in diabetics. Epithelial-to-mesenchymal transition (EMT) plays a key role in local tumor recurrence and metastasis. In the present study, we investigated differences of tumor microenvironment between patients with and without diabetes by examining expression of EMT markers. Seventy-nine NSCLC patients were selected from the cohort of our early ... περισσότερα »
Halitosis in children with adenoid vegetation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
An objective assessment of halitosis in children with adenoid vegetation during pre- and post-operative period Mehmet Emre Dinc , Aytug Altundag , Denizhan Dizdar , Mehmet Ozgur Avincsal , Ethem Sahin , Seckin Ulusoy , Ceki Paltura DOI: http://ift.tt/29EFyUc Abstract Objectives Although most specialists in otorhinolaryngology and pediatrics find halitosis to be a common problem in […]
The Effect Of Nigella sativa Oil On Prevention Of Myringosclerosis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
The Effect Of Nigella sativa Oil On Prevention Of Myringosclerosis In A Guinea Pig Model: Abstract Objectives In this study, our aim was to identify the possible effects of Nigella sativa L. (NS) [blackcumin] seed oil on the prevention of experimentally induced myringosclerosis (MS). Materials and methods Fourteen Guinea pigs were used and they were divided into […]
Should obtaining a preoperative audiogram before tympanostomy tube placement be used as a quality metric
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
? A survey of pediatric otolaryngologists Nikhila Raol , Christopher J. Hartnick , Joel S. Weissman DOI: http://ift.tt/29Fhfle Abstract Introduction Obtaining a preoperative audiogram prior to tympanostomy tube placement is recommended by the American Academy of Otolaryngology-Head and Neck Surgery clinical practice guideline (CPG):Tympanostomy tubes in Children, and this process measure is also used as a […]
Factors contributing to hearing impairment in patients with cleft lip/palate
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
in Malaysia: A prospective study of 346 ears Jack Pein Cheong , Siew Shuin Soo , Anura Michelle Manuel Department of Otorhinolaryngology, Faculty of Medicine, University Malaya, Lembah Pantai, 50603 Kuala Lumpur, Malaysia DOI: http://ift.tt/29ylrST Abstract Objective To determine the factors contributing towards hearing impairment in patients with cleft lip/palate. Method A prospective analysis was conducted […]
Paroxysmal vertigo with nystagmus in children
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
Paroxysmal vertigo with nystagmus in children: Abstract Introduction A pathological nystagmus is an objective sign that a patient feels vertigo. However, there have been few opportunities to observe and record pathological nystagmus during a paroxysmal vertigo attack. Furthermore, it can be difficult to obtain cooperation in pediatric patients. We present two cases of paroxysmal vertigo […]
Mesenchymal Stromal/Stem Cells Do Not Ameliorate Experimental Autoimmune Encephalomyelitis and Are Not Detectable in the Central Nervous System of Transplanted Mice
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/29TLTrx via IFTTT
Biologic Evaluation of Diabetes and Local Recurrence in Non-Small Cell Lung Cancer
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Abstract A recent multicenter study led by our institution demonstrated that local recurrence of non-small cell lung cancer (NSCLC) was significantly more frequent in patients with diabetes, raising the possibility of different tumor biology in diabetics. Epithelial-to-mesenchymal transition (EMT) plays a key role in local tumor recurrence and metastasis. In the present study, we investigated differences of tumor microenvironment between patients with and without diabetes by examining expression of EMT markers. Seventy-nine NSCLC patients were selected from the cohort of our early ... περισσότερα »
A novel multivariate STeady-state index during general ANesthesia (STAN)
Abstract The assessment of the adequacy of general anesthesia for surgery, namely the nociception/anti-nociception balance, has received wide attention from the scientific community. Monitoring systems based on the frontal EEG/EMG, or autonomic state reactions (e.g. heart rate and blood pressure) have been developed aiming to objectively assess this balance. In this study a new multivariate indicator of patients' steady-state during anesthesia (STAN) is proposed, based on wavelet analysis of signals linked to noxious activation. A clinical protocol was designed to analyze precise n... περισσότερα »
Binaural Glimpses at the Cocktail Party?
ABSTRACT Humans often have to focus on a single target sound while ignoring competing maskers in everyday situations. In such conditions, speech intelligibility (SI) is improved when a target speaker is spatially separated from a masker (spatial release from making, SRM) compared to situations where both are co-located. Such asymmetric spatial configurations lead to a 'better-ear effect' with improved signal-to-noise ratio (SNR) at one ear. However, maskers often surround the listener leading to more symmetric configurations where better-ear effects are absent in a long-term, wide... περισσότερα »
Differential effect of treadmill exercise on histone deacetylase activity in rat striatum at different stages of development
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract The study described herein aimed to evaluate the impact of exercise on histone acetylation markers in striatum from Wistar rats at different stages of development. Male Wistar rats were submitted to two different exercise protocols: a single session of treadmill (running 20 min) or a moderate daily exercise protocol (running 20 min for 2 weeks). Striata of rats aged 39 days postnatal (adolescents), 3 months (young adults), and 20 months (aged) were used. The single exercise session induced persistent effects on global HDAC activity only in the adolescent group, given that ... περισσότερα »
Energetics of muscle contraction: further trials
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract Knowledge accumulated in the field of energetics of muscle contraction has been reviewed in this article. Active muscle converts chemical energy into heat and work. Therefore, measurements of heat production and mechanical work provide the framework for understanding the process of energy conversion in contraction. In the 1970s, precise comparison between energy output and the associated chemical reactions was performed. It has been found that the two do not match in several situations, resulting in an energy balance discrepancy. More recently, efforts in resolving these ... περισσότερα »
Alectinib for ALK-Positive Non-Small Cell Lung Cancer
On December 11, 2015, the FDA granted accelerated approval to alectinib (ALECENSA®; Genentech, Inc.) for the treatment of patients with anaplastic lymphoma receptor tyrosine kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. This approval was based on two single-arm trials including 225 patients treated with alectinib… Continue reading Alectinib for ALK-Positive Non-Small Cell Lung Cancer
Low Expression LncRNA TUBA4B is a Poor Predictor of Prognosis and Regulates Cell Proliferation in Non-Small Cell Lung Cancer
Abstract We aimed to unveil the clinical roles and biological function of lncRNA TUBA4B in on-small cell lung cancer (NSCLC). The relative expression level of TUBA4B was estimated by qPCR in 114 pairs of NSCLC and NT samples and the relation of TUBA4B to clinical data of NSCLC patients was analyzed. We found TUBA4B was… Continue reading Low Expression LncRNA TUBA4B is a Poor Predictor of Prognosis and Regulates Cell Proliferation in Non-Small Cell Lung Cancer
Biologic Evaluation of Diabetes and Local Recurrence in Non-Small Cell Lung Cancer
Abstract A recent multicenter study led by our institution demonstrated that local recurrence of non-small cell lung cancer (NSCLC) was significantly more frequent in patients with diabetes, raising the possibility of different tumor biology in diabetics. Epithelial-to-mesenchymal transition (EMT) plays a key role in local tumor recurrence and metastasis. In the present study, we investigated… Continue reading Biologic Evaluation of Diabetes and Local Recurrence in Non-Small Cell Lung Cancer
WNT4 mediates the autocrine effects of growth hormone in mammary carcinoma cells
The expression of Wingless and Int-related protein (Wnt) ligands is aberrantly high in human breast cancer. We report here that WNT4 is significantly upregulated at the mRNA and protein level in mammary carcinoma cells expressing autocrine human growth hormone (hGH). Depletion of WNT4 using small interfering (si) RNA markedly decreased the rate of human breast… Continue reading WNT4 mediates the autocrine effects of growth hormone in mammary carcinoma cells
The Expression of Checkpoint and DNA Repair Genes in Head and Neck Cancer as Possible Predictive Factors
Abstract DNA damage response failure may influence the efficacy of DNA-damaging treatments. We determined the expression of 16 genes involved in distinct DNA damage response pathways, in association with the response to standard therapy. Twenty patients with locoregionally advanced, squamous cell head and neck carcinoma were enrolled. The treatment included induction chemotherapy (iChT) with docetaxel,… Continue reading The Expression of Checkpoint and DNA Repair Genes in Head and Neck Cancer as Possible Predictive Factors
Ki-67 index and response to chemotherapy in patients with neuroendocrine tumours
Chemotherapy (CT) is widely used for neuroendocrine tumours (NETs), but there are no validated biomarkers to predict response. The Ki-67 proliferation index has been proposed as a means of selecting patients for CT, but robust data are lacking. The aim of this study was to investigate the relationship between response to chemotherapy and Ki-67 in… Continue reading Ki-67 index and response to chemotherapy in patients with neuroendocrine tumours
Lymphovascular invasion is associated with survival for papillary thyroid cancer
Data are limited regarding the association between tumor lymphovascular invasion and survival for patients with papillary thyroid cancer (PTC). This study sought to examine lymphovascular invasion as an independent prognostic factor for patients with PTC undergoing thyroid resection. The National Cancer Data Base (2010–2011) was queried for patients with PTC who underwent total thyroidectomy or… Continue reading Lymphovascular invasion is associated with survival for papillary thyroid cancer
Alectinib for ALK-Positive Non-Small Cell Lung Cancer
On December 11, 2015, the FDA granted accelerated approval to alectinib (ALECENSA®; Genentech, Inc.) for the treatment of patients with anaplastic lymphoma receptor tyrosine kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. This approval was based on two single-arm trials including 225 patients treated with alectinib… Continue reading Alectinib for ALK-Positive Non-Small Cell Lung Cancer
Growing burden of sepsis-related mortality in northeastern Italy: a multiple causes of death analysis
Few population-based data are available on mortality due to sepsis. The aim of the study was to estimate sepsis-related mortality rates and to assess the associated comorbidities. from Infection via ola Kala on Inoreader http://ift.tt/29Ey2J4 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29FbtQs via IFTTT
Travelers’ health problems and behavior: prospective study with post-travel follow-up
The annual number of international tourist arrivals has recently exceeded one billion, yet surprisingly few studies have characterized travelers’ behavior, illness, and risk factors in a prospective setting. P… from Infection via ola Kala on Inoreader http://ift.tt/29FaShD via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29EybfD via IFTTT
Promoter Identification and Transcription Analysis of Penicillin-Binding Protein Genes in Streptococcus pneumoniae R6
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Microbial Drug Resistance , Vol. 0, No. 0. from Mary Ann Liebert, Inc. publishers via xlomafota13 on Inoreader http://ift.tt/29Ffm83 via IFTTT
WNT4 mediates the autocrine effects of growth hormone in mammary carcinoma cells
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The expression of Wingless and Int-related protein (Wnt) ligands is aberrantly high in human breast cancer. We report here that WNT4 is significantly upregulated at the mRNA and protein level in mammary carcinoma cells expressing autocrine human growth hormone (hGH). Depletion of WNT4 using small interfering (si) RNA markedly decreased the rate of human breast […]
Ki-67 index and response to chemotherapy in patients with neuroendocrine tumours
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Chemotherapy (CT) is widely used for neuroendocrine tumours (NETs), but there are no validated biomarkers to predict response. The Ki-67 proliferation index has been proposed as a means of selecting patients for CT, but robust data are lacking. The aim of this study was to investigate the relationship between response to chemotherapy and Ki-67 in […]
Lymphovascular invasion is associated with survival for papillary thyroid cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Data are limited regarding the association between tumor lymphovascular invasion and survival for patients with papillary thyroid cancer (PTC). This study sought to examine lymphovascular invasion as an independent prognostic factor for patients with PTC undergoing thyroid resection. The National Cancer Data Base (2010–2011) was queried for patients with PTC who underwent total thyroidectomy or […]
Practical Skin Cancer Surgery. Mileham Hayes Publisher: Elsevier, Australia, 2014; 316 pp. ISBN: 978-0-729-53932-6. Price £96·99.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29FYgIt via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
miR-145 mediated the role of aspirin in resisting VSMCs proliferation and anti-inflammation through CD40
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Aspirin (ASA) is the most widely used medicine to prevent cardiovascular diseases; however, the mechanisms by which ASA exerts its anti-proliferative effect remain not fully understood. This study was designed… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29PB1ML via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Erratum to: Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29zGeor via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Improved production of tannase by Klebsiella pneumoniae using Indian gooseberry leaves under submerged fermentation using Taguchi approach
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Tannase (tannin acyl hydrolase E.C 3.1.1.20) is an inducible, largely extracellular enzyme that causes the hydrolysis of ester and depside bonds present in various substrates. Large scale industrial applicatio… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29KvtCV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Anti-Estrogen Withdrawal Effect With Raloxifene? A Case Report
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
A 66-year-old patient presented with acute recurrent metastatic estrogen and progesterone receptor–positive, Her-2/neu-negative breast cancer, bone lesions (lumbar spine, pelvis), pulmonary nodules, hepatic metastasis, elevated cancer antigen 15 and liver enzymes, dyspepsia, and diarrhea. The patient had been taking raloxifene for approximately 8 years. After discontinuation, clinical parameters and symptoms improved rapidly without oncological therapy […]
Treatment of acromegaly increases BMD but reduces trabecular bone score: a longitudinal study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Context Bone turnover is increased in acromegaly. Despite normalization of bone turnover after treatment, the risk for vertebral fractures remains increased. Gonadal status, but not BMD, is correlated with vertebral fractures. Trabecular bone score (TBS) is related to bone microarchitecture. Objective The aim of this study is to assess the longitudinal change in TBS and […]
Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Objective Co-secretion of cortisol and aldosterone can be observed in adrenal adenomas. The aim of this study was to investigate the molecular characteristics of a co-existing aldosterone- and a cortisol-producing adenoma (CPA) in the same patient. Design and methods Two different adenomas within the same adrenal gland from a 49-year-old female patient with primary aldosteronism […]
Differential effect of treadmill exercise on histone deacetylase activity in rat striatum at different stages of development
Abstract The study described herein aimed to evaluate the impact of exercise on histone acetylation markers in striatum from Wistar rats at different stages of development. Male Wistar rats were submitted to two different exercise protocols: a single session of treadmill (running 20 min) or a moderate daily exercise protocol (running 20 min for 2 weeks). Striata of rats aged 39 days postnatal (adolescents), 3 months (young adults), and 20 months (aged) were used. The single exercise session induced persistent effects on global HDAC activity only in the adolescent group, given that ... περισσότερα »
Energetics of muscle contraction: further trials
Abstract Knowledge accumulated in the field of energetics of muscle contraction has been reviewed in this article. Active muscle converts chemical energy into heat and work. Therefore, measurements of heat production and mechanical work provide the framework for understanding the process of energy conversion in contraction. In the 1970s, precise comparison between energy output and the associated chemical reactions was performed. It has been found that the two do not match in several situations, resulting in an energy balance discrepancy. More recently, efforts in resolving these d... περισσότερα »
Dental caries risk indicators in early childhood and their association with caries polarization in adolescence: a cross-sectional study
Abstract Background Based on the hypothesis that biological and social risks accumulate during life, it is important to identify possible dental caries risk indicators from the life course of early childhood and assess their association with caries polarization in adolescence. Methods A cross-sectional design was applied to the study, and a multistage cluster sampling method used to draw a representative sample of 1063 18-year-old Lithuanian adolescents. The dental examinations were performed according to the methodology for oral status evaluation recommended by the World Health ... περισσότερα »
Ethnic differences in oral health and use of dental services: cross-sectional study using the 2009 Adult Dental Health Survey
Abstract Background Oral health impacts on general health and quality of life, and oral diseases are the most common non-communicable diseases worldwide. Non-White ethnic groups account for an increasing proportion of the UK population. This study explores whether there are ethnic differences in oral health and whether these are explained by differences in sociodemographic or lifestyle factors, or use of dental services. Methods We used the Adult Dental Health Survey 2009 to conduct a cross-sectional study of the adult general population in England, Wales and Northern Ireland. Et... περισσότερα »
Comparing the Efficiency of Two Different Extraction Techniques in Removal of Maxillary Third Molars: A Randomized Controlled Trial
Abstract Introduction Extractions are routine procedures in dental surgery. Traditional extraction techniques use a combination of severing the periodontal attachment, luxation with an elevator, and removal with forceps. A new technique of extraction of maxillary third molar is introduced in this study—Joedds technique, which is compared with the conventional technique. Methods and Material One hundred people were included in the study, the people were divided into two groups by means of simple random sampling. In one group conventional technique of maxillary third molar extractio... περισσότερα »
Development of Auxiliaries in Young Children Learning African American English
Purpose We examined language samples of young children learning African American English (AAE) to determine if and when their use of auxiliaries shows dialect-universal and dialect-specific effects. Method The data were longitudinal language samples obtained from two children, ages 18 to 36 months, and three children, ages 33 to 51 months. Dialect-universal analyses examined age of first form and early uses of BE, DO, and modal auxiliaries. Dialect-specific analyses focused on rates of overt marking by auxiliary type and syntactic construction and for BE by surface form and succeedi... περισσότερα »
Comparison of Videostroboscopy and High-speed Videoendoscopy in Evaluation of Supraglottic Phonation
Objectives: To compare clinicians' ratings of videolaryngoscopy (VLS) and high-speed videoendoscopy (HSV) and assess confidence of ratings with VLS and HSV in patients with supraglottic phonation. Methods: The VLS and HSV video samples were taken from 11 adolescents post airway reconstruction who use supraglottic tissues for voice. The 22 recordings were randomized and presented to 4 clinicians: 2 speech-language pathologists and 2 pediatric otolaryngologists. Additionally, a 5-point Likert scale was used to rate level of confidence of ratings. Results: Clinicians were more li... περισσότερα »
Theoretical Principles to Guide the Teaching of Adjectives to Children Who Struggle With Word Learning: Synthesis of Experimental and Naturalistic Research With Principles of Learning Theory
Purpose The purpose of this tutorial is to provide clinicians with a theoretically motivated and evidence-based approach to teaching adjectives to children who struggle with word learning. Method Given that there are almost no treatment studies to guide this topic, we have synthesized findings from experimental and theoretical literature to come up with a principles-based approach to treatment. Results We provide a sample lesson plan, incorporating our 3 theoretical principles, and describe the materials chosen and methods used during treatment and assessment. Conclusion This appro... περισσότερα »
Tinnitus Retraining Therapy Online
The high-pitched persistent whining of tinnitus can range from irritating to maddening for many people. It may make it difficult to hear conversations, or impossible to relax due to the constant sound in your ear. If you struggle with this condition, one therapy treatment that you can try at home is online tinnitus retraining therapy. What is Tinnitus? Tinnitus is a condition where you hear constant sounds, like whining or ringing, when no sound is present. Different cases have been shown to be linked to hearing loss, particularly when the cochlea, nerve cells or hair cells in the... περισσότερα »
Clinical Translation of Tissue Engineered Trachea Grafts
Objective: To provide a state-of-the-art review discussing recent achievements in tissue engineered tracheal reconstruction. Data Sources and Review Methods: A structured PubMed search of the current literature up to and including October 2015. Representative articles that discuss the translation of tissue engineered tracheal grafts (TETG) were reviewed. Conclusions: The integration of a biologically compatible support with autologous cells has resulted in successful regeneration of respiratory epithelium, cartilage, and vascularization with graft patency, although the optimal ... περισσότερα »
Description and Preliminary Evaluation of a Curriculum for Teaching Conversational Skills to Children With High-Functioning Autism and Other Social Cognition Challenges
Purpose The purpose of this clinical focus article is to provide (a) a detailed description of a school-based intervention designed to teach children with high-functioning autism spectrum disorders (HF-ASDs) and other social cognition challenges both the how and the why of conversation and (b) a preliminary evaluation of program outcomes. Method This pilot study involved (a) qualitative and quantitative analysis of video footage of participants' conversational skills at baseline, during intervention, and postintervention; (b) interviews with participants' speech-language pathologist... περισσότερα »
Taxonomic Knowledge of Children With and Without Cochlear Implants
Purpose The purpose of this study was to compare the taxonomic vocabulary knowledge and organization of children with cochlear implants to (a) children with normal hearing matched for age, and (b) children matched for vocabulary development. Method Ten children with cochlear implants, 10 age-matched children with normal hearing, and 10 vocabulary-matched children with normal hearing participated in this study. The children completed 2 experimental tasks: a forced-choice taxonomic sorting task, and a naming task requiring the children to use labels at multiple taxonomic levels. Resu... περισσότερα »
Use of Language Sample Analysis by School-Based SLPs: Results of a Nationwide Survey
Purpose This article examines use of language sample analysis (LSA) by school-based speech-language pathologists (SLPs), including characteristics of language samples, methods of transcription and analysis, barriers to LSA use, and factors affecting LSA use, such as American Speech-Language-Hearing Association certification, number of years' experience, and caseload characteristics. Method School-based SLPs responded to an invitation to complete an electronic survey related to LSA. Results One third of respondents indicated they did not use LSA during the 2012–2013 school year. SLP... περισσότερα »
Validating the Use of D for Measuring Lexical Diversity in Low-Income Kindergarten Children
Purpose Children from low–socioeconomic status families often perform poorly on standardized vocabulary assessments. The primary purpose of the study was to determine whether lexical diversity as measured by D (Malvern, Richards, Chipere, & Durán, 2004) serves as a valid measure of vocabulary in at-risk, low-income, predominantly African American kindergartners. Method Kane's (1992) argument-based approach was used to validate D. Six assumptions were examined. Kindergartners (N = 210) from a high-poverty, low-achievement region of the United States were recorded narrating a wordless... περισσότερα »
MSRP On Neuromonics Oasis
For those who experience tinnitus, the condition can be one that at times is debilitating. Constant ringing in the ears, along with swishing sounds or other sounds that become a tremendous distraction, can lead a person to wonder at times if things will ever get better. However, one of the most promising treatments is known as neuromonics oasis. Designed to relieve symptoms and help people once again maintain concentration and balance, this treatment can indeed help people once again regain control of their lives. MSRP on Neuromonics Oasis When patients are considering this treatm... περισσότερα »
Alectinib for ALK-Positive Non-Small Cell Lung Cancer
On December 11, 2015, the FDA granted accelerated approval to alectinib (ALECENSA®; Genentech, Inc.) for the treatment of patients with anaplastic lymphoma receptor tyrosine kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. This approval was based on two single-arm trials including 225 patients treated with alectinib 600 mg orally twice daily. The objective response rates (ORR) by independent review committee in these studies were 38% (95% CI, 36-52) and 44% (95% CI 36-53); the median durations of response (D... περισσότερα »
Low Expression LncRNA TUBA4B is a Poor Predictor of Prognosis and Regulates Cell Proliferation in Non-Small Cell Lung Cancer
Abstract We aimed to unveil the clinical roles and biological function of lncRNA TUBA4B in on-small cell lung cancer (NSCLC). The relative expression level of TUBA4B was estimated by qPCR in 114 pairs of NSCLC and NT samples and the relation of TUBA4B to clinical data of NSCLC patients was analyzed. We found TUBA4B was lower expressed in NSCLC and five cell lines. The lower expression of TUBA4B was remarkably correlated with advanced TNM stage and lymph node metastasis and served as a predictor for overall survival of NSCLC. After overexpression of TUBA4B, cell proliferation abilit... περισσότερα »
The Expression of Checkpoint and DNA Repair Genes in Head and Neck Cancer as Possible Predictive Factors
Abstract DNA damage response failure may influence the efficacy of DNA-damaging treatments. We determined the expression of 16 genes involved in distinct DNA damage response pathways, in association with the response to standard therapy. Twenty patients with locoregionally advanced, squamous cell head and neck carcinoma were enrolled. The treatment included induction chemotherapy (iChT) with docetaxel, cisplatin and 5-fluorouracil followed by concomitant chemoradiotherapy (ChRT) or radiotherapy (RT) alone. The volumetric metabolic therapeutic response was determined by [18F]FDG-PE... περισσότερα »
Biologic Evaluation of Diabetes and Local Recurrence in Non-Small Cell Lung Cancer
Abstract A recent multicenter study led by our institution demonstrated that local recurrence of non-small cell lung cancer (NSCLC) was significantly more frequent in patients with diabetes, raising the possibility of different tumor biology in diabetics. Epithelial-to-mesenchymal transition (EMT) plays a key role in local tumor recurrence and metastasis. In the present study, we investigated differences of tumor microenvironment between patients with and without diabetes by examining expression of EMT markers. Seventy-nine NSCLC patients were selected from the cohort of our early ... περισσότερα »
Theoretical Principles to Guide the Teaching of Adjectives to Children Who Struggle With Word Learning: Synthesis of Experimental and Naturalistic Research With Principles of Learning Theory
Purpose The purpose of this tutorial is to provide clinicians with a theoretically motivated and evidence-based approach to teaching adjectives to children who struggle with word learning. Method Given that there are almost no treatment studies to guide this topic, we have synthesized findings from experimental and theoretical literature to come up with a principles-based approach to treatment. Results We provide a sample lesson plan, incorporating our 3 theoretical principles, and describe the materials chosen and methods used during treatment and assessment. Conclusion This appro... περισσότερα »
Taxonomic Knowledge of Children With and Without Cochlear Implants
Purpose The purpose of this study was to compare the taxonomic vocabulary knowledge and organization of children with cochlear implants to (a) children with normal hearing matched for age, and (b) children matched for vocabulary development. Method Ten children with cochlear implants, 10 age-matched children with normal hearing, and 10 vocabulary-matched children with normal hearing participated in this study. The children completed 2 experimental tasks: a forced-choice taxonomic sorting task, and a naming task requiring the children to use labels at multiple taxonomic levels. Resu... περισσότερα »
Description and Preliminary Evaluation of a Curriculum for Teaching Conversational Skills to Children With High-Functioning Autism and Other Social Cognition Challenges
Purpose The purpose of this clinical focus article is to provide (a) a detailed description of a school-based intervention designed to teach children with high-functioning autism spectrum disorders (HF-ASDs) and other social cognition challenges both the how and the why of conversation and (b) a preliminary evaluation of program outcomes. Method This pilot study involved (a) qualitative and quantitative analysis of video footage of participants' conversational skills at baseline, during intervention, and postintervention; (b) interviews with participants' speech-language pathologist... περισσότερα »
Validating the Use of D for Measuring Lexical Diversity in Low-Income Kindergarten Children
Purpose Children from low–socioeconomic status families often perform poorly on standardized vocabulary assessments. The primary purpose of the study was to determine whether lexical diversity as measured by D (Malvern, Richards, Chipere, & Durán, 2004) serves as a valid measure of vocabulary in at-risk, low-income, predominantly African American kindergartners. Method Kane's (1992) argument-based approach was used to validate D. Six assumptions were examined. Kindergartners (N = 210) from a high-poverty, low-achievement region of the United States were recorded narrating a wordless... περισσότερα »
Development of Auxiliaries in Young Children Learning African American English
Purpose We examined language samples of young children learning African American English (AAE) to determine if and when their use of auxiliaries shows dialect-universal and dialect-specific effects. Method The data were longitudinal language samples obtained from two children, ages 18 to 36 months, and three children, ages 33 to 51 months. Dialect-universal analyses examined age of first form and early uses of BE, DO, and modal auxiliaries. Dialect-specific analyses focused on rates of overt marking by auxiliary type and syntactic construction and for BE by surface form and succeedi... περισσότερα »
Structure Dependence of Lysosomal Transit of Chitosan-Based Polyplexes for Gene Delivery
Abstract Chitosan-based polyplexes are known to traffic through lysosomes for a relatively long time, independent of the degree of deacetylation (DDA) and the number average molecular weight (Mn) of the polymer, even though both of these parameters have profound effects on polyplex stability and transfection efficiency. A better understanding of the lysosomal barrier is paramount to the rational design of vectors capable of overcoming obstacles to transgene expression. The aim of the present study was to investigate if lysosomal transit affects chitosan-based polyplex transfection ... περισσότερα »
Articulated Clinician Detection Using 3D Pictorial Structures on RGB-D Data
Publication date: Available online 11 July 2016 *Source:*Medical Image Analysis Author(s): Abdolrahim Kadkhodamohammadi, Afshin Gangi, Michel de Mathelin, Nicolas Padoy Reliable human pose estimation (HPE) is essential to many clinical applications, such as surgical workflow analysis, radiation safety monitoring and human-robot cooperation. Proposed methods for the operating room (OR) rely either on foreground estimation using a multi-camera system, which is a challenge in real ORs due to color similarities and frequent illumination changes, or on wearable sensors or markers, which ... περισσότερα »
