Indications for open procedures in the endoscopic era
Indications for open procedures in the endoscopic era. by Konstantinidis, Iordanis; Constantinidis, Jannis via Current Opinion in Otolaryngology & Head and Neck Surgery - Published Ahead-of-Print Purpose of review: Endoscopic sinus surgery became the gold standard in inflammatory disorders of the nose and paranasal sinuses, in cerebrospinal fluid leak and epistaxis management, and established its efficacy in the oncology of the region. However, there are certain limitations which make an external approach mandatory. This article reviews the recent literature describing the cases where...περισσότερα »
Endoscopic repair of cerebrospinal fluid rhinorrhoea
Endoscopic repair of cerebrospinal fluid rhinorrhoea via European Annals of Otorhinolaryngology, Head and Neck Diseases *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): S.D. Sharma, G. Kumar, J. Bal, A. Eweiss GoalThe purpose of this review was to look at the success rate of transnasal endoscopic repair of CSF rhinorrhoea and the impact of patient factors, repair techniques and adjuvant treatment.Material and methodsA literature search was performed on PubMed, Medline and Cochrane Central databases, independently by two of the authors, of all studies ...περισσότερα »
Office-based Rhinology
New innovations in office-based rhinology. by Varshney, Rickul; Lee, Jivianne T. via Current Opinion in Otolaryngology & Head and Neck Surgery - Published Ahead-of-Print Purpose of review: Chronic rhinosinusitis (CRS) affects millions of patients worldwide, with significant health and financial implications. There is an immense utilization of resources involved, including prescription medications and surgical interventions. With increased emphasis on sound resource allocation and patient convenience, recent years have witnessed significant expansion in office-based rhinologic procedur... περισσότερα »
European Annals of Otorhinolaryngology, Head and Neck Diseases
Endoscopic repair of cerebrospinal fluid rhinorrhoea Publication date: Available online 6 January 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): S.D. Sharma, G. Kumar, J. Bal, A. Eweiss Goal The purpose of this review was to look at the success rate of transnasal endoscopic repair of CSF rhinorrhoea and the impact of patient factors, repair techniques and adjuvant treatment. Material and methods A literature search was performed on PubMed, Medline and Cochrane Central databases, independently by two of the authors, of all studies reporting the...περισσότερα »
Laryngeal Rhinoscleroma
A case of laryngeal rhinoscleroma via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 5 January 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): Y. Gobel, G. Valette, L. Delahaye, R. Marianowski [image: Laryngeal endoscopy showing the subglottic rhinoscleroma lesion (A).] [image: Computed tomography, axial scan, showing the circumferential subglottic ...]
Multi-pollutant surface objective analyses and mapping of air quality health index over North America
Abstract Air quality, like weather, can affect everyone, but responses differ depending on the sensitivity and health condition of a given individual. To help protect exposed populations, many countries have put in place real-time air quality nowcasting and forecasting capabilities. We present in this paper an optimal combination of air quality measurements and model outputs… Continue reading Multi-pollutant surface objective analyses and mapping of air quality health index over North America
Temperature-controlled laminar airflow in severe asthma for exacerbation reduction (The LASER Trial): study protocol for a randomised controlled trial
Abstract Background Asthma affects more than 5 million patients in the United Kingdom. Nearly 500,000 of these patients have severe asthma with severe symptoms and frequent exacerbations that are inadequately controlled with available treatments. The burden of severe asthma on the NHS is enormous, accounting for 80 % of the total asthma cost (£1 billion),… Continue reading Temperature-controlled laminar airflow in severe asthma for exacerbation reduction (The LASER Trial): study protocol for a randomised controlled trial
Sidt2 is involved in the NAADP-mediated release of calcium from insulin secretory granules
The Sidt2 global knockout mouse Sidt2–/– has impaired insulin secretion. The aim of this study was to assess the role of Sidt2 protein in glucose-induced insulin secretion in primary cultured mouse β-cells. The major metabolic and electrophysiological steps of glucose-induced insulin secretion of primary cultured β-cells from Sidt2–/– mice were investigated. The β-cells from Sidt2–/–… Continue reading Sidt2 is involved in the NAADP-mediated release of calcium from insulin secretory granules
Turning Cancer Cells into Cancer Killers News in Brief
Researchers have changed leukemia cells into natural killer cells by adding a specific antibody to bone marrow cells from patients with acute myeloblastic leukemia. The induced natural killer cells killed leukemia cells in culture. The antibody does not trigger the same conversion in bone marrow from healthy patients. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Rnt0P9… Continue reading Turning Cancer Cells into Cancer Killers News in Brief
Olaparib Targets Some Advanced Prostate Cancers News in Brief
In the phase II TOPARP-A clinical trial, patients with metastatic castrate-resistant prostate cancer who were treated with the PARP inhibitor olaparib lived nearly three times longer without their cancer worsening if their tumors had mutations in at least one of 12 DNA repair genes. However, physicians say that a larger trial is needed to confirm… Continue reading Olaparib Targets Some Advanced Prostate Cancers News in Brief
Brain May Prime Metastatic Cell Growth News in Brief
Metastasizing tumor cells lose expression of the tumor suppressor PTEN at a much higher rate when they enter the brain compared to other organs, suggesting that the brain’s unique microenvironment may prime metastatic cells for aggressive growth, a recent study reports. The findings may have implications for developing targeted therapies for brain metastases. from #Medicine-SfakianakisAlexandros… Continue reading Brain May Prime Metastatic Cell Growth News in Brief
PF-06463922 Overcomes Primary Resistance in Neuroblastoma Research Articles
Neuroblastomas harboring activating point mutations in anaplastic lymphoma kinase (ALK) are differentially sensitive to the ALK inhibitor crizotinib, with certain mutations conferring intrinsic crizotinib resistance. To overcome this clinical obstacle, our goal was to identify inhibitors with improved potency that can target intractable ALK variants such as F1174L. We find that PF-06463922 has high potency… Continue reading PF-06463922 Overcomes Primary Resistance in Neuroblastoma Research Articles
The Nuclear Lamina Protein Lamin B1 Is a Selective Autophagy Substrate Autophagy
Selective autophagy degrades lamin B1 in response to oncogenic and genotoxic insults. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Rnt0OX via IFTTT
Targeting the Ribosome to Treat MYC-Driven Lymphoma Research Briefs
Ribosome biogenesis and protein synthesis are dysregulated in many cancers, with those driven by the proto-oncogene c-MYC characterized by elevated Pol I–mediated ribosomal rDNA transcription and mTORC1/eIF4E-driven mRNA translation. Here, we demonstrate that coordinated targeting of rDNA transcription and PI3K–AKT–mTORC1-dependent ribosome biogenesis and protein synthesis provides a remarkable improvement in survival in MYC-driven B lymphoma.… Continue reading Targeting the Ribosome to Treat MYC-Driven Lymphoma Research Briefs
TRK Inhibitor Shows Early Promise News in Brief
Results from a phase I study show that the TRK inhibitor LOXO-101 is well tolerated and effective, with patients whose tumors bear NTRK fusions responding well and durably to this targeted therapy. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Rnt0yy via IFTTT
Reconstruction of lateral defects of the tip and supratip less than 1.5cm in diameter
Reconstruction of lateral defects of the tip and supratip less than 1.5cm in diameter via European Annals of Otorhinolaryngology, Head and Neck Diseases *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): M. Durbec, F. Disant The authors describe the surgical technique as well as the indications and limitations of the East-West flap for repair of lateral defects of the tip/supratip of the nose less than 1.5cm in diameter. This easy and reliable technique is based on the use of skin from the lower third of the nose to repair the defect. This tissue prese... περισσότερα »
Combination Chemotherapy in Treating Patients With Advanced Esophageal Cancer
Combination Chemotherapy in Treating Patients With Advanced Stomach, Gastroesophageal, or Esophageal Cancer: *Conditions*: Stomach Neoplasms; Esophageal Neoplasms *Interventions*: Drug: Irinotecan; Drug: Trastuzumab; Drug: Oxaliplatin; Drug: Leucovorin; Drug: Fluorouracil *Sponsor*: Washington University School of Medicine This phase II trial studies how well combination chemotherapy works in treating patients with advanced stomach, gastroesophageal, or esophageal cancer. Drugs used in chemotherapy, such as irinotecan hydrochloride, oxaliplatin, leucovorin calcium...περισσότερα »
Mitomycin C in Patients With Incurable p16 Positive Oropharyngeal and p16 Negative Head and Neck Squamous Cell Carcinoma (HNSCC) Resistant to Platin, 5-FU, Cetuximab, and Taxane
Mitomycin C in Patients With Incurable p16 Positive Oropharyngeal and p16 Negative Head and Neck Squamous Cell Carcinoma (HNSCC) Resistant to Platin, 5-FU, Cetuximab, and Taxane: *Conditions*: Squamous Cell Carcinoma of the Head and Neck; Squamous Cell Carcinoma, Head and Neck *Interventions*: Drug: Mitomycin-C; Drug: Pegfilgrastim *Sponsor*: Washington University School of Medicine No agent is known to have efficacy in patients with incurable HNSCC that progressed with prior platin, 5-FU, cetuximab and taxane. Herein lies the unmet need to be addressed by this trial. ...περισσότερα »
Huachansu Plus Thoracic RT Versus RT Alone For ESCC
A Study of Comparing Huachansu Plus Thoracic RT Versus RT Alone For ESCC: *Condition*: Esophageal Squamous Cell Carcinoma *Interventions*: Drug: Huachansu; Radiation: thoracic radiation *Sponsor*: Fudan University [image: Bufo periglenes2.jpg] HuaChanSu From Wikipedia, the free encyclopedia *HuaChanSu* (bufo bufo gargarizans) is a traditional Chinese medicine extracted from the skin of the Bufo toad that is believed by some to slow the spread of cancerous cells.[1] The skin of the Bufo toad secretes a venom which is dried and dissolved in water. This solution, HuaChanSu, i... περισσότερα »
Influence of the breathing pattern on the learning process
: a systematic review of literature via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 7 January 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Genef Caroline Andrade Ribeiro, Isadora Diniz dos Santos, Ana Claudia Nascimento Santos, Luiz Renato Paranhos, Carla Patrícia Hernandez Alves Ribeiro César IntroductionMouth breathing has negative consequences for quality of life, especially for children in school.ObjectiveTo determine whether the breathing pattern influences children's learning process.MethodsThis syste...περισσότερα »
Nasal obstruction on sleep apnea
Systematic review: the influence of nasal obstruction on sleep apnea via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 7 January 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Debora Petrungaro Migueis, Luiz Claudio Santos Thuler, Lucas Neves de Andrade Lemes, Chirlene Santos Souza Moreira, Lucia Joffily, Maria Helena de Araujo-Melo IntroductionObstructive sleep apnea syndrome (OSAS) is a common disorder that can lead to cardiovascular morbidity and mortality, as well as to metabolic, neurological, and behaviora... περισσότερα »
Nerve combing and percutaneous radiofrequency thermocoagulation in the treatment for idiopathic trigeminal neuralgia
Comparison of via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 7 January 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Xuanchen Zhou, Yiqing Liu, Zhiyong Yue, Deheng Luan, Hong Zhang, Jie Han IntroductionIdiopathic trigeminal neuralgia (ITN) is a common pain disease in elderly people. Many methods have been used to alleviate the pain of patients, but few studies in the literature have compared the effect of nerve combing and percutaneous radiofrequency thermocoagulation.ObjectiveThe purpose of this study was... περισσότερα »
Acute laryngeal lesions in children undergoing endotracheal intubation
Incidence and endoscopic characteristics of via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 7 January 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Eliandra da Silveira de Lima, Maíra Alves Braga de Oliveira, Carolina Rocha Barone, Kharina Mayara Moreira Dias, Samanta Daiana De Rossi, Claudia Schweiger, Denise Manica, Larissa Valency Enéas, Catia de Souza Saleh Netto, Gabriel Kuhl, Paulo Roberto Antonacci Carvalho, Paulo Jose Cauduro Marostica IntroductionAcute laryngeal lesions after intubation appear to be... περισσότερα »
The influence of growth factors on skin wound healing
in rats via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 7 January 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Elen Carolina David João de Masi, Antonio Carlos Ligocki Campos, Flavia David João de Masi, Marco Aurelio Soatti Ratti, Isabela Shin Ike, Roberta David João de Mais IntroductionHealing is a process that restores the physical integrity of body structures. It is a dynamic, complex, multicellular process that involves the extracellular matrix, cytokines, blood cells, and growth factors. Growth factor...περισσότερα »
Evaluation of Appeal and Impact of E-Cigarettes Among Chronic Smokers With Smoking-Related Cancers
Evaluation of Appeal and Impact of E-Cigarettes Among Chronic Smokers With Smoking-Related Cancers: *Conditions*: Nicotine Dependence, Other Tobacco Product; Bladder Cancer; Lung Cancer; Cancer of Head and Neck *Intervention*: Device: HALO *Sponsor*: Dartmouth-Hitchcock Medical Center ArmsAssigned InterventionsActive Comparator: HALO G6 HALO cigalike model Device: HALO HALO manufactures e-cigarettes which will be distributed to patients. Two products, the G6 and tank model will be used. Active Comparator: HALO Triton HALO tank model Device: HALO HALO manufactures e-... περισσότερα »
Huffing is the inhalation of chemicals to get high : How huffing causes respiratory arrest
Remember 2 Things: How huffing causes respiratory arrest: Huffing is the inhalation of chemicals to get high. Learn two important things about assessment and treatment of a patient known to or suspected to have huffed chemicals.
Sinusitis and oroantral fistula in patients with bisphosphonate-associated necrosis of the maxilla
*Sinusitis and oroantral fistula in patients with bisphosphonate-associated necrosis of the maxilla: * Abstract Background*The management of bisphosphonate related necrosis of the jaw has become clinical routine. While approximately two thirds of the lesions are in the mandible, one third is located in the maxilla. In 40–50 % of maxillary necrosis the maxillary sinus is involved, leading to maxillary sinusitis and oro-antral communications.* Methods*This retrospective single center study includes all patients with diagnosis of BP-ONJ of the maxilla and concomitant maxillary sinu... περισσότερα »
Evaluation of resident’s training for endoscopic sinus surgery using a sheep’s head
*Evaluation of resident’s training for endoscopic sinus surgery using a sheep’s head: * Abstract*Training in functional endoscopic sinus surgery (FESS) is an essential part of each ENT resident and it takes place on a very fragile area. This study focus on showing the learning curve of FESS, using an anatomical model such as the sheep's head. Four residents in our centre performed dissections. Each of these residents operated eight sheep's head. They performed an endoscopic septoplasty followed by maxillary antrostomy, total ethmoidectomy and frontal sinusotomy on every head. A staf...περισσότερα »
Dysphagia in HPV-positive oropharyngeal cancer receiving chemo-irradiation or cetuximab-irradiation
Comparisons of dysphagia and quality of life (QOL) in comparable patients with HPV-positive oropharyngeal cancer receiving chemo-irradiation or cetuximab-irradiation via ScienceDirect Publication: Oral Oncology Publication date: Available online 6 January 2016 *Source:*Oral Oncology Author(s): Stuart E. Samuels, Yebin Tao, Teresa Lyden, Marc Haxer, Matthew Spector, Kelly M. Malloy, Mark E. Prince, Carol R. Bradford, Francis P. Worden, Matthew Schipper, Avraham Eisbruch PurposeCompare functional outcomes of radiotherapy (RT) concurrent with cetuximab (cet-RT) or with chemotherapy (chemo... περισσότερα »
Use of Conchal Cartilages for Laryngotracheal Stenosis: Experiences at a Tertiary Care Hospital of Eastern India
*Use of Conchal Cartilages for Laryngotracheal Stenosis: Experiences at a Tertiary Care Hospital of Eastern India: * Abstract*To describe the experience of anterior cricotracheal split with insertion of conchal cartilage graft in the treatment of subglottic and tracheal stenosis at a tertiary care hospital of eastern India. Six patients were included in the study, in the age group of 20–48 years. Out of which five patients were successfully decannulated after 3 months of laryngotracheal reconstruction with help of conchal cartilage. One case was undergone resection anastomosis after... περισσότερα »
Tympanoplasty—conchal cavum approach
Tympanoplasty—conchal cavum approach via Latest Results for Journal of Otolaryngology - Head & Neck Surgery AbstractᅟThe three well recognized tympanoplasty approaches: permeatal, postaural, and endaural, each have advantages and disadvantages. The permeatal approach is suitable only for ears with adequate canal size. The postaural approach limits visualization of the posterior eardrum margin. The endaural approach limits the view of the eardrum's anterior margin. This study describes a modified endaural approach, developed to overcome these limitations. A retrospective case series re... περισσότερα »
Updates in anterior skull base reconstruction
Updates in anterior skull base reconstruction by Zuniga, M. Geraldine; Turner, Justin H.; Chandra, Rakesh K. via Current Opinion in Otolaryngology & Head and Neck Surgery - Current Issue [image: image] Purpose of review: This article summarizes the indications and surgical techniques for the reconstructions of anterior skull base defects. Recent findings: There is increasing popularity of the vascularized pedicled flaps in endoscopic skull base surgery for the successful reconstruction of anterior skull base defects, compared with the use of free-tissue grafts. The location and size o...περισσότερα »
Innovations in nasal valve surgery
Innovations in nasal valve surgery by Motamedi, Kevin K.; Stephan, Scott J.; Ries, William R. via Current Opinion in Otolaryngology & Head and Neck Surgery - Current Issue [image: image]Purpose of review: This article reviews current practices in nasal valve repair and highlights recent innovations in the medical literature. Recent findings: A surgeon's choice regarding a proper nasal valve repair technique depends heavily on the patient's site of obstruction. While classical maneuvers to improve the internal and external nasal valves have been employed for several decades, increasing...περισσότερα »
Contemporary management of esthesioneuroblastoma
Contemporary management of esthesioneuroblastoma by Schwartz, Joseph S.; Palmer, James N.; Adappa, Nithin D. via Current Opinion in Otolaryngology & Head and Neck Surgery - Current Issue [image: image]Purpose of review: This article provides a contemporary review of the management of esthesioneuroblastoma (ENB) within the context of recent surgical advancements, while highlighting the ongoing limitations and controversies surrounding this uncommon pathologic entity. Recent findings: Surgical management of ENB is continuously evolving with contemporary endoscopic approaches complementi... περισσότερα »
Benign lichenoid keratosis (BLK)
A case of benign lichenoid keratosis: *Amita Mhatre, Nitin Nadkarni, Sharmila Patil, Shweta Agarwal* Indian Journal of Dermatopathology and Diagnostic Dermatology 2015 2(2):49-51 Sir, Benign lichenoid keratosis (BLK) is a dermatologic lesion of unknown etiology that is often confused with benign cutaneous neoplasm. BLK may represent lymphocyte-mediated regression of preexisting lentigo or reticulated seborrheic keratosis. Histologically, it may show findings of lichen planus (LP). The diagnosis of this benign lesion is made by a combination of clinical features, dermatoscopy, ... περισσότερα »
Facial porokeratosis of Mibelli
Facial porokeratosis of Mibelli mimicking discoid lupus erythematosus in young female: *Mukunda Ranga Swaroop, Shravandanahalli Nagendrakumar Manas, Kuchangi Channabasavaprabhu Nischal, Haleuoor Borelingegowda Basavaraj, Belagola Dasevegowda Sathyanarayana, Periasamy Vasudevan* Indian Journal of Dermatopathology and Diagnostic Dermatology 2015 2(2):40-42 Sir, Porokeratosis represents a rare, benign, heterogeneous group of genodermatoses having abnormal keratinization, with an autosomal-dominant mode of inheritance. Porokeratosis of Mibelli (PM) was first described in 1893 by V... περισσότερα »
Solitary stony hard plaque over the scalp
Solitary stony hard plaque over the scalp in a young adult: A case report: *Mukunda Ranga Swaroop, Periasamy Vasudevan, Kuchangi C Nischal, Belagola D Sathyanarayana* Indian Journal of Dermatopathology and Diagnostic Dermatology 2015 2(2):43-45 Sir, Osteoma cutis (OC) is a rare and benign disease characterized by the formation of bone tissue in dermis and subcutaneous tissue. It presents in children and adults with a female preponderance. [1] It is classified as primary OC (15%) wherein bone tissue formation occurs in skin without any pre-existing lesions or is associated with... περισσότερα »
Paclitaxel Tumor Distribution after Bevacizumab
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
The antitumor activity of angiogenesis inhibitors is reinforced in combination with chemotherapy. It is debated whether this potentiation is related to a better drug delivery to the tumor due to the antiangiogenic effects on tumor vessel phenotype and functionality. We addressed this question by combining bevacizumab with paclitaxel on A2780-1A9 ovarian carcinoma and HT-29 colon […]
A Top1 Inhibitor Selectively Toxic for Certain NSCLC Cells
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
SW044248, identified through a screen for chemicals that are selectively toxic for non–small cell lung cancer (NSCLC) cell lines, was found to rapidly inhibit macromolecular synthesis in sensitive, but not in insensitive, cells. SW044248 killed approximately 15% of a panel of 74 NSCLC cell lines and was nontoxic to immortalized human bronchial cell lines. The […]
TGF{alpha}-EGFR Signaling in Acquired Resistance to Alectinib
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Alectinib is a highly selective ALK inhibitor and shows promising efficacy in non–small cell lung cancers (NSCLC) harboring the EML4-ALK gene rearrangement. The precise mechanism of acquired resistance to alectinib is not well defined. The purpose of this study was to clarify the mechanism of acquired resistance to alectinib in ALK-translocated lung cancer cells. We […]
Ang-(1-7) Inhibits Proliferation of NPC Cells
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Angiotensin-(1-7) [Ang-(1-7)] is an endogenous, heptapeptide hormone acting through the Mas receptor (MasR), with antiproliferative and antiangiogenic properties. Recent studies have shown that Ang-(1-7) has an antiproliferative action on lung adenocarcinoma cells and prostate cancer cells. In this study, we report that MasR levels were significantly upregulated in nasopharyngeal carcinoma (NPC) specimens and NPC cell […]
KillerRed-Based Oncolytic Photodynamic Therapy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Photodynamic therapy (PDT) is a minimally invasive antitumor therapy that eradicates tumor cells through a photosensitizer-mediated cytotoxic effect upon light irradiation. However, systemic administration of photosensitizer often makes it difficult to avoid a photosensitive adverse effect. The red fluorescent protein KillerRed generates reactive oxygen species (ROS) upon green light irradiation. Here, we show the therapeutic […]
Targeting High-Ploidy Breast Cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Increased ploidy is common in tumors but treatments for tumors with excess chromosome sets are not available. Here, we characterize high-ploidy breast cancers and identify potential anticancer compounds selective for the high-ploidy state. Among 354 human breast cancers, 10% have mean chromosome copy number exceeding 3, and this is most common in triple-negative and HER2-positive […]
Surrobody Simultaneously Activates DR4 and DR5 Receptors
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Death receptors of the TNF family are found on the surface of most cancer cells and their activation typically kills cancer cells through the stimulation of the extrinsic apoptotic pathway. The endogenous ligand for death receptors 4 and 5 (DR4 and DR5) is TNF-related apoptosis-inducing ligand, TRAIL (Apo2L). As most untransformed cells are not susceptible […]
Targeting Myeloma by Proteasome and XPO1 Inhibitor
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Exportin1 (XPO1; also known as chromosome maintenance region 1, or CRM1) controls nucleo-cytoplasmic transport of most tumor suppressors and is overexpressed in many cancers, including multiple myeloma, functionally impairing tumor suppressive function via target mislocalization. Selective inhibitor of nuclear export (SINE) compounds block XPO1-mediated nuclear escape by disrupting cargo protein binding, leading to retention of […]
Rocaglates and eIF4E Phosphorylation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Rocaglates are natural products that inhibit protein synthesis in eukaryotes and exhibit antineoplastic activity. In vitro biochemical assays, affinity chromatography experiments coupled with mass spectrometry analysis, and in vivo genetic screens have identified eukaryotic initiation factor (eIF) 4A as a direct molecular target of rocaglates. eIF4A is the RNA helicase subunit of eIF4F, a complex […]
ML264 Inhibits the Growth of Colorectal Cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Colorectal cancer is one of the leading causes of cancer mortality in Western civilization. Studies have shown that colorectal cancer arises as a consequence of the modification of genes that regulate important cellular functions. Deregulation of the WNT and RAS/MAPK/PI3K signaling pathways has been shown to be important in the early stages of colorectal cancer […]
Oral melanocytic nevi are localized developmental tissue malformations of nevus cells in the oral mucosa
Oral melanocytic nevi: Report of two cases with immunohistochemical elaboration of their probable origin and maturation: *Dipti Dutta, Venkatesh V Kamath, Komali Rajkumar* Indian Journal of Dermatopathology and Diagnostic Dermatology 2015 2(2):29-33 Oral melanocytic nevi are localized developmental tissue malformations of nevus cells in the oral mucosa. Relatively rare in occurrence compared to their dermal counterparts, considerable debate exists in the literature related to their origin, development and maturation, and their relationship to oral melanocytes.We report two case... περισσότερα »
Diagnostic Performance of Ultrasound Elastography for Detection of Thyroid Cancer
Diagnostic Performance of Ultrasound Elastography for Detection of Thyroid Cancer: *Conditions*: Elastography; Thyroid Nodule *Intervention*: *Sponsor*: Seoul St. Mary's Hospital For patients with thyroid gland nodule, fine-needle aspiration biopsy has been proved to be an efficient tool for thyroid cancer diagnosis. However, it is somewhat an invasive procedure and is subject to sampling and analysis uncertainties. Thus, improved, more reliable criteria for determining which nodule should be be aspirated are needed. Ultrasound elastography has been shown to be useful in... περισσότερα »
Validation of DNA Methylation Biomarkers for Oral Cancer Detection
*Validation of DNA Methylation Biomarkers for Oral Cancer Detection: Conditions: Oral Cancer; Recurrence* *Intervention: * *Sponsors: Taipei Veterans General Hospital, Taiwan; iStat Biomedical CO., Ltd.* *Publications:* *Wang SS, Smiraglia DJ, Wu YZ, Ghosh S, Rader JS, Cho KR, Bonfiglio TA, Nayar R, Plass C, Sherman ME. Identification of novel methylation markers in cervical cancer using restriction landmark genomic scanning. Cancer Res. 2008 Apr 1;68(7):2489-97. doi: 10.1158/0008-5472.CAN-07-3194.* *Sova P, Feng Q, Geiss G, Wood T, Strauss R, Rudolf V, Lieber A, Kiviat ...περισσότερα »
The Clinical Prognosis of Bilateral Central Lymph Node Dissection in the Patients With Unilateral Thyroid Papillary Carcinoma
Prospective Study on the Clinical Prognosis of Bilateral Central Lymph Node Dissection in the Patients With Unilateral Thyroid Papillary Carcinoma: *Condition*: Thyroid Papillary Carcinoma *Interventions*: Procedure: surgery：BCND（bilateral central lymph node dissection）; Procedure: surgery：UCND（unilateral central lymph node dissection） *Sponsor*: Fujian Medical University This study recruit the patients with unilateral papillary thyroid cancer before operation,the patients agree to enter the test,and divided into experimental and control group.experimental group patients ... περισσότερα »
An ADC for Triple-Negative Breast Cancer News in Brief
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
A phase II study indicates that sacituzumab govitecan (IMMU-132), a Trop-2–specific antibody linked to the irinotecan metabolite SN-38, prolongs the progression-free survival of patients with advanced triple-negative breast cancer. IMMU-132 is well tolerated, causing fewer and more manageable side effects than irinotecan. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UBebpK via IFTTT
Tissue glue in wound healing of neck dissection
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
The impact of tissue glue in wound healing of head and neck patients undergoing neck dissection: Abstract We investigated the impact of fibrin glue on postoperative drainage amount and duration in head and neck cancer patients who underwent neck dissection. This study was a prospective randomized controlled trial. Patients who were scheduled to undergo neck […]
Clock-Like Mutational Signatures Are Present in Human Cancers Mutations
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Two clock-like somatic mutational signatures were identified in a variety of human tumors. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RnsXD1 via IFTTT
A minimally invasive laryngeal pacemaker system
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Pre-clinical evaluation of a minimally invasive laryngeal pacemaker system in mini-pig: Abstract Microlaryngoscopic enlargement techniques have been the standard treatment for bilateral vocal fold paralysis (BVFP) for decades. Laryngeal pacing is a promising alternative treatment based on the electrostimulation of the posterior cricoarytenoid (PCA) muscle. This paper reports on the results of a pre-clinical study […]
4.5-mm-wide bone-anchored hearing implant
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Stability, survival, and tolerability of a 4.5-mm-wide bone-anchored hearing implant: 6-month data from a randomized controlled clinical trial: Abstract The objective of this study was to compare the stability, survival, and tolerability of 2 percutaneous osseointegrated titanium implants for bone conduction hearing: a 4.5-mm diameter implant (test) and a 3.75-mm diameter implant (control). Fifty-seven adult […]
The effective stimulating pulse for restoration of blink function in unilateral facial nerve paralysis rabbits, verified by a simple FES system
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
The effective stimulating pulse for restoration of blink function in unilateral facial nerve paralysis rabbits, verified by a simple FES system: Abstract The trains of 200 ms biphasic square pulses with the width of 9 ms delivered at 50 Hz were found to be the most suitable and effective mean as stimulation in FES system […]
Is endoscopic ear surgery an alternative to the modified Bondy technique for limited epitympanic cholesteatoma?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Is endoscopic ear surgery an alternative to the modified Bondy technique for limited epitympanic cholesteatoma?: Abstract The objective of this study is to evaluate the outcomes of the modified Bondy’s technique performed at our center and for limited epitympanic cholesteatomas and to debate the purported benefits of endoscopic surgery for the same indication. This is […]
Vestibular evoked myogenic potentials in patients with ankylosing spondylitis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Vestibular evoked myogenic potentials in patients with ankylosing spondylitis: Abstract Ankylosing spondylitis (AS) is a chronic systemic inflammatory disease with unknown etiology. Although sacroiliac joint involvement is the classic sign along with the formed immune mediators, it may result in immune-mediated inner ear disease and may cause damage to the audiovestibular system. Vestibular evoked myogenic […]
Caffeine on olfactory function
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Short-term effect of caffeine on olfactory function in hyposmic patients: Abstract The purpose of this study was to investigate the potential effects of caffeine in patients with olfactory loss. The suggested mechanisms of action consist in the non-selective blocking of adenosine receptors as well as inhibition of the phospodiesterase. Olfactory function was tested twice in […]
Early Diagnosis and Surgery is Crucial to Survival Outcome in Rhinocerebral Mucormycosis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Early Diagnosis and Surgery is Crucial to Survival Outcome in Rhinocerebral Mucormycosis: from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mH9AIc via IFTTT
Anlotinib in Patients With Esophageal Squamous Cell Carcinoma (ALTER1102)
Study of Anlotinib in Patients With Esophageal Squamous Cell Carcinoma (ALTER1102): *Condition*: Esophageal Squamous Cell Carcinoma *Interventions*: Drug: Anlotinib; Drug: Placebo *Sponsor*: Jiangsu Chia-tai Tianqing Pharmaceutical Co.,Ltd ArmsAssigned InterventionsExperimental: Anlotinib Anlotinib QD po and it should be continued until disease progression or intolerable toxicity or patients withdrawal of consent Drug: Anlotinib Anlotinib p.o. qd Placebo Comparator: Placebo Placebo QD po and it should be continued until disease progression or intolerable toxicity or patients... περισσότερα »
Classification of Cholesteatoma According to Growth Patterns
Classification of Cholesteatoma According to Growth Patterns: This cross-sectional comparative study of 414 ears classifies cholesteatomas into subtypes and describes their prevalence. *Importance* Several classifications of cholesteatoma exist, but there are controversies about their clinical application. *Objective* To classify cholesteatomas and describe the prevalence of the subtypes. *Design, Setting, and Participants* A cross-sectional comparative study of 414 ears in 356 consecutive patients with middle ear cholesteatoma and no history of ear surgery treated at a tertiar... περισσότερα »
Vascular Findings in the Cochlea in Patients With Presbycusis
Vascular Findings in the Cochlea in Patients With Presbycusis: This analysis of age-related histopathologic changes of the stria vascularis and vessels in the cochlea compares autopsy reports of temporal bones of patients with presbycusis and a control group with normal hearing. *Importance* Age-related changes in cochlear vessel wall thickness in human temporal bones have not been described previously. *Objectives* To compare thickness of the spiral modiolar artery and strial capillaries and to investigate strial atrophy and vessel loss in temporal bones with and without presby... περισσότερα »
A Patient With DNMT1 Gene Mutation : Hearing loss in patients with hereditary sensory and autonomic neuropathie type 1E
A Patient With DNMT1 Gene Mutation: This case report highlights the pattern of hearing loss in patients with hereditary sensory and autonomic neuropathie type 1E. [image: First page PDF preview]
Recurrent laryngeal nerve identification in thyroidectomy by intra-operative staining with methylene blue
Recurrent laryngeal nerve identification in thyroidectomy by intra-operative staining with methylene blue in 46 patients: Abstract - During total thyroidectomy in 46 patients (92 lobes), recurrent laryngeal nerve (RLN) was recognized on one side by visual identification alone, and on the other side combined with methylene blue (MB) nerve staining. - The RLN sheath was stained blue by MB in a concentration of 2:8 (MB: saline solution), which identify the RLN within the suspected structures. - The mean lobectomy duration, and the incidence of postoperative vocal cord palsy were sign... περισσότερα »
Tissue glue in wound healing of neck dissection
The impact of tissue glue in wound healing of head and neck patients undergoing neck dissection: AbstractWe investigated the impact of fibrin glue on postoperative drainage amount and duration in head and neck cancer patients who underwent neck dissection. This study was a prospective randomized controlled trial. Patients who were scheduled to undergo neck dissection due to head and neck cancer were eligible for this study. After receiving a detailed explanation, all patients signed an informed consent form before enrollment. Patients were then randomly assigned to the study group ...περισσότερα »
A minimally invasive laryngeal pacemaker system
Pre-clinical evaluation of a minimally invasive laryngeal pacemaker system in mini-pig: AbstractMicrolaryngoscopic enlargement techniques have been the standard treatment for bilateral vocal fold paralysis (BVFP) for decades. Laryngeal pacing is a promising alternative treatment based on the electrostimulation of the posterior cricoarytenoid (PCA) muscle. This paper reports on the results of a pre-clinical study aiming to evaluate this method. Eight Göttingen mini-pigs were implanted with a laryngeal pacemaker (LP) implant prototype and with two LP electrodes, one in each PCA muscl...περισσότερα »
4.5-mm-wide bone-anchored hearing implant
Stability, survival, and tolerability of a 4.5-mm-wide bone-anchored hearing implant: 6-month data from a randomized controlled clinical trial: AbstractThe objective of this study was to compare the stability, survival, and tolerability of 2 percutaneous osseointegrated titanium implants for bone conduction hearing: a 4.5-mm diameter implant (test) and a 3.75-mm diameter implant (control). Fifty-seven adult patients were included in this randomized controlled clinical trial. Sixty implants were allocated in a 2:1 (test–control) ratio. Follow-up visits were scheduled at 7, 14, 21, a... περισσότερα »
The effective stimulating pulse for restoration of blink function in unilateral facial nerve paralysis rabbits, verified by a simple FES system
The effective stimulating pulse for restoration of blink function in unilateral facial nerve paralysis rabbits, verified by a simple FES system: AbstractThe trains of 200 ms biphasic square pulses with the width of 9 ms delivered at 50 Hz were found to be the most suitable and effective mean as stimulation in FES system of restoring the blink function in unilateral facial nerve paralysis rabbit model. FES system is a reliable tool for these patients. Facial paralysis affects thousands of people every year. Many will have long term facial difficulties and the loss of the ability to ... περισσότερα »
Is endoscopic ear surgery an alternative to the modified Bondy technique for limited epitympanic cholesteatoma?
Is endoscopic ear surgery an alternative to the modified Bondy technique for limited epitympanic cholesteatoma?: AbstractThe objective of this study is to evaluate the outcomes of the modified Bondy’s technique performed at our center and for limited epitympanic cholesteatomas and to debate the purported benefits of endoscopic surgery for the same indication. This is a retrospective study. 269 ears of 258 patients with a minimum of 5-year follow-up that were operated for limited epitympanic cholesteatoma using the modified Bondy’s technique were included in the study. All patients ...περισσότερα »
Vestibular evoked myogenic potentials in patients with ankylosing spondylitis
Vestibular evoked myogenic potentials in patients with ankylosing spondylitis: AbstractAnkylosing spondylitis (AS) is a chronic systemic inflammatory disease with unknown etiology. Although sacroiliac joint involvement is the classic sign along with the formed immune mediators, it may result in immune-mediated inner ear disease and may cause damage to the audiovestibular system. Vestibular evoked myogenic potentials (VEMP) is a clinical reflex test used in the diagnosis of vestibular diseases and is performed by recording and evaluating the muscle potentials resulting from the sti... περισσότερα »
Caffeine on olfactory function
Short-term effect of caffeine on olfactory function in hyposmic patients: AbstractThe purpose of this study was to investigate the potential effects of caffeine in patients with olfactory loss. The suggested mechanisms of action consist in the non-selective blocking of adenosine receptors as well as inhibition of the phospodiesterase. Olfactory function was tested twice in 76 hyposmic patients either because of URTI or because of sinunasal causes. For definition of hyposmia and for later assessment of phenyl ethyl alcohol odor threshold, and odor discrimination the Sniffin Sticks da... περισσότερα »
Early Diagnosis and Surgery is Crucial to Survival Outcome in Rhinocerebral Mucormycosis
Early Diagnosis and Surgery is Crucial to Survival Outcome in Rhinocerebral Mucormycosis:
Mutational Analysis in Pediatric Thyroid Cancer and Correlations with Age, Ethnicity, and Clinical Presentation
Mutational Analysis in Pediatric Thyroid Cancer and Correlations with Age, Ethnicity, and Clinical Presentation: Thyroid , Vol. 0, No. 0. Author information Maria Eleni Nikita,1 Wen Jiang,2 Shih-Min Cheng,3 Feras M. Hantash,3 Michael J. McPhaul,3 Robert O. Newbury,4 Susan A. Phillips,1 Richard E. Reitz,3 Frederic M. Waldman,3 and Ron S. Newfield1 1Division of Pediatric Endocrinology, San Diego, and Rady Children's Hospital San Diego, California. 2Division of Pediatric Otolaryngology, San Diego, and Rady Children's Hospital San Diego, California. 3Hematology and Oncology, Quest Diag...περισσότερα »
Non-tuberculous mycobacterial head and neck infections in children
Non-tuberculous mycobacterial head and neck infections in children: Analysis of results and complications for various treatment modalities: Analyze the results and complications of various surgical interventions in a large cohort of children with Non-Tuberculous mycobacterial (NTM) head and neck infections and suggest a heuristic treatment protocol for managing this condition while aiming to maximize cure and minimize complications. AbstractObjective Analyze the results and complications of various surgical interventions in a large cohort of children with Non-Tuberculous mycobacte...περισσότερα »
Novel compound heterozygous mutations in gene associated with autosomal recessive sensorineural hearing loss in a Chinese family
Novel compound heterozygous mutations in gene associated with autosomal recessive sensorineural hearing loss in a Chinese family: Mutations in MYO7A gene have been reported to be associated with Usher Syndrome type 1B (USH1B) and nonsyndromic hearing loss (DFNB2, DFNA11). Most mutations in MYO7A gene caused USH1B, whereas only a few reported mutations led to DFNB2 and DFNA11. In this study, we present the clinical, genetic and molecular characteristics of a Chinese family with autosomal recessive hearing loss. Combining the targeted capture of 127 known deafness genes and next-gener... περισσότερα »
Effect of local anesthesia on facial nerve blood flow and muscle action potential
Effect of local anesthesia on facial nerve blood flow and muscle action potential: Background & Objective: The effect of direct application of local lidocaine with epinephrine on the facial nerve (FN) has not been reported. The aim of this study is to assess the effects of 2% lidocaine with 1:100,000 epinephrine at clinically relevant concentrations in a rat FN model with respect to facial nerve blood flow (FNBF) and subsequent electrophysiological changes. Abstract Background & Objective: The effect of direct application of local lidocaine with epinephrine on the facial nerve (F... περισσότερα »
Hereditary angioedema type 2 presented as an orbital complication of acute rhinosinusitis
Hereditary angioedema type 2 presented as an orbital complication of acute rhinosinusitis: Hereditary angioedema is an autosomal dominant and life-threatening disorder characterized by recurrent episodes of non-pitting edema affecting the skin, respiratory system and digestive tracts and caused by a congenital deficiency or function defect of the C1 esterase inhibitor. Preseptal cellulitis is defined as an infection of the tissues of the anterior orbital septum. It is generally caused by complications from an upper respiratory tract infection, dacryocystitis, dermal infection, and, ... περισσότερα »
Deeper insertion of electrode array result in better rehabilitation outcomes- do we have evidence?
Deeper insertion of electrode array result in better rehabilitation outcomes- do we have evidence?: To study the outcome analysis in cochlear implantees in relation to depth of insertion. AbstractObjective To study the outcome analysis in cochlear implantees in relation to depth of insertion. Methods 30 patients of non-syndromic congenital profound hearing loss in the age range of 2-12 years received cochlear implantation by a posterior tympanotomy round window approach. Depth of insertion was calculated using post-operative X-Rays (Modified Stenver's view) and categorized into fo... περισσότερα »
Charcoal Suspension Tattoo for Intraoperative Detection of Small Tumors of the Parotid Gland
Charcoal Suspension Tattoo: A New Technique for Intraoperative Detection of Small Tumors of the Parotid Gland: Objective: The current surgical trend in the treatment of pleomorphic adenomas of the parotid gland is to limit the extent of resection. This raises the need to correctly identify the mass within the normal parenchyma so as to avoid dissecting the entire superficial lobe of the gland. We describe ultrasound-guided tattooing as a technique to facilitate identification and excision of parotid pleomorphic adenomas. Methods: We reviewed 23 consecutive patients with pleomorphic... περισσότερα »
AKT Inhibition Promotes Cancer Cell Survival
Small molecule inhibitors of AKT (v-akt murine thymoma viral oncogene homolog) signaling are being evaluated in patients with various cancer types, but have so far proven therapeutically disappointing for reasons that remain unclear. Here, we treat cancer cells with subtherapeutic doses of Akti-1/2, an allosteric small molecule AKT inhibitor, in order to experimentally model pharmacologic… Continue reading AKT Inhibition Promotes Cancer Cell Survival
Selected Articles from This Issue
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ODR8ue via IFTTT
Fragment-Based Drug Design of HGF/SF-Met Antagonists
In many cancers, aberrant activation of the Met receptor tyrosine kinase leads to dissociation of cells from the primary tumor, causing metastasis. Accordingly, Met is a high-profile target for the development of cancer therapies, and progress has been made through development of small molecule kinase inhibitors and antibodies. However, both approaches pose significant challenges with… Continue reading Fragment-Based Drug Design of HGF/SF-Met Antagonists
Mutated Pathways in Breast Cancer Adjuvant Therapy Patients
Adjuvant therapy following breast cancer surgery generally consists of either a course of chemotherapy, if the cancer lacks hormone receptors, or a course of hormonal therapy, otherwise. Here, we report a correlation between adjuvant strategy and mutated pathway patterns. In particular, we find that for breast cancer patients, pathways enriched in nonsynonymous mutations in the… Continue reading Mutated Pathways in Breast Cancer Adjuvant Therapy Patients
DT01 in Preclinical Models of Colorectal Cancer Liver Metastasis
Metastatic liver disease from colorectal cancer is a significant clinical problem. This is mainly attributed to nonresectable metastases that frequently display low sensitivities to available chemotherapies and develop drug resistance partly via hyperactivation of some DNA repair functions. Combined therapies have shown some disease control; however, there is still a need for more efficient chemotherapies… Continue reading DT01 in Preclinical Models of Colorectal Cancer Liver Metastasis
Paclitaxel Tumor Distribution after Bevacizumab
The antitumor activity of angiogenesis inhibitors is reinforced in combination with chemotherapy. It is debated whether this potentiation is related to a better drug delivery to the tumor due to the antiangiogenic effects on tumor vessel phenotype and functionality. We addressed this question by combining bevacizumab with paclitaxel on A2780-1A9 ovarian carcinoma and HT-29 colon… Continue reading Paclitaxel Tumor Distribution after Bevacizumab
A Top1 Inhibitor Selectively Toxic for Certain NSCLC Cells
SW044248, identified through a screen for chemicals that are selectively toxic for non–small cell lung cancer (NSCLC) cell lines, was found to rapidly inhibit macromolecular synthesis in sensitive, but not in insensitive, cells. SW044248 killed approximately 15% of a panel of 74 NSCLC cell lines and was nontoxic to immortalized human bronchial cell lines. The… Continue reading A Top1 Inhibitor Selectively Toxic for Certain NSCLC Cells
TGF{alpha}-EGFR Signaling in Acquired Resistance to Alectinib
Alectinib is a highly selective ALK inhibitor and shows promising efficacy in non–small cell lung cancers (NSCLC) harboring the EML4-ALK gene rearrangement. The precise mechanism of acquired resistance to alectinib is not well defined. The purpose of this study was to clarify the mechanism of acquired resistance to alectinib in ALK-translocated lung cancer cells. We… Continue reading TGF{alpha}-EGFR Signaling in Acquired Resistance to Alectinib
Ang-(1-7) Inhibits Proliferation of NPC Cells
Angiotensin-(1-7) [Ang-(1-7)] is an endogenous, heptapeptide hormone acting through the Mas receptor (MasR), with antiproliferative and antiangiogenic properties. Recent studies have shown that Ang-(1-7) has an antiproliferative action on lung adenocarcinoma cells and prostate cancer cells. In this study, we report that MasR levels were significantly upregulated in nasopharyngeal carcinoma (NPC) specimens and NPC cell… Continue reading Ang-(1-7) Inhibits Proliferation of NPC Cells
KillerRed-Based Oncolytic Photodynamic Therapy
Photodynamic therapy (PDT) is a minimally invasive antitumor therapy that eradicates tumor cells through a photosensitizer-mediated cytotoxic effect upon light irradiation. However, systemic administration of photosensitizer often makes it difficult to avoid a photosensitive adverse effect. The red fluorescent protein KillerRed generates reactive oxygen species (ROS) upon green light irradiation. Here, we show the therapeutic… Continue reading KillerRed-Based Oncolytic Photodynamic Therapy
Addressing the Needs of Youth with HIV Infection in the Era of Combination Antiretroviral Therapy
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Reply to Dr Fierer
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HCV direct-acting antivirals in the "real world": Efficacy comparable to clinical trials
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Scale-up of routine viral load testing in resource-poor settings: current and future implementation challenges
Cost and complexity have hindered implementation to date of viral load testing in resource-limited settings. If rapid and timely scale-up is to become a reality, numerous factors will need to be addressed, including health and laboratory system strengthening, pricing, and multiple programmatic and funding challenges. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1S7tGrG via IFTTT
Vertebral osteomyelitis guidelines
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Progressive Multifocal Leukencephalopathy in Primary Immune Deficiencies: STAT1 Gain of Function and Review of the Literature
PML infrequently complicates primary immune deficiencies, especially those that have effects on both the lymphoid and myeloid systems from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1S7tGrw via IFTTT
Systematic review of the literature on viral persistence and sexual transmission from recovered Ebola survivors: evidence and recommendations
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective The main aim of this article is to present a comprehensive, systematic review on evidence of sexual transmission from Ebola survivors and persistence of Ebola virus in body fluids of relevance to sexual transmission, and additionally to review condom effectiveness against sexual transmission of Ebola. Design We performed a systematic review of viral persistence […]
A nationwide survey of public healthcare providers impressions of family medicine specialists in Malaysia: a qualitative analysis of written comments
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective To examine impressions of public healthcare providers/professionals (PHCPs) who are working closely with family medicine specialists (FMSs) at public health clinics. Design Cross-sectional study. Setting This study is part of a larger national study on the perception of Malaysian public healthcare professionals on FMSs (PERMFAMS). Participants PHCPs from three categories of health facility: hospitals, […]
Assessment of adult body composition using bioelectrical impedance: comparison of researcher calculated to machine outputted values
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives To explore the usefulness of Bioelectrical Impedance Analysis (BIA) for general use by identifying best-evidenced formulae to calculate lean and fat mass, comparing these to historical gold standard data and comparing these results with machine-generated output. In addition, we explored how to best to adjust lean and fat estimates for height and how these […]
A qualitative study exploring how Somali women exposed to female genital mutilation experience and perceive antenatal and intrapartum care in England
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives To explore how Somali women exposed to female genital mutilation experience and perceive antenatal and intrapartum care in England. We explored women’s perceptions of deinfibulation, caesarean section and vaginal delivery; their experiences of care during pregnancy and labour; and factors that affect ability to access these services, in order to make recommendations about future […]
What do pharmaceutical industry professionals in Europe believe about involving patients and the public in research and development of medicines? A qualitative interview study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives To explore European-based pharmaceutical industry professionals’ beliefs about patient and public involvement (PPI) in medicines research and development (R&D). Setting Pharmaceutical companies in the UK, Poland and Spain. Participants 21 pharmaceutical industry professionals, four based in the UK, five with pan-European roles, four based in Spain and eight based in Poland. Method Qualitative interview […]
‘Keeping your body and mind active: an ethnographic study of aspirations for healthy ageing
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective To describe and explore perceptions, practices and motivations for active living in later life. Design Qualitative study with semistructured interviews and ‘semistructured’ participant observations of participant-selected activities, such as exercise classes, private or organised walks, shopping and gardening. Participants 27 participants (65–80 years) from the European Prospective Investigation into Cancer Norfolk study, purposefully selected […]
A real-time spike classification method based on dynamic time warping for extracellular enteric neural recording with large waveform variability
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: 1 March 2016 Source:Journal of Neuroscience Methods, Volume 261 Author(s): Yingqiu Cao, Nikolai Rakhilin, Philip H. Gordon, Xiling Shen, Edwin C. Kan BackgroundComputationally efficient spike recognition methods are required for real-time analysis of extracellular neural recordings. The enteric nervous system (ENS) is important to human health but less well-understood with few appropriate spike […]
Corrigendum to ‘Meta-analysis of data from animal studies: A practical guide’
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: 1 February 2016 Source:Journal of Neuroscience Methods, Volume 259 Author(s): H.M. Vesterinen, E.S. Sena, K.J. Egan, T.C. Hirst, L. Churolov, G.L. Currie, A. Antonic, D.W. Howells, M.R. Macleod from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1O7WMDf via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by […]
Targeted Next-Generation Sequencing Analysis of a Pendred Syndrome-Associated Thyroid Carcinoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Pendred syndrome is an autosomal recessive disorder characterized by hearing loss and goiter and is caused by bi-allelic mutations (homozygous or compound heterozygous) of the PDS (SLC26A4) gene. The incidence of Pendred syndrome is 7.5–10/100,000 in the general population, and it carries a 1 % risk of developing thyroid carcinoma. Herein, we report a […]
PM&R Manuscript Reviewers
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
We extend our sincere gratitude to the following individuals who reviewed manuscripts for PM&R between November 2014 and October 2015. Peer-reviewers are the life-blood of scientific journals and their sacrifice of time and effort has greatly and specifically contributed to PM&R’s success. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1ZdXjMl via IFTTT Medicine by Alexandros […]
Selective Activator of the Glucocorticoid Receptor Compound A Dissociates Therapeutic and Atrophogenic Effects of Glucocorticoid Receptor Signaling in Skin.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Related Articles Selective Activator of the Glucocorticoid Receptor Compound A Dissociates Therapeutic and Atrophogenic Effects of Glucocorticoid Receptor Signaling in Skin. J Cancer Prev. 2015 Dec;20(4):250-9 Authors: Klopot A, Baida G, Bhalla P, Haegeman G, Budunova I Abstract BACKGROUND: Glucocorticoids are effective anti-inflammatory drugs widely used in dermatology and for the treatment of blood cancer […]
Targeted Next-Generation Sequencing Analysis of a Pendred Syndrome-Associated Thyroid Carcinoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Pendred syndrome is an autosomal recessive disorder characterized by hearing loss and goiter and is caused by bi-allelic mutations (homozygous or compound heterozygous) of the PDS (SLC26A4) gene. The incidence of Pendred syndrome is 7.5–10/100,000 in the general population, and it carries a 1 % risk of developing thyroid carcinoma. Herein, we report a […]
Calculating sample size. Alpha, Beta, Mu and Sigma – it’s all Greek
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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7-Rhamnosylated Flavonols Modulate Homeostasis of the Plant Hormone Auxin and Affect Plant Development Developmental Biology
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Flavonols are a group of secondary metabolites that affect diverse cellular processes. They are considered putative negative regulators of the transport of the phytohormone auxin, by which they influence auxin distribution and concomitantly take part in the control of plant organ development. Flavonols are accumulating in a large number of glycosidic forms. Whether these have […]
Filamin A Is Involved in HIV-1 Vpu Mediated Evasion of Host Restriction by Modulating Tetherin Expression Cell Biology
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Tetherin, also known as bone marrow stromal antigen 2 (BST-2), inhibits the release of a wide range of enveloped viruses including HIV-1 by directly tethering nascent virions to the surface of infected cells. HIV-1 accessary protein Vpu counteracts tetherin restriction via sequestration, downregulation, and/or displacement mechanisms to remove tetherin from the sites of virus budding. […]
Evolutionary Ancestry of Eukaryotic Protein Kinases and Choline Kinases Computational Biology
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The reversible phosphorylation of proteins catalyzed by protein kinases in eukaryotes supports an important role for eukaryotic protein kinases (ePKs) in the emergence of nucleated cells in the third superkingdom of life. Choline kinases (ChKs) could also be critical in the early evolution of eukaryotes, because of their function in the biosynthesis of phosphatidylcholine, which […]
Targeted Next-Generation Sequencing Analysis of a Pendred Syndrome-Associated Thyroid Carcinoma
Abstract Pendred syndrome is an autosomal recessive disorder characterized by hearing loss and goiter and is caused by bi-allelic mutations (homozygous or compound heterozygous) of the PDS (SLC26A4) gene. The incidence of Pendred syndrome is 7.5–10/100,000 in the general population, and it carries a 1 % risk of developing thyroid carcinoma. Herein, we report a… Continue reading Targeted Next-Generation Sequencing Analysis of a Pendred Syndrome-Associated Thyroid Carcinoma
Calculating sample size. Alpha, Beta, Mu and Sigma – it’s all Greek
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Jy1ueI via IFTTT
7-Rhamnosylated Flavonols Modulate Homeostasis of the Plant Hormone Auxin and Affect Plant Development Developmental Biology
Flavonols are a group of secondary metabolites that affect diverse cellular processes. They are considered putative negative regulators of the transport of the phytohormone auxin, by which they influence auxin distribution and concomitantly take part in the control of plant organ development. Flavonols are accumulating in a large number of glycosidic forms. Whether these have… Continue reading 7-Rhamnosylated Flavonols Modulate Homeostasis of the Plant Hormone Auxin and Affect Plant Development Developmental Biology
Filamin A Is Involved in HIV-1 Vpu Mediated Evasion of Host Restriction by Modulating Tetherin Expression Cell Biology
Tetherin, also known as bone marrow stromal antigen 2 (BST-2), inhibits the release of a wide range of enveloped viruses including HIV-1 by directly tethering nascent virions to the surface of infected cells. HIV-1 accessary protein Vpu counteracts tetherin restriction via sequestration, downregulation, and/or displacement mechanisms to remove tetherin from the sites of virus budding.… Continue reading Filamin A Is Involved in HIV-1 Vpu Mediated Evasion of Host Restriction by Modulating Tetherin Expression Cell Biology
Rhizobiale-like phosphatase 2 from Arabidopsis thaliana is a novel phospho-tyrosine specific PPP-family protein phosphatase Signal Transduction
Cellular signaling through protein tyrosine phosphorylation is well established in mammalian cells. Although lacking the classic tyrosine kinases present in humans, plants have a tyrosine phosphoproteome that rivals human cells. Here we report a novel plant tyrosine phosphatase from Arabidopsis thaliana (AtRLPH2) that surprisingly, has the sequence hallmarks of a phospho-serine/threonine phosphatase belonging to the… Continue reading Rhizobiale-like phosphatase 2 from Arabidopsis thaliana is a novel phospho-tyrosine specific PPP-family protein phosphatase Signal Transduction
Evolutionary Ancestry of Eukaryotic Protein Kinases and Choline Kinases Computational Biology
The reversible phosphorylation of proteins catalyzed by protein kinases in eukaryotes supports an important role for eukaryotic protein kinases (ePKs) in the emergence of nucleated cells in the third superkingdom of life. Choline kinases (ChKs) could also be critical in the early evolution of eukaryotes, because of their function in the biosynthesis of phosphatidylcholine, which… Continue reading Evolutionary Ancestry of Eukaryotic Protein Kinases and Choline Kinases Computational Biology
Conserved amphipathic helices mediate lipid droplet targeting of perilipins 1-3. Cell Biology
Perilipins (PLINs) play a key role in energy storage by orchestrating the activity of lipases on the surface of lipid droplets (LDs). Failure of this activity results in severe metabolic disease in humans. Unlike all other lipid droplet associated proteins, PLINs localise almost exclusively to the phospholipid monolayer surrounding the droplet. To understand how they… Continue reading Conserved amphipathic helices mediate lipid droplet targeting of perilipins 1-3. Cell Biology
Identification of glycosylation sites essential for surface expression of the CaV{alpha}2{delta} 1 subunit and modulation of the cardiac CaV1.2 channel activity Protein Structure and Folding
Alterations in the L-type current density is one aspect of the electrical remodeling observed in patients suffering from cardiac arrhythmias. Changes in channel function could result from variations in the protein biogenesis, stability, post-translational modification, and/or trafficking in any of the regulatory subunits forming cardiac L-type Ca2+ channel complexes. CaVα2δ1 is potentially the most heavily… Continue reading Identification of glycosylation sites essential for surface expression of the CaV{alpha}2{delta} 1 subunit and modulation of the cardiac CaV1.2 channel activity ... περισσότερα »
NusG is a Sequence-specific RNA Polymerase Pause Factor that Binds to the Non-template DNA Within the Paused Transcription Bubble Microbiology
NusG, referred to as Spt5 in archaeal and eukaryotic organisms, is the only transcription factor conserved in all three domains of life. This general transcription elongation factor binds to RNA polymerase (RNAP) soon after transcription initiation and dissociation of the RNA polymerase σ factor. Escherichia coli NusG increases transcription processivity by suppressing RNAP pausing, whereas… Continue reading NusG is a Sequence-specific RNA Polymerase Pause Factor that Binds to the Non-template DNA Within the Paused Transcription Bubble Microbiology
Heterogeneity of Collagen VI Microfibrils: Structural Analysis of Non-collagenous Regions Glycobiology and Extracellular Matrices
Collagen VI, a collagen with uncharacteristically large N- and C-terminal non-collagenous regions, forms a distinct microfibrillar network in most connective tissues. It was long considered to consist of three genetically distinct α chains (α1, α2 and α3). Intracellularly heterotrimeric molecules associate to form dimers and tetramers, which are then secreted and assembled to microfibrils. The… Continue reading Heterogeneity of Collagen VI Microfibrils: Structural Analysis of Non-collagenous Regions Glycobiology and Extracellular Matrices
EDITORIAL
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Issue Information – Table of Contents
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Reply to Bruun et al.
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How generalizable are the results from trials of Direct Antiviral Agents to people coinfected with HIV/Hepatitis C virus in the real world?
Trial results are used to support licensure, inform cost-effectiveness analyses and guide clinical decision-making. We found the majority of co-infected patients were not included in clinical trials of DAAs, raising concerns about the generalizability of these trial results. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1S7tHMe via IFTTT
Etiology of Cellulitis and the Validity of New and Old Methods
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Complex mode of inheritance in holoprosencephaly revealed by whole exome sequencing
Abstract Holoprosencephaly (HPE) is the most common congenital cerebral malformation, characterized by impaired forebrain cleavage and midline facial anomalies. Heterozygous mutations in 14 genes have been associated with HPE, and are often inherited from an unaffected parent underlying complex genetic bases. It is now emerging that HPE may result from a combination of multiple genetic events, rather than from a single heterozygous mutation. To explore this hypothesis, we undertook whole exome sequencing (WES) and targeted high-throughput sequencing approaches to identify mutation...περισσότερα »
The c.65-2A>G splice site mutation is associated with a mild phenotype in Danon disease due to the transcription of normal LAMP2 mRNA
Abstract Danon disease (DD) is a rare X-linked multisystem disorder caused by mutations of the LAMP2 gene and characterized by intellectual disability, skeletal myopathy and cardiomyopathy. The survival time is severely reduced. Contrasting with the usual disease course we report on a family with an exceptionally mild phenotype of DD despite having two potentially damaging LAMP2 mutations. Using RNA-Seq analysis we showed that a c.65-2A>G splice site mutation results in the tissue-specific production of four different transcripts including the full-length mRNA in muscle tissue but ...περισσότερα »
Physical exercise modulates the homeostasis of human regulatory T cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: Available online 7 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Max Weinhold, Alexander Shimabukuro-Vornhagen, Axel Franke, Sebastian Theurich, Patrick Wahl, Michael Hallek, Annette Schmidt, Timo Schinköthe, Joachim Mester, Michael von Bergwelt-Baildon, Wilhelm Bloch from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Pig8U8 via IFTTT
Childhood asthma exacerbations and the Arg16 β2-receptor polymorphism: A meta-analysis stratified by treatment
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: Available online 7 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Steve Turner, Ben Francis, Susanne Vijverberg, Maria Pino-Yanes, Anke H. Maitland-van der Zee, Kaninika Basu, Lauren Bignell, Somnath Mukhopadhyay, Roger Tavendale, Colin Palmer, Daniel Hawcutt, Munir Pirmohamed, Esteban G. Burchard, Brian Lipworth BackgroundThe Gly-to-Arg substitution at the 16 position (rs1042713) in […]
Parameters determining the efficacy of CD32 to inhibit activation of FcεRI in human basophils
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: Available online 7 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Donald MacGlashan, Robert G. Hamilton from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Pig7zu via IFTTT
IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: Available online 7 January 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Avanti Desai, Mi-Yeon Jung, Ana Olivera, Alasdair M. Gilfillan, Calman Prussin, Arnold S. Kirshenbaum, Michael A. Beaven, Dean D. Metcalfe BackgroundIL-6, levels of which are reported to be increased in association with mastocytosis, asthma, and urticaria, is used in conjunction with […]
Colistin resistance gene mcr-1 in extended-spectrum β-lactamase-producing and carbapenemase-producing Gram-n egative bacteria in Germany
Publication date: Available online 8 January 2016 Source:The Lancet Infectious Diseases Author(s): Linda Falgenhauer, Said-Elias Waezsada, Yancheng Yao, Can Imirzalioglu, Annemarie Käsbohrer, Uwe Roesler, Geovana Brenner Michael, Stefan Schwarz, Guido Werner, Lothar Kreienbrock, Trinad Chakraborty from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RnjsDD via IFTTT
Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli
Publication date: Available online 8 January 2016 Source:The Lancet Infectious Diseases Author(s): Laurent Poirel, Nicolas Kieffer, Nadia Liassine, Dang Thanh, Patrice Nordmann from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RnjsDz via IFTTT
Investigation of a plasmid genome database for colistin-resistance gene mcr-1
Publication date: Available online 8 January 2016 Source:The Lancet Infectious Diseases Author(s): Satowa Suzuki, Mamoru Ohnishi, Michiko Kawanishi, Masato Akiba, Makoto Kuroda from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OT4oH6 via IFTTT
Colistin resistance gene mcr-1 harboured on a multidrug resistant plasmid
Publication date: Available online 8 January 2016 Source:The Lancet Infectious Diseases Author(s): Surbi Malhotra-Kumar, Basil Britto Xavier, Anupam J Das, Christine Lammens, Patrick Butaye, Herman Goossens from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Rnjsn7 via IFTTT
Colistin-resistant Escherichia coli harbouring mcr-1 isolated from food animals in Hanoi, Vietnam
Publication date: Available online 8 January 2016 Source:The Lancet Infectious Diseases Author(s): Surbhi Malhotra-Kumar, Basil Britto Xavier, Anupam J Das, Christine Lammens, Ha Thi Thu Hoang, Ngoc Thi Pham, Herman Goossens from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OT4qi2 via IFTTT
Colistin resistance gene mcr-1 and pHNSHP45 plasmid in human isolates of Escherichia coli and Klebsiella pneumoniae
Publication date: Available online 8 January 2016 Source:The Lancet Infectious Diseases Author(s): Nicole Stoesser, Amy J Mathers, Catrin E Moore, Nicholas PJ Day, Derrick W Crook from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OT4oa6 via IFTTT
