Psychiatric disorders in skin-restricted lupus
High prevalence of psychiatric disorders in skin-restricted lupus patients: a case-controlled study Background Psychiatric disorders have been extensively documented in patients with systemic lupus erythematosus. However, the prevalence of psychiatric disorders in skin-restricted lupus (SRL) patients remains unknown although SRL is more common than SLE. Objectives To assess current and lifetime prevalence of Axis I psychiatric disorders among SRL outpatients and to examine the factors associated with psychiatric disorders among such patients. Methods Multicentre case-control study i...περισσότερα »
Pruritus in Primary Localised Cutaneous Amyloidosis
Pathophysiology of Background Primary localised cutaneous amyloidosis (PLCA) is a chronic pruritic dermatosis prevalent among the Southern Chinese and South Americans. Pruritus is frequently present and can be debilitating; its pathophysiology is largely unknown. Objective To investigate if small-fibre neuropathy, which results in reduction of intra-epidermal nerve fibres (IENF) and abnormalities in quantitative thermal sensory testing (QST), is present in PLCA. Methods Twenty Chinese patients (10 males) and 20 ethnic-, gender- and age-matched controls underwent QST assessments. The...περισσότερα »
Pyoderma gangrenosum (PG) acne and suppurative hidradenitis (SH) (PASH) syndrome
PSTPIP1 Gene mutation in a pyoderma gangrenosum, acne and suppurative hidradenitis (PASH) Syndrome Pyoderma gangrenosum (PG) acne and suppurative hidradenitis (SH) (PASH) syndrome is a recently described condition which belongs to the spectrum of autoinflammatory diseases (AIDs). 1 AIDs are a group of heterozygous disorders characterized by disregulation of the innate immune response. 2 PSTPIP1 gene mutations affecting proteins of the inflammasome complex or proteins that regulate it′s function, responsible for the inflammatory pathway, are associated with AIDs. This article is prote... περισσότερα »
Hair dye product containing 2-methoxymethyl-p-phenylenediamine
Continuous usage of a hair dye product containing 2-methoxymethyl-p-phenylenediamine by hair dye allergic individuals Background Despite a positive patch test reaction to p-phenylenediamine (PPD) and/or toluene-2,5-diamine (PTD) many people attempt to continue dyeing their hair with products containing PPD or its derivatives. Objectives Investigation of elicitation reactions among PPD/PTD allergic individuals to hair dye products containing the less-sensitizing PPD-derivative 2-methoxymethyl-p-phenylenediamine (ME-PPD). Methods: Elicitation reactions were studied in 43 PPD/PTD allerg...περισσότερα »
UV exposure from indoor tanning devices
: A systematic review Use of indoor tanning devices increases the risk of cutaneous melanoma and non-melanoma skin cancer. Indoor tanning devices have become important sources of ultraviolet (UV) exposure, both UVB and UVA. This systematic review assessed UV measurements performed in indoor tanning devices related to irradiance level, wavelength distribution and to the similarities to natural sun. The study was performed in accordance with the MOOSE and PRISMA guidelines. We searched PubMed, EmBase and Web of Science from inception through May 2015, and also examined the reference li... περισσότερα »
Topical brimonidine tartrate gel 0.33% effectively reduces the post treatment erythema of daylight-activated photodynamic therapy
Topical brimonidine tartrate gel 0.33% effectively reduces the post treatment erythema of daylight-activated photodynamic therapy With great interest we have read the articles of Petersen et al. and Wiegell et al. concerning the development of erythema following daylight-activated photodynamic therapy (PDT). Recently, daylight-activated PDT (DL-PDT) has been introduced as an attractive alternative for conventional PDT (cPDT). This article is protected by copyright. All rights reserved.
Primary amelanotic rhabdoid melanoma of the forehead
Primary amelanotic rhabdoid melanoma of the forehead Pathologists in general and dermatopathologist in particular are very well aware that melanomas can virtually mimic any type of cancer due to its huge versatility to adopt many cytomorphological and architectural variants1. In 1992, rhabdoid variant of melanoma was first described by Bittesini et al.2, which is considered an extremely rare variant of malignant melanoma, better observed in metastatic cases rather than primary melanomas3. Histopathologically is characterized by the presence of large sheets or nests of polygonal tumor...περισσότερα »
British Journal of Dermatology
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 4 δευτερόλεπτα
Immunobullous disease and ulcerative colitis: the need of an accurate diagnosis In their paper entitled ‘‘Immunobullous disease and ulcerative colitis: a case series of six patients”, Sotiriou and cols1 describe six patients with different immunobullous diseases and concomitant ulcerative colitis. In case 1, linear IgA bullous dermatosis (LABD) diagnosis was made exclusively by histopathologic and direct immunofluorescence findings. This article is protected by copyright. All rights reserved. Reply to: Validation of database search strategies for the epidemiological study of pemphig... περισσότερα »
Crisaborole Topical Ointment, 2% in Adolescents with Atopic Dermatitis
Pharmacokinetic Profile, Safety, and Tolerability of Crisaborole Topical Ointment, 2% in Adolescents with Atopic Dermatitis: An Open-Label Phase 2a Study: Abstract Background Phosphodiesterase-4 (PDE4) is an emerging target in treating inflammatory skin diseases. Crisaborole topical ointment, 2% is a novel, boron-based, topical PDE4 inhibitor under investigation for treatment of mild to moderate atopic dermatitis (AD). Methods Adolescent patients aged 12 to 17 years with treatable AD lesions involving ≥10% to ≤35% body surface area (BSA) were enrolled into a phase 2a, open-label st...περισσότερα »
Humoral Immune Response Against Human Papillomavirus as Source of Biomarkers for the Prediction and Detection of Cervical Cancer
Humoral Immune Response Against Human Papillomavirus as Source of Biomarkers for the Prediction and Detection of Cervical Cancer: Viral Immunology , Vol. 0, No. 0. Author information Lourdes Gutierrez-Xicotencatl,1 Dolores Azucena Salazar-Piña,1 Adolfo Pedroza-Saavedra,1 Lilia Chihu-Amparan,1 Angelica Nallelhy Rodriguez-Ocampo, 2 Minerva Maldonado-Gama,1 and Fernando Roger Esquivel-Guadarrama3 1Centro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México. 2Unidad Académica de Ciencias Químico Biológicas y Farmacia, Universi... περισσότερα »
Chronic stress and oral cancer research: Disregarded aspects in animal model studies
Chronic stress and oral cancer research: Disregarded aspects in animal model studies: Xie et al. illustrated the effects of chronic physical stress on an animal model. The authors demonstrated that stress-related mediators (catecholamine and glucocorticoid) can enhance the production of angiogenic cytokines VEGF and MMP-2 [1]. We would like to take this opportunity to discuss some of the issues associated with oral cancer research and stress in animal model studies.
Comparative effectiveness of induction chemotherapy for oropharyngeal squamous cell carcinoma: A population-based analysis
Comparative effectiveness of induction chemotherapy for oropharyngeal squamous cell carcinoma: A population-based analysis: The optimal non-surgical treatment for locally advanced oropharyngeal squamous cell carcinoma (OPSCC) is frequently contested [1]. Although definitive chemoradiotherapy (CRT) has largely become the standard-of-care, several older randomized trials suggested that induction chemotherapy (IC) improves survival over radiotherapy (RT) alone [2,3], and IC proponents further point to high response rates with modern regimens [4] and a significant reduction in distant m...περισσότερα »
Is p16-positive oropharyngeal squamous cell carcinoma associated with favorable prognosis? A systematic review and meta-analysis
Is p16-positive oropharyngeal squamous cell carcinoma associated with favorable prognosis? A systematic review and meta-analysis: Squamous cell cancers of the head and neck as a group represent the sixth most common malignancy worldwide [1]. While the overall incidence of head and neck cancers (HNC) at various anatomic subsites such as the ventrolateral tongue and floor of mouth has decreased in conjunction with reduced smoking and drinking rates, oropharyngeal squamous cell carcinomas (OPSCC) have increased mainly due to high-risk human papillomavirus (HPV) infection [2]. HPV is a ...περισσότερα »
Eyelid fat grafting: indications, operative technique and complications; a systematic review
Eyelid fat grafting: indications, operative technique and complications; a systematic review: Many recent studies concerning autologous fat grafting in the eyelids have been published, mostly consisting of case reports and retrospective case series. However, no study on the overall complication or satisfaction rate associated with the various grafting techniques exists. We performed a comprehensive literature review to determine the outcomes and complications of eyelid fat grafting, as well as patient satisfaction.
Accidental intraoral injection of formalin during extraction
Accidental intraoral injection of formalin during extraction: case report: Transparent, clear solutions such as hydrogen peroxide, alcohol, sodium hypochlorite, formaldehyde, and local anaesthetics are widely used in dentistry, so the tissues are liable to accidental injury. Formalin, a 37%-40% solution of formaldehyde, is extensively used in 10% solution as a tissue preservative, but it has toxic effects on systems such as the gastrointestinal tract, respiratory tract, skin, and mucosa. However, we know of few reports of cases of inadvertent injection of alcohol and formalin direct... περισσότερα »
Use of pentoxifylline and tocopherol in the management of osteoradionecrosis
Use of pentoxifylline and tocopherol in the management of osteoradionecrosis: Osteoradionecrosis (ORN) is a complication of radiotherapy, and is difficult to manage once established. However, its pathogenesis has been reinvestigated, and it is now thought to be potentially amenable to treatment with pentoxifylline and tocopherol (vitamin E). We made a retrospective analysis of 62 patients with established ORN who were treated in this way. When only pentoxifylline and vitamin E was used ORN resolved in 14/25 (56%) but paradoxically, when it was combined with antibiotics, only 6/22 re... περισσότερα »
Primary ciliary body carcinoma
Paraneoplastic syndrome – unresponsive systemic hypertension and fever as expression of primitive ciliary body carcinoma in a blind painful eye: a case report: Background: The purpose of this study was to present a case of paraneoplastic systemic hypertension and fever in an undiagnosed primary ciliary body carcinoma arising in a painful blind eye.Case presentationA 37-year-old white man with a history of blindness since childhood was enucleated for neovascular glaucoma because of intractable pain in his right eye. A histopathological examination revealed a ciliary body carcinoma. On...περισσότερα »
Warfarin-induced calciphylaxis
Warfarin-induced calciphylaxis: Description A 76-year-old woman, with a history of hypertension and atrial fibrillation, was admitted to our hospital for sepsis secondary to necrotic skin lesions. The patient had a 6-month history of non-healing necrotic skin ulcers affecting her lower extremities. She reported that her symptoms had begun 1 month after she had started taking warfarin 5 mg daily for atrial fibrillation. The lesions first started as blisters, which then burst and became painful ulcers. The patient was then seen by her primary care provider who recommended wound care a... περισσότερα »
Takayasu's arteritis and primary antiphospholipid syndrome presenting as hypertensive urgency
Takayasu's arteritis and primary antiphospholipid syndrome presenting as hypertensive urgency: A 33-year-old Caucasian man was admitted to the hospital with chest pain and hypertensive urgency. Physical examination revealed widespread arterial bruits and marked difference in blood pressure between the upper limbs. Vascular imaging showed widespread narrowing in multiple vascular territories. He met the established American College of Rheumatology criteria for Takayasu's arteritis. His resistant hypertension was considered to be a consequence of bilateral renal artery stenosis and h...περισσότερα »
A 1.5 cm right cervical lymph node and a 0.9x0.9 cm scalp nodule
Cutaneous metastasis: a rare herald of a silent cancer: A 59-year-old previously healthy man with a 50-pack-year smoking history presented with rib pain 1 month after a mechanical fall. Physical examination revealed a 1.5 cm right cervical lymph node and a 0.9x0.9 cm scalp nodule. The patient had only noticed the scalp lesion a month prior to presentation. Chest X-ray revealed a 5.8x5.0 cm left infrahilar mass. CT angiography demonstrated extensive metastatic mediastinal and right hilar adenopathy as well as hepatic, right adrenal and brain lesions. Pathology from fine-needle aspir... περισσότερα »
Immediate and non-immediate allergic reactions to amoxicillin present a diagnostic dilemma: a case series
Immediate and non-immediate allergic reactions to amoxicillin present a diagnostic dilemma: a case series: Background: Allergic reactions to amoxicillin are very common occurrences in the pediatric age group; however, onset of symptoms can present a diagnostic dilemma.Case presentationWe present a case series that describes three children (8-year-old white girl, 2-year-old white boy and 14-month-old Chinese boy) who presented with varied onset of allergic reactions to amoxicillin, specifically immediate (within the first hour after exposure) and non-immediate onset. One child develop... περισσότερα »
Randomized controlled trial of the CGRP receptor antagonist telcagepant for prevention of headache in women with perimenstrual migraine
Randomized controlled trial of the CGRP receptor antagonist telcagepant for prevention of headache in women with perimenstrual migraine: Aim The aim of this article is to evaluate the safety and efficacy of perimenstrual telcagepant, a CGRP receptor antagonist, for headache prophylaxis. Methods We conducted a randomized, double-blind, placebo-controlled, six-month trial in women with migraine for ≥3 months who experienced perimenstrual headaches. Women were randomized to telcagepant 140 mg or placebo (2:1 ratio) for seven consecutive days perimenstrually. Safety was assessed by ad... περισσότερα »
Increased interictal visual network connectivity in patients with migraine with aura
Increased interictal visual network connectivity in patients with migraine with aura: Objective To evaluate the resting-state visual network functional connectivity in patients with migraine with aura and migraine without aura during the interictal period. Population and methods Using resting-state functional magnetic resonance imaging, the resting-state visual network integrity was investigated in 20 patients with migraine with aura, 20 age- and sex-matched patients with migraine without aura and 20 healthy controls. Voxel-based morphometry and diffusion tensor imaging were used ... περισσότερα »
Intravenous dexketoprofen vs placebo for migraine attack in the emergency department: A randomized, placebo-controlled trial
Intravenous dexketoprofen vs placebo for migraine attack in the emergency department: A randomized, placebo-controlled trial: Objective Migraine is a leading headache etiology that frequently presents to the emergency department (ED). In the present study, we aimed to determine the efficacy of dexketoprofen in aborting migraine headaches in the ED. Methods This prospective, randomized, double-blind study was conducted in an ED of a tertiary care hospital using allocation concealment. Patients were allocated into two arms to receive the study drug; 50 mg dexketoprofen in 50 ml salin...περισσότερα »
A better-ventilated ocean triggered by Late Cretaceous changes in continental configuration
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Article In the Earth’s history, the timing of oceanic large-scale events of oxygen depletion remains poorly understood. Here, the authors show that palaeogeography was a major preconditioning factor during the Cretaceous, implying that thresholds to shift toward a global anoxia are likely to be much higher at present. Nature Communications doi: 10.1038/ncomms10316 Authors: Yannick Donnadieu, […]
So gehen Sie bei Palpitationen auf Nummer sicher!
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Praxistipps vom Kardiologen Der Patient klagt über „Herzstolpern“: Wie gehen Sie nun vor? Reichen klinische Untersuchung, Bluttests und EKG, oder empfiehlt sich die Überweisung an den Facharzt? Zwei britische Kardiologen geben nützliche Praxistipps, vor allem auch für das Patientengespräch. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Pd1Gmf via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete […]
Nocardiopsis mwathae sp. nov., isolated from the haloalkaline Lake Elmenteita in the African Rift Valley
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Abstract During a screening for novel and biotechnologically useful bacteria in haloalkaline lakes, strain No.156T was isolated from a sediment sample from lake Elmenteita in the African Rift Valley and studied by a polyphasic taxonomic approach. The strain was observed to form yellow aerial and substrate mycelia; optimal growth was found to be at 30–35 […]
Colorectal clinical trials: what is on the horizon?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lpvi1N via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Putative role of SUMOylation in controlling the activity of deubiquitinating enzymes in cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lpvi1B via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Efficacious and safe orotracheal intubation for laboratory mice using slim … – BMC Blogs Network
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
Efficacious and safe orotracheal intubation for laboratory mice using slim … BMC Blogs Network Tracheal intubation of laboratory mice remains essential yet challenging for most researchers. The aim of this study was to investigate whether this procedure can be more efficiently and safely accomplished by a novel method using slim and torqueable … from #AlexandrosSfakianakis […]
Burden of Nursing Home-Onset Clostridium difficile Infection in the United States: Estimates of Incidence and Patient Outcomes
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
Background. Approximately 4 million Americans receive nursing home (NH) care annually. Nursing home residents commonly have risk factors for Clostridium difficile infection (CDI), including advanced age and antibiotic exposures. We estimated national incidence of NH-onset (NHO) CDI and patient outcomes. Methods. We identified NHO-CDI cases from population-based surveillance of 10 geographic areas in the United […]
Indian Journal of Gender Studies
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
Indian Journal of Gender Studies, published by SAGE Publications, last updated on 2016-01-18, available at http://ijg.sagepub.com from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ijg.sagepub.com/ via IFTTT
Energy Exploration & Exploitation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
Energy Exploration & Exploitation, published by SAGE Publications, last updated on 2016-01-18, available at http://eea.sagepub.com from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://eea.sagepub.com/ via IFTTT
Verbatim: America launches a new war on cancer – Dubuque Telegraph Herald
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
Verbatim: America launches a new war on cancer Dubuque Telegraph Herald But, ominously, some cancers still are on the rise, including certain types of leukemia and cancers of the tongue, tonsil, small intestine, liver, pancreas, kidney and thyroid. Biden says he will «seize the moment» to push for a cure. He promises a … from […]
The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
Abstract Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis-metaplasia-dysplasia-adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE/EAC sequence remains mainly unknown. In this study we analyzed three […]
The function of the two-pore channel TPC1 depends on dimerization of its carboxy-terminal helix
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
Abstract Two-pore channels (TPCs) constitute a family of intracellular cation channels with diverse permeation properties and functions in animals and plants. In the model plant Arabidopsis, the vacuolar cation channel TPC1 is involved in propagation of calcium waves and in cation homeostasis. Here, we discovered that the dimerization of a predicted helix within the carboxyl-terminus […]
TUFM downregulation induces epithelial–mesenchymal transition and invasion in lung cancer cells via a mechanism involving AMPK-GSK3β signaling
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
Abstract Mitochondrial dysfunction and epithelial-to-mesenchymal transition (EMT) play important roles in cancer development and metastasis. However, very little is known about the connection between mitochondrial dysfunction and EMT. Tu translation elongation factor, mitochondrial (TUFM), a key factor in the translational expression of mitochondrial DNA, plays an important role in the control of mitochondrial function. Here, […]
A framework for detecting unfolding emergencies using humans as sensors
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
The advent of online social networks (OSNs) paired with the ubiquitous proliferation of smartphones have enabled social sensing systems. In the last few years, the aptitude of humans to spontaneously collect and timely share context information has been exploited for emergency detection and crisis management. Apart from event-specific features, these systems share technical approaches and […]
Verbatim: America launches a new war on cancer – Dubuque Telegraph Herald
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
Verbatim: America launches a new war on cancer Dubuque Telegraph Herald But, ominously, some cancers still are on the rise, including certain types of leukemia and cancers of the tongue, tonsil, small intestine, liver, pancreas, kidney and thyroid. Biden says he will «seize the moment» to push for a cure. He promises a … from […]
Burden of Nursing Home-Onset Clostridium difficile Infection in the United States: Estimates of Incidence and Patient Outcomes
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
Background. Approximately 4 million Americans receive nursing home (NH) care annually. Nursing home residents commonly have risk factors for Clostridium difficile infection (CDI), including advanced age and antibiotic exposures. We estimated national incidence of NH-onset (NHO) CDI and patient outcomes. Methods. We identified NHO-CDI cases from population-based surveillance of 10 geographic areas in the United […]
Computerized tomography-guided sphenopalatine ganglion pulsed radiofrequency treatment in 16 patients with refractory cluster headaches: Twelve- to 30-month follow-up evaluations
Computerized tomography-guided sphenopalatine ganglion pulsed radiofrequency treatment in 16 patients with refractory cluster headaches: Twelve- to 30-month follow-up evaluations: Background Sphenopalatine ganglion percutaneous radiofrequency thermocoagulation treatment can improve the symptoms of cluster headaches to some extent. However, as an ablation treatment, radiofrequency thermocoagulation treatment also has side effects. Objective To preliminarily evaluate the efficacy and safety of a non-ablative computerized tomography-guided pulsed radiofrequency treatment of sphenopal...περισσότερα »
The use of the 25 Sprotte needle markedly reduces post-dural puncture headache in routine neurological practice
The use of the 25 Sprotte needle markedly reduces post-dural puncture headache in routine neurological practice: Objectives The objectives of this article are to test the feasibility of lumbar puncture (LP) using 25-gauge (G) needles in daily neurological practice and to compare the risk of post-dural puncture headache (PDPH) with four types of needles. Methods In a prospective rater-blind study, pros and cons of four different LP needles, the 20G Quincke (20Q), 22G Sprotte (22S), 25G Whitacre (25W) and 25G Sprotte (25S), were evaluated in 394 LPs performed by seven neurologists. ... περισσότερα »
Robotic Rehabilitator of the Rodent Upper Extremity: A System and Method for Assessing and Training Forelimb Force Production after Neurological Injury
Journal of Neurotrauma , Vol. 0, No. 0. from Neurology via xlomafota13 on Inoreader http://ift.tt/1U8Ilk3 via IFTTT
Structural connectivity analyses in motor recovery research after stroke
Abstract Structural connectivity analyses by means of diffusion-weighted imaging have substantially advanced the understanding of stroke-related network alterations and their implications for motor recovery processes and residual motor function. Analyses of the corticospinal tract, alternate corticofugal pathways as well as intrahemispheric and interhemispheric corticocortical connections have not only been related to residual motor function in cross-sectional studies, but have also been evaluated to predict functional recovery after stroke in longitudinal studies. This review wil... περισσότερα »
Detoxification in medication-overuse headache, a retrospective controlled follow-up study: Does care by a headache nurse lead to cure?
Detoxification in medication-overuse headache, a retrospective controlled follow-up study: Does care by a headache nurse lead to cure?: Aim The aim of this article is to determine whether support by a headache nurse in the treatment of medication-overuse headache (MOH) increases successful withdrawal, and to study determinants of response to withdrawal therapy. Methods A retrospective, controlled follow-up study was performed with 416 MOH patients. All patients were treated with outpatient withdrawal therapy, with two treatment arms: with or without the support of a specialised hea...περισσότερα »
Toward a pragmatic migraine model for drug testing: 1. Cilostazol in healthy volunteers
Toward a pragmatic migraine model for drug testing: 1. Cilostazol in healthy volunteers: Background A model for the testing of novel antimigraine drugs should ideally use healthy volunteers for ease of recruiting. Cilostazol provokes headache in healthy volunteers with some migraine features such as pulsating pain quality and aggravation by physical activity. Therefore, this headache might respond to sumatriptan, a requirement for validation. The hypothesis of the present study was that sumatriptan but not placebo is effective in cilostazol-induced headache in healthy individuals. ... περισσότερα »
Intracranial abnormalities and headache: A population-based imaging study (HUNT MRI)
Intracranial abnormalities and headache: A population-based imaging study (HUNT MRI): Background Most studies on intracranial abnormalities among headache sufferers were performed in selected clinical populations. The aim of this study was to evaluate the relationship between intracranial abnormalities and headache among middle-aged adults in the general population. Methods Participants in a large epidemiological study (the HUNT 3 study; 2006–2008) who answered a headache questionnaire and participated in a population-based imaging study of the head (HUNT MRI; 2007–2009) were incl... περισσότερα »
Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache
Meningeal transient receptor potential channel M8 activation causes cutaneous facial and hindpaw allodynia in a preclinical rodent model of headache: Background Migraine headache is a neurological disorder affecting millions worldwide. However, little is known about the mechanisms contributing to migraine. Recent genome-wide association studies have found single nucleotide polymorphisms in the gene encoding transient receptor potential channel M8. Transient receptor potential channel M8 is generally known as a cold receptor but it has been implicated in pain signaling and may play a...περισσότερα »
The use of illicit drugs as self-medication in the treatment of cluster headache: Results from an Italian online survey
The use of illicit drugs as self-medication in the treatment of cluster headache: Results from an Italian online survey: Background Cluster headache (CH) patients often receive unsatisfactory treatment and may explore illicit substances as alternatives. We aimed to explore this use of illicit drugs for CH treatment. Methods We invited CH patients from an Internet-based self-help group to complete a questionnaire regarding their therapeutic use of illicit substances. Results Of the 54 respondents, 29 were classified as chronic and 39 were drug-resistant cases. Fifty patients had pr... περισσότερα »
Adult-onset recurrent painful ophthalmoplegic neuropathy displaying atypical oculomotor nerve gadolinium-enhancement pattern in the orbit and cavernous sinus
Adult-onset recurrent painful ophthalmoplegic neuropathy displaying atypical oculomotor nerve gadolinium-enhancement pattern in the orbit and cavernous sinus: Figure 1. 1.5-T magnetic resonance imaging performed one week after the onset of ocular motor symptoms of adult-onset recurrent painful ophthalmoplegic neuropathy. (a) Axial gadolinium enhanced T1-weighted imaging (T1WI) showing slight enhancement at the root exit zone of the right oculomotor nerve. (b) Coronal high-resolution fat-suppressed post-contrast T1WI showing significant enhancement of the right oculomotor nerve at t...περισσότερα »
Improving Spoken Language Outcomes for Children With Hearing Loss: Data-driven Instruction
Improving Spoken Language Outcomes for Children With Hearing Loss: Data-driven Instruction: [image: image]Objective: To assess the effects of data-driven instruction (DDI) on spoken language outcomes of children with cochlear implants and hearing aids. Study Design: Retrospective, matched-pairs comparison of post-treatment speech/language data of children who did and did not receive DDI. Setting: Private, spoken-language preschool for children with hearing loss. Subjects: Eleven matched pairs of children with cochlear implants who attended the same spoken language preschool. Groups wer...περισσότερα »
Cortical Plasticity and Reorganization in Pediatric Single-sided Deafness Pre- and Postcochlear Implantation: A Case Study
Cortical Plasticity and Reorganization in Pediatric Single-sided Deafness Pre- and Postcochlear Implantation: A Case Study: [image: image]Hypothesis: The purpose of this study was to examine changes in cortical development and neuroplasticity in a child with single-sided deafness (SSD) before and after cochlear implantation (CI). Background: The extent to which sensory pathways reorganize in childhood SSD is not well understood and there is currently little evidence demonstrating the efficacy of CI in children with SSD. Methods: High-density 128-channel electroencephalography (EEG) wa... περισσότερα »
Beyond Early Intervention: Supporting Children With CIs Through Elementary School
Beyond Early Intervention: Supporting Children With CIs Through Elementary School: [image: image]Background: The development of cochlear implants (CIs) and the broader availability of early intervention, made possible by newborn hearing screening, have raised prospects that deaf children can be mainstreamed at the start of elementary school and fare well with minimal support. This report examines the veracity of that perspective. Methods: This report specifically: (1) reviews progress made by deaf children in spoken language acquisition over the past 25 years; (2) presents data colle...περισσότερα »
Does Bilateral Experience Lead to Improved Spatial Unmasking of Speech in Children Who Use Bilateral Cochlear Implants?
Does Bilateral Experience Lead to Improved Spatial Unmasking of Speech in Children Who Use Bilateral Cochlear Implants?: [image: image]Hypothesis: In children with bilateral cochlear implants (BiCIs), experience over a 1 to 3-year period can improve speech understanding and spatial unmasking of speech. Background: One reason for providing children with BiCIs is to improve spatial hearing abilities. Little is known about changes in performance with added bilateral experience, and the relation between sound localization and spatial unmasking of speech. Methods: Twenty children with BiC... περισσότερα »
Speech Understanding in Children With Normal Hearing: Sound Field Normative Data for BabyBio, BKB-SIN, and QuickSIN
Speech Understanding in Children With Normal Hearing: Sound Field Normative Data for BabyBio, BKB-SIN, and QuickSIN: [image: image]Objective: The primary goal was to establish normative data for the Pediatric AzBio “BabyBio,” QuickSIN, and BKB-SIN measures in the sound field for children with normal hearing. Setting: Tertiary care hospital; cochlear implant (CI) program. Patients: Forty-one children with normal hearing were recruited across four age groups (5–6, 7–8, 9–10, and 11–12 yr). Interventions: Sentence recognition testing was assessed at four different signal-to-noise ratios ... περισσότερα »
Speech Recognition of Bimodal Cochlear Implant Recipients Using a Wireless Audio Streaming Accessory for the Telephone
Speech Recognition of Bimodal Cochlear Implant Recipients Using a Wireless Audio Streaming Accessory for the Telephone: [image: image]Objective: The goals of the present investigation were (1) to evaluate recognition of recorded speech presented over a mobile telephone for a group of adult bimodal cochlear implant users, and (2) to measure the potential benefits of wireless hearing assistance technology (HAT) for mobile telephone speech recognition using bimodal stimulation (i.e., a cochlear implant in one ear and a hearing aid on the other ear). Study Design: A three-by-two-way repe...περισσότερα »
Language Development in the First Year of Life: What Deaf Children Might Be Missing Before Cochlear Implantation
Language Development in the First Year of Life: What Deaf Children Might Be Missing Before Cochlear Implantation: Objectives: Language development is a multifaceted, dynamic process involving the discovery of complex patterns, and the refinement of native language competencies in the context of communicative interactions. This process is already advanced by the end of the first year of life for hearing children, but prelingually deaf children who initially lack a language model may miss critical experiences during this early window. The purpose of this review is twofold. First, we ex... περισσότερα »
Initial Results With Image-guided Cochlear Implant Programming in Children
Initial Results With Image-guided Cochlear Implant Programming in Children: [image: image]Hypothesis: Image-guided cochlear implant (CI) programming can improve hearing outcomes for pediatric CI recipients. Background: CIs have been highly successful for children with severe-to-profound hearing loss, offering potential for mainstreamed education and auditory-oral communication. Despite this, a significant number of recipients still experience poor speech understanding, language delay, and, even among the best performers, restoration to normal auditory fidelity is rare. Although signi...περισσότερα »
Method of Speech Stimulus Presentation Impacts Pediatric Speech Recognition: Monitored Live Voice Versus Recorded Speech
Method of Speech Stimulus Presentation Impacts Pediatric Speech Recognition: Monitored Live Voice Versus Recorded Speech: [image: image]Objective: To characterize the potential differences in speech understanding performance on word and sentence tests assessed using live voice and recorded speech measures for pediatric cochlear implant (CI) recipients. Study Design: This clinical study used a combination of retrospective and prospective study designs exploring within-subject performance for recorded versus monitored-live-voice presentation methods on pediatric word and sentence measu...περισσότερα »
Sentence Recognition in Quiet and Noise by Pediatric Cochlear Implant Users: Relationships to Spoken Language
Sentence Recognition in Quiet and Noise by Pediatric Cochlear Implant Users: Relationships to Spoken Language: [image: image]Objective: We investigated associations between sentence recognition and spoken language for children with cochlear implants (CI) enrolled in the Childhood Development after Cochlear Implantation (CDaCI) study. Study Design: In a prospective longitudinal study, sentence recognition percent-correct scores and language standard scores were correlated at 48-, 60-, and 72-months post-CI activation. Setting: Six tertiary CI centers in the United States. Patients: Chi...περισσότερα »
Long-term Communication Outcomes for Children Receiving Cochlear Implants Younger Than 12 Months: A Multicenter Study
Long-term Communication Outcomes for Children Receiving Cochlear Implants Younger Than 12 Months: A Multicenter Study: [image: image]Objective: Examine the influence of age at implant on speech perception, language, and speech production outcomes in a large unselected paediatric cohort. Study Design: This study pools available assessment data (collected prospectively and entered into respective databases from 1990 to 2014) from three Australian centers. Patients: Children (n = 403) with congenital bilateral severe to profound hearing loss who received cochlear implants under 6 years o...περισσότερα »
Bilateral Sequential Cochlear Implantation in Patients With Enlarged Vestibular Aqueduct (EVA) Syndrome
Bilateral Sequential Cochlear Implantation in Patients With Enlarged Vestibular Aqueduct (EVA) Syndrome: [image: image]Objectives: To analyze audiometric outcomes after bilateral cochlear implantation in patients with isolated enlarged vestibular aqueduct (EVA) syndrome and associated incomplete partition (IP) malformations. Secondary objective was to analyze rate of cerebrospinal fluid (CSF) gusher in patients with IP-EVA spectrum deformities and compare this with the existing literature. Study Design: Retrospective chart review. Methods: Thirty-two patients with EVA syndrome who rec...περισσότερα »
The Utility of a Predictive Model for Cochlear Implant Operating Time
The Utility of a Predictive Model for Cochlear Implant Operating Time: [image: image] Objective: This study analyzes multiple factors and their significance in determining the operative timing for cochlear implants at one institution over a 10-year period. Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: All patients including both adult and pediatric undergoing cochlear implantation from 2002 through January 2012. Intervention(s): Cochlear implantation. Main Outcome Measure(s): The overall operative room time and surgical duration for patients und... περισσότερα »
Project ASPIRE: Spoken Language Intervention Curriculum for Parents of Low-socioeconomic Status and Their Deaf and Hard-of-Hearing Children
Project ASPIRE: Spoken Language Intervention Curriculum for Parents of Low-socioeconomic Status and Their Deaf and Hard-of-Hearing Children: [image: image]Objective: To investigate the impact of a spoken language intervention curriculum aiming to improve the language environments caregivers of low socioeconomic status (SES) provide for their D/HH children with CI & HA to support children's spoken language development. Study Design: Quasiexperimental. Setting: Tertiary. Patients: Thirty-two caregiver–child dyads of low-SES (as defined by caregiver education ≤ MA/MS and the income proxi... περισσότερα »
Outcomes of Adolescents With a Short Electrode Cochlear Implant With Preserved Residual Hearing
Outcomes of Adolescents With a Short Electrode Cochlear Implant With Preserved Residual Hearing: [image: image]Objective: The purpose of this study was to determine if adolescents with preserved residual low-frequency hearing can develop improved speech perception and maintain localization abilities by combining their acoustic hearing with electrical processing from a short electrode cochlear implant. Study Design: Repeated-measure, single-subject experiment. Setting: Research hospital. Patients: Adolescents with sensorineural hearing loss with a pure-tone average (PTA) between 60 and... περισσότερα »
A Comprehensive Study on the Etiology of Patients Receiving Cochlear Implantation With Special Emphasis on Genetic Epidemiology
A Comprehensive Study on the Etiology of Patients Receiving Cochlear Implantation With Special Emphasis on Genetic Epidemiology: [image: image]Objective: Cochlear implantation is the most important treatment currently available for profound sensorineural hearing loss. The aim of this study was to investigate the etiology of hearing loss in patients with cochlear implantation, and to compare outcomes. Methods: Japanese hearing loss patients who received cochlear implants (CIs) or electric acoustic stimulation (EAS) in Shinshu University hospital (n = 173, prelingual onset: 92, postlin...περισσότερα »
Measuring Success: Cost-Effectiveness and Expanding Access to Cochlear Implantation
Measuring Success: Cost-Effectiveness and Expanding Access to Cochlear Implantation: [image: image]Only a small fraction of patients with profound sensorineural hearing loss have access to cochlear implantation with the majority of these affected people living in developing countries. Cost effectiveness analysis (CEA) is an important tool to demonstrate the value of this technology to healthcare policy makers. This approach requires that hearing healthcare professionals incorporate methods of assessing long-term benefits of cochlear implantation that include psychosocial, quality of ...περισσότερα »
Music Perception of Adolescents Using Electroacoustic Hearing
Music Perception of Adolescents Using Electroacoustic Hearing: [image: image]Background: Preserved residual hearing in adult recipients of short electrode cochlear implants (CIs) contributes to improve perception of speech in noise as well as music. Recently, children and adolescents with sufficient low-frequency hearing but profound loss at higher frequencies enrolled in a FDA trial intended to evaluate the benefit of a short electrode device on the maintenance of residual hearing. This article reports on the perception of several music listening tasks by adolescents using electroa... περισσότερα »
Using the Implant Electrode Array to Conduct Real-time Intraoperative Hearing Monitoring During Pediatric Cochlear Implantation: Preliminary Experiences
Using the Implant Electrode Array to Conduct Real-time Intraoperative Hearing Monitoring During Pediatric Cochlear Implantation: Preliminary Experiences: [image: image]Objectives: To present the preliminary experiences and findings from a pilot study evaluating a novel technique for monitoring cochlear electrophysiological function during electrode insertion in cochlear implantation surgery. Study Design: Prospective pilot cohort study. Setting: Tertiary academic neuro-otology center. Patients: Pediatric patients with residual hearing undergoing hearing preservation cochlear implant s... περισσότερα »
The beneficial effect of Hangesha-shin-to (TJ-014) in gentamicin-induced hair cell loss in the rat cochlea
The beneficial effect of Hangesha-shin-to (TJ-014) in gentamicin-induced hair cell loss in the rat cochlea: Ototoxic damage caused by aminoglycosides (AG) leads to the loss of cochlear hair cells (HCs). In mammals, mature cochlear HCs are unable to regenerate, and their loss results in permanent hearing deficits. Our objective was to protect the inner ear from damage after an AG challenge. The generation of reactive oxygen species (ROS), one of the earliest events in the process of AG ototoxicity, is considered to play a key role in the initiation of HC death. We examined whether Ha... περισσότερα »
Outpatient management of patients with acute tonsillitis and peritonsillar abscess in ninety adult patients
Outpatient management of patients with acute tonsillitis and peritonsillar abscess in ninety adult patients: Abstract Methods Ethical considerations: the protocol used in this evaluation was based upon current best practices and was reviewed and accepted by departmental heads prior to use. A protocol (see Figure 1) was devised based upon the aforementioned current evidence base.3-6 Patients already able to eat and drink prior to treatment were excluded from the protocol; such cases were expected to be managed as outpatients in our Trust. Patients unable to eat and drink were then s... περισσότερα »
Antioxidant diet and sex interact to regulate NOS isoform expression and glomerular mesangium proliferation in Zucker diabetic rat kidney
Publication date: Available online 18 January 2016 *Source:*Acta Histochemica Author(s): Yuriy Slyvka, Ramiro Malgor, Sharon R. Inman, Julia Ding, Victor Heh, Felicia V. Nowak Oxidative stress contributes substantially to the pathophysiology of diabetic nephropathy (DN). Consumption of an antioxidant-fortified (AO) diet from an early age prevents or delays later development of DN in the Zucker rat female with type 2 diabetes. We hypothesize this is due to effects on mesangial matrix and renal nitric oxide synthase (NOS) distribution and to sex-specific differences in NOS responses i... περισσότερα »
Localization of amylin-like immunoreactivity in melanocyte-stimulating hormone-containing cells of the pars intermedia but not those of the pars distalis in the axolotl (Ambystoma mexicanum) pituitary
Publication date: Available online 18 January 2016 *Source:*Acta Histochemica Author(s): Hirohumi Suzuki, Toshiharu Yamamoto Immunohistochemical techniques were employed to investigate the distribution of amylin-like immunoreactivity in the axolotl (Ambystoma mexicanum) pituitary. Amylin-immunoreactive cells were observed in the pars intermedia, and these cells were found to be immunoreactive for α-melanocyte-stimulating hormone (αMSH) as well. In contrast, αMSH-immunoreactive cells in the pars distalis were immuno-negaitive for amylin. These light microscopic findings were confirme...περισσότερα »
Amyotrophic lateral sclerosis: An update on its complexity
from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1SZRTiY via IFTTT
Non-neuronal cells in ALS: Role of glial, immune cells and blood-CNS barriers
ABSTRACT Neurological dysfunction and motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is strongly associated with neuroinflammation reflected by activated microglia and astrocytes in the CNS. In ALS endogenous triggers in the CNS such as aggregated protein and misfolded proteins activate a pathogenic response by innate immune cells. However, there is also strong evidence for a neuroprotective immune response in ALS. Emerging evidence also reveals changes in the peripheral adaptive immune responses as well as alterations in the blood brain barrier that may aid traf...περισσότερα »
Effect of altitude and season on microbial activity, abundance and community structure in Alpine forest soils
In the current context of climate change, the study of microbial communities along altitudinal gradients is especially useful. Only few studies considered altitude and season at the same time. We characterized four forest sites located in the Italian Alps, along an altitude gradient (545-2000 m a.s.l.), to evaluate the effect of altitude in spring and autumn on soil microbial properties. Each site in each season was characterized with regard to soil temperature, physicochemical properties, microbial activities (respiration, enzymes), community-level physiological profiles (CLPP), ... περισσότερα »
Humoral Immune Response Against Human Papillomavirus as Source of Biomarkers for the Prediction and Detection of Cervical Cancer
Viral Immunology , Vol. 0, No. 0. from Allergy\Immunology via ola Kala on Inoreader http://ift.tt/1RQsKs1 via IFTTT
Nocardiopsis mwathae sp. nov., isolated from the haloalkaline Lake Elmenteita in the African Rift Valley
Abstract During a screening for novel and biotechnologically useful bacteria in haloalkaline lakes, strain No.156T was isolated from a sediment sample from lake Elmenteita in the African Rift Valley and studied by a polyphasic taxonomic approach. The strain was observed to form yellow aerial and substrate mycelia; optimal growth was found to be at 30–35… Continue reading Nocardiopsis mwathae sp. nov., isolated from the haloalkaline Lake Elmenteita in the African Rift Valley
Colorectal clinical trials: what is on the horizon?
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lpvi1N via IFTTT
Putative role of SUMOylation in controlling the activity of deubiquitinating enzymes in cancer
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lpvi1B via IFTTT
Immunotherapy with checkpoint inhibitors for lung cancer: novel agents, biomarkers and paradigms
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lpvjCO via IFTTT
National Cancer Center Singapore: the way forward
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1JekuPB via IFTTT
Tendon-derived stem cells undergo spontaneous tenogenic differentiation
Publication date: Available online 18 January 2016 Source:Experimental Cell Research Author(s): Jia Guo, Kai-ming Chan, Jin-fang Zhang, Gang Li Tendon-derived stem cell (TDSC) is a subpopulation of residing stem cells within the intact tendon tissues, with the capacities of self-renewal, clonogenicity, and three-lineage differentiation. Compared with bone marrow derived mesenchymal stem cells (BMSCs), TDSCs are… Continue reading Tendon-derived stem cells undergo spontaneous tenogenic differentiation
Targeted screening of at-risk adults for acute HIV-1 infection in sub-Saharan Africa
AIDS (London, England) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nh893h via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1T0zvGR via IFTTT
LPS-stimulated inflammation inhibits BMP-9-induced osteoblastic differentiation through crosstalk between BMP/MAPK and Smad signaling
Publication date: Available online 18 January 2016 Source:Experimental Cell Research Author(s): Lu Daigang, Qu Jining, Lei Jinlai, Wang Pengfei, Sun Chuan, Huang Liangku, Tian Ding, Song Zhe, Wei Wei, Li Zhong, Zhang. Kun Inflammation is a common situation during bone healing and is recognized to inhibit osteogenic differentiation and bone formation. However, the effect of… Continue reading LPS-stimulated inflammation inhibits BMP-9-induced osteoblastic differentiation through crosstalk between BMP/MAPK and Smad signaling
High multiplicity HIV-1 cell-to-cell transmission from macrophages to CD4+ T cells limits antiretroviral efficacy
AIDS (London, England) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nh88MQ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ZxRmET via IFTTT
Risk of endocrine complications in cancer patients treated with immune check point inhibitors: a meta-analysis
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1JekvTA via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ZxRkwA via IFTTT
Unknown primary tumors: is there a future therapeutic role for immune checkpoint inhibitors?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 45 δευτερόλεπτα
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lpvhuK via IFTTT
New in vitro models to study amyotrophic lateral sclerosis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 45 δευτερόλεπτα
Abstract Amyotrophic Lateral Sclerosis (ALS) is a complex multifactorial disorder, characterized by motor neuron loss with involvement of several other cell types, including astrocytes, oligodendrocytes and microglia. Studies in vivo and in in vitro models have highlighted that the contribution of non-neuronal cells to the disease is a primary event and ALS pathogenesis is driven […]
Clinical outcomes in octogenarians treated with docetaxel as first-line chemotherapy for castration-resistant prostate cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 45 δευτερόλεπτα
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Jekuz8 via IFTTT
ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer, version 1.1
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 45 δευτερόλεπτα
To the Editor, from Rathiotherapy via ola Kala on Inoreader http://ift.tt/1ZIMsKy via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OtwVG5 via IFTTT
Effective targeting of colorectal cancer cells using TORC1/2 kinase inhibitors in vitro and in vivo
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 45 δευτερόλεπτα
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lpviPn via IFTTT
Levator lengthening technique using cartilage or fascia graft for paralytic lagophthalmos in facial paralysis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 45 δευτερόλεπτα
Lid loading using gold weight has been commonly used for treating paralytic lagophthalmos (PL); however, the procedure has a relatively high complication rate and the availability of these plates varies among social circumstances. We used a levator lengthening (LL) technique, which originally elongated the levator aponeurosis by inserting a fascia graft between the edge of […]
The calm before the storm: a report from the International Liver Cancer Association Congress 2015 – part 2
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 45 δευτερόλεπτα
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lpvgXB via IFTTT
Prevalence and factors associated with persistent pain following body contouring surgery
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 45 δευτερόλεπτα
Persistent postsurgical pain has been reported by patients following various surgeries. Body contouring procedures are being performed more frequently, but no data are available regarding the effects of these procedures. Long-term disability occuring after «functional» procedures performed on healthy subjects is a particular concern. The aim of this study was to describe the risk factors, […]
The calm before the storm: a report from the International Liver Cancer Association congress 2015 – part 1
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 45 δευτερόλεπτα
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lpvgH4 via IFTTT
Digital Evaluation of Orbital Development after Self-inflating Hydrogel Expansion in Chinese Children with Congenital Microphthalmia
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 45 δευτερόλεπτα
Assessment of the growth of bony orbit in children with blind microphthalmia is essential to the management. In this study variables were measured to evaluate the development of the bony microphthalmic orbits after treated with self-inflating hydrogel expanders. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1PCqYUW via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros […]
Use of pentoxifylline and tocopherol in the management of osteoradionecrosis
Osteoradionecrosis (ORN) is a complication of radiotherapy, and is difficult to manage once established. However, its pathogenesis has been reinvestigated, and it is now thought to be potentially amenable to treatment with pentoxifylline and tocopherol (vitamin E). We made a retrospective analysis of 62 patients with established ORN who were treated in this way. When only pentoxifylline and vitamin E was used ORN resolved in 14/25 (56%) but paradoxically, when it was combined with antibiotics, only 6/22 resolved (27%). from OroFacial Medicine via ola Kala on Inoreader http://ift.t... περισσότερα »
Accidental intraoral injection of formalin during extraction: case report
Transparent, clear solutions such as hydrogen peroxide, alcohol, sodium hypochlorite, formaldehyde, and local anaesthetics are widely used in dentistry, so the tissues are liable to accidental injury. Formalin, a 37%-40% solution of formaldehyde, is extensively used in 10% solution as a tissue preservative, but it has toxic effects on systems such as the gastrointestinal tract, respiratory tract, skin, and mucosa. However, we know of few reports of cases of inadvertent injection of alcohol and formalin directly into the human body. from OroFacial Medicine via ola Kala on Inoreader... περισσότερα »
New in vitro models to study amyotrophic lateral sclerosis
Abstract Amyotrophic Lateral Sclerosis (ALS) is a complex multifactorial disorder, characterized by motor neuron loss with involvement of several other cell types, including astrocytes, oligodendrocytes and microglia. Studies *in vivo* and in *in vitro* models have highlighted that the contribution of non-neuronal cells to the disease is a primary event and ALS pathogenesis is driven by both cell-autonomous and non-cell autonomous mechanisms. The advancements in genetics and *in vitro* modeling of the past 10 years have dramatically changed the way we investigate the pathogenic me... περισσότερα »
ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer, version 1.1
To the Editor, from Rathiotherapy via ola Kala on Inoreader http://ift.tt/1ZIMsKy via IFTTT
Digital Evaluation of Orbital Development after Self-inflating Hydrogel Expansion in Chinese Children with Congenital Microphthalmia
Assessment of the growth of bony orbit in children with blind microphthalmia is essential to the management. In this study variables were measured to evaluate the development of the bony microphthalmic orbits after treated with self-inflating hydrogel expanders. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1PCqYUW via IFTTT
A Simplified Method for Correcting Tanzer’s Group II Constricted Ears: Construction of the Superior Crus As a Strut with Cartilage Expansion Grafting
A constricted ear, also known as a cup ear or lop ear, is a deformity characterized by curling of the upper portion of the ear, including the helix, scapha, and antihelix. In Tanzer's classification, group II constricted ears have deformities involving the helix and the scapha. Although partial or total absence of the superior crus of the antihelix has been noted in group II constricted ears, most plastic surgeons have corrected group II constricted ears using the expansion technique and skin flaps, without formation of the superior crus. from #Aesthetics via alexandrossfakianakis... περισσότερα »
The Medial Sural Artery Perforator Flap in Intra-Oral Reconstruction: A North East Experience
The medial sural artery perforator (MSAP) flap is a fasciocutaneous flap that is gaining popularity for intra-oral reconstructions. The aim of this two-centre review was to evaluate the use of the MSAP flap in intra-oral reconstructions and report our experiences. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1ZIIly5 via IFTTT
Gorlin syndrome with an ovarian leiomyoma associated with a PTCH1 second hit
We describe a Gorlin syndrome (GS) case with two different second hit mutations of *PTCH1*, one in a keratocystic odontogenic tumor (KCOT) and the other in an ovarian leiomyoma. GS is a rare genetic condition manifesting as multiple basal cell nevi associated with other features such as medulloblastomas, skeletal abnormalities, and ovarian fibromas. A 21-year-old Japanese woman with a history of two KCOTs was diagnosed with GS according to clinical criteria. A *PTCH1* mutation, c.1427del T, was detected in peripheral blood. A novel *PTCH1* mutation, c.264_265insAATA, had been fou...περισσότερα »
Detailed analysis of 26 cases of 1q partial duplication/triplication syndrome
Partial 1q trisomy syndrome is a rare disorder. Because unbalanced chromosomal translocations often occur with 1q trisomy, it is difficult to determine whether patient symptoms are related to 1q trisomy or other chromosomal abnormalities. The present study evaluated genotype–phenotype correlations of 26 cases diagnosed with 1q partial trisomy syndrome. DNA microarray was used to investigate the duplication/triplication region of 16 cases. Although there was no overlapping region common to all 26 cases, the 1q41-qter region was frequently involved. One case diagnosed as a pure int...περισσότερα »
Gene-Based Association Analysis for Censored Traits Via Fixed Effect Functional Regressions
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
ABSTRACT Genetic studies of survival outcomes have been proposed and conducted recently, but statistical methods for identifying genetic variants that affect disease progression are rarely developed. Motivated by our ongoing real studies, here we develop Cox proportional hazard models using functional regression (FR) to perform gene-based association analysis of survival traits while adjusting for covariates. […]
The Role of MRI and CT in the Diagnosis of Atherosclerosis in an Aging Population
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Atherosclerosis and its related complications represent a major cause of morbidity and mortality worldwide. Morbidity and mortality rates for cardiovascular disease actually increase with age, which is an issue considering the growing geriatric population. In recent years, non-invasive diagnostic imaging—mainly CT and MRI—has seen an increasingly important role in diagnosing atherosclerosis early, improving risk […]
Outpatient management of patients with acute tonsillitis and peritonsillar abscess in ninety adult patients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Methods Ethical considerations: the protocol used in this evaluation was based upon current best practices and was reviewed and accepted by departmental heads prior to use. A protocol (see Figure 1) was devised based upon the aforementioned current evidence base.3-6 Patients already able to eat and drink prior to treatment were excluded from the […]
Crystal Structure of Manganese Lipoxygenase of the Rice Blast Fungus Magnaporthe oryzae Enzymology
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Lipoxygenases (LOX) are non-heme metal enzymes, which oxidize polyunsaturated fatty acids to hydroperoxides. All LOX belong to the same gene family, and they are widely distributed. LOX of animals, plants and prokaryotes contain Fe as the catalytic metal, whereas fungi express LOX with Fe or with Mn. Little is known about metal selection by LOX […]
The Role of MRI and CT in the Diagnosis of Atherosclerosis in an Aging Population
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Atherosclerosis and its related complications represent a major cause of morbidity and mortality worldwide. Morbidity and mortality rates for cardiovascular disease actually increase with age, which is an issue considering the growing geriatric population. In recent years, non-invasive diagnostic imaging—mainly CT and MRI—has seen an increasingly important role in diagnosing atherosclerosis early, improving risk […]
Impaired quality of life in adults with X-linked hypophosphatemia and skeletal symptoms
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objective Adults with X-linked hypophosphatemia (XLH) may suffer from skeletal symptoms leading to functional disability. No data on their quality of life (QoL) have been reported so far. Our objectives were to evaluate the QoL and its determinants in XLH adults. Patients and methods We conducted a prospective study in XLH adults, who consulted for […]
Special Safety Anesthetic Requirements for Pediatric Patients in the MR Environment
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract In this article, we review recent updates in special safety considerations for the anesthetic management of pediatric patients in the MR environment. We discuss the inherent risks and hazards of the MR environment itself and necessary safety precautions. We evaluate the patient risk factors that may impact a safe sedation or anesthesia. We present […]
Chronic stress and oral cancer research: Disregarded aspects in animal model studies
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Xie et al. illustrated the effects of chronic physical stress on an animal model. The authors demonstrated that stress-related mediators (catecholamine and glucocorticoid) can enhance the production of angiogenic cytokines VEGF and MMP-2 [1]. We would like to take this opportunity to discuss some of the issues associated with oral cancer research and stress in […]
Crystal Structure of Manganese Lipoxygenase of the Rice Blast Fungus Magnaporthe oryzae Enzymology
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Lipoxygenases (LOX) are non-heme metal enzymes, which oxidize polyunsaturated fatty acids to hydroperoxides. All LOX belong to the same gene family, and they are widely distributed. LOX of animals, plants and prokaryotes contain Fe as the catalytic metal, whereas fungi express LOX with Fe or with Mn. Little is known about metal selection by LOX […]
Is p16-positive oropharyngeal squamous cell carcinoma associated with favorable prognosis? A systematic review and meta-analysis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Squamous cell cancers of the head and neck as a group represent the sixth most common malignancy worldwide [1]. While the overall incidence of head and neck cancers (HNC) at various anatomic subsites such as the ventrolateral tongue and floor of mouth has decreased in conjunction with reduced smoking and drinking rates, oropharyngeal squamous cell […]
Generalization of Rare Variant Association Tests for Longitudinal Family Studies
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ABSTRACT Given the functional relevance of many rare variants, their identification is frequently critical for dissecting disease etiology. Functional variants are likely to be aggregated in family studies enriched with affected members, and this aggregation increases the statistical power to detect rare variants associated with a trait of interest. Longitudinal family studies provide additional information […]
Sequence Kernel Association Test of Multiple Continuous Phenotypes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ABSTRACT Genetic studies often collect multiple correlated traits, which could be analyzed jointly to increase power by aggregating multiple weak effects and provide additional insights into the etiology of complex human diseases. Existing methods for multiple trait association tests have primarily focused on common variants. There is a surprising dearth of published methods for testing […]
Gene-Based Association Analysis for Censored Traits Via Fixed Effect Functional Regressions
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ABSTRACT Genetic studies of survival outcomes have been proposed and conducted recently, but statistical methods for identifying genetic variants that affect disease progression are rarely developed. Motivated by our ongoing real studies, here we develop Cox proportional hazard models using functional regression (FR) to perform gene-based association analysis of survival traits while adjusting for covariates. […]
Outpatient management of patients with acute tonsillitis and peritonsillar abscess in ninety adult patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Methods Ethical considerations: the protocol used in this evaluation was based upon current best practices and was reviewed and accepted by departmental heads prior to use. A protocol (see Figure 1) was devised based upon the aforementioned current evidence base.3-6 Patients already able to eat and drink prior to treatment were excluded from the […]
Special Safety Anesthetic Requirements for Pediatric Patients in the MR Environment
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract In this article, we review recent updates in special safety considerations for the anesthetic management of pediatric patients in the MR environment. We discuss the inherent risks and hazards of the MR environment itself and necessary safety precautions. We evaluate the patient risk factors that may impact a safe sedation or anesthesia. We present […]
The Role of MRI and CT in the Diagnosis of Atherosclerosis in an Aging Population
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Atherosclerosis and its related complications represent a major cause of morbidity and mortality worldwide. Morbidity and mortality rates for cardiovascular disease actually increase with age, which is an issue considering the growing geriatric population. In recent years, non-invasive diagnostic imaging—mainly CT and MRI—has seen an increasingly important role in diagnosing atherosclerosis early, improving risk […]
Crystal Structure of Manganese Lipoxygenase of the Rice Blast Fungus Magnaporthe oryzae Enzymology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Lipoxygenases (LOX) are non-heme metal enzymes, which oxidize polyunsaturated fatty acids to hydroperoxides. All LOX belong to the same gene family, and they are widely distributed. LOX of animals, plants and prokaryotes contain Fe as the catalytic metal, whereas fungi express LOX with Fe or with Mn. Little is known about metal selection by LOX […]
Impaired quality of life in adults with X-linked hypophosphatemia and skeletal symptoms
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective Adults with X-linked hypophosphatemia (XLH) may suffer from skeletal symptoms leading to functional disability. No data on their quality of life (QoL) have been reported so far. Our objectives were to evaluate the QoL and its determinants in XLH adults. Patients and methods We conducted a prospective study in XLH adults, who consulted for […]
Chronic stress and oral cancer research: Disregarded aspects in animal model studies
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Xie et al. illustrated the effects of chronic physical stress on an animal model. The authors demonstrated that stress-related mediators (catecholamine and glucocorticoid) can enhance the production of angiogenic cytokines VEGF and MMP-2 [1]. We would like to take this opportunity to discuss some of the issues associated with oral cancer research and stress in […]
Is p16-positive oropharyngeal squamous cell carcinoma associated with favorable prognosis? A systematic review and meta-analysis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Squamous cell cancers of the head and neck as a group represent the sixth most common malignancy worldwide [1]. While the overall incidence of head and neck cancers (HNC) at various anatomic subsites such as the ventrolateral tongue and floor of mouth has decreased in conjunction with reduced smoking and drinking rates, oropharyngeal squamous cell […]
Mitteilungen der Deutschen Gesellschaft für Pathologie
from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1OtobzP via IFTTT
Dermpath Quiz: Which alopecia does the patient have?
*Silvija Pejkovska Gottesman, Khanh Thieu, Dennis Polley, Dirk Elston* Indian Dermatology Online Journal 2016 7(1):53-54 from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1Qan9ZT via IFTTT
Adult-onset familial palmoplantar keratoderma: An uncommon presentation
*Tarang Goyal, Anupam Varshney* Indian Dermatology Online Journal 2016 7(1):66-66 from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1SsR8zH via IFTTT
Scholarships, grants, and training opportunities for dermatology residents in India by Indian Association of Dermatologists, Venereologists and Leprologists
*Venkataram Mysore* Indian Dermatology Online Journal 2016 7(1):3-5 from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1Qan88u via IFTTT
More angioedema from instant coffee, but not from caffeine
*Toban Dvoretzky* Indian Dermatology Online Journal 2016 7(1):60-60 from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1SsR5UG via IFTTT
Position statement for the use of omalizumab in the management of chronic spontaneous urticaria in Indian patients
*Kiran Godse, Murlidhar Rajagopalan, Mukesh Girdhar, Sanjiv Kandhari, Bela Shah, Prashant N Chhajed, Sushil Tahiliani, DS Krupa Shankar, Vijay Somani, Vijay Zawar* Indian Dermatology Online Journal 2016 7(1):6-11 Chronic spontaneous urticaria (CSU) affects 1% of the world population and also their quality of life, and 50% of these patients are refractory to H1-antihistamines. Omalizumab is a humanized monoclonal anti-IgE antibody that binds with free IgE antibodies and reduces the circulating levels of free IgE. This reduction in free IgE prevents mast-cell degranulation. The EAACI...περισσότερα »
Greetings from the desk of Editor-in-Chief
*Sunil Dogra* Indian Dermatology Online Journal 2016 7(1):1-2 from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1SsR5Uu via IFTTT
Photopatch and UV-irradiated patch testing in photosensitive dermatitis
*Reena Rai, Maria Thomas* Indian Dermatology Online Journal 2016 7(1):12-16 Background: The photopatch test is used to detect photoallergic reactions to various antigens such as sunscreens and drugs. Photosensitive dermatitis can be caused due to antigens like parthenium, fragrances, rubbers and metals. The photopatch test does not contain these antigens. Therefore, the Indian Standard Series (ISS) along with the Standard photopatch series from Chemotechnique Diagnostics, Sweden was used to detect light induced antigens. Aim: To detect light induced antigens in patients with photos...περισσότερα »
A cluster randomised controlled trial of advice, exercise or multifactorial assessment to prevent falls and fractures in community-dwelling older adults: protocol for the prevention of falls injury trial (PreFIT)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Introduction Falls are the leading cause of accident-related mortality in older adults. Injurious falls are associated with functional decline, disability, healthcare utilisation and significant National Health Service (NHS)-related costs. The evidence base for multifactorial or exercise interventions reducing fractures in the general population is weak. This protocol describes a large-scale UK trial investigating the clinical […]
Accuracy of non-invasive prenatal testing using cell-free DNA for detection of Down, Edwards and Patau syndromes: a systematic review and meta-analysis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Objective To measure test accuracy of non-invasive prenatal testing (NIPT) for Down, Edwards and Patau syndromes using cell-free fetal DNA and identify factors affecting accuracy. Design Systematic review and meta-analysis of published studies. Data sources PubMed, Ovid Medline, Ovid Embase and the Cochrane Library published from 1997 to 9 February 2015, followed by weekly autoalerts […]
Role of Helicobacter pylori and interleukin 6 -174 gene polymorphism in dyslipidemia: a case-control study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Objective To assess the role of Helicobacter pylori infection and interleukin 6 polymorphism -174 (rs1800795) in dyslipidemia. Design Case–control study comparing serum lipids between H. pylori positive and negative patients and controlling for IL-6 -174 polymorphism, age, sex and smoking. Setting 3 hospitals performing outpatient endoscopies in the city of Oulu, Finland. Participants 199 adult […]
Correction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Giacco D, Bird VJ, McCrone P, et al. Specialised teams or personal continuity across inpatient and outpatient mental healthcare? Study protocol for a natural experiment. BMJ Open 2015;5:e008996. Numbers in figure 3 of this article do not match with the text («Sample size determination», page 6). The corrected figure is below. Figure 3 COFI recruitment […]
Caught between intending and doing: older people ideating on a self-chosen death
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Objectives The aim of this paper is to provide insight into what it means to live with the intention to end life at a self-chosen moment from an insider perspective. Setting Participants who lived independent or semidependent throughout the Netherlands. Participants 25 Dutch older citizens (mean age of 82 years) participated. They were ideating on […]
Meta-analysis of the Efficacy and Safety of Secukinumab for the Treatment of Plaque Psoriasis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Background: In January 2015, US FDA approved secukinumab, a human interleukin-17A (IL-17A) antagonist, for the treatment of plaque psoriasis. Objective: To provide unbiased drug information about the efficacy and safety of secukinumab for the treatment of moderate to severe plaque psoriasis by performing meta-analysis. Methods: PubMed and EMBASE database searches were conducted. Among the literatures […]
