Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Πέμπτη 4 Αυγούστου 2016

OtoRhinoLaryngology & Medicine,New Articles,August 5th,2016


OtoRhinoLaryngology - Alexandros G. Sfakianakis
Photodynamic therapy (PDT) has been developed as a promising treatment modality for laryngeal cancer.
A combined modality of carboplatin and photodynamic therapy suppresses epithelial-mesenchymal transition and matrix metalloproteinase-2 (MMP-2)/MMP-9 expression in HEp-2 human laryngeal cancer cells via ROS-mediated inhibition of MEK/ERK signalling pathway: AbstractPhotodynamic therapy (PDT) has been...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
ALT-803, a novel IL-15/IL-15 receptor alpha complex, and the tyrosine kinase inhibitor, sunitinib
The immunomodulatory, antitumor and antimetastatic responses of melanoma-bearing normal and alcoholic mice to sunitinib and ALT-803: a combinatorial treatment approach: AbstractALT-803, a novel IL-15/IL-15 receptor alpha complex, and the tyrosine kinase inhibitor, sunitinib, were examined for their single...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Reference dosimetry in magnetic fields: formalism and ionization chamber correction factors
Reference dosimetry in magnetic fields: formalism and ionization chamber correction factors: Purpose: Magnetic resonance imaging–guided radiotherapy (MRIgRT) provides superior soft-tissue contrast and real-time imaging compared with standard image-guided RT, which uses x-ray based imaging. Several groups...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
CNR considerations for rapid real-time MRI tumor tracking in radiotherapy hybrid devices
Effects of B0 field strength: Purpose: This work examines the subject of contrast-to-noise ratio (CNR), specifically between tumor and tissue background, and its dependence on the MRI field strength, B 0. This examination is motivated by the recent interest and developments...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
BASCULE syndrome (Bier's Anemic Spots associated with Cyanosis and Urticaria-Like Eruption), orthostatic cyanosis and postural orthostatic tachycardia syndrome (POTS)
 time for decanting old wine?: AbstractWe thank Dr McGibbon for his comments on the BASCULE syndrome (Bier's Anemic Spots associated with Cyanosis and Urticaria-Like Eruption).The author suggests that this syndrome is essentially a redescription of “orthostatic acrocyanosis (OA)” associated with chronic...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Gender effects on naevi body distribution and melanoma risk in two melanoma case control studies at different latitudes
Gender effects on naevi body distribution and melanoma risk in two melanoma case control studies at different latitudes: AbstractNaevus count is the most predictable phenotypic risk factor for melanoma and is mainly influenced by genetic factors1,2,3. Melanoma disparities according to gender have been...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Cytoskeletal defects.Skin lesions that are 1- to 2-mm slightly keratotic red to dark brown papules.
Mutations in POGLUT1 in Galli–Galli /Dowling Degos-Diseaseby N.J. Wilson, C. Cole, K. Kroboth, W.N. Hunter, J.A. Mann, W.H. Irwin McLean, K. Kernland Lang, H. Beltraminelli, R.A. Sabroe, N. Tiffin, G.J. Sobey, L. Borradori, E. Simpson, F.J.D. Smith via British Journal of DermatologyAbstractThe group...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The crosstalk between renal function, inflammation and psoriasis vulgaris
The crosstalk between renal function, inflammation and psoriasis vulgaris: AbstractIt has been reported that moderate-to-severe psoriasis present an increased risk for CKD, that is independent of traditional risk factors 2,3; and severe psoriasis was proposed as a risk factor for CKD and end-stage CKD...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Chronic Pruritus: Evaluation of Patient Needs and Treatment Goals with a Special Regard to Differences According to Pruritus Classification and Gender Aspects
Chronic Pruritus: Evaluation of Patient Needs and Treatment Goals with a Special Regard to Differences According to Pruritus Classification and Gender Aspects: AbstractBackground and ObjectiveChronic pruritus (CP) is present in approximately one third of all dermatological patients. Diagnostics and treatment...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Febrile Neutropenia
Comparing the Incidence Of Febrile Neutropenia Resulting in Hospital Admission Between the Branded Docetaxel And the Generic Formulations: AbstractStudies have raised concern about the safety of generic compared with branded drugs. Febrile neutropenia (FN) resulting in hospital admission was compared...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The importance of serine metabolism in cancer
The importance of serine metabolism in cancer: Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversial. In many cases, extracellular serine alone is sufficient to support cancer cell proliferation, whereas some cancer cells increase...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Primary ciliogenesis
Novel role for the midbody in primary ciliogenesis by polarized epithelial cells: The primary cilium is a membrane protrusion that is crucial for vertebrate tissue homeostasis and development. Here, we investigated the uncharacterized process of primary ciliogenesis in polarized epithelial cells. We...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Pierre-Robin Sequence
Sleep architecture in Pierre-Robin sequence: The effect of mandibular distraction osteogenesisvia International Journal of Pediatric OtorhinolaryngologyPublication date: October 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 89Author(s): J.N. Bangiyev, H. Traboulsi, I. Abdulhamid,...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Cranial dural permeability of inflammatory nociceptive mediators: Potential implications for animal models of migraine
Cranial dural permeability of inflammatory nociceptive mediators: Potential implications for animal models of migraine: BackgroundApplication of inflammatory mediators to the cranial dura has been used as a method to activate and sensitize neurons in the meningeal sensory pathway in preclinical behavioral...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The stapedius (acoustic) reflex (SR) test is useful in identifying the site of facial nerve injury. The return of the SR (acoustic) to normal after an injury is a good prognostic factor in the treatment of facial nerve palsy.
Article in PressEvaluation of the acoustic (stapedius) reflex test in children and adolescents with peripheral facial nerve palsyWacław KopalaPress enter key for correspondence informationPress enter key to Email the author, Andrzej KukwaDOI: http://dx.doi.org/10.1016/j.ijporl.2016.08.001Article InfoAbstractFull...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Epilaryngeal constrictions
Article in PressOscillatory Characteristics of the Vocal Folds Across the Tenor PassaggioMatthias EchternachPress enter key for correspondence informationPress enter key to Email the author, Fabian Burk, Marie Köberlein, Christian T. Herbst, Michael Döllinger, Michael Burdumy, Bernhard RichterDOI: http://dx.doi.org/10.1016/j.jvoice.2016.06.015Article...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Combined Rhinoplasty and Septal Perforation Repair
Combined Rhinoplasty and Septal Perforation Repair: Importance  Combined rhinoplasty and septal perforation repair is a technically challenging procedure, and few studies have reported the outcomes.Objective  To present the long-term surgical results of rhinoplasty with concurrent septal perforation...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Clinical features of delayed endolymphatic hydrops and intralabyrinthine schwannoma
Clinical features of delayed endolymphatic hydrops and intralabyrinthine schwannoma: AbstractBackgroundThe aim of this study was to compare the clinical history and audiovestibular function test results of patients suffering from intralabyrinthine schwannoma or delayed endolymphatic hydrops (DEH).Patients...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Klinische Eigenschaften von „delayed endolymphatic hydrops“ und intralabyrinthärem Schwannom
Klinische Eigenschaften von „delayed endolymphatic hydrops“ und intralabyrinthärem Schwannom: ZusammenfassungHintergrundZiel der Studie war es, die Krankengeschichte und die Befunde in audiovestibulären Funktionsuntersuchungen bei Patienten mit intralabyrinthärem Schwannom oder „delayed endolymphatic...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Hearing Evaluations in Patients Undergoing Tympanostomy Tube Placement
Hearing Evaluations in Patients Undergoing Tympanostomy Tube Placement: This case series reviews appropriate use of perioperative hearing evaluations in conjunction with tympanostomy tube placement.Importance  Obtaining hearing thresholds is an important step in the evaluation of a child with otitis...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Intraoperative Neuromonitoring and Reduced RLN Injury in Total Thyroidectomy
Intraoperative Neuromonitoring and Reduced RLN Injury in Total Thyroidectomy: This cohort study compares the incidence of recurrent laryngeal nerve injury in total thyroidectomy patients who had intraoperative neuromonitoring vs those who had nerve visualization alone.Importance  Injury of the recurrent...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Effects of Extracorporeal Septoplasty on Nasal Tip
Effects of Extracorporeal Septoplasty on Nasal Tip: This study evaluates the outcomes of open-approach extracorporeal septoplasty without simultaneous rhinoplasty in terms of nasal tip projection and rotation using objective measurements.Importance  Performing an open-approach extracorporeal septoplasty...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Destructive Otologic Foreign Body—Dangers of the Expanding Bead
Destructive Otologic Foreign Body—Dangers of the Expanding Bead: This case series examines the dangers of superabsorbent polymer beads to otologic structures in the external auditory canal.Foreign bodies of the external auditory canal (EAC-FB) are a common presentation to the emergency department (ED),...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Endoscopy Dyspnea and Ulcerative Colitis
Endoscopy Dyspnea and Ulcerative Colitis: A woman had progressive sore throat, dysphagia, and fever that developed into dyspnea, dysphonia, and neck pain; laryngoscopy showed erythema and edema of the epiglottitis with patchy necrosis partially obstructing the glottis and saliva pooling in the supraglottis....
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Oral cancer: Biomarker targets predominately involve deregulated molecular events that participate in cell signalling, growth, survival, motility, angiogenesis and cell cycle control but can also use changes in metabolic genes to discriminate healthy form disease state. Promising potential biomarkers include the growth signalling oncogenes, Epidermal Growth Factor Receptor and Cyclin D1, the anti-growth signalling components p53 and p21, apoptotic effectors such as Bcl-2 and also components involved in immortalisation, angiogenesis, invasion and metastasis processes.
 Deregulated molecular events and their use as biomarkersvia ScienceDirect Publication: Oral OncologyPublication date: October 2016Source:Oral Oncology, Volume 61Author(s): Nicoleta Sinevici, Jeff O’sullivanOral Cancer (OC) is a subset of head and neck cancer (HNC) with an annual worldwide incidence...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Head and neck lymphatic malformation and treatment
: Clinical study of 23 casesvia European Annals of Otorhinolaryngology, Head and Neck DiseasesSource:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): J. Lerat, C. Mounayer, A. Scomparin, S. Orsel, J.-P. Bessede, K. AubryObjectivesHead and neck lymphatic malformation is a rare...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Using peak direct subglottic pressure level as an objective measure during medialization thyroplasty
a prospective study: AbstractType I medialization thyroplasty (MT) was introduced by Isshiki more than 40 years ago. It is one of the most widely used surgical options to correct glottic insufficiency. Intraoperatively, the surgeon relies solely on perceptual subjective measures to help to achieve an...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Cardiac comorbidity in head and neck cancer patients
 and its influence on cancer treatment selection and mortality: a prospective cohort study: AbstractComorbidity assessment and a profound cardiac examination were implemented into pre-treatment diagnostics to analyze their influence on head and neck squamous cell carcinoma (HNSCC) therapy selection and...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Quantification of lymph nodes in the central compartment of the neck
a cadaveric study: AbstractDifferentiated thyroid cancer (DTC) accounts for over 90 % of thyroid malignancies, and is frequently associated with central neck compartment nodal metastasis that requires a therapeutic central compartment neck dissection (CCND) for clinically evident nodes. Current knowledge...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Is it safe to perform adenotonsillectomy in children with Down syndrome?
Is it safe to perform adenotonsillectomy in children with Down syndrome?: AbstractThis retrospective review aims to evaluate the postoperative morbidity and mortality of 30 patients with Down syndrome who underwent adenotonsillectomy between June 2012 and December 2015 in a tertiary referral center....
OtoRhinoLaryngology - Alexandros G. Sfakianakis
The importance of early diagnosis in patients with maxillary sinus carcinoma
The importance of early diagnosis in patients with maxillary sinus carcinoma: AbstractThere are two major challenges in the early diagnosis of maxillary sinus carcinoma: the maxillary sinus is not susceptible to direct inspection and palpation, and symptoms are uncharacteristic. The aim of this study...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Expansion sphincter pharyngoplasty for the treatment of OSA
 a systemic review and meta-analysis: AbstractThis study seeks to determine the success rates of the expansion sphincter pharyngoplasty and its variants on the treatment of obstructive sleep apnea (OSA). Systematic review and meta-analysis. Two independent searches of MEDLINE, Google Scholar, Cochrane...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Monitoring of microvascular free flaps following oropharyngeal reconstruction using infrared thermography: first clinical experiences
Monitoring of microvascular free flaps following oropharyngeal reconstruction using infrared thermography: first clinical experiences: AbstractThe aim of this study is to investigate static and dynamic infrared (IR) thermography for intra- and postoperative free-flap monitoring following oropharyngeal...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Protective Effect of Korean Red Ginseng On Cisplatin Ototoxicity:
Is It Effective Enough?:J Int Adv Otol. 2016 Aug 3;Authors: Olgun Y, Kırkım G, Altun Z, Aktaş S, Kolatan E, Kiray M, Bağrıyanık A, Olgun A, Kızmazoğlu DÇ, Özoğul C, Ellidokuz H, Erçetin P, Şerbetçioğlu B, Yılmaz O, Güneri EAAbstract OBJECTIVE: The aim of our study was to investigate the effects...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Gout: Tophi in the Middle Ear
An Unusual Presentation of J Int Adv Otol. 2016 Aug 3;Authors: Mutlu A, Dündar E, İşeri M, Erçin C, Cefle AAbstract Gout is a common metabolic disease and is characterized by episodic acute and chronic arthritis caused by the deposition of monosodium urate (MSU) crystals in joints and connective...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Clinical features of delayed endolymphatic hydrops and intralabyrinthine schwannoma
Clinical features of delayed endolymphatic hydrops and intralabyrinthine schwannoma: AbstractBackgroundThe aim of this study was to compare the clinical history and audiovestibular function test results of patients suffering from intralabyrinthine schwannoma or delayed endolymphatic hydrops (DEH).Patients...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Intratympanic corticosteroids injections: a systematic review of literature
Intratympanic corticosteroids injections: a systematic review of literature: AbstractThe objective of the study was to determine the evidence of intratympanic steroids injections (ITSI) for efficacy in the management of the following inner ear diseases: Ménière’s disease, tinnitus, noise-induced hearing...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Neurofibroma around the Ear Canal: Report of Three Cases.
Neurofibroma around the Ear Canal: Report of Three Cases.: Neurofibroma around the Ear Canal: Report of Three Cases.J Int Adv Otol. 2016 Aug 3;Authors: Satar B, Hıdır Y, Aşık MB, Aydın Ü, Gerek M, Yavan İAbstract Facial nerve neurofibromas are an uncommon entity, particularly in the intraparotid...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Focal Endolymphatic Hydrops as Seen in the Pars Inferior of the Human Inner Ear
Focal Endolymphatic Hydrops as Seen in the Pars Inferior of the Human Inner Ear: Hypothesis: Endolymphatic hydrops of the human inner ear may be localized focally in the pars inferior of the human inner ear. Background: Endolymphatic hydrops may be found in the human inner ear in patients who in life...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Croton oil-induced ear edema in mice, acetic acid-induced vascular permeability in mice and carrageenan induced-pleurisy in rats were conducted as acute inflammation models.
Anti-inflammatory and immunomodulatory properties of Pistacia lentiscus extracts: 2016-08-03T17-57-37ZSource: Journal of Applied Pharmaceutical ScienceHamama Bouriche, Asma Saidi, Ayoub Ferradji, Sahra Amel Belambri, Abderrahmane Senator. This study aimed to evaluate the anti-inflammatory activity of...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy in Survivors of Adult-Onset Cancer [Treatment-Related Complications]
Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy in Survivors of Adult-Onset Cancer [Treatment-Related Complications]: PurposeCisplatin is widely used but highly ototoxic. Effects of cumulative cisplatin dose on hearing loss have not been comprehensively...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Immunohistochemical techniques for the human inner ear.
Immunohistochemical techniques for the human inner ear.Histochem Cell Biol. 2016 Aug ;Authors: Lopez IA, Ishiyama G, Hosokawa S, Hosokawa K, Acuna D, Linthicum FH, Ishiyama AAbstract In this review, we provide a description of the recent methods used for immunohistochemical staining of the human...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Acoustic effects of the reconstructed lateral epitympanic wall in a temporal bone
 and clinical study.Laryngoscope. 2016 Aug ;Authors: Gostian AO, Schwarz D, Pazen D, Anagiotos A, Ortmann M, Hüttenbrink KB, Beutner DAbstract OBJECTIVE: Acoustic evaluation of reconstruction of the lateral epitympanic wall with bone or cartilage in a temporal bone study, and evaluation of audiometric...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing
Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing: The stria vascularis is a nonsensory structure that is essential for auditory hair cell function by maintaining potassium concentration of the scala media. During mouse embryonic...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Outer Hair Cell Molecular Protein, Prestin, as a Serum Biomarker for Hearing Loss: Proof of Concept.
Outer Hair Cell Molecular Protein, Prestin, as a Serum Biomarker for Hearing Loss: Proof of Concept.: Hypothesis: At present there are no serum biomarkers available to monitor cochlear health in those at risk of hearing loss. Outer hair cells (OHCs) play an important role in cochlear function and are...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Transcanal Endoscopic Ear Surgery for the Management of Congenital Ossicular Fixation.
Transcanal Endoscopic Ear Surgery for the Management of Congenital Ossicular Fixation.: Objectives: 1) To describe the technique for transcanal endoscopic management of congenital ossicular chain fixation. 2) To highlight the utility and outcomes of the endoscopic approach for management of congenital...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
High Resolution MRI Shows Presence of Endolymphatic Hydrops in Patients Still Symptomatic After Endolymphatic Shunt Surgery.
High Resolution MRI Shows Presence of Endolymphatic Hydrops in Patients Still Symptomatic After Endolymphatic Shunt Surgery.: Objective: Endolymphatic hydrops has been well described in patients with Meniere's syndrome; however, causation has not been established. Decompression of the endolymphatic sac...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Genetic and Environmental Determinants of Otitis Media in an Indigenous Filipino Population
Genetic and Environmental Determinants of Otitis Media in an Indigenous Filipino Population: ObjectiveTo identify genetic and environmental risk factors for otitis media in an indigenous Filipino population.Study DesignCross-sectional study.SettingIndigenous Filipino community.Subjects and MethodsClinical...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Bimodal Stimulation in Prelingually Deaf Children: Lessons from a Cross-sectional Survey
Bimodal Stimulation in Prelingually Deaf Children: Lessons from a Cross-sectional Survey: Objective(1) To survey the use of bimodal stimulation by prelingually deaf children receiving unilateral cochlear implantation and (2) to investigate demographic and audiologic factors explaining the use of bimodal...


OtoRhinoLaryngology - Alexandros G. Sfakianakis
Diminishing return for mechanistic therapeutics with neurodegenerative disease duration?
Diminishing return for mechanistic therapeutics with neurodegenerative disease duration?: The conventional approach to developing disease-modifying treatments for neurodegenerative conditions has been to identify drivers of pathology and inhibit such pathways. Here we discuss the possibility that the...
OtoRhinoLaryngology - Alexandros G. Sfakianakis
Optimal cue combination and landmark-stability learning in the head direction system
Optimal cue combination and landmark-stability learning in the head direction system: Maintaining a sense of direction requires combining information from static environmental landmarks together with dynamic information about self-motion. This is accomplished by the head direction system, whose neurons...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
ASBA Huffington Post Blog-Untreated Sleep Apnea in Children Could Contribute to ADHD and Behavioral Problems Part 2
This is part two in a three-part series on how sleep apnea affects behavior and learning in children. First, the signs and symptoms of sleep apnea in children. Second, the origin and factors that can lead to sleep disorders and third, are possible treatment plans to consider…. To read more of this week's...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
“An assessment of the compliance of systematic review articles published in craniofacial surgery with the PRISMA statement guidelines: A systematic review”
Publication date: Available online 3 August 2016Source:Journal of Cranio-Maxillofacial Surgery Author(s): Thomas Edward Pidgeon, Georgina Wellstead, Harkiran Sagoo, Daniyal Jalil Jafree, Alexander J. Fowler, Riaz A. Agha ContextSystematic review evidence is increasing within craniofacial surgery. Compliance...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Does CBCT scans alter surgical treatment plans? Comparison of preoperative surgical diagnosis using panoramic versus cone-beam CT images
Publication date: Available online 3 August 2016Source:Journal of Cranio-Maxillofacial Surgery Author(s): Carolina Wolff, Thomas Mücke, Stefan Wagenpfeil, Anastasios Kanatas, Oliver Bissinger, Herbert Deppe Cone beam CT and/or panoramic images are often required for a successful diagnosis in oral and...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Combined Rhinoplasty and Septal Perforation Repair
This case series study examines surgical techniques and long-term outcomes in rhinoplasty combined with septal perforation repair among patients with nasal deformity and septal perforation. http://ift.tt/2alnc9X
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Clinical features of delayed endolymphatic hydrops and intralabyrinthine schwannoma
Abstract Background The aim of this study was to compare the clinical history and audiovestibular function test results of patients suffering from intralabyrinthine schwannoma or delayed endolymphatic hydrops (DEH). Patients and methods Five patients diagnosed with intralabyrinthine schwannoma by...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Onkologie II
http://ift.tt/2aTpYDb
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Klinische Eigenschaften von „delayed endolymphatic hydrops“ und intralabyrinthärem Schwannom
Zusammenfassung Hintergrund Ziel der Studie war es, die Krankengeschichte und die Befunde in audiovestibulären Funktionsuntersuchungen bei Patienten mit intralabyrinthärem Schwannom oder „delayed endolymphatic hydrops" (DEH) zu vergleichen. Patienten und Methoden Retrospektiv wurden die Daten von...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Hearing Evaluations in Patients Undergoing Tympanostomy Tube Placement
This case series reviews appropriate use of perioperative hearing evaluations in conjunction with tympanostomy tube placement. http://ift.tt/2aDjSTC
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Intraoperative Neuromonitoring and Reduced RLN Injury in Total Thyroidectomy
This cohort study compares the incidence of recurrent laryngeal nerve injury in total thyroidectomy patients who had intraoperative neuromonitoring vs those who had nerve visualization alone. http://ift.tt/2aAIAqw
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Effects of Extracorporeal Septoplasty on Nasal Tip
This study evaluates the outcomes of open-approach extracorporeal septoplasty without simultaneous rhinoplasty in terms of nasal tip projection and rotation using objective measurements. http://ift.tt/2aosWeA
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Destructive Otologic Foreign Body—Dangers of the Expanding Bead
This case series examines the dangers of superabsorbent polymer beads to otologic structures in the external auditory canal. http://ift.tt/2aAIEql
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Endoscopy Dyspnea and Ulcerative Colitis
A woman had progressive sore throat, dysphagia, and fever that developed into dyspnea, dysphonia, and neck pain; laryngoscopy showed erythema and edema of the epiglottitis with patchy necrosis partially obstructing the glottis and saliva pooling in the supraglottis. What is your diagnosis? http://ift.tt/2aAIWgY
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Oral cancer: Deregulated molecular events and their use as biomarkers
Publication date: October 2016Source:Oral Oncology, Volume 61 Author(s): Nicoleta Sinevici, Jeff O'sullivan Oral Cancer (OC) is a subset of head and neck cancer (HNC) with an annual worldwide incidence of 275,000 cases. OC remains a significant burden worldwide in terms of diagnosis, treatment and...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Toluene down-regulates filaggrin expression via the ERK and STAT3 – dependent pathways
Publication date: Available online 4 August 2016Source:Journal of Allergy and Clinical Immunology Author(s): Hana Lee, Jung Jin Shin, Hyun Cheol Bae, Woo-In Ryu, Sang Wook SonTeaser We investigated the effect of toluene on the skin barrier. The present study suggests that toluene may contribute to...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Common peptide epitopes induce cross-reactivity in hypersensitivity pneumonitis serodiagnosis
Publication date: Available online 4 August 2016Source:Journal of Allergy and Clinical Immunology Author(s): L. Millon, B. Rognon, B. Valot, C. Barrera, A.P. Bellanger, S. Roussel, J.D. Dalphin, M. Monod, G. RebouxTeaser The identification of common epitopes in orthologous immunogenic proteins from...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Detecting a fluid-filled borehole using elastic waves from a remote borehole
The interaction of a fluid-filled borehole with incident elastic waves is an important topic for downhole acoustic measurements. By analyzing the wave phenomena of this problem, one can simulate the detection of a borehole target using a source-receiver system in a remote borehole. The analysis result...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Head and neck lymphatic malformation and treatment: Clinical study of 23 cases
Publication date: Available online 3 August 2016Source:European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): J. Lerat, C. Mounayer, A. Scomparin, S. Orsel, J.-P. Bessede, K. Aubry ObjectivesHead and neck lymphatic malformation is a rare benign tumor, mainly affecting children under...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Using peak direct subglottic pressure level as an objective measure during medialization thyroplasty: a prospective study
Abstract Type I medialization thyroplasty (MT) was introduced by Isshiki more than 40 years ago. It is one of the most widely used surgical options to correct glottic insufficiency. Intraoperatively, the surgeon relies solely on perceptual subjective measures to help to achieve an optimal glottic closure...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Quantification of lymph nodes in the central compartment of the neck: a cadaveric study
Abstract Differentiated thyroid cancer (DTC) accounts for over 90 % of thyroid malignancies, and is frequently associated with central neck compartment nodal metastasis that requires a therapeutic central compartment neck dissection (CCND) for clinically evident nodes. Current knowledge on the expected...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Cardiac comorbidity in head and neck cancer patients and its influence on cancer treatment selection and mortality: a prospective cohort study
Abstract Comorbidity assessment and a profound cardiac examination were implemented into pre-treatment diagnostics to analyze their influence on head and neck squamous cell carcinoma (HNSCC) therapy selection and short-term mortality. Comorbidity was measured prospectively in 49 HNSCC patients using...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Expansion sphincter pharyngoplasty for the treatment of OSA: a systemic review and meta-analysis
Abstract This study seeks to determine the success rates of the expansion sphincter pharyngoplasty and its variants on the treatment of obstructive sleep apnea (OSA). Systematic review and meta-analysis. Two independent searches of MEDLINE, Google Scholar, Cochrane Library and Evidence Based Medicine...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
The importance of early diagnosis in patients with maxillary sinus carcinoma
Abstract There are two major challenges in the early diagnosis of maxillary sinus carcinoma: the maxillary sinus is not susceptible to direct inspection and palpation, and symptoms are uncharacteristic. The aim of this study was to assess the impact of the time interval between first symptoms noticed...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Is it safe to perform adenotonsillectomy in children with Down syndrome?
Abstract This retrospective review aims to evaluate the postoperative morbidity and mortality of 30 patients with Down syndrome who underwent adenotonsillectomy between June 2012 and December 2015 in a tertiary referral center. Mean age was 7.8 with a range of 3–12. There were 20 (66.6 %) male and ten...
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Reply to the letter to the editor “In response to: The effects of different environmental pH on healing of tympanic membrane: an experimental study” 10.1007/s00405-016-3931-7
http://ift.tt/2awAX0S
OtoRhinoLaryngology Now by Alexandros G. Sfakianakis
Monitoring of microvascular free flaps following oropharyngeal reconstruction using infrared thermography: first clinical experiences
Abstract The aim of this study is to investigate static and dynamic infrared (IR) thermography for intra- and postoperative free-flap monitoring following oropharyngeal reconstruction. Sixteen patients with oropharyngeal reconstruction by free radial forearm flap were included in this prospective, clinical...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Cranial dural permeability of inflammatory nociceptive mediators: Potential implications for animal models of migraine
Background Application of inflammatory mediators to the cranial dura has been used as a method to activate and sensitize neurons in the meningeal sensory pathway in preclinical behavioral studies of headache mechanisms. However, the relatively high concentrations and volumes used in these studies...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Specific locations of linear furrows in patients with esophageal eosinophilia
Objectives Linear furrows are the most frequently found endoscopic abnormality in affected patients, however, the precise endoscopic features remain to be fully elucidated. Here, we aimed to clarify the endoscopic features of esophageal eosinophilia (EE), essential for diagnosis of EoE, by focusing...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Vonoprazan is superior to proton pump inhibitors (PPIs) in healing artificial ulcers post-endoscopic submucosal dissection (ESD) of the stomach: a propensity score-matching analysis
Background and Aim Proton pump inhibitors (PPIs) are effective in healing artificial ulcers after endoscopic submucosal dissection (ESD) for gastric neoplasms; however, the efficacy of vonoprazan is not completely understood. The aim of this study was to determine the healing effect of vonoprazan...
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Treating reading comprehension deficits in sub-acute brain injury rehabilitation: identifying clinical practice and management
Publication date: Available online 3 August 2016Source:Journal of Communication Disorders Author(s): Kerrin Watter, Anna Copley, Emma Finch There is limited evidence for cognitive-communication reading comprehension (CCRC) interventions for adults following acquired brain injury (ABI), particularly...


Head and Neck Diseases
Protective Effect of Korean Red Ginseng On Cisplatin Ototoxicity:
Is It Effective Enough?: J Int Adv Otol. 2016 Aug 3; Authors: Olgun Y, Kırkım G, Altun Z, Aktaş S, Kolatan E, Kiray M, Bağrıyanık A, Olgun A, Kızmazoğlu DÇ, Özoğul C, Ellidokuz H, Erçetin P, Şerbetçioğlu B, Yılmaz O, Güneri EA Abstract OBJECTIVE: The aim of our study was to investigate the effects...
Head and Neck Diseases
Gout: Tophi in the Middle Ear
An Unusual Presentation of  J Int Adv Otol. 2016 Aug 3; Authors: Mutlu A, Dündar E, İşeri M, Erçin C, Cefle A Abstract Gout is a common metabolic disease and is characterized by episodic acute and chronic arthritis caused by the deposition of monosodium urate (MSU) crystals in joints and connective...
Head and Neck Diseases
Clinical features of delayed endolymphatic hydrops and intralabyrinthine schwannoma
Clinical features of delayed endolymphatic hydrops and intralabyrinthine schwannoma:Abstract Background The aim of this study was to compare the clinical history and audiovestibular function test results of patients suffering from intralabyrinthine schwannoma or delayed endolymphatic hydrops (DEH).Patients...
Head and Neck Diseases
Cranial dural permeability of inflammatory nociceptive mediators: Potential implications for animal models of migraine
Background Application of inflammatory mediators to the cranial dura has been used as a method to activate and sensitize neurons in the meningeal sensory pathway in preclinical behavioral studies of headache mechanisms. However, the relatively high concentrations and volumes used in these studies raise...
Head and Neck Diseases
Specific locations of linear furrows in patients with esophageal eosinophilia
Objectives Linear furrows are the most frequently found endoscopic abnormality in affected patients, however, the precise endoscopic features remain to be fully elucidated. Here, we aimed to clarify the endoscopic features of esophageal eosinophilia (EE), essential for diagnosis of EoE, by focusing...
Head and Neck Diseases
Vonoprazan is superior to proton pump inhibitors (PPIs) in healing artificial ulcers post-endoscopic submucosal dissection (ESD) of the stomach: a propensity score-matching analysis
Background and Aim Proton pump inhibitors (PPIs) are effective in healing artificial ulcers after endoscopic submucosal dissection (ESD) for gastric neoplasms; however, the efficacy of vonoprazan is not completely understood. The aim of this study was to determine the healing effect of vonoprazan...
Head and Neck
Ceruminous Adenocarcinoma of External Auditory Canal: A Case Report.
Related Articles Ceruminous Adenocarcinoma of External Auditory Canal: A Case Report. J Int Adv Otol. 2016 Aug 3; Authors: Bilici S, Onur F, Sünter AV, Yiğit Ö, Huq GE Abstract The external auditory canal contains ceruminous glands, which are modified apocrine sweat glands, along with sebaceous...
Head and Neck
An Unusual Presentation of Gout: Tophi in the Middle Ear.
Related Articles An Unusual Presentation of Gout: Tophi in the Middle Ear. J Int Adv Otol. 2016 Aug 3; Authors: Mutlu A, Dündar E, İşeri M, Erçin C, Cefle A Abstract Gout is a common metabolic disease and is characterized by episodic acute and chronic arthritis caused by the deposition of monosodium...
Head and Neck
Cochlear Implantation in Patient with Cochear Nerve Deficiency: A Case Report.
Related Articles Cochlear Implantation in Patient with Cochear Nerve Deficiency: A Case Report. J Int Adv Otol. 2016 Aug 3; Authors: Sürmelioğlu Ö, Tarkan Ö, Özdemir S, Tuncer Ü, Kıroğlu M, Akar Atik F Abstract Diagnostic imaging methods are very important for patients with bilateral sensourinoural...
Head and Neck
Neurofibroma around the Ear Canal: Report of Three Cases.
Related Articles Neurofibroma around the Ear Canal: Report of Three Cases. J Int Adv Otol. 2016 Aug 3; Authors: Satar B, Hıdır Y, Aşık MB, Aydın Ü, Gerek M, Yavan İ Abstract Facial nerve neurofibromas are an uncommon entity, particularly in the intraparotid region. Three cases are presented herein,...
Head and Neck
Protective Effect of Korean Red Ginseng On Cisplatin Ototoxicity: Is It Effective Enough?
Related Articles Protective Effect of Korean Red Ginseng On Cisplatin Ototoxicity: Is It Effective Enough? J Int Adv Otol. 2016 Aug 3; Authors: Olgun Y, Kırkım G, Altun Z, Aktaş S, Kolatan E, Kiray M, Bağrıyanık A, Olgun A, Kızmazoğlu DÇ, Özoğul C, Ellidokuz H, Erçetin P, Şerbetçioğlu B, Yılmaz...
Head and Neck
Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility.
Related Articles Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility. Am J Hum Genet. 2016 Aug 4;99(2):489-500 Authors: El Khouri E, Thomas L, Jeanson L, Bequignon E, Vallette B, Duquesnoy P, Montantin G, Copin B, Dastot-Le Moal F, Blanchon...
Head and Neck
Potential Curative Role of Hypericum Perforatum in an Experimental Rat Model of Tympanic Membrane Perforation.
Related Articles Potential Curative Role of Hypericum Perforatum in an Experimental Rat Model of Tympanic Membrane Perforation. J Int Adv Otol. 2016 Aug 3; Authors: Yaşar M, Kaya A, Karaman H, Kavugudurmaz M, Polat H, Sağıt M, Özcan İ Abstract OBJECTIVE: Our aim was to investigate the curative...
Head and Neck
Should Sabbath Prohibitions Be Overridden to Provide Emotional Support to a Sick Relative?
Related Articles Should Sabbath Prohibitions Be Overridden to Provide Emotional Support to a Sick Relative? Rambam Maimonides Med J. 2016;7(3) Authors: Greenberger C, Mor P Abstract BACKGROUND: There is a consensus among the halachic authorities that life-saving actions override Sabbath prohibitions....
Head and Neck
Cancer of the Throat: A Physician's Experience as a Patient.
Related Articles Cancer of the Throat: A Physician's Experience as a Patient. Rambam Maimonides Med J. 2016;7(3) Authors: Brook I Abstract The author, a practicing physician, was diagnosed with throat cancer and lost his vocal cords. He endured the side effects of radiation, repeated surgeries,...
Head and Neck
Safety of Completion Thyroidectomy for Initially Misdiagnosed Thyroid Carcinoma.
Related Articles Safety of Completion Thyroidectomy for Initially Misdiagnosed Thyroid Carcinoma. Rambam Maimonides Med J. 2016;7(3) Authors: Kranthikumar G, Syed N, Nemade H, Pawar S, Chandra Sekhara Rao LM, Subramanyeshwar Rao T Abstract INTRODUCTION: Completion thyroidectomy is defined as the...
Head and Neck
Transversus Abdominis Plane Versus Ilioinguinal and Iliohypogastric Nerve Blocks for Analgesia Following Open Inguinal Herniorrhaphy.
Related Articles Transversus Abdominis Plane Versus Ilioinguinal and Iliohypogastric Nerve Blocks for Analgesia Following Open Inguinal Herniorrhaphy. Rambam Maimonides Med J. 2016;7(3) Authors: Stav A, Reytman L, Stav MY, Troitsa A, Kirshon M, Alfici R, Dudkiewicz M, Sternberg A Abstract OBJECTIVES:...
Head and Neck
Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism.
Related Articles Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism. Rambam Maimonides Med J. 2016;7(3) Authors: Zektser M, Bartal C, Zeller L, Nevzorov R, Jotkowitz A, Stavi V, Romanyuk V, Chudakov G, Barski L Abstract OBJECTIVE:...
Head and Neck
Acrolein-an α,β-Unsaturated Aldehyde: A Review of Oral Cavity Exposure and Oral Pathology Effects.
Related Articles Acrolein-an α,β-Unsaturated Aldehyde: A Review of Oral Cavity Exposure and Oral Pathology Effects. Rambam Maimonides Med J. 2016;7(3) Authors: Aizenbud D, Aizenbud I, Reznick AZ, Avezov K Abstract Acrolein is a highly reactive unsaturated aldehyde widely present in the environment,...
Head and Neck
Remembering More Jewish Physicians.
Related Articles Remembering More Jewish Physicians. Rambam Maimonides Med J. 2016;7(3) Authors: Weisz GM, Grzybowski A Abstract The history of medicine has been an intriguing topic for both authors. The modern relevance of past discoveries led both authors to take a closer look at the lives and...
Head and Neck
Finding New Components of the Mammalian Immune System.
Related Articles Finding New Components of the Mammalian Immune System. Rambam Maimonides Med J. 2016;7(3) Authors: Beutler B Abstract The use of forward genetics to analyze mammalian biology has been dramatically accelerated by methods that make it possible instantly to determine which mutation...
Head and Neck
For Better Orchiopexy, Processus Vaginalis Should Be Dissected and a High Ligation Should Be Performed.
Related Articles For Better Orchiopexy, Processus Vaginalis Should Be Dissected and a High Ligation Should Be Performed. Rambam Maimonides Med J. 2016;7(3) Authors: Sonmez K, Karabulut R, Turkyilmaz Z, Kaya C, Pehlivan Y, Basaklar AC Abstract OBJECTIVE: Data on the prevalence of patent processus...
Head and Neck
Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility.
Related Articles Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility. Am J Hum Genet. 2016 Aug 4;99(2):489-500 Authors: El Khouri E, Thomas L, Jeanson L, Bequignon E, Vallette B, Duquesnoy P, Montantin G, Copin B, Dastot-Le Moal F, Blanchon...
Head and Neck
Should Sabbath Prohibitions Be Overridden to Provide Emotional Support to a Sick Relative?
Related Articles Should Sabbath Prohibitions Be Overridden to Provide Emotional Support to a Sick Relative? Rambam Maimonides Med J. 2016;7(3) Authors: Greenberger C, Mor P Abstract BACKGROUND: There is a consensus among the halachic authorities that life-saving actions override Sabbath prohibitions....
Head and Neck
Cancer of the Throat: A Physician's Experience as a Patient.
Related Articles Cancer of the Throat: A Physician's Experience as a Patient. Rambam Maimonides Med J. 2016;7(3) Authors: Brook I Abstract The author, a practicing physician, was diagnosed with throat cancer and lost his vocal cords. He endured the side effects of radiation, repeated surgeries,...
Head and Neck
Safety of Completion Thyroidectomy for Initially Misdiagnosed Thyroid Carcinoma.
Related Articles Safety of Completion Thyroidectomy for Initially Misdiagnosed Thyroid Carcinoma. Rambam Maimonides Med J. 2016;7(3) Authors: Kranthikumar G, Syed N, Nemade H, Pawar S, Chandra Sekhara Rao LM, Subramanyeshwar Rao T Abstract INTRODUCTION: Completion thyroidectomy is defined as the...
Head and Neck
Transversus Abdominis Plane Versus Ilioinguinal and Iliohypogastric Nerve Blocks for Analgesia Following Open Inguinal Herniorrhaphy.
Related Articles Transversus Abdominis Plane Versus Ilioinguinal and Iliohypogastric Nerve Blocks for Analgesia Following Open Inguinal Herniorrhaphy. Rambam Maimonides Med J. 2016;7(3) Authors: Stav A, Reytman L, Stav MY, Troitsa A, Kirshon M, Alfici R, Dudkiewicz M, Sternberg A Abstract OBJECTIVES:...
Head and Neck
Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism.
Related Articles Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism. Rambam Maimonides Med J. 2016;7(3) Authors: Zektser M, Bartal C, Zeller L, Nevzorov R, Jotkowitz A, Stavi V, Romanyuk V, Chudakov G, Barski L Abstract OBJECTIVE:...
Head and Neck
Acrolein-an α,β-Unsaturated Aldehyde: A Review of Oral Cavity Exposure and Oral Pathology Effects.
Related Articles Acrolein-an α,β-Unsaturated Aldehyde: A Review of Oral Cavity Exposure and Oral Pathology Effects. Rambam Maimonides Med J. 2016;7(3) Authors: Aizenbud D, Aizenbud I, Reznick AZ, Avezov K Abstract Acrolein is a highly reactive unsaturated aldehyde widely present in the environment,...
Head and Neck
Remembering More Jewish Physicians.
Related Articles Remembering More Jewish Physicians. Rambam Maimonides Med J. 2016;7(3) Authors: Weisz GM, Grzybowski A Abstract The history of medicine has been an intriguing topic for both authors. The modern relevance of past discoveries led both authors to take a closer look at the lives and...
Head and Neck
For Better Orchiopexy, Processus Vaginalis Should Be Dissected and a High Ligation Should Be Performed.
Related Articles For Better Orchiopexy, Processus Vaginalis Should Be Dissected and a High Ligation Should Be Performed. Rambam Maimonides Med J. 2016;7(3) Authors: Sonmez K, Karabulut R, Turkyilmaz Z, Kaya C, Pehlivan Y, Basaklar AC Abstract OBJECTIVE: Data on the prevalence of patent processus...
Head and Neck
Finding New Components of the Mammalian Immune System.
Related Articles Finding New Components of the Mammalian Immune System. Rambam Maimonides Med J. 2016;7(3) Authors: Beutler B Abstract The use of forward genetics to analyze mammalian biology has been dramatically accelerated by methods that make it possible instantly to determine which mutation...
Head and Neck
Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility.
Related Articles Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility. Am J Hum Genet. 2016 Aug 4;99(2):489-500 Authors: El Khouri E, Thomas L, Jeanson L, Bequignon E, Vallette B, Duquesnoy P, Montantin G, Copin B, Dastot-Le Moal F, Blanchon...
Head and Neck
Should Sabbath Prohibitions Be Overridden to Provide Emotional Support to a Sick Relative?
Related Articles Should Sabbath Prohibitions Be Overridden to Provide Emotional Support to a Sick Relative? Rambam Maimonides Med J. 2016;7(3) Authors: Greenberger C, Mor P Abstract BACKGROUND: There is a consensus among the halachic authorities that life-saving actions override Sabbath prohibitions....
Head and Neck
Cancer of the Throat: A Physician's Experience as a Patient.
Related Articles Cancer of the Throat: A Physician's Experience as a Patient. Rambam Maimonides Med J. 2016;7(3) Authors: Brook I Abstract The author, a practicing physician, was diagnosed with throat cancer and lost his vocal cords. He endured the side effects of radiation, repeated surgeries,...
Head and Neck
Safety of Completion Thyroidectomy for Initially Misdiagnosed Thyroid Carcinoma.
Related Articles Safety of Completion Thyroidectomy for Initially Misdiagnosed Thyroid Carcinoma. Rambam Maimonides Med J. 2016;7(3) Authors: Kranthikumar G, Syed N, Nemade H, Pawar S, Chandra Sekhara Rao LM, Subramanyeshwar Rao T Abstract INTRODUCTION: Completion thyroidectomy is defined as the...
Head and Neck
Transversus Abdominis Plane Versus Ilioinguinal and Iliohypogastric Nerve Blocks for Analgesia Following Open Inguinal Herniorrhaphy.
Related Articles Transversus Abdominis Plane Versus Ilioinguinal and Iliohypogastric Nerve Blocks for Analgesia Following Open Inguinal Herniorrhaphy. Rambam Maimonides Med J. 2016;7(3) Authors: Stav A, Reytman L, Stav MY, Troitsa A, Kirshon M, Alfici R, Dudkiewicz M, Sternberg A Abstract OBJECTIVES:...
Head and Neck
Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism.
Related Articles Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism. Rambam Maimonides Med J. 2016;7(3) Authors: Zektser M, Bartal C, Zeller L, Nevzorov R, Jotkowitz A, Stavi V, Romanyuk V, Chudakov G, Barski L Abstract OBJECTIVE:...
Head and Neck
Acrolein-an α,β-Unsaturated Aldehyde: A Review of Oral Cavity Exposure and Oral Pathology Effects.
Related Articles Acrolein-an α,β-Unsaturated Aldehyde: A Review of Oral Cavity Exposure and Oral Pathology Effects. Rambam Maimonides Med J. 2016;7(3) Authors: Aizenbud D, Aizenbud I, Reznick AZ, Avezov K Abstract Acrolein is a highly reactive unsaturated aldehyde widely present in the environment,...
Head and Neck
Remembering More Jewish Physicians.
Related Articles Remembering More Jewish Physicians. Rambam Maimonides Med J. 2016;7(3) Authors: Weisz GM, Grzybowski A Abstract The history of medicine has been an intriguing topic for both authors. The modern relevance of past discoveries led both authors to take a closer look at the lives and...
Head and Neck
For Better Orchiopexy, Processus Vaginalis Should Be Dissected and a High Ligation Should Be Performed.
Related Articles For Better Orchiopexy, Processus Vaginalis Should Be Dissected and a High Ligation Should Be Performed. Rambam Maimonides Med J. 2016;7(3) Authors: Sonmez K, Karabulut R, Turkyilmaz Z, Kaya C, Pehlivan Y, Basaklar AC Abstract OBJECTIVE: Data on the prevalence of patent processus...
Head and Neck
Finding New Components of the Mammalian Immune System.
Related Articles Finding New Components of the Mammalian Immune System. Rambam Maimonides Med J. 2016;7(3) Authors: Beutler B Abstract The use of forward genetics to analyze mammalian biology has been dramatically accelerated by methods that make it possible instantly to determine which mutation...
Head and Neck
Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility.
Related Articles Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility. Am J Hum Genet. 2016 Aug 4;99(2):489-500 Authors: El Khouri E, Thomas L, Jeanson L, Bequignon E, Vallette B, Duquesnoy P, Montantin G, Copin B, Dastot-Le Moal F, Blanchon...
Head and Neck
Should Sabbath Prohibitions Be Overridden to Provide Emotional Support to a Sick Relative?
Related Articles Should Sabbath Prohibitions Be Overridden to Provide Emotional Support to a Sick Relative? Rambam Maimonides Med J. 2016;7(3) Authors: Greenberger C, Mor P Abstract BACKGROUND: There is a consensus among the halachic authorities that life-saving actions override Sabbath prohibitions....
Head and Neck
Cancer of the Throat: A Physician's Experience as a Patient.
Related Articles Cancer of the Throat: A Physician's Experience as a Patient. Rambam Maimonides Med J. 2016;7(3) Authors: Brook I Abstract The author, a practicing physician, was diagnosed with throat cancer and lost his vocal cords. He endured the side effects of radiation, repeated surgeries,...
Head and Neck
Safety of Completion Thyroidectomy for Initially Misdiagnosed Thyroid Carcinoma.
Related Articles Safety of Completion Thyroidectomy for Initially Misdiagnosed Thyroid Carcinoma. Rambam Maimonides Med J. 2016;7(3) Authors: Kranthikumar G, Syed N, Nemade H, Pawar S, Chandra Sekhara Rao LM, Subramanyeshwar Rao T Abstract INTRODUCTION: Completion thyroidectomy is defined as the...
Head and Neck
Transversus Abdominis Plane Versus Ilioinguinal and Iliohypogastric Nerve Blocks for Analgesia Following Open Inguinal Herniorrhaphy.
Related Articles Transversus Abdominis Plane Versus Ilioinguinal and Iliohypogastric Nerve Blocks for Analgesia Following Open Inguinal Herniorrhaphy. Rambam Maimonides Med J. 2016;7(3) Authors: Stav A, Reytman L, Stav MY, Troitsa A, Kirshon M, Alfici R, Dudkiewicz M, Sternberg A Abstract OBJECTIVES:...
Head and Neck
Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism.
Related Articles Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism. Rambam Maimonides Med J. 2016;7(3) Authors: Zektser M, Bartal C, Zeller L, Nevzorov R, Jotkowitz A, Stavi V, Romanyuk V, Chudakov G, Barski L Abstract OBJECTIVE:...
Head and Neck
Acrolein-an α,β-Unsaturated Aldehyde: A Review of Oral Cavity Exposure and Oral Pathology Effects.
Related Articles Acrolein-an α,β-Unsaturated Aldehyde: A Review of Oral Cavity Exposure and Oral Pathology Effects. Rambam Maimonides Med J. 2016;7(3) Authors: Aizenbud D, Aizenbud I, Reznick AZ, Avezov K Abstract Acrolein is a highly reactive unsaturated aldehyde widely present in the environment,...

Medicine by Sfakianakis G. Alexandros
Correlation study between image features and mechanical properties of Han Chinese facial skin
Abstract Objective Mechanical properties are considered to be vital factors that influence skin physiology during aging. Wrinkles and skin roughness are the two main features in aged skin. The purpose of this study is to characterize the relationship between facial skin mechanical properties and...
Medicine by Sfakianakis G. Alexandros
The diagnostic performance parameters of Narrow Band Imaging: A preclinical and clinical study
Publication date: September 2016Source:Oral Oncology, Volume 60 Author(s): Giulia Ottaviani, Margherita Gobbo, Katia Rupel, Marta D'Ambros, Giuseppe Perinetti, Roberto Di Lenarda, Valentina Martinelli, Rossana Bussani, Giancarlo Tirelli, Giovanni Lodi, Serena Zacchigna, Matteo Biasotto ObjectivesThe...
Medicine by Sfakianakis G. Alexandros
The hydroxysteroid (17β) dehydrogenase family gene HSD17B12 is involved in the prostaglandin synthesis pathway, the ovarian function, and regulation of fertility
Endocrinology, Early Release. http://ift.tt/2aU4WoJ
Medicine by Sfakianakis G. Alexandros
Human eccrine sweat gland cells reconstitute polarized spheroids when subcutaneously implanted with Matrigel in nude mice
Abstract Increasing evidence indicates that maintenance of cell polarity plays a pivotal role in the regulation of glandular homeostasis and function. We examine the markers for polarity at different time points to investigate the formation of cell polarity during 3D reconstitution of eccrine sweat...
Medicine by Sfakianakis G. Alexandros
Fetal outcome and recommendations of pregnancies in lupus nephritis in the 21st century. A prospective multicenter study
Publication date: Available online 2 August 2016Source:Journal of Autoimmunity Author(s): Gabriella Moroni, Andrea Doria, Elisa Giglio, Chiara Tani, Margherita Zen, Francesca Strigini, Barbara Zaina, Angela Tincani, Federica de Liso, Caterina Matinato, Claudia Grossi, Mariele Gatto, Paola Castellana,...
Medicine by Sfakianakis G. Alexandros
Prognosis of meningiomas in the early 1970s and today
Publication date: Available online 3 August 2016Source:Clinical Neurology and Neurosurgery Author(s): Stefan Linsler, Cosima Keller, Steffi Urbschat, Ralf Ketter, Joachim Oertel ObjectiveThe benefit of the current strategy of diagnosis and treatment of meningiomas in contrast to the standard treatment...
Medicine by Sfakianakis G. Alexandros
Successful surgery in lesional epilepsy secondary to posterior quandrant ulegyria coexisting with benign childhood focal epilepsy: a case report
Publication date: Available online 3 August 2016Source:Clinical Neurology and Neurosurgery Author(s): Fengpeng Wang, Honghua Zheng, Xiaobin Zhang, Yanfang Li, Zhiying Gao, Yuanqing Wang, Xiaowei Liu, Yi Yao The present study reports, for the first time, a rare case of benign childhood focal epilepsy(BCFE)...
Medicine by Sfakianakis G. Alexandros
Prevention & treatment of obstetrical complications in APS: Is hydroxychloroquine the Holy Grail we are looking for?
Publication date: Available online 2 August 2016Source:Journal of Autoimmunity Author(s): Pier Luigi Meroni Pregnancy morbidity is part of the clinical spectrum of the anti-phospholipid syndrome (APS), with an important social and economical cost. Antiplatelet and anticoagulant agents are effective...
Medicine by Sfakianakis G. Alexandros
Valorisation of tuna processing waste biomass for recovery of functional and antioxidant peptides using enzymatic hydrolysis and membrane fractionation process
Abstract The enzymatic hydrolysis using Prolyve BS coupled to membrane process (Ultrafiltration (UF) and nanofiltration (NF)) is a means of biotransformation of tuna protein waste to Tuna protein hydrolysate (TPH) with higher added values. This method could be an effective solution for the production...
Medicine by Sfakianakis G. Alexandros
Potential ecological and human health risks of heavy metals in surface soils associated with iron ore mining in Pahang, Malaysia
Abstract The composition of heavy metals (and metalloid) in surface soils of iron ore mine-impacted areas has been evaluated of their potential ecological and human health risks. The mining areas included seven selected locations in the vicinity of active and abandoned iron ore-mining sites in Pahang,...
Medicine by Sfakianakis G. Alexandros
Des-acyl ghrelin and Ghrelin O-Acyltransferase regulate Hypothalamic-Pituitary-Adrenal axis activation and anxiety in response to acute stress
Endocrinology, Early Release. http://ift.tt/2awVhkI
Αισθητική Δερματολογία
Mechanical Properties of the Tumor Stromal Microenvironment Probed In Vitro and Ex Vivo by In Situ -Calibrated Optical Trap-Based Active Microrheology
Abstract One of the hallmarks of the malignant transformation of epithelial tissue is the modulation of stromal components of the microenvironment. In particular, aberrant extracellular matrix (ECM) remodeling and stiffening enhances tumor growth and survival and promotes metastasis. Type I collagen...
Melanoma by Alexandros G. Sfakianakis
Mechanical Properties of the Tumor Stromal Microenvironment Probed In Vitro and Ex Vivo by In Situ -Calibrated Optical Trap-Based Active Microrheology
Abstract One of the hallmarks of the malignant transformation of epithelial tissue is the modulation of stromal components of the microenvironment. In particular, aberrant extracellular matrix (ECM) remodeling and stiffening enhances tumor growth and survival and promotes metastasis. Type I collagen...
Melanoma by Alexandros G. Sfakianakis
Mechanical Properties of the Tumor Stromal Microenvironment Probed In Vitro and Ex Vivo by In Situ -Calibrated Optical Trap-Based Active Microrheology
AbstractOne of the hallmarks of the malignant transformation of epithelial tissue is the modulation of stromal components of the microenvironment. In particular, aberrant extracellular matrix (ECM) remodeling and stiffening enhances tumor growth and survival and promotes metastasis. Type I collagen is...
Medicine by Sfakianakis G. Alexandros
A hypothetical model to solve the controversy over the involvement of UCP2 in palmitate-induced β-cell dysfunction
Abstract The aim of this article is to solve an existing controversy over the involvement of uncoupling protein-2 in the impairment of glucose-stimulated insulin secretion induced by chronic exposure of β-cells to palmitate. We analyzed and compared the results of studies that support and that deny...
Medicine by Sfakianakis G. Alexandros
Synthesis and Anti-thyroid Cancer Effect of Iodo-chrysin Derivatives
A novel series of iodo-chrysin derivatives with resorcinol as raw materials were synthesized according to Baker-Venkataraman reaction and their inhibitory activities in vitro against thyroid cancer cell lines (SW-579 and TT) were evaluated by the standard methyl thiazole tetrazolium (MTT) method. Biological...
Medicine by Sfakianakis G. Alexandros
Sleep architecture in Pierre-Robin sequence: The effect of mandibular distraction osteogenesis
Publication date: October 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 89 Author(s): J.N. Bangiyev, H. Traboulsi, I. Abdulhamid, A. Rozzelle, P.J. Thottam IntroductionPierre-Robin Sequence (PRS), a triad of micro/retrognathia, glossoptosis, and upper airway obstruction,...
Medicine by Sfakianakis G. Alexandros
Molecular Basis of Familial and Sporadic Alzheimer's Disease
Alzheimer's disease (AD) is a multifactorial disease with genetic (70%) and environmental (30%) causes. Among the genetic factors are genes associated with a family history of the disease (familial AD, FAD) and sporadic AD (SAD). The genes: APP (amyloid precursor protein), PSEN1 (Presenilin 1) and PSEN2...
Medicine by Sfakianakis G. Alexandros
Hydroxyproline: A Potential Biochemical Marker and Its Role in the Pathogenesis of Different Diseases
Hydroxyproline is a non-essential amino acid found in collagen and few other extracellular animal proteins. It's two isomeric forms trans-4-hydroxy-L-proline and trans-3-hydroxy-L-proline play a crucial role in collagen synthesis and thermodynamic stability of the triple-helical conformation of collagen...
Medicine by Sfakianakis G. Alexandros
Cranial dural permeability of inflammatory nociceptive mediators: Potential implications for animal models of migraine
Background Application of inflammatory mediators to the cranial dura has been used as a method to activate and sensitize neurons in the meningeal sensory pathway in preclinical behavioral studies of headache mechanisms. However, the relatively high concentrations and volumes used in these studies...
Medicine by Sfakianakis G. Alexandros
Ceruminous Adenocarcinoma of External Auditory Canal: A Case Report.
Related Articles Ceruminous Adenocarcinoma of External Auditory Canal: A Case Report. J Int Adv Otol. 2016 Aug 3; Authors: Bilici S, Onur F, Sünter AV, Yiğit Ö, Huq GE Abstract The external auditory canal contains ceruminous glands, which are modified apocrine sweat glands, along with sebaceous...
Medicine by Sfakianakis G. Alexandros
Protective Effect of Korean Red Ginseng On Cisplatin Ototoxicity: Is It Effective Enough?
Related Articles Protective Effect of Korean Red Ginseng On Cisplatin Ototoxicity: Is It Effective Enough? J Int Adv Otol. 2016 Aug 3; Authors: Olgun Y, Kırkım G, Altun Z, Aktaş S, Kolatan E, Kiray M, Bağrıyanık A, Olgun A, Kızmazoğlu DÇ, Özoğul C, Ellidokuz H, Erçetin P, Şerbetçioğlu B, Yılmaz...
Medicine by Sfakianakis G. Alexandros
Cochlear Implantation in Patient with Cochear Nerve Deficiency: A Case Report.
Related Articles Cochlear Implantation in Patient with Cochear Nerve Deficiency: A Case Report. J Int Adv Otol. 2016 Aug 3; Authors: Sürmelioğlu Ö, Tarkan Ö, Özdemir S, Tuncer Ü, Kıroğlu M, Akar Atik F Abstract Diagnostic imaging methods are very important for patients with bilateral sensourinoural...
Medicine by Sfakianakis G. Alexandros
Neurofibroma around the Ear Canal: Report of Three Cases.
Related Articles Neurofibroma around the Ear Canal: Report of Three Cases. J Int Adv Otol. 2016 Aug 3; Authors: Satar B, Hıdır Y, Aşık MB, Aydın Ü, Gerek M, Yavan İ Abstract Facial nerve neurofibromas are an uncommon entity, particularly in the intraparotid region. Three cases are presented herein,...
Medicine by Sfakianakis G. Alexandros
Oscillatory Characteristics of the Vocal Folds Across the Tenor Passaggio
Recent research has revealed that classically trained tenors tend to constrict epilaryngeal structures when singing in and above the passaggio (ie, the frequency region where register events typically occur). These constrictions complicate visibility of vocal fold oscillatory patterns with transoral...
Medicine by Sfakianakis G. Alexandros
Evaluation of the acoustic (stapedius) reflex test in children and adolescents with peripheral facial nerve palsy
The stapedius nerve is one of the branches of the facial nerve in the temporal bone. It supplies the stapedius muscle, which is responsible for the attenuation reflex that protects the inner ear from loud noises. The stapedius (acoustic) reflex (SR) test is useful in identifying the site of facial nerve...
Medicine by Sfakianakis G. Alexandros
Potential Curative Role of Hypericum Perforatum in an Experimental Rat Model of Tympanic Membrane Perforation.
Related Articles Potential Curative Role of Hypericum Perforatum in an Experimental Rat Model of Tympanic Membrane Perforation. J Int Adv Otol. 2016 Aug 3; Authors: Yaşar M, Kaya A, Karaman H, Kavugudurmaz M, Polat H, Sağıt M, Özcan İ Abstract OBJECTIVE: Our aim was to investigate the curative...
Medicine by Sfakianakis G. Alexandros
Human Adipose-Derived Stem Cells Delay Retinal Degeneration in Royal College of Surgeons Rats Through Anti-Apoptotic and VEGF-Mediated Neuroprotective Effects
Stem cell therapy is a promising therapeutic approach for retinal degeneration (RD). Our study investigated the effects of human adipose derived stem cell (hADSCs) on Royal College of Surgeons (RCS) rats. </p> <p> Methods: Green fluorescent protein (GFP)-labeled hADSCs were transplanted subretinally...
Medicine by Sfakianakis G. Alexandros
Diabetes and Complications: Cellular Signaling Pathways, Current Understanding and Targeted Therapies
Diabetes is a metabolic disorder and over the past decades, it has become a major cause of morbidity and mortality affecting the youth and middle-aged as it is the fourth leading cause of disease related to death. In both type 1 and type 2 diabetes the severe pathogenesis cause micro vascular complications:...
Medicine by Sfakianakis G. Alexandros
Pediatric tracheostomy: Survival and long-term outcomes
Publication date: October 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 89 Author(s): Norihiko Tsuboi, Kentaro Ide, Nao Nishimura, Satoshi Nakagawa, Noriko Morimoto ObjectivesThe objective of this study was to investigate if there were any differences in survival and long-term...
Medicine by Sfakianakis G. Alexandros
Radiation exposure from videofluoroscopic swallow studies in children with a type 1 laryngeal cleft and pharyngeal dysphagia: A retrospective review
Publication date: October 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 89 Author(s): Cheryl Hersh, Carissa Wentland, Sarah Sally, Marie de Stadler, Steven Hardy, M. Shannon Fracchia, Bob Liu, Christopher Hartnick IntroductionRadiation exposure is recognized as having...
Medicine by Sfakianakis G. Alexandros
Supplement: Eyelid reconstruction using a hard palate mucoperiosteal graft combined with a V-Y subcutaneously pedicled flap
We previously used a hard palate mucoperiosteal graft combined with a curved V-Y subcutaneously pedicled flap for reconstruction of full-thickness eyelid defect1-3). We reported the use of this technique in four cases of malignant skin tumours1) and four cases of artificial eye socket contractures2)....
Medicine by Sfakianakis G. Alexandros
The influence of human papillomavirus on nasopharyngeal carcinoma in Japan
Although Japan is a non-endemic area with nasopharyngeal carcinoma (NPC), the proportion of WHO type I NPC in Japan are different from that in non-endemic areas such as North America and Europe. Recently, it is said that not only Epstein–Barr virus (EBV) but also human papillomavirus (HPV) has an influence...
Medicine by Sfakianakis G. Alexandros
Panorama
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Medicine by Sfakianakis G. Alexandros
Numerical modeling of the traction process in the treatment for Pierre-Robin Sequence
Publication date: October 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 89 Author(s): Jakub J. Słowiński, Aleksandra Czarnecka IntroductionThe goal of this numerical study was to identify the results of modulated growth simulation of the mandibular bone during traction...
Medicine by Sfakianakis G. Alexandros
An Unusual Presentation of Gout: Tophi in the Middle Ear.
Related Articles An Unusual Presentation of Gout: Tophi in the Middle Ear. J Int Adv Otol. 2016 Aug 3; Authors: Mutlu A, Dündar E, İşeri M, Erçin C, Cefle A Abstract Gout is a common metabolic disease and is characterized by episodic acute and chronic arthritis caused by the deposition of monosodium...
Medicine by Sfakianakis G. Alexandros
A novel method for evaluation of oxidative stress in children with OSA
Publication date: October 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 89 Author(s): Fatih Gul, Togay Muderris, Gokhan Yalciner, Halil Ibrahim Mise, Yagmur Canan, Mehmet Ali Babademez, Ozcan Erel ObjectivesTo evaluate the role of adenotonsillar hypertrophy and the outcomes...
Medicine by Sfakianakis G. Alexandros
Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility.
Related Articles Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility. Am J Hum Genet. 2016 Aug 4;99(2):489-500 Authors: El Khouri E, Thomas L, Jeanson L, Bequignon E, Vallette B, Duquesnoy P, Montantin G, Copin B, Dastot-Le Moal F, Blanchon...
Medicine by Sfakianakis G. Alexandros
Editorial Board
Publication date: September 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 88 http://ift.tt/2aZHnIj
Medicine by Sfakianakis G. Alexandros
Association of urinary melatonin levels and aging-related outcomes in older men
• Urinary melatonin levels, measured at a single point in later life, were not associated with cognitive or physical function in this cohort of older men.• These melatonin levels also were not related to mortality, including cardiovascular-related mortality, in this cohort.• Further research should explore...

Cancer
Mechanical Properties of the Tumor Stromal Microenvironment Probed In Vitro and Ex Vivo by In Situ -Calibrated Optical Trap-Based Active Microrheology
Abstract One of the hallmarks of the malignant transformation of epithelial tissue is the modulation of stromal components of the microenvironment. In particular, aberrant extracellular matrix (ECM) remodeling and stiffening enhances tumor growth and survival and promotes metastasis. Type I collagen...
Cancer
Preclinical Pharmacokinetics and Biodistribution Studies of 89Zr-labeled Pembrolizumab
Pembrolizumab is a humanized monoclonal antibody targeting programmed cell death protein 1 (PD-1) found on T and pro-B cells. Pembrolizumab prevents PD-1 ligation by both PD-L1 and PD-L2, preventing the immune dysregulation that otherwise occurs when T-cells encounter cells expressing these ligands....
Cancer by Sfakianakis G.Alexandros
Lung metastasis of colorectal cancer through CCL15-CCR1 axis
Purpose: We have reported loss of SMAD4 promotes expression of CCL15 from colorectal cancer (CRC) to recruit CCR1+ myeloid cells through the CCL15-CCR1 axis, which contributes to invasion and liver metastasis. However, the molecular mechanism of lung metastasis is yet to be elucidated. Our purpose is...
Cancer by Sfakianakis G.Alexandros
p65/FOXM1/{beta}-catenin in CML stem cells
Purpose:Leukemia stem cells (LSCs), which are insensitive to tyrosine kinase inhibitors (TKIs), are an important source of TKI resistance and disease relapse in chronic myelogenous leukemia (CML). Obstacles to eradicating LSCs include limited understanding of the regulation network of LSCs. The present...
Cancer
Successful therapy of Candida pulcherrima fungemia in a premature newborn with liposomal amphotericin B and micafungin
Publication date: Available online 3 August 2016Source:Medical Mycology Case Reports Author(s): Alexandra Mpakosi, Maria Siopi, Vasiliki Falaina, Nikolaos Siafakas, Emmanuel Roilides, Maria Kimouli, Martha Theodoraki, Paraskevi Karle, Joseph Meletiadis New Candida species may cause bloodstream infections...
Cancer
Successfultreatment of cutaneous protothecosis with liposomal amphotericin and oral itraconazole
Publication date: Available online 3 August 2016Source:Medical Mycology Case Reports Author(s): Brendan McMullan, Simon Pollett, Chayanika Biswas, Donald Packham Protothecosis is a rare algal infection, affecting primarily immunocompromised hosts. Optimal management is unclear: in-vitro antimicrobial...
Cancer
The invisible basal cell carcinoma: how reflectance confocal microscopy improves the diagnostic accuracy of clinically unclear facial macules and papules
Abstract Difficult to diagnose and early non-melanoma skin cancer lesions are frequently seen in daily clinical practice. Besides precancerous lesions such as actinic keratosis, basal cell carcinomas (BCCs) score the highest frequency in skin tumors. While infiltrative and nodular BCCs require a surgical...
Cancer
MEK inhibitor-associated retinopathy (MEKAR) in metastatic melanoma: Long-term ophthalmic effects
Publication date: September 2016Source:European Journal of Cancer, Volume 65 Author(s): U. Urner-Bloch, M. Urner, N. Jaberg-Bentele, A.L. Frauchiger, R. Dummer, S.M. Goldinger BackgroundMitogen-activated protein kinase kinase (MEK) inhibitors have aroused considerable interest in oncology. Activity...
Cancer by Sfakianakis Alexandros
Cancer in Europe: Death sentence or life sentence?
Publication date: September 2016Source:European Journal of Cancer, Volume 65 Author(s): Lifang Liu, Peter O'Donnell, Richard Sullivan, Alexander Katalinic, Lotte Moser, Angela de Boer, Francoise Meunier With so many adults and children receiving successful treatment for their cancer, survivorship is...
Cancer by Sfakianakis Alexandros
Demand for radiotherapy in Spain
Abstract Aim Assessing the demand for radiotherapy in Spain based on existing evidence to estimate the human resources and equipment needed so that every person in Spain has access to high-quality radiotherapy when they need it. Material and methods We used data from the European Cancer Observatory...
Cancer by Sfakianakis Alexandros
Salvage treatment with irinotecan/cisplatin versus pemetrexed/cisplatin in patients with non-small cell lung cancer pre-treated with a non-platinum-based regimen in the first-line setting: a randomized phase II study of the Hellenic Oncology Research Group (HORG)
Abstract Background Platinum-based chemotherapy is the standard front-line treatment for patients with advanced non-small cell lung cancer (NSCLC). However, non-platinum combinations of third-generation chemotherapeutic agents are considered an alternative therapeutic option for patients who cannot...
Cancer by Sfakianakis Alexandros
The Pharmacological Costs of Complete Liver Resections in Unselected Advanced Colorectal Cancer Patients: Focus on Targeted Agents. A Review of Randomized Clinical Trials
Abstract Background The aim of this study was to evaluate the pharmacological costs of conversion chemotherapy with targeted biological agents in an unselected population of advanced colorectal cancer (CRC) patients in order to achieve an R0 liver resection. Methods Full reports and updates of randomized...
Cancer by Sfakianakis Alexandros
UNC119 mediates gambogic acid-induced cell-cycle dysregulation through the Gsk3[beta]/[beta]-catenin pathway in hepatocellular carcinoma cells.
UNC119 (uncoordinated 119 or retinal protein 4), specifically expressed in the photoreceptors in the retina, has recently been found to be upregulated in hepatocellular carcinoma (HCC) tissues, predicting a poor prognosis. However, the biological role of UNC119 in cancer treatment is still poorly understood....
Cancer by Sfakianakis Alexandros
Reactive oxygen species contribute toward Smac mimetic/temozolomide-induced cell death in glioblastoma cells .
Small-molecule inhibitors of Inhibitor of Apoptosis proteins such as Smac mimetics have been reported to provide a promising tool to sensitize glioblastoma (GBM) cells to cytotoxic therapies including chemotherapeutic drugs. However, the underlying molecular mechanisms of action have not yet been fully...
Cancer
MicroRNA-15a inhibits the growth and invasiveness of malignant melanoma and directly targets on CDCA4 gene
Abstract MicroRNAs can affect behaviors of tumor cells by modulating the expression of the target genes that involve tumor growth, invasiveness, and death. The goal of this research is to examine the effects of miR-15a on the proliferation and invasiveness of malignant melanoma cells in vitro, as well...
Cancer by Sfakianakis Alexandros
Suberanilohydroxamic acid (vorinostat) synergistically enhances the cytotoxicity of doxorubicin and cisplatin in osteosarcoma cell lines.
Osteosarcoma is the most common primary bone cancer in children and is a highly malignant disease, in which 25% of patients present with metastasis at diagnosis. Considerable advances in the treatment of localized disease have been achieved since the introduction of combined modality treatment, increasing...
Cancer by Sfakianakis Alexandros
Race and mortality risk after radiation therapy in men treated with or without androgen-suppression therapy for favorable-risk prostate cancer
BACKGROUND African American (AA) men are more likely than non-AA men to have a comorbid illness that could interact with androgen-deprivation therapy (ADT) and shorten survival. This study assessed the impact that race had on the risk of all-cause mortality (ACM) and other-cause mortality (OCM)...
Cancer by Sfakianakis Alexandros
FDA approves several diagnostic tests for cancer
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Cancer by Sfakianakis Alexandros
NCI seeks ideas for National Cancer Moonshot
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Cancer by Sfakianakis Alexandros
Publication Schedule
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Cancer by Sfakianakis Alexandros
High fruit intake, lower alcohol consumption associated with lower breast cancer risk
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Cancer
Complex odontomas hindering eruption of maxillary permanent teeth: a radiological perspective
Description Odontomas are benign neoplasms of odontogenic origin. They are more appropriately termed hamartomas because of their limited growth potential rather than true neoplasm. Clinically, three types of odontomas are identified in the literature: central (intraosseous) odontoma, peripheral (extraosseous...
Cancer by Sfakianakis Alexandros
Social Media and Internet Resources for Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Abstract The incorporation of Internet resources and the use of social media among patients, clinicians, advocates, and researchers in the field of hematology and oncology are growing in importance. Utilization of online information sharing is rising, especially among those involved in rare blood cancer...
Cancer by Sfakianakis Alexandros
Social Media and Myeloproliferative Neoplasms (MPN): Analysis of Advanced Metrics From the First Year of a New Twitter Community: #MPNSM
Abstract The social media platform Twitter has provided the hematology/oncology community with unprecedented, novel methods of interpersonal communication and increased ability for the dissemination of important updates in a rapidly moving field. The advent, and subsequent success, of disease-specific...
Cancer by Sfakianakis Alexandros
A longitudinal study of patients with cirrhosis treated with L-ornithine L-aspartate, examined with magnetization transfer, diffusion-weighted imaging and magnetic resonance spectroscopy
Abstract The presence of overt hepatic encephalopathy (HE) is associated with structural, metabolic and functional changes in the brain discernible by use of a variety of magnetic resonance (MR) techniques. The changes in patients with minimal HE are less well documented. Twenty-two patients with well-compensated...
Cancer by Sfakianakis Alexandros
Association between nutritional status, inflammatory condition, and prognostic indexes with postoperative complications and clinical outcome of patients with gastrointestinal neoplasia.
Association between nutritional status, inflammatory condition, and prognostic indexes with postoperative complications and clinical outcome of patients with gastrointestinal neoplasia. Nutr Cancer. 2016 Aug 2;:1-7 Authors: Costa MD, Vieira de Melo CY, Amorim AC, Cipriano Torres DO, Dos Santos AC...
Cancer by Sfakianakis Alexandros
Effect of hydration status on atrial and ventricular volumes and function in healthy adult volunteers
Abstract Background Assessment of cardiac chamber volumes is a fundamental part of cardiac magnetic resonance (CMR) imaging. While the effects of inter- and intraobserver variability have been studied and have a recognized effect on the comparability of serial cardiac MR imaging studies, the effect...
Cancer by Sfakianakis Alexandros
Characteristic calcaneal ossification: an additional early radiographic finding in infants with fibrodysplasia ossificans progressiva
Abstract Background We have clinically encountered children with fibrodysplasia ossificans progressiva who had abnormal calcaneal ossification. Objective To evaluate whether calcaneal ossification variants are significant radiographic findings in children with fibrodysplasia ossificans progressiva....
Cancer by Sfakianakis Alexandros
Extracellular HSP70-peptide complexes promote the proliferation of hepatocellular carcinoma cells via TLR2/4/JNK1/2MAPK pathway
Abstract Heat shock protein 70 (HSP70) and HSP70-peptide complexes (HSP70-PCs) have been implicated in the pathogenesis of multiple tumors in humans and have been experimentally shown to increase the proliferation of cell lines derived from hepatocellular carcinoma. The goal of this study was to elucidate...
Cancer by Sfakianakis Alexandros
MicroRNA-15a inhibits the growth and invasiveness of malignant melanoma and directly targets on CDCA4 gene
Abstract MicroRNAs can affect behaviors of tumor cells by modulating the expression of the target genes that involve tumor growth, invasiveness, and death. The goal of this research is to examine the effects of miR-15a on the proliferation and invasiveness of malignant melanoma cells in vitro, as well...
Cancer by Sfakianakis Alexandros
Disruption of clock gene expression in human colorectal liver metastases
Abstract The circadian timing system controls about 40 % of the transcriptome and is important in the regulation of a wide variety of biological processes including metabolic and proliferative functions. Disruption of the circadian clock could have significant effect on human health and has an important...
Cancer by Sfakianakis Alexandros
Fibroblast activation protein alpha is expressed by transformed and stromal cells and is associated with mesenchymal features in glioblastoma
Abstract Glioblastomas are deadly neoplasms resistant to current treatment modalities. Fibroblast activation protein (FAP) is a protease which is not expressed in most of the normal adult tissues but is characteristically present in the stroma of extracranial malignancies. FAP is considered a potential...
Cancer
Prevention as Precipitant
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors' commentary follows. Stage. A 72-year-old man was admitted… from...
Cancer
IJMS, Vol. 17, Pages 1267: Challenges in Translating GWAS Results to Clinical Care
Clinical genetic testing for Mendelian disorders is standard of care in many cases; however, it is less clear to what extent and in which situations clinical genetic testing may improve preventive efforts, diagnosis and/or prognosis of complex disease. One challenge is that much of the reported research...        
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