Salvage surgery for neck residue or recurrence of nasopharyngeal carcinoma after primary radiotherapy
: options of surgical methods and regions: Abstract BackgroundSalvage surgery has been recommended as the approach of choice for neck residue or recurrence of nasopharyngeal carcinoma (NPC) after primary radiotherapy (RT). This study aimed to assess the outcome and prognostic factors, options for different surgical methods, and the extent of neck dissection (ND) for patients. MethodsNPC patients who had undergone RT and received salvage surgery for neck residue or recurrence from January 2001 to December 2011 were retrospectively analyzed. The overall survival (OS) rate was cal... περισσότερα »
Cutaneous angiosarcoma of the head and face
: a single-center analysis of treatment outcomes in 43 patients in Japan: Abstract PurposeFor a better understanding of angiosarcoma, we summarized our 30-year experience of conventional treatment outcomes before the era of molecular-targeted therapy. MethodsWe conducted a retrospective review of our 43 patients with cutaneous angiosarcoma of the head and face, and investigated the prognostic factors including the treatment strategy. Disease-specific survival (DSS) and event-free survival (EFS) were estimated using the Kaplan–Meier method, together with multivariate analyses us... περισσότερα »
At least two well-spaced samples are needed to genotype a solid tumor.Two spatially-separated samples efficiently distinguish public from private mutations because private mutations common in one specimen are usually less frequent or absent in another sample.
At least two well-spaced samples are needed to genotype a solid tumor: Abstract BackgroundHuman cancers are often sequenced to identify mutations. However, cancers are spatially heterogeneous populations with public mutations in all cells and private mutations in some cells. Without empiric knowledge of how mutations are distributed within a solid tumor it is uncertain whether single or multiple samples adequately sample its heterogeneity. MethodsUsing a cohort of 12 human colorectal tumors with well-validated mutations, the abilities to correctly classify public and private mut... περισσότερα »
Comment Editorial independence: painful lessons
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Since they espouse unequivocal support for editorial independence, surely the leaders of the Canadian Medical Association (CMA) appreciate that firing effective editors of the Canadian Medical Association Journal (CMAJ)—as they did again in February, 2016, when they dismissed John Fletcher1—is a violation of the principles of editorial independence. Or do they? from #Medicine-SfakianakisAlexandros via o.lakala70 […]
Head and neck cancer: smoking,drinking,eating and sexual practices
Head and neck cancer: smoking, drinking, eating and…sexual practices via http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=10654&channel-name=European+Journal+of+Epidemiology COMMENTARY Head and neck cancer: smoking, drinking, eating and…sexual practices Lluis Serra-Majem1 Received: 23 February 2016 / Accepted: 15 March 2016 Springer Science+Business Media Dordrecht 2016 Head and neck cancers are among the most common cancers worldwide with nearly 600,000 new cases and 300,000 deaths occurring globally every year [1, 2]. These cancers include cancers ... περισσότερα »
Non-technical skills for surgeons (NOTSS) system
Introduction of the non-technical skills for surgeons (NOTSS) system in a Japanese cancer center: Abstract PurposeNon-technical skills rating systems, which are designed to support surgical performance, have been introduced worldwide, but not officially in Japan. We performed a pilot study to evaluate the “non-technical skills for surgeons” (NOTSS) rating system in a major Japanese cancer center. MethodsUpper gastrointestinal surgeons were selected as trainers or trainees. The trainers attended a master-class on NOTSS, which included simulated demo-videos, to promote consistenc... περισσότερα »
Mast cells in lymphomas
Mast cells in lymphomas via Critical Reviews in Oncology/Hematology (open access) Publication date: Available online 25 March 2016 *Source:*Critical Reviews in Oncology/Hematology Author(s): Domenico Ribatti Tumor microenvironment is involved in the pathogenesis and progression of human lymphomas. The lymphoma microenvironment is composed by stromal cells, immune cells (macrophages, plasma cells, mast cells, eosinophils, basophils, T- and B-cells), blood vessels and extracellular matrix proteins. This article is focused on the role of mast cells in lymphoma progression and angiogenesis... περισσότερα »
Smoking in pregnancy and risk of cancer among young children
A population-based study: Abstract Smoking during pregnancy is a plausible risk factor for childhood cancer, yet previous studies have yielded conflicting results, and few prospective studies have been published. Data on maternal smoking were obtained from California birth certificates. We linked California birth certificates (births 2007-2011) with California Cancer Registry records for childhood cancer cases (diagnosed January 2007- September 2013) that were ages 5 or younger at diagnosis (N cases=2,021). Controls (N=40,356) were frequency-matched by birth year and randomly selec... περισσότερα »
Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1
Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1 via ScienceDirect Publication: Cancer Epidemiology (open access) Publication date: June 2016 *Source:*Cancer Epidemiology, Volume 42 Author(s): Kimberly J. Johnson, Nancy L. Zoellner, David H. Gutmann BackgroundIndividuals with Neurofibromatosis Type 1 (NF1) are strongly predisposed to developing pediatric brain tumors (PBTs), especially optic pathway gliomas (OPGs). Although developmental factors have been implicated in the origins of PBTs in both human and animal studies, associations between early-l...περισσότερα »
Epigenetic mediated silencing of EYA4 contributes to tumorigenesis in oral dysplastic cells
Epigenetic mediated silencing of EYA4 contributes to tumorigenesis in oral dysplastic cells: Abstract Five-year survival rates for oral squamous cell carcinoma (OSCC) have remained at a dismal 50% for the past several decades. Molecular analyses of premalignant tissues are a key means of identifying early foundational drivers of disease, which may be exploitable as biomarkers or therapeutic targets for improving disease outcomes. We previously identified *EYA4* as frequently hypermethylated and silenced in premalignant disease based on an analysis of lesion-adjacent normal, dysplas...περισσότερα »
Post-Operative Spine Stereotactic Body Radiotherapy (SBRT)
: A critical review to guide practice via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 26 March 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): Kristin J. Redmond, Simon S. Lo, Charles Fisher, Arjun Sahgal Post-operative stereotactic body radiotherapy (SBRT) for metastatic spinal tumors is increasingly being performed in clinical practice. Whereas the fundamentals of SBRT practice for intact spinal metastases are established, there are as yet no comprehensive practice guidelines for the post-operativ...περισσότερα »
Cetuximab-induced skin rash and clinical outcome for head and neck cancer patients
Correlation between the severity of cetuximab-induced skin rash and clinical outcome for head and neck cancer patients: The XXXX experience via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 26 March 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): Voichita Bar-Ad, Qiang (Ed) Zhang, Paul M. Harari, Rita Axelrod, David I. Rosenthal, Andy Trotti, Christopher U. Jones, Adam S. Garden, Guobin Song, Robert L. Foote, David Raben, George Shenouda, Sharon A. Spencer, Jonathan Harris, Quynh-Thu Le PurposeThe pur...περισσότερα »
Comment Editorial independence: painful lessons
Since they espouse unequivocal support for editorial independence, surely the leaders of the Canadian Medical Association (CMA) appreciate that firing effective editors of the Canadian Medical Association Journal (CMAJ)—as they did again in February, 2016, when they dismissed John Fletcher1—is a violation of the principles of editorial independence. Or do they? from #Medicine-Sfakianakis via simeraentaxei… Continue reading Comment Editorial independence: painful lessons
About the numerical robustness of biomedical benchmark cases: Interlaboratory FDA's idealized medical device
Summary The need for reliable approaches in numerical simulations stands out as a critical issue for the development and optimization of cardiovascular biomedical devices. This led the United States Food and Drug Administration to undertake a program of validation of computational fluid dynamics methods for transitional and turbulent flows. In the current investigation, large-eddy simulation is used to simulate the flow in the first benchmark medical device and results are confronted to the existing laboratory experiments. This idealized medical device has the particularity to feat... περισσότερα »
Comparison of Inpatient and Outpatient Thyroidectomy
: Demographic and Economic Disparities via European Journal of Surgical Oncology (EJSO) Publication date: Available online 26 March 2016 *Source:*European Journal of Surgical Oncology (EJSO) Author(s): Zaid Al-Qurayshi, Sudesh Srivastav, Emad Kandil BackgroundThyroidectomy is increasingly being performed as an outpatient procedure. In this study, we aim to examine patient characteristics and clinical factors associated with outpatient thyroid surgeries as compared to inpatient procedures.MethodsA cross-sectional study for the period of 2007-2010. Inpatients and outpatients were selected... περισσότερα »
Polyurethane catheters are more susceptible to catheter-related infections and exhibit a higher thrombogenicity, compared to silicone catheters.
Polyurethane versus silicone catheters for central venous port devices implanted at the forearm via ScienceDirect Publication: European Journal of Cancer Publication date: May 2016 *Source:*European Journal of Cancer, Volume 59 Author(s): Moritz Wildgruber, Claudia Lueg, Sebastian Borgmeyer, Ilham Karimov, Ulrike Braun, Marion Kiechle, Reinhard Meier, Michael Koehler, Johannes Ettl, Hermann Berger PurposeWe aimed to analyse short and long-term complications of polyurethane (PU) versus silicone catheters used in totally implantable venous-access ports (TIVAPs) implanted at the forearm.M... περισσότερα »
The preoperative PLR is superior to NLR as an independent indicator in predicting disease-free survival and overall survival in patients who undergo oral cancer resection for OSCC.
The preoperative platelet-lymphocyte ratio versus neutrophil-lymphocyte ratio: which is better as a prognostic factor in oral squamous cell carcinoma?: Objective: Recent studies have shown that the presence of systemic inflammation and platelet status correlate with poor survival in various cancers. The aim of this study was to evaluate the prognostic value of the preoperative platelet–lymphocyte ratio (PLR) and the neutrophil–lymphocyte ratio (NLR) in patients with oral squamous cell carcinoma (OSCC) undergoing surgery. Methods: In this study, 306 patients with OSCC who had surger... περισσότερα »
Azole prophylaxis resulted in the expected efficacy—importantly, prior posaconazole prophylaxis did not render subsequent antifungal treatment less effective than prior itraconazole prophylaxis.
Outcome of empirical or targeted antifungal therapy after antifungal prophylaxis in febrile neutropenia: AbstractAzole prophylaxis has been shown to be effective in preventing invasive fungal infections (IFIs) and increasing survival in patients with prolonged neutropenia after myelosuppressive chemotherapy for haematological malignancies. Similarly, empirical antifungal therapy for persistent neutropenic fever has been shown to reduce IFI-related mortality. However, to date, there is little information with regard to the outcome of patients who receive both strategies. Here, we pr... περισσότερα »
Investigation of the effect of nanoparticle exposure on the flocculability of activated sludge using particle image volecimetry in combination with the extended DLVO analysis
Publication date: 1 July 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 143 Author(s): J. Xu, X.Y. Li With the application of nanotechnologies, nanoparticles (NPs) may enter the wastewater collection system, threatening the operation and stability of the treatment process. The present study investigated the effect of short-term exposures of activated sludge (AS) to NPs on… Continue reading Investigation of the effect of nanoparticle exposure on the flocculability of activated sludge using particle image volecimetry in combination with the extended DLVO analysis
Outcome of empirical or targeted antifungal therapy after antifungal prophylaxis in febrile neutropenia
Outcome of empirical or targeted antifungal therapy after antifungal prophylaxis in febrile neutropenia: AbstractAzole prophylaxis has been shown to be effective in preventing invasive fungal infections (IFIs) and increasing survival in patients with prolonged neutropenia after myelosuppressive chemotherapy for haematological malignancies. Similarly, empirical antifungal therapy for persistent neutropenic fever has been shown to reduce IFI-related mortality. However, to date, there is little information with regard to the outcome of patients who receive both strategies. Here, we pr... περισσότερα »
Radiation therapy (with or without neck surgery) for phenotypic human papillomavirus–associated oropharyngeal cancer
Radiation therapy (with or without neck surgery) for phenotypic human papillomavirus–associated oropharyngeal cancer: BACKGROUND Favorable outcomes for human papillomavirus–associated oropharyngeal cancer have led to interest in identifying a subgroup of patients with the lowest risk of disease recurrence after therapy. De-intensification of therapy for this group may result in survival outcomes that are similar to those associated with current therapy but with less toxicity. To advance this effort, this study analyzed the outcomes of oropharyngeal cancer patients treated with or w... περισσότερα »
Treatment trends and survival effects of chemotherapy for hypopharyngeal cancer
Treatment trends and survival effects of chemotherapy for hypopharyngeal cancer: Analysis of the National Cancer Data Base: [image: cover.gif?v=1&s=5845f3b7691e288599869125] BACKGROUND The current study was performed to characterize trends and survival outcomes for chemotherapy in the definitive and adjuvant treatment of hypopharyngeal cancer in the United States. METHODS A total of 16,248 adult patients diagnosed with primary hypopharyngeal cancer without distant metastases between 1998 and 2011 were identified in the National Cancer Data Base. The association between treatment ... περισσότερα »
Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma
Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma: Abstract BackgroundOesophageal adenocarcinoma (OAC) is increasingly common in the west, and survival remains poor at 10–15 % at 5 years. Immune responses are increasingly implicated as a determining factor of tumour progression. The ability of lymphocytes to recognise tumour antigens provides a mechanism for a host immune attack against cancer providing a potential treatment strategy. Materials and MethodsTumour infiltrating lymphocytes (TILs: CD3+, CD4+, CD8+ and FOXp...περισσότερα »
Awareness Towards Oral Cancer
Awareness of Undergraduate Dental and Medical Students Towards Oral Cancer: AbstractOral cancer is a common malignancy in Nepal and many other South East Asian countries, which is predisposed by a variety of potentially malignant oral diseases. Considering the importance of knowledge of health professionals and their role in early diagnosis and reduction of cancer statistics, this study aims to evaluate the awareness of undergraduate dental and medical students towards oral cancer. The study involved undergraduate dental and medical students of BP Koirala Institute of Health Scienc... περισσότερα »
CD4+ T-cell help in therapeutic cancer vaccination
CD4+ T-cell help in therapeutic cancer vaccination: While showing promise, vaccination strategies to treat cancer require further optimization. Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral tolerance, which limit the generation of effective vaccine-specific cytotoxic T lymphocytes (CTL). Since CD4+ T cells improve CTL responsiveness, next-generation vaccines include helper epitopes. Here we demonstrate in mice how CD4+ T cell help optimizes the CTL response to a clinically relevant DNA vaccine engineered to combat HPV-expressing tumors. Inclu...περισσότερα »
Characteristics, rates, and trends of melanoma incidence
among Hispanics in the USA: Abstract PurposeThe purpose of this study is to describe the epidemiology of melanoma among Hispanics using data that cover nearly 100 % of the US population. MethodsThe study used population-based cancer incidence data from the National Program of Cancer Registries and the Surveillance, Epidemiology and End Results Program to examine melanoma incidence rates and trends among Hispanics by sex, age, race, histology, anatomic location, stage, and tumor thickness. ResultsFrom 2008 to 2012, 6,623 cases of melanoma were diagnosed among Hispanics. Rat... περισσότερα »
Acceptance and commitment therapy in youth with neurofibromatosis type 1 (NF1) and chronic pain and their parents: A pilot study of feasibility and preliminary efficacy
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder affecting about 1 in 3,500 individuals. Chronic pain is commonly reported among individuals with NF1 and plexiform neurofibroma tumors (PNs). Acceptance and Commitment Therapy (ACT), an empirically supported method for addressing chronic pain, helps individuals re-focus on valued relationships and activities. This pilot study investigated the feasibility and preliminary efficacy of a brief ACT workshop in the NF1 population. Eligible participants included adolescents and young adults (AYA; 12–21 years) with ...περισσότερα »
About the numerical robustness of biomedical benchmark cases: Interlaboratory FDA's idealized medical device
Summary The need for reliable approaches in numerical simulations stands out as a critical issue for the development and optimization of cardiovascular biomedical devices. This led the United States Food and Drug Administration to undertake a program of validation of computational fluid dynamics methods for transitional and turbulent flows. In the current investigation, large-eddy simulation is used to simulate the flow in the first benchmark medical device and results are confronted to the existing laboratory experiments. This idealized medical device has the particularity to feat... περισσότερα »
For Primary CNS Lymphoma : Induction Chemotherapy With Methotrexate, Rituximab, and Temozolomide, Followed By Whole-Brain Radiotherapy and Postirradiation Temozolomide
Phase I and II Study of Induction Chemotherapy With Methotrexate, Rituximab, and Temozolomide, Followed By Whole-Brain Radiotherapy and Postirradiation Temozolomide for Primary CNS Lymphoma: NRG Oncology RTOG 0227 [Neurooncology]: Purpose This study investigated the treatment of primary CNS lymphoma with methotrexate, temozolomide (TMZ), and rituximab, followed by hyperfractionated whole-brain radiotherapy (hWBRT) and subsequent TMZ. The primary phase I end point was the maximum tolerated dose of TMZ. The primary phase II end point was the 2-year overall survival (OS) rate. Seconda... περισσότερα »
Functional outcome assessment of swallowing (FOAMS) scoring and videofluoroscopic evaluation of perioperative swallowing rehabilitation in radical esophagectomy
Functional outcome assessment of swallowing (FOAMS) scoring and videofluoroscopic evaluation of perioperative swallowing rehabilitation in radical esophagectomy: Abstract PurposeOropharyngeal swallowing dysfunction following esophagectomy has been associated with the surgical disruption of muscle strength and flexibility of the oropharyngeal structures. We assessed the value of perioperative swallowing rehabilitation (SR) in patients who underwent radical esophagectomy. MethodsWe instituted routine perioperative SR for patients with esophageal cancer and retrospectively compar... περισσότερα »
Performing endoscopic thyroidectomy using the Lap-protector and E·Z-access system, referred to as E·Z-access using video-assisted neck surgery (EZ-VANS)
Endoscopic thyroidectomy using the EZ-VANS method: Abstract PurposeSeveral video-assisted and robotic surgery techniques have been reported for resection of the thyroid and parathyroid glands. Our institute has started performing endoscopic thyroidectomy using the Lap-protector and E·Z-access system, referred to as E·Z-access using video-assisted neck surgery (EZ-VANS). In this report, we evaluate the safety and efficacy of this technique. MethodsFrom January 2007 to September 2014, 110 patients underwent resection of a primary thyroid tumor, 73 who underwent a cervical collar ...περισσότερα »
Apocrine mixed tumor is usually found in parotid glands.Apocrine mixed tumor of the eyelid
*: a case report: Apocrine mixed tumor is usually found in parotid glands. Its cutaneous counterpart is rare and its occurrence in the eyelids is even rarer. * Abstract Background *Apocrine mixed tumor is usually found in parotid glands. Its cutaneous counterpart is rare and its occurrence in the eyelids is even rarer.* Case presentation *This study reports an apocrine mixed tumor of the upper left eyelid in a 68 year-old lady with a history of breast cancer. This mass appeared about 3 years ago, as a slowly growing small nodule, and was completely excised. On microscopic examinat... περισσότερα »
Autism and chromosome abnormalities
A Review: Abstract The neuro-behavioral disorder of autism was first described in the 1940s and was predicted to have a biological basis. Since that time, with the growth of genetic investigations particularly in the area of pediatric development, an increasing number of children with autism and related disorders (autistic spectrum disorders, ASD) have been the subject of genetic studies both in the clinical setting and in the wider research environment. However, a full understanding of the biological basis of ASDs has yet to be achieved. Early observations of children with chromos... περισσότερα »
BRAF and MAP2K1 mutations in Langerhans cell histiocytosis
: a study of 50 cases via Human Pathology Publication date: June 2016 *Source:*Human Pathology, Volume 52 Author(s): Khaled Alayed, L. Jeffrey Medeiros, Keyur P. Patel, Zhuang Zuo, Shaoying Li, Shalini Verma, John Galbincea, R. Craig Cason, Rajyalakshmi Luthra, C. Cameron Yin Langerhans cell histiocytosis (LCH) is a proliferation of Langerhans cells, often associated with lymphocytes, eosinophils, macrophages, and giant cells. BRAF mutations, usually V600E, have been reported in 40%-70% of cases, and recently, MAP2K1 mutations have been reported in BRAF-negative cases. We assessed 50 ... περισσότερα »
Anatomocosmetic implication rules of the corrugator supercilii muscle for youthful eye appearance
Anatomocosmetic implication rules of the corrugator supercilii muscle for youthful eye appearance: AbstractThe dynamic balance of the eyebrows is maintained by the frontal muscle which acts as a brow elevator, and the brow depressors include corrugator supercilii muscle (CSM), procerus, depressor supercilii, and orbicularis oculi muscles. The glabellar rhytids might appear as a result of negative emotions, such as anger, anxiety, fatigue, fear, or disapproval. For youthful and calmer eyes, CSM may restore the muscle balance more safely and effectively for the treatments of forehead... περισσότερα »
Chronic allergic responses in tissue
Repeated FcεRI triggering reveals modified mast cell function related to chronic allergic responses in tissue via Allergy and Clinical Immunology Publication date: Available online 28 March 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Jolien Suurmond, Kim L.L. Habets, Zuotian Tatum, Joris J. Schonkeren, Peter A.C.'t Hoen, Tom W.J. Huizinga, Jeroen F.J. Laros, René E.M. Toes, Fina Kurreeman BackgroundActivation of mast cells through FcεRI plays an important role in acute allergic reactions. However, little is known about the function of mast cells in patients with... περισσότερα »
Standardization of allergen products: 3. validation of candidate european pharmacopoeia standard methods for quantification of major birch allergen bet v 1
Standardization of allergen products: 3. validation of candidate european pharmacopoeia standard methods for quantification of major birch allergen bet v 1: [image: cover.gif?v=1&s=eca9898eab49b7d92da2055c] Abstract Background The BSP090 project aims at establishing European Pharmacopoeia Reference Substances in combination with the corresponding ELISA methods for the quantification of major allergens in allergen products. Two sandwich ELISAs proved suitable for quantification of Bet v 1, the major birch pollen allergen, in preceding phases of BSP090. Methods Two Bet v 1-specifi... περισσότερα »
Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma
Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma: Abstract BackgroundOesophageal adenocarcinoma (OAC) is increasingly common in the west, and survival remains poor at 10–15 % at 5 years. Immune responses are increasingly implicated as a determining factor of tumour progression. The ability of lymphocytes to recognise tumour antigens provides a mechanism for a host immune attack against cancer providing a potential treatment strategy. Materials and MethodsTumour infiltrating lymphocytes (TILs: CD3+, CD4+, CD8+ and FOXp...περισσότερα »
Dangers of UV nail dryers
Need for Sun cream with your manicure? - Dangers of UV nail dryers: Over 102,000 cases of non-melanoma skin cancer (NMSC) were reported in 2011 with rates growing annually.1 The main NMSC is basal cell carcinoma accounting for 75%, with others including squamous cell carcinoma. It has been estimated that 90% of NMSC originates from exposure to UV light; which initiates malignant transformation in keratinocytes and reduces the protective inflammatory and immune.2 The increasing incidence has been attributed to an ageing population, rises in recreational activity associated with skin ...περισσότερα »
Zip-type skin-closing device and conventional staple device
Do zip-type skin-closing devices show better wound status compared to conventional staple devices in total knee arthroplasty?: Abstract This study compared the pain score, cosmetic outcome and wound complication rate between zip-type skin-closing device and conventional staple device. Forty-five subjects with zip-type skin-closing device (the zip group) and 45 subjects with the conventional staple device (the staple group) after total knee arthroplasty were compared. Visual analogue scale score was significantly higher on postoperative (PO) 1, 3, 14 day (D) in the staple group comp...περισσότερα »
What is a Caucasian “fine” hair?
What is a Caucasian “fine” hair? Comparing instrumental measurements, self-perceptions and assessments from hair experts: [image: cover.gif?v=1&s=dc9795a4011f7bb007aa66c4] Abstract Objective To determine the various factors contributing to what Caucasian women describe as “fine hair”. Methods Three complementary approaches were used, namely self-evaluation by the volunteer, assessment by a sensorial expert and instrumental measurements, in order to determine some of the possible parameters taken into account by Caucasian women when they describe the notion of fine hair. 151 women... περισσότερα »
Autophonic loudness perception in Parkinson's disease
Autophonic loudness perception in Parkinson's disease by François-Xavier Brajot, Douglas M. Shiller and Vincent L. Gracco via The Journal of the Acoustical Society of America: Most Recent Articles [image: cm_sbs_024_plain.png] The relationship between the intensity and loudness of self-generated (autophonic) speech remains invariant despite changes in auditory feedback, indicating that non-auditory processes contribute to this form of perception. The aim of the current study was to determine if the speech perception deficit associated with Parkinson's disease may be linked to deficits... περισσότερα »
What is a Caucasian “fine” hair? Comparing instrumental measurements, self-perceptions and assessments from hair experts
[image: cover.gif?v=1&s=dc9795a4011f7bb007aa66c4] Abstract Objective To determine the various factors contributing to what Caucasian women describe as "fine hair". Methods Three complementary approaches were used, namely self-evaluation by the volunteer, assessment by a sensorial expert and instrumental measurements, in order to determine some of the possible parameters taken into account by Caucasian women when they describe the notion of fine hair. 151 women of Caucasian origin participated in the study. They varied in age, and varied in that some considered themselves as hav... περισσότερα »
Intraoperative assessment of Ossicular Fixation
Intraoperative assessment of Ossicular Fixation via Hearing Research Publication date: Available online 28 March 2016 *Source:*Hearing Research Author(s): John Peacock, Joris Dirckx, Magnus von Unge Determining the degree of ossicular fixation is a difficult task, with the final assessment often being made with manual palpation during exploratory tympanotomy. A more objective method to evaluate ossicular fixation would be valuable.In this paper we describe a new method which makes use of a magnet and coil to measure ossicular motion through the ear canal with an elevated tympanic memb... περισσότερα »
Language Environment Analysis Measures for Spanish–English Bilingual Preschoolers From Migrant Low-Socioeconomic-Status Backgrounds
An Investigation of Language Environment Analysis Measures for Spanish–English Bilingual Preschoolers From Migrant Low-Socioeconomic-Status Backgrounds: Purpose The current study was designed to (a) describe average hourly Language Environment Analysis (LENA) data for preschool-age Spanish–English bilinguals (SEBs) and typically developing monolingual peers and (b) compare LENA data with mean length of utterance in words (MLUw) and total number of words (TNW) calculated on a selected sample of consecutive excerpts of audio files (CEAFs). Method Investigators examined average hour... περισσότερα »
Drowning patient resuscitation and monitoring
Drowning patient resuscitation and monitoring: By Kelly Grayson Drowning is a significant public health issue in the United States and worldwide, and represents a frequent need for resuscitation from EMS and emergency department providers. While the frequency of unintentional drowning has decreased over the last generation, roughly 10 people still die of drowning every day in the United States, 20 percent of which are ages 14 and under [1]. Drowning is the leading cause of unintentional traumatic death in children ages 1-4, the second-ranked cause of unintentional trauma deat... περισσότερα »
Retrograde intra-arterial chemotherapy and daily concurrent proton beam therapy for recurrent oral cavity SCC
Retrograde intra-arterial chemotherapy and daily concurrent proton beam therapy for recurrent oral cavity squamous cell carcinoma: Analysis of therapeutic results in 46 cases: Abstract Background The purpose of this study was to evaluate the efficacy and toxicities of proton beam therapy combined with intra-arterial infusion chemotherapy via superficial temporal and occipital arteries for recurrent oral cavity squamous cell carcinoma (SCC). Methods Between October 2009 and June 2013, 46 patients with recurrent oral cavity SCC were treated by proton beam therapy combined with intra-a... περισσότερα »
A New Genetic Deafness Microarray for Detecting Mutations in the Deaf
Application of a New Genetic Deafness Microarray for Detecting Mutations in the Deaf in China: by Hong Wu, Yong Feng, Lu Jiang, Qian Pan, Yalan Liu, Chang Liu, Chufeng He, Hongsheng Chen, Xueming Liu, Chang Hu, Yiqiao Hu, Lingyun Mei Objective The aim of this study was to evaluate the GoldenGate microarray as a diagnostic tool and to elucidate the contribution of the genes on this array to the development of both nonsyndromic and syndromic sensorineural hearing loss in China. Methods We developed a microarray to detect 240 mutations underlying syndromic and nonsyndromic sensor...περισσότερα »
Thyroglossal Duct Papillary Thyroid Carcinoma and Synchronous Lingual Thyroid Atypia
*Thyroglossal Duct Papillary Thyroid Carcinoma and Synchronous Lingual Thyroid Atypia: Thyroglossal duct and lingual thyroid ectopic lesions are exceedingly rare synchronous findings. Papillary thyroid carcinoma of these ectopic thyroid sites is well understood but still a rare finding. This case points to some management nuances in regard to ectopic thyroid screening with imaging and also shows the effectiveness of minimally invasive transoral robotic surgery for lingual thyroid. * 1. Introduction *Thyroid dysgenesis is a relatively common phenomenon that can manifest in sever... περισσότερα »
Paediatric tracheostomy and ventilation home care
with challenging socio-economic circumstances in South Africa via International Journal of Pediatric Otorhinolaryngology Publication date: May 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 84 Author(s): Ilse Groenendijk, Jane Booth, Monique van Dijk, Andrew Argent, Marco Zampoli BackgroundChildren discharged home with a tracheostomy need a safe home environment and access to health care. We described the indications, clinical characteristics, socio-economic circumstances and outcomes of children enroled in a tracheostomy home care programme in South Afri... περισσότερα »
Real life listening difficulties in children with suspected auditory processing disorder
Setting appropriate pass or fail cut-off criteria for tests to reflect real life listening difficulties in children with suspected auditory processing disorder via International Journal of Pediatric Otorhinolaryngology Publication date: May 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 84 Author(s): Ansar U. Ahmmed, Afsara A. Ahmmed ObjectiveThis paper explores the pass or fail cut-off criteria, the number of test fails, and the nature of tests that are most appropriate in predicting listening difficulties (LiD) in children with suspected APD (SusAPD).Met... περισσότερα »
Jaw osteoradionecrosis and dental extraction after head and neck radiotherapy
Jaw osteoradionecrosis and dental extraction after head and neck radiotherapy: A nationwide population-based retrospective study in Taiwan: [image: gr1.sml] Head and neck radiotherapy (R/T) combined (or not combined) with chemotherapy with/without surgery is the most effective way to ease the condition of head and neck cancers [1,2]. According to Chi et al., if head and neck R/T is applied, intensity-modulated radiation therapy (IMRT) or three-dimensional conformal radiation therapy (3D-CRT) is recommended [3]. Highlights - •Extraction time <0.5 year after R/T lowers the ... περισσότερα »
Endoscopic thyroidectomy using the EZ-VANS method
Abstract Purpose Several video-assisted and robotic surgery techniques have been reported for resection of the thyroid and parathyroid glands. Our institute has started performing endoscopic thyroidectomy using the Lap-protector and E·Z-access system, referred to as E·Z-access using video-assisted neck surgery (EZ-VANS). In this report, we evaluate the safety and efficacy of this technique. Methods From January 2007 to September 2014, 110 patients underwent resection of a primary thyroid tumor, 73 who underwent a cervical collar incision (the Open group) and 37 underwent EZ-VANS ... περισσότερα »
Association of genetic variants with tumor HPV16 status and survival in squamous cell carcinoma of the oropharynx
Association of genetic variants with tumor HPV16 status and survival in squamous cell carcinoma of the oropharynx: Squamous cell carcinoma of the oropharynx (SCCOP) is a subtype of squamous cell carcinoma of the head and neck (SCCHN) [1]. In the U.S., approximately 13,510 new cases of SCCOP are diagnosed, and 2330 deaths result from these cancers, annually [2]. Although tobacco smoking and alcohol consumption remain significant risk factors for SCCOP, human papillomavirus (HPV) accounts for a growing proportion of cases, particularly in young adults [1,3]. There are more than 100 di... περισσότερα »
Hormonal changes following a low-salt diet in patients with Ménière's disease
Hormonal changes following a low-salt diet in patients with Ménière's disease: A low-salt diet has been the main treatment modality for Ménière's disease (MD) since the 1930s, although the mechanisms behind this therapy have not yet been elucidated. Salt reduction is associated with a physiological increase in plasma aldosterone concentration. Several experimental reports have suggested that aldosterone may increase endolymph absorption in the inner ear, particularly in the endolymphatic sac. Therefore, aldosterone elevations due to a low-salt diet may increase endolymph absorption ...περισσότερα »
Biodegradable (NasoPore) and non-biodegradable packing
Clinical outcome and patient satisfaction using biodegradable (NasoPore) and non-biodegradable packing, a double-blind, prospective, randomized study via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 28 March 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Pawel Krzysztof Burduk, Malgorzata Wierzchowska, Blazej Grześkowiak, Wojciech Kaźmierczak, Katarzyna Wawrzyniak IntroductionNasal packing after endoscopic sinus surgery is used as a standard procedure. The optimum solution to minimize or eliminate all disadvant... περισσότερα »
Temporalis fascia muscle and full-thickness cartilage grafts in type 1 pediatric tympanoplasties
Comparison of via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 28 March 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Yakup Yegin, Mustafa Çelik, Arzu Karaman Koç, Levent Küfeciler, Mustafa Suphi Elbistanlı, Fatma Tülin Kayhan IntroductionVarious graft materials have been used to close tympanic membrane perforations. In the literature, there are few studies in pediatric populations comparing different graft materials. To our knowledge, there is no reported study that measured the thickness of the tragal cart... περισσότερα »
Refractory episodic vertigo
: role of intratympanic gentamicin and vestibular evoked myogenic potentials via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 28 March 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Erika Celis Aguilar, Ramón Hinojosa González, Olivia Vales Hidalgo, Heloisa Coutinho Toledo IntroductionEven today, the treatment of intractable vertigo remains a challenge. Vestibular ablation with intratympanic gentamicin stands as a good alternative in the management of refractory vertigo patients.ObjectiveTo control intractable ... περισσότερα »
The mean platelet volume and neutrophil-to-lymphocyte ratio in peritonsillar abscesses
The role of via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 28 March 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Mehmet Şentürk, İsa Azgın, Gültekin Övet, Necat Alataş, Betül Ağırgöl, Esra Yılmaz IntroductionPeritonsillar abscess (PTA) is a serious infectious disease of the tonsillar tissue. Treatment generally requires both medical and surgical approaches to relieve the symptoms. Recently, in addition to clinical follow-up, some inflammatory markers, such as the mean platelet volume (MPV) and neutrophil-... περισσότερα »
Drugs, Vol. 76, Issue 5 - New Issue Alert
If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 03/29/2016 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *Drugs*. Volume 76 Number 5 is now available online. In this issue Current Opinion Two-Drug Treatment Approaches in HIV: Finally Getting Somewhere? Sean G. Kelly, Amesika N. Nyaku & Babafemi O. Taiwo » Abstract » Full text HTML » Full text PDF Leading Article Serious Non-AIDS Events: Therapeutic Targets of Immune Activation and Chronic Inflammation... περισσότερα »
Endoplasmic reticulum stress up-regulates Nedd4-2 to induce autophagy Research
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The accumulation of unfolded proteins within the endoplasmic reticulum (ER) causes ER stress and activation of unfolded protein response (UPR). This response can trigger ER-associated degradation and autophagy, which clear unfolded proteins and restore protein homeostasis. Recently, it has become clear that ubiquitination plays an important role in the regulation of autophagy. In the present […]
Pharmacology of SERD inhibitor in breast cancer models
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Fulvestrant is an estrogen receptor (ER) antagonist administered to breast cancer patients by monthly intramuscular injection. Given its present limitations of dosing and route of administration, a more flexible orally available compound has been sought to pursue the potential benefits of this drug in patients with advanced metastatic disease. Here we report the identification and […]
AMPK Activation and Metabolic Reprogramming by Tamoxifen
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Tamoxifen is the most widely used adjuvant chemotherapeutic for the treatment of estrogen receptor (ER) positive breast cancer, yet a large body of clinical and preclinical data indicates that tamoxifen can modulate multiple cellular processes independently of ER status. Here, we describe the ER-independent effects of tamoxifen on tumor metabolism. Using combined pharmacological and genetic […]
CD4+ T-cell help in therapeutic cancer vaccination
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
While showing promise, vaccination strategies to treat cancer require further optimization. Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral tolerance, which limit the generation of effective vaccine-specific cytotoxic T lymphocytes (CTL). Since CD4+ T cells improve CTL responsiveness, next-generation vaccines include helper epitopes. Here we demonstrate in mice how CD4+ T cell help optimizes […]
PTP1B is a diet-dependent tumor suppressor in Pten-null PCa
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Diet affects the risk and progression of prostate cancer (PCa), but the interplay between diet and genetic alterations in this disease is not understood. Here we present genetic evidence in the mouse showing that PCa progression driven by loss of the tumor suppressor Pten is mainly unresponsive to a high fat diet (HFD), but that […]
Genetic Nrf2 activation in chemical lung carcinogenesis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Nrf2 activation promotes resistance to chemical carcinogenesis in animal models, but activating mutations in Nrf2 also confer malignant characters to human cells by activating anti-oxidative/detoxifying enzymes and metabolic reprogramming. In this study, we examined how these contradictory activities of Nrf2 – cancer chemoprevention and cancer cell growth enhancement – can be reconciled in an established […]
Early Adaption and Acquired Palbociclib Resistance
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Small-molecule inhibitors of the CDK4/6 cell-cycle kinases have shown clinical efficacy in estrogen receptor (ER)-positive metastatic breast cancer, although their cytostatic effects are limited by primary and acquired resistance. Here we report that ER-positive breast cancer cells can adapt quickly to CDK4/6 inhibition and evade cytostasis, in part, via noncanonical cyclin D1-CDK2–mediated S-phase entry. This […]
Near-infrared fluorescence imaging platform of nanoparticle spacers
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Markovic S, Belz J, Kumar R, Cormack RA, Sridhar S, Niedre M from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1RwEdbt via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
What is a Caucasian “fine” hair? Comparing instrumental measurements, self-perceptions and assessments from hair experts
[image: cover.gif?v=1&s=dc9795a4011f7bb007aa66c4] Abstract Objective To determine the various factors contributing to what Caucasian women describe as "fine hair". Methods Three complementary approaches were used, namely self-evaluation by the volunteer, assessment by a sensorial expert and instrumental measurements, in order to determine some of the possible parameters taken into account by Caucasian women when they describe the notion of fine hair. 151 women of Caucasian origin participated in the study. They varied in age, and varied in that some considered themselves as hav... περισσότερα »
Akt is a downstream effector of Trop-2
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose: Inhibition of Akt is a key target area for personalized cancer medicine. However, predictive markers of response to Akt inhibitors are lacking. Correspondingly unclear remains the Akt-dependent chain of command for tumor growth, which will mediate Akt-dependent therapeutic responses. Experimental design: Proteomic profilingwas utilized to identify nodal hubs of the Trop-2 cancer growth-driving network. […]
Investigation of the effect of nanoparticle exposure on the flocculability of activated sludge using particle image volecimetry in combination with the extended DLVO analysis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 1 July 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 143 Author(s): J. Xu, X.Y. Li With the application of nanotechnologies, nanoparticles (NPs) may enter the wastewater collection system, threatening the operation and stability of the treatment process. The present study investigated the effect of short-term exposures of activated sludge (AS) to NPs on […]
Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type-Specific Manner INNATE IMMUNITY AND INFLAMMATION
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The clathrin-dependent endocytic pathway is crucial for endosomal TLR3- and TLR4-mediated Toll–IL-1R domain–containing adaptor molecule-1 (TICAM-1) signaling. TLR4 uses a different signaling platform, plasma membrane and endosomes, for activation of TIRAP-MyD88 and TICAM-2–TICAM-1, respectively. LPS-induced endocytosis of TLR4 is mandatory for TICAM-1–mediated signaling including IFN-β production. Several molecules/mechanisms such as CD14, clathrin, and phosphatidylinositol metabolism […]
Restricting Glutamine or Glutamine-Dependent Purine and Pyrimidine Syntheses Promotes Human T Cells with High FOXP3 Expression and Regulatory Properties CLINICAL AND HUMAN IMMUNOLOGY
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
T cell subsets differ in their metabolic requirements, and further insight into such differences might be harnessed to selectively promote regulatory T cells (Tregs) for therapies in autoimmunity and transplantation. We found that Gln restriction during human T cell activation favored CD4 T cells with high expression of the Treg transcription factor FOXP3. This resulted […]
Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells CUTTING EDGE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Mice overexpressing B cell activating factor of the TNF family (BAFF) develop systemic autoimmunity characterized by class-switched anti-nuclear Abs. Transmembrane activator and CAML interactor (TACI) signals are critical for BAFF-mediated autoimmunity, but the B cell developmental subsets undergoing TACI-dependent activation in settings of excess BAFF remain unclear. We report that, although surface TACI expression is […]
TLR10 Is a Negative Regulator of Both MyD88-Dependent and -Independent TLR Signaling INNATE IMMUNITY AND INFLAMMATION
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
TLRs are central components of the innate immune system which, upon recognition of bacterial, fungal or viral components, activate intracellular signals that lead to protective inflammatory responses. Among the 10-member human TLR family, TLR10 is the only remaining orphan receptor without a known ligand or signaling function. Murine TLR10 is a disrupted pseudogene, which precludes […]
HIV-1-Mediated BAFF Secretion in Macrophages Does Not Require Endosomal TLRs, Type-I IFN, and Nef, but Depends on the Cellular Phenotype Status INFECTIOUS DISEASE AND HOST RESPONSE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
HIV-1 infection is characterized by persistent viral replication, chronic immune activation, and CD4+ T cell depletion. Moreover, several immune dysfunctions are observed in cells that are not targeted by the virus, such as B cells. Some B cell abnormalities include hypergammaglobulinemia, nonspecific B cell activation, class switching, increased cell turnover, breakage of tolerance, and a […]
Structural basis for the failure of the C1 domain of RasGRP2 to bind phorbol ester with high affinity Signal Transduction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The C1 domain represents the recognition module for diacylglycerol and phorbol esters in protein kinase C, RasGRP, and related proteins. RasGRP2 is exceptional, in that its C1 domain has very weak binding affinity (Kd = 2890 ± 240 nM for [3H]phorbol 12,13-dibutyrate ([3H]PDBu)). We have identified four amino acid residues responsible for this lack of […]
Helicase Activity Plays a Crucial Role for RNase R Function In Vivo and for RNA Metabolism Microbiology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
RNase R is a 3′ to 5′ hydrolytic exoribonuclease that has the unusual ability to digest highly structured RNA. The enzyme possesses an intrinsic, ATP-dependent RNA helicase activity that is essential in vitro for efficient nuclease activity against double-stranded RNA substrates, particularly at lower temperatures, with more stable RNA duplexes, and for duplexes with short […]
Regulation of RAGE ectodomain shedding and its role in cell function Cell Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand transmembrane receptor that can undergo proteolysis at the cell surface to release a soluble ectodomain. Here we observed that ectodomain shedding of RAGE is critical for its role in regulating signaling and cellular function. Ectodomain shedding of both human and mouse RAGE was dependent on […]
Corticosteroids compromise survival in glioblastoma
Glioblastoma is the most common and most aggressive primary brain tumour. Standard of care consists of surgical resection followed by radiotherapy and concomitant and maintenance temozolomide (temozolomide/radiotherapy->temozolomide). Corticosteroids are commonly used perioperatively to control cerebral oedema and are frequently continued throughout subsequent treatment, notably radiotherapy, for amelioration of side effects. The effects of corticosteroids such as dexamethasone on cell growth in glioma models and on patient survival have remained controversial. We performed a retr... περισσότερα »
Rifampicin is a candidate preventive medicine against amyloid {beta} and tau oligomers
Amyloid-β, tau, and α-synuclein, or more specifically their soluble oligomers, are the aetiologic molecules in Alzheimer's disease, tauopathies, and α-synucleinopathies, respectively. These proteins have been shown to interact to accelerate each other's pathology. Clinical studies of amyloid-β-targeting therapies in Alzheimer's disease have revealed that the treatments after disease onset have little benefit on patient cognition. These findings prompted us to explore a preventive medicine which is orally available, has few adverse effects, and is effective at reducing neurotoxic o... περισσότερα »
Sequential Changes in Cortical Excitation during Orthodontic Treatment
Cortical excitation responding to periodontal ligament (PDL) stimulation is observed in the rat primary somatosensory (S1), secondary somatosensory, and insular oral region of the cortex (S2/IOR), which are considered to process somatosensation, including nociception. Our previous studies have demonstrated that excitatory propagation induced by PDL stimulation is facilitated in S1 and S2/IOR 1 d after experimental tooth movement (ETM), and tetanic stimulation of IOR induces long-term potentiation of cortical excitatory propagation consistently. These findings raise the possibility ...περισσότερα »
Hierarchical CT to Ultrasound Registration of the Lumbar Spine: A Comparison with Other Registration Methods
Abstract Three-dimensional (3D) measurement of the spine can provide important information for functional, developmental, diagnostic, and treatment-effect evaluations. However, existing measurement techniques are either 2-dimensional, highly invasive, or involve a high radiation dose, prohibiting their widespread and repeated use in both research and clinical settings. Non-invasive, non-ionizing, 3D measurement of the spine is still beyond the current state-of-the-art. Towards this goal, we developed an intensity-based hierarchical CT-ultrasound registration approach to quantify t... περισσότερα »
Structural basis for the failure of the C1 domain of RasGRP2 to bind phorbol ester with high affinity Signal Transduction
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The C1 domain represents the recognition module for diacylglycerol and phorbol esters in protein kinase C, RasGRP, and related proteins. RasGRP2 is exceptional, in that its C1 domain has very weak binding affinity (Kd = 2890 ± 240 nM for [3H]phorbol 12,13-dibutyrate ([3H]PDBu)). We have identified four amino acid residues responsible for this lack of […]
Helicase Activity Plays a Crucial Role for RNase R Function In Vivo and for RNA Metabolism Microbiology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
RNase R is a 3′ to 5′ hydrolytic exoribonuclease that has the unusual ability to digest highly structured RNA. The enzyme possesses an intrinsic, ATP-dependent RNA helicase activity that is essential in vitro for efficient nuclease activity against double-stranded RNA substrates, particularly at lower temperatures, with more stable RNA duplexes, and for duplexes with short […]
Regulation of RAGE ectodomain shedding and its role in cell function Cell Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand transmembrane receptor that can undergo proteolysis at the cell surface to release a soluble ectodomain. Here we observed that ectodomain shedding of RAGE is critical for its role in regulating signaling and cellular function. Ectodomain shedding of both human and mouse RAGE was dependent on […]
Evolution of Heat Sensors Drove Shifts in Thermosensation between Xenopus Species Adapted to Different Thermal Niches Neurobiology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Temperature is one of the most critical environmental factors affecting survival, thus species that inhabit different thermal niches have evolved thermal sensitivities suitable for their respective habitats. During the process of shifting thermal niches, various types of genes expressed in diverse tissues, including those of the peripheral to central nervous systems, are potentially involved in […]
Benzothiazole Amphiphiles Promote the Formation of Dendritic Spines in Primary Hippocampal Neurons Molecular Bases of Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The majority of excitatory synapses in the brain exist on dendritic spines. Accordingly, the regulation of dendritic spine density in the hippocampus is thought to play a central role in learning and memory. The development of novel methods to control spine density could, therefore, have important implications for treatment of a host of neurodegenerative and […]
Structure-Function Relationships in L-Amino Acid Deaminase, a Flavoprotein Belonging to a Novel Class of Biotechnologically Relevant Enzymes Protein Structure and Folding
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
L-Amino acid deaminase from Proteus myxofaciens (PmaLAAD) is a membrane flavoenzyme which catalyzes the deamination of neutral and aromatic L-amino acids into α-keto acids and ammonia. PmaLAAD does not use dioxygen to re-oxidize reduced FADH2 and thus does not produce hydrogen peroxide; instead, it uses cytochrome b-like protein as electron acceptor. Although the overall fold […]
Fine Tuning of Substrate Affinity Leads to Alternative Roles of Mycobacterium tuberculosis Fe2+-ATPases Microbiology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Little is known about iron efflux transporters within bacterial systems. Recently, the participation of Bacillus subtilis PfeT, a P1B4-ATPase, in cytoplasmic Fe2+ efflux has been proposed. We report here the distinct roles of mycobacterial P1B4-ATPases in the homeostasis of Co2+ and Fe2+. Mutation of Mycobacterium smegmatis ctpJ affects the homeostasis of both ions. Alternatively, a […]
TIR-TcpC ameliorates experimental autoimmune arthritis by down-modulating Th17 cell response Immunology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Evasion through immuno-modulation is one of the several strategies adopted by pathogens to prolong their survival within host. One such pathogen, E.coli CFT073 utilizes an immuno-modulatory protein TcpC to combat the hosts innate immune defence. TcpC abrogates the function of MyD88 in macrophages thus perturbing all the signaling processes that involve this adaptor protein. Although […]
Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-Related Hepatocellular Carcinoma in Mice Immunology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The role of Toll-like receptor (TLR) signaling has attracted much attention in the development of hepatic inflammation and hepatocellular carcinoma (HCC). We herein sought to determine the role of TLRs and responsible cells in steatohepatitis-related HCC. We used hepatocyte-specific Pten deficient (PtenΔhep) mice, which exhibit steatohepatitis followed by liver tumor formation including HCC. We then […]
Modeling the Etiology of P53-Mutated Cancer Cells Gene Regulation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
P53 gene mutations are among the most common alterations in cancer. In most cases, missense mutations in one TP53 allele are followed by loss-of-heterozygosity (LOH), so tumors express only mutant p53. TP53 mutations and LOH have been linked, in many cases, with poor therapy response and worse outcome. Despite this, remarkably little is known about […]
Characteristics, rates, and trends of melanoma incidence among Hispanics in the USA
Abstract Purpose The purpose of this study is to describe the epidemiology of melanoma among Hispanics using data that cover nearly 100 % of the US population. Methods The study used population-based cancer incidence data from the National Program of Cancer Registries and the Surveillance, Epidemiology and End Results Program to examine melanoma incidence rates and trends among Hispanics by sex, age, race, histology, anatomic location, stage, and tumor thickness. Results From 2008 to 2012, 6,623 cases of melanoma were diagnosed among Hispanics. Rates were higher among males (4.6... περισσότερα »
Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type-Specific Manner INNATE IMMUNITY AND INFLAMMATION
The clathrin-dependent endocytic pathway is crucial for endosomal TLR3- and TLR4-mediated Toll–IL-1R domain–containing adaptor molecule-1 (TICAM-1) signaling. TLR4 uses a different signaling platform, plasma membrane and endosomes, for activation of TIRAP-MyD88 and TICAM-2–TICAM-1, respectively. LPS-induced endocytosis of TLR4 is mandatory for TICAM-1–mediated signaling including IFN-β production. Several molecules/mechanisms such as CD14, clathrin, and phosphatidylinositol metabolism… Continue reading Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Sign... περισσότερα »
Restricting Glutamine or Glutamine-Dependent Purine and Pyrimidine Syntheses Promotes Human T Cells with High FOXP3 Expression and Regulatory Properties CLINICAL AND HUMAN IMMUNOLOGY
T cell subsets differ in their metabolic requirements, and further insight into such differences might be harnessed to selectively promote regulatory T cells (Tregs) for therapies in autoimmunity and transplantation. We found that Gln restriction during human T cell activation favored CD4 T cells with high expression of the Treg transcription factor FOXP3. This resulted… Continue reading Restricting Glutamine or Glutamine-Dependent Purine and Pyrimidine Syntheses Promotes Human T Cells with High FOXP3 Expression and Regulatory Properties CLINICAL AND HUMAN IMMUNOLOGY
Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells CUTTING EDGE
Mice overexpressing B cell activating factor of the TNF family (BAFF) develop systemic autoimmunity characterized by class-switched anti-nuclear Abs. Transmembrane activator and CAML interactor (TACI) signals are critical for BAFF-mediated autoimmunity, but the B cell developmental subsets undergoing TACI-dependent activation in settings of excess BAFF remain unclear. We report that, although surface TACI expression is… Continue reading Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells CUTTING EDGE
TLR10 Is a Negative Regulator of Both MyD88-Dependent and -Independent TLR Signaling INNATE IMMUNITY AND INFLAMMATION
TLRs are central components of the innate immune system which, upon recognition of bacterial, fungal or viral components, activate intracellular signals that lead to protective inflammatory responses. Among the 10-member human TLR family, TLR10 is the only remaining orphan receptor without a known ligand or signaling function. Murine TLR10 is a disrupted pseudogene, which precludes… Continue reading TLR10 Is a Negative Regulator of Both MyD88-Dependent and -Independent TLR Signaling INNATE IMMUNITY AND INFLAMMATION
HIV-1-Mediated BAFF Secretion in Macrophages Does Not Require Endosomal TLRs, Type-I IFN, and Nef, but Depends on the Cellular Phenotype Status INFECTIOUS DISEASE AND HOST RESPONSE
HIV-1 infection is characterized by persistent viral replication, chronic immune activation, and CD4+ T cell depletion. Moreover, several immune dysfunctions are observed in cells that are not targeted by the virus, such as B cells. Some B cell abnormalities include hypergammaglobulinemia, nonspecific B cell activation, class switching, increased cell turnover, breakage of tolerance, and a… Continue reading HIV-1-Mediated BAFF Secretion in Macrophages Does Not Require Endosomal TLRs, Type-I IFN, and Nef, but Depends on the Cellular Phenotype Status INFECTIOUS DISEASE AND HOST RESPONSE
Structural basis for the failure of the C1 domain of RasGRP2 to bind phorbol ester with high affinity Signal Transduction
The C1 domain represents the recognition module for diacylglycerol and phorbol esters in protein kinase C, RasGRP, and related proteins. RasGRP2 is exceptional, in that its C1 domain has very weak binding affinity (Kd = 2890 ± 240 nM for [3H]phorbol 12,13-dibutyrate ([3H]PDBu)). We have identified four amino acid residues responsible for this lack of… Continue reading Structural basis for the failure of the C1 domain of RasGRP2 to bind phorbol ester with high affinity Signal Transduction
Helicase Activity Plays a Crucial Role for RNase R Function In Vivo and for RNA Metabolism Microbiology
RNase R is a 3′ to 5′ hydrolytic exoribonuclease that has the unusual ability to digest highly structured RNA. The enzyme possesses an intrinsic, ATP-dependent RNA helicase activity that is essential in vitro for efficient nuclease activity against double-stranded RNA substrates, particularly at lower temperatures, with more stable RNA duplexes, and for duplexes with short… Continue reading Helicase Activity Plays a Crucial Role for RNase R Function In Vivo and for RNA Metabolism Microbiology
Regulation of RAGE ectodomain shedding and its role in cell function Cell Biology
The Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand transmembrane receptor that can undergo proteolysis at the cell surface to release a soluble ectodomain. Here we observed that ectodomain shedding of RAGE is critical for its role in regulating signaling and cellular function. Ectodomain shedding of both human and mouse RAGE was dependent on… Continue reading Regulation of RAGE ectodomain shedding and its role in cell function Cell Biology
Evolution of Heat Sensors Drove Shifts in Thermosensation between Xenopus Species Adapted to Different Thermal Niches Neurobiology
Temperature is one of the most critical environmental factors affecting survival, thus species that inhabit different thermal niches have evolved thermal sensitivities suitable for their respective habitats. During the process of shifting thermal niches, various types of genes expressed in diverse tissues, including those of the peripheral to central nervous systems, are potentially involved in… Continue reading Evolution of Heat Sensors Drove Shifts in Thermosensation between Xenopus Species Adapted to Different Thermal Niches Neurobiology
Benzothiazole Amphiphiles Promote the Formation of Dendritic Spines in Primary Hippocampal Neurons Molecular Bases of Disease
The majority of excitatory synapses in the brain exist on dendritic spines. Accordingly, the regulation of dendritic spine density in the hippocampus is thought to play a central role in learning and memory. The development of novel methods to control spine density could, therefore, have important implications for treatment of a host of neurodegenerative and… Continue reading Benzothiazole Amphiphiles Promote the Formation of Dendritic Spines in Primary Hippocampal Neurons Molecular Bases of Disease
Modeling the Etiology of P53-Mutated Cancer Cells Gene Regulation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
P53 gene mutations are among the most common alterations in cancer. In most cases, missense mutations in one TP53 allele are followed by loss-of-heterozygosity (LOH), so tumors express only mutant p53. TP53 mutations and LOH have been linked, in many cases, with poor therapy response and worse outcome. Despite this, remarkably little is known about […]
Do Src kinase and Caveolin interact directly with Na,K-ATPase? Membrane Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Much evidence points to a role of Na,K-ATPase in ouabain-dependent signal transduction. Based on experiments with different cell lines and native tissue membranes, a current hypothesis postulates direct interactions between the Na,K-ATPase and Src kinase (non-receptor tyrosine kinase). Na,K-ATPase is proposed to bind Src kinase and inhibit its activity, while ouabain, the specific Na,K-ATPase inhibitor, […]
PilN binding modulates the structure and binding partners of the Pseudomonas aeruginosa Type IVa Pilus protein PilM Protein Structure and Folding
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that expresses type IVa pili (T4aP). The pilus assembly system, which promotes surface-associated twitching motility and virulence, is comprised of inner and outer membrane subcomplexes, connected by an alignment subcomplex composed of PilMNOP. PilM binds to the N-terminus of PilN, and we hypothesize that this interaction causes functionally […]
Regulation of cell wall plasticity by nucleotide metabolism in Lactococcus lactis Microbiology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
To ensure optimal cell growth and separation, and to adapt to environmental parameters, bacteria have to maintain a balance between cell wall (CW) rigidity and flexibility. This can be achieved by a concerted action of peptidoglycan (PG) hydrolases and PG synthesizing/modifying enzymes. In a search for new regulatory mechanisms responsible for the maintenance of this […]
The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyl Transferase and the PGC-1{alpha} Transcriptional Coactivator Signal Transduction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Methionine is an essential sulfur amino acid that is engaged in key cellular functions such as protein synthesis, and is a precursor for critical metabolites involved in maintaining cellular homeostasis. In mammals, in response to nutrient conditions, the liver plays a significant role in regulating methionine concentrations by altering its flux through the transmethylation, transsulfuration […]
A Modeling and Experimental Investigation of the Effects of Antigen Density, Binding Affinity, and Antigen Expression Ratio on Bispecific Antibody Binding to Cell Surface Targets Immunology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Despite the increasing number of multivalent antibodies, bispecific antibodies, fusion proteins, and targeted nanoparticles that have been generated and studied, the mechanism of multivalent binding to cell surface targets is not well understood. Here, we describe a conceptual and mathematical model of multivalent antibody binding to cell surface antigens. Our model predicts that properties beyond […]
Ground-based GNSS network and integrated water vapor mapping during the development of severe storms at the Cuyo region (Argentina)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 1 July–1 August 2016 Source:Atmospheric Research, Volumes 176–177 Author(s): A. Calori, J.R. Santos, M. Blanco, H. Pessano, P. Llamedo, P. Alexander, A. de la Torre Mendoza is a province of Argentina located between 32° S and 34° S at the leeside of the Andes Foothills. Very intense thunderstorms form between October and March […]
The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein*
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Journal of Biological Chemistry from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RouwiB via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1–3*
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Journal of Biological Chemistry from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1MOE5Sz via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
A high-throughput in vivo micronucleus assay for genome instability screening in mice
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nature protocols from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RouuaE via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use? [ARTICLE]
RNA-seq is now the technology of choice for genome-wide differential gene expression experiments, but it is not clear how many biological replicates are needed to ensure valid biological interpretation of the results or which statistical tools are best for analyzing the data. An RNA-seq experiment with 48 biological replicates in each of two conditions was performed to answer these questions and provide guidelines for experimental design. With three biological replicates, eight of the 11 tools evaluated found only 20%–40% of the significantly differentially expressed (SDE) genes i... περισσότερα »
Development of novel strontium containing bioactive glass based calcium phosphate cement
Publication date: Available online 28 March 2016 *Source:*Dental Materials Author(s): A. D'Onofrio, N.W. Kent, S.A. Shahdad, R.G. Hill ObjectiveThe aim of this study was to investigate the effect on properties of increasing strontium substitution for calcium in bioactive glasses used as precursors for novel calcium phosphate cements.MethodsGlasses were produced by progressively substituting strontium for calcium. Cements were prepared by mixing the glass powder with Ca(H2PO4)2 powder with a 2.5% solution of Na2HPO4. Setting times and compressive strength were measured after 1h, 1 da... περισσότερα »
Two-body wear rate of PEEK, CAD/CAM resin composite and PMMA: Effect of specimen geometries, antagonist materials and test set-up configuration
Publication date: Available online 28 March 2016 *Source:*Dental Materials Author(s): Timea Wimmer, Anne Mildred Sophie Huffmann, Marlis Eichberger, Patrick R. Schmidlin, Bogna Stawarczyk ObjectiveTo test and compare the two-body wear rate of three CAD/CAM polymer materials and the influence of specimen geometry, antagonist material and test set-up configuration.MethodsThree CAD/CAM polymeric materials were assessed: a thermoplastic polyetheretherketone (PEEK), an experimental nanohybrid composite (COMP) and a PMMA-based material (PMMA). Crown-shaped and flat specimens were prepared... περισσότερα »
Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma
Background In glioblastoma (GBM), Id1 serves as a functional marker for self-renewing cancer stem-like cells. We investigated the mechanism by which cyclooxygenase-2 (Cox-2)-derived prostaglandin E2 (PGE2) induces Id1 and increases GBM self-renewal and radiation resistance. Methods Mouse and human GBM cells were stimulated with dimethyl-PGE2 (dmPGE2), a stabilized form of PGE2, to test for Id1 induction. To elucidate the signal transduction pathway governing the increase in Id1, a combination of short interfering RNA knockdown and small molecule inhibitors and activators of PGE... περισσότερα »
Phase 1 trial of p28 (NSC745104), a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in pediatric patients with recurrent or progressive central nervous system tumors: A Pediatric Brain Tumor Consortium Study
Background p53 is a promising target in human cancer. p28 is a cell-penetrating peptide that preferentially enters cancer cells and binds to both wild-type and mutant p53 protein, inhibiting COP1-mediated ubiquitination and proteasomal degradation. This results in increased levels of p53, which induces cell cycle arrest at G2/M. We conducted a phase 1 study to determine the maximum-tolerated dose (MTD) and describe the dose-limiting toxicities (DLTs) and pharmacokinetics (PKs) of p28 in children. Methods Children aged 3–21 years with recurrent or progressive central nervous sys... περισσότερα »
Biology and management of ependymomas
Ependymomas are rare primary tumors of the central nervous system in children and adults that comprise histologically similar but genetically distinct subgroups. The tumor biology is typically more associated with the site of origin rather than being age-specific. Genetically distinct subgroups have been identified by genomic studies based on locations in classic grade II and III ependymomas. They are supratentorial ependymomas with *C11orf95-RELA* fusion or *YAP1* fusion, infratentorial ependymomas with or without a hypermethylated phenotype (CIMP), and spinal cord ependymomas. M...περισσότερα »
