Aorto-venous fistula between an abdominal aortic aneurysm and an aberrant renal vein: a case report
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
The potential complications of an abdominal aortic aneurysm include rupture, compression of surrounding structures, thrombo-embolic events and fistula. The most common site of arterio-venous fistula is the inf… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ortvv5 via IFTTT
Retraction: A novel observation of pubic osteomyelitis due to Streptococcus viridans after dental extraction: a case report
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nXE48T via IFTTT
Palliativchirurgie in der Viszeralmedizin
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
Palliativchirurgie in der Viszeralmedizin: Zusammenfassung Hintergrund Der Stellenwert einer Primärtumorresektion in der metastasierten, palliativen Situation wird kontrovers diskutiert. Daten liegen nahezu ausschließlich aus retrospektiven Analysen vor. Prospektiv randomisierte erhobene Studienergebnisse existieren bisher nicht. Ziel der Arbeit Am Beispiel des Magen- und des Rektumkarzinoms werden Ergebnisse einer prospektiven Observationsstudie zur palliativen Primärtumorresektion vorgestellt und im Literaturvergleich […]
Arterial Vasospasm Induced by Electronic Cigarettes Following Microsurgical Breast Reconstruction
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
Can E-Cigarettes Cause Free Flap Failure? A Case of Arterial Vasospasm Induced by Electronic Cigarettes Following Microsurgical Breast Reconstruction: Sir: The vasoconstrictive effects of cigarettes is well documented and routinely discussed with patients seeking microsurgical breast reconstruction. It is generally accepted that patients stop smoking 2–4 weeks before the planned reconstruction to avoid vasoconstriction and […]
Designing Flaps for Closure of Circular and Semicircular Skin Defects
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
Designing Flaps for Closure of Circular and Semicircular Skin Defects: Summary: Removing skin lesions from the human body is a simple procedure, but closing the resulting defect may prove a difficult task. The surgeon quite often encounters a problem when the lesion is located in a confined anatomical area where the elasticity of the skin […]
Can E-Cigarettes Cause Free Flap Failure?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
Can E-Cigarettes Cause Free Flap Failure? A Case of Arterial Vasospasm Induced by Electronic Cigarettes Following Microsurgical Breast Reconstruction: Sir: The vasoconstrictive effects of cigarettes is well documented and routinely discussed with patients seeking microsurgical breast reconstruction. It is generally accepted that patients stop smoking 2–4 weeks before the planned reconstruction to avoid vasoconstriction and […]
Ear Lobule Rejuvenation in Face-Lifting: The Role of Fat Augmentation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
Ear Lobule Rejuvenation in Face-Lifting: The Role of Fat Augmentation: Background: Ear lobule ptosis and deflation are characteristics of facial aging. A rhytidectomy without rejuvenation of a deflated ear lobule may fail to address all aspects of facial aging. Fillers have been used to treat ear lobule deflation; however, autologous fat transfer has never been […]
Surgical Classification of the Mandibular Deformity in Craniofacial Microsomia Using 3-Dimensional Computed Tomography
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
Surgical Classification of the Mandibular Deformity in Craniofacial Microsomia Using 3-Dimensional Computed Tomography: Background: Grading systems of the mandibular deformity in craniofacial microsomia (CFM) based on conventional radiographs have shown low interrater reproducibility among craniofacial surgeons. We sought to design and validate a classification based on 3-dimensional CT (3dCT) that correlates features of the deformity […]
CRM1 and chromosomal passenger complex component survivin are essential to normal mitosis progress and to preserve keratinocytes from mitotic abnormalities
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
CRM1 and chromosomal passenger complex component survivin are essential to normal mitosis progress and to preserve keratinocytes from mitotic abnormalities: Abstract Objective Human epidermis provides the body a barrier against environmental assaults. To assume this function, the epidermis needs the renewal of keratinocytes allowed by constant mitosis, which replace the exfoliating corneocytes. Keratinocyte stem cells […]
Developmental programming, a pathway to disease
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
Endocrinology, Early Release. from Endocrinology via ola Kala on Inoreader http://ift.tt/1Pkmjdd via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QqV6mD via IFTTT
Reviewer acknowledgement 2015
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 16 δευτερόλεπτα
Contributing reviewersThe editors of World Allergy Organization Journal would like to thank all of our reviewers who have contributed to the journal in Volume 8 (2015). from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1T6XrIo via IFTTT
A lurking threat: transfer of peanut allergy through peripheral blood stem cell transplantation
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 16 δευτερόλεπτα
Background: There exist several reports of atopy and allergen-specific IgE-mediated hypersensitivity transferred by bone marrow transplantation, and it has been concluded that the transfer of allergic reactivity results from adoptive transfer of IgE-producing donor-derived B- and/or plasma cells. To the best of our knowledge we report the first case of peanut allergy after PBSCT.Case PresentationA […]
Planning digital artery perforators using color Doppler ultrasonography
: a preliminary report via British Association of Plastic Surgeons Publication date: Available online 8 February 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Kosuke Shintani, Kiyohito Takamatsu, Takuya Uemura, Ema Onode, Mitsuhiro Okada, Kenichi Kazuki, Hiroaki Nakamura Digital artery perforator (DAP) flaps have been applied for the coverage of finger soft tissue defects. While an advantage of this method is that there is no scarification of the digital arteries, it is difficult to identify the location of the perforators during intraoperative elevatio... περισσότερα »
Designing Flaps for Closure of Circular and Semicircular Skin Defects
Designing Flaps for Closure of Circular and Semicircular Skin Defects: [image: image] Summary: Removing skin lesions from the human body is a simple procedure, but closing the resulting defect may prove a difficult task. The surgeon quite often encounters a problem when the lesion is located in a confined anatomical area where the elasticity of the skin is limited or when the lesion is large. To obviate these difficulties, I present 4 new incisions for closure of circular and semicircular skin defects on difficult parts of the human body such as the scalp, face, axilla, back, and sa... περισσότερα »
Arterial Vasospasm Induced by Electronic Cigarettes Following Microsurgical Breast Reconstruction
*Can E-Cigarettes Cause Free Flap Failure? A Case of Arterial Vasospasm Induced by Electronic Cigarettes Following Microsurgical Breast Reconstruction: * Sir: *The vasoconstrictive effects of cigarettes is well documented and routinely discussed with patients seeking microsurgical breast reconstruction. It is generally accepted that patients stop smoking 2–4 weeks before the planned reconstruction to avoid vasoconstriction and to prevent issues with wound healing. Although studies have documented the consequences of cigarette smoking on flap failure and wound healing, no prior s...περισσότερα »
Palliativchirurgie in der Viszeralmedizin
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Palliativchirurgie in der Viszeralmedizin: Zusammenfassung HintergrundDer Stellenwert einer Primärtumorresektion in der metastasierten, palliativen Situation wird kontrovers diskutiert. Daten liegen nahezu ausschließlich aus retrospektiven Analysen vor. Prospektiv randomisierte erhobene Studienergebnisse existieren bisher nicht. Ziel der ArbeitAm Beispiel des Magen- und des Rektumkarzinoms werden Ergebnisse einer prospektiven Observationsstudie zur palliativen Primärtumorresektion vorgestellt und im Literaturvergleich diskutiert. MethodeBasierend auf den am „An-Institut für Qu...περισσότερα »
CRM1 and chromosomal passenger complex component survivin are essential to normal mitosis progress and to preserve keratinocytes from mitotic abnormalities
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
CRM1 and chromosomal passenger complex component survivin are essential to normal mitosis progress and to preserve keratinocytes from mitotic abnormalities: Abstract Objective Human epidermis provides the body a barrier against environmental assaults. To assume this function, the epidermis needs the renewal of keratinocytes allowed by constant mitosis, which replace the exfoliating corneocytes. Keratinocyte stem cells (KSCs) located in the basal epidermis are mitotically active, self-renewing and govern the epithelial stratification by producing renewed source of keratinocytes. Pro...περισσότερα »
Metastasenchirurgie – anatomische und ethische Grenzen
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Metastasenchirurgie – anatomische und ethische Grenzen: ZusammenfassungAufgrund interdisziplinärer, multimodaler Therapieoptionen ist die Resektion von Metastasen heute bei ausgewählten Patienten mit multilokulärer Metastasierung sinnvoll. Anatomische Grenzen scheinen dabei durch Verwendung moderner chirurgischer Operationstechniken zu verschwinden. Die Spezifizierung der Eingriffe durch exakte präoperative Diagnostik ermöglicht komplexe Operationen mit überschaubarer Komplikationsrate. Dennoch ist Umsicht geboten, da nicht jede technisch machbare Metastasenresektion letztlich auch... περισσότερα »
Can E-Cigarettes Cause Free Flap Failure?
Can E-Cigarettes Cause Free Flap Failure? A Case of Arterial Vasospasm Induced by Electronic Cigarettes Following Microsurgical Breast Reconstruction: Sir: The vasoconstrictive effects of cigarettes is well documented and routinely discussed with patients seeking microsurgical breast reconstruction. It is generally accepted that patients stop smoking 2–4 weeks before the planned reconstruction to avoid vasoconstriction and to prevent issues with wound healing. Although studies have documented the consequences of cigarette smoking on flap failure and wound healing, no prior study ...περισσότερα »
Ear Lobule Rejuvenation in Face-Lifting: The Role of Fat Augmentation
Ear Lobule Rejuvenation in Face-Lifting: The Role of Fat Augmentation: [image: image]Background: Ear lobule ptosis and deflation are characteristics of facial aging. A rhytidectomy without rejuvenation of a deflated ear lobule may fail to address all aspects of facial aging. Fillers have been used to treat ear lobule deflation; however, autologous fat transfer has never been utilized for ear lobule rejuvenation. This investigation studies the success of autologous fat transfer to the ear lobule as part of volume augmentation rhytidectomy. Methods: A retrospective review of patients w... περισσότερα »
Surgical Classification of the Mandibular Deformity in Craniofacial Microsomia Using 3-Dimensional Computed Tomography
Surgical Classification of the Mandibular Deformity in Craniofacial Microsomia Using 3-Dimensional Computed Tomography: [image: image]Background: Grading systems of the mandibular deformity in craniofacial microsomia (CFM) based on conventional radiographs have shown low interrater reproducibility among craniofacial surgeons. We sought to design and validate a classification based on 3-dimensional CT (3dCT) that correlates features of the deformity with surgical treatment. Methods: CFM mandibular deformities were classified as normal (T0), mild (hypoplastic, likely treated with ortho...περισσότερα »
Cytotoxic effects of SMAC-mimetic compound LCL161 in head and neck cancer cell lines
Cytotoxic effects of SMAC-mimetic compound LCL161 in head and neck cancer cell lines: Abstract ObjectivesHead and neck squamous cell carcinoma (HNSCC) is one of the most common tumor entities worldwide. Unfortunately, recent drug developments in other fields of oncology have yielded no efficacy in the treatment of oral squamous cell carcinoma. As a new starting point, we investigated the impact of Fas ligand (FasL) and the SMAC-mimetic compound LCL161 in mono- and combination treatment in HNSCC cell lines. MethodsFive different cell lines of HNSCC were treated with FasL and LCL...περισσότερα »
The Child Oral Health Impact Profile
Confirmatory factor analysis of the Child Oral Health Impact Profile (Korean version): Empirical support for the factor structure of the Child Oral Health Impact Profile (COHIP) has not been fully established. The purposes of this study were to evaluate the factor structure of the Korean version of the COHIP (COHIP-K) empirically using confirmatory factor analysis (CFA) based on the theoretical framework and then to assess whether any of the factors in the structure could be grouped into a simpler single second-order factor. Data were collected through self-reported COHIP-K respons... περισσότερα »
I-124 PET/CT IN PATIENTS WITH DIFFERENTIATED THYROID CANCER: CLINICAL AND QUANTITATIVE IMAGE ANALYSIS.
*I-124 PET/CT IN PATIENTS WITH DIFFERENTIATED THYROID CANCER: CLINICAL AND QUANTITATIVE IMAGE ANALYSIS.* Thyroid. 2016 Feb 9; Authors: Gulec SA, Kuker RA, Goryawala M, Fernandez C, Perez R, Khan-Ghany A, Apaza A, Harja E, Harrell M Abstract BACKGROUND: Although radioactive iodine (RAI) imaging/therapy is one of the earliest applications of theranostics, there still remain a number of unresolved clinical questions as to the optimization of diagnostic techniques/protocols as well as improvements in patient-specific treatment planning strategies. The objectives of this study are to ... περισσότερα »
Differential Effects of Teriparatide and Denosumab on Intact PTH and Bone Formation Indices: AVA Osteoporosis Study.
*Differential Effects of Teriparatide and Denosumab on Intact PTH and Bone Formation Indices: AVA Osteoporosis Study.* J Clin Endocrinol Metab. 2016 Feb 9;:jc20154181 Authors: Dempster DW, Zhou H, Recker RR, Brown JP, Recknor CP, Lewiecki EM, Miller PD, Rao SD, Kendler DL, Lindsay R, Krege JH, Alam J, Taylor KA, Janos B, Ruff VA Abstract CONTEXT: Denosumab-induced parathyroid hormone (PTH) elevation may stimulate early bone formation. OBJECTIVE: Evaluate whether denosumab-induced changes of intact (i)PTH result in early anabolic effects according to histomorphometry and bone turn... περισσότερα »
Cytotoxic effects of SMAC-mimetic compound LCL161 in head and neck cancer cell lines
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Cytotoxic effects of SMAC-mimetic compound LCL161 in head and neck cancer cell lines: Abstract ObjectivesHead and neck squamous cell carcinoma (HNSCC) is one of the most common tumor entities worldwide. Unfortunately, recent drug developments in other fields of oncology have yielded no efficacy in the treatment of oral squamous cell carcinoma. As a new starting point, we investigated the impact of Fas ligand (FasL) and the SMAC-mimetic compound LCL161 in mono- and combination treatment in HNSCC cell lines. MethodsFive different cell lines of HNSCC were treated with FasL and LCL1...περισσότερα »
THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma
THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma: Background THBS1 (thrombospondin-1) is the extracellular matrix (ECM) protein that affects diverse cellular activities. It constitutes the tumor stroma, but the role of THBS1 in oral squamous cell carcinoma (OSCC) development is unclear. The aim of this study was to clarify the relevance of THBS1 in the pathogenesis of OSCC. Materials and methods The expression of THBS1 was examined in 44 OSCC by immunohistochemical analysis and in 43 OSCC by cDNA microarray analysis. Cell culture ...περισσότερα »
G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis
G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis: by Run Lei, Ke Zhang, Yanxia Wei, Min Chen, Lee S. Weinstein, Yang Hong, Minyan Zhu, Hongchang Li, Huashun Li The heterotrimeric G protein subunit Gsα couples receptors to activate adenylyl cyclase and is required for the intracellular cAMP response and protein kinase A (PKA) activation. Gsα is ubiquitously expressed in many cell types; however, the role of Gsα in neural crest cells (NCCs) remains unclear. Here we report that NCCs-specific *Gsα* knockout mice die within hours after birth and exhibit dramatic cranio... περισσότερα »
Pluripotent Stem Cells and Other Innovative Strategies for the Treatment of Ocular Surface Diseases
Pluripotent Stem Cells and Other Innovative Strategies for the Treatment of Ocular Surface Diseases: AbstractThe cornea provides two thirds of the refractive power of the eye and protection against insults such as infection and injury. The outermost tissue of the cornea is renewed by stem cells located in the limbus. Depletion or destruction of these stem cells may lead to blinding limbal stem cell deficiency (LSCD) that concerns millions of patients around the world. Innovative strategies based on adult stem cell therapies have been developed in the recent years but they are still... περισσότερα »
Osteogenic Behavior of Mesenchymal Stromal Cells
Effect of Nano-HA/Collagen Composite Hydrogels on Osteogenic Behavior of Mesenchymal Stromal Cells: AbstractThis study aimed to comparatively evaluate the in vitro effect of nanosized hydroxyapatite and collagen (nHA/COL) based composite hydrogels (with different ratios of nHA and COL) on the behavior of human mesenchymal stromal cells (MSCs), isolated from either adipose tissue (AT-MSCs) or bone marrow (BM-MSCs). We hypothesized that (i) nHA/COL composite hydrogels would promote the osteogenic differentiation of MSCs in an nHA concentration dependent manner, and that (ii) AT-MSCs ... περισσότερα »
Disparate Response to Methotrexate in Stem Versus Non-Stem Cells
Disparate Response to Methotrexate in Stem Versus Non-Stem Cells: AbstractMethotrexate (MTX) is a commonly used chemotherapeutic agent that kills cancer cells by binding dihydrofolate reductase (DHFR) as a competitive inhibitor. Due to its non-selectivity, MTX also impairs normal (non-cancerous) cell function and causes long-term damage to healthy tissue. These consequences have been investigated extensively in bone-derived cells due to their sensitivity to the drug. While DHFR likely plays a role in normal cell response to MTX, research in this area is limited. Moreover, how MTX s...περισσότερα »
Replacement of Lost Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters
Replacement of Lost Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters: [image: article_notepad.gif] In this article, Tetteh et al. show that enterocyte-lineage progenitors can become stem cells during intestinal regeneration. Additionally, these cells generate Paneth-like cells and turn on genes that promote recovery from injury. In sum, “stemness” in intestinal crypts is not “hard-wired;” many progenitors can regain stemness upon loss of the actual stem cells.
Stem and Progenitor Cell-Based Therapy of the Central Nervous System
: Hopes, Hype, and Wishful Thinking via Cell Stem Cell Publication date: 4 February 2016 *Source:*Cell Stem Cell, Volume 18, Issue 2 Author(s): Steven A. Goldman A variety of neurological disorders are attractive targets for stem and progenitor cell-based therapy. Yet many conditions are not, whether by virtue of an inhospitable disease environment, poorly understood pathophysiology, or poor alignment of donor cell capabilities with patient needs. Moreover, some disorders may be medically feasible targets but are not practicable, in light of already available treatments, poor risk-ben... περισσότερα »
NFκB is one of the central regulators of cell survival, immunity, inflammation, carcinogenesis and organogenesis
TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin: AbstractNFκB is one of the central regulators of cell survival, immunity, inflammation, carcinogenesis and organogenesis. The activation of NFκB is strictly regulated by several posttranslational modifications including phosphorylation, neddylation and ubiquitination. Several types of ubiquitination play important roles in multi-step regulations of the NFκB pathway. Some of the tripartite motif-containing (TRIM) proteins functioning as E3 ubiquitin ligases are known to regulate various ... περισσότερα »
Collagen-induced arthritis
Aortic VCAM-1: an early marker of vascular inflammation in collagen-induced arthritis: Abstract Cardiovascular disease (CVD) is a major cause of morbidity and mortality in rheumatoid arthritis (RA). There are limited experimental data on vascular involvement in arthritis models. To study the link between CVD and inflammation in RA, we developed a model of vascular dysfunction and articular inflammation by collagen-induced arthritis (CIA) in C57Bl/6 (B6) mice. We studied the expression of vascular inflammatory markers in CIA with and without concomitant hyperlipidic diet (HD). Colla...περισσότερα »
Prognostic significance of EZH2 expression in patients with oesophageal cancer: a meta-analysis
Prognostic significance of EZH2 expression in patients with oesophageal cancer: a meta-analysis: Abstract Enhancer of zeste 2 (EZH2), a key component of polycomb repressive complex 2 (PRC2), was of great importance in human cancer pathogenesis. Various studies examined the relationship between EZH2 overexpression with the clinical outcome in patients with digestive cancers, but yielded conflicting results. Electronic databases updated to January 2015 were searched to find relevant studies. A meta-analysis was conducted with eligible studies which quantitatively evaluated the relati...περισσότερα »
Naringenin targets ERK2 and suppresses UVB-induced photoaging
Naringenin targets ERK2 and suppresses UVB-induced photoaging: Abstract A number of natural phytochemicals have anti-photoaging properties that appear to be mediated through the inhibition of matrix metalloproteinase-1 (MMP-1) expression, but their direct target molecule(s) and mechanism(s) remain unclear. We investigated the effect of naringenin, a major flavonoid found in citrus, on UVB-induced MMP-1 expression and identified its direct target. The HaCaT human skin keratinocyte cell line and 3-dimensional (3-D) human skin equivalent cultures were treated or not treated with naring...περισσότερα »
Madelung's disease is a neglected metabolic disease characterised by generalised multiple fatty tissue deposits
State of diagnostic quandary solved by modern technology: a rare case of Madelung's disease: Madelung's disease is a neglected metabolic disease characterised by generalised multiple fatty tissue deposits. A 64-year-old Caucasian woman presented with generalised weakness and symptomatic hypoglycaemia with altered mental status. Physical examination showed very distinct physical characteristics with multiple lumps distributed over the upper body. Her neurological symptoms were solved by giving intravenous glucose and optimisation of medical treatment. Even though she had unique cha... περισσότερα »
Prognostic significance of EZH2 expression in patients with oesophageal cancer: a meta-analysis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Prognostic significance of EZH2 expression in patients with oesophageal cancer: a meta-analysis: Abstract Enhancer of zeste 2 (EZH2), a key component of polycomb repressive complex 2 (PRC2), was of great importance in human cancer pathogenesis. Various studies examined the relationship between EZH2 overexpression with the clinical outcome in patients with digestive cancers, but yielded conflicting results. Electronic databases updated to January 2015 were searched to find relevant studies. A meta-analysis was conducted with eligible studies which quantitatively evaluated the relati...περισσότερα »
Right paratracheal mass.Infrahepatic inferior vena cava (IVC) interruption with azygos continuation
Right paratracheal mass on chest X-ray: an important part of the checklist before cardiac catheterisation: Description Infrahepatic inferior vena cava (IVC) interruption with azygos continuation is a rare congenital anomaly with a prevalence of 0.6–2.0% in patients with congenital heart disease.1 Many of these patients are expected to undergo cardiac catheterisation through the femoral vein. For this, the catheter must pass up the IVC to the azygos vein and then down into the superior vena cava (SVC), making the procedure technically more difficult. A 19-year-old male patient with p...περισσότερα »
What is the safe upper intake level of folic acid for the nervous system? Implications for folic acid fortification policies
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
What is the safe upper intake level of folic acid for the nervous system? Implications for folic acid fortification policies European Journal of Clinical Nutrition advance online publication, February 10 2016. doi:10.1038/ejcn.2015.231 Author: E H Reynolds from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20VcEyI via IFTTT
Reliability of 24-h void frequency as an index of hydration status when euhydrated and hypohydrated
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Reliability of 24-h void frequency as an index of hydration status when euhydrated and hypohydrated European Journal of Clinical Nutrition advance online publication, February 10 2016. doi:10.1038/ejcn.2015.233 Authors: M A Tucker, M A Gonzalez, J D Adams, J M Burchfield, N E Moyen, F B Robinson, B A Schreiber & M S Ganio from #Medicine-SfakianakisAlexandros […]
CAR T-cell therapy: opportunities and challenges
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Immunotherapy Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20VcCqw via IFTTT
Sarilumab for the treatment of rheumatoid arthritis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Immunotherapy Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TcazNz via IFTTT
Immune checkpoint therapy for non-small-cell lung cancer: an update
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Immunotherapy Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20VcBTK via IFTTT
Future directions in bladder cancer immunotherapy: towards adaptive immunity
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Immunotherapy Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20VcE1E via IFTTT
A review of allergoid immunotherapy: is cat allergy a suitable target?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
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In situ vaccination for the treatment of cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Immunotherapy Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20VcDLf via IFTTT
Harnessing B cells in immunotherapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Immunotherapy Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TcaB83 via IFTTT
Interleukin-2: a double-edge sword in allogeneic stem cell transplantation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Immunotherapy Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20VcDuF via IFTTT
A mild form of dermatomyositis as a prodromal sign of lung adenocarcinoma: a case report
A mild form of dermatomyositis as a prodromal sign of lung adenocarcinoma: a case report: Background: Dermatomyositis is an idiopathic connective tissue disease characterized by specific cutaneous findings and inflammatory lesions in the muscle biopsy. An association between dermatomyositis and malignancy, including breast, ovarian, lung and colon cancer was recognized many years ago, with an incidence of malignancy in approximately 20 % of cases. Dermatomyositis is hypothesized to be an autoimmune reaction against factors or hormones secreted by the tumor; however, the exact autoimm... περισσότερα »
Use of Scrambler Therapy in Acute Paediatric Pain
*Use of Scrambler Therapy in Acute Paediatric Pain: A Case Report and Review of the Literature: We report our clinical experience on the effect of Scrambler Therapy (ST) for a child with acute mixed pain refractory to pharmacological treatment. ST, recently proposed as an alternative treatment for chronic neuropathic pain in adults, is a noninvasive approach to relieve pain, by changing pain perception at brain level. It is safe and has no side effects. Further research is needed to assess its efficacy for acute pain and for paediatric population.* Welcome to the Scrambler Therapy o...περισσότερα »
Reversed halo sign in cryptogenic organising pneumonia
Reversed halo sign in cryptogenic organising pneumonia: Description A 60-year-old woman on no medication, with no obvious exposures and no extrapulmonary symptoms, was referred to diagnostic evaluation due to recurrent pneumonia-like episodes for 6 months. Broad biochemistry, autoimmunology and a body plethysmography were normal. Repeatable chest X-rays found diffuse migratory opacities of pneumonic appearance with mild fluor-18-deoxyglucose metabolic activity on a positron emission tomography scan. Bronchoalveolar lavage fluid revealed lymphocytosis of 57% with a CD4/CD8 ratio of 1... περισσότερα »
Extensive and ulcerated malignant proliferating trichilemmal (pilar) tumour, arising from multiple, large, degenerated trichilemmal (pilar) cysts
Extensive and ulcerated malignant proliferating trichilemmal (pilar) tumour, arising from multiple, large, degenerated trichilemmal (pilar) cysts: We report a rare case of a 61-year-old homeless man with a 15-year history of multiple trichilemmal cysts that served as a forerunner for the emergence of a malignant proliferating pilar tumour. The patient presented multiple, large, purulent, ulcerated lesions ranging from 10 to 150 mm in diameter, covering most of the scalp, with large areas superimposed by extensive myiasis infestation. The patient presented with no other major clini...περισσότερα »
What happens in vagus: a case of recurrent paraganglioma with malignant transformation and an updated treatment algorithm
What happens in vagus: a case of recurrent paraganglioma with malignant transformation and an updated treatment algorithm: Paragangliomas (PGLs) are rare, extra-adrenal tumors, originating from neural crest cells and can occur anywhere from the skull base to the pelvic floor. Although these tumors are often benign, a fraction of malignant cases exist. Few isolated cases of malignant head and neck PGL are reported in the literature. Treatment algorithms rely heavily on retrospective case studies and institutional experience. We report an unusual case of an extensive, hereditary PGL,...περισσότερα »
Actinomycosis arising from the nasal cavity
Actinomycosis arising from the nasal cavity, with rare fatal progression: Actinomycosis is a common treatable disease caused by *Actinomyces*, and generally has a good prognosis. However, we report a fatal case of actinomycosis of the nasal cavity. A 54-year-old man, reporting of left nasal obstruction, swelling and sharp pain around the root of the nose, was referred to our hospital. Histopathological examinations led to a definitive diagnosis of actinomycosis, and oral antibiotics were administered in an outpatient setting. However, the patient discontinued follow-up at the outpa... περισσότερα »
Ventricular Fibrillation
The "incidental" episode of ventricular fibrillation: a case report: [image: 13256_2006_Article_72_Fig1_HTML.jpg] Polymorphic ventricular tachycardia and ventricular fibrillation (VF) carry important prognostic implications, especially in the post myocardial infarction period. However, artifact on the electrocardiographic...
Decreased levels of aquaporin-4 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension
Decreased levels of aquaporin-4 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension: Background Idiopathic intracranial hypertension is characterized by increased intracranial pressure. Its pathogenesis is largely unknown. Aquaporins may play a role in the homeostasis of cerebrospinal fluid. Methods We aimed to elucidate the role of aquaporins in idiopathic intracranial hypertension by measuring the level of aquaporin-1 and aquaporin-4 in the cerebrospinal fluid and plasma of 28 patients and 29 controls by enzyme-linked immunosorbent assay. The adipokin... περισσότερα »
Gray matter changes related to medication overuse in patients with chronic migraine
Gray matter changes related to medication overuse in patients with chronic migraine: Objective The objective of this article is to investigate the neurological substrates associated with medication overuse (MO) in patients with chronic migraine (CM). Methods We recruited age- and sex-matched CM patients with MO (CMwMO), CM patients without MO (CMwoMO), and healthy controls (HCs). Magnetic resonance T1-weighted images were processed by voxel-based morphometry, and the findings were correlated with clinical variables and treatment responses. Results A total of 66 patients with CM (...περισσότερα »
Migraine is related to an increased risk of Parkinsons disease: A population-based, propensity score-matched, longitudinal follow-up study
Migraine is related to an increased risk of Parkinsons disease: A population-based, propensity score-matched, longitudinal follow-up study: Background The association between migraine and Parkinson’s disease (PD) remains controversial. The purpose of the present population-based, propensity score-matched follow-up study was to investigate whether migraineurs are at a higher risk of developing PD. Methods A total of 41,019 subjects aged between 40 and 90 years with at least two ambulatory visits with a diagnosis of migraine in 2001 were enrolled in the migraine group. A logistic re... περισσότερα »
The phenotype of migraine with unilateral cranial autonomic symptoms documents increased peripheral and central trigeminal sensitization. A case series of 757 patients
The phenotype of migraine with unilateral cranial autonomic symptoms documents increased peripheral and central trigeminal sensitization. A case series of 757 patients: Background Migraine with unilateral cranial autonomic symptoms (UAS) is a putative migraine endophenotype with convincing response to trigeminal-targeted treatments that still needs a thorough characterization. Objective The objective of this article is to carefully investigate the clinical phenotype of migraine with UAS in a large group of patients for more accurate migraine diagnoses, improved clinical management,... περισσότερα »
Exosomes: potential for early detection in pancreatic cancer
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Activation of MEK1/2-ERK1/2 signaling during NNK-induced lung carcinogenesis in female A/J mice
Abstract The extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway is activated by several growth factors and mitogens, and upregulation has been noted in many human cancers, including examples in the lung. In this study, to study the association of ERK1/2 activation with mutation of *Kras* encoding an upstream activator of ERK1/2 in lung premalignant lesions, we immunohistochemically examined expression of phosphorylated forms of ERK1/2 (pERK1/2) and MAP/ERK kinase 1/2 (pMEK1/2) proteins and correlation between ERK activation and mutation of *Kras* encoding an upstr...περισσότερα »
MicroRNA-21 induces 5-fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4
Abstract Pancreatic cancer patients are often resistant to chemotherapy treatment, which results in poor prognosis. The objective of this study was to delineate the mechanism by which miR-21 induces drug resistance to 5-fluorouracil (5-FU) in human pancreatic cancer cells (PATU8988 and PANC-1). We report that PATU8988 cells resistant to 5-FU express high levels of miR-21 in comparison to sensitive primary PATU8988 cells. Suppression of miR-21 expression in 5-Fu-resistant PATU8988 cells can alleviate its 5-FU resistance. Meanwhile, lentiviral vector-mediated overexpression of miR-2...περισσότερα »
Kinetics of postdiagnosis platelet count with overall survival of pancreatic cancer: a counting process approach
Abstract The association between long-term variation of postdiagnosis platelets and survival of pancreatic cancer (PC) has never been discussed by using dynamic survival analysis method. In this retrospective study, we analyzed 311 histologically confirmed PC patients identified from a mega population-based electronic inpatients database from 2012 to 2013 in China. Counting process approach was applied to restructure the original survival data, the association between post-diagnosis platelet count and overall survival (OS) of PC was evaluated by multiple failure-time Cox proportion... περισσότερα »
Radiation-induced mesothelioma among long-term solid cancer survivors: a longitudinal analysis of SEER database
Abstract We investigated the association between external beam radiotherapy (EBRT) and pleural and peritoneal mesothelioma among long-term (>5 years) solid cancer survivors. We analyzed data from the US Surveillance, Epidemiology, and End Results (SEER) program (1973–2012). We fitted survival models adjusted by age, gender, race, year, surgery, and relative risk of primary mesothelioma in the county of residence (proxy for individual asbestos exposure). We estimated hazard ratios [HR] with reference to nonirradiated patients. We distinguished between scattered and direct irradiatio... περισσότερα »
Associations between advanced cancer patients' survival and family caregiver presence and burden
Abstract We conducted a randomized controlled trial (RCT) of an early palliative care intervention (ENABLE: Educate, Nurture, Advise, Before Life Ends) for persons with advanced cancer and their family caregivers. Not all patient participants had a caregiver coparticipant; hence, we explored whether there were relationships between patient survival, having an enrolled caregiver, and caregiver outcomes prior to death. One hundred and twenty-three patient-caregiver dyads and 84 patients without a caregiver coparticipant participated in the ENABLE early versus delayed (12 weeks later... περισσότερα »
Blood gene expression studies in migraine: Potential and caveats
Blood gene expression studies in migraine: Potential and caveats: Background Global gene expression analysis may be used to obtain insights into the functional processes underlying migraine. However, there is a shortage of high-quality post-mortem brain tissue samples for genetic analysis. One approach is to use a more accessible tissue as a surrogate, such as peripheral blood. Purpose Discuss the benefits and caveats of blood genomic profiling in migraine and its potential application in the development of biomarkers of migraine susceptibility and outcome. Demonstrate the utility ... περισσότερα »
Is tasting innate?
Is tasting innate? Authors: Spielman AI, Brand J Abstract Unique features of the sense of taste have engendered two major hypotheses on how the brain recognizes and classifies taste stimuli. These two hypotheses are both based on the same data set: the ability to recognize a large number of stimuli, yet to perceptually classify each within 5 primary qualities. A point of contention for years has been the manner in which our brain accomplishes this task. One idea considers that perception involves the "reading" of a complex pattern or array of excited neurons. Because of the comple... περισσότερα »
Hereditary gingival fibromatosis
Hereditary gingival fibromatosis with extreme ridge thickness and insufficient interarch distance via The Journal of Prosthetic Dentistry Publication date: Available online 10 February 2016 *Source:*The Journal of Prosthetic Dentistry Author(s): Pierre-Luc Michaud, Aditya Patel Hereditary gingival fibromatosis is a rare genetic disorder resulting in gingival overgrowth that can be found in both dental arches. As a result of the gingival overgrowth and associated dental displacement, affected patients occasionally present with increased occlusal vertical dimension and/or inadequate lip ... περισσότερα »
Low-level laser irradiation effect on endothelial cells under conditions of hyperglycemia
Low-level laser irradiation effect on endothelial cells under conditions of hyperglycemia: AbstractDiabetes mellitus is considered to be a very serious lifestyle disease leading to cardiovascular complications and impaired wound healing observed in the diabetic foot syndrome. Chronic hyperglycemia is the source of the endothelial activation. The inflammatory process in diabetes is associated with the secretion of inflammatory cytokines by endothelial cells, e.g., tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6). The method of phototherapy using laser beam of low power (... περισσότερα »
Is there a protocol in experimental skin wounds in rats using low-level diode laser therapy (LLDLT) combining or not red and infrared wavelengths? Systematic review
Is there a protocol in experimental skin wounds in rats using low-level diode laser therapy (LLDLT) combining or not red and infrared wavelengths? Systematic review: AbstractA systematic review addressing experiments with healing of skin wounds in rats using LLDLT with different active means seeking to identify a pattern in adjustments such as laser wavelength, power and fluency and analysing wound healing parameters, such as wound area, presence of fibroblasts, angiogenesis, leukocyte infiltration, epithelial coverage and antibacterial effect. It was perceived that a protocol does... περισσότερα »
Low-level laser therapy on oxidative stress and functional fitness in aged
The effect of low-level laser therapy on oxidative stress and functional fitness in aged rats subjected to swimming: an aerobic exercise: AbstractThe aim of the present study was to determine whether low-level laser therapy (LLLT) in conjunction with aerobic training interferes with oxidative stress, thereby influencing the performance of old rats participating in swimming. Thirty Wistar rats (*Norvegicus albinus*) (24 aged and six young) were tested. The older animals were randomly divided into aged-control, aged-exercise, aged-LLLT, aged-LLLT/exercise, and young-control. Aerobic ... περισσότερα »
Q-switched alexandrite laser and Q-switched Nd:YAG laser on nevus of Ota
Comparison of clinical efficacy and complications between Q-switched alexandrite laser and Q-switched Nd:YAG laser on nevus of Ota: a systematic review and meta-analysis: AbstractAlthough the application of Q-switched lasers on nevus of Ota (OTA) is well demonstrated, debates about clinical option between Q-switched alexandrite laser (QSA) and Q-switched Nd:YAG laser (QSNY) still remain. This systematic review and meta-analysis estimated the overall successful rate of OTA pigment clearance and complication rate of QSA and QSNY and evaluated which laser could produce a better result...περισσότερα »
Pulsed dye laser treatment of paediatric port wine stains
Pulsed dye laser treatment of paediatric port wine stains—variation of practice in the UK (NHS):
Oral Microbiome: Contributions to Local and Systemic Infections
Oral Microbiome: Contributions to Local and Systemic Infections: AbstractThe recent revolution of diagnostic methods emphasizing non-culture techniques has redefined the oral microbiota, its “Dual Citizenship”, recognizing oral flora inhabitants of eight dispersed locations are colonized by over 700 species, equal in bacteria (16S) and fungi (18S). Either prefers the attached biofilm phenotype, biotic or abiotic surfaces, its extra polymeric substance (EPS) protected environment promoting horizontal gene transfer (HGT), and gene amplified resistance. The biofilm growth pattern mimi...περισσότερα »
Peri-implant mucosal thickness by site
A diversity of peri-implant mucosal thickness by site: [image: cover.gif?v=1&s=be74442fea687c39b7fdfa63] Abstract Objectives The objective of this study was to examine peri-implant mucosal thickness at different sites of peri-implant crevice around 70 implants placed in 35 patients. Material and methods The peri-implant mucosal thickness was defined as distance of the peri-implant mucosal margin and the coronal edge of bone/implant contact and measured using the cast models and dental radiography. Results The overall mean peri-implant mucosal thickness was 3.6 ± 1.4 mm, wherein m...περισσότερα »
Disinfection of titanium surfaces
An in vitro study on disinfection of titanium surfaces: Abstract Objective The aim of this *in vitro* study was to evaluate the efficacy of different methods used for the decontamination of titanium surfaces previously infected with a *Staphylococcus aureus* biofilm. Materials and Methods *S. aureus* biofilms were grown on three different titanium surfaces (*n = *114); polished, sandblasted large-grit acid-etched (SLA) and SLActive. The experimental groups were divided into six different disinfection modalities as follows: (i) rinsing with phosphate-buffered saline, (ii) rinsing with... περισσότερα »
Horizontal mucosal thickness at implant sites as it correlates with the integrity and thickness of the buccal bone plate
Horizontal mucosal thickness at implant sites as it correlates with the integrity and thickness of the buccal bone plate: [image: cover.gif?v=1&s=be74442fea687c39b7fdfa63] Abstract Objectives To histologically assess the association between the horizontal mucosal thickness (MT) at implant sites with the integrity and thickness of the buccal bone plate in a canine model. Materials and methods Two-piece titanium implants were placed at chronic-type lateral ridge defects. The resulting vestibular dehiscence-type defects (vertical dimensions of 2–8 mm) were left untreated. After a su... περισσότερα »
Contamination of titanium surfaces and disinfection protocols
Experimental models for contamination of titanium surfaces and disinfection protocols: [image: cover.gif?v=1&s=be74442fea687c39b7fdfa63] Abstract Aim The aim of this pilot study was to describe an *in vitro* model of peri-implantitis microcosm for contamination of titanium surfaces and an *in vivo* model for evaluating different disinfection strategies of titanium surfaces. Materials and methods Biofilms were grown *in vitro* for 30 days on sandblasted large-grit acid-etched (SLA) Ti discs (*n* *=* 69) in a constant depth film fermentor (CDFF) associated with peri-implantitis co... περισσότερα »
American Neurotology Society.
Fifty Years of the American Neurotology Society.: Last year (2015) marked the 50th Anniversary of the American Neurotology Society (ANS). The past 50 years has observed significant progress in the fields of otology and neurotology. Progress did not come without controversies and conflicts. Nonetheless, the ANS flourished throughout this time. To isolate the workings of the ANS from the broader fields of otology and neurotology would be impossible-members of the ANS were and continue to be the leaders in the field, and the topics presented at the ANS meetings reflect its leading edge...περισσότερα »
Enhancing Tissue in the Internal Auditory Canal After Retrosigmoid Vestibular Schwannoma Resection.
Enhancing Tissue in the Internal Auditory Canal After Retrosigmoid Vestibular Schwannoma Resection.:
Endoscopically Guided Transtympanic Balloon Catheter Dilatation of the Eustachian Tube: A Cadaveric Pilot Study.
Endoscopically Guided Transtympanic Balloon Catheter Dilatation of the Eustachian Tube: A Cadaveric Pilot Study.: Objective: To assess the feasibility, safety, and efficacy of transtympanic balloon catheter dilatation of the Eustachian tube (ET) in a cadaver model. Patients and Interventions: A cadaveric study of 10 cadaver heads, which underwent unilateral transtympanic dilatation of the ET with a 3 x 20 mm balloon catheter with full endoscopic guidance and visualization. Results: Procedural safety was demonstrated, with no damage to any essential structures found. Feasibility of the...περισσότερα »
Intratympanic Iodine Contrast Injection Diffuses Across the Round Window Membrane Allowing for Perilymphatic CT Volume Acquisition Imaging.
Intratympanic Iodine Contrast Injection Diffuses Across the Round Window Membrane Allowing for Perilymphatic CT Volume Acquisition Imaging.: Hypothesis: Whether the round window membrane (RWM) is permeable to iodine-based contrast agents (IBCA) is unknown; therefore, our goal was to determine if IBCAs could diffuse through the RWM using CT volume acquisition imaging. Introduction: Imaging of hydrops in the living human ear has attracted recent interest. Intratympanic (IT) injection has shown gadolinium's ability to diffuse through the RWM, enhancing the perilymphatic space. Methods: F...περισσότερα »
Intraoperative Real-time Cochlear Response Telemetry Predicts Hearing Preservation in Cochlear Implantation.
Intraoperative Real-time Cochlear Response Telemetry Predicts Hearing Preservation in Cochlear Implantation.: Aim: To monitor cochlear function during cochlear implantation and determine correlations with postoperative acoustic hearing. Background: Cochlear response telemetry measures cochlear function directly from cochlear implant electrodes. We have adapted this system to provide real-time cochlear response telemetry (RT-CRT) monitoring of a patient's acoustic hearing as the cochlear implant electrode array is inserted. Methods: Eighteen subjects (1 child and 17 adults) with slopin...περισσότερα »
Sialendoscopy-assisted transfacial surgery for the removal of an iatrogenic foreign body in Stensen's duct: a stone and broken wire basket
Clinical RecordSialendoscopy-assisted transfacial surgery for the removal of an iatrogenic foreign body in Stensen's duct: a stone and broken wire basketP Capaccioa1a2, M Gaffuria1a3 c1, S Torrettaa1a3 and L Pignataroa1a3 a1 Department of Otolaryngology and Head and Neck Surgery, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy a2 Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy a3 Department of Clinical Sciences and Community Health, University of Milan, Italy Abstract Background: A foreign body is a rare cause of parotid gland ...περισσότερα »
Early stage squamous cell carcinoma of the lower lip: predictive factors for recurrence
Main ArticleEarly stage squamous cell carcinoma of the lower lip: predictive factors for recurrenceY Ozkula1, M Songua1 c1, A Imrea1, E Tunca1, Z Ozkula2, S Arslanoglua1, E Pinara1 and K Onala1 a1 Department of Otorhinolaryngology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey a2 Department of Anaesthesia and Reanimation, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey Abstract Objective: This study aimed to evaluate the effect of tumour thickness on other clinicopathological parameters in early stage lower lip...περισσότερα »
Arachnoid cyst of the Fallopian canal and geniculate ganglion area: our experience of 9 cases
Arachnoid cyst of the Fallopian canal and geniculate ganglion area: our experience of 9 cases: Abstract Arachnoid cyst of the Fallopian canal should be suspected and sought in all cases of CSF leak or bacterial meningitis (especially *Streptococcus pneumonia, Haemophilus influenzae*) in overweight middle-aged women without any osteo-meningeal breach identified on the tegmen tympani. A combination of CT scan and MRI allows the diagnosis of arachnoid cyst of the Fallopian canal, can be used to rule out other confounding diagnoses and provides all essential pre-operative information. N... περισσότερα »
Serum 25-Hydroxyvitamin D Level Does Not Affect the Aggressiveness and Prognosis of Papillary Thyroid Cancer
Serum 25-Hydroxyvitamin D Level Does Not Affect the Aggressiveness and Prognosis of Papillary Thyroid Cancer: Thyroid , Vol. 0, No. 0. Author information Hwa Young Ahn,1 Yun Jae Chung,1 Kwang-Yeol Park,2 and Bo Youn Cho1 1Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea. 2Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea. Address correspondence to: *Yun Jae Chung, MD, PhD* *Department of Internal Medicine* *Chung-Ang University Hospital* *224-1 Heukseok-d... περισσότερα »
Sorafenib for the Treatment of Progressive Metastatic Medullary Thyroid Cancer: Efficacy and Safety Analysis
Sorafenib for the Treatment of Progressive Metastatic Medullary Thyroid Cancer: Efficacy and Safety Analysis: Thyroid , Vol. 0, No. 0. Author information Luciana Audi de Castroneves,1 Marcelo Vailati Negrão,2 Ricardo Miguel Costa de Freitas,3 Carla Papadia,1 José Viana Lima Jr.,4 Julia T. Fukushima,5 Eduardo Furquim Simão,6 Marco Aurélio Vamondes Kulcsar,7 Marcos Roberto Tavares,8 Alexander Augusto de Lima Jorge,9 Gilberto de Castro Jr.,2 Paulo Marcelo Hoff,2 and Ana Oliveira Hoff1 1Endocrinology Department; Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Univ...περισσότερα »
Serum 25-Hydroxyvitamin D Level Does Not Affect the Aggressiveness and Prognosis of Papillary Thyroid Cancer
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Serum 25-Hydroxyvitamin D Level Does Not Affect the Aggressiveness and Prognosis of Papillary Thyroid Cancer: Thyroid , Vol. 0, No. 0. Author information Hwa Young Ahn,1 Yun Jae Chung,1 Kwang-Yeol Park,2 and Bo Youn Cho1 1Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea. 2Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea. Address correspondence to: *Yun Jae Chung, MD, PhD* *Department of Internal Medicine* *Chung-Ang University Hospital* *224-1 Heukseok-d... περισσότερα »
Sorafenib for the Treatment of Progressive Metastatic Medullary Thyroid Cancer: Efficacy and Safety Analysis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Sorafenib for the Treatment of Progressive Metastatic Medullary Thyroid Cancer: Efficacy and Safety Analysis: Thyroid , Vol. 0, No. 0. Author information Luciana Audi de Castroneves,1 Marcelo Vailati Negrão,2 Ricardo Miguel Costa de Freitas,3 Carla Papadia,1 José Viana Lima Jr.,4 Julia T. Fukushima,5 Eduardo Furquim Simão,6 Marco Aurélio Vamondes Kulcsar,7 Marcos Roberto Tavares,8 Alexander Augusto de Lima Jorge,9 Gilberto de Castro Jr.,2 Paulo Marcelo Hoff,2 and Ana Oliveira Hoff1 1Endocrinology Department; Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Univ...περισσότερα »
Thyroid Imaging Reporting and Data System Risk Stratification of Thyroid Nodules: Categorization Based on Solidity and Echogenicity
Thyroid Imaging Reporting and Data System Risk Stratification of Thyroid Nodules: Categorization Based on Solidity and Echogenicity: Thyroid , Vol. 0, No. 0. Author information Dong Gyu Na,1 Jung Hwan Baek,2 Jin Yong Sung,3 Ji-Hoon Kim,4 Jae Kyun Kim,5 Young Jun Choi,2 andHyobin Seo6 1Department of Radiology, Human Medical Imaging and Intervention Center, Seoul, Korea. 2Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 3Departments of Radiology, Thyroid Center, Daerim St. Mary's Hospital, Seoul,...περισσότερα »
Confluent Fibrosis and Fibroblast Foci in Fibrotic Nonspecific Interstitial Pneumonia
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα
Abstract Background The separation of fibrotic NSIP (FNSIP) and usual interstitial pneumonia (UIP) is important to patient treatment and prognosis, but is sometimes a difficult diagnostic problem. Most authors believe that fibroblast foci are rare in NSIP and that the finding of multiple fibroblast foci suggests a diagnosis of UIP. Similarly, architectural distortion is viewed as favouring a diagnosis of UIP. Observations and measurements We report 8 patients with a high resolution CT diagnosis of FNSIP, and on biopsy a picture of fibrotic NSIP, but in all cases, fibrosis focally... περισσότερα »
Glucose Complexity Estimates Insulin Resistance in Either Non Diabetic Individuals or in Type 1 Diabetes.
*Glucose Complexity Estimates Insulin Resistance in Either Non Diabetic Individuals or in Type 1 Diabetes.* J Clin Endocrinol Metab. 2016 Feb 9;:jc20154035 Authors: Crenier L, Lytrivi M, Van Dalem A, Keymeulen B, Corvilain B Abstract CONTEXT: The clinical significance of glucose complexity is not fully understood. OBJECTIVE: We investigated the relationship between glucose complexity, glucose variability and insulin resistance. DESIGN AND SETTING: This was an observational study of 37 non-diabetic volunteers aged 12-65 years and 49 adults with longstanding type 1 diabetes (T1D) wh... περισσότερα »
Cord Blood Ferritin and Fibroblast Growth Factor-23 Levels in Neonates.
*Cord Blood Ferritin and Fibroblast Growth Factor-23 Levels in Neonates.* J Clin Endocrinol Metab. 2016 Feb 9;:jc20153709 Authors: Ali FN, Josefson J, Mendez AJ, Mestan K, Wolf M Abstract CONTEXT: Elevated levels of the phosphate-regulating hormone, fibroblast growth factor-23 (FGF23) are associated with skeletal and cardiovascular disease. Levels of FGF23 are elevated in neonates, but the mechanisms are poorly understood. Iron deficiency is a recently described stimulus for FGF23 production. OBJECTIVE: To test the hypothesis that lower fetal iron status, as measured by lower cord... περισσότερα »
Long-Term Insulin Independence in Type 1 Diabetes Mellitus Using a Simplified Autologous Stem Cell Transplant.
*Long-Term Insulin Independence in Type 1 Diabetes Mellitus Using a Simplified Autologous Stem Cell Transplant.* J Clin Endocrinol Metab. 2016 Feb 9;:jc20152776 Authors: Cantú-Rodríguez OG, Lavalle-González F, Herrera-Rojas MÁ, Jaime-Pérez JC, Hawing-Zárate JÁ, Homero Gutiérrez-Aguirre C, Mancias-Guerra C, González-Llano O, Zapata-Garrido A, Zacarias Villarreal-Pérez J, Gómez-Almaguer D Abstract CONTEXT: Efforts to find a cure for type 1 diabetes have focused on the removal of the autoimmune pathophysiologic substrate, with the use of immunosuppressive regimens including Autologo... περισσότερα »
Contemporary reproductive outcomes for patients with polycystic ovary syndrome: a retrospective observational study.
*Contemporary reproductive outcomes for patients with polycystic ovary syndrome: a retrospective observational study.* J Clin Endocrinol Metab. 2016 Feb 9;:jc20152682 Authors: Rees DA, Jenkins-Jones S, Morgan CL Abstract CONTEXT: Polycystic ovary syndrome (PCOS) is the commonest cause of anovulatory infertility and may be associated with adverse pregnancy and neonatal outcomes. However, it is difficult to establish how much of this risk is due to PCOS and how much to obesity. OBJECTIVE: To determine the impact of PCOS upon fertility, pregnancy and neonatal outcomes. DESIGN AND SET... περισσότερα »
Is violence in part a lithium deficiency state?
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Publication date: Available online 10 February 2016 *Source:*Medical Hypotheses Author(s): Mark R. Goldstein, Luca Mascitelli Violence, particularly firearm violence, leading to suicide and homicide is a significant problem worldwide. A majority of suicidal and homicidal violence involves males; homicidal violence is prevalent among young men and suicide is the leading cause of violence worldwide. Lithium, in pharmacological doses, has been used successfully for decades in treating bipolar disorders, and has been shown to decrease violent crime in this situation. Interestingly, lith... περισσότερα »
A hybrid fever therapy for increased tumor selectivity
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Publication date: Available online 10 February 2016 *Source:*Medical Hypotheses Author(s): Garry Noe Lipopolysaccharide (LPS), mediator of the Coley and Shwartzman fever therapies, is a potent endotoxin capable of inducing sepsis at moderate intravenous doses, which currently limits its experimental and clinical use. By exploiting elevated G-CSF concentrations and neutrophil numbers within tumors, it may be possible to selectively trigger a sepsis-like syndrome in malignant tissues using only moderate hyperthermia and low-dose LPS, leaving normal organs unaffected. Analogous to the ... περισσότερα »
Autologous Tumor Immunizing Devascularization in cancer therapy
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Publication date: Available online 10 February 2016 *Source:*Medical Hypotheses Author(s): Vladimir Kalina, David J. Kopsky Tumor vaccination depending on specific antigens, autologous tumor vaccination involving wide range of antigens, immunomodulating cytokines and bacterial agents have been studied extensively with the purpose of stimulating the antitumor immune response. Unfortunately these therapies showed disappointing results mainly due to undesirable mechanisms tending to dampen the antitumor immune response. We will discuss a novel approach of autologous tumor immunization ... περισσότερα »
Salt and miscarriage: is there a link?
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Publication date: Available online 9 February 2016 *Source:*Medical Hypotheses Author(s): Amir Abdoli Salt is a major mineral element that plays fundamental roles in health and disease. Excessive salt intake is a major cause of hypertension, cardiovascular disease and stroke. Miscarriage and preeclampsia are the most common pregnancy complications with multiple etiological factors, including inflammatory and autoimmune conditions. More recently, different studies indicated that excessive salt intake is involved in the development of inflammatory processes through induction of T help...περισσότερα »
Proteome analysis of Bordetella pertussis isolated from human macrophages
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Publication date: Available online 10 February 2016 *Source:*Journal of Proteomics Author(s): Yanina Lamberti, Juan Hilario Cafiero, Kristin Surmann, Hugo Valdez, Jana Holubova, Večerek Branislav, Peter Sebo, Frank Schmidt, Uwe Völker, Maria Eugenia Rodriguez Graphical abstract [image: image] from #Medicine via ola Kala on Inoreader http://ift.tt/1PkGlUE via IFTTT
Catalysts, Vol. 6, Pages 27: Highly Efficient Cationic Palladium Catalyzed Acetylation of Alcohols and Carbohydrate-Derived Polyols
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
The development of a new facile method for the acetylation of alcohols and carbohydrate-derived polyols is described. This method relies on the nature of the cationic palladium catalyst, Pd(PhCN)2(OTf)2 which is generated in situ from Pd(PhCN)2Cl2 and AgOTf to catalyze the acetylation reaction. This new acetylation protocol is very rapid and proceeds under mild conditions with only 1 mol% of catalyst loading at room temperature. This new method has been applied to a variety of different alcohols with different levels of steric hindrance, as well as carbohydrate-derived polyols to p...περισσότερα »
Polymers, Vol. 8, Pages 47: Developed Hybrid Model for Propylene Polymerisation at Optimum Reaction Conditions
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
A statistical model combined with CFD (computational fluid dynamic) method was used to explain the detailed phenomena of the process parameters, and a series of experiments were carried out for propylene polymerisation by varying the feed gas composition, reaction initiation temperature, and system pressure, in a fluidised bed catalytic reactor. The propylene polymerisation rate per pass was considered the response to the analysis. Response surface methodology (RSM), with a full factorial central composite experimental design, was applied to develop the model. In this study, analy... περισσότερα »
Protective Role of Sodium–Glucose Co-Transporter 2 Inhibition Against Vascular Complications in Diabetes
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Rejuvenation Research , Vol. 0, No. 0. from #Medicine via ola Kala on Inoreader http://ift.tt/1Q8CGwY via IFTTT
Predictors of Virological Response in 3,235 Chronic HCV Egyptian Patients Treated with Peginterferon Alpha-2a Compared with Peginterferon Alpha-2b Using Statistical Methods and Data Mining Techniques
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Journal of Interferon & Cytokine Research , Vol. 0, No. 0. from #Medicine via ola Kala on Inoreader http://ift.tt/1T6Viwb via IFTTT
Operational method of solution of linear non-integer ordinary and partial differential equations
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
We propose operational method with recourse to generalized forms of orthogonal polynomials for solution of a variety of differential equations of mathematical physics. Operational definitions of generalized families of orthogonal polynomials are used in this context. Integral transforms and the operational exponent together with some special functions are also employed in the solutions. The examples of solution of physical problems, related to such problems as the heat propagation in various models, evolutional processes, Black–Scholes-like equations etc. are demonstrated by the o... περισσότερα »
Evaluation of wild herbivore faeces from South Africa as a potential source of hydrolytically active microorganisms
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
This study assessed faecal matter from three indigenous South African herbivores—zebra, giraffe and impala—as a potential source for hydrolytically active aerobic and facultatively anaerobic bacteria. Herbivore droppings were collected freshly in a local nature reserve in Pietermaritzburg, South Africa. Soil samples adjacent to faecal collection sites and faeces from a domestic herbivore, the Nguni cow, were included as controls. Hydrolase and dehydrogenase activity in faecal matter and soil samples were measured by the fluorescein diacetate and the triphenyltetrazolium chloride a... περισσότερα »
Integrated measures for rough sets based on general binary relations
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Uncertainty measures are important for knowledge discovery and data mining. Rough set theory (RST) is an important tool for measuring and processing uncertain information. Although many RST-based methods for measuring system uncertainty have been investigated, the existing measures cannot adequately characterise the imprecision of a rough set. Moreover, these methods are suitable only for complete information systems, and it is difficult to generalise methods for complete information systems to incomplete information systems. To overcome these shortcomings, we present new uncertai...περισσότερα »
Issue Information - TOC
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
No abstract is available for this article. from #Medicine via ola Kala on Inoreader http://ift.tt/1QV89zE via IFTTT
Issue Information - JIF
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
No abstract is available for this article. from #Medicine via ola Kala on Inoreader http://ift.tt/1KEYHB6 via IFTTT
Comment on “Ventricular non-compaction cardiomyopathy: prenatal diagnosis and pathology”
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
from #Medicine via ola Kala on Inoreader http://ift.tt/1QV89ja via IFTTT
Increased nuchal translucency and pregnancy outcome: a retrospective study of 1063 consecutive singleton pregnancies in a single referral institution
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
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Metabolic effect of pancreatoduodenectomy: Resolution of diabetes mellitus after surgery
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Pancreatology from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUeGk via IFTTT
Evaluation of advanced fibrosis measured by transient elastography after hepatitis C virus protease inhibitor-based triple therapy
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
European Journal of Gastroenterology & Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUeGe via IFTTT
Prevention of necrotizing enterocolitis through manipulation of the intestinal microbiota of the premature infant
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Clinical Therapeutics from #Medicine via ola Kala on Inoreader http://ift.tt/20KSPxp via IFTTT
A randomized, double-blind, placebo-controlled phase II study to assess the efficacy and safety of mapatumumab with sorafenib in patients with advanced hepatocellular carcinoma
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Annals of Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQRW via IFTTT
MiR-143 inhibits tumor cell proliferation and invasion by targeting STAT3 in esophageal squamous cell carcinoma
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Cancer Letters from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUbKB via IFTTT
Levofloxacin, bismuth, amoxicillin and esomeprazole as second-line Helicobacter pylori therapy after failure of non-bismuth quadruple therapy
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Digestive and Liver Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUepH via IFTTT
Antibacterial gauzes are effective in preventing infections after percutaneous endoscopic gastrostomy placement: a retrospective analysis
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
European Journal of Gastroenterology & Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQBC via IFTTT
Hepatocellular carcinoma in children: does modified platinum- and doxorubicin-based chemotherapy increase tumor resectability and change outcome? lessons learned from the SIOPEL 2 and 3 studies
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Journal of Clinical Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUepz via IFTTT
The variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQlc via IFTTT
Issue Information
from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Lgm7aU via IFTTT
Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non-invasive imaging
Abstract Background Current investigations of stomach function are based on small test meals that do not reliably induce symptoms and analysis techniques that rarely detect clinically relevant dysfunction. This study introduces the large ‘Nottingham Test Meal’ (NTM) for assessment of gastric motor and sensory function by non-invasive imaging. Methods NTM comprises 400 mL liquid nutrient (0.75 kcal/mL) and 12 solid agar-beads (0 kcal) with known breaking strength. Gastric fullness and dyspeptic sensations were documented by 100 mm visual analogue scale (VAS). Gastric emptying (GE) w...περισσότερα »
Pierre Robin Sequence With Full Stomach for Emergency Ventriculoperitoneal Shunt: Anesthetic Challenges.
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1o24u9T via IFTTT
Journal Club.
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1o24tTF via IFTTT
Effects of an Intraoperative Dexmedetomidine Bolus on the Postoperative Blood Pressure and Pain Subsequent to Craniotomy for Supratentorial Tumors.
Background: Control of emergence hypertension and pain is important after craniotomy for monitoring the neurological status. This prospective double-blinded study investigated the hemodynamics after a single bolus of dexmedetomidine (DEX) infusion administered to the patient undergoing craniotomy under general anesthesia, and its effect on emergence hypertension and postsurgical pain. Methods: Adult patients scheduled for elective surgery for supratentorial tumors were randomized to receive a 10-minute intraoperative DEX infusion of 0.4 [mu]g/kg (small dose, n=43) or 0.8 [mu]g/kg (m...περισσότερα »
Differences in hospital attendance for anaphylaxis between immigrants and non-immigrants: a cohort study
Abstract Background The impact of migration on the risk of anaphylaxis is unknown. We hypothesized that non-Western immigrants have a lower incidence of anaphylaxis compared to Danish-born. We investigated variations in hospital attendance for anaphylaxis between immigrants and Danish-born including time- and age- trends. Methods A register-based, historical prospective cohort design. Refugees or family reunified immigrants (n=127,250) who, between January 1,1994 and December 31, 2010, obtained residency permits in Denmark were included and matched in a 1:6 ratio on age and sex wit...περισσότερα »
Ε.Σ.Α.μεΑ.: Έκκληση προς τα αγροτικά μπλόκα
*ΔΕΛΤΙΟ ΤΥΠΟΥ* *Ε.Σ.Α.μεΑ.: Έκκληση προς τα αγροτικά μπλόκα* Αθήνα: 08.02.2016 Αρ. Πρωτ.:161 Η Εθνική Συνομοσπονδία Ατόμων με Αναπηρία (Ε.Σ.Α.μεΑ.), όπως είναι γνωστό σε όλη την κοινωνία, στηρίζει τις δίκαιες αιτήσεις όλων των κοινωνικών ομάδων στον αγώνα ενάντια στο ασφαλιστικό νομοσχέδιο. Στηρίζει και συμπαρίσταται και στα αιτήματα του αγροτικού κόσμου και στις κινητοποιήσεις του. Με αίσθημα αλληλεγγύης απευθύνεται στον αγροτικό κόσμο που αγωνίζεται και κάνει έκκληση να δείξει την ίδια κοινωνική ευαισθησία προς τα άτομα με αναπηρία, χρόνιες παθήσεις και τις οικογένειές τους, ... περισσότερα »
Hyperpigmented Plaques of the Alar Crease: An Unusual Presentation of Acanthosis Nigricans
Abstract Although acanthosis nigricans of the posterior neck and intertriginous areas is common, acanthosis nigricans of the supra-alar creases is rare. We present the case of an obese 16-year-old African American boy with hyperpigmented plaques along the supra-alar creases of his nose. Clinicians should be aware of this rare manifestation, because newly diagnosed acanthosis nigricans should prompt examination for insulin resistance. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1PkoLQW via IFTTT
Water-Holding and Transport Properties of Skin Stratum Corneum of Infants and Toddlers Are Different from Those of Adults: Studies in Three Geographical Regions and Four Ethnic Groups
Abstract Background/Objective Epidermal structure, function, and composition are different in white infants and adults. We investigated whether ethnicity and location contribute to differences in functional and clinical measurements of skin barrier function during the first years of life and in adults. Methods Children (*n* = 397, ages 3–49 mos) and women (*n* = 117, mean age 31 yrs) were enrolled at independent centers in Beijing, China (ethnic Chinese), Skillman, New Jersey (white, African American), and Mumbai, India (ethnic South Asian). Water barrier properties of the stratum c... περισσότερα »
Radiologic Improvement After Early Medical Intervention in Localised Facial Morphea
Abstract We report the case of a young girl who presented with hemiparesis, seizures, and subtle features consistent with a linear form of facial morphea (en coup de sabre). She was treated with pulsed parenteral steroids and oral steroids and started on methotrexate. Magnetic resonance imaging results and neurologic problems improved after 6 months. Switching off inflammation early in the course of disease seemed to reverse some of the central nervous system changes. Assessment of children with unexplained hemiparesis and seizures should include careful examination of the face and ...περισσότερα »
Palisaded Neutrophilic Granulomatous Dermatitis in a Child with Juvenile Idiopathic Arthritis on Etanercept
Abstract Palisaded neutrophilic granulomatous dermatitis (PNGD) is a rare neutrophilic dermatosis that may be associated with significant morbidity because of associated pruritus and pain. It is typically seen in adults with collagen vascular diseases, but may be associated with medications as well. PNGD is rarely reported in children. We describe a girl with polyarticular juvenile idiopathic arthritis who developed PNGD after administration of etanercept and demonstrated rapid and significant improvement upon treatment with topical triamcinolone 0.1% ointment. from #ORL-Sfakianak... περισσότερα »
Serum Vitamin D Levels Not Associated with Atopic Dermatitis Severity
Abstract Backgound/objectives The objective of the current study was to determine the relationship between serum vitamin D levels and the severity of atopic dermatitis (AD) in a Brazilian population. Methods This was a cross-sectional study of patients younger than 14 years of age seen from April to November 2013. All patients fulfilled the Hanifin and Rajka Diagnostic Criteria for AD diagnosis. Disease severity was determined using the SCORing Atopic Dermatitis index and classified as mild (<25), moderate (25–50), or severe (>50). Serum vitamin D levels were classified as sufficie...περισσότερα »
Neurovascular Stains in Two Girls with Neurofibromatosis 1
Abstract We report two girls, ages 9 and 17 years, with a clinical diagnosis of neurofibromatosis 1 (NF-1) who presented with ill-defined, blanchable, erythematous patches on the dorsal feet and ankles. We hypothesized that these patches were a rare cutaneous finding in NF-1 that exist on a clinical and histopathologic spectrum with previously described NF-1 vascular lesions including blue–red macules and skin ulceration due to NF-1 vasculopathy. We suggest that these lesions be called neurovascular stains (NVSs) to unify their clinical and histopathologic features. from #ORL-Sfak... περισσότερα »
High-Potency Topical Steroids: An Effective Therapy for Chronic Scalp Inflammation in Rapp–Hodgkin Ectodermal Dysplasia
Abstract Chronic erosive pustular dermatitis with a predilection for the scalp is a hallmark of ectodermal dysplasias (EDs) caused by mutations in *TP**63*, including Rapp–Hodgkin and Hay–Wells EDs. It is among the most troublesome and symptomatic complications and is typically refractory to classic wound care approaches. We report two cases of Rapp–Hodgkin ED with refractory scalp erosions that markedly improved with the use of potent topical steroids. We also note marked similarities between this scalp inflammation and “erosive pustular dermatosis of the scalp,” a condition more t...περισσότερα »
The Effects of the Toll-Like Receptor 4 Antagonist, Ibudilast, on Sevoflurane's Minimum Alveolar Concentration and the Delayed Remifentanil-Induced Increase in the Minimum Alveolar Concentration in Rats.
BACKGROUND: Ultralow doses of naloxone, an opioid and toll-like receptor 4 antagonist, blocked remifentanil-induced hyperalgesia and the associated increase in the minimum alveolar concentration (MAC), but not tolerance. The aim was to determine the effects of the toll-like receptor 4 antagonist, ibudilast, on the MAC in the rat and how it might prevent the effects of remifentanil. METHODS: Male Wistar rats were randomly allocated to 5 treatment groups (n = 7 per group): 10 mg/kg ibudilast intraperitoneally, 240 [micro]g/kg/h remifentanil IV, ibudilast plus remifentanil, remifentani... περισσότερα »
Emulsified Isoflurane Protects Against Transient Focal Cerebral Ischemia Injury in Rats via the PI3K/Akt Signaling Pathway.
BACKGROUND: Phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt) pathway activation may promote neuronal survival via neuroprotection during inflammation after cerebral ischemia. In this study, we investigated whether IV pretreatment with emulsified isoflurane (EI) could decrease ischemic brain injury related to the PI3K/Akt pathway. METHODS: Male Sprague-Dawley rats received different doses of IV EI (1, 2, 4, or 8 mL/kg/h) or Intralipid(R) (8 mL/kg/h) for 30 minutes (n = 6-12 per group), followed by middle cerebral artery occlusion (MCAO) for 100 minutes to induce transient foca... περισσότερα »
The Importance of the Saphenous Nerve in Ankle Surgery.
BACKGROUND: Recent evidence suggests that the saphenous nerve may be involved in the innervation of deeper structures at the medial ankle. In this study, we sought to determine the consistency and variability of the saphenous nerve innervation at the distal tibia and medial ankle joint capsule. METHODS: One hundred three lower extremities from 52 embalmed cadavers were dissected to identify the deep branches of saphenous nerve along its distal course. RESULTS: In all specimens, the saphenous nerve had branches, emerging between 3.9 and 8.2 cm above the medial malleolus, to the perio... περισσότερα »
Amnesia of the Operating Room in the B-Unaware and BAG-RECALL Clinical Trials.
BACKGROUND: Patient memories of the operating room (OR) may serve as the informational basis for assessing satisfaction with individual anesthesiologists. Furthermore, the provision of clinically important information may assume that perioperative memories are retained. Studies assessing the extent of perioperative amnesia and factors associated with perioperative amnesia are sparse. Therefore, we assessed patient amnesia of the OR and of the preoperative holding area in hospitals where midazolam is typically administered in the preoperative holding area and evaluated whether midazo...περισσότερα »
Abstract not submitted for publication
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Abstract not submitted for publication
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Abstract not submitted for publication
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PNnuTN via IFTTT
Abstract not presented and not submitted for publication
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1WdZBVS via IFTTT
Abstract not presented and not submitted for publication
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PNnvXU via IFTTT
Spatial analysis of condyle position according to sagittal skeletal relationship, assessed by cone beam computed tomography
The study aims to compare the condylar position in patients with different anteroposterior sagittal skeletal relationships through a cone beam computed generated tomography (CBCT) imaging generated space analy... from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1T6Vhsa via IFTTT
Perceptions of dental professionals and laypeople to altered dental esthetics in cases with congenitally missing maxillary lateral incisors
The smile perception of patients is not strictly related to standardized protocols and technical implications which certainly affect clinicians' decisions. The absence of maxillary lateral incisors could affec... from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1T6Vhs2 via IFTTT
An easy method of attachment to an impacted canine
Since many years, various bonding attachments have been used as a mode of traction for surgically exposed impacted teeth. It has always been a challenge to select an attachment considering predictability of th... from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1Xi5thW via IFTTT
Occlus-o-Guide® versus Andresen activator appliance: neuromuscular evaluation
The aim of the present study was to assess the muscular variations at the electromyography (EMG) level for the anterior temporalis muscles and masseter muscles during treatment with Occlus-o-Guide® and Andresen a... from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1T6VdZA via IFTTT
Experimental models for contamination of titanium surfaces and disinfection protocols
[image: cover.gif?v=1&s=be74442fea687c39b7fdfa63] Abstract Aim The aim of this pilot study was to describe an *in vitro* model of peri-implantitis microcosm for contamination of titanium surfaces and an *in vivo* model for evaluating different disinfection strategies of titanium surfaces. Materials and methods Biofilms were grown *in vitro* for 30 days on sandblasted large-grit acid-etched (SLA) Ti discs (*n* *=* 69) in a constant depth film fermentor (CDFF) associated with peri-implantitis conditions. Four Swedish loop rabbits were randomly allocated in three test groups (T1, ... περισσότερα »
Protective Role of Sodium–Glucose Co-Transporter 2 Inhibition Against Vascular Complications in Diabetes
Rejuvenation Research , Vol. 0, No. 0. from #Medicine via ola Kala on Inoreader http://ift.tt/1Q8CGwY via IFTTT
Predictors of Virological Response in 3,235 Chronic HCV Egyptian Patients Treated with Peginterferon Alpha-2a Compared with Peginterferon Alpha-2b Using Statistical Methods and Data Mining Techniques
Journal of Interferon & Cytokine Research , Vol. 0, No. 0. from #Medicine via ola Kala on Inoreader http://ift.tt/1T6Viwb via IFTTT
Operational method of solution of linear non-integer ordinary and partial differential equations
We propose operational method with recourse to generalized forms of orthogonal polynomials for solution of a variety of differential equations of mathematical physics. Operational definitions of generalized families of orthogonal polynomials are used in this context. Integral transforms and the operational exponent together with some special functions are also employed in the solutions. The examples of solution of physical problems, related to such problems as the heat propagation in various models, evolutional processes, Black–Scholes-like equations etc. are demonstrated by the o... περισσότερα »
Evaluation of wild herbivore faeces from South Africa as a potential source of hydrolytically active microorganisms
This study assessed faecal matter from three indigenous South African herbivores—zebra, giraffe and impala—as a potential source for hydrolytically active aerobic and facultatively anaerobic bacteria. Herbivore droppings were collected freshly in a local nature reserve in Pietermaritzburg, South Africa. Soil samples adjacent to faecal collection sites and faeces from a domestic herbivore, the Nguni cow, were included as controls. Hydrolase and dehydrogenase activity in faecal matter and soil samples were measured by the fluorescein diacetate and the triphenyltetrazolium chloride a... περισσότερα »
Integrated measures for rough sets based on general binary relations
Uncertainty measures are important for knowledge discovery and data mining. Rough set theory (RST) is an important tool for measuring and processing uncertain information. Although many RST-based methods for measuring system uncertainty have been investigated, the existing measures cannot adequately characterise the imprecision of a rough set. Moreover, these methods are suitable only for complete information systems, and it is difficult to generalise methods for complete information systems to incomplete information systems. To overcome these shortcomings, we present new uncertai...περισσότερα »
Exosomes: potential for early detection in pancreatic cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1KbthSI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Older and younger adults surf different brain waves: Scientists discover how aging rewires our brain
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Cognitive scientists have found more evidence that aging brains work differently than younger brains when performing the same memory task, pointing to a potentially new direction for age-related… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1o2dnQN via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The effect of nebulized albuterol on serum lactate and potassium in healthy subjects
Academic Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QVbXko via IFTTT
Pathologic fracture a poor prognostic factor in osteosarcoma: Misleading conclusions from meta-analyses?
European Journal of Surgical Oncology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RoUyCD via IFTTT
Predicting the occurrence of hypotension in stable patients with nonvariceal upper gastrointestinal bleeding: point-of-care lactate testing
The Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QVbYVk via IFTTT
Thyroid Imaging Reporting and Data System Risk Stratification of Thyroid Nodules: Categorization Based on Solidity and Echogenicity
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1KbtjKz via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Sorafenib for the Treatment of Progressive Metastatic Medullary Thyroid Cancer: Efficacy and Safety Analysis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1V39Goi via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Serum 25-Hydroxyvitamin D Level Does Not Affect the Aggressiveness and Prognosis of Papillary Thyroid Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1KbtjKp via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Exosomes: potential for early detection in pancreatic cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1KbthSI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Zwischen positiver Herzaktion und Ersttrimesterscreening
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Pränatale Ultraschalldiagnostik Sonographische Bildgebung im ersten Drittel der Schwangerschaft zielt mitnichten ausschließlich auf die Ergebnisse des Ersttrimesterscreenings ab. Ein ausführlicher Überblick über Möglichkeiten und Grenzen der Sonoembryologie from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Kbr89O via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Learning disorders: Know the signs, how to help
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Udg6Bb via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Multikinase inhibitor regorafenib inhibits the growth and metastasis of colon cancer with abundant stroma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Interaction between tumor cells and stromal cells plays an important role in the growth and metastasis of colon cancer. We previously found that carcinoma-associated fibroblasts (CAFs) expressed platelet-derived growth factor receptor-beta (PDGFR-β) and that PDGFR targeted therapy by using imatinib or nilotinib inhibited stromal reaction. Bone marrow-derived mesenchymal stem cells (MSCs) migrate to tumor […]
Arachnoid cyst of the Fallopian canal and geniculate ganglion area: our experience of 9 cases
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Arachnoid cyst of the Fallopian canal should be suspected and sought in all cases of CSF leak or bacterial meningitis (especially Streptococcus pneumonia, Haemophilus influenzae) in overweight middle-aged women without any osteo-meningeal breach identified on the tegmen tympani. A combination of CT scan and MRI allows the diagnosis of arachnoid cyst of the Fallopian […]
Parkinson’s patients trained to respond to placebos
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Study suggests how dummy pills might reduce drug doses in routine care. Nature News doi: 10.1038/nature.2016.19341 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TRNGym via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The involvement of mutant Rac1 in the formation of invadopodia in cultured melanoma cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 10 February 2016 Source:Experimental Cell Research Author(s): Or-Yam Revach, Sabina E. Winograd-Katz, Yardena Samuels, Benjamin Geiger In this article we discuss the complex involvement of Rho-family GTPase, Rac1, in cell migration and in invadopodia-mediated matrix degradation. We discuss the involvement of invadopodia in invasive cell migration, and their capacity to promote […]
Horizontal mucosal thickness at implant sites as it correlates with the integrity and thickness of the buccal bone plate
[image: cover.gif?v=1&s=be74442fea687c39b7fdfa63] Abstract Objectives To histologically assess the association between the horizontal mucosal thickness (MT) at implant sites with the integrity and thickness of the buccal bone plate in a canine model. Materials and methods Two-piece titanium implants were placed at chronic-type lateral ridge defects. The resulting vestibular dehiscence-type defects (vertical dimensions of 2–8 mm) were left untreated. After a submerged healing period of 2 and 8 weeks (*n* = 6 fox hounds each), dissected blocks were processed for histomorphometric... περισσότερα »
An in vitro study on disinfection of titanium surfaces
Abstract Objective The aim of this *in vitro* study was to evaluate the efficacy of different methods used for the decontamination of titanium surfaces previously infected with a *Staphylococcus aureus* biofilm. Materials and Methods *S. aureus* biofilms were grown on three different titanium surfaces (*n = *114); polished, sandblasted large-grit acid-etched (SLA) and SLActive. The experimental groups were divided into six different disinfection modalities as follows: (i) rinsing with phosphate-buffered saline, (ii) rinsing with chlorhexidine digluconate 0.2% (CHX), (iii) applica... περισσότερα »
A diversity of peri-implant mucosal thickness by site
[image: cover.gif?v=1&s=be74442fea687c39b7fdfa63] Abstract Objectives The objective of this study was to examine peri-implant mucosal thickness at different sites of peri-implant crevice around 70 implants placed in 35 patients. Material and methods The peri-implant mucosal thickness was defined as distance of the peri-implant mucosal margin and the coronal edge of bone/implant contact and measured using the cast models and dental radiography. Results The overall mean peri-implant mucosal thickness was 3.6 ± 1.4 mm, wherein maxillary anterior implants, maxillary posterior impl...περισσότερα »
Antibacterial gauzes are effective in preventing infections after percutaneous endoscopic gastrostomy placement: a retrospective analysis
European Journal of Gastroenterology & Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQBC Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Hepatocellular carcinoma in children: does modified platinum- and doxorubicin-based chemotherapy increase tumor resectability and change outcome? lessons learned from the SIOPEL 2 and 3 studies
Journal of Clinical Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUepz Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent
Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQlc Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Multiple HBV quasispecies and immune-escape mutations are present in HBV surface antigen and reverse transcriptase of patients with acute hepatitis B
The Journal of Infectious Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUe9h Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The clinical management of abdominal ascites, spontaneous bacterial peritonitis and hepatorenal syndrome: a review of current guidelines and recommendations
European Journal of Gastroenterology & Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQl1 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
CA19-9 decrease at 8 weeks as a predictor of overall survival in a randomized phase III trial (MPACT) of weekly nab-paclitaxel plus gemcitabine vs gemcitabine alone in patients with metastatic pancreatic cancer
Annals of Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUe99 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Impact of smoking cessation on the clinical course of Crohn’s disease under current therapeutic algorithms: A multicenter prospective study
The American Journal of Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSOK5 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Clinical and immunologic features of ultra-short celiac disease
Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUbdF Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Predicting the Occurrence of Hypotension in Stable Patients With Nonvariceal Upper Gastrointestinal Bleeding: Point-of-Care Lactate Testing
The Journal of Emergency Medicine from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQ4r Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Randomized controlled trial of intraportal chemotherapy combined with adjuvant chemotherapy (mFOLFOX6) for stage II and III colon cancer
Annals of Surgery from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUbdD Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
upper respiratory tract infection; +39 new citations
39 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/02/10 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1V3bT2Z via IFTTT
IL-33 Mediates reactive eosinophilopoiesis in response to airborne allergen exposure
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Exposure to aeroallergens induces eosinophilic airway inflammation in patients with asthma and allergic airway diseases. The circulating number of eosinophils in peripheral blood is relatively small, leading us to hypothesize that bone marrow needs to be engaged quickly to meet the demands of the tissues. Methods To investigate the communication between the lungs […]
A randomized, 5-arm dose finding study with a mite allergoϊd SCIT in allergic rhinoconjunctivitis patients
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background The safety and tolerability of a mite allergoϊd subcutaneous allergen immunotherapy (SCIT) product was previously established. The aim of this study was to find the optimally safe and effective allergoϊd dose by evaluating several dosages in patients with house dust mites (HDM)-induced allergic rhinoconjunctivitis (ARC) using a titrated nasal provocation test (TNPT). Methods […]
Developmental programming, a pathway to disease
Endocrinology, Early Release. from Endocrinology via ola Kala on Inoreader http://ift.tt/1Pkmjdd via IFTTT
Exosomes: potential for early detection in pancreatic cancer
Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/1Q8vJMm via IFTTT
Gender Difference in the Epidemiological Association between Metabolic Syndrome and Olfactory Dysfunction: The Korea National Health and Nutrition Examination Survey.
*Gender Difference in the Epidemiological Association between Metabolic Syndrome and Olfactory Dysfunction: The Korea National Health and Nutrition Examination Survey.* PLoS One. 2016;11(2):e0148813 Authors: Hwang SH, Kang JM, Seo JH, Han KD, Joo YH Abstract Metabolic syndrome (MetS) is associated with a higher risk of morbidity and/or mortality for various chronic diseases. The aim of this study was to investigate the relationships of MetS and its components with olfactory dysfunction in a representative Korean population. We analyzed the data from the Korean National Health and...περισσότερα »
Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus.
*Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus.* Oncotarget. 2016 Feb 7; Authors: Lim SM, Park HS, Kim S, Kim S, Ali SM, Greenbowe JR, Yang IS, Kwon NJ, Lee JL, Ryu MH, Ahn JH, Lee J, Lee MG, Kim HS, Kim H, Kim HR, Moon YW, Chung HC, Kim JH, Kang YK, Cho BC Abstract BACKGROUND: Given the modest responses to everolimus, a mTOR inhibitor, in multiple tumor types, there is a pressing need to identify predictive biomarkers for this drug. Using targeted ultra-deep sequencing, we aimed to explore genomic alterations that confer extr... περισσότερα »
Prevalence of Pulsatile Tinnitus Among Patients With Migraine.
*Prevalence of Pulsatile Tinnitus Among Patients With Migraine.* Otol Neurotol. 2016 Feb 6; Authors: Weinreich HM, Carey JP Abstract OBJECTIVE: To examine the prevalence of pulsatile tinnitus (PT) among patients with a diagnosis of migraine and to determine if treatment of migraine improves symptoms. STUDY DESIGN: Single-institution retrospective patient review. SETTING: Academic tertiary referral center. PATIENTS: Billing data capturing ICD-9 codes 346.xx and 388.3x was used to identify patients with history of migraine and tinnitus. Patients were excluded if the symptom of PT cou...περισσότερα »
Intratympanic Iodine Contrast Injection Diffuses Across the Round Window Membrane Allowing for Perilymphatic CT Volume Acquisition Imaging.
*Intratympanic Iodine Contrast Injection Diffuses Across the Round Window Membrane Allowing for Perilymphatic CT Volume Acquisition Imaging.* Otol Neurotol. 2016 Feb 6; Authors: Abt NB, Lehar M, Guajardo CT, Penninger RT, Ward BK, Pearl MS, Carey JP Abstract HYPOTHESIS: Whether the round window membrane (RWM) is permeable to iodine-based contrast agents (IBCA) is unknown; therefore, our goal was to determine if IBCAs could diffuse through the RWM using CT volume acquisition imaging. INTRODUCTION: Imaging of hydrops in the living human ear has attracted recent interest. Intratympa... περισσότερα »
Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea.
*Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea.* PLoS One. 2016;11(2):e0148339 Authors: Geng R, Noda T, Mulvaney JF, Lin VY, Edge AS, Dabdoub A Abstract BACKGROUND: In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, and homeostasis of the stria vascularis. In neonatal tissue Wnt signaling can drive proliferation of cells in the sensory region, suggesting that Wn...περισσότερα »
Objective and Subjective Outcome of a New Transcutaneous Bone Conduction Hearing Device: Half-year Follow-up of the First 12 Nordic Implantations.
*Objective and Subjective Outcome of a New Transcutaneous Bone Conduction Hearing Device: Half-year Follow-up of the First 12 Nordic Implantations.* Otol Neurotol. 2016 Mar;37(3):267-275 Authors: Eberhard KE, Olsen SØ, Miyazaki H, Bille M, Caye-Thomasen P Abstract OBJECTIVE: To examine the objective and subjective outcome of a new transcutaneous bone conduction hearing device. STUDY DESIGN: Prospective, consecutive case series. PATIENTS: Twelve patients were implanted. Eight patients had a conductive/mixed (con/mix) hearing loss. Four had single sided deafness. MAIN OUTCOME MEASURES... περισσότερα »
Therapeutic Effect of Histone Deacetylase Inhibitor, Sodium Butyrate, on Allergic Rhinitis In Vivo.
*Therapeutic Effect of Histone Deacetylase Inhibitor, Sodium Butyrate, on Allergic Rhinitis In Vivo.* DNA Cell Biol. 2016 Feb 9; Authors: Wang J, Wen L, Wang Y, Chen F Abstract Despite the well-documented therapeutic effects of histone deacetylase inhibitor (HDACi) on various diseases, including arthritis and asthma, the therapeutic effect of HDACi on allergic rhinitis remains unmentioned in the literature. This study investigated the therapeutic effect of sodium butyrate (SoB), a form of HDACi, on mice with allergic rhinitis. The results showed that the expression levels of hist... περισσότερα »
Vocal Fold Augmentation with Beta Glucan Hydrogel Cross-Linked by γ Irradiation for Enhanced Duration of Effect: In Vivo Animal Study.
*Vocal Fold Augmentation with Beta Glucan Hydrogel Cross-Linked by γ Irradiation for Enhanced Duration of Effect: In Vivo Animal Study.* Biomed Res Int. 2015;2015:592372 Authors: Lim YM, Kim BH, Kim HB, Park E, Park SW, Park JS, Choi SI, Kwon TK, Kwon SK Abstract This study explored a novel strategy to restore the vocal gap by using cross-linked β-glucan hydrogel by γ-irradiation. An aqueous solution of 5 wt% β-glucan was prepared and cross-linked using (60)Co γ irradiation. Ten nude mice were injected with 0.8 mL of irradiated β-glucan on the left back and the same volume of non...περισσότερα »
A Case of Metastatic Head and Neck Squamous Cell Carcinoma with Multiple Treatments Including Stereotactic Ablative Body Radiotherapy Alone for Oligometastases to the Parotid Gland.
*A Case of Metastatic Head and Neck Squamous Cell Carcinoma with Multiple Treatments Including Stereotactic Ablative Body Radiotherapy Alone for Oligometastases to the Parotid Gland.* Cureus. 2015;7(12):e438 Authors: Sharrett J, Pederson A Abstract Head and neck squamous cell carcinoma (HNSCC) has a reported average of around 15% metastases at presentation with chemotherapy being the mainstay of treatment for widely metastatic disease. However, in select patients with oligometastatic disease, local ablative therapy (commonly including surgery or radiotherapy) can be utilized with... περισσότερα »
Castleman Disease of the Parotid Gland: A Report of a Case.
*Castleman Disease of the Parotid Gland: A Report of a Case.* Case Rep Otolaryngol. 2015;2015:265187 Authors: Abo-Alhassan F, Faras F, Bastaki J, Al-Sihan MK Abstract Castleman disease is an extremely rare benign lymphoproliferative disorder of unknown etiology. It affects the lymphatic chain in anybody region, although the commonest site is the mediastinum. The head and neck region is the second most common site; however, the salivary glands are rarely affected. We report a case of a 29-year-old Asian lady who presented with a 2-year history of an enlarging left parotid mass. His...περισσότερα »
Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo.
*Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo.* Proc Natl Acad Sci U S A. 2016 Feb 8; Authors: Simonetti FR, Sobolewski MD, Fyne E, Shao W, Spindler J, Hattori J, Anderson EM, Watters SA, Hill S, Wu X, Wells D, Su L, Luke BT, Halvas EK, Besson G, Penrose KJ, Yang Z, Kwan RW, Van Waes C, Uldrick T, Citrin DE, Kovacs J, Polis MA, Rehm CA, Gorelick R, Piatak M, Keele BF, Kearney MF, Coffin JM, Hughes SH, Mellors JW, Maldarelli F Abstract Reservoirs of infectious HIV-1 persist despite years of combination antiretroviral therapy and make curing HIV-1 infections a... περισσότερα »
What happens in vagus: a case of recurrent paraganglioma with malignant transformation and an updated treatment algorithm†.
*What happens in vagus: a case of recurrent paraganglioma with malignant transformation and an updated treatment algorithm†.* J Surg Case Rep. 2016;2016(2) Authors: Ertz-Archambault NM, Van Gompel JJ, Neff BA, Kasperbauer JL, Shamoun FE Abstract Paragangliomas (PGLs) are rare, extra-adrenal tumors, originating from neural crest cells and can occur anywhere from the skull base to the pelvic floor. Although these tumors are often benign, a fraction of malignant cases exist. Few isolated cases of malignant head and neck PGL are reported in the literature. Treatment algorithms rely h...περισσότερα »
Issue Information - TOC.
*Issue Information - TOC.* Head Neck. 2016 Mar;38(3):335-7 Authors: PMID: 26858149 [PubMed - in process] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1ormc6O via IFTTT
Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.
*Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.* BMC Cancer. 2015;16(1):70 Authors: Sun Y, Yu W, Sturgis EM, Peng W, Lei D, Wei Q, Song X, Li G Abstract BACKGROUND: FAS/FASL promoter variants are considered in altering transcriptional activity of those genes and consequently alter regulation of cell death. However, no studies have investigated whether tumor sites contribute to the association between FAS/FASL polymorphisms and risk for second primary malignancy (SPM). METHOD... περισσότερα »
Cochlear implantation is a therapeutic option for superficial siderosis patients with sensorineural hearing loss.
*Cochlear implantation is a therapeutic option for superficial siderosis patients with sensorineural hearing loss.* J Laryngol Otol. 2016 Feb 9;:1-4 Authors: Omichi R, Kariya S, Maeda Y, Nishizaki K Abstract BACKGROUND: Superficial siderosis is a rare disease that results from chronic bleeding in the subarachnoid space. Haemosiderin deposits throughout the subpial layers of the brain and spinal cord lead to progressive sensorineural hearing loss, which is seen in 95 per cent of patients with superficial siderosis. The impact of cochlear implantation on the quality of life of supe... περισσότερα »
Evaluation of the utricular and saccular function using oVEMPs and cVEMPs in BPPV patients.
*Evaluation of the utricular and saccular function using oVEMPs and cVEMPs in BPPV patients.* J Otolaryngol Head Neck Surg. 2016;45(1):12 Authors: Xu H, Liang FY, Chen L, Song XC, Tong MC, Thong JF, Zhang QQ, Sun Y Abstract BACKGROUND: It is well-known that ocular vestibular evoked myogenic potentials (oVEMPs) predominantly reflect utricular function whilst cervical vestibular evoked myogenic potentials (cVEMPs) reflect saccular function. To date, there are no published reports on the systemic evaluation of utricular and saccular function in benign paroxysmal positional vertigo (...περισσότερα »
Refining the head and neck cancer referral guidelines: a two centre analysis of 4715 referrals.
*Refining the head and neck cancer referral guidelines: a two centre analysis of 4715 referrals.* Br J Oral Maxillofac Surg. 2016 Feb;54(2):141-50 Authors: Tikka T, Pracy P, Paleri V Abstract Our aim was to identify the set of referral criteria that will offer optimal diagnostic efficacy in patients suspected to have head and neck cancer (HNC) in the primary care setting. We analysed the referral criteria and outcomes from two tertiary care cancer centres in the United Kingdom. Between 2007 and 2010, 4715 patients were referred via the fast track system with a suspected HNC. The ... περισσότερα »
Middle ear findings and need for ventilation tubes among pediatric cleft lip and palate patients in northern Finland.
*Middle ear findings and need for ventilation tubes among pediatric cleft lip and palate patients in northern Finland.* J Craniomaxillofac Surg. 2016 Jan 11; Authors: Lehtonen V, Lithovius RH, Autio TJ, Sándor GK, Ylikontiola LP, Harila V, Pesonen P, Koskinen S, Anttonen V Abstract PURPOSE: Middle ear problems are common in cleft patients. This study aimed to determine the need for ventilation tubes (VTs) and complications such as tympanic perforation and cholesteatoma. MATERIAL AND METHODS: Data of 156 children with clefts managed in northern Finland spanning 15 years from 1997 t...περισσότερα »
Telomere length, genetic variants and risk of squamous cell carcinoma of the head and neck in Southeast Chinese.
*Telomere length, genetic variants and risk of squamous cell carcinoma of the head and neck in Southeast Chinese.* Sci Rep. 2016;6:20675 Authors: Gu Y, Yu C, Miao L, Wang L, Xu C, Xue W, Du J, Yuan H, Dai J, Jin G, Hu Z, Ma H, Shen H Abstract Telomere dysfunction participates in malignant transformation and tumorigenesis. Previous studies have explored the associations between telomere length (TL) and cancer susceptibility; however, the findings are inconclusive. The associations between genetic variants and TL have been verified by quite a few genome-wide association studies (GW...περισσότερα »
Otologic Hazards Related to Scuba Diving.
*Otologic Hazards Related to Scuba Diving.* Sports Health. 2016 Feb 8; Authors: Glazer TA, Telian SA Abstract CONTEXT: As of 2015, more than 23 million scuba diver certifications have been issued across the globe. Given the popularity of scuba diving, it is incumbent on every physician to know and understand the specific medical hazards and conditions associated with scuba diving. EVIDENCE ACQUISITION: Sources were obtained from PubMed, MEDLINE, and EBSCO databases from 1956 onward and ranged from diverse fields including otologic reviews and wilderness medicine book chapters. STU...περισσότερα »
Novel human three-domain antibody fragments against sTNFα as well as tmTNFα with high affinity generated by the combination of ribosome display and E.coli expression system
Abstract Human tumor necrosis factor α (hTNFα) has been proved to be a validated therapeutic target in a number of immune-mediated inflammatory diseases (IMIDs). Fully human monoclonal antibodies (mAbs) that can neutralize soluble hTNFα (sTNFα) as well as transmembrane hTNFα (tmTNFα) are more desirable hTNFα antagonists. Here we report that novel anti-hTNFα human low molecular… Continue reading Novel human three-domain antibody fragments against sTNFα as well as tmTNFα with high affinity generated by the combination of ribosome display and E.coli expression system
Editorial Board/Reviewing Committee
Publication date: March 2016 Source:International Journal of Oral and Maxillofacial Surgery, Volume 45, Issue 3 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1T6MBSK via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LgzwQ5 via IFTTT
Sorafenib for the Treatment of Progressive Metastatic Medullary Thyroid Cancer: Efficacy and Safety Analysis
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1V39Goi via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RoRIxy via IFTTT
Antibacterial gauzes are effective in preventing infections after percutaneous endoscopic gastrostomy placement: a retrospective analysis
European Journal of Gastroenterology & Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQBC Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SfBCHA via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LgzwzR via IFTTT
Hepatocellular carcinoma in children: does modified platinum- and doxorubicin-based chemotherapy increase tumor resectability and change outcome? lessons learned from the SIOPEL 2 and 3 studies
Journal of Clinical Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUepz Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ms0cqK via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LgzwzP via IFTTT
Thyroid Imaging Reporting and Data System Risk Stratification of Thyroid Nodules: Categorization Based on Solidity and Echogenicity
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1KbtjKz via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RoRIxq via IFTTT
Serum 25-Hydroxyvitamin D Level Does Not Affect the Aggressiveness and Prognosis of Papillary Thyroid Cancer
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1KbtjKp via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LgzwzH via IFTTT
The variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent
Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQlc Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SfBCHu via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RoRIhc via IFTTT
The clinical management of abdominal ascites, spontaneous bacterial peritonitis and hepatorenal syndrome: a review of current guidelines and recommendations
European Journal of Gastroenterology & Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQl1 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ms0cqH via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LgzyYm via IFTTT
Multiple HBV quasispecies and immune-escape mutations are present in HBV surface antigen and reverse transcriptase of patients with acute hepatitis B
The Journal of Infectious Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUe9h Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ms09LE via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RoRJSd via IFTTT
Issue Information - TOC
No abstract is available for this article. from #Medicine via ola Kala on Inoreader http://ift.tt/1QV89zE via IFTTT
Issue Information - JIF
No abstract is available for this article. from #Medicine via ola Kala on Inoreader http://ift.tt/1KEYHB6 via IFTTT
Comment on “Ventricular non-compaction cardiomyopathy: prenatal diagnosis and pathology”
from #Medicine via ola Kala on Inoreader http://ift.tt/1QV89ja via IFTTT
Increased nuchal translucency and pregnancy outcome: a retrospective study of 1063 consecutive singleton pregnancies in a single referral institution
from #Medicine via ola Kala on Inoreader http://ift.tt/1QV89j0 via IFTTT
A randomized, double-blind, placebo-controlled phase II study to assess the efficacy and safety of mapatumumab with sorafenib in patients with advanced hepatocellular carcinoma
Annals of Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQRW via IFTTT
Metabolic effect of pancreatoduodenectomy: Resolution of diabetes mellitus after surgery
Pancreatology from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUeGk via IFTTT
Evaluation of advanced fibrosis measured by transient elastography after hepatitis C virus protease inhibitor-based triple therapy
European Journal of Gastroenterology & Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUeGe via IFTTT
Prevention of necrotizing enterocolitis through manipulation of the intestinal microbiota of the premature infant
Clinical Therapeutics from #Medicine via ola Kala on Inoreader http://ift.tt/20KSPxp via IFTTT
MiR-143 inhibits tumor cell proliferation and invasion by targeting STAT3 in esophageal squamous cell carcinoma
Cancer Letters from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUbKB via IFTTT
Levofloxacin, bismuth, amoxicillin and esomeprazole as second-line Helicobacter pylori therapy after failure of non-bismuth quadruple therapy
Digestive and Liver Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUepH via IFTTT
Antibacterial gauzes are effective in preventing infections after percutaneous endoscopic gastrostomy placement: a retrospective analysis
European Journal of Gastroenterology & Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQBC via IFTTT
Hepatocellular carcinoma in children: does modified platinum- and doxorubicin-based chemotherapy increase tumor resectability and change outcome? lessons learned from the SIOPEL 2 and 3 studies
Journal of Clinical Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUepz via IFTTT
The variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent
Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQlc via IFTTT
Multiple HBV quasispecies and immune-escape mutations are present in HBV surface antigen and reverse transcriptase of patients with acute hepatitis B
The Journal of Infectious Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUe9h via IFTTT
The clinical management of abdominal ascites, spontaneous bacterial peritonitis and hepatorenal syndrome: a review of current guidelines and recommendations
European Journal of Gastroenterology & Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQl1 via IFTTT
CA19-9 decrease at 8 weeks as a predictor of overall survival in a randomized phase III trial (MPACT) of weekly nab-paclitaxel plus gemcitabine vs gemcitabine alone in patients with metastatic pancreatic cancer
Annals of Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUe99 via IFTTT
Impact of smoking cessation on the clinical course of Crohn’s disease under current therapeutic algorithms: A multicenter prospective study
The American Journal of Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSOK5 via IFTTT
Clinical and immunologic features of ultra-short celiac disease
Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUbdF via IFTTT
Predicting the Occurrence of Hypotension in Stable Patients With Nonvariceal Upper Gastrointestinal Bleeding: Point-of-Care Lactate Testing
The Journal of Emergency Medicine from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQ4r via IFTTT
Randomized controlled trial of intraportal chemotherapy combined with adjuvant chemotherapy (mFOLFOX6) for stage II and III colon cancer
Annals of Surgery from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUbdD via IFTTT
Adverse events of gastric electrical stimulators recorded in the Manufacturer and User Device Experience (MAUDE) Registry
Autonomic Neuroscience: Basic and Clinical from #Medicine via ola Kala on Inoreader http://ift.tt/20KSOts via IFTTT
Increasing the interval between neoadjuvant chemoradiotherapy and surgery in rectal cancer: a meta-analysis of published studies
Annals of Surgery from #Medicine via ola Kala on Inoreader http://ift.tt/20KSOd5 via IFTTT
Diabetes-associated variation in TCF7L2 is not associated with hepatic or extrahepatic insulin resistance
Diabetes from #Medicine via ola Kala on Inoreader http://ift.tt/20KSOd2 via IFTTT
Terlipressin versus noradrenaline in the treatment of hepatorenal syndrome: systematic review with meta-analysis and full economic evaluation
European Journal of Gastroenterology & Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUbdp via IFTTT
Highly Efficient and Selective Isolation of Rare Tumor Cells Using a Microfluidic Chip with Wavy-herringbone Micro-patterned Surfaces
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C6AN00236F, Paper Shunqiang Wang, Antony Thomas, Elaine Lee, Shu Yang, Xuanhong Cheng, Yaling Liu Circulating tumor cells (CTCs) in peripheral blood have been recognized as a general biomarker for diagnosing cancer and providing guidance for personalized treatments. Yet due to their rarity, the challenge... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1KET1Hf via IFTTT
The use of brief post-surgical low frequency electrical stimulation to enhance nerve regeneration in clinical practice
Abstract Despite efforts to enhance peripheral nerve regeneration, there has been little progress in improving clinical outcomes. Recently, a method of brief post-surgical low frequency electrical stimulation of surgically repaired nerves has been developed. It was shown to accelerate axon outgrowth across the repair site and hastened target reinnervation. In this brief review, we describe the mechanistic insights and functional impacts of the post-surgical electrical stimulation that have been gained through animal studies. Brain derived neurotrophic factor, cyclic AMP and regen... περισσότερα »
Electrical synapses and the development of inhibitory circuits in the thalamus
Abstract Neurons within the mature thalamic reticular nucleus (TRN) powerfully inhibit ventrobasal (VB) thalamic relay neurons via GABAergic synapses. TRN neurons are also coupled to one another by electrical synapses that depend strongly on the gap junction protein connexin36 (Cx36). Electrical synapses in the TRN precede the postnatal development of TRN-to-VB inhibition. We investigated how the deletion of Cx36 affects the maturation of TRN and VB neurons, electrical coupling, and GABAergic synapses by studying wild-type (WT) and Cx36 knockout (KO) mice. The incidence and streng...περισσότερα »
The repair Schwann cell and its function in regenerating nerves
Abstract Nerve injury triggers the conversion of myelin and non-myelin (Remak) Schwann cells to a cell phenotype specialised to promote repair. Distal to damage, these repair Schwann cells provide the necessary signals and spatial cues for the survival of injured neurons, axonal regeneration and target reinnervation. The conversion to repair Schwann cells involves de-differentiation together with alternative differentiation, or activation, a combination that is typical of cell type conversions often referred to as (direct or lineage) reprogramming. Thus, injury-induced Schwann ce... περισσότερα »
Novel human three-domain antibody fragments against sTNFα as well as tmTNFα with high affinity generated by the combination of ribosome display and E.coli expression system
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Human tumor necrosis factor α (hTNFα) has been proved to be a validated therapeutic target in a number of immune-mediated inflammatory diseases (IMIDs). Fully human monoclonal antibodies (mAbs) that can neutralize soluble hTNFα (sTNFα) as well as transmembrane hTNFα (tmTNFα) are more desirable hTNFα antagonists. Here we report that novel anti-hTNFα human low molecular […]
Antibacterial gauzes are effective in preventing infections after percutaneous endoscopic gastrostomy placement: a retrospective analysis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
European Journal of Gastroenterology & Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQBC Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SfBCHA via IFTTT
Hepatocellular carcinoma in children: does modified platinum- and doxorubicin-based chemotherapy increase tumor resectability and change outcome? lessons learned from the SIOPEL 2 and 3 studies
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Journal of Clinical Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUepz Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ms0cqK via IFTTT
Thyroid Imaging Reporting and Data System Risk Stratification of Thyroid Nodules: Categorization Based on Solidity and Echogenicity
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1KbtjKz via IFTTT
The variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQlc Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SfBCHu via IFTTT
Sorafenib for the Treatment of Progressive Metastatic Medullary Thyroid Cancer: Efficacy and Safety Analysis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1V39Goi via IFTTT
Multiple HBV quasispecies and immune-escape mutations are present in HBV surface antigen and reverse transcriptase of patients with acute hepatitis B
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The Journal of Infectious Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/1WdUe9h Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ms09LE via IFTTT
Serum 25-Hydroxyvitamin D Level Does Not Affect the Aggressiveness and Prognosis of Papillary Thyroid Cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1KbtjKp via IFTTT
Editorial Board/Reviewing Committee
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:International Journal of Oral and Maxillofacial Surgery, Volume 45, Issue 3 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1T6MBSK via IFTTT
The clinical management of abdominal ascites, spontaneous bacterial peritonitis and hepatorenal syndrome: a review of current guidelines and recommendations
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
European Journal of Gastroenterology & Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/20KSQl1 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ms0cqH via IFTTT
