Ventricular fibrillation resulting from electrolyte imbalance reveals vipoma in MEN1 syndrome
Ventricular fibrillation resulting from electrolyte imbalance reveals vipoma in MEN1 syndrome: AbstractSporadic VIPoma is an exceedingly rare tumor with an annual incidence of 1:10 million people worldwide, yet it is described in approximately 5 % of MEN1 patients. The majority of VIPomas are malignant and radical surgery is the best therapeutic option. A 58-year-old man presented with cardiocirculatory arrest due to ventricular fibrillation. The patient had a 3-month history of epigastric pain with diarrhea. After reanimation, laboratory data revealed severe hypokalemia and hyperc... περισσότερα »
Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) : Minimal renal toxicity after Rituximab DHAP with a modified cisplatin application scheme
in patients with relapsed or refractory diffuse large B-cell lymphoma via http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=12885&channel-name=BMC+Cancer AbstractBackgroundRituximab (R) in combination with DHAP is a widely accepted salvage regimen for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). A common adverse effect of this protocol is renal toxicity which may result in treatment discontinuation. Assuming that a lower single dose of cisplatin over several days would reduce renal toxicity, our institution has chosen to ad... περισσότερα »
Extracranial malignant rhabdoid tumours (MRT)
Outcome of extracranial malignant rhabdoid tumours in children registered in the European Paediatric Soft Tissue Sarcoma Study Group Non-Rhabdomyosarcoma Soft Tissue Sarcoma 2005 Study—EpSSG NRSTS 2005 via ScienceDirect Publication: European Journal of Cancer Publication date: June 2016 *Source:*European Journal of Cancer, Volume 60 Author(s): Bernadette Brennan, Gian Luca De Salvo, Daniel Orbach, Angela De Paoli, Anna Kelsey, Peter Mudry, Nadine Francotte, Max Van Noesel, Gianni Bisogno, Michela Casanova, Andrea Ferrari BackgroundExtracranial malignant rhabdoid tumours (MRT) are rare l... περισσότερα »
Which Patients With Mantle Cell Lymphoma Do Not Need Aggressive Therapy
Which Patients With Mantle Cell Lymphoma Do Not Need Aggressive Therapy: AbstractMantle cell lymphoma (MCL) is a heterogeneous disease, and it has been well-established over the last decade that a subset of patients can have indolent presentation. It is therefore important to adopt a risk-stratified approach in order to minimize unnecessary toxicities while maximizing survival and quality of life in selected MCL patients. This review provides an up-to-date assessment of clinical and pathologic entities associated with indolent disease course and delineates available biomarkers with... περισσότερα »
Neutrophil-mediated tumor cell survival & extravasation
[Research Articles]: Immune cells promote the initial metastatic dissemination of carcinoma cells from primary tumors. In contrast to their well-studied functions in the initial stages of metastasis, the specific roles of immunocytes in facilitating progression through the critical later steps of the invasion-metastasis cascade remain poorly understood. Here we define novel functions of neutrophils in promoting intraluminal survival and extravasation at sites of metastatic dissemination. We show that CD11b+/Ly6G+ neutrophils enhance metastasis formation via two distinct mechanism... περισσότερα »
Label-Free Neurosurgical Pathology with SRS imaging
Label-Free Neurosurgical Pathology with SRS imaging: The goal of brain tumor surgery is to maximize tumor removal without injuring critical brain structures. Achieving this goal is challenging since it can be difficult to distinguish tumor from non-tumor tissue. While standard histopathology provides information that could assist tumor delineation, it cannot be performed iteratively during surgery as freezing, sectioning, and staining of the tissue require too much time. Stimulated Raman scattering (SRS) microscopy is a powerful label-free chemical imaging technology that enables ra... περισσότερα »
NQO1-dependent radiosensitization of head and neck cancer
NQO1-dependent radiosensitization of head and neck cancer: Ionizing radiation (IR) is a key therapeutic regimen for many head and neck cancers (HNCs). However, the 5-year overall survival rate for locally-advanced HNCs is ~50% and better therapeutic efficacy is needed. NAD(P)H:quinone oxidoreductase 1 (NQO1) is over-expressed in many cancers, and β-lapachone (β-lap), an unique NQO1 bioactivatable drug, exploits this enzyme to release massive reactive oxygen species (ROS) levels that synergizes with IR to kill by programmed necrosis. β-Lap represents a novel therapeutic opportunity ...περισσότερα »
Self-Fitting Hearing Aids: Status Quo and Future Predictions
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
A self-contained, self-fitting hearing aid (SFHA) is a device that enables the user to perform both threshold measurements leading to a prescribed hearing aid setting and fine-tuning, without the need for audiological support or access to other equipment. The SFHA has been proposed as a potential solution to address unmet hearing health care in developing […]
Geopolymer based on concrete demolition waste
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Publication date: Available online 9 April 2016 Source:Advanced Powder Technology Author(s): Alexander Vásquez, Venus Cárdenas, Rafael A. Robayo, Ruby Mejía de Gutiérrez In the present study, the synthesis of geopolymers based on alkaline activation of concrete demolition waste (CDW) was investigated using sodium hydroxide and sodium silicate as alkaline activators. To produce hybrid and binary […]
Acute Ataxia in Childhood: 11-Year Experience at a Major Pediatric Neurology Referral Center
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
We categorized the causes of acute ataxia in the pediatric population—referred to the Division of Neurology—at a large, urban pediatric medical center. Of the 120 cases identified over the past 11 years, post-infectious cerebellar ataxia was the most commonly diagnosed (59%), followed by drug intoxication, opsoclonus-myoclonus ataxia syndrome, episodic ataxia, acute cerebellitis, cerebellar stroke, ADEM, […]
Imaging Findings in Pediatric Posterior Reversible Encephalopathy Syndrome (PRES): 5 Years of Experience From a Tertiary Care Center in India
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
This study sought to evaluate the radiological and clinical spectrum of posterior reversible encephalopathy syndrome (PRES) in pediatric population. A retrospective evaluation of the pediatric patients with posterior reversible encephalopathy syndrome seen over the last 5 years in the authors’ hospital was done. The magnetic resonance imaging (MRI) findings were analyzed, and a review of […]
Comorbid Medical Conditions in Friedreich Ataxia: Association With Inflammatory Bowel Disease and Growth Hormone Deficiency
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Friedreich ataxia is a progressive degenerative disease with neurologic and cardiac involvement. This study characterizes comorbid medical conditions in a large cohort of patients with Friedreich ataxia. Patient diagnoses were collected in a large natural history study of 641 subjects. Prevalence of diagnoses in the cohort with Friedreich ataxia was compared with prevalence in the […]
Stability of Pediatric Migraine Subtype After a 5-year Follow-Up
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
The study assessed the 5-year follow-up outcome and possible prognostic factors of migraine subtypes with onset in childhood or adolescence. A total of 343 patients meeting the International Classification of Headache Disorders (ICHD)-II criteria for migraine without aura (MO), migraine with aura (MA), or both MO+MA (ie, 1.1, 1.2) were contacted by phone and underwent […]
Whole-Body Vibration Results in Short-Term Improvement in the Gait of Children With Idiopathic Toe Walking
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
This study aimed to determine the impact of multiple doses of whole-body vibration on heel strike, spatial and temporal gait parameters, and ankle range of motion of children with idiopathic toe walking. Whole-body vibration was applied for 5 sets of 1 minute vibration/1 minute rest. Gait measures were collected pre intervention, 1, 5, 10, and […]
Conventional and Advanced Imaging of Diffuse Intrinsic Pontine Glioma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Diffuse intrinsic pontine glioma is the most common brainstem tumor in pediatric patients. This tumor remains one of the most deadly pediatric brain tumors. The diagnosis primarily relies on clinical symptoms and imaging findings. Conventional MRI provides a noninvasive accurate method of diagnosis of these tumors. Advanced MRI techniques are becoming more widely used and […]
A study of HLA-B(∗)1502 in a Sri Lankan Population: Implications for pharmacogenomic testing.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
This study was conducted to estimate the prevalence of HLA-B(*)1502 in a cohort of Sri Lankans. We observed an overall prevalence of 4.3% (4/93) among 93 Sri Lankans comprised of 32 Sinhalese, 30 Sri Lankan Tamils and 31 Moors. The allele was detected in 3 [9.3%; 3/32] Sinhalese, 0 [0%; 0/30] Sri Lankan Tamils and […]
Donor Specific Antibodies are not only directed against HLA-DR: minding your Ps and Qs.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Authors: Cross AR, Lion J, Loiseau P, Charron D, Taupin JL, Glotz D, Mooney N Abstract During solid organ transplantation, interactions between recipient and donor immune cells occur chiefly in the allograft microvasculature. All three HLA class II antigens, DR, DP and DQ, have been detected on renal EC with a markedly increased expression of […]
Outcome of a cohort of severe cerebral venous thrombosis in intensive care
Severity of cerebral venous thrombosis (CVT) may require the transfer to intensive care unit (ICU). This report described the context for CVT transfer to ICU, the strategy of care and the outcome after 1 year. from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1Wq6p5l via IFTTT
Topical liposomal azithromycin in the treatment of acute cutaneous leishmaniasis
Topical liposomal azithromycin in the treatment of acute cutaneous leishmaniasis: Abstract Cutaneous leishmaniasis (CL) treatment is based on pentavalant antimony (sbv) drugs which are accompanied by many side effects and are facing ever-increasing resistance. Topical treatment of CL is an attractive alternative avoiding toxicities of parenteral therapy while being administered through a simple painless route. The liposomal formulations of different drugs have recently been increasingly used in the treatment of several types of leishmaniasis. The efficacy of a topical liposomal az... περισσότερα »
Dysphagia and anorexia as presentations of leptomeningeal carcinomatosis
Dysphagia and anorexia as presentations of leptomeningeal carcinomatosis: A 61-year-old woman presented to the emergency department, with a 4-day history of isolated oropharyngeal dysphagia associated with anorexia and weight loss over the previous 4 weeks. She had no other focal neurological symptoms and no deficits on examination. She had been in a 4-year remission of breast cancer postmastectomy and chemoradiation. Neuroimaging showed enhancement of cranial nerves VII, VIII, cisternal segment of cranial V, dorsal and ventral surfaces of the cervical and thoracic cord as well as ...περισσότερα »
Can the careHPV test performed in mobile units replace cytology for screening in rural and remote areas?
Can the careHPV test performed in mobile units replace cytology for screening in rural and remote areas?: BACKGROUND Human papillomavirus (HPV) DNA testing can be crucial for women who have limited access to traditional screening. The current study compared the results obtained through HPV DNA testing with those obtained through cytology-based screening. METHODS A total of 3068 women aged 18 to 85 years were enrolled in an opportunistic cervical cancer screening program developed by the Barretos Cancer Hospital and performed by a team of health professionals working within a mobile ... περισσότερα »
The impact of gross anatomy laboratory on first year medical students' interest in a surgical career
The impact of gross anatomy laboratory on first year medical students' interest in a surgical career: Abstract *Introduction*: This study sought to determine the impact of gross anatomy laboratory on first year medical students' (M1) interest in a surgical career. Secondary objectives included identifying other influences in M1s' career decision making. *Materials and Methods*: This prospective study included surveys before and after gross anatomy laboratory (GA). All M1s enrolled in GA were invited to participate. Sixty students completed both the pre- and post-test surveys. A 5-p... περισσότερα »
Atemwegsmanagement – Vergleich verschiedener Leitlinien zum Management des schwierigen Atemwegs
Atemwegsmanagement – Vergleich verschiedener Leitlinien zum Management des schwierigen Atemwegs: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 244-252 DOI: 10.1055/s-0041-103155 Das Management des schwierigen Atemwegs hat aufgrund seiner Relevanz für das Outcome der Patienten einen hohen Stellenwert in der Fort- und Weiterbildung in der Anästhesie. Ein Algorithmus kann als Plan für eine schwierige Situation gesehen werden. Seit 1993 haben zahlreiche Fachgesellschaften Leitlinien zum Atemwegsmanagement herausgegeben. Die Leitlinien von ASA und DGAI haben neben vielen inha... περισσότερα »
Atemwegsmanagement – Weiterhin eine sehr gefährliche Angelegenheit!
Atemwegsmanagement – Weiterhin eine sehr gefährliche Angelegenheit!: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 242-243 DOI: 10.1055/s-0042-105183 Ein Albtraum für jeden Anästhesisten: Eine junge Patientin kommt in die Klinik für einen kleinen elektiven Eingriff. Aufgrund der Lagerung für den Eingriff wird die Patientin auf ein Anästhesieverfahren in Narkose aufgeklärt (Intubationsnarkose). Die Patientin ist ansonsten gesund und weist auch keine Anästhesiespezifischen Risiken auf (z. B. Atemweg). Nach Etablierung eines venösen Zugangs, Präoxygenierung und Einleitung de... περισσότερα »
Atemwegsmanagement – Tracheotomie Revisited
Atemwegsmanagement – Tracheotomie Revisited: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 264-272 DOI: 10.1055/s-0041-103154 Die Tracheotomie ist ein bereits seit 5000 Jahren durchgeführtes Verfahren zur Atemwegssicherung. Generell unterscheidet man zwei Verfahren, die perkutane Dilatationstracheotomie und die chirurgische Tracheotomie. Die chirurgische Tracheotomie wird im OP Saal durchgeführt. Die perkutane Dilatationstracheotomie zählt zu den Standardverfahren in der Intensivmedizin. Sie kann unter geeigneter Indikationsstellung und nach Ausschluss von Kontraindikati... περισσότερα »
Patienten mit implantierten Schrittmachern und / oder Defibrillatoren – Perioperatives Vorgehen
Patienten mit implantierten Schrittmachern und / oder Defibrillatoren – Perioperatives Vorgehen: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 220-225 DOI: 10.1055/s-0041-110322 Anästhesisten werden immer häufiger mit Patienten konfrontiert, die Schrittmacher oder Defibrillatoren implantiert haben. Das Handling solcher Patienten ist in einer Consensus Conference für den Elektivpatienten festgelegt worden, allerdings in einer für den klinischen Alltag und insbesondere für Notfälle nicht praktikablen multidisziplinären Komplexität. Die Risiken, die sich aus direkter Schädi...περισσότερα »
Atemwegsmanagement – Alternatives Atemwegsmanagement im Rettungsdienst
Atemwegsmanagement – Alternatives Atemwegsmanagement im Rettungsdienst: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 254-262 DOI: 10.1055/s-0041-103153 Die Atemwegssicherung ist speziell im Bereich der präklinischen Notfallmedizin eine besondere Herausforderung. Auch bei zahlreichen verfügbaren alternativen Hilfsmitteln gilt die endotracheale Intubation (ETI) weiterhin als „Goldstandard“. Limitierte Kenntnisse und Erfahrungen des Anwenders sind neben einem kritischen Patientenzustand, speziellen Umgebungsverhältnissen und begrenzten materiellen und personellenRessourcen ... περισσότερα »
School children at risk of anaphylaxis and rate of adrenaline autoinjector activation
Statewide prevalence of school children at risk of anaphylaxis and rate of adrenaline autoinjector activation in Victorian government schools, Australia via Allergy and Clinical Immunology Publication date: Available online 12 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Paxton Loke, Jennifer Koplin, Cara Beck, Michael Field, Shyamali C. Dharmage, Mimi L.K. Tang, Katrina J. Allen BackgroundThe prevalence of school students at risk of anaphylaxis in Victoria is unknown and has not been previously studied. Similarly, rates of adrenaline autoinjector usage in ... περισσότερα »
Aging: A Temporal Dimension for Neutrophils
Aging: A Temporal Dimension for Neutrophils via ScienceDirect Publication: Trends in Immunology Publication date: Available online 12 April 2016 *Source:*Trends in Immunology Author(s): José M. Adrover, José A. Nicolás-Ávila, Andrés Hidalgo Neutrophils are first-responders, providing early protection against invading pathogens. Recent findings have revealed a temporal dimension to neutrophil function, associated with the clearance cycles for aging neutrophils, and also with a program that endows circulating neutrophils with distinct phenotypic and functional properties at different tim... περισσότερα »
Asthmatic granulomatosis
Asthmatic granulomatosis: In the last decade, significant efforts have been made to identify the characteristics of severe asthma, which are different from those described in mild to moderate asthma. Currently, severe asthma is recognized as a heterogeneous disease,1 and asthma management is recommended to include the stratification of patients into the recently defined phenotypes (clinical, inflammatory, molecular)2 to offer a better therapeutic approach.
Human CD8+ T Cells Target Multiple Epitopes in Respiratory Syncytial Virus Polymerase
Human CD8+ T Cells Target Multiple Epitopes in Respiratory Syncytial Virus Polymerase: Viral Immunology , Vol. 0, No. 0. Author information Daniel Burbulla,1 Patrick S. Günther,1 Janet K. Peper,2 Gerhard Jahn,1 and Kevin M. Dennehy1 1Institute for Medical Virology, University Hospital Tübingen, Tübingen, Germany. 2Department of Immunology, University of Tübingen, Tübingen, Germany. Address correspondence to: *Dr. Kevin M. Dennehy* *Institut für Medizinische Virologie* *Universitätsklinikum Tübingen* *Elfriede-Aulhorn-Street 6* *Tübingen 72076* Germany *E-mail:* kevin-michael.dennehy@...περισσότερα »
Acellular reticular allogenic human dermis versus standard of care in the treatment of chronic diabetic ulcers
A prospective, randomised, controlled, multicentre clinical trial examining healing rates, safety and cost to closure of an Abstract Acellular dermal matrices can successfully heal wounds. This study's goal was to compare clinical outcomes of a novel, open-structure human reticular acellular dermis matrix (HR-ADM) to facilitate wound closure in non-healing diabetic foot ulcers (DFUs) versus DFUs treated with standard of care (SOC). Following a 2-week screening period in which DFUs were treated with offloading and moist wound care, patients were randomised to either SOC alone or HR-... περισσότερα »
Organotypic slice cultures of human gastric and esophagogastric junction cancer
Abstract Gastric and esophagogastric junction cancers are heterogeneous and aggressive tumors with an unpredictable response to cytotoxic treatment. New methods allowing for the analysis of drug resistance are needed. Here, we describe a novel technique by which human tumor specimens can be cultured ex vivo, preserving parts of the natural cancer microenvironment. Using a tissue… Continue reading Organotypic slice cultures of human gastric and esophagogastric junction cancer
Ecosystem Level Methane Fluxes from Tidal Freshwater and Brackish Marshes of the Mississippi River Delta: Implications for Coastal Wetland Carbon Projects
Abstract Sulfate from seawater inhibits methane production in tidal wetlands, and by extension, salinity has been used as a general predictor of methane emissions. With the need to reduce methane flux uncertainties from tidal wetlands, eddy covariance (EC) techniques provide an integrated methane budget. The goals of this study were to: 1) establish methane emissions… Continue reading Ecosystem Level Methane Fluxes from Tidal Freshwater and Brackish Marshes of the Mississippi River Delta: Implications for Coastal Wetland Carbon Projects
Comparing the Effects of Sertraline with Duloxetine for Depression Severity and Symptoms: A Double-Blind, Randomized Controlled Trial
Abstract Background and Objective Selecting the most effective treatment for major depressive disorder (MDD) is a challenge for clinicians. The aim of this study was to compare the effects of sertraline with duloxetine on major depression signs and symptoms. Methods The trial was a 6-week, randomized, controlled, double-blind study. Sixty-three patients with diagnosis of MDD… Continue reading Comparing the Effects of Sertraline with Duloxetine for Depression Severity and Symptoms: A Double-Blind, Randomized Controlled Trial
Long-lived antitumor T cells from pluripotent stem cells
Current approaches to adoptive T cell therapy are limited by the difficulty of obtaining sufficient numbers of T cells against targeted antigens with useful in vivo characteristics. Theoretically, this limitation could be overcome by using induced pluripotent stem cells (iPSC) that could provide an unlimited source of autologous T cells. However, the therapeutic efficacy of… Continue reading Long-lived antitumor T cells from pluripotent stem cells
Label-Free Neurosurgical Pathology with SRS imaging
The goal of brain tumor surgery is to maximize tumor removal without injuring critical brain structures. Achieving this goal is challenging since it can be difficult to distinguish tumor from non-tumor tissue. While standard histopathology provides information that could assist tumor delineation, it cannot be performed iteratively during surgery as freezing, sectioning, and staining of… Continue reading Label-Free Neurosurgical Pathology with SRS imaging
Antitumor effect of a Golgi disruptor in MET-addicted cancer
The Golgi apparatus is responsible for transporting, processing and sorting numerous proteins in the cell including cell surface-expressed receptor tyrosine kinases (RTK). The small molecule comopund M-COPA (2-methylcoprophilinamide [AMF-26]) disrupts the Golgi apparatus by inhibiting the activation of Arf1, resulting in suppression of tumor growth. Here we report an evaluation of M-COPA activity against RTK-addicted… Continue reading Antitumor effect of a Golgi disruptor in MET-addicted cancer
Improving distress in dialysis (iDiD): a feasibility two-arm parallel randomised controlled trial of an online cognitive behavioural therapy intervention with and without therapist-led telephone support for psychological distress in patients undergoing haemodialysis
Introduction Psychological distress is common in end-stage kidney disease (ESKD) and is associated with poorer health outcomes. Cognitive behavioural therapy (CBT) is recommended in UK clinical guidelines for the management of depression in people with long-term conditions. Access to skilled therapists competent in managing the competing mental and physical health demands of ESKD is limited.… Continue reading Improving distress in dialysis (iDiD): a feasibility two-arm parallel randomised controlled trial of an online cognitive behavioural therapy intervention with and without thera... περισσότερα »
Opportunistic screening of atrial fibrillation by automatic blood pressure measurement in the community
Objective Timely detection of atrial fibrillation (AF) may effectively prevent cardiovascular consequences. However, traditional diagnostic tools are either poorly reliable (pulse palpation) or not readily accessible (ECG) in general practice. We tested whether an automatic oscillometric blood pressure (BP) monitor embedded with an algorithm for AF detection might be effective for opportunistic screening of asymptomatic… Continue reading Opportunistic screening of atrial fibrillation by automatic blood pressure measurement in the community
Combined early and adult life risk factor associations for mid-life obesity in a prospective birth cohort: assessing potential public health impact
Objective The combined effect of life-course influences on obesity development and thus their potential public health impact is unclear. We evaluated combined associations and predicted probabilities for early and adult life risk factors with central and general obesity in mid-adulthood. Setting 1958 British birth cohort. Participants 4629 males and 4670 females with data on waist… Continue reading Combined early and adult life risk factor associations for mid-life obesity in a prospective birth cohort: assessing potential public health impact
Clinical experience of surgically treating giant neurofibromatosis-1
Clinical experience of surgically treating giant neurofibromatosis-1: Abstract The surgical treatment for giant neurofibromatosis-1 (NF-1) requires comprehensive measures. Presently, there is no systematic description of surgical treatment. Because of its high level of risk, we want to share our clinical experience. From 2011 to 2014, patients (*n* = 8, 5 female and 3 male patients, aging from 31 to 45 years-old) were included in the study. The tumours were located on the trunk (*n* = 5) or face (*n* = 3). In addition to routine examination, blood storage was also prepared. Preoper... περισσότερα »
Fox-Fordyce disease (FFD) : Surgical excision and 1550-nm fractionated erbium glass laser
Successful treatment of areolar Fox-Fordyce disease with surgical excision and 1550-nm fractionated erbium glass laser by Hyun H Han, Jun Y Lee, Jong W Rhie via International Wound Journal Abstract Fox-Fordyce disease (FFD) is a rare chronic disorder characterised by persistent inflammation because of the obstruction of apocrine sweat glands, which is a key factor of pathogenesis. The treatment of FFD is known to be difficult, and the modalities of treatment have not yet been widely studied. We report the successful treatment of a case of bilateral areolar FFD by a combination of surg... περισσότερα »
Identification of Comorbidity Risk Factors for Otitis Media in Children Using a 2-Step Multivariate Analysis of Data From Symptom/Sign Histories
Identification of Comorbidity Risk Factors for Otitis Media in 3-Year Old Children Using a 2-Step Multivariate Analysis of Data From Symptom/Sign Histories via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 11 April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Margaretha L. Casselbrant, Ellen M. Mandel, William J. Doyle ObjectivesDetermine if a 2-Step multivariate analysis of historical symptom/sign data for comorbid diseases can abstract high-level constructs useful in assigning a child's “risk” for different... περισσότερα »
Low dose Multisclice-CT (MS-CT)
Examination using modern low dose Multisclice-CT (MS-CT) in Otorhinolaryngology in a six-week-old baby via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 11 April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Sokiranski R. Heidelberg, Plinkert M. Heidelberg, Yildiz F. Istanbul, Pirsig W. Ulm A 6-week-old girl suffered from a growing and recurrently bleeding mass of unrecognizable origin, obstructing the left nose. Using low-dose Multislice-CT the exact diagnostic localization could be found within one minute i... περισσότερα »
Cognitive functions in preschool children with specific language impairment
Cognitive functions in preschool children with specific language impairment via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 11 April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Katrin Reichenbach, Laura Bastian, Saskia Rohrbach, Manfred Gross, Lea Sarrar ObjectiveA growing body of research has focused on executive functions in children with specific language impairment (SLI). However, results show limited convergence, particularly in preschool age. The current neuropsychological study compared performance ... περισσότερα »
Epidemiology of Otitis Media in Children
from Developing Countries: A Systematic Review via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 11 April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Rodrigo DeAntonio, Juan-Pablo Yarzabal, James Philip Cruz, Johannes E. Schmidt, Jos Kleijnen ObjectiveThis systematic review examined the epidemiology of otitis media (OM) in children less of 6 years within 90 developing and newly industrialised countries.MethodsLiterature searches (1992-2011), based on MEDLINE, EMBASE, WHO, Index Medicus, country-specific web... περισσότερα »
Recurrent Thyroglossal duct cyst (TGDC) : Doxycycline
Doxycycline a sclerosant agent to treat a case of recurrent thyroglossal duct cyst via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 12 April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Farid F Ibrahim, Sam J Daniel Thyroglossal duct cyst (TGDC) is one of the most common congenital anterior midline neck masses in children. Sistrunk operation is considered as the cornerstone in TGDC removal. Nevertheless, 5 to 7 % of patients have been reported to show a recurrence even after adequate resection. This necessi... περισσότερα »
SNAP test for children with hypernasality
Evaluating the diagnostic accuracy of Arabic via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 11 April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Tamer Abou-Elsaad, Omayma Afsah, Hemmat Baz, Alzahraa Mansy Nasometry is a method of measuring the acoustic correlates of resonance through a computer-based instrument called nasometer. High nasalance scores in comparison to normative data suggest hypernasality and/or other nasality disorders, while low scores suggest hyponasality. Normative values of nasalance ...περισσότερα »
Efficacy and Safety of FORRAD® for the Management of Radiation-induced Mucositis in Patients With Nasopharyngeal Carcinoma Receiving IMRT
Efficacy and Safety of FORRAD® for the Management of Radiation-induced Mucositis in Patients With Nasopharyngeal Carcinoma Receiving IMRT: *Conditions*: Nasopharyngeal Neoplasms; Stomatitis *Interventions*: Drug: Oral Ulcer Gargle (FORRAD®); Drug: Quadruple mixture, composed of dexamethasone, gentamicin, vitamin B12, and procaine *Sponsor*: Yun-fei Xia Radiation therapy remains the principal treatment for nasopharyngeal carcinoma (NPC). The most frequently occurred radiation-related side effect is probably the radiation-induced oral mucositis (OM), which affects up to ...περισσότερα »
Venous Sinus Stenting To Treat Intractable Pulsatile Tinnitus Caused By Venous Sinus Stenosis
Venous Sinus Stenting To Treat Intractable Pulsatile Tinnitus Caused By Venous Sinus Stenosis: There have been few published studies that examine the efficacy and safety of endovascular treatments on patients with pulsatile tinnitus with venous stenosis. Despite the limited experience with venous sinus stenting to treat pulsatile tinnitus, preliminary results show that venous sinus stenting could represent a viable alternative for refractory pulsatile tinnitus patients with venous sinus stenosis. The purpose of our study is to evaluate the safety and efficacy of this procedure i... περισσότερα »
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IV Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IV Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery: This phase II trial studies how well radiation therapy with or without cisplatin works in treating patients with stage III-IV squamous cell carcinoma of the head and neck who have undergone surgery. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping th... περισσότερα »
Keratin 14 Expression in Epithelial Progenitor Cells of the Developing Human Cornea
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/1YsLoWj via IFTTT
Ist Radio(chemo)therapie wirklich der zukünftige Standard für die Behandlung von Oropharynxkarzinomen?
Ist Radio(chemo)therapie wirklich der zukünftige Standard für die Behandlung von Oropharynxkarzinomen? Zusammenfassung Die Behandlung von Patienten mit einem Plattenepithelkarzinom des Oropharynx (OPSCC) erfordert eine interdisziplinäre Zusammenarbeit. Therapieziel ist neben der Tumorkontrolle der Funktions- und Organerhalt. Hierzu wird die primäre gleichzeitige Radiochemotherapie (RCT) v. a. bei lokal fortgeschrittenen Kopf-Hals-Tumoren eingesetzt. Alternativ erfolgt die sequenzielle RCT, zunächst als Induktionschemotherapie durchgeführt und dann von einer alleinigen Radiatio oder e... περισσότερα »
3D-Visualisierung und Analyse von Stimmlippenschwingungen
3D-Visualisierung und Analyse von Stimmlippenschwingungen ZusammenfassungHintergrund Heutige visuelle Untersuchungsmethoden des Kehlkopfes und der Stimmlippenbewegung erlauben vorwiegend eine zweidimensionale Darstellung der real dreidimensionalen Strukturen und Bewegungen. Die vertikale Bewegungskomponente der Stimmlippen wird meist vernachlässigt, was zu einem Informationsverlust führt. Neuere Studien zeigen, dass die vertikale Komponente in einer ähnlichen Größenordnung wie die laterale Komponente liegt und einen nicht unerheblichen Anteil am Phonationsprozess hat. Ziel der Arbeit ... περισσότερα »
Auswirkungen aktueller Trends in Gesellschaft, Medizin und Politik auf die Zukunft der HNO-Heilkunde
Auswirkungen aktueller Trends in Gesellschaft, Medizin und Politik auf die Zukunft der HNO-Heilkunde ZusammenfassungHintergrund Jedes medizinische Fachgebiet unterliegt einem permanenten Wandel, so auch die HNO-Heilkunde. Anhand der Analyse der Trends gesellschaftlicher Veränderungen, des medizinischen Fortschritts und politscher Konsequenzen wird versucht, die Auswirkungen auf die HNO-Heilkunde partiell zu antizipieren. Trends Der demographische Wandel und medizinische Fortschritt führen zu einem gesteigerten medizinischen Bedarf. Hinzu kommen die sog. Feminisierung der Medizin sowi... περισσότερα »
Ballondilatation der Tuba auditiva bei Mittelohroperationen
Ballondilatation der Tuba auditiva bei Mittelohroperationen ZusammenfassungHintergrund Die Entstehung von Mittelohrerkrankungen wird u. a. auf eine unzureichende Tubenfunktion zurückgeführt. In klinischen Fallserien wurde über die Ergebnisse der Ballondilatation zur Therapie von Tubendysfunktionen berichtet. Ziel Es soll untersucht werden, ob Patienten mit geplanter Operation aufgrund einer chronischen Mittelohrerkrankung von einer zusätzlichen Ballondilatation der Tuba auditiva profitieren. Methoden In eine randomisierte, kontrollierte, für Patienten und Untersucher verblindete Studi...περισσότερα »
HNSCC : Adenosine-mediated immunosuppression
Adenosine-mediated immunosuppression in patients with squamous cell carcinoma of the head and neck Abstract This review article describes the potential role of ectonucleotidase activity, adenosine metabolism, and the adenosinergic signaling pathway in the suppression of the host immune system in patients with head and neck cancer. Identifying such mechanisms leads to a better understanding of immunosuppressive mechanisms in this patient population. Further, potential targets for immunotherapy in an adjuvant approach to treating squamous cell carcinoma of the head and neck in the futu... περισσότερα »
Rehabilitation bei Fazialisparese und Schwindel bei Patienten mit Vestibularisschwannom
Rehabilitation bei Fazialisparese und Schwindel bei Patienten mit Vestibularisschwannom: Zusammenfassung HintergrundFazialisparese und Schwindel als Symptom eines Vestibularisschwannoms (VS) oder als Folge der Therapie beeinträchtigen die Lebensqualität der Patienten erheblich. FragestellungDie Arbeit analysierte die aktuelle Literatur zum Thema und gibt darauf basierend Handlungsempfehlungen. Material und MethodeEs handelt sich um eine PubMed-basierte Literaturrecherche der letzten 10 Jahre. ErgebnisseZur Behandlung der akuten postoperativen Fazialisparese nach VS-Oper... περισσότερα »
HNO
Rehabilitation bei Fazialisparese und Schwindel bei Patienten mit Vestibularisschwannom ZusammenfassungHintergrund Fazialisparese und Schwindel als Symptom eines Vestibularisschwannoms (VS) oder als Folge der Therapie beeinträchtigen die Lebensqualität der Patienten erheblich. Fragestellung Die Arbeit analysierte die aktuelle Literatur zum Thema und gibt darauf basierend Handlungsempfehlungen. Material und Methode Es handelt sich um eine PubMed-basierte Literaturrecherche der letzten 10 Jahre. Ergebnisse Zur Behandlung der akuten postoperativen Fazialisparese nach VS-Operation gibt e... περισσότερα »
Advice about Work-Related Issues to Peers and Employers from Head and Neck Cancer Survivors
Advice about Work-Related Issues to Peers and Employers from Head and Neck Cancer Survivors: by Carolyn S. Dewa, Lucy Trojanowski, Sietske J. Tamminga, Jolie Ringash, Maurene McQuestion, Jeffrey S. Hoch Purpose The purpose of this exploratory and descriptive study is to contribute to the sparse return-to-work literature on head and neck cancer (HNC) survivors. Interview participants were asked to reflect upon their work-related experience with cancer by answering two specific questions: (1) What advice would you give someone who has been newly diagnosed with head and neck cancer...περισσότερα »
Why errors happen during lifesaving EMS interventions
Why errors happen during lifesaving EMS interventions: By Bradley Dean Following the release of two pivotal landmark reports by the Institute of Medicine Committee on Quality of Health Care in America in 1999 and 2001, patient safety has become a priority issue and area of focus, but only recently has EMS joined the movement [1,2]. While some demonstrated improvement has occurred, there is still much room for improvement in delivering safe, high-quality health care within the realm of EMS. In late 2015 another report, "Free from Harm: Accelerating Patient Safety Improvement Fiftee... περισσότερα »
•HNC margins status determination methods are not well defined in prior reports. •20% of margins from head and neck cancer resections can’t be determined with chart review. •Improvement in methods for surgical margin documentation are needed. •Inability to define margins on audit hampers research.
Third party assessment of resection margin status in head and neck cancer: [image: gr1.sml] Current NCCN Clinical Practice Guidelines in Oncology for Head and Neck Cancers includes positive margins as an adverse feature for all treatment sites [1]. There remains a lack of consensus on what defines an adequate oncological surgical resection margin. The most widely accepted definition was proposed by Looser et al. [2], defining positive margins as any specimen with tumor at or within 5mm of the cut edge, or any specimen with premalignant change or in-situ cancer in at the cut edge...περισσότερα »
Laryngo-Rhino-Otologie
Kommentar der Schriftleitung Nasenpolypen – Prednisolon reduziert perioperativen Blutverlust Peritonsillarabszess – Nadelaspiration ist effektive Erstlinientherapie Chirurgische Zugangswege in der Ohrchirurgie Injektion von Bauchfett bei radiogenen Wundheilungsstörungen Wundheilungsstörungen in bestrahlten Arealen der Kopf-Hals-Region stellen eine relevante Herausforderung im klinischen Alltag dar. Insbesondere pharyngokutane Fisteln können die Morbidität dieses Patientengutes erhöhen. Die Injektion von Lipoaspiraten bei radiogenen Wundheilungsstörungen wird in der Literatur vielve...περισσότερα »
Tumor Volume Predicts Survival Rate of Advanced Nasopharyngeal Carcinoma Treated with Concurrent Chemoradiotherapy
Tumor Volume Predicts Survival Rate of Advanced Nasopharyngeal Carcinoma Treated with Concurrent Chemoradiotherapy: Objective To delineate the prognostic value of primary gross tumor volume (GTVp) for patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated with concurrent chemoradiotherapy. Study Design Analysis of prognostic variables in a prospective cohort. Setting Department of Radiotherapy, First Affiliated Hospital of Guangxi Medical University, China. Subjects and Methods Between January 2006 and August 2008, 249 patients with stage III-IVb NPC, all t... περισσότερα »
Aspirin-exacerbated respiratory disease (AERD) represents a severe form of chronic rhinosinusitis (CRS) characterized by nasal polyposis, bronchial asthma, and aspirin intolerance
The Role of Surgery in Management of Samters Triad: A Systematic Review: Objective Aspirin-exacerbated respiratory disease (AERD) represents a severe form of chronic rhinosinusitis (CRS) characterized by nasal polyposis, bronchial asthma, and aspirin intolerance. This syndrome, known as Samter’s triad, is more difficult to manage than routine CRS and poses a challenge to the treating clinician. We performed a systematic review of the literature to determine the role of endoscopic sinus surgery in patients with AERD who are on adjuvant medical therapies. Data Sources PubMed, Embase...περισσότερα »
Predictors of Foreign Body Aspiration in Children
Predictors of Foreign Body Aspiration in Children: Objectives To examine the sensitivity and specificity of history, physical examination, and radiologic studies as predictors of foreign body aspiration in children. Study Design Case series with chart review. Setting Tertiary care children’s hospital. Subjects and Methods Medical records were reviewed for 102 children who presented to our institution from 2006 to 2013 with suspected foreign body aspiration and who underwent endoscopy. Data included symptoms, physical examination, radiologic, and endoscopy findings. Descriptive s... περισσότερα »
Neural control of visual search by frontal eye field: chronometry of neural events and race model processes
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 31 δευτερόλεπτα
We investigated the chronometry of neural processes in frontal eye fields of macaques performing double-step saccade visual search in which a conspicuous target changes location in the array on a random fraction of trials. Durations of computational processes producing a saccade to original and final target locations (GO1 and GO2, respectively) are derived from response times (RT) on different types of trials. In these data, GO2 tended to be faster than GO1, demonstrating that inhibition of the initial saccade did not delay production of the compensated saccade. Here, we measured ... περισσότερα »
Cephalic Vein Transposition in the Vessel-Depleted Neck
*Cephalic Vein Transposition in the Vessel-Depleted Neck* *[HTML] από jamanetwork.com* [HTML] The thoracoacromial/*cephalic *vascular system for microvascular anastomoses in the*vessel*-*depleted neck* *JR Harris, E Lueg, E Genden… - … –Head & Neck Surgery, 2002 - archotol.jamanetwork.com* *Research from JAMA Otolaryngology–Head & Neck Surgery — The Thoracoacromial/CephalicVascular System for Microvascular Anastomoses in the Vessel-Depleted Neck.* *Γίνεται αναφορά σε 38 Σχετικά άρθρα Όλες οι 7 εκδοχές Παράθεση Αποθήκευση* *[PDF] από researchgate.net* *Vessel*‐*depleted neck*: Tech... περισσότερα »
Ischemic Colitis as a Complication of Medication Use
An Analysis of the Federal Adverse Event Reporting System: Abstract BackgroundMore than one decade ago, rising cases of ischemic colitis (IC) prompted the Federal Drug Administration to revoke alosetron’s approval as treatment of irritable bowel syndrome (IBS). The aim of this study was to identify medical therapies associated with development of IC. MethodsThe Federal Adverse Event Reporting System was queried for the time between January 2004 and September 2015. We identified reports listing IC as treatment complication and extracted suspected causative and concomitantly adm...περισσότερα »
Rotational speed invariant fault diagnosis in bearings using vibration signal imaging and local binary patterns
Rotational speed invariant fault diagnosis in bearings using vibration signal imaging and local binary patterns: Structural vibrations of bearing housings are used for diagnosing fault conditions in bearings, primarily by searching for characteristicfault frequencies in the envelope power spectrum of the vibration signal. The fault frequencies depend on the non-stationary angular speed of the rotating shaft. This paper explores an imaging-based approach to achieve rotational speed independence. Cycle length segments of the rectified vibration signal are stacked to construct gra... περισσότερα »
Gait speed on the stability of walking
The influence of gait speed on the stability of walking among the elderly via Gait & Posture Publication date: Available online 12 April 2016 *Source:*Gait & Posture Author(s): Yifang Fan, Zhiyu Li, Shuyan Han, Changsheng Lv, Bo Zhang Walking speed is a basic factor to consider when walking exercises are prescribed as part of a training programme. Although associations between walking speed, step length and falling risk have been identified, the relationship between spontaneous walking pattern and falling risk remains unclear. The present study, therefore, examined the stability of spo...περισσότερα »
Pooled, but not single-neuron, responses in macaque V4 represent a solution to the stereo correspondence problem
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 35 δευτερόλεπτα
Binocular disparity is an important cue for depth perception. To correctly represent disparity, neurons must find corresponding visual features between the left- and right-eye images. The visual pathway ascending from V1 to inferior temporal cortex solves the correspondence problem. An intermediate area, V4, has been proposed to be a critical stage in the correspondence process. However, the distinction between V1 and V4 is unclear, because accumulating evidence suggests that the process begins within V1. In this article, we report that the pooled responses in macaque V4, but not ...περισσότερα »
Perceiving and acting upon weight illusions in the absence of somatosensory information
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 35 δευτερόλεπτα
When lifting novel objects, individuals' fingertip forces are influenced by a variety of cues such as volume and apparent material. This means that heavy-looking objects tend to be lifted with more force than lighter-looking objects, even when they weigh the same amount as one another. Expectations about object weight based on visual appearance also influence how heavy an object feels when it is lifted. For instance, in the "size-weight illusion," small objects feel heavier than equally weighted large objects. Similarly, in the "material-weight illusion," objects that seem to be m... περισσότερα »
A quantitative confidence signal detection model: 1. Fitting psychometric functions
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 35 δευτερόλεπτα
Perceptual thresholds are commonly assayed in the laboratory and clinic. When precision and accuracy are required, thresholds are quantified by fitting a psychometric function to forced-choice data. The primary shortcoming of this approach is that it typically requires 100 trials or more to yield accurate (i.e., small bias) and precise (i.e., small variance) psychometric parameter estimates. We show that confidence probability judgments combined with a model of confidence can yield psychometric parameter estimates that are markedly more precise and/or markedly more efficient than ...περισσότερα »
Secondary School Teachers' Beliefs, Attitudes, and Reactions to Stuttering
Secondary School Teachers' Beliefs, Attitudes, and Reactions to Stuttering: Purpose The study identifies teachers' beliefs about and attitudes toward stuttering and explores to what extent these beliefs and attitudes prompt specific teachers' reactions to the stuttering of a student. Method Participants were teachers in secondary education in Flanders (Belgium), currently teaching an adolescent who stutters. They were the student's class teacher or instructed a course in which communication is important. Ten semistructured interviews were conducted and analyzed thematically. Resu...περισσότερα »
Biomarkers for squamous dysplasia and carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Background: The 5-year survival rate of esophageal cancer is less than 10% in developing countries, where more than 90% of these cancers are squamous cell carcinomas (ESCC). Endoscopic screening is undertaken in high incidence areas. Biomarker analysis could reduce the subjectivity associated with histological assessment of dysplasia and thus improve diagnostic accuracy. The aims of this study were therefore to identify biomarkers for esophageal squamous dysplasia and carcinoma. Methods: A publically available dataset was used to identify genes with differential expression in ESCC...περισσότερα »
POLG-Associated Ataxia Presenting as a Fragile X Tremor/Ataxia Phenocopy Syndrome
Abstract Hyperintensities in the middle cerebellar peduncles (MCP), known as the MCP sign, and progressive late-onset ataxia constitute major characteristics of the fragile X tremor/ataxia syndrome (FXTAS). Here, we describe a 60-year-old male affected by ataxia due to biallelic mutations in the mitochondrial polymerase gamma (POLG) gene in which hyperintensities of the middle cerebellar peduncles… Continue reading POLG-Associated Ataxia Presenting as a Fragile X Tremor/Ataxia Phenocopy Syndrome
Vitamin D
Vitamin D: A steroid vitamin which promotes the intestinal absorption and metabolism of calcium and phosphorus. Under normal conditions of sunlight exposure, no dietary supplementation is necessary because sunlight promotes adequate vitamin D synthesis in the skin. Deficiency can lead to bone deformity (rickets) in children and bone weakness (osteomalacia) in adults. Vitamin D comes… Continue reading Vitamin D
The Journal of Transport History
The Journal of Transport History, published by SAGE Publications, last updated on 2016-04-12, available at http://jth.sagepub.com from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://jth.sagepub.com/ via IFTTT
Biomarkers for squamous dysplasia and carcinoma
Background: The 5-year survival rate of esophageal cancer is less than 10% in developing countries, where more than 90% of these cancers are squamous cell carcinomas (ESCC). Endoscopic screening is undertaken in high incidence areas. Biomarker analysis could reduce the subjectivity associated with histological assessment of dysplasia and thus improve diagnostic accuracy. The aims of… Continue reading Biomarkers for squamous dysplasia and carcinoma
‘P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model’
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Issue Information – Journal Information
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Issue Information – TOC
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Polymorphisms of extrinsic death receptor apoptotic genes (FAS −670 G>A, FASL −844 T>C) in coronary artery disease
Abstract Apoptosis plays an important role in atherogenesis and rupture of vulnerable plaques in coronary artery disease. FAS and FAS ligand (FASL) induce apoptosis when FAS binds to FAS-L. However sFas blocks apoptosis by binding to FAS and FASL or sFasL. The present study is sought to examine the role of extrinsic apoptotic genes (FAS,… Continue reading Polymorphisms of extrinsic death receptor apoptotic genes (FAS −670 G>A, FASL −844 T>C) in coronary artery disease
Suppression of c-Myc induces apoptosis via an AMPK/mTOR-dependent pathway by 4- O -methyl-ascochlorin in leukemia cells
Abstract 4-O-Methyl-ascochlorin (MAC) is a methylated derivative of the prenyl-phenol antibiotic ascochlorin, which was isolated from an incomplete fungus, Ascochyta viciae. Although the effects of MAC on apoptosis have been reported, the underlying mechanisms remain unknown. Here, we show that MAC promoted apoptotic cell death and downregulated c-Myc expression in K562 human leukemia cells. The… Continue reading Suppression of c-Myc induces apoptosis via an AMPK/mTOR-dependent pathway by 4- O -methyl-ascochlorin in leukemia cells
Combinatorial treatment with anacardic acid followed by TRAIL augments induction of apoptosis in TRAIL resistant cancer cells by the regulation of p53, MAPK and NFκβ pathways
Abstract TRAIL, an apoptosis inducing cytokine currently in phase II clinical trial, was investigated for its capability to induce apoptosis in six different human tumor cell lines out of which three cell lines showed resistance to TRAIL induced apoptosis. To investigate whether Anacardic acid (A1) an active component of Anacardium occidentale can sensitize the resistant… Continue reading Combinatorial treatment with anacardic acid followed by TRAIL augments induction of apoptosis in TRAIL resistant cancer cells by the regulation of p53, MAPK and NFκβ pathways
A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 55 δευτερόλεπτα
Abstract It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally […]
A prospective microstructure imaging study in mixed-martial artists using geometric measures and diffusion tensor imaging: methods and findings
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 55 δευτερόλεπτα
Abstract Although diffusion magnetic resonance imaging (dMRI) has been widely used to characterize the effects of repetitive mild traumatic brain injury (rmTBI), to date no studies have investigated how novel geometric models of microstructure relate to more typical diffusion tensor imaging (DTI) sequences. Moreover, few studies have evaluated the sensitivity of different registration pipelines (non-linear, […]
Active pain coping is associated with the response in real-time fMRI neurofeedback during pain
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 55 δευτερόλεπτα
Abstract Real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback is used as a tool to gain voluntary control of activity in various brain regions. Little emphasis has been put on the influence of cognitive and personality traits on neurofeedback efficacy and baseline activity. Here, we assessed the effect of individual pain coping on rt-fMRI neurofeedback during […]
Beloved owner gone, but oldest gay bar still a welcoming haven – Milwaukee Journal Sentinel
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 55 δευτερόλεπτα
Milwaukee Journal Sentinel Beloved owner gone, but oldest gay bar still a welcoming haven Milwaukee Journal Sentinel Joe, who lived in Franklin and had survived four kinds of cancer, was diagnosed last August with ALS, or Lou Gehrig’s disease. It took him quickly. … Rebecca was amused by the bar’s list of tongue-in-cheek house rules, […]
Type 2 diabetes and risk of low-energy fractures in postmenopausal women: meta-analysis of observational studies
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 55 δευτερόλεπτα
Abstract Background Observational studies on osteoporotic fractures in patients with type 2 diabetes indicate their increased incidence compared to those without diabetes, but results are inconsistent. Currently, type 2 diabetes is not considered as an independent risk factor for low-energy fractures in elder subjects. The aim of the study was to assess the association between […]
Health insurance coverage, care accessibility and affordability for adult survivors of childhood cancer: a cross-sectional study of a nationally representative database
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 55 δευτερόλεπτα
Abstract Purpose We describe national patterns of health insurance coverage and care accessibility and affordability in a national sample of adult childhood cancer survivors (CCS) compared to adults without cancer. Methods Using data from the 2010–2014 National Health Interview Survey (NHIS), we selected a sample of all CCS age 21 to 65 years old and […]
Publishing anaesthetists’ clinical outcomes
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 55 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Nnz3gf via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Unreported paediatric awareness during surgery
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 55 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1N7CkFv via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Radical-7 pulse CO-oximetry
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 55 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Nnz57T via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Time to abandon fibreoptic intubation? Not yet
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 55 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1N7Ckp8 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Outcome of a cohort of severe cerebral venous thrombosis in intensive care
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Severity of cerebral venous thrombosis (CVT) may require the transfer to intensive care unit (ICU). This report described the context for CVT transfer to ICU, the strategy of care and the outcome after 1 year. from Emergencies via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Wq6p5l via IFTTT
p53 expression but not p16 INK4A correlates with human papillomavirus-associated esophageal squamous cell carcinoma in Kazakh population
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: sfx_links?getImage] Background: p16 INK4A expression has been used as a surrogate marker for human papillomavirus (HPV) infection in cervical cancer and head and neck cancer. p53 has also been reported as a feasible marker to identify HPV-positive oropharyngeal carcinoma and penile lesions. This study aimed to investigate p16 INK4A and p53 expression levels and their correlation with HPV status and clinical parameters in Kazakh patients with esophageal squamous cell carcinoma. Methods: Immunohistochemical expression of p16 INK4A and p53 were evaluated in 163 cases of esopha... περισσότερα »
Correlated gene expression encoding serotonin (5-HT) receptor 4 and 5-HT transporter in proximal colonic segments of mice across different colonization states and sexes
Abstract The production and handling of serotonin (5-HT) is an important determinant of colonic motility and has been reported to be altered in gastrointestinal (GI) disorders such as irritable bowel syndrome (IBS). Recent studies suggest that the intestinal microbiota and sex of the host can influence expression of genes involved in 5-HT biosynthesis and signaling. While expression of genes in serotonergic pathways has been shown to be variable, it remains unclear whether genes within this pathway are coregulated. As a first step in that direction, we investigated potential correl... περισσότερα »
Impact of electrical stimulation of the stomach on gastric distension-induced emesis in the musk shrew
Abstract Background Gastric electrical stimulation (GES) is implicated as a potential therapy for difficult-to-treat nausea and vomiting; however, there is a lack of insight into the mechanisms responsible for these effects. This study tested the relationship between acute GES and emesis in musk shrews, an established emetic model system. Methods Urethane-anesthetized shrews were used to record emetic responses (monitoring intra-tracheal pressure and esophageal contractions), respiration rate, heart rate variability, blood pressure, and gastrointestinal electromyograms. We inves...περισσότερα »
Clinical outcomes after spontaneous and nucleos(t)ide analogue-treated HBsAg seroclearance in chronic HBV infection
Summary Background Both spontaneous and nucleos(t)ide analogue (Nuc)-treated hepatitis B surface antigen (HBsAg) seroclearance are associated with excellent clinical outcomes. Aim To conduct a case–control study to explore whether there is difference of clinical outcomes between these two groups. Methods A total of 312 chronic hepatitis B patients with spontaneous HBsAg seroclearance and 110 patients with Nuc-treated HBsAg seroclearance were recruited retrospectively. Propensity score (PS) matching method produced 98 patients in each group for comparison. The development of hep...περισσότερα »
Editorial: alginates for inadequate response to a proton pump inhibitor in gastro-oesophageal reflux disease
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Editorial: alginates for inadequate response to a proton pump inhibitor in gastro-oesophageal reflux disease – authors’ reply
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Anaesthetist contribution to mortality after cardiac surgery – a reply
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Rectus sheath catheter entrapment
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Better names for Never Events – a reply
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Publishing anaesthetists’ clinical outcomes
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Unreported paediatric awareness during surgery
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Molecular Modeling and Physicochemical Properties of Supramolecular Complexes of Limonene with α- and β-Cyclodextrins
Abstract This study evaluated three different methods for the formation of an inclusion complex between alpha- and beta-cyclodextrin (α- and β-CD) and limonene (LIM) with the goal of improving the physicochemical properties of limonene. The study samples were prepared through physical mixing (PM), paste complexation (PC), and slurry complexation (SC) methods in the molar ratio… Continue reading Molecular Modeling and Physicochemical Properties of Supramolecular Complexes of Limonene with α- and β-Cyclodextrins
BIG READ: Meet the boy who beat cancer against all the odds – Fraser Coast Chronicle
BIG READ: Meet the boy who beat cancer against all the odds Fraser Coast Chronicle Known as an angiosarcoma, the growth was wrapping its invasive tendrils around the honeycomb structure of Sam’s temporal bone near his ear. Like something from a B-grade horror film, the cancer knitted its vile tendrils around the vital structures that… Continue reading BIG READ: Meet the boy who beat cancer against all the odds – Fraser Coast Chronicle
Bone Resection Versus Setback in Reduction Malarplasty: A Quantitative Analysis of the Migration of the Summit of the Zygoma
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Background We hypothesized that the amount of bone resection and setback together controls the effect of reducing the zygomatic body during reduction malarplasty; however, quantitative analyses of this movement are lacking. Methods A retrospective study of patients who underwent reduction malarplasty between Aug. 2013 and Jan. 2015 was performed. We used 3-dimensional computed tomography […]
Potential Safety Loophole of Fat Grafting in Breast Cancer Patients
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Autologous fat grafting (AFG) accounts for 9.1 % of all cosmetic surgical procedures in the world. Its use has been increasing tremendously in breast reconstruction and produces satisfying outcomes. However, the lack of standard guidelines for routine screening protocols in breast cancer patients before and after AFG warrants consideration of the safety of AFG […]
Editorial
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Peripheral facial palsy: muscle activity in different onset times
RESUMO Objetivo : Avaliar, por meio da eletromiografia de superfície (EMGs), a atividade dos músculos risório e zigomático, durante a produção do sorriso voluntário, comparando os dados em dois grupos de indivíduos com tempos diferentes de início da paralisia facial periférica (PFP). Métodos : 140 adultos distribuídos em três grupos: G1 (35 indivíduos com início da PFP entre 0 e 3 meses); G2 (35 indivíduos com início da PFP entre 3 e 6 meses); GC (70 controles saudáveis). Todos os participantes foram submetidos à avaliação que consistiu na aplicação de uma escala clínica para avalia... περισσότερα »
Multimedia material about velopharynx and primary palatoplasty for orientation of caregivers of children with cleft lip and palate
RESUMO Objetivo: O objetivo deste trabalho é apresentar e discutir a elaboração e a avaliação de material multimídia, destinado à orientação dos cuidadores de bebês com fissura labiopalatina, mais especificamente orientação sobre a velofaringe, palatoplastia primária e fala com relação às fissuras labiopalatinas. Métodos: A elaboração do material envolveu interdisciplinarmente as áreas de Fonoaudiologia, Odontologia e Arte. Permeados por princípios da arte-educação, houve definição e execução dos seguintes aspectos: caracterização do público alvo, caracterização do conteúdo, identif...περισσότερα »
Signs and symptoms of temporomandibular disorders in women and men
RESUMO Introdução: Mulheres são mais susceptíveis às desordens temporomandibulares (DTM), contudo, estudos que tenham comparado os gêneros em amostras brasileiras são raros. Objetivo: Analisar a proporção de homens e mulheres, bem como a associação entre o gênero e as variáveis idade, duração do problema e sintomas de DTM em pacientes admitidos para tratamento em uma clínica universitária. Métodos: Foram coletados e analisados dados de entrevista e avaliação de mil protocolos de pacientes com diagnóstico de DTM, divididos em 2 grupos, masculino (n=177) e feminino (n=823). Foi realiz... περισσότερα »
Speech perception in users of hearing aid with auditory neuropathy spectrum disorder
RESUMO Objetivo: Analisar a percepção de fala em crianças portadoras de deficiência auditiva pré-lingual com desordem do espectro da neuropatia auditiva (DENA) usuárias de aparelho de amplificação sonora individual (AASI) bilateral. Métodos: Trata-se de um estudo descritivo e exploratório realizado no Centro de Pesquisas Audiológicas da Sessão de Implante Coclear do Hospital de Reabilitação de Anomalias Craniofaciais (HRAC/USP). Foram avaliadas 4 crianças com idade variando entre 8 anos e 3 meses e 12 anos e 2 meses. Foram utilizados: listas de palavras monossílabas, dissílabas, pal...περισσότερα »
Auditory training program in subjects with tinnitus
RESUMO O zumbido pode ser definido como a percepção consciente de um som, sem a presença de estimulação acústica externa. Considerando o prejuízo causado pelo zumbido e a falta de tratamentos definitivos, fica evidente a necessidade de alternativas para reabilitação de pessoas com zumbido. A hipótese é que o treinamento auditivo pode causar uma reorganização plástica desse sistema, promovendo uma melhora do sintoma. Objetivo: Verificar o efeito de um programa de treinamento auditivo em portadores de zumbido na percepção desse sintoma. Métodos: Participaram 12 indivíduos portadores d... περισσότερα »
Ocular and cervical vestibular evoked myogenic potential simultaneous in normal individuals
RESUMO Objetivo: Caracterizar o registro e analisar os resultados do potencial evocado miogênico vestibular cervical e ocular combinado em indivíduos sem queixas auditivas e vestibulares. Métodos: Participaram da pesquisa 30 indivíduos sem queixa auditiva e com audição dentro dos padrões de normalidade. A coleta de dados foi realizada por meio do potencial evocado miogênico vestibular cervical e ocular registrados simultaneamente. Resultados: Houve diferença entre as orelhas direita e esquerda para a amplitude das ondas P13 e N23 do potencial evocado miogênico vestibular cervical e ...περισσότερα »
