Risk factors for surgical site infection
Risk factors for surgical site infection after supraclavicular flap reconstruction in patients undergoing major head and neck surgery: [image: cover.gif?v=1&s=a2a78d1ada9d36b5007beef2] Abstract Background Surgical site infections can adversely affect flaps in head and neck reconstruction. The purpose of this study was to evaluate the risk factors of surgical site infections in supraclavicular artery island flap reconstructions. Methods Records of patients undergoing head and neck surgery from 2011 to 2014 with supraclavicular artery island flap reconstruction at a single specialt...περισσότερα »
Erratum to: An arthroscopic safety zone for the medial compartment of the hip joint
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/2477SQn via IFTTT
Anatomical study of the internal thoracic arteries; implications for use in coronary artery bypass graft surgery
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Abstract Purpose The feasibility of coronary artery bypass grafting using an internal thoracic artery (ITA) depends on the length of the graft with respect to the optimal route to reach the coronary target. The goal of this study was to assess the gain in length afforded by skeletonization and to evaluate the lengths of different pathways of the ITAs to the left coronary arteries. Methods The left and right ITAs were dissected out from 20 specimens and measured before and after skeletonization. Distance between the origin of the right ITA and the base of the left atrial appendage,... περισσότερα »
Extraskeletal myxoid chondrosarcoma of maxilla: A rare entity
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*Janardan B Garde, Sangeeta J Palaskar, Pargatsingh T Kathuriya* Journal of Oral and Maxillofacial Pathology 2016 20(1):151-153 from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1NF4rXJ via IFTTT
Message from IAOMP secretary
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*N Chaitanya Babu* Journal of Oral and Maxillofacial Pathology 2016 20(1):2-2 from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1Sg71sH via IFTTT
Prions in dentistry: A need to be concerned and known
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*B Sushma, Sachin Gugwad, Rajdeep Pavaskar, Shambhvi A Malik* Journal of Oral and Maxillofacial Pathology 2016 20(1):111-114 Prion diseases were first discovered by Stanley B. Prusiner who defined prions as infectious, transmissible proteinaceous particles that lack nucleic acid and are composed exclusively of a modified isoform of the noninfectious cellular prion protein (PrPC). These are incurable neurodegenerative conditions affecting both animals and humans. They may be sporadic, infectious or inherited in origin. Human prion diseases include Creutzfeldt-Jakob desease (CJD), Ger...περισσότερα »
Message from IAOMP treasurer
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*P Nainani* Journal of Oral and Maxillofacial Pathology 2016 20(1):3-3 from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1Sg71sB via IFTTT
Message from IAOMP president
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*K Ranganathan* Journal of Oral and Maxillofacial Pathology 2016 20(1):1-1 from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1NF4rXC via IFTTT
From the Editor's desk
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*Radhika Manoj Bavle* Journal of Oral and Maxillofacial Pathology 2016 20(1):4-4 from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1Sg747I via IFTTT
Precursor B-cell lymphoblastic lymphoma of oral cavity: A case report with its diagnostic workup
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*Komal Ladharam Talreja, Suresh Ramchandra Barpande, Jyoti Dilip Bhavthankar, Mandakini S Mandale* Journal of Oral and Maxillofacial Pathology 2016 20(1):133-136 Lymphoblastic lymphoma (LBL), seen primarily in children or young adults, is a malignant neoplasia that originates from B or T lymphocyte precursors and rarely occurs in the oral cavity. In this localization, neither the clinical features nor the radiologic appearances are pathognomic and can pose significant diagnostic problems. Histopathologically, it presents as a round blue cell tumor. An early and accurate diagnosis of... περισσότερα »
Cancer Conundrum
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*Radhika M Bavle, M Sudhakara* Journal of Oral and Maxillofacial Pathology 2016 20(1):5-8 from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1Sg747C via IFTTT
Unusual presentation of squamous cell carcinoma in young female patient: A case report and review of literature
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*Jasbir Kaur, Anantpreet Singh, Rohit Chopra* Journal of Oral and Maxillofacial Pathology 2016 20(1):163-163 Oral squamous cell carcinoma is the most common "malignant neoplasm" of epithelial origin usually affecting individuals over 50 years of age. It is rare in patients aged <40 years old. This report describes a case of squamous cell carcinoma involving anterior mandibular alveolar region in a 17-year-old female patient, with no history of deleterious habits. This report focuses on etiological factors, diagnosis and prognosis related to the case. from Anatomy Pathology via xlom...περισσότερα »
Toto bodies
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*Kunal Sah* Journal of Oral and Maxillofacial Pathology 2016 20(1):9-10 from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1Sg73Rj via IFTTT
Pyruvic acid levels in serum and saliva: A new course for oral cancer screening?
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*Manohara A Bhat, K.V.V. Prasad, Dheeraj Trivedi, BR Rajeev, Hemanth Battur* Journal of Oral and Maxillofacial Pathology 2016 20(1):102-105 Objective: Cancerous cells show increased glycolysis rate. This will increase overall levels of pyruvate as it is one of the end products of glycolysis. The present on-going study is to estimate the levels of pyruvate in saliva and serum among healthy and oral cancer subjects. Settings and Design: Hospital-based cross-sectional comparative study. Methodology: A total of 50 subjects among healthy and oral cancer subjects were selected based on cl... περισσότερα »
Do the presence of Barr bodies in male jail inmates indicates criminality: A pilot study
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*Mayuri K Kulkarni, Pradeep D Somannavar, Vijayalakshmi Kotrashetti, Ramakant Nayak, Jagadish Hosmani, Deepa Babji* Journal of Oral and Maxillofacial Pathology 2016 20(1):11-15 Background: Cytogenetic studies from past decades have shown that interphase cells of female cats contain a densely stained chromatin mass in their nuclei called as Barr bodies (BBs) named after the scientist Murray Barr. BBs are unique chromatin structures formed due to the condensation of the X-chromosome. Many psychopathic disorders originate from defective genes including the multiple X syndromes. Males w...περισσότερα »
Epigenetics: A possible answer to the undeciphered etiopathogenesis and behavior of oral lesions
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*Narendra Nath Singh, Aakanksha Peer, Sherin Nair, Rupesh K Chaturvedi* Journal of Oral and Maxillofacial Pathology 2016 20(1):122-128 Much controversy has existed over the etiopathogenesis and management of oral lesions, especially oral malignancies. The knowledge of genetic basis is proving to be inadequate in the light of emerging new mechanisms termed epigenetic phenomena. The present review article aims to understand the role of epigenetic mechanisms in oral lesions. Epigenetics is the study of acquired changes in chromatin structure that arise independently of a change in the ...περισσότερα »
Long-term effect of tobacco on unstimulated salivary pH
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*Neeraj Grover, Jyoti Sharma, Shamindra Sengupta, Sanjeet Singh, Nishant Singh, Harjeet Kaur* Journal of Oral and Maxillofacial Pathology 2016 20(1):16-19 Aims and Objectives: The aim of this study was to analyze and compare the effects of tobacco on salivary pH between tobacco chewers, smokers and controls. Materials and Methods: A total of 60 subjects (males and females) aged 25-40 years, were divided equally into three groups: Tobacco smokers (Group A), chewers (Group B) and controls (Group C). Saliva of each subject was collected under resting condition. Salivary pH was determin... περισσότερα »
Basal cell adenoma of maxillary sinus mimicking ameloblastoma
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*Priya Anil Bhagde, Suresh Ramchandra Barpande, Jyoti Dilip Bhavthankar, Jayanti G Humbe* Journal of Oral and Maxillofacial Pathology 2016 20(1):142-146 Basal cell adenoma (BCA) is a rare basaloid tumor, with only 20% of cases occurring in minor salivary glands. Histologically, BCA is characterized by the presence of basaloid cells and may frequently be mistaken with canalicular adenoma, basal cell adenocarcinoma, adenoid cystic carcinoma and basaloid squamous cell carcinoma. Immunohistochemistry may aid in arriving at a final diagnosis as in the present case. Reported here is a ca...περισσότερα »
Interdevice interval on speech perception performance among bilateral, pediatric cochlear implant recipients
The effect of Objectives/Hypothesis To determine if prolongation of the interdevice interval in children receiving bilateral cochlear implants adversely affects speech perception outcomes. Study Design Retrospective chart review. Methods Retrospective review of our pediatric cochlear implant database was performed. Children who had undergone revision surgery or had less than 12 months listening experience with either the first or second implant were excluded. The interdevice interval, best Phonetically Balanced Kindergarten word lists (PBK) score from each ear, and demographic d... περισσότερα »
Ossicular chain reconstruction with glass ionomer cement
in pediatric patients via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Doğan Atan, Hüseyin Dere, Ali Rıza Yamur, Kürşat Murat Özcan ObjectiveThe aim of our study was to analyze the hearing results of ossicular chain reconstruction in incus long process defects in pediatric patients.MethodsThis retrospective study included 15 pediatric patients that had incus long process defect due to chronic otitis media or adhesive otitis, and repaired with glass ionomer cement ... περισσότερα »
Enlarged vestibular aqueduct syndrome (EVAS).Identification of a novel mutation in SLC26A4 gene
in a Chinese family with enlarged vestibular aqueduct syndrome via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Fengguo Zhang, Xiaohui Bai, Yun Xiao, Xue Zhang, Guodong Zhang, Jianfeng Li, Lei Xu, Haibo Wang ObjectiveTo investigate the genetic causes of hearing loss in a two generation Chinese family with enlarged vestibular aqueduct syndrome (EVAS).MethodsClinical and genetic evaluations were conducted in a deaf proband and her normal-hearing parents. Sanger sequ... περισσότερα »
Central lymph node metastasis in papillary thyroid cancer located in the isthmus
Clinicopathologic characteristics and pattern of central lymph node metastasis in papillary thyroid cancer located in the isthmus: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis The aim of this study was to evaluate the clinicopathologic characteristics and pattern of lymph node (LN) metastasis in papillary thyroid cancer (PTC) located in the isthmus. Study Design Retrospective cohort study. Methods One hundred ninety consecutive patients with PTC who underwent total thyroidectomy and bilateral central neck dissection were analyzed. Preoperative ultrasono...περισσότερα »
Threshold changes of ABR results
in toddlers and children via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Julia Louza, Daniel Polterauer, Natalie Wittlinger, Hanan Al Muzaini, Siiri Scheckinger, Martin Hempel, Maria Schuster IntroductionAuditory brainstem response (ABR) is a clinically established method to identify the hearing threshold in young children and is regularly performed after hearing screening has failed. Some studies have shown that, after the first diagnosis of hearing impairment i... περισσότερα »
Developmental delay in young children with sleep-disordered breathing
before and after tonsil and adenoid surgery via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Nira A. Goldstein, Michael Gorynski, Candice Yip, Jonathan Harounian, Harris Huberman, Jeremy Weedon ObjectiveOur objective was to determine the developmental status of young children with sleep-disordered breathing (SDB) as measured by the Ages and Stages Questionnaire (ASQ-3) and to evaluate improvement after treatment.MethodsThe ASQ-3 was completed at entry, 3 months an... περισσότερα »
Establishing a national paediatric radiology global outreach group recent developments in the British Society of Paediatric Radiology
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1NF4L8H via IFTTT
Study Calls for Reclassification of Thyroid Tumors as Non-Cancerous – Cancer Network
EndocrineWeb Study Calls for Reclassification of Thyroid Tumors as Non-Cancerous Cancer Network A new study is calling for a change in name for certain thyroid tumors. Patients diagnosed with what is currently known as noninvasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) have a very low risk for recurrence and … Common Thyroid Tumor… Continue reading Study Calls for Reclassification of Thyroid Tumors as Non-Cancerous – Cancer Network
Sidebar
(Source: National Association of the Deaf) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1SycKZC via IFTTT
Front
(Source: National Association of the Deaf) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1SycKsL via IFTTT
Hearing Aid Prices Under Pressure From Consumer Electronics
Less expensive and widely available devices can assist with hearing, but the hearing aid industry contends these products differ greatly from theirs. (Source: NYT Health) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Sg7LOo via IFTTT
Poly(ADP-ribosyl)ation of methyl CpG binding protein 2 regulates chromatin structure. Additions and Corrections
VOLUME 291 (2016) PAGES 4873–4881The title of the article was incorrect and has been corrected above. The correct title should read “Poly(ADP-ribosyl)ation of Methyl CpG Binding Protein 2 Regulates Chromatin Structure.” from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1YKjYLu via IFTTT
Breast Cancer Risk Factors among Ugandan Women at a Tertiary Hospital: A Case-Control Study
Background: Although East Africa, like other countries in sub-Saharan Africa, has a lower incidence of breast cancer than high-income countries, the disease rate is rising steeply in Africa; it has nearly tripled in the past few decades in Uganda. There is a paucity of studies that have examined the relation between reproductive factors and breast… Continue reading Breast Cancer Risk Factors among Ugandan Women at a Tertiary Hospital: A Case-Control Study
TORC2-Gad8 Regulates the MBF Complex Signal Transduction
The target of rapamycin (TOR) kinase is found at the core of two evolutionarily conserved complexes known as TOR complexes 1 and 2 (TORC1 and TORC2). In fission yeast, TORC2 is dispensable for proliferation under optimal growth conditions but is required for starvation and stress responses. We have previously reported that loss of function of… Continue reading TORC2-Gad8 Regulates the MBF Complex Signal Transduction
Analysis of the Relationship Between Response to Chemotherapy and Response to Radiation Therapy in Patients With Non-Small Cell Lung Cancer Receiving Sequential Treatment.
Objectives: We examine whether induction chemotherapy response predicts thoracic radiotherapy response in locally advanced or oligometastatic non-small cell lung cancer. Materials and Methods: Between January 2001 to August 2010, 25 consecutive patients were identified who received systemic dose chemotherapy followed by definitive thoracic radiotherapy alone. All patients had measurable disease after chemotherapy that was evaluable… Continue reading Analysis of the Relationship Between Response to Chemotherapy and Response to Radiation Therapy in Patients With Non-Small Cell Lung Can... περισσότερα »
Novel Endo-F3 Glycosynthases for Glycoprotein Synthesis Enzymology
Chemoenzymatic synthesis is emerging as a promising approach to the synthesis of homogeneous glycopeptides and glycoproteins highly demanded for functional glycomics studies, but its generality relies on the availability of a range of enzymes with high catalytic efficiency and well defined substrate specificity. We describe in this paper the discovery of glycosynthase mutants derived from… Continue reading Novel Endo-F3 Glycosynthases for Glycoprotein Synthesis Enzymology
KTP laser assisted endoscopic tissue fibrin glue biocauterization for congenital pyriform sinus fistula
in children via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Yun-Chen Huang, Steve Shinn-Forng Peng, Wei-Chung Hsu ObjectiveThis study aims to assess the efficacy of a novel endoscopic management for congenital pyriform sinus fistula (CPSF) using potassium titanyl phosphate (KTP) laser assisted endoscopic tissue fibrin glue biocauterization in children.MethodFrom 2010 to 2014, a total of 5 children with recurrent or acute suppurative thyroiditis or neck abscess se...περισσότερα »
Persistent tracheocutaneous fistulae
Coblation-assisted closure of via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): David L. Walner, Chris Mularczyk, Kedar Kakodkar Persistent tracheocutaneous fistulae (PTCFs) are sequelae of long-term tracheostomy tube use, and while many procedures exist to correct this issue, several are invasive and incur risk to the patient. This case study discusses a minimally invasive approach to closure of small PFTFs with a coblator device that may reduce the risks associa...περισσότερα »
Head and Neck Extranodal Interdigitating Dendritic Cell Sarcoma
Case Report and Review of the Literature: AbstractInterdigitating dendritic cell sarcoma (IDCS) is an exceedingly rare neoplasm originating from professional antigen presenting cells normally located in the T zone of the lymph node. The purpose of this report was to describe the first case of the IDCS of the submandibular gland and perform a review of the literature of head and neck IDCS. We present a case of an 81-year-old man with a 5 months history of slowly enlarging painless mass in right submandibular region. Fine needle aspiration cytology was suggestive of squamous cell car...περισσότερα »
Epithelioid Hemangioendothelioma of the Maxillary Sinus
Epithelioid Hemangioendothelioma of the Maxillary Sinus: AbstractThe clinical course and pathologic features of a 72 year old female who presented with epistaxis are presented. Radiographic findings were notable for a large, soft tissue lesion filling the maxillary sinus with significant bony erosion and expansion. The patient was ultimately diagnosed with epithelioid hemangioendothelioma (EHE) and underwent endoscopic resection. She has no evidence of local, regional or distant recurrence 14 months post-surgery. The rarity of this neoplasm, the unusual anatomic location and non-sp... περισσότερα »
Primary High-Grade Poorly Differentiated Angiosarcoma of an Intra-parotid Lymph Node
Primary High-Grade Poorly Differentiated Angiosarcoma of an Intra-parotid Lymph Node: AbstractHead and neck angiosarcoma is an infrequent malignant vascular tumor most commonly found in the skin and soft tissue of the head and neck. Most head and neck angiosarcomas are metastatic to cervical lymph nodes from other primitive location. We describe herein a case of primary high-grade poorly differentiated angiosarcoma arising in an intra-parotid lymph node, discuss the value of immunohistochemical stains for differential diagnosis, and review the literature concerning head and neck a...περισσότερα »
Oral Cavity Clear Cell Odontogenic Carcinoma
Oral Cavity Clear Cell Odontogenic Carcinoma: AbstractA case of clear cell odontogenic carcinoma of the oral cavity is described in this sine qua non radiology-pathology correlation article. CT demonstrated a solid and cystic mass arising from the mandible. Histology demonstrated variably-sized nests of clear to pale eosinophilic cells with occasional central necrosis embedded in a hyalinized to fibrocellular stroma. The specimen was also positive for the characteristic rearrangement of the EWSR1 (22q12) locus in 93.5 % of interphase cells.
Langerhans Cell Histiocytosis of the Temporal Bone
Langerhans Cell Histiocytosis of the Temporal Bone: AbstractLangerhans cell histiocytosis involving the temporal bone region is uncommon and can resemble malignant neoplasms on imaging due to high cellularity. Although recognizing the presence of sharp margins with beveled-edges can be helpful, tissue sampling is often necessary for confirming the diagnosis. Cytology classically demonstrates kidney-bean shaped nuclei within the Langerhans cells and immunohistochemical staining is positive for S-100, peanut agglutinin (PNA), MHC class II, CD1a, and Langerin (CD 207). These features ... περισσότερα »
Horner’s Syndrome Incidental to Medullary Thyroid Carcinoma Excision
Case Report and Brief Literature Review: Horner’s syndrome is characterized by a combination of ipsilateral miosis, blepharoptosis, enophthalmos, facial anhidrosis, and iris heterochromia in existence of congenital lesions. The syndrome results from a disruption of the ipsilateral sympathetic innervation of the eye and ocular adnexa at different levels. Though rare, thyroid and neck surgery could be considered as possible causes of this clinical entity. We present a case of Horner’s syndrome in a patient after total thyroidectomy and neck dissection for medullary thyroid cancer with... περισσότερα »
[Cervical macroadenoma causing hyperparathyroidism: Report of one case].
Related Articles *[Cervical macroadenoma causing hyperparathyroidism: Report of one case].* Rev Med Chil. 2015 Mar;143(3):396-400 Authors: Zapata P A, Delgado F J, González V G, Arteaga U E Abstract We report a 59-year-old man with a history of hypertension, recurrent renal stones and a severe hypercalcemia of 14.9 mg/dl with a serum phosphorus of 2.4 mg/dl and a serum albumin of 3.6 g/dl. Physical examination showed a 4 cm left cervical nodule, consistent with the diagnosis of thyroid nodule. Parathyroid hormone (PTH) levels were 844 pg/mL (normal 15-65 pg/ml) and a cervical ult... περισσότερα »
Thyroid nodule: first manifestation of chronic lymphocytic leukaemia.
Related Articles *Thyroid nodule: first manifestation of chronic lymphocytic leukaemia.* Arch Endocrinol Metab. 2015 Apr;59(2):190-4 Authors: Gonçalves A, Vale S, Nobre E, Barbosa AP, Piloto E, Wessling A, Mascarenhas M Abstract The presence of chronic lymphocytic leukaemia (CLL) cells in the thyroid gland is most likely due to a secondary involvement by a systemic disease. The reported incidence of CLL involving the thyroid is extremely low, representing about 3-4% of all thyroid lymphoproliferative neoplasm. We report a rare case of CLL presenting initially in the thyroid gland... περισσότερα »
INPP4B Is a PtdIns(345)P3 Phosphatase That Can Act as a Tumor Suppressor.
Related Articles *INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor.* Cancer Discov. 2015 Jul;5(7):730-9 Authors: Kofuji S, Kimura H, Nakanishi H, Nanjo H, Takasuga S, Liu H, Eguchi S, Nakamura R, Itoh R, Ueno N, Asanuma K, Huang M, Koizumi A, Habuchi T, Yamazaki M, Suzuki A, Sasaki J, Sasaki T Abstract UNLABELLED: Inositol polyphosphate 4-phosphatase B (INPP4B) has been identified as a tumor suppressor mutated in human breast, ovary, and prostate cancers. The molecular mechanism underlying INPP4B's tumor-suppressive role is currently unknown. Here, we d... περισσότερα »
[LONG-TERM RESULTS OF SURGICAL TREATMENT OF PATIENTS WITH FOLLICULAR TUMORS OF THE THYROID].
Related Articles *[LONG-TERM RESULTS OF SURGICAL TREATMENT OF PATIENTS WITH FOLLICULAR TUMORS OF THE THYROID].* Vestn Khir Im I I Grek. 2015;174(5):32-4 Authors: Zubarovskiy IN, Mikhailova MV, Osipenko SK Abstract The article analyzed an experience of treatment of 51 patients with follicular tumors. It was proved, that there weren't any complications and recurrences in case of typically performed operation and adequate replacement therapy in postoperative period. It was noted a good quality of life from 2 to 5 years. PMID: 26983255 [PubMed - indexed for MEDLINE] from pubmed: t... περισσότερα »
Partially Withdrawn Nasotracheal Tube: An Alternative to the Nasal Trumpet.
[image: http:--allenpress.com-system-files-image] Related Articles *Partially Withdrawn Nasotracheal Tube: An Alternative to the Nasal Trumpet.* Anesth Prog. 2015;62(4):166-7 Authors: Park YH, Choi YJ, Choi WC, Lee UL Abstract After 2-jaw surgery, difficulty in breathing through the mouth and the nose is common due to nasal airway obstruction, intraoral bleeding, and sometimes maxillomandibular fixation. A partially withdrawn nasotracheal tube can be used economically with equal efficacy to the nasopharyngeal airway to provide supplemental oxygen after 2-jaw surgery. PMID: 26650... περισσότερα »
The problems and pitfalls in systemic lupus erythematosus drug discovery.
Related Articles *The problems and pitfalls in systemic lupus erythematosus drug discovery.* Expert Opin Drug Discov. 2016 Apr 21; Authors: Rodríguez-Pintó I, Espinosa G, Cervera R PMID: 27100941 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1MMwl9p via IFTTT
The problems and pitfalls in systemic lupus erythematosus drug discovery.
Related Articles *The problems and pitfalls in systemic lupus erythematosus drug discovery.* Expert Opin Drug Discov. 2016 Apr 21; Authors: Rodríguez-Pintó I, Espinosa G, Cervera R PMID: 27100941 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1MMwl9p via IFTTT
Unilateral Cystic Parotid Lesion
in a Middle-Aged Man: A man had a left parotid gland lesion, with no associated pain, facial numbness, or weakness; computed tomography revealed a well-circumscribed ovoid lesion in the anterior aspect of the superficial lobe of the left parotid gland. What is your diagnosis? [image: First page PDF preview]
Diagnostic Tests for Pediatric Obstructive Sleep Apnea
The Need for Reliable and Effective *In Reply* I thank Dr Villa et al for their comments regarding our article and appreciate their bringing my attention to their work to develop and validate the sleep clinical record. I agree with these authors that, while sleep studies are considered to have the best combination of sensitivity and specificity to diagnose obstructive sleep apnea (OSA), their routine use to diagnose all children suspected of OSA is neither cost-effective nor feasible. [image: First page PDF preview]
Giant Cerebellar Lesion
in a Patient With Purulent Ear Drainage: A woman who had undergone an emergency craniotomy for brain decompression had purulent discharge from her right ear; imaging detected middle ear, mastoid, and infralabyrinthine involvement and meningitis and a large cerebellar lesion. What is your diagnosis? [image: First page PDF preview]
Screening and Follow-up of Children Who Snore When Polysomnography
Is Not Available: *To the Editor* We read with great interest the article titled “The Role of Sleep Studies in Children Who Snore” by Ishman. In this article the author reaffirmed the importance of performing polysomnography in children with suspected sleep disordered breathing (SDB) before and especially after treatment because the risk of persistent obstructive sleep apnea (OSA) after surgery is high. Moreover, the high cost and the limited availability of these studies is quite correctly pointed out by the author. It seems that there is no hope for these children to be studied if... περισσότερα »
HPV Vaccination Education
Efficacy of HPV Vaccination Education in a Diverse Urban Population: This prospective cohort study examines whether an educational platform affects knowledge, attitudes, and practices regarding human papillomavirus vaccination in an inner-city community. *Importance* Human papillomavirus (HPV) is a preventable disease that plays a causative role in a significant proportion of malignant neoplasms of the head and neck. Inner-city populations are at risk for HPV-related oropharyngeal cancer, are least likely to receive HPV vaccination, and report a lack of information regarding HPV... περισσότερα »
Synovial Cell Sarcoma of the Head and Neck
Synovial Cell Sarcoma of the Head and Neck: This analysis of SEER registry data examines factors associated with survival in patients with synovial cell sarcoma of the head and neck. *Importance* Synovial cell sarcoma of the head and neck (SCSHN) is a rare tumor associated with significant morbidity and mortality. The literature regarding these tumors is limited to case series and case reports. We used data from the population-based US Surveillance, Epidemiology, and End Results (SEER) cancer registry to determine factors affecting both overall survival and disease-specific surv... περισσότερα »
A correlative study of the levels of salivary Streptococcus mutans lactobacilli and Actinomyces with dental caries experience in subjects with mixed and permanent dentition
*Achala Chokshi, Pushpalatha Mahesh, P Sharada, Krunal Chokshi, S Anupriya, BK Ashwini* Journal of Oral and Maxillofacial Pathology 2016 20(1):25-28 Purpose: The aim of the study was to estimate the salivary levels of Streptococcus mutans, Lactobacilli and Actinomyces and to correlate it with dental caries experience in mixed and permanent dentition. Materials and Methods: The sample size comprised 110 subjects. The decayed, missing and filled teeth (DMFT) index of all the individuals participating in the study was calculated. Saliva samples were collected from patients and samples ...περισσότερα »
Role of inflammation in developmental odontogenic pathosis
*Sandeep S Gupta, Devi C Shetty, Aadithya B Urs, P Nainani* Journal of Oral and Maxillofacial Pathology 2016 20(1):164-164 Periapical infection in the primary tooth may lead to periapical abscess, granuloma, radicular cyst and even osteomyelitis. The infection in primary teeth can also affect the developing successor teeth leading to hypomineralization, hypoplasia, arrest of tooth development, regional odontodysplasia, delayed eruption etc. The purpose of this article is to report a case of malformed permanent tooth in relation to overlying infected deciduous teeth. The probable rol... περισσότερα »
Immunohistochemical expression of p53 and its clinicopathological correlation with modified Anneroth's histological grading system
*Kajal V Dave, Monali Chalishazar, Vishal R Dave, Pritam Panja, Manisha Singh, Tapan G Modi* Journal of Oral and Maxillofacial Pathology 2016 20(1):29-35 Introduction and Objectives: Oral squamous cell carcinoma (OSCC) is an epithelial neoplasm generally beginning as focal overgrowth of altered stem cells near the basement membrane, moving upward and laterally, replacing the normal epithelium. Histopathological grading has been used for many decades in an attempt to predict the clinical behavior of oral squamous cell carcinoma. In the present study, Forty biopsies were studied for ...περισσότερα »
Mounting ground sections of teeth: Cyanoacrylate adhesive versus Canada balsam
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
*Manogna R.L. Vangala, Amrutha Rudraraju, RV Subramanyam* Journal of Oral and Maxillofacial Pathology 2016 20(1):20-24 Introduction: Hard tissues can be studied by either decalcification or by preparing ground sections. Various mounting media have been tried and used for ground sections of teeth. However, there are very few studies on the use of cyanoacrylate adhesive as a mounting medium. Aims: The aim of our study was to evaluate the efficacy of cyanoacrylate adhesive (Fevikwik™) as a mounting medium for ground sections of teeth and to compare these ground sections with those moun... περισσότερα »
Compound composite odontoma
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
*G Girish, Radhika M Bavle, Manish Kumar Singh, Sahana N Prasad* Journal of Oral and Maxillofacial Pathology 2016 20(1):162-162 The term odontoma has been used as a descriptor for any tumor of odontogenic origin. It is a growth in which both epithelial and mesenchymal cells exhibits complete differentiation. Odontomas are considered as hamartomas rather than true neoplasm. They are usually discovered on routine radiographic examination. Odontomas, according to the World Health Organization, are classified into complex odontoma and compound odontomas. The present paper reports a case...περισσότερα »
A correlative study of the levels of salivary Streptococcus mutans lactobacilli and Actinomyces with dental caries experience in subjects with mixed and permanent dentition
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
*Achala Chokshi, Pushpalatha Mahesh, P Sharada, Krunal Chokshi, S Anupriya, BK Ashwini* Journal of Oral and Maxillofacial Pathology 2016 20(1):25-28 Purpose: The aim of the study was to estimate the salivary levels of Streptococcus mutans, Lactobacilli and Actinomyces and to correlate it with dental caries experience in mixed and permanent dentition. Materials and Methods: The sample size comprised 110 subjects. The decayed, missing and filled teeth (DMFT) index of all the individuals participating in the study was calculated. Saliva samples were collected from patients and samples ...περισσότερα »
Role of inflammation in developmental odontogenic pathosis
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
*Sandeep S Gupta, Devi C Shetty, Aadithya B Urs, P Nainani* Journal of Oral and Maxillofacial Pathology 2016 20(1):164-164 Periapical infection in the primary tooth may lead to periapical abscess, granuloma, radicular cyst and even osteomyelitis. The infection in primary teeth can also affect the developing successor teeth leading to hypomineralization, hypoplasia, arrest of tooth development, regional odontodysplasia, delayed eruption etc. The purpose of this article is to report a case of malformed permanent tooth in relation to overlying infected deciduous teeth. The probable rol... περισσότερα »
Immunohistochemical expression of p53 and its clinicopathological correlation with modified Anneroth's histological grading system
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
*Kajal V Dave, Monali Chalishazar, Vishal R Dave, Pritam Panja, Manisha Singh, Tapan G Modi* Journal of Oral and Maxillofacial Pathology 2016 20(1):29-35 Introduction and Objectives: Oral squamous cell carcinoma (OSCC) is an epithelial neoplasm generally beginning as focal overgrowth of altered stem cells near the basement membrane, moving upward and laterally, replacing the normal epithelium. Histopathological grading has been used for many decades in an attempt to predict the clinical behavior of oral squamous cell carcinoma. In the present study, Forty biopsies were studied for ...περισσότερα »
Combinatorial epigenetic deregulation by Helicobacter pylori and Epstein-Barr virus infections in gastric tumorigenesis
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Abstract Epigenetic mechanisms including DNA methylation, histone modifications, chromatin remodeling and microRNAs convert environmental signals to transcriptional outputs but are commonly hijacked by pathogenic microorganisms. Recent advances in cancer epigenomics have shed new light on the importance of epigenetic deregulation in *Helicobacter pylori*- and Epstein-Barr virus (EBV)-driven gastric tumorigenesis. Moreover, it is becoming apparent that epigenetic mechanisms interact through crosstalk and feedback loops, which modify global gene expression patterns. The SWI/SNF remo...περισσότερα »
EGFR inhibitors Identified as a Potential Treatment for Chordoma in a Focused Compound Screen
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
[image: cover.gif?v=1&s=8264a7b550f51cd866f84194] Abstract Chordoma is a rare malignant bone tumour with a poor prognosis and limited therapeutic options. We undertook a focused compound screen (FCS) against 1097 compounds on 3 well-characterised chordoma cell lines. 154 compounds were selected from the single concentration screen (1 μM) based on their growth inhibitory effect. Their half-maximal effective concentration (EC50) values were determined in chordoma cells and normal fibroblasts. Twenty-seven of these compounds displayed chordoma selective cell kill and 21/27 (78%) wer...περισσότερα »
Intraoperative Nerve Monitoring in Thyroid Surgery
Intraoperative Nerve Monitoring in Thyroid Surgery: This cross-sectional analysis uses data from the State Inpatient Databases to examine the use of intraoperative nerve monitoring and its association with patient and surgeon characteristics among patients undergoing thyroidectomy in 3 different states. *Importance* Intraoperative nerve monitoring (IONM) is increasingly performed during thyroid surgery. *Objective* To examine the use of IONM and its association with patient demographic characteristics and surgeon volume. *Design, Setting, and Participants* A cross-sectional ana... περισσότερα »
Rhinosinusitis and Parotid Enlargement
Rhinosinusitis and Parotid Enlargement: A young black man had progressive bilateral parotid swelling; radiologically, there were no masses or sialoliths, and his only associated symptoms were fevers and fatigue. What is your diagnosis? [image: First page PDF preview]
Cetuximab for Advanced Esophageal Squamous Cell Carcinoma
Cost-Effectiveness of by Vincent T. Janmaat, Marco J. Bruno, Suzanne Polinder, Sylvie Lorenzen, Florian Lordick, Maikel P. Peppelenbosch, Manon C. W. Spaander Background Costly biologicals in palliative oncology are emerging at a rapid pace. For example, in patients with advanced esophageal squamous cell carcinoma addition of cetuximab to a palliative chemotherapy regimen appears to improve survival. However, it simultaneously results in higher costs. We aimed to determine the incremental cost-effectiveness ratio of adding cetuximab to first-line chemotherapeutic treatment of p...περισσότερα »
Association of Caffeine and Hearing Recovery
Association of Caffeine and Hearing Recovery: This laboratory study assesses whether daily caffeine intake impairs hearing recovery in a guinea pig model of exposure to acoustic overstimulation events. *Importance* Noise-induced hearing loss is an increasingly worrisome problem. Although caffeine intake is common in people involved in noise-related environments, the effect of caffeine on the recovery of hearing after a temporary threshold shift requires further understanding. *Objectives* To determine whether caffeine impairs hearing recovery in a guinea pig model exposed to aco... περισσότερα »
Ethical Considerations When Counseling Patients With Thyroid Cancer
Ethical Considerations When Counseling Patients With Thyroid Cancer: [image: ole160001.pdf.gif] *To the Editor* In a recent Viewpoint, Stack and Angelos remind physicians about ethical obligations to outline risks, benefits, and alternatives of all treatment options to patients. Discussing the option of observation for papillary microcarcinoma (PMC), the authors assert that “this approach is not the standard of care in the United States,”(p957) and, if considered, should only be offered under an institutional review board–approved research protocol or if patients sign a “surveil... περισσότερα »
Ultrasonography-Guided Fine-Needle Aspiration
Accuracy of This study evaluates the use of ultrasonography-guided fine-needle aspiration to detect lymph node metastasis in patients with head and neck squamous cell carcinoma who completed chemoradiotherapy. *Importance* Few patients with persistent adenopathy following chemoradiotherapy (CRT) for head and neck squamous cell carcinoma harbor viable disease. Improved selectivity for surgical salvage is needed to prevent unnecessary salvage neck dissection. *Objective* To determine whether ultrasonography-guided fine-needle aspiration (FNA) can be used to identify viable cance... περισσότερα »
A white sessile lesion
A Laryngeal Lesion: [image: s_ocg150068f1.png] A woman in her 90s had worsening hoarseness; flexible nasolaryngoscopy revealed normal abduction and adduction of the vocal folds with a white sessile lesion starting at the right midfold on the superior and medial surfaces that crossed the midline to involve the entire left vocal fold. What is your diagnosis? [image: First page PDF preview]
Depression in Chronic Rhinosinusitis
Depression in Chronic Rhinosinusitis: This study examines depression-specific outcomes after medical or surgical treatment of chronic rhinosinusitis. *Importance* Depression is frequently undiagnosed in patients with chronic rhinosinusitis (CRS) and affects quality of life, productivity, and health care use. *Objective* To examine depression-specific outcomes after medical or surgical treatment of CRS. *Design, Setting, and Participants* A multi-institutional, prospective study of patients with refractory CRS treated at tertiary academic rhinology centers was performed from Ma... περισσότερα »
An Uncommon Lesion of the Otic Capsule
An Uncommon Lesion of the Otic Capsule: [image: s_ocg150060f1.png] A man in his 40s presented with a gradual-onset, left-sided hearing loss with a whistling tinnitus and occasional sharp otalgia; examination showed a smooth mass behind the left tympanic membrane. What is your diagnosis? [image: First page PDF preview]
Epithelioid hemangioendothelioma of the mandibular gingiva: A rare case of metastasis 4 years after radical excision and literature review
*Attilio Carlo Salgarelli, Pierantonio Bellini, Livia Maccio, Giacomo Setti* Journal of Oral and Maxillofacial Pathology 2016 20(1):137-141 Malignant epithelioid hemangioendothelioma (MEH), or high-risk epithelioid hemangioendothelioma, is a low- to intermediate-grade vascular malignancy. A few cases of MEH have been documented in the head and neck region, including the neck, thyroid gland, larynx and scalp. MEHs are extremely rare in the oral cavity. Only 31 cases of MEH in the oral cavity were described in English literature between 1975 and 2014. Further, only eleven cases were r... περισσότερα »
Cochlear Histopathologic Findings in Suppurative Labyrinthitis
Cochlear Histopathologic Findings in Suppurative Labyrinthitis: This study evaluates the effects of suppurative labyrinthitis on cochlear elements in archived human temporal bones. *Importance* Better understanding of the effects of suppurative labyrinthitis (SL) on cochlear elements will aid the development of new approaches to treat its sequelae and complications in the ear. *Objective* To quantitatively evaluate the effects of SL on cochlear elements in humans. *Design, Setting, and Participants* A comparative study was conducted at a tertiary academic medical center from Oc... περισσότερα »
Earplugs to Prevent Hearing Loss From Recreational Noise Exposure
Earplugs to Prevent Hearing Loss From Recreational Noise Exposure: This systematic review assesses the effect of earplugs at preventing hearing loss from exposure to recreational noise such as concerts. *Importance* The prevalence of hearing loss among children and adolescents is rising dramatically, caused mainly by increased exposure to recreational noise. *Objective* To present a systematic overview of the effectiveness of wearing earplugs to music venues, such as nightclubs and concert halls, to prevent hearing loss and tinnitus directly after exposure. *Evidence Acquisitio...περισσότερα »
Oral Fluid Intake and Adverse Outcomes After Pediatric Tonsillectomy
Oral Fluid Intake and Adverse Outcomes After Pediatric Tonsillectomy: This cohort study examines whether the quantity of oral fluid intake before discharge is associated with adverse outcomes following tonsillectomy in pediatric patients. *Importance* This study contributes novel data on the association between oral fluid intake before discharge and adverse outcomes following tonsillectomy in pediatric patients. These data contribute to evidence-based, safe, and cost-effective decision making regarding discharge. *Objective* To determine whether the quantity of oral fluid intak... περισσότερα »
Specialty-Specific National Surgical Quality Improvement Program
Specialty-Specific National Surgical Quality Improvement Program: [image: oic160002.pdf.gif] The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) was started by an act of the United States Congress in an attempt to decrease excessive mortality among patients within the Veterans Health Administration system. Currently, more than 200 hospitals participate in the ACS-NSQIP system. The focus of the program has been mainly on general surgery and vascular surgery procedures. A key part of ACS-NSQIP has been the recognition of the need for adjustme... περισσότερα »
Statistical Model for the Prediction of Common Vestibular Diagnoses
Statistical Model for the Prediction of Common Vestibular Diagnoses: This survey study develops a statistical model for predicting vestibular diagnoses, prior to clinical evaluation, from an intake questionnaire. *Importance* Treatment of patients with vestibular disorders can be complex, requires lengthy clinic visit time, and uses greater clinical resources for diagnosis. A pre-encounter intake questionnaire may predict the most common disorders, allowing for more efficient allocation of resources and use of clinicians. *Objective* To develop a statistical model for predicting... περισσότερα »
Complications in Pediatric Tonsillectomy and Adenoidectomy
Complications in Pediatric Tonsillectomy and Adenoidectomy: This database review compares rates of postoperative complications in pediatric patients undergoing tonsillectomy and adenoidectomy in inpatient vs ambulatory settings in the state of California. *Importance* A large-scale review is needed to characterize the rates of airway, respiratory, and cardiovascular complications after pediatric tonsillectomy and adenoidectomy (T&A) for inpatient and ambulatory cohorts. *Objective* To identify risk factors for postoperative complications stratified by age and operative facility ...περισσότερα »
Robotic Head and Neck Surgery
Morbidity and Mortality Associated With [image: s_old150002f1.png] This review of data from the Food and Drug Administration Manufacturer and User Facility Device Experience Database investigates the rates of morbidity and mortality associated with robotic head and neck surgery since 2009. [image: First page PDF preview]
Upper Airway Endoscopy to Evaluate Pediatric Pulmonary Aspiration
Upper Airway Endoscopy to Evaluate Pediatric Pulmonary Aspiration: This medical record review of children who experienced pulmonary aspiration at a tertiary referral children’s hospital assesses the ability of direct laryngoscopy and bronchoscopy under general anesthesia to detect aspiration-related airway lesions and identifies clinical characteristics associated with airway lesions. *Importance* There is no consensus on the evaluation of pediatric patients with aspiration. *Objectives* To determine the yield of direct laryngoscopy and bronchoscopy (DLB) using general anesthes... περισσότερα »
BLZ-100 and Identification of HNSCC and High-Risk Oral Dysplasia
BLZ-100 and Identification of HNSCC and High-Risk Oral Dysplasia: This study uses an orthotopic xenograft mouse model to examine BLZ-100 uptake in human HNSCC tumor xenografts and determine the sensitivity and specificity of this uptake. *Importance* Surgical cure of head and neck squamous cell carcinoma (HNSCC) remains hampered by inadequately resected tumors and poor recognition of lesions with malignant potential. BLZ-100 is a chlorotoxin-based, tumor-targeting agent that has not yet been studied in HNSCC. *Objective* To evaluate BLZ-100 uptake in models of HNSCC and oral d...περισσότερα »
Retropharyngeal Nodes in Treatment Deintensification
Retropharyngeal Nodes in Treatment Deintensification: [image: oic160001.pdf.gif] Treatment deintensification of human papillomavirus (HPV) associated oropharyngeal squamous cell cancer (OPSCC) is a topic of active debate. It is well recognized that HPV-associated OPSCC has unique tumor biological characteristics, reflected by a high propensity for nodal involvement and yet more favorable outcomes compared with HPV-negative OPSCC, with significantly improved overall survival and a reduced risk of recurrence. Because patients with HPV-associated OPSCC are often younger (
The American College of Surgeons National Surgical Quality Improvement Program for complex head and neck oncologic surgical procedures.
The Head and Neck–Reconstructive Surgery NSQIP: This study describes the adaptation of the American College of Surgeons National Surgical Quality Improvement Program for complex head and neck oncologic surgical procedures. *Importance* The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) serves the need for continual quality assessment in general surgery. Previously, no parallel mechanism specific to head and neck oncologic surgery existed. *Objective* To address the need for continual quality assessment in subspecialty surgery by adapting t... περισσότερα »
Long term scar quality in burns with three distinct healing potentials: A multicenter prospective cohort study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Abstract The laser Doppler imager is used in cases of indeterminate burn depth to accurately predict wound healing time at an early stage. The laser Doppler imager classifies burns into three estimated healing potentials as follows: high, <14 days; intermediate, 14-21 days; and low, >21 days. At this time, the relationship between these healing potentials […]
Altered ECM Deposition by Diabetic Foot Ulcer-Derived Fibroblasts Implicates Fibronectin in Chronic Wound Repair
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Abstract Current chronic wound treatments often fail to promote healing of diabetic foot ulcers (DFU), leading to amputation and increased patient morbidity. A critical mediator of proper wound healing is the production, assembly, and remodeling of the extracellular matrix (ECM) by fibroblasts. However, little is known about how these processes are altered in fibroblasts within […]
Genes Vol. 7 Pages 16: The R-Operon: A Model of Repetitive DNA-Organized Transcriptional Compartmentation of Eukaryotic Chromosomes for Coordinated Gene Expression
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
In eukaryotic genomes, it is essential to coordinate the activity of genes that function together to fulfill the same biological processes. Genomic organization likely plays a key role in coordinating transcription of different genes. However, little is known about how co-regulated genes are organized in the cell nucleus and how the chromosomal organization facilitates the […]
Kjentmann på siste etappe
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Han er lege for de døende, og mener man må ha en god plan for den siste tiden. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Sy85a2 via IFTTT
Stort løft for foreningen
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Det sier Christer Mjåset om lanseringen av Yngre legers forenings nye, digitale medlemsmagasin. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SA1mzG via IFTTT
Cancers Vol. 8 Pages 46: A Phase I Study of Unimolecular Pentavalent (Globo-H-GM2-sTn-TF-Tn) Immunization of Patients with Epithelial Ovarian Fallopian Tube or Peritoneal Cancer in First Remission
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
We conducted a phase I study in ovarian cancer patients to evaluate the safety and immunogenicity of a synthetic unimolecular pentavalent carbohydrate vaccine (Globo-H, GM2, sTn, TF, and Tn) supported on a peptide backbone, conjugated to keyhole limpet haemocyanin (KLH), and mixed with immunological adjuvant QS-21. Twenty-four advanced-stage, poor-risk, first-remission ovarian cancer patients were enrolled […]
Study Calls for Reclassification of Thyroid Tumors as Non-Cancerous – Cancer Network
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
EndocrineWeb Study Calls for Reclassification of Thyroid Tumors as Non-Cancerous Cancer Network A new study is calling for a change in name for certain thyroid tumors. Patients diagnosed with what is currently known as noninvasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) have a very low risk for recurrence and … Common Thyroid Tumor […]
Clinical Features of Food Allergy during the 1st Year of Life: The ADAPAR Birth Cohort Study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Background: Although food allergies (FAs) occur most commonly during the 1st year of life, there is limited information available regarding the epidemiology of FAs. In this study, we investigated the incidence of FA and the associated risk factors during the 1st year of life in southeast Turkey. Methods: This study is a prospective evaluation of […]
Breast Cancer Risk Factors among Ugandan Women at a Tertiary Hospital: A Case-Control Study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Background: Although East Africa, like other countries in sub-Saharan Africa, has a lower incidence of breast cancer than high-income countries, the disease rate is rising steeply in Africa; it has nearly tripled in the past few decades in Uganda. There is a paucity of studies that have examined the relation between reproductive factors and breast […]
Targeted missiles against aggresive cancer cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Targeted missiles that can enter cancer cells and deliver lethal cell toxins without harming surrounding healthy tissue has been a long-standing vision in cancer research, but it has proved difficult to accomplish. A research group at Lund University… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QrEc6P via IFTTT
Rapidly Growing Vascular Mass Within the Thyroid
Rapidly Growing Vascular Mass Within the Thyroid: [image: s_ocg150058f1.png] A woman with multinodular goiter was referred for exertional dyspnea and chest discomfort; CT revealed significant growth in a small time interval, and PET/CT was showed increased metabolic activity in the mass. What is your diagnosis?
Advanced Oropharyngeal Squamous Cell Carcinoma Treatment Algorithm
Advanced Oropharyngeal Squamous Cell Carcinoma Treatment Algorithm: This study evaluates the prevalence of pathologic retropharyngeal adenopathy in oropharyngeal squamous cell carcinoma relative to involvement of the oropharyngeal subsite, number of metastatic neck nodes, T classification, and N classification. *Importance* Understanding the drainage patterns to the retropharyngeal lymph nodes is an important consideration in oropharyngeal squamous cell carcinoma (OPSCC) because treatment of these nodes is related to increased morbidity. Prediction of these drainage patterns cou...περισσότερα »
Ethical Considerations When Counseling Patients With Thyroid Cancer
Ethical Considerations When Counseling Patients With Thyroid Cancer: [image: olr160001.pdf.gif] *In Reply* We stand by our statement in our article,(p957) referring to observation of known thyroid cancers, that “at the present time, this approach is not the standard of care in the United States.” We are currently witnessing many paradigm shifts in US clinical oncology with respect to approaches to breast and prostate cancer. Whether an observational shift occurs in thyroid cancer remains to be seen. Therefore, in the interim, we think the observation of thyroid or any other canc... περισσότερα »
Modified technique of functional vertical hemilaryngectomy for cancer invading 1 hemicricoid
Modified technique of functional vertical hemilaryngectomy for cancer invading 1 hemicricoid: Abstract Background Partial laryngectomy techniques are challenging, especially in young patients where function has to be preserved without compromising the oncologic outcome. We present a modified laryngectomy technique indicated for tumors invading one hemicricoid. Methods Vertical hemilaryngectomy with reconstruction of neo-glottis by hemi trachea and placement of an endolaryngeal silicon prosthesis for a 21-y old female patient presenting with a synovial sarcoma located on the left ar...περισσότερα »
Evaluation of nasal patency by VAS/NOSE questionnaires and anterior active rhinomanometry after septoplasty: a retrospective one-year follow-up cohort study
Evaluation of nasal patency by VAS/NOSE questionnaires and anterior active rhinomanometry after septoplasty: a retrospective one-year follow-up cohort study: Abstract Objective To assess the efficacy of septoplasty and the correlation between the subjective evaluations of a visual analogue scale (VAS) and the Nasal Obstruction Symptom Evaluation (NOSE) questionnaire and active anterior rhinomanometry of the nasal airway after septoplasty. Design A retrospective, individual cohort study Setting Ear, Nose, and Throat Department, Taipei City Hospital, Taipei, Taiwan. Participants Fifty ...περισσότερα »
Radiofrequency Ablation Versus Endoscopic Submucosal Dissection in Treating Large Early Esophageal Squamous Cell Neoplasia.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Authors: Wang WL, Chang IW, Chen CC, Chang CY, Mo LR, Lin JT, Wang HP, Lee CT Abstract Radiofrequency ablation (RFA) and endoscopic submucosal dissection (ESD) can potentially be applied for early esophageal squamous cell neoplasia (ESCN); however, no study has directly compared these 2 modalities.We retrospectively enrolled the patients with flat-type "large" (length ≥3 cm extending ≥1/2 of the circumference of esophagus) early ESCNs treated endoscopically. The main outcome measurements were complete response at 12 months, and a... περισσότερα »
Oculoauriculovertebral spectrum (OAVS) malformations based on Katsumata’s asymmetry index
Three-dimensional CT evaluation of oculoauriculovertebral spectrum patients use of Katsumata’s asymmetry index: Abstract ObjectivesTo evaluate patients with oculoauriculovertebral spectrum (OAVS) malformations based on Katsumata’s asymmetry index and to assess the usefulness of the scores thus obtained in identifying degrees and sites of asymmetry. MethodsMultislice spiral computed tomography (MSCT) datasets of 8 female and 12 male OAVS patients aged 5.7–23.9 years were retrospectively analyzed. After three-dimensional reconstruction, central and bilateral anatomical landmarks ...περισσότερα »
Long term scar quality in burns with three distinct healing potentials: A multicenter prospective cohort study
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Abstract The laser Doppler imager is used in cases of indeterminate burn depth to accurately predict wound healing time at an early stage. The laser Doppler imager classifies burns into three estimated healing potentials as follows: high, <14 days; intermediate, 14-21 days; and low, >21 days. At this time, the relationship between these healing potentials […]
Altered ECM Deposition by Diabetic Foot Ulcer-Derived Fibroblasts Implicates Fibronectin in Chronic Wound Repair
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Abstract Current chronic wound treatments often fail to promote healing of diabetic foot ulcers (DFU), leading to amputation and increased patient morbidity. A critical mediator of proper wound healing is the production, assembly, and remodeling of the extracellular matrix (ECM) by fibroblasts. However, little is known about how these processes are altered in fibroblasts within […]
re: re: cheap and trackable website traffic
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα
Loading *Full Details * Special offer USA mostly targeted traffic GA Trackable traffic Good Bounce rate Campaigns start in 2-3 hours 125000 visits for only 20 usd. For Full Details please read the attached .html file Best regards Gabriela Resler Unsubscribe option is available on the footer of our website
Septicemia with Streptococcus pseudopneumoniae: report of three cases with an apparent hepatic or bile duct association
10.3109/23744235.2016.1157896<br>Kurt Fuursted from Infection via ola Kala on Inoreader http://ift.tt/1SA033N via IFTTT
Long term scar quality in burns with three distinct healing potentials: A multicenter prospective cohort study
[image: cover.gif?v=1&s=00eca2b4f3bb0b83a2b9cbac] Abstract The laser Doppler imager is used in cases of indeterminate burn depth to accurately predict wound healing time at an early stage. The laser Doppler imager classifies burns into three estimated healing potentials as follows: high, <14 days; intermediate, 14-21 days; and low, >21 days. At this time, the relationship between these healing potentials and long-term scar quality is unknown. The objective of this study was to determine the long-term scar quality of burns with three distinct healing potentials. The secondary obje...περισσότερα »
Altered ECM Deposition by Diabetic Foot Ulcer-Derived Fibroblasts Implicates Fibronectin in Chronic Wound Repair
[image: cover.gif?v=1&s=00eca2b4f3bb0b83a2b9cbac] Abstract Current chronic wound treatments often fail to promote healing of diabetic foot ulcers (DFU), leading to amputation and increased patient morbidity. A critical mediator of proper wound healing is the production, assembly, and remodeling of the extracellular matrix (ECM) by fibroblasts. However, little is known about how these processes are altered in fibroblasts within the DFU microenvironment. Thus, we investigated the capacity of multiple, primary DFU-derived fibroblast strains to express, produce, and assemble ECM prot... περισσότερα »
