Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Δευτέρα 18 Ιανουαρίου 2016

OtoRhinoLaryngology & Medicine,New Articles,January 18th,2016,a


A prognostic model predicts the risk of distant metastasis and death for patients with nasopharyngeal carcinoma based on pre-treatment interleukin 6 and clinical stage

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 λεπτό
A prognostic model predicts the risk of distant metastasis and death for patients with nasopharyngeal carcinoma based on pre-treatment interleukin 6 and clinical stage via Clinical Immunology Publication date: Available online 15 January 2016 *Source:*Clinical Immunology Author(s): Liangru Ke, Yanqun Xiang, Weixiong Xia, Jing Yang, Yahui Yu, Yanfang Ye, Hu Liang, Xiang Guo, Xing Lv Because inflammation plays a critical role in nasopharyngeal carcinoma (NPC), this study aims to investigate the correlation between the pro-inflammation cytokine interleukin-6 (IL6) and the prognosis of NPC...περισσότερα »

The Cloning and Expression of Human Monoclonal Antibodies: Implications for Allergen Immunotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 λεπτό
The Cloning and Expression of Human Monoclonal Antibodies: Implications for Allergen Immunotherapy: AbstractAllergic responses are dependent on the highly specific effector functions of IgE antibodies. Conversely, antibodies that block the activity of IgE can mediate tolerance to allergen. Technologies that harness the unparalleled specificity of antibody responses have revolutionized the way that we diagnose and treat human disease. This area of research continues to advance at a rapid pace and has had a significant impact on our understanding of allergic disease. This review will...περισσότερα »

The Cloning and Expression of Human Monoclonal Antibodies: Implications for Allergen Immunotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
The Cloning and Expression of Human Monoclonal Antibodies: Implications for Allergen Immunotherapy: AbstractAllergic responses are dependent on the highly specific effector functions of IgE antibodies. Conversely, antibodies that block the activity of IgE can mediate tolerance to allergen. Technologies that harness the unparalleled specificity of antibody responses have revolutionized the way that we diagnose and treat human disease. This area of research continues to advance at a rapid pace and has had a significant impact on our understanding of allergic disease. This review will...περισσότερα »

Perfusion of the diep flaps: A systematic review with meta-analysis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
Perfusion of the diep flaps: A systematic review with meta-analysis: Purpose Perfusion zones of the deep inferior epigastric perforator (DIEP) flap aid surgeons in estimating approximate tissue territory with reliable perfusion. Since the Hartrampf perfusion zone was developed, it has been modified continuously; however controversies remain regarding whether the recent perfusion models can satisfy current anatomical and clinical evidence. We conducted a comprehensive review of previous studies to synthesize relevant knowledge and critically reappraise current perfusion models. Meth... περισσότερα »

The effect of different application timings of hyperbaric oxygen treatment on nerve regeneration in rats

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
The effect of different application timings of hyperbaric oxygen treatment on nerve regeneration in rats: Background The aim of the study was to determine the effect of different application timings of hyperbaric oxygen treatment (HBO) on nerve regeneration in rats. Materials and Methods A total of forty 12-week-old female Wistar albino rats were used. The sciatic nerve was transected. The nerve ends were then realigned and repaired using standard microsurgical techniques. Animals were randomly assigned to four groups: 1) No hyperbaric oxygen, sectioned and repaired; 2) HBO started ... περισσότερα »

Retrospective study on factors affecting the prognosis in oral cancer patients who underwent surgical treatment only

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
Retrospective study on factors affecting the prognosis in oral cancer patients who underwent surgical treatment only: Abstract BackgroundThis study was performed to evaluate their 5-year survival rates and identify the factors affecting the prognosis of oral cancer patients who had undergone surgical treatment only. MethodsAmong 130 patients who were diagnosed with malignant tumor of oral, maxillofacial, and surgical treated in the Department of Oral and Maxillofacial Surgery at Chonnam National University Hospital within a period from January 2000 to December 2010, for 11 year...περισσότερα »

A Practical Surgical Technique to Expose the Mental Nerve in Narrowing Genioplasty

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
A Practical Surgical Technique to Expose the Mental Nerve in Narrowing Genioplasty: [image: image]Summary: In this article, the authors present a practical surgical technique using the anatomical character of the inferior alveolar nerve to fully expose the mental nerve (MN) in narrowing genioplasty. During the procedure, a rectangular mandibular outer cortex adjacent to the mental foramen is removed before the osteotomy. The objective is to avoid the injury of the MN from the reciprocating saw or bur and offer abundant space for the surgical operation. The technique has a minimal le... περισσότερα »

Total Columella Reconstruction Using Nasocheek Flap and Septal Cartilage Graft

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
Total Columella Reconstruction Using Nasocheek Flap and Septal Cartilage Graft: [image: image]Summary: The use of the nasocheek sulcus flap with a cartilage strut provides an aesthetically pleasing result in total columella reconstruction. This provides thin hairless skin appropriate for the subunit. Mohs surgery aids in limiting the excision to the tumor involved area, providing a complete clearance and conserving precious units, which have an impact on the reconstructive options. The method of reconstruction described here is simple and easily reproducible, providing an optimal re... περισσότερα »

Denying the Obvious: Four Extreme Cases of Neglected Tumors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
Denying the Obvious: Four Extreme Cases of Neglected Tumors: [image: image] Background: Little is known about the relatively common phenomenon of patients neglecting tumors as part of a denial mechanism to presumably cope with the obvious, outward and clearly visible signs of cancer. As a result of this tumor neglect, disease progression continues unchecked, resulting in excessive tumor growth, invasion of nearby structures, (often) metastatic spread, and significant disfigurement. Methods: In this case series, we present 4 extreme cases of neglected tumors that posed significant re...περισσότερα »

LED Light Characteristics for Surgical Shadowless Lamps and Surgical Loupes

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
LED Light Characteristics for Surgical Shadowless Lamps and Surgical Loupes: [image: image]Background: Blue light has more energy than longer wavelength light and can penetrate the eye to reach the retina. When surgeons use magnifying loupes under intensive surgical shadowless lamps for better view of the surgical field, the total luminance is about 200 times brighter than that of typical office lighting. In this study, the effects of 2 types of shadowless lamps were compared. Moreover, the effect of various eyeglasses, which support magnifying loupes, on both the light energy and co... περισσότερα »

The Role of Muscle Flaps for Salvage of Failed Perforator Free Flaps

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
The Role of Muscle Flaps for Salvage of Failed Perforator Free Flaps: [image: image]Background: Despite the most heroic efforts, sometimes free flaps fail. Perforator free flaps are not invincible and can suffer the same fate. The real challenge is how to decide what is the next best choice for achieving the desired outcome. Methods: Over the past decade, 298 free perforator flaps were used in our institution. Total failure occurred in 16 patients, and partial failure requiring a second free flap occurred in an additional 6 patients for a true success rate of 93%. All failures had so... περισσότερα »

Reconstruction of Chopart’s Amputation Stump Using Artificial Dermis Combined with Free Anterolateral Thigh Flap

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
Reconstruction of Chopart’s Amputation Stump Using Artificial Dermis Combined with Free Anterolateral Thigh Flap: [image: image]Summary: A 63-year-old man dropped a metal chunk onto his left foot during his work and suffered a crush injury of the left forefoot. He underwent Chopart’s amputation followed by stump coverage with sole skin at the orthopedic department on the same day. He was referred to our department for reconstruction because of poor vascularization and subsequent necrosis of tissue at the stump. After the necrotic tissue was debrided, exposure of the talus bone was n... περισσότερα »

Costal Grafting in Mandibular Reconstruction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
Costal Grafting in Mandibular Reconstruction: [image: image]Background: Reconstruction of mandibular bone defect is a common indication in craniomaxillofacial surgery, and free fibular flap is the gold standard for this indication. However, there are alternatives; nonvascular bone grafting is one of them, and we present the costal grafting for mandibular reconstruction, a classic technique that is reliable, efficient, and produced less morbidity than the technique of using composite free flaps. Method: A 9-year retrospective review of 54 patients treated surgically for mandibular rec... περισσότερα »

The Role of Embryologic Fusion Planes in the Invasiveness and Recurrence of Basal Cell Carcinoma: A Classic Mix-Up of Causation and Correlation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
The Role of Embryologic Fusion Planes in the Invasiveness and Recurrence of Basal Cell Carcinoma: A Classic Mix-Up of Causation and Correlation: [image: image]Background: The facial embryologic fusion planes as regions of mesenchymal and ectodermal fusion of the primordial facial processes during embryological development have been suggested to influence the spread, invasiveness, pathogenesis, and recurrence of cutaneous carcinoma. This study sought to establish whether basal cell carcinoma (BCC) originating in embryologic fusion planes has a greater propensity for earlier depth of ...περισσότερα »

Mechanobiology and Mechanotherapy of Adipose Tissue-Effect of Mechanical Force on Fat Tissue Engineering

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
Mechanobiology and Mechanotherapy of Adipose Tissue-Effect of Mechanical Force on Fat Tissue Engineering: Summary: Our bodies are subjected to various mechanical forces, which in turn affect both the structure and function of our bodies. In particular, these mechanical forces play an important role in tissue growth and regeneration. Adipocytes and adipose-derived stem cells are both mechanosensitive and mechanoresponsive. The aim of this review is to summarize the relationship between mechanobiology and adipogenesis. PubMed was used to search for articles using the following keyword... περισσότερα »

Hodgkin and Reed–Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylati on

In this study, we have compared metabolic features of Hodgkin–Reed–Sternberg (HRS) cells, the tumor cells of classical Hodgkin’s lymphoma (cHL), one of the most frequent (post‐)GC‐derived B‐cell lymphomas, with their normal GC B cell counterparts. We found that the ratio of oxidative to nonoxidative energy conversion was clearly shifted toward oxidative phosphorylation (OXPHOS)‐linked ATP synthesis […]

A functional variant in TP63 at 3q28 associated with bladder cancer risk by creating an miR‐140‐5p binding site

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Q99B0P via IFTTT

Tonsillectomy can improve quality of life

Adults suffering from frequent sore throats might find relief by having their tonsils removed: after undergoing tonsillectomy (surgical removal of the tonsils), people were found to have fewer… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ne1arY via IFTTT

Predictive Validity of the Youth Level of Service/Case Management Inventory with Youth who have Committed Sexual and Non-Sexual Offenses: The Utility of Professional Override

The predictive validity of the Youth Level of Service/Case Management Inventory (YLS/CMI) and the use of professional override were examined in a matched sample of youth who committed sexual (n = 204) and non-sexual (n = 185) offenses. Based on the actuarial score, the YLS/CMI obtained moderate to strong levels of predictive validity for non-violent, […]

Application of the HCR-20 Version 3 in Civil Psychiatric Patients

This study provides both a structural analysis of the Historical-Clinical-Risk Management–20 (HCR-20) Version 3 and an examination of the correspondence between the HCR-20 Versions 2 and 3. HCR-20 Versions 2 and 3 risk ratings were completed for 64 psychiatric inpatients. Moderate to good interrater reliability was observed for the Version 3 subscales and summary risk […]

A novel HLA‐B allele, HLA‐B*35:254, identified by sequence‐based typing from a HIV‐associated tuberculosis sufferer

HLA‐B*35:254 differs from HLA‐B35:25 by two coding changes at nucleotides positions 142 (T > G) and 292 (T > G). (Source: Tissue Antigens) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NfVtOI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Parenting stress related to raising infants receiving treatment for retinoblastoma

(Source: Psycho-Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RZWQaJ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

How doctors communicate the initial diagnosis of cancer matters: cancer disclosure and its relationship with Patients’ hope and trust

ConclusionsWhen communicating with a cancer patient, doctors might not ignore the importance of emotional support during cancer diagnosis communication. Doctors might want to involve family and collaborate with family to find out ways of personalized disclosure. During the communication process, doctors could provide their patients with multiple treatment options and discuss the benefits and side […]

A systematic review and meta‐analysis of prescribing practices of antidepressants in cancer patients

ConclusionsThere is considerable variation in the prescribing patterns of antidepressants across the world, with few studies reporting robust data on exact dose or follow‐up regimens. Prospective studies that monitor antidepressant prescribing, including details of reasons for prescribing and the healthcare providers involved, dose, change in dose or type of medication and follow‐up are needed to […]

Acute empathy decline among resident physician trainees on a hematology–oncology ward: an exploratory analysis of house staff empathy, distress, and patient death exposure

ConclusionThis study suggests that an acute drop in empathy can occur over several weeks in residents rotating through inpatient hematology–oncology, similar to empathy decline associated with years of training in other studies. Empathy decline may be associated with elevated distress and death exposures on the hematology–oncology ward and should be explored further in other medical […]

Tooth loss and obstructive sleep apnea signs and symptoms

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Tooth loss and obstructive sleep apnea signs and symptoms in the US population: Abstract PurposeThe aim of this study is to investigate the relationship between tooth loss and signs and symptoms of obstructive sleep apnea (OSA) in a representative sample of the general US population. MethodsData were from 7305 men and women aged ≥25 years participating in the 2005–2008 National Health and Nutrition Examination Survey. Tooth loss, occlusal contacts, and denture use were determined by dental examination. Four cardinal OSA signs and symptoms were evaluated by questions based on A... περισσότερα »

Soft tissue stability and volumetric changes after 5 years in pontic sites with or without soft tissue grafting: a retrospective cohort study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Soft tissue stability and volumetric changes after 5 years in pontic sites with or without soft tissue grafting: a retrospective cohort study: Abstract To evaluate volumetric changes (VC) of pontic sites with or without soft tissue grafting over 5 years. Material and Methods Twelve patients participating in a prospective clinical trial evaluating fixed dental prostheses (FDPs) were selected on the basis of having received a subepithelial connective tissue graft for soft volume augmentation in pontic sites (augmentation group [AG]). An additional 12 patients, belonging to the same st... περισσότερα »

Development of Implant Stability Quotient values of implants placed with simultaneous sinus floor elevation – results of a prospective study with 109 implants

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Development of Implant Stability Quotient values of implants placed with simultaneous sinus floor elevation – results of a prospective study with 109 implants: [image: cover.gif?v=1&s=2eb91ab0c0aac4a9489c87d3] Abstract Objectives In patients with implant placement and simultaneous sinus floor elevation (SFE), healing periods of 6 months have been the standard of care for more than 25 years. The primary objective of this prospective case series study was to determine what percentage of implants placed with SFE reach a threshold *Implant Stability Quotient* (ISQ) of ≥70 after 8 we... περισσότερα »

Targeted Intracellular Protein Delivery Based on Hyaluronic Acid-Green Tea Catechin Nanogels

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Targeted Intracellular Protein Delivery Based on Hyaluronic Acid-Green Tea Catechin Nanogels via Acta Biomaterialia Publication date: Available online 16 January 2016 *Source:*Acta Biomaterialia Author(s): Kun Liang, Shengyong Ng, Fan Lee, Jaehong Lim, Joo Eun Chung, Su Seong Lee, Motoichi Kurisawa A novel ternary nanogel based on the self-assembly of hyaluronic acid (HA)-(-)-epigallocatechin gallate (EGCG) conjugates, linear polyethylenimine (PEI) and Granzyme B (GzmB) in aqueous environment was developed for the targeted intracellular delivery of GzmB into cancer cells. Lysozyme-enc... περισσότερα »

Porous resorbable Si-Ca-P-based ceramic with osteoconductive properties

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Bone neoformation of a novel porous resorbable Si-Ca-P-based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study: [image: cover.gif?v=1&s=2eb91ab0c0aac4a9489c87d3] Abstract Objective The aims of the present work were to study a new porous Nurse's A ceramic (Si-Ca-P-based material) bone substitute and examine its mechanical properties *in vitro* and the biocompatibility, osteoconductivity and resorption process *in vivo*. Materials and method Porous ceramic scaffolds were prepared by solid-state reaction and ... περισσότερα »

Cortical Plasticity and Reorganization in Pediatric Single-sided Deafness Pre- and Postcochlear Implantation: A Case Study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Cortical Plasticity and Reorganization in Pediatric Single-sided Deafness Pre- and Postcochlear Implantation: A Case Study: [image: image]Hypothesis: The purpose of this study was to examine changes in cortical development and neuroplasticity in a child with single-sided deafness (SSD) before and after cochlear implantation (CI). Background: The extent to which sensory pathways reorganize in childhood SSD is not well understood and there is currently little evidence demonstrating the efficacy of CI in children with SSD. Methods: High-density 128-channel electroencephalography (EEG) wa... περισσότερα »

Using the Implant Electrode Array to Conduct Real-time Intraoperative Hearing Monitoring During Pediatric Cochlear Implantation: Preliminary Experiences

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Using the Implant Electrode Array to Conduct Real-time Intraoperative Hearing Monitoring During Pediatric Cochlear Implantation: Preliminary Experiences: [image: image]Objectives: To present the preliminary experiences and findings from a pilot study evaluating a novel technique for monitoring cochlear electrophysiological function during electrode insertion in cochlear implantation surgery. Study Design: Prospective pilot cohort study. Setting: Tertiary academic neuro-otology center. Patients: Pediatric patients with residual hearing undergoing hearing preservation cochlear implant s... περισσότερα »

Speech Recognition of Bimodal Cochlear Implant Recipients Using a Wireless Audio Streaming Accessory for the Telephone

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Speech Recognition of Bimodal Cochlear Implant Recipients Using a Wireless Audio Streaming Accessory for the Telephone: [image: image]Objective: The goals of the present investigation were (1) to evaluate recognition of recorded speech presented over a mobile telephone for a group of adult bimodal cochlear implant users, and (2) to measure the potential benefits of wireless hearing assistance technology (HAT) for mobile telephone speech recognition using bimodal stimulation (i.e., a cochlear implant in one ear and a hearing aid on the other ear). Study Design: A three-by-two-way repe...περισσότερα »

Measuring Success: Cost-Effectiveness and Expanding Access to Cochlear Implantation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Measuring Success: Cost-Effectiveness and Expanding Access to Cochlear Implantation: [image: image]Only a small fraction of patients with profound sensorineural hearing loss have access to cochlear implantation with the majority of these affected people living in developing countries. Cost effectiveness analysis (CEA) is an important tool to demonstrate the value of this technology to healthcare policy makers. This approach requires that hearing healthcare professionals incorporate methods of assessing long-term benefits of cochlear implantation that include psychosocial, quality of ...περισσότερα »

Congenital oval or round window malformations in children: Surgical findings and results in 17 cases.

Alexandros G. SfakianakisστοHead and NeckΠριν από 10 δευτερόλεπτα
*Congenital oval or round window malformations in children: Surgical findings and results in 17 cases.* Laryngoscope. 2016 Jan 17; Authors: Vincent R, Wegner I, Derks LS, Grolman W Abstract OBJECTIVES/HYPOTHESIS: To prospectively evaluate surgical findings and hearing results in children undergoing surgery for congenital oval or round window malformations (class IV malformations). STUDY DESIGN: A nonrandomized, nonblinded, case series of prospectively collected data. METHODS: Fourteen consecutive pediatric patients who underwent 17 surgical procedures for congenital oval or round... περισσότερα »

Assessment of pediatric obstructive sleep apnea using a drug-induced sleep endoscopy rating scale.

Alexandros G. SfakianakisστοHead and NeckΠριν από 10 δευτερόλεπτα
*Assessment of pediatric obstructive sleep apnea using a drug-induced sleep endoscopy rating scale.* Laryngoscope. 2016 Jan 17; Authors: Lam DJ, Weaver EM, Macarthur CJ, Milczuk HA, O'Neill E, Smith TL, Nguyen T, Shea SA Abstract OBJECTIVES/HYPOTHESIS: Assess the reliability of a Sleep Endoscopy Rating Scale (SERS) and its relationship with pediatric obstructive sleep apnea (OSA) severity. STUDY DESIGN: Retrospective case series of pediatric patients who underwent drug-induced sleep endoscopy (DISE) at the time of surgery for OSA from January 1, 2013 to May 1, 2014. METHODS: Thr... περισσότερα »

Stem cell approaches for vocal fold regeneration.

Alexandros G. SfakianakisστοHead and NeckΠριν από 10 δευτερόλεπτα
*Stem cell approaches for vocal fold regeneration.* Laryngoscope. 2016 Jan 17; Authors: Fishman JM, Long J, Gugatschka M, De Coppi P, Hirano S, Hertegard S, Thibeault SL, Birchall MA Abstract OBJECTIVES/HYPOTHESIS: Current interventions in the management of vocal fold (VF) dysfunction focus on conservative and surgical approaches. However, the complex structure and precise biomechanical properties of the human VF mean that these strategies have their limitations in clinical practice and in some cases offer inadequate levels of success. Regenerative medicine is an exciting develo...περισσότερα »

Does a multidisciplinary team approach in a tertiary referral centre impact on the initial management of head and neck cancer?

Alexandros G. SfakianakisστοHead and NeckΠριν από 10 δευτερόλεπτα
*Does a multidisciplinary team approach in a tertiary referral centre impact on the initial management of head and neck cancer?* Oral Oncol. 2016 Jan 13; Authors: Bergamini C, Locati L, Bossi P, Granata R, Alfieri S, Resteghini C, Imbimbo M, Fallai C, Orlandi E, Tana S, Iacovelli NA, Guzzo M, Ibba T, Colombo S, Bianchi R, Pizzi N, Fontanella W, Licitra L Abstract OBJECTIVES: A multi-disciplinary team (MDT) is essential in the management of cancer. Head and neck cancer (HNC) is a rare, complex and heterogeneous group of malignancies for which different treatment options are availa... περισσότερα »

Improving Spoken Language Outcomes for Children With Hearing Loss: Data-driven Instruction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Improving Spoken Language Outcomes for Children With Hearing Loss: Data-driven Instruction: [image: image]Objective: To assess the effects of data-driven instruction (DDI) on spoken language outcomes of children with cochlear implants and hearing aids. Study Design: Retrospective, matched-pairs comparison of post-treatment speech/language data of children who did and did not receive DDI. Setting: Private, spoken-language preschool for children with hearing loss. Subjects: Eleven matched pairs of children with cochlear implants who attended the same spoken language preschool. Groups wer...περισσότερα »

Outcomes of Adolescents With a Short Electrode Cochlear Implant With Preserved Residual Hearing

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Outcomes of Adolescents With a Short Electrode Cochlear Implant With Preserved Residual Hearing: [image: image]Objective: The purpose of this study was to determine if adolescents with preserved residual low-frequency hearing can develop improved speech perception and maintain localization abilities by combining their acoustic hearing with electrical processing from a short electrode cochlear implant. Study Design: Repeated-measure, single-subject experiment. Setting: Research hospital. Patients: Adolescents with sensorineural hearing loss with a pure-tone average (PTA) between 60 and... περισσότερα »

The Utility of a Predictive Model for Cochlear Implant Operating Time

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
The Utility of a Predictive Model for Cochlear Implant Operating Time: [image: image] Objective: This study analyzes multiple factors and their significance in determining the operative timing for cochlear implants at one institution over a 10-year period. Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: All patients including both adult and pediatric undergoing cochlear implantation from 2002 through January 2012. Intervention(s): Cochlear implantation. Main Outcome Measure(s): The overall operative room time and surgical duration for patients und... περισσότερα »

Transcanal Micro-Osteotome Only Technique for Excision of Exostoses

Transcanal Micro-Osteotome Only Technique for Excision of Exostoses: Objectives: To evaluate the outcomes and complications of transcanal excision of exostoses using micro-osteotomes, without a postauricular incision or the use of the drill. Study Design: A retrospective chart review of patients undergoing exostoses excision. Setting: Tertiary Care Medical Center. Subjects and Methods: All of the patients […]

Chronic Symptoms After Vestibular Neuritis and the High-Velocity Vestibulo-Ocular Reflex

Chronic Symptoms After Vestibular Neuritis and the High-Velocity Vestibulo-Ocular Reflex: Hypothesis: As the anterior and posterior semicircular canals are vital to the regulation of gaze stability, particularly during locomotion or vehicular travel, we tested whether the high-velocity vestibulo-ocular reflex (VOR) of the three ipsilesional semicircular canals elicited by the modified Head Impulse Test would correlate […]

Music Perception of Adolescents Using Electroacoustic Hearing

Music Perception of Adolescents Using Electroacoustic Hearing: Background: Preserved residual hearing in adult recipients of short electrode cochlear implants (CIs) contributes to improve perception of speech in noise as well as music. Recently, children and adolescents with sufficient low-frequency hearing but profound loss at higher frequencies enrolled in a FDA trial intended to evaluate the […]

Age-related Refixating Saccades in the Three-Dimensional Video-Head-Impulse Test: Source and Dissociation From Unilateral Vestibular Failure

Age-related Refixating Saccades in the Three-Dimensional Video-Head-Impulse Test: Source and Dissociation From Unilateral Vestibular Failure: Objective: To examine “refixating saccades” in the three-dimensional video-head impulse test (vHIT) depending on the age and compare them to refixating saccades in pathological vHIT. Design: Retrospective database study. Setting: County hospital, specialized vertigo center. Patients: Eight hundred ninety-nine patients […]

Project ASPIRE: Spoken Language Intervention Curriculum for Parents of Low-socioeconomic Status and Their Deaf and Hard-of-Hearing Children

Project ASPIRE: Spoken Language Intervention Curriculum for Parents of Low-socioeconomic Status and Their Deaf and Hard-of-Hearing Children: Objective: To investigate the impact of a spoken language intervention curriculum aiming to improve the language environments caregivers of low socioeconomic status (SES) provide for their D/HH children with CI & HA to support children’s spoken language development. […]

Is MRI Equal to CT in the Evaluation of Thin and Dehiscent Superior Semicircular Canals?

Is MRI Equal to CT in the Evaluation of Thin and Dehiscent Superior Semicircular Canals?: Objective: Can magnetic resonance imaging (MRI) diagnose abnormally thin and dehiscent superior semicircular canals (SSCs) that traditionally rely on evaluation by computed tomography (CT) imaging? Study Design: Retrospective clinical study. Setting: Tertiary referral center. Patients: Adults who underwent both MRI […]

Is MRI Equal to CT in the Evaluation of Thin and Dehiscent Superior Semicircular Canals?

Is MRI Equal to CT in the Evaluation of Thin and Dehiscent Superior Semicircular Canals?: Objective: Can magnetic resonance imaging (MRI) diagnose abnormally thin and dehiscent superior semicircular canals (SSCs) that traditionally rely on evaluation by computed tomography (CT) imaging? Study Design: Retrospective clinical study. Setting: Tertiary referral center. Patients: Adults who underwent both MRI […]

Training‐related improvements in musculoskeletal health and balance: a 13‐week pilot study of female cancer survivors

This study examined the feasibility of combined aerobic and resistant training (CART) for improving strength, skeletal health and balance. Cancer survivors (n = 24) were identified by convenience sampling in Los Angeles County with 11 survivors consenting to 13 weeks of CART. Pre‐ and post‐intervention assessments of bone mineral density (BMD), strength, flexibility and biomarker […]

Physical Activity and Survival After Prostate Cancer.

Physical Activity and Survival After Prostate Cancer. Eur Urol. 2016 Jan 7; Authors: Friedenreich CM, Wang Q, Neilson HK, Kopciuk KA, McGregor SE, Courneya KS Abstract BACKGROUND: Despite the high global prevalence of prostate cancer (PCa), few epidemiologic studies have assessed physical activity in relation to PCa survival. OBJECTIVE: To evaluate different types, intensities, and […]

Multimedia information intervention and its benefits in partners of the head and neck cancer patients

We aimed to investigate the levels of anxiety, depression, satisfaction with information provision and cancer‐related knowledge in partners of head and neck cancer (HNC) patients receiving a Multimode Comprehensive Tailored Information Package (MCTIP). A non‐randomised, controlled trial was conducted with partners of HNC patients recruited at two academic hospitals in Montreal. The Test participants received […]

Atrophy of the Stria Vascularis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Atrophy of the Stria Vascularis: [image: image]

Long-term Communication Outcomes for Children Receiving Cochlear Implants Younger Than 12 Months: A Multicenter Study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Long-term Communication Outcomes for Children Receiving Cochlear Implants Younger Than 12 Months: A Multicenter Study: [image: image]Objective: Examine the influence of age at implant on speech perception, language, and speech production outcomes in a large unselected paediatric cohort. Study Design: This study pools available assessment data (collected prospectively and entered into respective databases from 1990 to 2014) from three Australian centers. Patients: Children (n = 403) with congenital bilateral severe to profound hearing loss who received cochlear implants under 6 years o...περισσότερα »

Can High-Resolution Computed Tomography Detect a Therapeutic Response to Medical Treatment in a Patient With Otosclerosis?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Can High-Resolution Computed Tomography Detect a Therapeutic Response to Medical Treatment in a Patient With Otosclerosis?: [image: image]

Method of Speech Stimulus Presentation Impacts Pediatric Speech Recognition: Monitored Live Voice Versus Recorded Speech

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Method of Speech Stimulus Presentation Impacts Pediatric Speech Recognition: Monitored Live Voice Versus Recorded Speech: [image: image]Objective: To characterize the potential differences in speech understanding performance on word and sentence tests assessed using live voice and recorded speech measures for pediatric cochlear implant (CI) recipients. Study Design: This clinical study used a combination of retrospective and prospective study designs exploring within-subject performance for recorded versus monitored-live-voice presentation methods on pediatric word and sentence measu...περισσότερα »

Residual Cholesteatoma After Endoscope-guided Surgery in Children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Residual Cholesteatoma After Endoscope-guided Surgery in Children: [image: image]Objective: Endoscopes can facilitate surgery within tympanomastoid recesses that are not visible with the operating microscope. This study investigates whether use of endoscopes to guide dissection of cholesteatoma leads to lower rates of residual cholesteatoma than using the endoscope only for inspection after microscope-guided dissection. Study Design: Comparative cohort study. Setting: Tertiary pediatric center. Patients: Two hundred thirty-five patients with acquired or congenital cholesteatoma in chi...περισσότερα »

Language Development in the First Year of Life: What Deaf Children Might Be Missing Before Cochlear Implantation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Language Development in the First Year of Life: What Deaf Children Might Be Missing Before Cochlear Implantation: Objectives: Language development is a multifaceted, dynamic process involving the discovery of complex patterns, and the refinement of native language competencies in the context of communicative interactions. This process is already advanced by the end of the first year of life for hearing children, but prelingually deaf children who initially lack a language model may miss critical experiences during this early window. The purpose of this review is twofold. First, we ex... περισσότερα »

Frequency and Demographics of Gentamicin Use

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Frequency and Demographics of Gentamicin Use: [image: image] Objective: To understand how aminoglycosides such as gentamicin are used in a tertiary care setting. To familiarize otologists with the demographics and risk factors associated with gentamicin use at major medical centers to allow the possibility of early intervention. Study Design: Retrospective review of existing clinical data. Setting: University of Rochester Medical Center (URMC), including all associated hospitals (Strong Memorial Hospital, Highland Hospital, etc.). Patients: All hospital inpatients who were prescribed ... περισσότερα »

Beyond Early Intervention: Supporting Children With CIs Through Elementary School

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Beyond Early Intervention: Supporting Children With CIs Through Elementary School: [image: image]Background: The development of cochlear implants (CIs) and the broader availability of early intervention, made possible by newborn hearing screening, have raised prospects that deaf children can be mainstreamed at the start of elementary school and fare well with minimal support. This report examines the veracity of that perspective. Methods: This report specifically: (1) reviews progress made by deaf children in spoken language acquisition over the past 25 years; (2) presents data colle...περισσότερα »

Transcanal Micro-Osteotome Only Technique for Excision of Exostoses

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Transcanal Micro-Osteotome Only Technique for Excision of Exostoses: [image: image]Objectives: To evaluate the outcomes and complications of transcanal excision of exostoses using micro-osteotomes, without a postauricular incision or the use of the drill. Study Design: A retrospective chart review of patients undergoing exostoses excision. Setting: Tertiary Care Medical Center. Subjects and Methods: All of the patients underwent surgical removal of the exostoses using only a 1 or 2 mm micro-osteotomes. Patients were followed postoperatively and associated complications were evaluated....περισσότερα »

Chronic Symptoms After Vestibular Neuritis and the High-Velocity Vestibulo-Ocular Reflex

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Chronic Symptoms After Vestibular Neuritis and the High-Velocity Vestibulo-Ocular Reflex: [image: image]Hypothesis: As the anterior and posterior semicircular canals are vital to the regulation of gaze stability, particularly during locomotion or vehicular travel, we tested whether the high-velocity vestibulo-ocular reflex (VOR) of the three ipsilesional semicircular canals elicited by the modified Head Impulse Test would correlate with subjective dizziness or vertigo scores after vestibular neuritis (VN). Background: Recovery after acute VN varies with around half reporting persist... περισσότερα »

Music Perception of Adolescents Using Electroacoustic Hearing

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Music Perception of Adolescents Using Electroacoustic Hearing: [image: image]Background: Preserved residual hearing in adult recipients of short electrode cochlear implants (CIs) contributes to improve perception of speech in noise as well as music. Recently, children and adolescents with sufficient low-frequency hearing but profound loss at higher frequencies enrolled in a FDA trial intended to evaluate the benefit of a short electrode device on the maintenance of residual hearing. This article reports on the perception of several music listening tasks by adolescents using electroa... περισσότερα »

Age-related Refixating Saccades in the Three-Dimensional Video-Head-Impulse Test: Source and Dissociation From Unilateral Vestibular Failure

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Age-related Refixating Saccades in the Three-Dimensional Video-Head-Impulse Test: Source and Dissociation From Unilateral Vestibular Failure: [image: image]Objective: To examine “refixating saccades” in the three-dimensional video-head impulse test (vHIT) depending on the age and compare them to refixating saccades in pathological vHIT. Design: Retrospective database study. Setting: County hospital, specialized vertigo center. Patients: Eight hundred ninety-nine patients without a peripheral vestibular hypofunction were tested with the three-dimensional vHIT and compared with 135 pati... περισσότερα »

Project ASPIRE: Spoken Language Intervention Curriculum for Parents of Low-socioeconomic Status and Their Deaf and Hard-of-Hearing Children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Project ASPIRE: Spoken Language Intervention Curriculum for Parents of Low-socioeconomic Status and Their Deaf and Hard-of-Hearing Children: [image: image]Objective: To investigate the impact of a spoken language intervention curriculum aiming to improve the language environments caregivers of low socioeconomic status (SES) provide for their D/HH children with CI & HA to support children's spoken language development. Study Design: Quasiexperimental. Setting: Tertiary. Patients: Thirty-two caregiver–child dyads of low-SES (as defined by caregiver education ≤ MA/MS and the income proxi... περισσότερα »

Is MRI Equal to CT in the Evaluation of Thin and Dehiscent Superior Semicircular Canals?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Is MRI Equal to CT in the Evaluation of Thin and Dehiscent Superior Semicircular Canals?: [image: image] Objective: Can magnetic resonance imaging (MRI) diagnose abnormally thin and dehiscent superior semicircular canals (SSCs) that traditionally rely on evaluation by computed tomography (CT) imaging? Study Design: Retrospective clinical study. Setting: Tertiary referral center. Patients: Adults who underwent both MRI and CT of the temporal bones over the past 3 years. Interventions: CT and MR images of SSCs were separately reviewed, in a blinded fashion by three neuroradiologists at...περισσότερα »

Sentence Recognition in Quiet and Noise by Pediatric Cochlear Implant Users: Relationships to Spoken Language

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Sentence Recognition in Quiet and Noise by Pediatric Cochlear Implant Users: Relationships to Spoken Language: [image: image]Objective: We investigated associations between sentence recognition and spoken language for children with cochlear implants (CI) enrolled in the Childhood Development after Cochlear Implantation (CDaCI) study. Study Design: In a prospective longitudinal study, sentence recognition percent-correct scores and language standard scores were correlated at 48-, 60-, and 72-months post-CI activation. Setting: Six tertiary CI centers in the United States. Patients: Chi...περισσότερα »

Temporal-Bone Measurements of the Maximum Equivalent Pressure Output and Maximum Stable Gain of a Light-Driven Hearing System That Mechanically Stimulates the Umbo

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Temporal-Bone Measurements of the Maximum Equivalent Pressure Output and Maximum Stable Gain of a Light-Driven Hearing System That Mechanically Stimulates the Umbo: [image: image] Hypothesis: That maximum equivalent pressure output (MEPO) and maximum stable gain (MSG) measurements demonstrate high output and high gain margins in a light-driven hearing system (Earlens). Background: The nonsurgical Earlens consists of a light-activated balanced-armature transducer placed on the tympanic membrane (Lens) to drive the middle ear through direct umbo contact. The Lens is driven and powere... περισσότερα »

Speech Understanding in Children With Normal Hearing: Sound Field Normative Data for BabyBio, BKB-SIN, and QuickSIN

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Speech Understanding in Children With Normal Hearing: Sound Field Normative Data for BabyBio, BKB-SIN, and QuickSIN: [image: image]Objective: The primary goal was to establish normative data for the Pediatric AzBio “BabyBio,” QuickSIN, and BKB-SIN measures in the sound field for children with normal hearing. Setting: Tertiary care hospital; cochlear implant (CI) program. Patients: Forty-one children with normal hearing were recruited across four age groups (5–6, 7–8, 9–10, and 11–12 yr). Interventions: Sentence recognition testing was assessed at four different signal-to-noise ratios ... περισσότερα »

Comparisons of Longitudinal Trajectories of Social Competence: Parent Ratings of Children With Cochlear Implants Versus Hearing Peers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Comparisons of Longitudinal Trajectories of Social Competence: Parent Ratings of Children With Cochlear Implants Versus Hearing Peers: [image: image] Objective: To evaluate the longitudinal effects of cochlear implantation (CIs) on young, deaf children's social competence over 5 years of implant use and compare their social skills to those of same-aged, hearing peers. Study Design: Prospective, longitudinal between- and within-subjects design, with assessments completed 3 times over 5 years. Setting: This study was conducted at 6 cochlear implant centers and two preschools that enrol... περισσότερα »

Single-sided Deafness Cochlear Implantation: Candidacy, Evaluation, and Outcomes in Children and Adults

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Single-sided Deafness Cochlear Implantation: Candidacy, Evaluation, and Outcomes in Children and Adults: [image: image] Objectives: Although there are various available treatment options for unilateral severe-to-profound hearing loss, these options do not provide the benefits of binaural hearing since sound is directed from the poorer ear to the better ear. The purpose of this investigation was to review our center's experience with cochlear implantation in such patients in providing improved auditory benefits and useful binaural hearing. Study Design: Retrospective chart review. Me... περισσότερα »

Physical Activity and Survival After Prostate Cancer.

Alexandros G. SfakianakisστοHead and NeckΠριν από 15 δευτερόλεπτα
*Physical Activity and Survival After Prostate Cancer.* Eur Urol. 2016 Jan 7; Authors: Friedenreich CM, Wang Q, Neilson HK, Kopciuk KA, McGregor SE, Courneya KS Abstract BACKGROUND: Despite the high global prevalence of prostate cancer (PCa), few epidemiologic studies have assessed physical activity in relation to PCa survival. OBJECTIVE: To evaluate different types, intensities, and timing of physical activity relative to PCa survival. DESIGN, SETTING, AND PARTICIPANTS: A prospective study was conducted in Alberta, Canada, in a cohort of 830 stage II-IV incident PCa cases diagn... περισσότερα »

Cancer Imaging at the Crossroads of Precision Medicine: Perspective From an Academic Imaging Department in a Comprehensive Cancer Center.

Alexandros G. SfakianakisστοHead and NeckΠριν από 15 δευτερόλεπτα
*Cancer Imaging at the Crossroads of Precision Medicine: Perspective From an Academic Imaging Department in a Comprehensive Cancer Center.* J Am Coll Radiol. 2016 Jan 14; Authors: Van den Abbeele AD, Krajewski KM, Tirumani SH, Fennessy FM, DiPiro PJ, Nguyen QD, Harris GJ, Jacene HA, Lefever G, Ramaiya NH Abstract The authors propose one possible vision for the transformative role that cancer imaging in an academic setting can play in the current era of personalized and precision medicine by sharing a conceptual model that is based on experience and lessons learned designing a mul... περισσότερα »

[Radiotherapy of chloroma or granulocytic sarcoma: A literature review].

Alexandros G. SfakianakisστοHead and NeckΠριν από 15 δευτερόλεπτα
*[Radiotherapy of chloroma or granulocytic sarcoma: A literature review].* Cancer Radiother. 2016 Jan 13; Authors: Yossi S, de Talhouet S, Ducastelle-Leprêtre S, Hassouni A, Pigné G, Selmaji I, Samlali H, Ginoux M, Caraivan I, d'Hombres A Abstract Granulocytic sarcoma, or chloroma, is a rare clinical entity, usually associated with a blood disease, including acute myeloid leukemia. Management strategies are based on the combination of systemic therapy and local therapy (surgery or radiation). Data for radiotherapy dose are derived from retrospective studies and case reports. We c...περισσότερα »

Burkitt lymphoma in a child with Bloom syndrome.

Alexandros G. SfakianakisστοHead and NeckΠριν από 15 δευτερόλεπτα
*Burkitt lymphoma in a child with Bloom syndrome.* Arch Pediatr. 2016 Jan 7; Authors: Fedhila-Ben Ayed F, Douira-Khomsi W, Rhayem S, Jelassi M, Zribi H, Chaabouni M, Khemiri M, Bellagha I, Barsaoui S Abstract BACKGROUND: Bloom syndrome is a rare disease characterized by chromosomal instability and increased risk of developing lymphoma. OBSERVATION: We report on a case of Bloom syndrome in a 5-year-old boy with Burkitt lymphoma. The diagnosis was suspected by growth retardation, repeated respiratory infections, facial telangiectasia, and a low immunoglobulin level, then confirmed ... περισσότερα »

Deeper Cochlear Implant Electrode Insertion Angle Improves Detection of Musical Sound Quality Deterioration Related to Bass Frequency Removal

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Deeper Cochlear Implant Electrode Insertion Angle Improves Detection of Musical Sound Quality Deterioration Related to Bass Frequency Removal: [image: image]Background: Cochlear implant (CI) electrode arrays typically do not reach the most apical regions of the cochlea that intrinsically encode low frequencies. This may contribute to diminished implant-mediated musical sound quality perception. The objective of this study was to assess the effect of varying degrees of apical cochlear stimulation (measured by angular insertion depth) on musical sound quality discrimination. Hypothesis...περισσότερα »

Results of Postoperative, CT-based, Electrode Deactivation on Hearing in Prelingually Deafened Adult Cochlear Implant Recipients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Results of Postoperative, CT-based, Electrode Deactivation on Hearing in Prelingually Deafened Adult Cochlear Implant Recipients: [image: image] Objective: To test the use of a novel, image-guided cochlear implant (CI) programming (IGCIP) technique on prelingually deafened, adult CI recipients. Study Design: Prospective unblinded study. Setting: Tertiary referral center. Patients: Twenty-six prelingually deafened adult CI recipients with 29 CIs (3 bilateral). Intervention(s): Temporal-bone CT scans were used as input to a series of semiautomated computer algorithms which estimate the ... περισσότερα »

Does Bilateral Experience Lead to Improved Spatial Unmasking of Speech in Children Who Use Bilateral Cochlear Implants?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Does Bilateral Experience Lead to Improved Spatial Unmasking of Speech in Children Who Use Bilateral Cochlear Implants?: [image: image]Hypothesis: In children with bilateral cochlear implants (BiCIs), experience over a 1 to 3-year period can improve speech understanding and spatial unmasking of speech. Background: One reason for providing children with BiCIs is to improve spatial hearing abilities. Little is known about changes in performance with added bilateral experience, and the relation between sound localization and spatial unmasking of speech. Methods: Twenty children with BiC... περισσότερα »

Effects of Intralabyrinthine Hemorrhage on the Cochlear Elements: A Human Temporal Bone Study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Effects of Intralabyrinthine Hemorrhage on the Cochlear Elements: A Human Temporal Bone Study: [image: image]Hypothesis: To compare histopathologic findings in the cochlea of human temporal bones with versus without intralabyrinthine hemorrhage. Background: Hemorrhagic labyrinthitis can cause sensorineural damage, sudden hearing loss, and vertigo. Yet, to our knowledge, no studies have quantitatively described histopathologic effects of intralabyrinthine hemorrhage on the elements of the cochlea. Methods: We analyzed 46 human temporal bone samples from 23 patients with unilateral int... περισσότερα »

Induction of melasma by 1064-nm Q-switched neodymium:yttrium–aluminum–garnet laser therapy for acquired bilateral nevus of Ota-like macules (Hori nevus): A study on related factors in the Chinese population

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Induction of melasma by 1064-nm Q-switched neodymium:yttrium–aluminum–garnet laser therapy for acquired bilateral nevus of Ota-like macules (Hori nevus): A study on related factors in the Chinese population: Abstract Laser treatment has emerged as a common treatment modality for acquired bilateral nevus of Ota-like macules (ABNOM). To identify the ratio of melasma induction and exacerbation before and after laser therapy for ABNOM and to observe the risk factors related to the induction and exacerbation of melasma by laser therapy, we analyzed related factors of 1268 adult Chinese... περισσότερα »

Induction of melasma by 1064-nm Q-switched neodymium:yttrium–aluminum–garnet laser therapy for acquired bilateral nevus of Ota-like macules (Hori nevus): A study on related factors in the Chinese population

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 17 δευτερόλεπτα
Abstract Laser treatment has emerged as a common treatment modality for acquired bilateral nevus of Ota-like macules (ABNOM). To identify the ratio of melasma induction and exacerbation before and after laser therapy for ABNOM and to observe the risk factors related to the induction and exacerbation of melasma by laser therapy, we analyzed related factors of 1268 adult Chinese patients who underwent 1064-nm Q-switched neodymium:yttrium–aluminum–garnet (Nd:YAG) laser (QNYL) treatment using case series and case–control studies. Overall, 24.0% of the ABNOM patients had mixed melasma.... περισσότερα »

Cutaneous mastocytosis with bone anomalies of the inner ear and sinus pericranii in the parietal region

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 17 δευτερόλεπτα
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Frederick woman advocates for Death with Dignity bill – Frederick News Post (subscription)

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 20 δευτερόλεπτα
Frederick News Post (subscription) Frederick woman advocates for Death with Dignity bill Frederick News Post (subscription) For the last 23 years, Lloyd said her day-to-day life has been a mix of ongoing tests, chemotherapy, surgeries and doctors visits. She’s had 16 surgeries in that time, she said. Her larynx was removed after her throat cancer… Continue reading Frederick woman advocates for Death with Dignity bill – Frederick News Post (subscription)

Frederick woman advocates for Death with Dignity bill – Frederick News Post (subscription)

Frederick News Post (subscription) Frederick woman advocates for Death with Dignity bill Frederick News Post (subscription) For the last 23 years, Lloyd said her day-to-day life has been a mix of ongoing tests, chemotherapy, surgeries and doctors visits. She’s had 16 surgeries in that time, she said. Her larynx was removed after her throat cancer […]

Induction of melasma by 1064-nm Q-switched neodymium:yttrium–aluminum–garnet laser therapy for acquired bilateral nevus of Ota-like macules (Hori nevus): A study on related factors in the Chinese population

Abstract Laser treatment has emerged as a common treatment modality for acquired bilateral nevus of Ota-like macules (ABNOM). To identify the ratio of melasma induction and exacerbation before and after laser therapy for ABNOM and to observe the risk factors related to the induction and exacerbation of melasma by laser therapy, we analyzed related factors […]

Cutaneous mastocytosis with bone anomalies of the inner ear and sinus pericranii in the parietal region

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Margaret McCartney: Regulation doesn’t guarantee safety

The NHS does bad things. A young man with learning disability drowned in a bath while in its care. Subcultures have existed that have ignored cries of pain. The NHS has covered up events leading to… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1n6D9Cy via IFTTT

NICE guidelines on the menopause

The first National Institute for Health and Clinical Excellence guidelines on menopause appropriately highlight how symptoms may impair quality of life and function and persist for many years for… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SYqNZI via IFTTT

Half million US women at risk of genital mutilation, study finds

More than 500 000 women and girls in the United States are at risk of genital mutilation, researchers from the US Centers for Disease Control and Prevention have reported in a new study.1 Female… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SYqMVH via IFTTT

Zika virus outbreak prompts US to issue travel alert to pregnant women

Prompted by reports from Brazil linking Zika virus infection with a surge in cases of fetal and newborn microcephaly, the US Centers for Disease Control and Prevention has issued a travel alert… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SYqKx5 via IFTTT

Editorial

Dermatology from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Q98tdG via IFTTT

An Improved ARIMA-Based Traffic Anomaly Detection Algorithm for Wireless Sensor Networks

Traffic anomaly detection is emerging as a necessary component as wireless networks gain popularity. In this paper, based on the improved Autoregressive Integrated Moving Average (ARIMA) model, we propose a traffic anomaly detection algorithm for wireless sensor networks (WSNs) which considers the particular imbalanced, nonstationary properties of the WSN traffic and the limited energy and […]

Density and Optical Properties of {Ciprofloxacin Hydrochloride + Aqueous-Ethanol} Mixtures at 30°C

The paper deals with the calculation of molar refraction () and polarizability () of antibiotic drug ciprofloxacin hydrochloride ( = 0.001–0.029 mol·dm−3) solutions in ethanol-water mixtures of different compositions (30, 50, and 70% v/v) from measured density () and refractive index () at 30°C. The effect of drug concentration and composition of ethanol-water mixtures on density and […]

Keratotic condyloma acuminatum

from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1RvIXTb via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1WmBTYe via IFTTT

Completion thyroidectomy and total thyroidectomy for differentiated thyroid cancer: Comparison and prediction of postoperative hypoparathyroidism

ConclusionsAlthough temporary hypoparathyroidism was lower in the CT group, our analysis indicates the difference is due to the extent of CND rather than type of surgical procedure (CT vs. TT). Only bilateral CND is an independent risk factor for temporary hypoparathyroidism after thyroidectomy. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc. (Source: Journal of Surgical […]

Predictive Validity of the Youth Level of Service/Case Management Inventory with Youth who have Committed Sexual and Non-Sexual Offenses: The Utility of Professional Override

The predictive validity of the Youth Level of Service/Case Management Inventory (YLS/CMI) and the use of professional override were examined in a matched sample of youth who committed sexual (n = 204) and non-sexual (n = 185) offenses. Based on the actuarial score, the YLS/CMI obtained moderate to strong levels of predictive validity for non-violent, […]

Risk of malignant melanoma in men with prostate cancer: Nationwide, population‐based cohort study

In conclusion, men with low‐risk prostate cancer, high education, high income and residency in southern Sweden had an increased risk of early‐stage melanoma. (Source: International Journal of Cancer) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OZPNOm via IFTTT

Application of the HCR-20 Version 3 in Civil Psychiatric Patients

This study provides both a structural analysis of the Historical-Clinical-Risk Management–20 (HCR-20) Version 3 and an examination of the correspondence between the HCR-20 Versions 2 and 3. HCR-20 Versions 2 and 3 risk ratings were completed for 64 psychiatric inpatients. Moderate to good interrater reliability was observed for the Version 3 subscales and summary risk […]

Arrestees Perceptions of the Police: Exploring Procedural Justice, Legitimacy, and Willingness to Cooperate With Police Across Offender Types

Only a handful of studies have sought to explore the robustness of the relationship between procedural justice, police legitimacy, and willingness to cooperate with police among adults who have recently been arrested. The findings from those studies have raised questions about the durability of the framework for offenders, as well as whether there may be […]

Hodgkin and Reed–Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylati on

In this study, we have compared metabolic features of Hodgkin–Reed–Sternberg (HRS) cells, the tumor cells of classical Hodgkin’s lymphoma (cHL), one of the most frequent (post‐)GC‐derived B‐cell lymphomas, with their normal GC B cell counterparts. We found that the ratio of oxidative to nonoxidative energy conversion was clearly shifted toward oxidative phosphorylation (OXPHOS)‐linked ATP synthesis […]

A Meta-Analytic Review of Correctional Interventions for Women Offenders: Gender-Neutral Versus Gender-Informed Approaches

Using meta-analytic approaches, we examined whether interventions for women offenders are effective in reducing recidivism, as well as whether gender-informed and gender-neutral interventions differ in their effectiveness. Across 38 effect sizes reflecting 37 studies and nearly 22,000 women offenders, women who participated in correctional interventions had 22% to 35% greater odds of community success than […]

Taking Stock of the Relationship Between Gang Membership and Offending: A Meta-Analysis

This study takes stock of empirical research examining the relationship between gang membership and offending by subjecting this large body of work to a meta-analysis. Multilevel modeling is used to determine the overall mean effect size of this relationship based on 1,649 effect size estimates drawn from 179 empirical studies and 107 independent data sets. […]

Predictive Validity of the Youth Level of Service/Case Management Inventory with Youth who have Committed Sexual and Non-Sexual Offenses: The Utility of Professional Override

The predictive validity of the Youth Level of Service/Case Management Inventory (YLS/CMI) and the use of professional override were examined in a matched sample of youth who committed sexual (n = 204) and non-sexual (n = 185) offenses. Based on the actuarial score, the YLS/CMI obtained moderate to strong levels of predictive validity for non-violent, […]

Application of the HCR-20 Version 3 in Civil Psychiatric Patients

This study provides both a structural analysis of the Historical-Clinical-Risk Management–20 (HCR-20) Version 3 and an examination of the correspondence between the HCR-20 Versions 2 and 3. HCR-20 Versions 2 and 3 risk ratings were completed for 64 psychiatric inpatients. Moderate to good interrater reliability was observed for the Version 3 subscales and summary risk […]

Arrestees Perceptions of the Police: Exploring Procedural Justice, Legitimacy, and Willingness to Cooperate With Police Across Offender Types

Only a handful of studies have sought to explore the robustness of the relationship between procedural justice, police legitimacy, and willingness to cooperate with police among adults who have recently been arrested. The findings from those studies have raised questions about the durability of the framework for offenders, as well as whether there may be […]

A Meta-Analytic Review of Correctional Interventions for Women Offenders: Gender-Neutral Versus Gender-Informed Approaches

Using meta-analytic approaches, we examined whether interventions for women offenders are effective in reducing recidivism, as well as whether gender-informed and gender-neutral interventions differ in their effectiveness. Across 38 effect sizes reflecting 37 studies and nearly 22,000 women offenders, women who participated in correctional interventions had 22% to 35% greater odds of community success than […]

Taking Stock of the Relationship Between Gang Membership and Offending: A Meta-Analysis

This study takes stock of empirical research examining the relationship between gang membership and offending by subjecting this large body of work to a meta-analysis. Multilevel modeling is used to determine the overall mean effect size of this relationship based on 1,649 effect size estimates drawn from 179 empirical studies and 107 independent data sets. […]

The Heterogeneity of Treatment Needs for Justice-Involved Girls: A Typology Using Latent Class Analysis

Current efforts to identify the treatment needs of juveniles typically examine girls as a homogeneous group and recommendations for gender-responsive services tend to generalize needs to all girls. Research on within-girl heterogeneity suggests that this approach is shortsighted as treatment needs vary among justice-involved girls; however, little is known about how treatment needs cluster in […]

Pharmacokinetic Profile, Safety, and Tolerability of Crisaborole Topical Ointment, 2% in Adolescents with Atopic Dermatitis: An Open-Label Phase 2a Study

Abstract Background Phosphodiesterase-4 (PDE4) is an emerging target in treating inflammatory skin diseases. Crisaborole topical ointment, 2% is a novel, boron-based, topical PDE4 inhibitor under investigation for treatment of mild to moderate atopic dermatitis (AD). Methods Adolescent patients aged 12 to 17 years with treatable AD lesions involving ≥10% to ≤35% body surface area (BSA) […]

7T MRI in focal epilepsy with unrevealing conventional field strength imaging

Summary Objective To assess the diagnostic yield of 7T magnetic resonance imaging (MRI) in detecting and characterizing structural lesions in patients with intractable focal epilepsy and unrevealing conventional (1.5 or 3T) MRI. Methods We conducted an observational clinical imaging study on 21 patients (17 adults and 4 children) with intractable focal epilepsy, exhibiting clinical and […]

Multiple fixed drug eruption caused by ropinirole in a patient with Parkinson’s disease

Publication date: Available online 17 January 2016 Source:Allergology International Author(s): Natsuko Sasaki-Saito, Yu Sawada, Shun Ohmori, Daisuke Omoto, Sanehito Haruyama, Manabu Yoshioka, Daisuke Nishio, Motonobu Nakamura from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1WmDnBU via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Synovial sarcoma in children and adolescents.

[Synovial sarcoma in children and adolescents]. Bull Cancer. 2016 Jan 7; Authors: Mansuy L, Bernier V, Ranchère-Vince D, Mainard L, Orbach D, Corradini N Abstract Synovial sarcoma (SS) is a rare high-grade malignant mesenchymal tumor affecting children, adolescents, and young adults. Cytogenetically, more than 90% of SS is characterized by the t(X;18)(p11.2;q11.2), translocation resulting in […]

An Online Three-Class Transcranial Doppler Ultrasound Brain Computer Interface

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 43 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 18 January 2016 *Source:*Neuroscience Research Author(s): Anuja Goyal, Ali-Akbar Samadani, Anne-Marie Guerguerian, Tom Chau Brain computer interfaces (BCI) can provide communication opportunities for individuals with severe motor disabilities. Transcranial Doppler ultrasound (TCD) measures cerebral blood flow velocities and can be used to develop a BCI. A previously implemented TCD BCI system used verbal and spatial tasks as control signals; however, the spatial task involved a visual cue that awkwardly diverted the user's att...περισσότερα »

Genetic risk factors of cisplatin induced ototoxicity in adult patients.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Genetic risk factors of cisplatin induced ototoxicity in adult patients.* Neoplasma. 2016 Jan 17;63(2) Authors: Talach T, Rottenberg J, Gal B, Kostrica R, Jurajda M, Kocak I, Lakomy R, Vogazianos E Abstract Ototoxicity is an important adverse effect of using Cisplatin (cis-diamminedichloroplatinum) (CDDP) as a form of chemotherapy. The clinical picture of CDDP induced ototoxicity includes perceptive hearing impairment (reversible or permanent) and tinnitus. Ototoxicity manifests with considerable variability between patients. The objective of this prospective study was to inves... περισσότερα »

Audible sphenoid-sellar fistula: An unusual complication of transphenoidal surgery.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Audible sphenoid-sellar fistula: An unusual complication of transphenoidal surgery.* Laryngoscope. 2016 Jan 17; Authors: Alfonso KP, Comer BT Abstract Eustachian tube problems are relatively common complaints to otolaryngologists' offices. However, clinicians should consider other possibilities when traditional therapies fail to improve symptoms. We present a previously not described case of sphenoid-sellar fistula after transphenoidal surgery causing objective and subjective clicking. LEVEL OF EVIDENCE: NA Laryngoscope, 2015. PMID: 26774438 [PubMed - as supplied by publisher] ...περισσότερα »

[Radiotherapy of chloroma or granulocytic sarcoma: A literature review].

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*[Radiotherapy of chloroma or granulocytic sarcoma: A literature review].* Cancer Radiother. 2016 Jan 13; Authors: Yossi S, de Talhouet S, Ducastelle-Leprêtre S, Hassouni A, Pigné G, Selmaji I, Samlali H, Ginoux M, Caraivan I, d'Hombres A Abstract Granulocytic sarcoma, or chloroma, is a rare clinical entity, usually associated with a blood disease, including acute myeloid leukemia. Management strategies are based on the combination of systemic therapy and local therapy (surgery or radiation). Data for radiotherapy dose are derived from retrospective studies and case reports. We c...περισσότερα »

Burkitt lymphoma in a child with Bloom syndrome.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Burkitt lymphoma in a child with Bloom syndrome.* Arch Pediatr. 2016 Jan 7; Authors: Fedhila-Ben Ayed F, Douira-Khomsi W, Rhayem S, Jelassi M, Zribi H, Chaabouni M, Khemiri M, Bellagha I, Barsaoui S Abstract BACKGROUND: Bloom syndrome is a rare disease characterized by chromosomal instability and increased risk of developing lymphoma. OBSERVATION: We report on a case of Bloom syndrome in a 5-year-old boy with Burkitt lymphoma. The diagnosis was suspected by growth retardation, repeated respiratory infections, facial telangiectasia, and a low immunoglobulin level, then confirmed ... περισσότερα »

Chronic intermittent abdominal pain in young woman with intestinal malrotation, Fitz-Hugh-Curtis Syndrome and appendiceal neuroendocrine tumor: a rare case report and literature review.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Chronic intermittent abdominal pain in young woman with intestinal malrotation, Fitz-Hugh-Curtis Syndrome and appendiceal neuroendocrine tumor: a rare case report and literature review.* BMC Womens Health. 2016;16(1):3 Authors: Cusimano A, Abdelghany AM, Donadini A Abstract BACKGROUND: There are a lot of different causes of abdominal pain; in this case, a young woman suffers from three diseases with similar symptoms. Adult intestinal mal-rotation is a rare condition of deviation from the normal 270° counter clockwise rotation of the midgut resulting in, not only mal-position of...περισσότερα »

Desmoid tumor of lung with pleural involvement - the case of unique location of aggressive fibromatosis.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Desmoid tumor of lung with pleural involvement - the case of unique location of aggressive fibromatosis.* Folia Med Cracov. 2015;55(1):53-59 Authors: Tokarek T, Szpor J, Pankowski J, Okoń K Abstract Desmoid tumors (DTs) are rare mesenchymal neoplasms with unpredictable natural history. There is a high risk of recurrence despite adequate surgical resection, however DTs do not have the capacity to metastasize. The estimated incidence in general population is 2-4 cases/million/year. They may occur at any age but most commonly in the third and fourth decades. Both sexes may be affe... περισσότερα »

Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy.* Clin Breast Cancer. 2015 Dec 1; Authors: Jhaveri K, Teplinsky E, Silvera D, Valeta-Magara A, Arju R, Giashuddin S, Sarfraz Y, Alexander M, Darvishian F, Levine PH, Hashmi S, Zolfaghari L, Hoffman HJ, Singh B, Goldberg JD, Hochman T, Formenti S, Esteva FJ, Moran MS, Schneider RJ Abstract INTRODUCTION: Inflammatory breast cancer (IBC) is an aggressive and rare cancer with a poor prognosis and a need fo...περισσότερα »

Congenital oval or round window malformations in children: Surgical findings and results in 17 cases.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Congenital oval or round window malformations in children: Surgical findings and results in 17 cases.* Laryngoscope. 2016 Jan 17; Authors: Vincent R, Wegner I, Derks LS, Grolman W Abstract OBJECTIVES/HYPOTHESIS: To prospectively evaluate surgical findings and hearing results in children undergoing surgery for congenital oval or round window malformations (class IV malformations). STUDY DESIGN: A nonrandomized, nonblinded, case series of prospectively collected data. METHODS: Fourteen consecutive pediatric patients who underwent 17 surgical procedures for congenital oval or round... περισσότερα »

Assessment of pediatric obstructive sleep apnea using a drug-induced sleep endoscopy rating scale.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Assessment of pediatric obstructive sleep apnea using a drug-induced sleep endoscopy rating scale.* Laryngoscope. 2016 Jan 17; Authors: Lam DJ, Weaver EM, Macarthur CJ, Milczuk HA, O'Neill E, Smith TL, Nguyen T, Shea SA Abstract OBJECTIVES/HYPOTHESIS: Assess the reliability of a Sleep Endoscopy Rating Scale (SERS) and its relationship with pediatric obstructive sleep apnea (OSA) severity. STUDY DESIGN: Retrospective case series of pediatric patients who underwent drug-induced sleep endoscopy (DISE) at the time of surgery for OSA from January 1, 2013 to May 1, 2014. METHODS: Thr... περισσότερα »

Stem cell approaches for vocal fold regeneration.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Stem cell approaches for vocal fold regeneration.* Laryngoscope. 2016 Jan 17; Authors: Fishman JM, Long J, Gugatschka M, De Coppi P, Hirano S, Hertegard S, Thibeault SL, Birchall MA Abstract OBJECTIVES/HYPOTHESIS: Current interventions in the management of vocal fold (VF) dysfunction focus on conservative and surgical approaches. However, the complex structure and precise biomechanical properties of the human VF mean that these strategies have their limitations in clinical practice and in some cases offer inadequate levels of success. Regenerative medicine is an exciting develo...περισσότερα »

Does a multidisciplinary team approach in a tertiary referral centre impact on the initial management of head and neck cancer?

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Does a multidisciplinary team approach in a tertiary referral centre impact on the initial management of head and neck cancer?* Oral Oncol. 2016 Jan 13; Authors: Bergamini C, Locati L, Bossi P, Granata R, Alfieri S, Resteghini C, Imbimbo M, Fallai C, Orlandi E, Tana S, Iacovelli NA, Guzzo M, Ibba T, Colombo S, Bianchi R, Pizzi N, Fontanella W, Licitra L Abstract OBJECTIVES: A multi-disciplinary team (MDT) is essential in the management of cancer. Head and neck cancer (HNC) is a rare, complex and heterogeneous group of malignancies for which different treatment options are availa... περισσότερα »

The role of autophagy in squamous cell carcinoma of the head and neck.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*The role of autophagy in squamous cell carcinoma of the head and neck.* Oral Oncol. 2016 Jan 7; Authors: Cosway B, Lovat P Abstract Half a million new head and neck cancers are diagnosed each year worldwide. Although traditionally thought to be triggered by alcohol and smoking abuse, there is a growing subset of oropharyngeal cancers driven by the oncogenic human papilloma virus (HPV). Despite advances in both surgical and non-surgical treatment strategies, survival rates have remained relatively static emphasising the need for novel therapeutic approaches. Autophagy, the princ...περισσότερα »

Measurements of the Acoustic Speaking Voice After Vocal Warm-up and Cooldown in Choir Singers.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Measurements of the Acoustic Speaking Voice After Vocal Warm-up and Cooldown in Choir Singers.* J Voice. 2016 Jan 14; Authors: Onofre F, Prado YA, Rojas GV, Garcia DM, Aguiar-Ricz L Abstract OBJECTIVES: The aim of this study was to evaluate the acoustic measurements of the vowel /a/ in modal recording before and after a singing voice resistance test and after 30 minutes of absolute rest in female choir singers. STUDY DESIGN: This is a prospective cohort study. METHODS: A total of 13 soprano choir singers with experience in choir singing were evaluated through analysis of acousti...περισσότερα »

Frailty in Geriatric Glioblastoma Patients: A Predictor of Operative Morbidity and Outcome.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Frailty in Geriatric Glioblastoma Patients: A Predictor of Operative Morbidity and Outcome.* World Neurosurg. 2016 Jan 13; Authors: Cloney M, D'Amico R, Lebovic J, Nazarian M, Zacharia BE, Sisti MB, Bruce JN, McKhann GM, Iwamoto FM, Sonabend AM Abstract INTRODUCTION: Frailty is an emerging means of assessing overall health status and guiding management for geriatric patients. Frailty is associated with outcomes for many surgical indications in this age group. While half of all glioblastoma patients are 65 years old or older, frailty has not been examined in relation to surgery ... περισσότερα »

Management of subarachnoid hemorrhage in two important Italian political leaders: a paradigm of ethical and technological evolution of neurosurgery during the past half-century.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Management of subarachnoid hemorrhage in two important Italian political leaders: a paradigm of ethical and technological evolution of neurosurgery during the past half-century.* World Neurosurg. 2016 Jan 13; Authors: Longatti P, Giombelli E, Pavesi G, Carteri A, Feletti A Abstract For a curious and extraordinary coincidence, 5 out of 7 most relevant leaders of the Italian Communist Party (Partito Comunista Italiano, PCI, which was established in 1921, has been the biggest Communist Party in Western Countries) suffered a cerebral stroke. Cerebrovascular diseases afflicted also ... περισσότερα »

Two-fold illumination in topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) for superficial basal cell carcinoma (sBCC): A retrospective case series and cohort study.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Two-fold illumination in topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) for superficial basal cell carcinoma (sBCC): A retrospective case series and cohort study.* J Am Acad Dermatol. 2016 Jan 13; Authors: Kessels J, Hendriks J, Nelemans P, Mosterd K, Kelleners-Smeets N Abstract BACKGROUND: There is limited literature on efficacy using a 2-fold illumination scheme in aminolevulinic acid (ALA) photodynamic therapy for superficial basal cell carcinoma (sBCC). OBJECTIVES: We sought to determine the efficacy of ALA photodynamic therapy for sBCC using a 2-fol...περισσότερα »

Pelvic-perineal reconstruction with the combined transverse upper gracilis and profunda artery perforator (TUG-PAP) flap.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Pelvic-perineal reconstruction with the combined transverse upper gracilis and profunda artery perforator (TUG-PAP) flap.* J Plast Reconstr Aesthet Surg. 2015 Dec 17; Authors: Ciudad P, Dower R, Nicoli F, Orfaniotis G, Maruccia M, Constantinescu T, Lin SP, Wang GJ, Chen HC PMID: 26774373 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/209qugL via IFTTT

Salvage of a complex first metatarso-phalangeal joint injury and synchronous reconstruction of medial collateral ligament and soft tissue with a distally based medial plantar artery flap.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Salvage of a complex first metatarso-phalangeal joint injury and synchronous reconstruction of medial collateral ligament and soft tissue with a distally based medial plantar artery flap.* J Plast Reconstr Aesthet Surg. 2016 Jan 6; Authors: Javed MU, Josty IC PMID: 26774358 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/209qvB5 via IFTTT

Scrotal reconstruction with modified pudendal thigh flaps.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Scrotal reconstruction with modified pudendal thigh flaps.* J Plast Reconstr Aesthet Surg. 2015 Nov 18; Authors: Mopuri N, Fitzgerald O'Connor E, Iwuagwu FC Abstract Scrotal skin loss can occur following trauma, Fournier's gangrene, post tumour excision, burns, etc. There are many techniques described in the literature including residual scrotal skin mobilization, skin grafts, pedicled and free flaps. The management is complex and challenging shown by the multiplicity of flaps and techniques described in the literature. We used a modified pudendal thigh flap to reconstruct scrot... περισσότερα »

MEDULLARY MEDIATION OF THE LARYNGEAL ADDUCTOR REFLEX: A POSSIBLE ROLE IN SUDDEN INFANT DEATH SYNDROME.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*MEDULLARY MEDIATION OF THE LARYNGEAL ADDUCTOR REFLEX: A POSSIBLE ROLE IN SUDDEN INFANT DEATH SYNDROME.* Respir Physiol Neurobiol. 2016 Jan 13; Authors: Wang X, Guo R, Zhao W, Pilowsky PM Abstract The laryngeal adductor reflex (LAR) is a laryngeal protective reflex. Vagal afferent polymodal sensory fibres that have cell bodies in the nodose ganglion, originate in the sub-glottal area of the larynx and upper trachea. These polymodal sensory fibres respond to mechanical or chemical stimuli. The central axons of these sensory vagal neurons terminate in the dorsolateral subnuclei of... περισσότερα »

Thyroid compressive mass, a metastasis of femur chondrosarcoma after 14 years: case report and literature review.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Thyroid compressive mass, a metastasis of femur chondrosarcoma after 14 years: case report and literature review.* Braz J Otorhinolaryngol. 2015 Dec 18; Authors: Simon F, Classe M, Vironneau P, Wassef M, Herman P, Le Clerc N PMID: 26774495 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/209qtt7 via IFTTT

De novo gastric adenocarcinoma 1 year after sleeve gastrectomy in a transplant patient.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*De novo gastric adenocarcinoma 1 year after sleeve gastrectomy in a transplant patient.* Int J Surg Case Rep. 2016 Jan 7;20:10-13 Authors: Masrur M, Elli E, Gonzalez-Ciccarelli LF, Giulianotti PC Abstract INTRODUCTION: It has been reported in the literature that upper gastrointestinal malignancies after bariatric surgery are mostly gastro-esophageal, although it is not clear whether bariatric surgery represents a risk factor for the development of esophageal and/or gastric cancer. We report a case of a de novo gastric adenocarcinoma occurring in a transplant patient 1 year afte... περισσότερα »

Pneumatosis cystoidis intestinalis presenting as bowel perforation, a rare entity.

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 46 δευτερόλεπτα
*Pneumatosis cystoidis intestinalis presenting as bowel perforation, a rare entity.* Int J Surg Case Rep. 2016 Jan 7;20:7-9 Authors: Hanna P, Kassir R, Tarek D, Bassile B, Saint-Eve P, Elias B Abstract INTRODUCTION: Pneumatosis cystoides intestinalis (PCI) is an uncommon condition. This following article describes a case of primary PCI presenting as acute abdomen due to perforation of a small bowel cyst. PRESENTATION OF CASE: This following article describes the case of an 88 year-old woman admitted at the hospital with peritonitis and consequently operated for a presumed bowel i...περισσότερα »

Il lipofilling al terzo posto tra le procedure Soft Cod: 871

IL LIPOFILLING DEL SENO E GLUTEI A PERUGIA Il lipofilling è una procedura naturale e sicura che permette di ridefinire alcune zone del corpo come il seno e i glutei. L’International Society of Aesthetic Plastic Surgery Associazione di chirurghi Plastici nel mondo , ci informa che il Lipofilling si colloca al 3° posto tra le […]

Other viewpoint: Biden can build on cancer victories – Columbus Dispatch

Other viewpoint: Biden can build on cancer victories Columbus Dispatch But, ominously, some cancers still are on the rise, including certain types of leukemia and cancers of the tongue, tonsil, small intestine, liver, pancreas, kidney and thyroid. Researchers say they are poised to make dramatic new advances in the coming … and more » from […]

516 Bird Feet in 3000 Square Feet

Call it the ultimate bird’s eye view of evolution: in Ithaca, NY the paint is barely dry on an ambitious 3000-square-foot mural celebrating the stunning diversity of birds.

A Phase I Trial of Temsirolimus and Pemetrexed in Patients with Advanced Non-Small Cell Lung Cancer

Conclusion: The combination of pemetrexed and temsirolimus is feasible and well tolerated. This combination may be further evaluated in patients with mTOR pathway activation, particularly in those with TSC1 or STK11 mutations.Chemotherapy 2015–16;61:144–147 (Source: Chemotherapy) from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SruJ5Y via IFTTT

Antibiotics and Breastfeeding

This article provides information on the main antibiotics that are appropriate for clinical use and the interference of these antibiotics with the infant to support medical decisions regarding the discontinuation of breastfeeding. We aim to provide information on the pharmacokinetic factors that interfere with the passage of antibiotics into breast milk and the toxicological implications […]

Quality of life after intervention with a cochlear implant or hearing aid.

Quality of life after intervention with a cochlear implant or hearing aid. Laryngoscope. 2016 Jan 17; Authors: Contrera KJ, Betz J, Li L, Blake CR, Sung YK, Choi JS, Lin FR Abstract OBJECTIVES/HYPOTHESIS: To investigate the impact of hearing aid and cochlear implant use on quality of life in adults. STUDY DESIGN: Prospective observational cohort […]

Quality standards for rheumatology outpatient clinic. The EXTRELLA project.

Quality standards for rheumatology outpatient clinic. The EXTRELLA project. Reumatol Clin. 2016 Jan 13; Authors: Nolla JM, Martínez C, García-Vicuña R, Seoane-Mato D, Rosario Lozano MP, Alonso A, Alperi M, Barbazán C, Calvo J, Delgado C, Fernández-Nebro A, Mateo L, Pérez Sandoval T, Pérez Venegas J, Rodríguez Lozano C, Rosas J, Grupo de Trabajo del […]

Exploring the preventable causes of unplanned readmissions using root cause analysis: Coordination of care is the weakest link.

Exploring the preventable causes of unplanned readmissions using root cause analysis: Coordination of care is the weakest link. Eur J Intern Med. 2016 Jan 13; Authors: Fluitman KS, van Galen LS, Merten H, Rombach SM, Brabrand M, Cooksley T, Nickel CH, Subbe CP, Kramer MH, Nanayakkara PW, safer@home consortium Abstract IMPORTANCE: Unplanned readmissions within 30days […]

Keratotic condyloma acuminatum

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 48 δευτερόλεπτα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1RvIXTb via IFTTT

Acute edema/cutaneous distension syndrome representing as eczéma craquelé-like change: A case and published work review

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 48 δευτερόλεπτα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1RvIZdD via IFTTT

Treatment of lipoid proteinosis with acitretin in two patients from two unrelated Chinese families with novel nonsense mutations of the ECM1 gene

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 48 δευτερόλεπτα
Abstract Lipoid proteinosis is a rare recessive genetic disorder caused by loss-of-function mutations to chromosome 1 at 1q21, the extracellular matrix protein 1 (ECM1) gene. Two children with lipoid proteinosis were reported from two unrelated Chinese families, both manifesting with a typical hoarse voice, white acne-like atrophic lesions and scarring on the skin, and beaded papules around the eyelids. The diagnosis had been confirmed by laboratory tests, skin biopsy and laryngoscope examination. Genomic DNA sequencing was performed for both children and their family members. The... περισσότερα »

Epidermodysplasia verruciformis-related human papillomavirus 76 was isolated from plantar warts of a healthy individual

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 48 δευτερόλεπτα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1RvIYX2 via IFTTT

Water-based correction fluid is a useful skin marker for determination of the tumor margin of basal cell carcinoma under high-frequency ultrasound

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 48 δευτερόλεπτα
Abstract We propose a new method to determine the appropriate preoperative surgical margin of basal cell carcinoma (BCC) by using water-based correction fluid as a skin marker showing the tumor position on the skin under high-frequency ultrasound (HFUS). After a provisional evaluation by dermoscopy, an approximately 2-mm dot of water-based correction fluid is applied to the tumor margin. The ultrasound waves are blocked by the dot of correction fluid, and a low-signal column is observed under the dot of correction fluid. The dots of correction fluid are moved and located as near a... περισσότερα »

Serum levels of interleukin-18-binding protein isoform a: Clinical association with inflammation and pulmonary hypertension in systemic sclerosis

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 48 δευτερόλεπτα
Abstract Systemic sclerosis (SSc) is a chronic autoimmune inflammatory disease characterized by extensive tissue fibrosis and various vascular complications. A wealth of evidence suggests the substantial contribution of pro-inflammatory cytokines to the development of SSc, but the role of interleukin (IL)-18 signaling in this disease still remains elusive. To address this issue, we herein determined serum levels of IL-18-binding protein isoform a (IL-18BPa), a soluble decoy receptor for IL-18, by enzyme-linked immunosorbent assay in 57 SSc patients and 20 healthy controls and eval...περισσότερα »

Case of classic Kaposi's sarcoma

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 48 δευτερόλεπτα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1OAlPgg via IFTTT

Association of psoriasis with Hashimoto's thyroiditis, Sjögren's syndrome and dermatomyositis

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 48 δευτερόλεπτα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1RvIWOT via IFTTT

Case of malignant melanoma that developed the ability to secrete granulocyte colony-stimulating factor

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 48 δευτερόλεπτα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1RvIWyr via IFTTT

Cutaneous granulomatous panniculitis and sarcoidal granulomatous papular eruption in a patient with metastatic melanoma treated with a BRAF inhibitor

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 48 δευτερόλεπτα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1RvIUXo via IFTTT

Trends in upper gastro-intestinal cancer among the elderly in Denmark, 1980-2012.

Conclusion There is a need for clinical trials focusing on patients over the age of 70 years with co-existing comorbidity. PMID: 26765771 [PubMed – as supplied by publisher] (Source: Acta Oncologica) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RvLBbi via IFTTT

Trends in cancer of the head and neck in the elderly in Denmark, 1980-2012.

Conclusion HNSCC is a rare disease in patients above 70 years accounting for only 17% of all HNSCC patients. Incidence rates increased over time, but age-specific survival rates improved, especially in younger patients. Failure rates to comply with radiation treatment, however, were low in both young and elderly patients. PMID: 26760291 [PubMed – as supplied […]

Tuberculosis reactivation in a patient receiving anti-programmed death-1 (PD-1) inhibitor for relapsed Hodgkin’s lymphoma.

Authors: Lee JJ, Chan A, Tang T PMID: 26754959 [PubMed – as supplied by publisher] (Source: Acta Oncologica) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RvLzAr via IFTTT

The effect of training during treatment with chemotherapy on muscle strength and endurance capacity: A systematic review.

Conclusions This review indicates that training during chemotherapy may help in preventing the decrease in muscle strength and endurance capacity. It is important to know which training intensity and duration is the most effective in training cancer patients, to provide a training program suitable for every cancer patient. Training should be based on good research […]

Study shows less physically mature ice hockey players have prolonged concussion symptoms

A study led by a Hasbro Children’s Hospital sports medicine physician found that male student ice hockey players in earlier pubertal stages had a significantly increased risk of prolonged symptoms… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PB1FCF via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

USPIO-enhanced 3D-cine self-gated cardiac MRI based on a stack-of-stars golden angle short echo time sequence: Application on mice with acute myocardial infarction

Purpose To develop and assess a 3D-cine self-gated method for cardiac imaging of murine models. Materials and Methods A 3D stack-of-stars (SOS) short echo time (STE) sequence with a navigator echo was performed at 7T on healthy mice (n = 4) and mice with acute myocardial infarction (MI) (n = 4) injected with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles. […]

Diagnostic quality assessment of compressed sensing accelerated magnetic resonance neuroimaging

Purpose To determine the efficacy of compressed sensing (CS) reconstructions for specific clinical magnetic resonance neuroimaging applications beyond more conventional acceleration techniques such as parallel imaging (PI) and low-resolution acquisitions. Materials and Methods Raw k-space data were acquired from five healthy volunteers on a 3T scanner using a 32-channel head coil using T2-FLAIR, FIESTA-C, time […]

Diffusion-Weighted imaging and diffusion tensor imaging detect delayed graft function and correlate with allograft fibrosis in patients early after kidney transplantation

Purpose To combine diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) for detection of allograft dysfunction in patients early after kidney transplantation and to correlate diffusion parameters with renal function and renal histology of allograft biopsies. Materials and Methods Between day 4 and 11 after kidney transplantation 33 patients with initial graft function and 31 […]

Use of texture analysis based on contrast-enhanced MRI to predict treatment response to chemoradiotherapy in nasopharyngeal carcinoma

Purpose To explore the clinical potential of texture analysis using contrast-enhanced 3.0T magnetic resonance imaging (MRI) for predicting the therapeutic response of nasopharyngeal carcinoma (NPC) to chemoradiotherapy. Materials and Methods The dataset comprised pretreatment T1-, T2-, and diffusion-weighted MR images from 53 eligible patients with newly diagnosed NPC. The patients were divided into two sets: […]

Comments regarding “Simplified Bernoulli’s method significantly underestimates pulmonary transvalvular pressure drop”

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Km4cPD via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

The role of autophagy in squamous cell carcinoma of the head and neck.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*The role of autophagy in squamous cell carcinoma of the head and neck.* Oral Oncol. 2016 Jan 7; Authors: Cosway B, Lovat P Abstract Half a million new head and neck cancers are diagnosed each year worldwide. Although traditionally thought to be triggered by alcohol and smoking abuse, there is a growing subset of oropharyngeal cancers driven by the oncogenic human papilloma virus (HPV). Despite advances in both surgical and non-surgical treatment strategies, survival rates have remained relatively static emphasising the need for novel therapeutic approaches. Autophagy, the princ...περισσότερα »

Measurements of the Acoustic Speaking Voice After Vocal Warm-up and Cooldown in Choir Singers.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Measurements of the Acoustic Speaking Voice After Vocal Warm-up and Cooldown in Choir Singers.* J Voice. 2016 Jan 14; Authors: Onofre F, Prado YA, Rojas GV, Garcia DM, Aguiar-Ricz L Abstract OBJECTIVES: The aim of this study was to evaluate the acoustic measurements of the vowel /a/ in modal recording before and after a singing voice resistance test and after 30 minutes of absolute rest in female choir singers. STUDY DESIGN: This is a prospective cohort study. METHODS: A total of 13 soprano choir singers with experience in choir singing were evaluated through analysis of acousti...περισσότερα »

First clinical application of a prompt gamma based in vivo proton range verification system.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*First clinical application of a prompt gamma based in vivo proton range verification system.* Radiother Oncol. 2016 Jan 13; Authors: Richter C, Pausch G, Barczyk S, Priegnitz M, Keitz I, Thiele J, Smeets J, Stappen FV, Bombelli L, Fiorini C, Hotoiu L, Perali I, Prieels D, Enghardt W, Baumann M Abstract BACKGROUND AND PURPOSE: To improve precision of particle therapy, in vivo range verification is highly desirable. Methods based on prompt gamma rays emitted during treatment seem promising but have not yet been applied clinically. Here we report on the worldwide first clinical ap...περισσότερα »

Chronic intermittent abdominal pain in young woman with intestinal malrotation, Fitz-Hugh-Curtis Syndrome and appendiceal neuroendocrine tumor: a rare case report and literature review.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Chronic intermittent abdominal pain in young woman with intestinal malrotation, Fitz-Hugh-Curtis Syndrome and appendiceal neuroendocrine tumor: a rare case report and literature review.* BMC Womens Health. 2016;16(1):3 Authors: Cusimano A, Abdelghany AM, Donadini A Abstract BACKGROUND: There are a lot of different causes of abdominal pain; in this case, a young woman suffers from three diseases with similar symptoms. Adult intestinal mal-rotation is a rare condition of deviation from the normal 270° counter clockwise rotation of the midgut resulting in, not only mal-position of...περισσότερα »

Desmoid tumor of lung with pleural involvement - the case of unique location of aggressive fibromatosis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Desmoid tumor of lung with pleural involvement - the case of unique location of aggressive fibromatosis.* Folia Med Cracov. 2015;55(1):53-59 Authors: Tokarek T, Szpor J, Pankowski J, Okoń K Abstract Desmoid tumors (DTs) are rare mesenchymal neoplasms with unpredictable natural history. There is a high risk of recurrence despite adequate surgical resection, however DTs do not have the capacity to metastasize. The estimated incidence in general population is 2-4 cases/million/year. They may occur at any age but most commonly in the third and fourth decades. Both sexes may be affe... περισσότερα »

Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy.* Clin Breast Cancer. 2015 Dec 1; Authors: Jhaveri K, Teplinsky E, Silvera D, Valeta-Magara A, Arju R, Giashuddin S, Sarfraz Y, Alexander M, Darvishian F, Levine PH, Hashmi S, Zolfaghari L, Hoffman HJ, Singh B, Goldberg JD, Hochman T, Formenti S, Esteva FJ, Moran MS, Schneider RJ Abstract INTRODUCTION: Inflammatory breast cancer (IBC) is an aggressive and rare cancer with a poor prognosis and a need fo...περισσότερα »

Physical Activity and Survival After Prostate Cancer.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Physical Activity and Survival After Prostate Cancer.* Eur Urol. 2016 Jan 7; Authors: Friedenreich CM, Wang Q, Neilson HK, Kopciuk KA, McGregor SE, Courneya KS Abstract BACKGROUND: Despite the high global prevalence of prostate cancer (PCa), few epidemiologic studies have assessed physical activity in relation to PCa survival. OBJECTIVE: To evaluate different types, intensities, and timing of physical activity relative to PCa survival. DESIGN, SETTING, AND PARTICIPANTS: A prospective study was conducted in Alberta, Canada, in a cohort of 830 stage II-IV incident PCa cases diagn... περισσότερα »

A Phase I Trial of Temsirolimus and Pemetrexed in Patients with Advanced Non-Small Cell Lung Cancer

Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Conclusion: The combination of pemetrexed and temsirolimus is feasible and well tolerated. This combination may be further evaluated in patients with mTOR pathway activation, particularly in those with TSC1 or STK11 mutations.Chemotherapy 2015–16;61:144–147 (Source: Chemotherapy) from Chemotherapy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SruJ5Y via IFTTT

A Phase I Trial of Temsirolimus and Pemetrexed in Patients with Advanced Non-Small Cell Lung Cancer

Conclusion: The combination of pemetrexed and temsirolimus is feasible and well tolerated. This combination may be further evaluated in patients with mTOR pathway activation, particularly in those with TSC1 or STK11 mutations.Chemotherapy 2015–16;61:144–147 (Source: Chemotherapy) from Chemotherapy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SruJ5Y via IFTTT

Antibiotics and Breastfeeding

This article provides information on the main antibiotics that are appropriate for clinical use and the interference of these antibiotics with the infant to support medical decisions regarding the discontinuation of breastfeeding. We aim to provide information on the pharmacokinetic factors that interfere with the passage of antibiotics into breast milk and the toxicological implications […]

Il lipofilling al terzo posto tra le procedure Soft Cod: 871

IL LIPOFILLING DEL SENO E GLUTEI A PERUGIA Il lipofilling è una procedura naturale e sicura che permette di ridefinire alcune zone del corpo come il seno e i glutei. L’International Society of Aesthetic Plastic Surgery Associazione di chirurghi Plastici nel mondo , ci informa che il Lipofilling si colloca al 3° posto tra le […]

Angina and associated healthcare costs following percutaneous coronary intervention: A real-world analysis from a multi-payer database.

Angina and associated healthcare costs following percutaneous coronary intervention: A real-world analysis from a multi-payer database. Catheter Cardiovasc Interv. 2016 Jan 17; Authors: Ben-Yehuda O, Kazi DS, Bonafede M, Wade SW, Machacz SF, Stephens LA, Hlatky MA, Hernandez JB Abstract OBJECTIVES: To study the contemporary, real-world clinical and economic burden associated with angina after percutaneous […]

An Event-Based Approach to Design a Teamwork Training Scenario and Assessment Tool in Surgery.

An Event-Based Approach to Design a Teamwork Training Scenario and Assessment Tool in Surgery. J Surg Educ. 2016 Jan 13; Authors: Nguyen N, Watson WD, Dominguez E Abstract OBJECTIVE: Simulation is a technique recommended for teaching and measuring teamwork, but few published methodologies are available on how best to design simulation for teamwork training in […]

Depression screening after cardiac surgery: A six month longitudinal follow up for cardiac events, hospital readmissions, quality of life and mental health.

Depression screening after cardiac surgery: A six month longitudinal follow up for cardiac events, hospital readmissions, quality of life and mental health. Int J Cardiol. 2016 Jan 7;206:44-50 Authors: Tully PJ, Baumeister H, Bennetts JS, Rice GD, Baker RA Abstract OBJECTIVES: To report the 6-month longitudinal outcomes of routine depression screening in cardiac patients. METHODS: […]

Colorimetric recognition of pazufloxacin mesilate based on the aggregation of gold nanoparticles.

Colorimetric recognition of pazufloxacin mesilate based on the aggregation of gold nanoparticles. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 9;157:244-250 Authors: Kong S, Liao M, Gu Y, Li N, Wu P, Zhang T, He H Abstract A novel colorimetric nanomaterial-assisted optical sensor for pazufloxacin mesilate was proposed for the first time. Pazufloxacin mesilate could […]

A critical appraisal of nutritional intervention studies in malnourished, community dwelling older persons.

A critical appraisal of nutritional intervention studies in malnourished, community dwelling older persons. Clin Nutr. 2015 Dec 29; Authors: de van der Schueren MA, Wijnhoven HA, Kruizenga HM, Visser M Abstract BACKGROUND & AIMS: With the rapidly increasing number of malnourished older persons in the community, this review aims to summarize the effects of nutritional […]

The assessment of met and unmet care needs in the oldest old with and without depression using the Camberwell Assessment of Need for the Elderly (CANE): Results of the AgeMooDe study.

The assessment of met and unmet care needs in the oldest old with and without depression using the Camberwell Assessment of Need for the Elderly (CANE): Results of the AgeMooDe study. J Affect Disord. 2016 Jan 5;193:309-317 Authors: Stein J, Pabst A, Weyerer S, Werle J, Maier W, Heilmann K, Scherer M, Stark A, Kaduszkiewicz […]

Impact of functional and structural social relationships on two year depression outcomes: A multivariate analysis.

Impact of functional and structural social relationships on two year depression outcomes: A multivariate analysis. J Affect Disord. 2016 Jan 7;193:274-281 Authors: Davidson SK, Dowrick CF, Gunn JM Abstract BACKGROUND: High rates of persistent depression highlight the need to identify the risk factors associated with poor depression outcomes and to provide targeted interventions to people […]

Unmet reproductive health needs among women in some West African countries: a systematic review of outcome measures and determinants.

Unmet reproductive health needs among women in some West African countries: a systematic review of outcome measures and determinants. Reprod Health. 2016;13(1):5 Authors: Ayanore MA, Pavlova M, Groot W Abstract BACKGROUND: Identifying relevant measures of women’s reproductive health needs is critical to improve women’s chances of service utilization. The study aims to systematically review and […]

The effectiveness of bariatric surgery on long term psychosocial quality of life – A systematic review.

The effectiveness of bariatric surgery on long term psychosocial quality of life – A systematic review. Obes Res Clin Pract. 2016 Jan 7; Authors: Jumbe S, Bartlett C, Jumbe SL, Meyrick J Abstract BACKGROUND: Little is known about the psychological effects of bariatric surgery. This review aimed to assess long term effectiveness of bariatric surgery […]

A Prospective Cohort Study to Examine the Association Between Dietary Patterns and Sarcopenia in Chinese Community-Dwelling Older People in Hong Kong.

A Prospective Cohort Study to Examine the Association Between Dietary Patterns and Sarcopenia in Chinese Community-Dwelling Older People in Hong Kong. J Am Med Dir Assoc. 2016 Jan 13; Authors: Chan R, Leung J, Woo J Abstract OBJECTIVES: Dietary pattern analysis has recently emerged as an alternative approach to investigate the association between diet and […]

Il lipofilling al terzo posto tra le procedure Soft Cod: 871

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
IL LIPOFILLING DEL SENO E GLUTEI A PERUGIA Il lipofilling è una procedura naturale e sicura che permette di ridefinire alcune zone del corpo come il seno e i glutei. L’International Society of Aesthetic Plastic Surgery Associazione di chirurghi Plastici nel mondo , ci informa che il Lipofilling si colloca al 3° posto tra le… Continue reading Il lipofilling al terzo posto tra le procedure Soft Cod: 871

The Last Dalai Lama? – New York Times

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
New York Times The Last Dalai Lama? New York Times Not long after, giant posters of Mao Zedong appeared in front of the Potala Palace in Lhasa, the seat of the Dalai Lama, traditionally the most powerful leader of the Gelugpa order of Tibetan Buddhism and the spiritual and temporal leader of Tibet … and… Continue reading The Last Dalai Lama? – New York Times

WHAT’S UP DOC? What is the treatment for thyroid cancer? – Wicked Local Ipswich

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Wicked Local Ipswich WHAT’S UP DOC? What is the treatment for thyroid cancer? Wicked Local Ipswich Q: My friend was diagnosed with thyroid cancer and has to get radioactive iodine treatment. What can you tell me about this? A: The thyroid is a butterfly-shaped gland in the front of the lower neck which makes thyroid… Continue reading WHAT’S UP DOC? What is the treatment for thyroid cancer? – Wicked Local Ipswich

Study shows less physically mature ice hockey players have prolonged concussion symptoms

A study led by a Hasbro Children’s Hospital sports medicine physician found that male student ice hockey players in earlier pubertal stages had a significantly increased risk of prolonged symptoms… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PB1FCF via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros […]

Trends in colorectal cancer in the elderly in Denmark, 1980-2012.

Conclusion The incidence of CRC is increasing, especially in older citizens, and mortality increases with older age. There is limited knowledge on how to optimize treatment in older CRC patients and future focus must be how to select and tailor the treatment for older CRC patients. PMID: 26765865 [PubMed – as supplied by publisher] (Source: […]

Trends in upper gastro-intestinal cancer among the elderly in Denmark, 1980-2012.

Conclusion There is a need for clinical trials focusing on patients over the age of 70 years with co-existing comorbidity. PMID: 26765771 [PubMed – as supplied by publisher] (Source: Acta Oncologica) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RvLBbi via IFTTT

USPIO-enhanced 3D-cine self-gated cardiac MRI based on a stack-of-stars golden angle short echo time sequence: Application on mice with acute myocardial infarction

Purpose To develop and assess a 3D-cine self-gated method for cardiac imaging of murine models. Materials and Methods A 3D stack-of-stars (SOS) short echo time (STE) sequence with a navigator echo was performed at 7T on healthy mice (n = 4) and mice with acute myocardial infarction (MI) (n = 4) injected with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles. […]

Diagnostic quality assessment of compressed sensing accelerated magnetic resonance neuroimaging

Purpose To determine the efficacy of compressed sensing (CS) reconstructions for specific clinical magnetic resonance neuroimaging applications beyond more conventional acceleration techniques such as parallel imaging (PI) and low-resolution acquisitions. Materials and Methods Raw k-space data were acquired from five healthy volunteers on a 3T scanner using a 32-channel head coil using T2-FLAIR, FIESTA-C, time […]

Trends in cancer of the head and neck in the elderly in Denmark, 1980-2012.

Conclusion HNSCC is a rare disease in patients above 70 years accounting for only 17% of all HNSCC patients. Incidence rates increased over time, but age-specific survival rates improved, especially in younger patients. Failure rates to comply with radiation treatment, however, were low in both young and elderly patients. PMID: 26760291 [PubMed – as supplied […]

Diffusion-Weighted imaging and diffusion tensor imaging detect delayed graft function and correlate with allograft fibrosis in patients early after kidney transplantation

Purpose To combine diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) for detection of allograft dysfunction in patients early after kidney transplantation and to correlate diffusion parameters with renal function and renal histology of allograft biopsies. Materials and Methods Between day 4 and 11 after kidney transplantation 33 patients with initial graft function and 31 […]

Tuberculosis reactivation in a patient receiving anti-programmed death-1 (PD-1) inhibitor for relapsed Hodgkin’s lymphoma.

Authors: Lee JJ, Chan A, Tang T PMID: 26754959 [PubMed – as supplied by publisher] (Source: Acta Oncologica) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RvLzAr via IFTTT

Use of texture analysis based on contrast-enhanced MRI to predict treatment response to chemoradiotherapy in nasopharyngeal carcinoma

Purpose To explore the clinical potential of texture analysis using contrast-enhanced 3.0T magnetic resonance imaging (MRI) for predicting the therapeutic response of nasopharyngeal carcinoma (NPC) to chemoradiotherapy. Materials and Methods The dataset comprised pretreatment T1-, T2-, and diffusion-weighted MR images from 53 eligible patients with newly diagnosed NPC. The patients were divided into two sets: […]

The effect of training during treatment with chemotherapy on muscle strength and endurance capacity: A systematic review.

Conclusions This review indicates that training during chemotherapy may help in preventing the decrease in muscle strength and endurance capacity. It is important to know which training intensity and duration is the most effective in training cancer patients, to provide a training program suitable for every cancer patient. Training should be based on good research […]

7T MRI in focal epilepsy with unrevealing conventional field strength imaging

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Summary Objective To assess the diagnostic yield of 7T magnetic resonance imaging (MRI) in detecting and characterizing structural lesions in patients with intractable focal epilepsy and unrevealing conventional (1.5 or 3T) MRI. Methods We conducted an observational clinical imaging study on 21 patients (17 adults and 4 children) with intractable focal epilepsy, exhibiting clinical and electroencephalographic features consistent with a single seizure-onset zone (SOZ) and unrevealing conventional MRI. Patients were enrolled at two tertiary epilepsy surgery centers and imaged at 7T... περισσότερα »

Συνέντευξη Τύπου με θέμα «Νεότερες εξελίξεις στο χώρο της καρδιοαγγειακής ιατρικής»

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
*Συνέντευξη Τύπου* με θέμα «*Νεότερες εξελίξεις στο χώρο της καρδιοαγγειακής ιατρικής»* Ομιλητές : - *Παναγιώτης Βάρδας*, Καθηγητής Καρδιολογίας Πανεπιστημίου Κρήτης και πρώην Πρόεδρος της Ευρωπαϊκής Καρδιολογικής Εταιρείας - *Κωνσταντίνος Βέμμος*, Παθολόγος , τ. Διευθυντής ΕΣΥ (Υπεύθυνος Μονάδας Οξέων Αγγειακών Εγκεφαλικών Επεισοδίων Νοσοκομείο "Αλεξάνδρα") Η Συνέντευξη Τύπου θα πραγματοποιηθεί την *Τρίτη 19 Ιανουαρίου 2016* στο *Divani Caravel**, Αίθουσα* *Athens View* και ώρα *12:00.* * Invitation Heart Vessels & Stroke 190216* from Neurology via ...περισσότερα »

Frailty in Geriatric Glioblastoma Patients: A Predictor of Operative Morbidity and Outcome.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Frailty in Geriatric Glioblastoma Patients: A Predictor of Operative Morbidity and Outcome.* World Neurosurg. 2016 Jan 13; Authors: Cloney M, D'Amico R, Lebovic J, Nazarian M, Zacharia BE, Sisti MB, Bruce JN, McKhann GM, Iwamoto FM, Sonabend AM Abstract INTRODUCTION: Frailty is an emerging means of assessing overall health status and guiding management for geriatric patients. Frailty is associated with outcomes for many surgical indications in this age group. While half of all glioblastoma patients are 65 years old or older, frailty has not been examined in relation to surgery ... περισσότερα »

Management of subarachnoid hemorrhage in two important Italian political leaders: a paradigm of ethical and technological evolution of neurosurgery during the past half-century.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Management of subarachnoid hemorrhage in two important Italian political leaders: a paradigm of ethical and technological evolution of neurosurgery during the past half-century.* World Neurosurg. 2016 Jan 13; Authors: Longatti P, Giombelli E, Pavesi G, Carteri A, Feletti A Abstract For a curious and extraordinary coincidence, 5 out of 7 most relevant leaders of the Italian Communist Party (Partito Comunista Italiano, PCI, which was established in 1921, has been the biggest Communist Party in Western Countries) suffered a cerebral stroke. Cerebrovascular diseases afflicted also ... περισσότερα »

Use of texture analysis based on contrast-enhanced MRI to predict treatment response to chemoradiotherapy in nasopharyngeal carcinoma

Purpose To explore the clinical potential of texture analysis using contrast-enhanced 3.0T magnetic resonance imaging (MRI) for predicting the therapeutic response of nasopharyngeal carcinoma (NPC) to chemoradiotherapy. Materials and Methods The dataset comprised pretreatment T1-, T2-, and diffusion-weighted MR images from 53 eligible patients with newly diagnosed NPC. The patients were divided into two sets: […]

Design of an FMCW radar baseband signal processing system for automotive application

For a typical FMCW automotive radar system, a new design of baseband signal processing architecture and algorithms is proposed to overcome the ghost targets and overlapping problems in the multi-target detection scenario. To satisfy the short measurement time constraint without increasing the RF front-end loading, a three-segment waveform with different slopes is utilized. By introducing […]

How Should We Consider the Risk of Antineutrophil Cytoplasmic Antibody (ANCA)–Positive Small-Vessel Vascul itis Associated with Antithyroid Drug Therapy?

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
How Should We Consider the Risk of Antineutrophil Cytoplasmic Antibody (ANCA)–Positive Small-Vessel Vasculitis Associated with Antithyroid Drug Therapy?: Clinical Thyroidology Jan 2016, Vol. 28, No. 1: 18-21. - Full Text HTML - Full Text PDF (223.4 KB) - Full Text PDF with Links (225.7 KB) Author information Jacques Orgiazzi Balavoine AS, Glinoer D, Dubucquoi S, Wémeau JL. Antineutrophil cytoplasmic antibody-positive small-vessel vasculitis associated with antithyroid drug therapy: how significant is the clinical problem? Thyroid 2015;25:1273-81. Epub October 19 2015.... περισσότερα »

Physiological and pathological impact of exosomes of adipose tissue

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Abstract Exosomes are nanovesicles that have emerged as a new intercellular communication system for transporting proteins and RNAs; recent studies have shown that they play a role in many physiological and pathological processes such as immune regulation, cell differentiation, infection and cancer. By transferring proteins, mRNAs and microRNAs, exosomes act as information vehicles that alter the behavior of recipient cells. Compared to direct cell-cell contact or secreted factors, exosomes can affect recipient cells in more efficient ways. In whole adipose tissues, it has been sh... περισσότερα »

Open-book Splitting of a Distally Based Peroneus Brevis Muscle Flap to Cover Large Leg and Ankle Defects

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
[image: image]Background: Large soft-tissue defects in the lower leg and ankle are a major problem for plastic surgeons. Many local flaps that are either proximally or distally based have been previously described to cover small defects. Larger defects may require a distant flap that is either pedicled or free. The peroneus brevis muscle flap is a well-known distally based safe flap that is used to cover a small defect. Methods: Ten distally based peroneus brevis muscle flaps were elevated in 10 patients (8 males and 2 females) with major lower third leg and ankle defects that were... περισσότερα »

Development of a novel kinetic model for the analysis of PAH biodegradation in the presence of lead and cadmium co-contaminants.

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Publication date: 15 April 2016 *Source:*Journal of Hazardous Materials, Volume 307 Author(s): Michael E. Deary, Chinedu C. Ekumankama, Stephen P. Cummings We report on the results of a 40 week study in which the biodegradation of 16 US EPA polycyclic aromatic hydrocarbons (PAHs) was followed in microcosms containing soil of high organic carbon content (11%) in the presence and absence of lead and cadmium co-contaminants. The total spiked PAH concentration was 2166mg/kg. Mercury amendment was also made to give an abiotic control.A novel kinetic model has been developed to explain the... περισσότερα »

Mechanism of Aloe Vera extract protection against UVA: shelter of lysosomal membrane avoids photodamage

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
*Photochem. Photobiol. Sci.*, 2016, Accepted Manuscript *DOI*: 10.1039/C5PP00409H, Paper Daniela Rodrigues, Ana Claudia Viotto, Robert G Checchia, Andreza Barbosa Gomide, Rosangela Itri, Divinomar Severino, Mauricio S. Baptista, Waleska Kerllen Martins The premature aging (photoaging) of skin characterized by wrinkles, leathery texture and mottled pigmentation is a well-documented consequence of exposure to sunlight. UVA is an important risk factor for human… The content of this RSS Feed (c) The Royal Society of Chemistry [image: 1QhwMrF] from #Head and Neck by Sfakianakis via simera... περισσότερα »

Accuracy of instructor assessment of chest compression quality during simulated resuscitation

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Research Articles Erin E. Brennan, Robert C. McGraw, Steven C. Brooks Canadian Journal of Emergency Medicine, FirstView Article(s), 7 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1U6uGdu via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ROZuBS via IFTTT

Suitability of hair type for dermatophytes perforation and differential diagnosis of T. mentagrophytes from T. verrucosum

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Summary Most of the dermatophyte species have the ability to perforate hair structure and consume its contents of keratin through secretion of keratinase enzyme. Two clinical isolated species of dermatophytes were diagnosed as *Trichophyton mentagrophytes* var. *granulosum* and *Trichophyton verrucosum*. To determine the perforation ability, the isolated fungi were incubated with the hair of four different animals (rabbit, rat, cow and cat) and human hairs with three different colours (black, albino and bleached yellow) for different periods. Variable perforating ability of *T. me... περισσότερα »

Two-fold illumination in topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) for superficial basal cell carcinoma (sBCC): A retrospective case series and cohort study.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Two-fold illumination in topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) for superficial basal cell carcinoma (sBCC): A retrospective case series and cohort study.* J Am Acad Dermatol. 2016 Jan 13; Authors: Kessels J, Hendriks J, Nelemans P, Mosterd K, Kelleners-Smeets N Abstract BACKGROUND: There is limited literature on efficacy using a 2-fold illumination scheme in aminolevulinic acid (ALA) photodynamic therapy for superficial basal cell carcinoma (sBCC). OBJECTIVES: We sought to determine the efficacy of ALA photodynamic therapy for sBCC using a 2-fol...περισσότερα »

Thyroid compressive mass, a metastasis of femur chondrosarcoma after 14 years: case report and literature review.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Thyroid compressive mass, a metastasis of femur chondrosarcoma after 14 years: case report and literature review.* Braz J Otorhinolaryngol. 2015 Dec 18; Authors: Simon F, Classe M, Vironneau P, Wassef M, Herman P, Le Clerc N PMID: 26774495 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/209qtt7 via IFTTT

Gold Bars/Dusts

Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 2 ώρες
Hello Sir, I am the Sales Director of local mining organization here in Ghana, we are registered private miners under the mineral commission of Ghana. I am also acting as an agent for companies in the mining field and I wish to write and open up this proposal to you. I serve the interest of (4) four licensed small -scale GOLD mining companies by imparting to them expertise in modern techniques of mining. In return, I collect their gold for proper marketing in the international market. Currently, I have the quantity of 370 kg [Au] Gold Bars of 22+ carats with 92% purity that I can sale to... περισσότερα »

Treatment of lipoid proteinosis with acitretin in two patients from two unrelated Chinese families with novel nonsense mutations of the ECM1 gene

Abstract Lipoid proteinosis is a rare recessive genetic disorder caused by loss-of-function mutations to chromosome 1 at 1q21, the extracellular matrix protein 1 (ECM1) gene. Two children with lipoid proteinosis were reported from two unrelated Chinese families, both manifesting with a typical hoarse voice, white acne-like atrophic lesions and scarring on the skin, and beaded […]

Keratotic condyloma acuminatum

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Water-based correction fluid is a useful skin marker for determination of the tumor margin of basal cell carcinoma under high-frequency ultrasound

Abstract We propose a new method to determine the appropriate preoperative surgical margin of basal cell carcinoma (BCC) by using water-based correction fluid as a skin marker showing the tumor position on the skin under high-frequency ultrasound (HFUS). After a provisional evaluation by dermoscopy, an approximately 2-mm dot of water-based correction fluid is applied to […]

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