The cleaning efficacy of laser-activated irrigation with pulsed erbium lasers
Influence of lasing parameters on the cleaning efficacy of laser-activated irrigation with pulsed erbium lasers: AbstractLaser-activated irrigation (LAI) using erbium lasers is an irrigant agitation technique with great potential for improved cleaning of the root canal system, as shown in many in vitro studies. However, lasing parameters for LAI vary considerably and their influence remains unclear. Therefore, this study sought to investigate the influence of pulse energy, pulse frequency, pulse length, irradiation time and fibre tip shape, position and diameter on the cleaning eff... περισσότερα »
Action of antimicrobial photodynamic therapy on heterotypic biofilm: Candida albicans and Bacillus atrophaeus
Action of antimicrobial photodynamic therapy on heterotypic biofilm: Candida albicans and Bacillus atrophaeus: AbstractThe increase in survival and resistance of microorganisms organized in biofilms demonstrates the need for new studies to develop therapies able to break this barrier, such as photodynamic therapy, which is characterized as an alternative, effective, and non-invasive treatment. The objective was to evaluate in vitro the effect of antimicrobial photodynamic therapy on heterotypic biofilms of *Candida albicans* and *Bacillus atrophaeus* using rose bengal (12.5 μM) and... περισσότερα »
Local heating of the wound with dressings soaked in saline at 42°C can reduce postoperative bleeding: a single-blind, split-mouth, randomised controlled clinical trial
Local heating of the wound with dressings soaked in saline at 42°C can reduce postoperative bleeding: a single-blind, split-mouth, randomised controlled clinical trial: Control of bleeding is essential during oral procedures. Although various chemical agents have been introduced and tested, hot water dressing has not to our knowledge been assessed before. Studies of operations for epistaxis or sinus conditions have suggested that irrigation with hot water can reduce bleeding, so we hypothesised that it might be effective in reducing bleeding after extraction too. Ten patients who re... περισσότερα »
Osteoarthrosis of the temporomandibular joint
Rabbit model for osteoarthrosis of the temporomandibular joint as a basis for assessment of outcomes after intervention: Osteoarthritis can be induced in the temporomandibular joint (TMJ) by primary or secondary trauma, or overloading of the joint. We have therefore systematically evaluated the histological progression of experimental osteoarthritis induced by a high concentration of monosodium iodoacetate into the rabbit TMJ. These findings may contribute to the establishment of a protocol to investigate the benefits of treatment of osteoarthritis of the TMJ. We used 21 male New Ze... περισσότερα »
Apoptosis is one of the major mechanisms of photodynamic therapy (PDT) that leads to tumor degradation
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
Time course of apoptosis induced by photodynamic therapy with PsD007 in LT12 acute myeloid leukemia cells: AbstractApoptosis is one of the major mechanisms of photodynamic therapy (PDT) that leads to tumor degradation. Apoptosis-related genes and proteins function in a certain order and timing in the complex network of apoptosis. To further understanding of the apoptotic mechanism of PDT, this research examined the time course of apoptosis from PsD007 (a second-generation photosensitizer developed in China) induced PDT on the rat acute myeloid leukemia cell line LT12. MTT was used ... περισσότερα »
Elevated VEGFA mRNA levels in oral squamous cell carcinomas and tumor margins: a preliminary study
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
Elevated VEGFA mRNA levels in oral squamous cell carcinomas and tumor margins: a preliminary study: Background New blood vessel formation events are essential for tumor clonal expansion and progression. Despite the importance of vascular endothelial growth factor A (VEGFA) for tumor angiogenesis, few studies have evaluated the expression profile of this gene in oral squamous cell carcinoma (OSCC) and tumor margins (TM). This study aimed to evaluate the expression of the VEGFA gene and its protein in OSCC and TM. Methods Gene expression was evaluated in cryopreserved samples of OSCCs... περισσότερα »
Elevated VEGFA mRNA levels in oral squamous cell carcinomas and tumor margins: a preliminary study
Elevated VEGFA mRNA levels in oral squamous cell carcinomas and tumor margins: a preliminary study: Background New blood vessel formation events are essential for tumor clonal expansion and progression. Despite the importance of vascular endothelial growth factor A (VEGFA) for tumor angiogenesis, few studies have evaluated the expression profile of this gene in oral squamous cell carcinoma (OSCC) and tumor margins (TM). This study aimed to evaluate the expression of the VEGFA gene and its protein in OSCC and TM. Methods Gene expression was evaluated in cryopreserved samples of OSCCs... περισσότερα »
A non-invasive magnetic resonance imaging-based model predicts portal venous pressure
A non-invasive magnetic resonance imaging-based model predicts portal venous pressure: AIM To establish a non-invasive model for the assessment of portal venous pressure (PVP) based on the magnetic resonance imaging (MRI) parameters. METHODS In this prospective, Ethics Committee-approved study, contrast-enhanced MRI scanning was performed on 109 patients indicated for upper abdominal surgeries after written consents obtained, and intraoperative PVP measurement was completed in 92 patients. Seventeen patients were excluded for not undergoing surgery or unsuccessful catheterization. A...περισσότερα »
High-resolution manometric subtypes.Pneumatic balloon dilatation (PD) and laparoscopic Heller myotomy (LHM) in patients with achalasia.
High-resolution manometric subtypes as a predictive factor for the treatment of achalasia: a meta-analysis and systematic review: Abstract Aim This study assessed manometric subtypes as predictive factors for the treatment efficacies of pneumatic balloon dilatation (PD) and laparoscopic Heller myotomy (LHM) in patients with achalasia. Methods A systematic search of the Cochrane Library Central database, PubMed and Embase was conducted to identify relevant publications on high-resolution manometric subtypes and different therapies for achalasia with predefined inclusion and exclusion...περισσότερα »
Primary gastric neuroendocrine neoplasms
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Clinicopathological features of primary gastric neuroendocrine neoplasms: a single-center analysis: Abstract Objective Few studies have sought to characterize the clinical features of gastric neuroendocrine neoplasms (GNENs) among the Chinese population. This study aimed to profile the clinical characteristics, diagnosis and therapeutic modalities for GNENs among the Chinese population. Methods Data pertaining to 57 patients with GNENs, who were diagnosed between 1995 and 2015 at the Peking Union Medical College Hospital, were retrospectively analyzed. All GNENs cases were histologi...περισσότερα »
Distortion product otoacoustic emission generation mechanisms and their dependence on stimulus level and primary frequency ratio
Distortion product otoacoustic emission generation mechanisms and their dependence on stimulus level and primary frequency ratio: In this study, a systematic analysis of the dependence on stimulus level and primary frequency ratio r of the different components of human distortion product otoacoustic emissions has been performed, to check the validity of theoretical models of their generation, as regards the localization of the sources and the relative weight of distortion and reflection generation mechanisms. 2f1 – f2 and 2f2 – f1 distortion product otoacoustic emissions of 12 norm... περισσότερα »
The benefit of head orientation to speech intelligibility in noise
The benefit of head orientation to speech intelligibility in noise: Spatial release from masking is traditionally measured with speech in front. The effect of head-orientation with respect to the speech direction has rarely been studied. Speech-reception thresholds (SRTs) were measured for eight head orientations and four spatial configurations. Benefits of head orientation away from the speech source of up to 8 dB were measured. These correlated with predictions of a model based on better-ear listening and binaural unmasking (r = 0.96). Use of spontaneous head orientations was mea... περισσότερα »
The measurement of formant frequencies of vowels is among the most common measurements in speech studies, but measurements are known to be biased by the particular fundamental frequency (F0) exciting the formants
Comparing measurement errors for formants in synthetic and natural vowelsa): The measurement of formant frequencies of vowels is among the most common measurements in speech studies, but measurements are known to be biased by the particular fundamental frequency (F0) exciting the formants. Approaches to reducing the errors were assessed in two experiments. In the first, synthetic vowels were constructed with five different first formant (F1) values and nine different F0 values; formant bandwidths, and higher formant frequencies, were constant. Input formant values were compared to ...περισσότερα »
Esophagectomy:Three-field Versus Two-field Lymphadenectomy
Esophagectomy:Three-field Versus Two-field Lymphadenectomy: *Condition*: Esophageal Neoplasms *Intervention*: Procedure: Lymphadenectomy *Sponsor*: Fudan University Esophageal carcinoma is an aggressive disease with a poor prognosis. Surgical resection with radical lymphadenectomy remains the basic method of management of this malignancy. Lymph node metastasis is one of the most important factors in predicting the prognosis of patients with esophageal carcinoma, but the extent of lymph node dissection is still in debate, and there is no statistical evidence based on large s...περισσότερα »
Distortion Product After Stapedotomy Surgery
Distortion Product After Stapedotomy Surgery: *Condition*: Distorted Sound Perception *Intervention*: *Sponsors*: University of Zurich; Swiss National Science Foundation If the stapes footplate is fixed in position, e.g. by otosclerosis, rather than being normally mobile, a conductive hearing loss results. This conductive hearing loss is usually compensated with hearing aids or through stapedotomy. During stapedotomy, the diseased stapes bone is removed and is replaced with a piston prosthesis that conveys the sound stimulus from the incus to the footplate of the removed... περισσότερα »
Induction chemotherapy-based larynx preservation program for locally advanced hypopharyngeal cancer: oncologic and functional outcomes and prognostic factors
Induction chemotherapy-based larynx preservation program for locally advanced hypopharyngeal cancer: oncologic and functional outcomes and prognostic factors: AbstractTo evaluate oncologic and functional outcomes and prognostic factors in patients with locally advanced hypopharyngeal cancer included in an induction chemotherapy (ICT)-based larynx preservation program in daily clinical practice. All patients with locally advanced (T3/4, N0–3, M0) hypopharyngeal squamous cell carcinoma, technically suitable for total pharyngo-laryngectomy, treated by docetaxel (75 mg/m2, day 1), cisp... περισσότερα »
Migraine and Obesity
Behavioral Weight Loss Treatments for Individuals with Migraine and Obesity: AbstractMigraine and obesity are each prevalent disorders involving significant personal and societal burden. Epidemiologic research demonstrates a link between migraine and obesity that is further substantiated by putative behavioral, psychosocial, and physiological mechanisms. As obesity is considered a modifiable risk factor for exacerbation of migraine, weight loss may be a particularly useful treatment option for people with comorbid migraine and obesity. Behavioral weight loss interventions compleme... περισσότερα »
Planning Treatment for Oesophago-gastric Cancer: a Maintenance Therapy Trial
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Planning Treatment for Oesophago-gastric Cancer: a Maintenance Therapy Trial: *Conditions*: Adenocarcinoma of the Oesophagus; Adenocarcinoma of the Gastro-oesophageal Junction; Adenocarcinoma of the Stomach *Interventions*: Drug: Capecitabine; Drug: MEDI4736; Drug: Trastuzumab *Sponsors*: Royal Marsden NHS Foundation Trust; MedImmune LLC ArmsAssigned Interventions No Intervention: A1: Surveillance Patients in this Arm will follow current UK standard of care for this setting and will be reviewed every 4 weeks Experimental: Arm A2: Capecitabine Maintenance 1250 mg/M2/...περισσότερα »
Cisplatin Combined With S-1 or Paclitaxel as First-line Treatment for Metastatic Esophageal Squamous Cell Carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Cisplatin Combined With S-1 or Paclitaxel as First-line Treatment for Metastatic Esophageal Squamous Cell Carcinoma: *Condition*: Esophageal Squamous Cell Carcinoma *Interventions*: Drug: Cisplatin Combined With S-1; Drug: Cisplatin Combined With Paclitaxel *Sponsor*: Fudan University ArmsAssigned Interventions Experimental: Cisplatin Combined With S-1 Cisplatin 75mg/m2 ivgtt d1 S-1 BSA＜1.5 50mg bid，BSA≥1.5 60mg bid po d1-14 Drug: Cisplatin Combined With S-1 Experimental: Cisplatin Combined With Paclitaxel Cisplatin 75mg/m2 ivgtt d1 Paclitaxel 175mg/m2 d1 ivgtt 3h Drug: Cisp...περισσότερα »
Induction chemotherapy-based larynx preservation program for locally advanced hypopharyngeal cancer: oncologic and functional outcomes and prognostic factors
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Induction chemotherapy-based larynx preservation program for locally advanced hypopharyngeal cancer: oncologic and functional outcomes and prognostic factors: AbstractTo evaluate oncologic and functional outcomes and prognostic factors in patients with locally advanced hypopharyngeal cancer included in an induction chemotherapy (ICT)-based larynx preservation program in daily clinical practice. All patients with locally advanced (T3/4, N0–3, M0) hypopharyngeal squamous cell carcinoma, technically suitable for total pharyngo-laryngectomy, treated by docetaxel (75 mg/m2, day 1), cisp... περισσότερα »
Metabolic Syndrome and Olfactory Dysfunction
Gender Difference in the Epidemiological Association between Metabolic Syndrome and Olfactory Dysfunction: The Korea National Health and Nutrition Examination Survey: by Se-Hwan Hwang, Jun-Myung Kang, Jae-Hyun Seo, Kyung-do Han, Young-Hoon Joo Metabolic syndrome (MetS) is associated with a higher risk of morbidity and/or mortality for various chronic diseases. The aim of this study was to investigate the relationships of MetS and its components with olfactory dysfunction in a representative Korean population. We analyzed the data from the Korean National Health and Nutrition Examin...περισσότερα »
Pediatric Desmoid Fibromatosis of the Parapharyngeal Space
: A Case Report and Review of Literature via American Journal of Otolaryngology Publication date: Available online 9 February 2016 *Source:*American Journal of Otolaryngology Author(s): Zhong Zheng, Adrienne C. Jordan, Alyssa M. Hackett, Raymond L. Chai Desmoid fibromatosis, or aggressive fibromatosis, is a benign but locally infiltrative fibroblastic neoplasm arising from fascial or musculoaponeurotic tissues. Although lacking metastatic potential, head and neck fibromatosis can have significant functional or cosmetic morbidities. 7-15% of all desmoid tumors are seen in the head and n... περισσότερα »
Adenoid Cystic Carcinoma of the External Ear
: A Population Based Study via American Journal of Otolaryngology Publication date: Available online 8 February 2016 *Source:*American Journal of Otolaryngology Author(s): Ross W. Green, Uchechukwu C. Megwalu PurposeTo determine the incidence of adenoid cystic carcinoma of the external ear in the United States, and to evaluate the clinical characteristics and survival outcomes associated with the disease.Materials and MethodsData were extracted from the Surveillance, Epidemiology, and End Results (SEER) 18 Database of the National Cancer Institute. The study cohort included patients di... περισσότερα »
Eyelid and brow asymmetry in patients evaluated for upper lid blepharoplasty
Eyelid and brow asymmetry in patients evaluated for upper lid blepharoplasty Kristian I MacdonaldEmail author, Adrian I Mendez, Robert D Hart and S Mark Taylor Journal of Otolaryngology - Head & Neck Surgery201443:36 DOI: 10.1186/s40463-014-0036-4© Macdonald et al.; licensee BioMed Central Ltd. 2014 Received: 29 May 2014Accepted: 24 August 2014Published: 2 October 2014 Abstract Introduction In evaluation for blepharoplasty, patients often desire improved cosmesis and/or correction of visual field deficits. However, patients are usually unaware of eyelid or brow asymmetry....περισσότερα »
Adenoid Cystic Carcinoma of the External Ear
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Adenoid Cystic Carcinoma of the External Ear: A Population Based Study via American Journal of Otolaryngology Publication date: Available online 8 February 2016 *Source:*American Journal of Otolaryngology Author(s): Ross W. Green, Uchechukwu C. Megwalu PurposeTo determine the incidence of adenoid cystic carcinoma of the external ear in the United States, and to evaluate the clinical characteristics and survival outcomes associated with the disease.Materials and MethodsData were extracted from the Surveillance, Epidemiology, and End Results (SEER) 18 Database of the National Cancer Insti... περισσότερα »
Primary squamous cell of the thyroid
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Primary squamous cell of the thyroid–an abbreviated clinical presentation: - Justin T Lui, - Moosa N Khalil and - Shamir P ChandaranaEmail author Journal of Otolaryngology - Head & Neck Surgery201443:17 DOI: 10.1186/1916-0216-43-17 © Lui et al.; licensee BioMed Central Ltd. 2014 Received: 7 December 2013 Accepted: 11 June 2014 Published: 18 June 2014 Abstract Background Lacking any squamous epithelium, thyroid gland with primary squamous cell carcinoma (PSCC) proves to be an etiopathophysiological quandary. Two major theories do exist, though few cases have been docum... περισσότερα »
Head and Neck Paragangliomas: An Update on Evaluation and Management
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Head and Neck Paragangliomas: An Update on Evaluation and Management: Objective Head and neck paragangliomas are a group of slow-growing hypervascular tumors associated with the paraganglion system. The approach to evaluate and treat these lesions has evolved over the last 2 decades. While radical surgery had been the traditional approach, improvements in diagnostic imaging as well as radiation therapy techniques have led to an emphasis on observation and nonsurgical therapy in many patients. This article reviews the contemporary approach to the workup and management of head and nec...περισσότερα »
Is fluorine-18 fluorodeoxyglucose positron emission tomography useful for the thyroid nodules with indeterminate fine needle aspiration biopsy? a meta-analysis of the literature
Ningjian Wang, Hualing Zhai and Yingli LuEmail author Journal of Otolaryngology - Head & Neck Surgery201342:38 DOI: 10.1186/1916-0216-42-38© Wang et al.; licensee BioMed Central Ltd. 2013 Received: 4 February 2013Accepted: 25 May 2013Published: 1 September 2013 Abstract Background The indeterminate fine needle aspiration biopsy (FNAB) results present a clinical dilemma for physicians. The aim of this study was to evaluate the diagnostic accuracy of fluorine-18 fluorodeoxyglucose positron emission tomography (18 F-FDG PET) in the detection of these indeterminate lesions. Methods Seven s... περισσότερα »
Validation of 1-hour post-thyroidectomy parathyroid hormone level in predicting hypocalcemia
ORIGINAL RESEARCH ARTICLE Validation of 1-hour post-thyroidectomy parathyroid hormone level in predicting hypocalcemia Trung N LeEmail author, Paul D Kerr, Donna E Sutherland and Pascal Lambert Journal of Otolaryngology - Head & Neck Surgery201443:5 DOI: 10.1186/1916-0216-43-5© Le et al.; licensee BioMed Central Ltd. 2014 Received: 3 April 2013Accepted: 26 January 2014Published: 29 January 2014 Abstract Background Prior work by our group suggested that a single one hour post-thyroidectomy parathyroid hormone (1 hr PTH) level could accurately stratify patients into high and low risk grou... περισσότερα »
Severe respiratory distress or respiratory compromise
8 questions for critical respiratory compromise patients: By Bob Sullivan Patients in severe respiratory distress or respiratory compromise are often unable to speak more than one or two words at a time, and attempting to do so makes their distress even worse. Use these eight yes-no questions to learn from the patient about their medical history and present illness. These questions are the start of a conversation to guide treatment decisions. With a calm voice, explain to the patient that you need them to nod or shake their head — yes or no — to these questions: *1. Has this h... περισσότερα »
Use of the direct puncture technique in management of capillaro-venous malformations: case report
Use of the direct puncture technique in management of capillaro-venous malformations: case report: Preoperative devascularization of the capillaro-venous malformations located in the aero-digestive tract is important for surgeons, to minimize blood loss during surgical excision of malformations. Vikas Malik, Isha Tyagi, Atul Varma and R V Phadke BMC Ear, Nose and Throat Disorders20022:1 DOI: 10.1186/1472-6815-2-1© Malik et al 2002 Received: 20 September 2001Accepted: 19 March 2002Published: 19 March 2002 Abstract Background Preoperative devascularization of the capillaro-... περισσότερα »
Acute unilateral hearing loss as an unusual presentation of cholesteatoma
Acute unilateral hearing loss as an unusual presentation of cholesteatoma: Cholesteatomas are epithelial cysts that contain desquamated keratin. Patients commonly present with progressive hearing loss and a chronically discharging ear. We report an unusual presentation of the disease...
Direct microvascular monitoring of a free autologous jejunal flap using microendoscopy: a case report
Direct microvascular monitoring of a free autologous jejunal flap using microendoscopy: a case report: Early identification of flap failure is an indispensable prerequisite for flap salvage. Although many technical developments of free flap monitoring have now reached clinical application, very few are consider...
Using Fixed Anatomical Landmarks to Avoid Medial Rectus Injury: A Radiographic Analysis in Patients with and without Graves’ Disease
: A Radiographic Analysis in Patients with and without Graves’ Disease via American Journal of Otolaryngology Publication date: Available online 9 February 2016 *Source:*American Journal of Otolaryngology Author(s): Jeffrey D. Suh, Edward C. Kuan, Christopher F. Thompson, Richard L. Scawn, Aaron J. Feinstein, Henry P. Barham, Todd T. Kingdom, Vijay R. Ramakrishnan BackgroundInjury to the medial rectus (MR) is a potentially devastating complication of orbital and sinus surgery. Precise knowledge of the MR relative to the lamina papyracea (LP) is important during endoscopic surgery for b...περισσότερα »
Chirurgie im Rachen – Adenotomie, Tonsillektomie, Tonsillotomie und Eingriffe bei obstruktivem Schlafapnoe-Syndrom
Chirurgie im Rachen – Adenotomie, Tonsillektomie, Tonsillotomie und Eingriffe bei obstruktivem Schlafapnoe-Syndrom: Laryngo-Rhino-Otol 2016; 95: 132-145 DOI: 10.1055/s-0041-110455 Operative Eingriffe im Rachen gehören zu den häufigsten HNO-Eingriffen. Adenotomie und Tonsillektomie zählen zu den häufigsten operativen Eingriffen überhaupt und sind einige der ersten Eingriffe, die Ärzte während der Facharztausbildung unter fachärztlicher Aufsicht vornehmen. Daher ist eine Beschäftigung mit den häufigsten HNO-Operationen im Rachen, den verschiedenen Techniken, Komplikationen und Erfolg... περισσότερα »
Die Bedeutung der Sonografie bei der Abklärung von Schilddrüsenerkrankungen
Die Bedeutung der Sonografie bei der Abklärung von Schilddrüsenerkrankungen: Laryngo-Rhino-Otol 2016; 95: 87-104 DOI: 10.1055/s-0041-111275 Schilddrüsenknoten und Schilddrüsenveränderungen sind häufige Befunde in der Allgemeinbevölkerung. Die Sonografie ist dabei das wichtigste bildgebende Instrument der Schilddrüsendiagnostik. In Zusammenschau des sonografischen Befunds mit basalen Schilddrüsenhormonparametern und dem klinischen Bild lässt sich in der überwiegenden Zahl der Fälle bereits eine korrekte Diagnose stellen – wie z. B. Hashimoto-Thyreoiditis, eine diffuse Struma oder e... περισσότερα »
SuperSILAC Quantitative Proteome Profiling of Murine Middle Ear Epithelial Cell Remodeling with NTHi
SuperSILAC Quantitative Proteome Profiling of Murine Middle Ear Epithelial Cell Remodeling with NTHi: by Stéphanie Val, Katelyn Burgett, Kristy J. Brown, Diego Preciado Background Chronic Otitis Media with effusion (COME) develops after sustained inflammation and is characterized by secretory middle ear epithelial metaplasia and effusion, most frequently mucoid. Non-typeable *Haemophilus influenzae (NTHi)*, the most common acute Otitis Media (OM) pathogen, is postulated to promote middle ear epithelial remodeling in the progression of OM from acute to chronic. The goals of this s...περισσότερα »
Evaluation of the utricular and saccular function using oVEMPs and cVEMPs in BPPV patients
Evaluation of the utricular and saccular function using oVEMPs and cVEMPs in BPPV patients: Abstract BackgroundIt is well-known that ocular vestibular evoked myogenic potentials (oVEMPs) predominantly reflect utricular function whilst cervical vestibular evoked myogenic potentials (cVEMPs) reflect saccular function. To date, there are no published reports on the systemic evaluation of utricular and saccular function in benign paroxysmal positional vertigo (BPPV), nor are there any reports on the differences in VEMPs between patients with recurrent and non-recurrent BPPV. The aim o...περισσότερα »
Junge Patienten mit Schilddrüsenkarzinom: Zervikale LK-Metastasen beeinflussen Prognose
Junge Patienten mit Schilddrüsenkarzinom: Zervikale LK-Metastasen beeinflussen Prognose: Die Prognose bei jüngeren Patienten mit papillären Schilddrüsenkarzinomen galt bisher als gut, ungeachtet ihres lokoregionären Lymphknotenstatus. Doch man sollte dies differenzierter beurteilen.
Unverträglichkeiten von Otoplastiken sind vermeidbar
Unverträglichkeiten von Otoplastiken sind vermeidbar: Ob in der Hörgeräteversorgung, als Gehörschutz oder als Spritzwasserschutz – Otoplastiken finden vielfach Verwendung. Doch immer wieder klagen Patienten über unangenehme Begleiterscheinungen oder „Unverträglichkeiten“. Derartige, die Trageakzeptanz beeinträchtigende Probleme mit dem Ohrpassstück lassen sich meist vermeiden, wenn einige Kriterien beachtet werden.
Was tun Ärzte bei Atemwegsinfekten?
Was tun Ärzte bei Atemwegsinfekten?: In Deutschland werden zu häufig Antibiotika eingesetzt. Schuld sind angeblich die Ärzte in der Primärversorgung, die diese zu unkritisch verschreiben. Eine Umfrage unter Allgemeinmedizinern zeigt jedoch, dass bei Atemwegsinfekten an erster Stelle Phytotherapeutika verordnet werden. Die Ergebnisse sind auch für HNO-Ärzte relevant.
Was tun Ärzte bei Atemwegsinfekten?
Was tun Ärzte bei Atemwegsinfekten?: In Deutschland werden zu häufig Antibiotika eingesetzt. Schuld sind angeblich die Ärzte in der Primärversorgung, die diese zu unkritisch verschreiben. Eine Umfrage unter Allgemeinmedizinern zeigt jedoch, dass bei Atemwegsinfekten an erster Stelle Phytotherapeutika verordnet werden. Die Ergebnisse sind auch für HNO-Ärzte relevant.
Die Crux mit dem Reflux
Die Crux mit dem Reflux: „Ich hab einen Kloß im Hals.“ „Das Wasser steht mir bis zum Hals.“ „Mir hat es die Stimme verschlagen.“ Bei diesen Beschwerden drängt sich schnell die Diagnose „Globusgefühl“ auf. Da viele psychosomatische Symptome in Sprichwörtern Einzug gehalten haben, bieten derartige Aussagen auch einen guten Ansatzpunkt, um nach möglichen Auslösern zu suchen. Aber steckt hinter jedem „Kloß“ auch ein „Globus hystericus“?
Milbenallergie: Erfolg mit neuen SLIT-Tabletten
Milbenallergie: Erfolg mit neuen SLIT-Tabletten: Täglich eingenommene Tabletten zur sublingualen Immuntherapie (SLIT) lindern bei Milbenallergikern bereits nach 14 Tagen Symptome der allergischen Rhinitis. Das bestätigen die Ergebnisse einer randomisierten placebokontrollierten Doppelblindstudie, in der zwei verschiedene Dosierungen geprüft wurden.
Extraösophageale Ursachen der Dysphagie
Extraösophageale Ursachen der Dysphagie: ZusammenfassungKlagt ein Patient über Schluckbeschwerden ist die Ursache zwar häufig, aber nicht immer im Ösophagus oder dessen nervaler Steuerung zu finden. Auch extraösophageale Störungen sind zu bedenken. Die Kenntnis prägnanter Symptome hilft, den Blick auf diese Ursachen zu lenken, und die fälligen Untersuchungen sind weder belastend noch aufwendig.
Mundhöhlenkrebs: Die Lymphknoten gleich mit entfernen?
Mundhöhlenkrebs: Die Lymphknoten gleich mit entfernen?: Elektive neck dissection oder „watchful waiting“? Welche Strategie bei Plattenepithelkarzinomen in der Mundhöhle im Frühstadium nach einer Exzision des Primärtumors den größeren Vorteil bietet, haben indische Forscher in einer prospektiven und randomisierten Phase-III-Studie untersucht.
Removal of inverted papilloma from the frontal recess: how we do it
Removal of inverted papilloma from the frontal recess: how we do it:
Topical nasal steroids and raised intra-ocular pressure
Establishing a relationship between topical nasal steroids and raised intra-ocular pressure:
Readability and Understandability of Online Vocal Cord Paralysis Materials
Readability and Understandability of Online Vocal Cord Paralysis Materials: Objective Patients use several online resources to learn about vocal cord paralysis (VCP). The objective of this study was to assess the readability and understandability of online VCP patient education materials (PEMs), with readability assessments and the Patient Education Materials Evaluation Tool (PEMAT), respectively. The relationship between readability and understandability was then analyzed. Study Design and Setting Descriptive and correlational design. Method Online PEMs were identified by perfor... περισσότερα »
Phase-Contrast Microscopy,Nasal Ciliary Motility
Effect of Radiofrequency Thermal Ablation Treatment on Nasal Ciliary Motility: A Study with Phase-Contrast Microscopy: Objective To investigate the efficacy of nasal ciliary motility after radiofrequency ablation treatment in patients with isolated inferior turbinate hypertrophy and to clarify how long until normal ciliary function is restored. Study Design Prospective, single-group, pretest-posttest design. Setting Academic tertiary care medical center. Subjects and Methods This study involved 34 adult patients affected by nasal obstruction due to inferior turbinate hypertrophy ... περισσότερα »
Effect of Radiofrequency Thermal Ablation Treatment on Nasal Ciliary Motility
Effect of Radiofrequency Thermal Ablation Treatment on Nasal Ciliary Motility: A Study with Phase-Contrast Microscopy: Objective To investigate the efficacy of nasal ciliary motility after radiofrequency ablation treatment in patients with isolated inferior turbinate hypertrophy and to clarify how long until normal ciliary function is restored. Study Design Prospective, single-group, pretest-posttest design. Setting Academic tertiary care medical center. Subjects and Methods This study involved 34 adult patients affected by nasal obstruction due to inferior turbinate hypertrophy ... περισσότερα »
Organized Hematoma
Organized Hematoma: An Analysis of 84 Cases with Emphasis on Difficult Prediction and Favorable Management: Objective To characterize features of organized hematoma (OH) that may cause considerable diagnostic difficulties. Study Design Case series with chart review. Setting Tertiary medical center. Subjects and Methods Eighty-four patients with pathologically confirmed OH over a 10-year period were retrospectively reviewed for clinical features, imaging findings, pathologic characteristics, and treatment modalities. Results This study included 39 males and 45 females who presen...περισσότερα »
Head and Neck Paragangliomas
Head and Neck Paragangliomas: An Update on Evaluation and Management: Objective Head and neck paragangliomas are a group of slow-growing hypervascular tumors associated with the paraganglion system. The approach to evaluate and treat these lesions has evolved over the last 2 decades. While radical surgery had been the traditional approach, improvements in diagnostic imaging as well as radiation therapy techniques have led to an emphasis on observation and nonsurgical therapy in many patients. This article reviews the contemporary approach to the workup and management of head and nec...περισσότερα »
Definitive Surgical Therapy after Open Neck Biopsy for HPV-Related Oropharyngeal Cancer
Definitive Surgical Therapy after Open Neck Biopsy for HPV-Related Oropharyngeal Cancer: Objective To determine the impact of prior open neck biopsy on the prognosis of patients with human papillomavirus (HPV)–related oropharyngeal squamous cell carcinoma (OPSCC) who are subsequently treated with a definitive surgical paradigm, including adjuvant therapy when indicated. Study Design Retrospective cohort. Setting Tertiary care university hospital. Subjects and Methods Patients with open neck biopsies who were treated with definitive surgery, with or without adjuvant therapy, for ...περισσότερα »
Application of Lean Sigma to the Audiology Clinic at a Large Academic Center
Application of Lean Sigma to the Audiology Clinic at a Large Academic Center: Objective To apply Lean Sigma—a quality improvement strategy to eliminate waste and reduce variation and defects—to improve audiology scheduling and utilization in a large tertiary care referral center. The project goals included an increase in utilization rates of audiology block time and a reduction in appointment lead time. Study Design Prospective quality improvement study. Setting Academic tertiary care center. Subjects All patients scheduling audiology clinic visits July 2013 to July 2014. Metho... περισσότερα »
Novel Anatomic Characteristics of the Laryngeal Framework: A Computed Tomography Evaluation
Novel Anatomic Characteristics of the Laryngeal Framework: A Computed Tomography Evaluation: Objective The thyroid cartilage (TC) in men has a more prominent thyroid notch and a narrower interlaminae angle (ILA) as compared with women. Anatomy textbooks classically stipulate that the ILA is 90° in men and 120° in women. Our observation, based on thyroid chondroplasty operations, of a much narrower angle led to the current investigation. Study Design Cohort imaging study. Setting Tertiary academic referral center. Subjects and Methods Computed tomography angiography neck images o...περισσότερα »
Repair of Posterior Glottic Stenosis with the Modified Endoscopic Postcricoid Advancement Flap
Repair of Posterior Glottic Stenosis with the Modified Endoscopic Postcricoid Advancement Flap: Posterior glottic stenosis is a difficult clinical problem that frequently results in bilateral vocal fold immobility, dyspnea, and tracheostomy dependence. Charts were reviewed of all patients undergoing a modified endoscopic postcricoid advancement flap procedure for posterior glottic stenosis between October 1, 2003, and June 30, 2015. Age, sex, operative findings, complications, and outcomes were noted. Follow-up was available in 10 of 11 patients, 10 of whom were successfully decann... περισσότερα »
Mucoepidermoid Carcinoma at the Mandibular Edentulous Ridge Mucosa: An Infrequent Location
Mucoepidermoid Carcinoma at the Mandibular Edentulous Ridge Mucosa: An Infrequent Location:
HPV-Related Oropharyngeal Cancer
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Definitive Surgical Therapy after Open Neck Biopsy for HPV-Related Oropharyngeal Cancer: Objective To determine the impact of prior open neck biopsy on the prognosis of patients with human papillomavirus (HPV)–related oropharyngeal squamous cell carcinoma (OPSCC) who are subsequently treated with a definitive surgical paradigm, including adjuvant therapy when indicated. Study Design Retrospective cohort. Setting Tertiary care university hospital. Subjects and Methods Patients with open neck biopsies who were treated with definitive surgery, with or without adjuvant therapy, for ...περισσότερα »
Features of Residual Dizziness after Canalith Repositioning Procedures for Benign Paroxysmal Positional Vertigo
Features of Residual Dizziness after Canalith Repositioning Procedures for Benign Paroxysmal Positional Vertigo: Objectives To assess factors related to residual dizziness (RD) in patients who underwent successful canalith repositioning procedures (CRPs) for benign paroxysmal positional vertigo (BPPV). Study Design Prospective cohort study. Setting Academic center. Subjects and Methods Ninety-seven consecutive patients with BPPV of the posterior semicircular canal were initially enrolled. Diagnosis was assessed according to clinical history and bedside evaluation. All patients w...περισσότερα »
Assessment of sediment quality based on acid-volatile sulfide and simultaneously extracted metals in heavily industrialized area of Asaluyeh, Persian Gulf: concentrations, spatial distributions, and sediment bioavailability/toxicity
Abstract Sediment samples from the coastal area of Asaluyeh harbor were collected during autumn and spring 2015. The acid-volatile sulfide (AVS) and simultaneously extracted metals (SEMs) were measured to assess the sediment quality and potential ecological risks. The average concentrations (and relative standard deviation (RSD)) of AVS in the industrial sediments were 12.32 μmol/g (36.91) and 6.34 μmol/g (80.05) in autumn and spring, respectively, while in the urban area, these values were 0.44 μmol/g (123.50) and 0.31 μmol/g (160.0) in autumn and spring, respectively. The averag...περισσότερα »
Simultaneous nitrification and denitrification in a novel membrane bioelectrochemical reactor with low membrane fouling tendency
Abstract Microbial fuel cells (MFCs) can use nitrate as a cathodic electron acceptor for electrochemical denitrification, yet there is little knowledge about how to apply them into current wastewater treatment process to achieve efficient nitrogen removal. In this study, two dual-chamber MFCs were integrated with an aerobic membrane bioreactor to construct a novel membrane bioelectrochemical reactor (MBER) for simultaneous nitrification and denitrification under specific aeration. The effects of chemical oxygen demand (COD) loading rate, COD/N ratio, hydraulic retention time (HRT),... περισσότερα »
Multivariate co-integration analysis of the Kaya factors in Ghana
Abstract The fundamental goal of the Government of Ghana's development agenda as enshrined in the Growth and Poverty Reduction Strategy to grow the economy to a middle income status of US$1000 per capita by the end of 2015 could be met by increasing the labour force, increasing energy supplies and expanding the energy infrastructure in order to achieve the sustainable development targets. In this study, a multivariate co-integration analysis of the Kaya factors namely carbon dioxide, total primary energy consumption, population and GDP was investigated in Ghana using vector error ...περισσότερα »
Land spreading of sewage sludge in forest plantations: effects on the growth of the duckweed Lemna minor and trace metal bioaccumulation in the snail Cantareus aspersus
Abstract Wastewater plants generated annually millions of tons of sewage sludge (SS). Large amounts of this organic residue are spread on agricultural lands as a fertilizer, although it is viewed as a major potential source of contamination, presenting a danger to the terrestrial and aquatic environments. This study was undertaken to evaluate the impact of this practice on the duckweed *Lemna minor* and the snail *Cantareus aspersus*. Sludge was applied to soil either at six different loading rates equal to 0, 0.4, 3, 10, 30, and 60 tons dry matter (DM) ha−1 for *L. minor* test or ... περισσότερα »
Effects of calcium supplementation on growth and biochemistry in two passerine species breeding in a Ca-poor and metal-polluted area
Abstract Several studies provide evidence of calcium (Ca)-limited reproduction in birds. A Ca-supplementation experiment was carried out in 2014 in a Ca-poor area associated with metal pollution in SW Finland. We aimed to evaluate the relationship between Ca availability and heavy metal exposure in free-living passerines, and to compare Ca levels in plasma and feces and the effects of Ca supplementation and metals on breeding, nestling growth, and plasma biochemistry in great tits and pied flycatchers. Although the Ca supplement was used by parents, in general the treatment had lim... περισσότερα »
Variations in the accumulation and translocation of cadmium among pak choi cultivars as related to root morphology
Abstract A pot experiment was performed to investigate the variations in cadmium (Cd) accumulation among pak choi cultivars and its relationships to root morphology. The biomass, Cd accumulation and root morphology of 20 pak choi cultivars were determined in low and high Cd treatments. Significant variations in Cd accumulation and root morphological parameters were observed between pak choi cultivars. Cd concentrations in shoots differed between cultivars by a factor of 2.3 (13.3–30.8 μg g–1) and 2.6 (35.5–94.0 μg g–1) for low and high Cd treatments, respectively. The total Cd in ...περισσότερα »
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Erratum to: Bone healing after low-level laser application in extraction sockets grafted with allograft material and covered with a resorbable collagen dressing: a pilot histological evaluation
from #Dental via xlomafota13 on Inoreader http://ift.tt/1o1M6y7 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Naringenin targets ERK2 and suppresses UVB-induced photoaging
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract A number of natural phytochemicals have anti-photoaging properties that appear to be mediated through the inhibition of matrix metalloproteinase-1 (MMP-1) expression, but their direct target molecule(s) and mechanism(s) remain unclear. We investigated the effect of naringenin, a major flavonoid found in citrus, on UVB-induced MMP-1 expression and identified its direct target. The HaCaT human skin keratinocyte cell line and 3-dimensional (3-D) human skin equivalent cultures were treated or not treated with naringenin for 1 hr before exposure to UVB. The mechanism and target...περισσότερα »
The genetic classification of prostate cancer: what’s on the horizon?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/1Wd25E1 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SfdRzt via IFTTT
Methods of a large prospective, randomised, open-label, blinded end-point study comparing morning versus evening dosing in hypertensive patients: the Treatment In Morning versus Evening (TIME) study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Introduction Nocturnal blood pressure (BP) appears to be a better predictor of cardiovascular outcome than daytime BP. The BP lowering effects of most antihypertensive therapies are often greater in the first 12 h compared to the next 12 h. The Treatment In Morning versus Evening (TIME) study aims to establish whether evening dosing is more […]
Matrix metalloproteinase-11 as a marker of metastasis and predictor of poor survival in urothelial carcinomas
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Background and Objectives Urothelial carcinomas (UC) of urinary bladder (UB) and upper urinary tract (UT) are heterogeneous diseases with high morbidity and mortality. We looked for genes with metalloendopeptidase activity in a published UBUC transcriptomic database (GSE31684):MMP-11 was the most significant, showing stepwise up-regulation. We analyzed MMP-11 expression and association with clinicopathologic factors and survival […]
Adiposity and response to an obesity prevention intervention in Pakistani and Bangladeshi primary school boys and girls: a secondary analysis using the BEACHeS feasibility study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Objectives As a secondary analysis of the BEACHeS study, we hypothesised there would be sex differences in Pakistani and Bangladeshi school children when examining adiposity and their response to an obesity intervention. Design The Birmingham healthy Eating and Active lifestyle for CHildren Study (BEACHeS) was designed as a Phase II feasibility study of a complex […]
Significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and prognostic nutrition index as preope rative predictors of early mortality after liver resection for huge (≥10 cm) hepatocellular carcinoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Background This study aimed to determine preoperative predictors of early (<1 year) mortality from disease recurrence after liver resection (LR) for huge (≥10 cm) HCC, with special emphasis on the importance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and prognostic nutrition index (PNI). Methods Between 2000 to 2013, 166 patients underwent LR for huge HCC. Optimal […]
Exploring provision of Innovative Community Education Placements (ICEPs) for junior doctors in training: a qualitative study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Objective Medical education in community settings is an essential ingredient of doctors’ training and a key factor in recruiting general practitioners (GP). Health Education England’s report ‘Broadening the Foundation’ recommends foundation doctors complete 4-month community placements. While Foundation GP schemes exist; other community settings, are not yet used for postgraduate training. The objective of this […]
MicroRNA-194 is a Marker for Good Prognosis in Clear Cell Renal Cell Carcinoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Abstract Clear cell renal cell carcinoma (ccRCC) is the most prevalent adult kidney cancer. Prognostic markers are needed to guide patient management toward aggressive versus more conservative approaches, especially for small tumors ≤4 cm. miR-194 was reported to be downregulated in several cancers and is involved in epithelial to mesenchymal transition. We evaluated miR-194 as […]
Immigrant mothers and access to prenatal care: evidence from a regional population study in Italy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Objectives We addressed the question of whether use of adequate prenatal care differs between foreign-born and Italian mothers and estimated the extent to which unobservable characteristics bias results. Setting This study is on primary care and especially on adequate access to prenatal healthcare services by immigrant mothers. Participants Approximately 37 000 mothers of both Italian […]
Translational and clinical research highlights from the 38th San Antonio Breast Cancer Symposium
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/20KaKEE via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SfdPYr via IFTTT
Utilisation of helicopter emergency medical services in the early medical response to major incidents: a systematic literature review
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Objective This systematic review identifies, describes and appraises the literature describing the utilisation of helicopter emergency medical services (HEMS) in the early medical response to major incidents. Setting Early prehospital phase of a major incident. Design Systematic literature review performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. MEDLINE, EMBASE, the […]
Erratum: Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics
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Elevated VEGFA mRNA levels in oral squamous cell carcinomas and tumor margins: a preliminary study
Background New blood vessel formation events are essential for tumor clonal expansion and progression. Despite the importance of vascular endothelial growth factor A (VEGFA) for tumor angiogenesis, few studies have evaluated the expression profile of this gene in oral squamous cell carcinoma (OSCC) and tumor margins (TM). This study aimed to evaluate the expression of the VEGFA gene and its protein in OSCC and TM. Methods Gene expression was evaluated in cryopreserved samples of OSCCs (*n* = 44), TM (*n* = 7), and normal mucosa from healthy patients (*n* = 3; NM). Quantitative P... περισσότερα »
Global Smart Motors Market 2016 Expected growth by QY Market Research
Global Smart Motors Industry 2015 Market Research Report is a professional and in-depth study on the current state of the Smart Motors industry. The report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure.The Smart Mot... from Infection via ola Kala on Inoreader http://ift.tt/1V2H52C via IFTTT
Global Smart card Market 2016 is expected treach $10.32 billion by 2022 According to Market Research Store
Global Smart card Market is estimated tbe $6,191.4 million in 2014 and is expected treach $10.32 billion by 2022 growing at a CAGR of 6.6% from 2014 t2022. Some of the key drivers for the market growth include escalating demand for safe and consistent transactions, growing number of mobile users... from Infection via ola Kala on Inoreader http://ift.tt/23W5M6M via IFTTT
Reduced Ets domain-containing protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin {alpha}v{beta}6 Expression Gene Regulation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with high mortality. Active Transforming Growth Factor-β1 (TGF-β1) is considered central to the pathogenesis of IPF. A major mechanisms of TGF-β1 activation in the lung involves the epithelially restricted αvβ6 integrin. Expression of the αvβ6 integrin is dramatically increased in IPF. How αvβ6 integrin expression […]
Identification of Unintuitive Features of Sumoylation Through Mathematical Modeling Computational Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Sumoylation is a multi-step multi-enzymatic post-translational modification in which a small ubiquitin like modifier protein (SUMO) is attached to the target. We present the first mathematical model for sumoylation including enzyme mechanism details such as auto-sumoylation of E2 and multifunctional nature of SENP. Simulations and analysis reveal three non-obvious properties for the long-term response, modeled […]
Pro-recombination role of Srs2 requires SUMO but is independent of PCNA interaction DNA and Chromosomes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Srs2 plays many roles in DNA repair, the proper regulation and coordination of which is essential. Post-translational modification by Small Ubiquitin-like Modifier (SUMO) is one such possible mechanism. Here, we investigate SUMO’s role in Srs2 regulation and show that the SUMO-interacting motif (SIM) of Srs2 is important for the interaction with several recombination factors. Lack […]
High resolution structures of periplasmic glucose binding protein of Pseudomonas putida CSV86 reveal structural basis of its substrate specificity Protein Structure and Folding
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Periplasmic substrate binding proteins (SBPs) bind to the specific ligand with high affinity and mediate their transport into the cytoplasm via the cognate inner membrane ATP binding cassette (ABC) proteins. Because of very low sequence identities, understanding the structural basis of substrate recognition by SBPs has remained very challenging. There are several structures available for […]
Co-immunoprecipitation with tau isoform-specific antibodies reveals distinct protein interactions, and highlights a putative role for 2N tau in disease Neurobiology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Alternative splicing generates multiple isoforms of the microtubule-associated protein tau, but little is known about their specific function. In the adult mouse brain, three tau isoforms are expressed that contain either 0, 1 or 2 amino-terminal inserts (0N, 1N, 2N). We generated tau isoform-specific antibodies and performed co-immunoprecipitations followed by tandem mass tag multiplexed quantitative […]
Health-related quality of life and prospective caries development
Abstract Background The present study was conducted to prospectively assess the association between health-related quality of life (HRQoL) and the development of dental caries in adults in northern Sweden. The SF-36 questionnaire was used to estimate HRQoL. Methods Adults who had (i) participated in a population-based health screening in northern Sweden between 2003 and 2009 and had completed the SF-36 questionnaire, and (ii) received a dental check-up within 1 year (*n* = 15,615) were included in the study. Of these, 9,838 had a second caries examination 2–7 years after the base...περισσότερα »
Subchronic toxicology of tetrabromobisphenol A in rats
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Tetrabromobisphenol A (TBBPA) is used to protect a wide range of electrical and electronic equipment, consumer electronics and office and communication equipment from catching fire. TBBPA reacts covalently with other monomers becoming an integral part of the cross-linked molecular structure. This study was conducted to evaluate the subchronic toxicity of TBBPA administered by gavage daily […]
Recruitment strategies at the Iowa site for parent/infant pairs in a longitudinal dental caries study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Background/aims: Recruitment of parent/infant pairs can be more difficult and challenging than recruitment of adult subjects alone as the parent has to consider themselves along with the infant to be study participants. In order to determine which recruitment methods most effectively resulted in accrual of subjects, recruitment efforts at the University of Iowa were evaluated, […]
Meralgia paraesthetica: Ultrasound-guided injection at multiple levels with 12-month follow-up
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Objectives To evaluate the efficacy of ultrasound (US)-guided injections around the lateral femoral cutaneous nerve (LFCN) at different levels in meralgia paraesthetica (MP) patients. Methods The study was approved by the university ethics committee and informed oral and written consent were obtained from all patients. Between June 2008 and August 2013, 20 patients with […]
Intentional poisoning among elderly people–residents of a large urban agglomeration in Poland
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Poisoning is considered a significant health problem among elderly people in Poland. This report refers to patients treated for poisonings at the Toxicology Unit, Lodz, Poland, during the period 2008–2012. The data to be analyzed were obtained from medical records of elderly people. A group of 1167 patients aged 60+ was selected. The number of […]
Perinatal air pollution exposure and development of asthma from birth to age 10 years
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Within-city variation in air pollution has been associated with childhood asthma development, but findings have been inconsistent. We examined whether perinatal air pollution exposure affected asthma onset during «pre-school and «school age» periods in a population-based birth cohort. 65 254 children born between 1999 and 2002 in the greater Vancouver metropolitan region were followed until […]
Pyrrolidine dithiocarbamate attenuates paraquat-induced acute pulmonary poisoning in vivo via transforming growth factor {beta}1 and nuclear factor {kappa}B pathway interaction
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Paraquat (PQ) exposure could cause pulmonary fibrosis. The aim of this study was to investigate the protective effect of pyrrolidine dithiocarbamate (PDTC) in an acute PQ poison model. One hundred and forty-four Sprague Dawley rats were equally divided into three experimental groups: control group, PQ group, and PQ + PDTC group. At days 1, 3, […]
Effect of bixin on DNA damage and cell death induced by doxorubicin in HL60 cell line
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Bixin is a natural red pigment extracted from annatto. Although it is widely used as a coloring agent in food, there are few studies about the effect of this carotenoid on DNA. This study aimed to investigate the effects of bixin on cytotoxicity and genotoxicity induced by doxorubicin in HL60 cells. At concentrations above 0.3 […]
Abdominal fat volume estimation by stereology on CT: a comparison with manual planimetry
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Objectives To deploy and evaluate a stereological point-counting technique on abdominal CT for the estimation of visceral (VAF) and subcutaneous abdominal fat (SAF) volumes. Methods Stereological volume estimations based on point counting and systematic sampling were performed on images from 14 consecutive patients who had undergone abdominal CT. For the optimization of the method, […]
MR elastography of the liver at 3.0 T in diagnosing liver fibrosis grades; preliminary clinical experience
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Objectives To clarify the usefulness of 3.0-T MR elastography (MRE) in diagnosing the histological grades of liver fibrosis using preliminary clinical data. Materials and methods Between November 2012 and March 2014, MRE was applied to all patients who underwent liver MR study at a 3.0-T clinical unit. Among them, those who had pathological evaluation […]
Jugular paragangliomas—Resection techniques
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The prerequisites for surgical resection of tumors arising in the jugular foramen are adequate access, control of the major vessels, and the ability to move the facial nerve safely of the operative field if necessary. Without it the surgeon risks catastrophic hemorrhage, cranial nerve palsies that might have been avoided, and insufficient access to remove […]
Clinical significance of three-dimensional measurement of tumour thickness on magnetic resonance imaging in patients with oral tongue squamous cell carcinoma
Abstract Objectives To identify the clinical significance of primary tumour thickness (TT) and its direction in patients with oral tongue squamous cell carcinoma (OTSCC), we measured TT in all axial/coronal/sagittal views on magnetic resonance imaging (MRI) and evaluated their meaning. Methods A total of 53 OTSCC patients were analysed who had undergone preoperative three-dimensional MRI and had been surgically treated. TT measured on axial (mediolateral direction), coronal (superoinferior direction), and sagittal (anteroposterior direction) views was compared to that in pathologi... περισσότερα »
Reply to Letter to the Editor re: Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: Correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol
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Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT
Abstract Objectives To date, PROPELLER MRI, a breathing-motion-insensitive technique, has not been assessed for cystic fibrosis (CF) lung disease. We compared this technique to CT for assessing CF lung disease in children and adults. Methods Thirty-eight stable CF patients (median 21 years, range 6-51 years, 22 female) underwent MRI and CT on the same day. Study protocol included respiratory-triggered PROPELLER MRI and volumetric CT end-inspiratory and -expiratory acquisitions. Two observers scored the images using the CF-MRI and CF-CT systems. Scores were compared with intra-clas... περισσότερα »
Dedicated sub 0.1 mSv 3DCT using MBIR in children with suspected craniosynostosis: quality assessment
Abstract Objective To retrospectively compare image quality of a lowered dose CT protocol to a standard CT protocol in children with suspicion of craniosynostosis. Methods Forty-eight patients (age 0- 35 months), who presented with a cranial deformity underwent cranial 3D CT to assess sutural patency: between 2009 – 2010, 24 patients were imaged with a standard protocol (CTDIvol 32.18 mGy), from 2011-2012, 24 underwent a low dose protocol (0.94 mGy) combined with iterative reconstruction. Image quality was evaluated by both expert reading and objective analysis. Differences were a...περισσότερα »
Imaging of mesothelioma of tunica vaginalis testis
Abstract Objectives To describe the imaging findings in a series of patients with mesothelioma of the tunica vaginalis testis. Methods We reviewed clinical data, imaging findings and follow-up information in a series of 10 pathology-proven cases of mesothelioma (all had US; 2 had MR) of the tunica vaginalis. Results A variety of patterns could be observed, the most common (5/10) being a hydrocele with parietal, solid and hypervascular vegetations; one patient had a septated hydrocele with hypervascular walls; one had multiple, solid nodules surrounded by a small, physiological q... περισσότερα »
Pancreatic adenocarcinomas without secondary signs on multiphasic multidetector CT: association with clinical and histopathologic features
Abstract Purpose To determine the clinical, histopathologic and imaging features of pancreatic adenocarcinomas without secondary signs on dynamic CT. Materials and Methods Seventy patients (mean age 70 years) with histologically proven pancreatic adenocarcinoma underwent preoperative contrast material-enhanced multiphasic multidetector CT before pancreatic resection. In each patient, clinical data including carbohydrate antigen 19–9, frequency of isoattenuating tumours, and presence of secondary signs and histopathologic findings such as tumour location, tumour stage, and microsco... περισσότερα »
Combined reading of Contrast Enhanced and Diffusion Weighted Magnetic Resonance Imaging by using a simple sum score
Abstract Objective To improve specificity of breast MRI by integrating Apparent Diffusion Coefficient (ADC) values with contrast enhanced MRI (CE-MRI) using a simple sum score. Methods Retrospective analysis of a consecutive series of patients referred to breast MRI at 1.5 T for further workup of breast lesions. Reading results of CE-MRI were dichotomized into score 1 (suspicious) or 0 (benign). Lesion's ADC-values (in *10-3 mm2/s) were assigned two different scores: ADC 2: likely malignant (score +1, ADC ≤ 1), indeterminate (score 0, ADC >1- ≤ 1.4) and likely benign (score -1, AD...περισσότερα »
Meralgia paraesthetica: Ultrasound-guided injection at multiple levels with 12-month follow-up
Abstract Objectives To evaluate the efficacy of ultrasound (US)-guided injections around the lateral femoral cutaneous nerve (LFCN) at different levels in meralgia paraesthetica (MP) patients. Methods The study was approved by the university ethics committee and informed oral and written consent were obtained from all patients. Between June 2008 and August 2013, 20 patients with symptoms of MP, including nine men (mean age, 61.33 years) and 11 women (mean age 61.18 years), were treated with US-guided injection of steroids along the LFCN at three different levels in a mean of 2.25... περισσότερα »
Abdominal fat volume estimation by stereology on CT: a comparison with manual planimetry
Abstract Objectives To deploy and evaluate a stereological point-counting technique on abdominal CT for the estimation of visceral (VAF) and subcutaneous abdominal fat (SAF) volumes. Methods Stereological volume estimations based on point counting and systematic sampling were performed on images from 14 consecutive patients who had undergone abdominal CT. For the optimization of the method, five sampling intensities in combination with 100 and 200 points were tested. The optimum stereological measurements were compared with VAF and SAF volumes derived by the standard technique of...περισσότερα »
MR elastography of the liver at 3.0 T in diagnosing liver fibrosis grades; preliminary clinical experience
Abstract Objectives To clarify the usefulness of 3.0-T MR elastography (MRE) in diagnosing the histological grades of liver fibrosis using preliminary clinical data. Materials and methods Between November 2012 and March 2014, MRE was applied to all patients who underwent liver MR study at a 3.0-T clinical unit. Among them, those who had pathological evaluation of liver tissue within 3 months from MR examinations were retrospectively recruited, and the liver stiffness measured by MRE was correlated with histological results. Institutional review board approved this study, waiving i... περισσότερα »
Changes in cognitive function and brain glucose metabolism in elderly women with subjective memory impairment: a 24-month prospective pilot study
Objectives Subjective memory impairment (SMI) may precede mild cognitive impairment (MCI) stage and would offer an earlier therapeutic opportunity than MCI would. However, it is not clear whether complaints of forgetfulness are truly reflective of objective memory dysfunction or of impairments in other cognitive domains. The aim of this current longitudinal study was to investigate changes in various cognitive functions and in regional cerebral metabolic rate of glucose (rCMRglc) among elderly women with SMI. Materials and methods Clinical evaluation, comprehensive neuropsycholog... περισσότερα »
High-resolution manometric subtypes as a predictive factor for the treatment of achalasia: a meta-analysis and systematic review
Abstract Aim This study assessed manometric subtypes as predictive factors for the treatment efficacies of pneumatic balloon dilatation (PD) and laparoscopic Heller myotomy (LHM) in patients with achalasia. Methods A systematic search of the Cochrane Library Central database, PubMed and Embase was conducted to identify relevant publications on high-resolution manometric subtypes and different therapies for achalasia with predefined inclusion and exclusion criteria. Data on the success rates after PD or LHM for different manometric subtypes were extracted. The pooled odds ratios ...περισσότερα »
A non-invasive magnetic resonance imaging-based model predicts portal venous pressure
AIM To establish a non-invasive model for the assessment of portal venous pressure (PVP) based on the magnetic resonance imaging (MRI) parameters. METHODS In this prospective, Ethics Committee-approved study, contrast-enhanced MRI scanning was performed on 109 patients indicated for upper abdominal surgeries after written consents obtained, and intraoperative PVP measurement was completed in 92 patients. Seventeen patients were excluded for not undergoing surgery or unsuccessful catheterization. A linear model was constructed for the estimation of PVP values on 56 patients. A va... περισσότερα »
Delayed perforation after endoscopic band ligation for the treatment of colonic diverticular bleeding
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Surveillance colonoscopy after endoscopic treatment for colorectal neoplasia: From the standpoint of the Asia-Pacific region
Colonoscopy is considered the gold standard to detect and remove colorectal neoplasia. The efficacy of colonoscopy with polypectomy to reduce colorectal cancer incidence and mortality has been demonstrated. Recently, post-polypectomy surveillance colonoscopy has become a necessary intervention in daily practice not only in the Western countries but also in the Asia-Pacific region. Therefore, it is crucial to establish new clinical practice guidelines to reduce the number of unnecessary surveillance colonoscopies in order to create space for screening colonoscopy. The Asia-Pacific...περισσότερα »
Abstract withdrawn
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Abstract withdrawn
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Abstract withdrawn
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Re: ‘Hemothorax Management After Endovascular Treatment for Thoracic Aortic Rupture’
Publication date: Available online 9 February 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): O. Gokalp, B. Eygi, Y. Besir, L. Yilik, M. Balkanay, G. Gokalp, A. Gurbuz from Endocrinology via ola Kala on Inoreader http://ift.tt/1oqA1SS via IFTTT
Mesial temporal lobe epilepsy with childhood febrile seizure
Objectives To evaluate the demographic and clinical manifestations of patients with mesial temporal sclerosis and temporal lobe epilepsy (MTS-TLE) with childhood febrile seizure (FS) and establishing the potential differences as compared to those without FS. We also investigated the surgery outcome in these two groups of patients. Materials and methods In this retrospective study, all patients with a clinical diagnosis of drug-resistant TLE due to mesial temporal sclerosis, who underwent epilepsy surgery at Jefferson Comprehensive Epilepsy Center, were recruited. Patients were p... περισσότερα »
Squamous Dysplasia of the Urinary Bladder: A Consecutive Cystectomy Series
Squamous dysplasia of the urinary bladder is uncommon and may represent a precursor to invasive squamous cell carcinoma. Though significant focus has been devoted to squamous differentiation in invasive bladder cancer, relatively little attention has been given to squamous dysplasia. We methodically reviewed microscopic slides from a consecutive cystectomy series at our institution (n = 303; 2001-2014), with special attention given to squamous dysplasia and squamous differentiation within association invasive carcinoma. Of these 303 cases, 3% (9 cases) had squamous dysplasia. The ... περισσότερα »
Applicability of HCV RNA viral load thresholds for 8-week treatments in patients with chronic hepatitis C genotype 1 infection
Determination of baseline HCV RNA thresholds for 8-week treatment regimens as suggested by phase 3 trial data may not be reliably applied in clinical practice as the level of HCV RNA is highly variable and greatly depends on the assay used. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1KEpwFx via IFTTT
Proprioceptive ability at the lips and jaw measured using the same psychophysical discrimination task
Abstract In the human face, the muscles and joints that generate movement have different properties. Whereas the jaw is a conventional condyle joint, the facial musculature has neither distinct origin nor insertion points, and the muscles do not contain muscle spindle proprioceptors. This current study aims to compare the proprioceptive ability at the orofacial muscles with that of the temporomandibular joint (TMJ) in 21 neuro-typical people aged between 18 and 65 years. A novel psychophysical task was devised for use with both structures that involved a fixed 30.5 mm start separat... περισσότερα »
Squamous Dysplasia of the Urinary Bladder: A Consecutive Cystectomy Series
Squamous dysplasia of the urinary bladder is uncommon and may represent a precursor to invasive squamous cell carcinoma. Though significant focus has been devoted to squamous differentiation in invasive bladder cancer, relatively little attention has been given to squamous dysplasia. We methodically reviewed microscopic slides from a consecutive cystectomy series at our institution (n = 303; 2001-2014), with special attention given to squamous dysplasia and squamous differentiation within association invasive carcinoma. Of these 303 cases, 3% (9 cases) had squamous dysplasia. The ... περισσότερα »
The Attitudes of Medical Students toward the Importance of Understanding Classical Greek and Latin in the Development of an Anatomical and Medical Vocabulary
Abstract Students on entering medical school are faced with acquiring new, and voluminous, anatomical and medical terminologies. A reason why acquiring these terminologies may be problematic relates to the fact that many terms are derived from classical Greek and Latin; languages nowadays that are rarely taught at school. It might also be supposed that the often reported reduction in exposure to anatomy, and time spent in the dissection room, impairs the students' knowledge and understanding of anatomical relationships, and thus further complicates the acquisition of the terminolo...περισσότερα »
β-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Liver metastasis development in breast cancer patients is common and confers a poor prognosis. So far, the prognostic significance of surgical resection and clinical relevance of biomarker analysis in metastatic tissue have barely been investigated. We previously demonstrated an impact of WNT signaling in breast cancer brain metastasis. This study aimed to investigate the […]
Identification of a novel epitope derived from the cancer-germline antigen, HAGE, displaying both in-vitro and in-vivo immunogenicity
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/20nmcR3 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Large scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
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High frequency of functionally active Melan-A specific T cells in a patient with progressive immunoproteasome-deficient melanoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/20nmcAD via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
PBMCs transfected with RNActive stimulate specific T-cells
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/20nmcAs via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Therapeutic efficacy of RAGE-1 and MAGE-9 peptide specific cytotoxic T cell clones in renal cell carcinoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/20JQp22 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Photographic Objective Alterations for Laryngopharyngeal Reflux Diagnosis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Diagnosis of laryngopharyngeal reflux (LPR) in clinical practice is generally made subjectively based on history, symptoms, and endoscopic assessment. This study presents the diagnostic role of the digital photographic assessment of the laryngopharyngeal region for LPR. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PjPoW5 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & […]
Auditory-perceptual Evaluation of Normal and Dysphonic Voices Using the Voice Deviation Scale
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
This study aims to (1) determine the cutoff values of the overall severity (OS) of vocal deviation on the visual analog scale (VAS) based on the ratings of the numerical scale (NS); and (2) verify the power of discrimination of these cutoff values according to different degrees of vocal deviation. from #ORL-AlexandrosSfakianakis via simeraentaxei on […]
The Effect of Hydration on the Voice Quality of Future Professional Vocal Performers
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
The application of systemic hydration as an instrument for optimal voice quality has been a common practice by several professional voice users over the years. Although the physiological action has been determined, the benefits on acoustic and perceptual characteristics are relatively unknown. The present study aimed to determine whether systemic hydration has beneficial outcomes on […]
Vocal Responses in Heighted States of Arousal
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
The purpose of this study was to investigate electroglottography (EGG) contact quotient modulation with emotional state in the presence of increased arousal. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/20JOuur via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Pancreatic adenocarcinomas without secondary signs on multiphasic multidetector CT: association with clinical and histopathologic features
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Purpose To determine the clinical, histopathologic and imaging features of pancreatic adenocarcinomas without secondary signs on dynamic CT. Materials and Methods Seventy patients (mean age 70 years) with histologically proven pancreatic adenocarcinoma underwent preoperative contrast material-enhanced multiphasic multidetector CT before pancreatic resection. In each patient, clinical data including carbohydrate antigen 19–9, frequency of isoattenuating […]
Increases in Sex Hormones during Anti-Tumor Necrosis Factor α Therapy in Adolescents with Crohn’s Disease
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Publication date: Available online 9 February 2016 Source:The Journal of Pediatrics Author(s): Mark D. DeBoer, Meena Thayu, Lindsay M. Griffin, Robert N. Baldassano, Lee A. Denson, Babette S. Zemel, Michelle R. Denburg, Hannah E. Agard, Rita Herskovitz, Jin Long, Mary B. Leonard ObjectiveTo evaluate children with Crohn’s disease for inverse relationships between systemic inflammatory cytokines […]
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fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Publication date: Available online 9 February 2016 Source:The Journal of Pediatrics Author(s): Wayne J. Morgan, David J. Pasta, Michael W. Konstan from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QUAeaf via IFTTT
Combined reading of Contrast Enhanced and Diffusion Weighted Magnetic Resonance Imaging by using a simple sum score
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Objective To improve specificity of breast MRI by integrating Apparent Diffusion Coefficient (ADC) values with contrast enhanced MRI (CE-MRI) using a simple sum score. Methods Retrospective analysis of a consecutive series of patients referred to breast MRI at 1.5 T for further workup of breast lesions. Reading results of CE-MRI were dichotomized into score […]
Meralgia paraesthetica: Ultrasound-guided injection at multiple levels with 12-month follow-up
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Objectives To evaluate the efficacy of ultrasound (US)-guided injections around the lateral femoral cutaneous nerve (LFCN) at different levels in meralgia paraesthetica (MP) patients. Methods The study was approved by the university ethics committee and informed oral and written consent were obtained from all patients. Between June 2008 and August 2013, 20 patients with […]
Recruitment strategies at the Iowa site for parent/infant pairs in a longitudinal dental caries study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Background/aims: Recruitment of parent/infant pairs can be more difficult and challenging than recruitment of adult subjects alone as the parent has to consider themselves along with the infant to be study participants. In order to determine which recruitment methods most effectively resulted in accrual of subjects, recruitment efforts at the University of Iowa were evaluated, […]
Perinatal air pollution exposure and development of asthma from birth to age 10 years
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Within-city variation in air pollution has been associated with childhood asthma development, but findings have been inconsistent. We examined whether perinatal air pollution exposure affected asthma onset during «pre-school and «school age» periods in a population-based birth cohort. 65 254 children born between 1999 and 2002 in the greater Vancouver metropolitan region were followed until […]
Abdominal fat volume estimation by stereology on CT: a comparison with manual planimetry
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Objectives To deploy and evaluate a stereological point-counting technique on abdominal CT for the estimation of visceral (VAF) and subcutaneous abdominal fat (SAF) volumes. Methods Stereological volume estimations based on point counting and systematic sampling were performed on images from 14 consecutive patients who had undergone abdominal CT. For the optimization of the method, […]
MR elastography of the liver at 3.0 T in diagnosing liver fibrosis grades; preliminary clinical experience
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Objectives To clarify the usefulness of 3.0-T MR elastography (MRE) in diagnosing the histological grades of liver fibrosis using preliminary clinical data. Materials and methods Between November 2012 and March 2014, MRE was applied to all patients who underwent liver MR study at a 3.0-T clinical unit. Among them, those who had pathological evaluation […]
Jugular paragangliomas—Resection techniques
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
The prerequisites for surgical resection of tumors arising in the jugular foramen are adequate access, control of the major vessels, and the ability to move the facial nerve safely of the operative field if necessary. Without it the surgeon risks catastrophic hemorrhage, cranial nerve palsies that might have been avoided, and insufficient access to remove […]
Blood glucose fluctuation accelerates renal injury involved to inhibit the AKT signaling pathway in diabetic rats
Abstract Blood glucose fluctuation is associated with diabetic nephropathy. However, the mechanism by which blood glucose fluctuation accelerates renal injury is not fully understood. The aim of the present study was to assess the effects of blood glucose fluctuation on diabetic nephropathy in rats and investigate its underlying mechanism. Diabetes in the rats was induced by a high sugar, high-fat diet, and a single dose of STZ (35 mg/kg)-injected intraperitoneally. Unstable blood sugar models were induced by subcutaneous insulin injection and intravenous glucose injection alternat... περισσότερα »
Association of primary aldosteronism with chronic thyroiditis
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The role of nitrogen and phosphorus in regulating Phormidium sp. (Cyanobacteria) growth and anatoxin production
Benthic proliferations of the cyanobacteria *Phormidium* can cover many kilometres of riverbed. *Phormidium* can produce neurotoxic anatoxins and ingestion of benthic mats has resulted in numerous animal poisonings in the last decade. Despite this, there is a poor understanding of the environmental factors regulating growth and anatoxin production. In this study the effects of nitrogen and phosphorus on the growth of two *Phormidium* strains (anatoxin-producing and non-anatoxin-producing) were examined in batch monocultures. Cell concentrations were significantly reduced under red... περισσότερα »
Amoeba-resisting bacteria found in multilamellar bodies secreted by Dictyostelium discoideum: social amoebae can also package bacteria
Many bacteria can resist phagocytic digestion by various protozoa. Some of these bacteria (all human pathogens) are known to be packaged in multilamellar bodies produced in the phagocytic pathway of the protozoa and that are secreted into the extracellular milieu. Packaged bacteria are protected from harsh conditions, and the packaging process is suspected to promote bacterial persistence in the environment. To date, only a limited number of protozoa, belonging to free-living amoebae and ciliates, have been shown to perform bacteria packaging. It is still unknown if social amoebae...περισσότερα »
Evaluation of viability, metabolic activity and spore quantity in Clostridial cultures during ABE fermentation
Flow cytometry, in combination with fluorescent staining, was used to evaluate population heterogeneity in acetone-butanol-ethanol fermentation that was carried out with type strain *Clostridium beijerinckii* NCIMB 8052 and non-type *Clostridium pasteurianum* NRRL B-598. A combination of propidium iodide (PI) and carboxyfluorescein diacetate (CFDA), PI plus Syto-9, and bis-oxonol (BOX) alone were employed to distinguish between active and damaged cells together with simultaneous detection of spores. These strategies provided valuable information on the physiological state of clost... περισσότερα »
CrAgDb - A Database of Annotated Chaperone Repertoire in Archaeal Genomes
Chaperones are a diverse class of ubiquitous proteins that assist other cellular proteins in folding correctly and maintaining their native structure. Many different chaperones cooperate to constitute the "proteostasis" machinery in the cells. It has been proposed earlier that archaeal organisms could be ideal model systems for deciphering the basic functioning of the "protein folding machinery" in higher eukaryotes. Several chaperone families have been characterized in archaea over the years but mostly one protein at a time, making it difficult to decipher the composition and mec... περισσότερα »
Intrinsic characteristics of Min proteins on the cell division of Helicobacter pylori
*Helicobacter pylori* divides in the human stomach resulting in persistent infections and causing various disorders. Bacterial cell division is precisely coordinated by many molecules, including FtsZ and Min proteins. However, the role of Min proteins in *H. pylori* division is poorly understood. We investigated the functional characteristics of Min proteins in wild-type HPK5 and five HPK5-derivative mutants using morphological and genetic approaches. All mutants showed a filamentous shape. However, the bacterial cell growth and viability of three single-gene mutants (*minC*, *min... περισσότερα »
Prevalence and distribution of colonic diverticula assessed with CT colonography (CTC)
Abstract Objectives This study aimed to evaluate the prevalence of colonic diverticula according to age, gender, distribution, disease extension and symptoms with CT colonography (CTC). Methods The study population included 1091 consecutive patients who underwent CTC. Patients with diverticula were retrospectively stratified according to age, gender, clinical symptoms and colonic segment involvement. Extension of colonic diverticula was evaluated using a three-point quantitative scale. Using this data, a multivariate regression analysis was applied to investigate the existence of... περισσότερα »
What Evidence Is There That Gadobutrol Causes Increasing Signal Intensity within the Dentate Nucleus and Globus Pallidus on Unenhanced T1W MRI in Patients with RRMS?
ᅟ *Key Points* • *The study by Stojanov et al does not convincingly support the conclusion that gadobutrol causes higher T1 enhancement in brain on unenhanced MRI* • *The study by Stojanov et al does not rule out confounding factors* • *The study by Stojanov et al has limitations in study design* from #Imaging via alexandrossfakianakis on Inoreader http://ift.tt/1QpVP7H via IFTTT
