Efficacy of the systemic co-administration of vitamin D3 in reversing the inhibitory effects of sodium alendronate on orthodontic tooth movement: A preliminary experimental animal study

alexandrossfakianakis shared this article with you from Inoreader Efficacy of the systemic co-administration of vitamin D3 in reversing the inhibitory effects of sodium alendronate on orthodontic tooth movement: A preliminary experimental animal study Via American Journal of Orthodontics and Dentofacial Orthopedics Publication date: Available online 29 April 2022 Source: American Journal of Orthodontics and Dentofacial Orthopedics Author(s): Mehrnaz Moradinejad, Marzie Yazdi, Seyed Ali Mard, Seyed Mohammad Razavi, Milad Shamohammadi, Fatemeh Shahsanaei, Vahid Rakhshan View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The effectiveness of esketamine and propofol versus dezocine and propofol sedation during gastroscopy: A randomized controlled study

alexandrossfakianakis shared this article with you from Inoreader The effectiveness of esketamine and propofol versus dezocine and propofol sedation during gastroscopy: A randomized controlled study Via Journal of Clinical Pharmacy and Therapeutics This is a flow diagram showing enrollment of participants. A total of 102 patients were enrolled in this study from October to November 2021, 15 patients were excluded, and 87 patients were randomly assigned to receive esketamine or dezocine, but 83 patients completed the study finally (esketamine group n = 42, dezocine group n = 41). Abstract What Is Known and Objective Propofol is widely used in painless gastroscopy. However, sedation with propofol alone might increase the risk of respiratory and circulatory complications. This randomized clinical study compares the efficacy and safety of esketamine or dezocine combined with intravenous (IV) propofol in patients undergoing gastroscopy. Methods A total of 102 patients were enrolled in this study and randomized into two groups. All patients were adults aged 18–64 years who underwent upper gastrointestinal gastroscopy. Patients were randomly assigned to two groups to receive esketamine (0.3 mg/kg) combined with propofol (group E) or dezocine (0.05 mg/kg) combined with propofol (group D). In both groups, the drugs were administered intravenously. The primary outcome was the dose of propofol which provided a satisfactory sedative effect, both to the endoscopist and the patients. Secondary outcomes included recovery time, side effects (such as hypotension, nausea and vomiting and agitation), and the number of adverse circulatory and respiratory events. Results Data of 83 patients were analysed in the present study. Dosage of propofol required in group E (1.44 mg/kg ± 0.67 mg/kg) was significantly lower compared with that in group D (2.12 mg/kg ± 0.37 mg/kg) (p < 0.0001). There was no statistically significant difference in recovery time, side effects, and the frequency of sedation-related adverse events between the two groups. What Is New and Conclusion The study indicates that intravenous injection of propofol and esmketamine is more effective for gastroscopy. Use of esketamine reduces the total amount of propofol required in ASA I–II patients undergoing gastroscopy compared with single use of dezocine. It also provides more stable hemodynamics, without affecting the recovery time and side effects such as respiratory and circulatory adverse events. Trial Registration The study was registered at the Chinese Clinical Trial Registry (www.chictr.org.cn; registration number: ChiCTR2100051814) on 05/10/2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Verapamil down‐regulates iron uptake and up‐regulates divalent metal transporter 1 expression in H9C2 cardiomyocytes

alexandrossfakianakis shared this article with you from Inoreader Verapamil down‐regulates iron uptake and up‐regulates divalent metal transporter 1 expression in H9C2 cardiomyocytes Via Fundamental & Clinical Pharmacology Abstract Belgrade rats have a defect in divalent metal transport 1 (DMT1) with a reduced heart iron, indicating that DMT1 plays a physiological role in non-transferrin-bound iron (NTBI) uptake by cardiomyocytes. However, LVDCC (L-type voltage-dependent Ca2+ channel) blockers were recently demonstrated to significantly reduce NTBI uptake by cardiomyocytes, implying that LVDCC plays a dominant role in NTBI uptake by cardiomyocytes under iron-overloaded conditions. These findings led us to hypothesize that the LVDCC blocker-induced reduction in NTBI uptake might result not only from the inhibition of LVDCC-mediated NTBI uptake but also from the suppression of DMT1-mediated NTBI uptake. We therefore investigated the effects of the LVDCC blocker verapamil on NTBI uptake as well as DMT1 expression in H9C2 cells by the measurement of radio-labeled 55Fe(II), RT-PCR and western blot analysis. We demonstrated that verapamil induced a significant reduction in NTBI uptake by H9C2 cells, but also unexpectedly a remarkable increase rather than decrease in the expression of DMT1 mRNA and protein in H9C2 cells. Our findings imply that the verapamil-induced reduction in NTBI uptake by H9C2 cells is not associated with DMT1, and also indicate that verapamil stimulates rather than inhibits DMT1 expression and DMT1–mediated iron uptake by heart cells. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Level Ib CTV delineation in nasopharyngeal carcinoma based on lymph node distribution and topographic anatomy

alexandrossfakianakis shared this article with you from Inoreader Level Ib CTV delineation in nasopharyngeal carcinoma based on lymph node distribution and topographic anatomy Via radiotheraphy Publication date: Available online 29 April 2022 Source: Radiotherapy and Oncology Author(s): Yue Zhao, Xiongfei Liao, Yiling Wang, Wanying Lan, Jing Ren, Ningjing Yang, Churong Li, Jingyi Lang, Shichuan Zhang View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Relative Vaccine Effectiveness of a SARS-CoV-2 mRNA Vaccine Booster Dose Against the Omicron Variant

alexandrossfakianakis shared this article with you from Inoreader Relative Vaccine Effectiveness of a SARS-CoV-2 mRNA Vaccine Booster Dose Against the Omicron Variant Via Clinical Infectious Diseases Advance Access Abstract Background The current SARS-CoV-2 vaccines may be less effective against the Omicron variant. With recent resurgence of SARS-CoV-2 cases, the role of booster doses of the vaccine needs to be highlighted. Methods Using a retrospective cohort study design emulating a target trial, we determined the relative effectiveness of a homologous booster dose of a SARS-CoV-2 mRNA vaccine compared with primary series alone in preventing infection, hospitalization, a nd intensive care unit (ICU) admission, and death in the Department of Veterans Affairs healthcare system in the US. Among infection-free survivors who received two doses of an mRNA vaccine prior to April 30, 2021, we identified those who received a booster between September 22 and December 25, 2021 and 1:1 matched individuals who did not receive a booster. Results Among 2,384,272 previously uninfected persons with two doses of an mRNA vaccine by April 30, 2021, we identified 462,950 booster recipients between September 22 and December 25, 2021 who were matched 1:1 with non-booster recipients. RVE (95% CI) was 19% (17-22%) for confirmed infection, 52% (46-57%) for hospitalization, and 83% (65-92%) for ICU admission or death. Recipients of the mRNA-1273 vaccine had a lower cumulative incidence of infections and hospitalizations compared with BNT-162b2 vaccine (log-rank p-value <0.001 for both comparisons). Conclusion While the RVE of SARS-CoV-2 mRNA booster vacci ne dose in preventing infection against the Omicron variant is low, the RVE is substantial in preventing hospitalization and high in preventing the most severe/critical disease. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

PET2 response associated with survival in newly diagnosed diffuse large B-cell lymphoma: results of two independent prospective cohorts

alexandrossfakianakis shared this article with you from Inoreader PET2 response associated with survival in newly diagnosed diffuse large B-cell lymphoma: results of two independent prospective cohorts Via Blood Cancer Journal - Issue - nature.com science feeds View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hydroxyl radical is predominantly involved in oxidatively generated base damage to cellular DNA exposed to ionizing radiation

alexandrossfakianakis shared this article with you from Inoreader Hydroxyl radical is predominantly involved in oxidatively generated base damage to cellular DNA exposed to ionizing radiation Via International Journal of Radiation Biology: Table of Contents: Taylor and Francis . View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

PET2 response associated with survival in newly diagnosed diffuse large B-cell lymphoma: results of two independent prospective cohorts

alexandrossfakianakis shared this article with you from Inoreader PET2 response associated with survival in newly diagnosed diffuse large B-cell lymphoma: results of two independent prospective cohorts Via Blood Cancer Journal - Issue - nature.com science feeds Blood Cancer Journal, Published online: 03 May 2022; doi:10.1038/s41408-022-00649-x PET2 response associated with survival in newly diagnosed diffuse large B-cell lymphoma: results of two independent prospective cohorts View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Vocal fold fibroblasts promote angiogenesis in vocal fold leukoplakia by secreting pro-angiogenic factors

alexandrossfakianakis shared this article with you from Inoreader Vocal fold fibroblasts promote angiogenesis in vocal fold leukoplakia by secreting pro-angiogenic factors Via ScienceDirect Publication: Auris Nasus Larynx Publication date: Available online 2 May 2022 Source: Auris Nasus Larynx Author(s): Yinying Chu, Yi Fang, Haitao Wu, Jian Chen, Lei Cheng View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Treatment planning comparison in the PROTECT-trial randomising proton versus photon beam therapy in oesophageal cancer: results from eight european centres

alexandrossfakianakis shared this article with you from Inoreader Treatment planning comparison in the PROTECT-trial randomising proton versus photon beam therapy in oesophageal cancer: results from eight european centres Via radiotheraphy Publication date: Available online 2 May 2022 Source: Radiotherapy and Oncology Author(s): Lone Hoffmann, Hanna Mortensen, Muhammad Shamshad, Maaike Berbee, Nicola Bizzocchi, Rebecca Bütof, Richard Canters, Gilles Defraene, Mai Lykkegaard Ehmsen, Francesca Fiorini, Karin Haustermans, Ryan Hulley, Erik W. Korevaar, Matthew Clarke, Sebastian Makocki, Christina T. Muijs, Luke Murray, Owen Nicholas, Marianne Nordsmark, Ganesh Radhakrishna View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Angled ball and locator attachments for immediate loaded inclined implants used to retain maxillary overdentures: A cross over study of patient satisfaction and oral health related quality of life

alexandrossfakianakis shared this article with you from Inoreader Angled ball and locator attachments for immediate loaded inclined implants used to retain maxillary overdentures: A cross over study of patient satisfaction and oral health related quality of life Via Clinical Implant Dentistry and Related Research Abstract Objectives The aim of this was to compare the influence of two different angulated abutment designs on patient satisfaction, oral health-related quality of life, and prosthetic aspects of implant-supported maxillary overdentures. Materials and Methods For this cross-over study, 18 patients with completely edentulous maxillary ridges opposing implant-retained mandibular overdentures received 4 implants between the maxillary sinuses using computer-guided surgery. The anterior implants were installed at canine/lateral incisor areas and inclined 15° labially. The posterior implants were inserted just anterior to the maxillary sinuses and inclined 15o distally. Eight patients received maxillary overdentures retained by angled ball attachment (ball overdenture [BOD]) and angled locator attachment in random order. After 6 months, patients indicated satisfaction with their prosthesis using a visual analog scale (VAS), and oral health impact profile (OHIP-14). Moreover, postinsertion prosthodontic maintenance and complications were recorded for both attachments. Comparisons of patient satisfaction and prosthetic complications between groups were performed using the Wilcoxon matched-pairs test and the McNemar test, respectively. Results Locator overdenture (LOD) recorded significantly higher scores than the BOD group regarding all the VAS questions except for ease of cleaning (p < 0.007). LOD recorded significantly higher patient satisfaction regarding the pronunciation of sounds (p = 0.009), painful aching (p = 0.018), feeling tense (p = 0.011), unsatisfactory diet (p = 0.013), irritability with people (p = 0.005), and life in general (p = 0.004). The most common complications were matrix activation/renewal (n = 34). BOD showed a significantly higher incidence of attachment loosening (p = 0.002), and teeth fracture (p = 0.049) than LOD. LOD showed a significantly higher incidence of attachment wear and replacement than BOD (p <0.001). There was no difference between groups regarding soft tissue complications. Conclusion Within the limitations of this study, and in terms of improved patient-centered outcomes, angled locator attachments are recommended to retain maxillary implant overdentures opposed by implant retained mandibular overdentures at it was associated with increased patient satisfaction and oral health-related quality of life than angled ball attachments. However, locator attachment was associated with more postinsertion prosthodontic maintenance than ball attachment. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.