Galacto-oligosaccharides (GOS) are prebiotics added to commercial milk formula of infants and mothers. In recent years, cases of allergy related to GOS in atopic children have been reported in the South East A...
http://ift.tt/2kyMlBK
Πέμπτη 9 Φεβρουαρίου 2017
An unusual cause of food-induced anaphylaxis in mothers
Progress with Structure-Activity Relationship modelling of occupational chemical respiratory sensitizers.
Purpose of review: This appraises currently available computer-based ('in silico') models relating the molecular structure of low molecular weight compounds to their respiratory sensitization hazard. The present review places focus on the two main applications of such structure--activity relationship (SAR) models: hypotheses on disease mechanisms and toxicological prediction. Recent findings: Analyses of the chemical structures of low molecular weight organic compounds known to have caused occupational asthma has led to the development of mechanistic alerts usually based on electrophilic reaction chemistry and protein cross-linking potential. Protein cross-linking potential has also been found to be a consistent feature of chemicals that have caused human cases of hypersensitivity pneumonitis. Stepwise iteration of quantitative SAR (QSAR) modelling has shown appreciable improvements in predictivity for occupational asthma hazard and useful prospects for practical application. A good case has also been made for the potential use of structural alert-based mechanistic SARs in predictive toxicology. Summary: Further understanding of the molecular interactions between chemical respiratory sensitizers and components of human proteins has been obtained from in-vitro and in-silico techniques. There have been developments in both qualitative (mechanistic) SARs and QSARs, which offer potential for use in a predictive algorithm for the toxicological screening of industrial chemicals for respiratory sensitization potential. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
http://ift.tt/2kVgtYO
http://ift.tt/2kVgtYO
Building school health partnerships to improve pediatric asthma care: the school-based asthma management program.
Purpose of review: Children with asthma require care that is seamlessly coordinated so that asthma symptoms are recognized and managed at home and at school. The purpose of this review is to discuss recent consensus recommendations in school-based asthma care. Recent findings: The School-based Asthma Management Program (SAMPRO(TM)) provides a widely endorsed framework to coordinate care with schools and consists of four components: establishing a circle of support around the child with asthma; facilitating bidirectional communication between clinicians and schools; comprehensive asthma education for schools; and assessment and remediation of environmental asthma triggers at school. SAMPRO standardizes recommendations for school-based asthma care coordination and provides a toolkit with websites and resources useful for the care of children with asthma in the school setting. Summary: The review will discuss the need for coordinated school asthma partnerships, the inception and development of SAMPRO, and its vision to improve pediatric asthma care coordination within the circle of support, comprised of clinicians, school nurses, families, and communities. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
http://ift.tt/2kalWGS
http://ift.tt/2kalWGS
Silicosis and autoimmunity.
Purpose of review: Of the various environmental, occupational, and medical substances that cause dysregulation of autoimmunity, the effects and causative mechanisms of silica particles and asbestos fibers are discussed in this review. Recent findings: With respect to silica, many epidemiological studies have shown a significant association between silica exposure and the occurrence of autoimmune diseases. Although the importance of the NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome as the initial immune reaction against silica particles has been identified, the mechanisms involved that lead to various autoimmune diseases in patients exposed to silica remain largely unknown. Silica can activate various immune cells and investigation of the associated imbalance of regulatory T cells, responder T cells as well as Th17 cells might be key in furthering our understanding of silica-induced autoimmune alterations. On the other hand, asbestos exposure shows less association with autoimmune diseases. However, interesting findings pertaining to the detection of antiendothelial and mesothelial cell antibodies in asbestos-exposed patients have been reported. Summary: Taken together, further investigations may contribute in delineating the mechanisms involved in environmental factor-induced modification of autoimmunity. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
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http://ift.tt/2luNjfS
Genetics in OtolRhinoLaryngology
08:35
Authors: Savva I, Pierides A, Deltas CAbstract Alport syndrome (AS) is a hereditary progressive glomerulonephritis with a high life-time risk for end-stage renal disease (ESRD). Most patients will reach ESRD before the age of 30 years, while a subset of them with milder mutations will do so...
08:35
Authors: Tang ZH, Chen JR, Zheng J, Shi HS, Ding J, Qian XD, Zhang C, Chen JL, Wang CC, Li L, Chen JZ, Yin SK, Huang TS, Chen P, Guan MX, Wang JFAbstractUNLABELLED: The genetic correction of induced pluripotent stem cells (iPSCs) induced from somatic cells of patients with sensorineural hearing loss...
08:34
Genetics: A New Frontier in OtologyIndian J Otolaryngol Head Neck Surg.Authors: Kameswaran M, Sudhamaheswari S, Natarajan KAbstractMolecular genetics is a rapidly expanding field with possibilities for novel diagnostic and treatment strategies for otological diseases. Gene therapy, if theory is proven...
08:29
Long-Term Follow-Up with Video of a Patient with Deafness-Dystonia Syndrome Treated with DBS-GPi.: Authors: Dulski J, Schinwelski M, Mandat T, Pienczk-Ręcławowicz K, Sławek JAbstract BACKGROUND: The prevalence of deafness-dystonia syndrome (DDS) is relatively low. To our knowledge, only 2 cases...
08:28
Authors: Riccardi S, Bergling S, Sigoillot F, Beibel M, Werner A, Leighton-Davies J, Knehr J, Bouwmeester T, Parker CN, Roma G, Kinzel BAbstract BACKGROUND: Hearing loss is the most common sensory defect afflicting several hundred million people worldwide. In most cases, regardless of the original...
08:28
Advances and unmet needs in genetic, basic and clinical science in Alport syndrome: report from the 2015 International Workshop on Alport Syndrome.: Authors: Gross O, Kashtan CE, Rheault MN, Flinter F, Savige J, Miner JH, Torra R, Ars E, Deltas C, Savva I, Perin L, Renieri A, Ariani F, Mari F, Baigent...
08:27
Identification of Adeno-Associated Viral Vectors That Target Neonatal and Adult Mammalian Inner Ear Cell Subtypes.:Hum Gene Ther.Authors: Shu Y, Tao Y, Wang Z, Tang Y, Li H, Dai P, Gao G, Chen ZYAbstract The mammalian inner ear consists of diverse cell types with important functions. Gene mutations...
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Authors: Ingham NJ, Carlisle F, Pearson S, Lewis MA, Buniello A, Chen J, Isaacson RL, Pass J, White JK, Dawson SJ, Steel KPAbstract Progressive hearing loss is very common in the population but we still know little about the underlying pathology. A new spontaneous mouse mutation (stonedeaf,...
08:26
Authors: Adeyemo AA, Oluwatosin O, Omotade OOAbstract Hearing impairment is due to various causes including ototoxicity from aminoglycosides. The susceptibility to aminoglycosides increases in the presence of certain mitochondria gene mutations. There is unrestrained use of aminoglycosides...
08:25
Authors: Nikopoulos K, Farinelli P, Giangreco B, Tsika C, Royer-Bertrand B, Mbefo MK, Bedoni N, Kjellström U, El Zaoui I, Di Gioia SA, Balzano S, Cisarova K, Messina A, Decembrini S, Plainis S, Blazaki SV, Khan MI, Micheal S, Boldt K, Ueffing M, Moulin AP, Cremers FP, Roepman R, Arsenijevic Y, Tsilimbaris...
08:24
Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (Krabbe's disease).: Authors: Bradbury AM, Bagel JH, Jiang X, Swain GP, Prociuk ML, Fitzgerald CA, O'Donnell PA, Braund KG, Ory DS, Vite CHAbstract Globoid...
08:23
Related Articles Inhibition of Skp2 sensitizes lung cancer cells to paclitaxel. Onco Targets Ther. 2017;10:439-446 Authors: Huang T, Yang L, Wang G, Ding G, Peng B, Wen Y, Wang Z Abstract S-phase kinase-associated protein 2 (Skp2) is an E3 ubiquitin ligase and plays an important role in the control...
08:23
Related Articles Maximizing Synergistic Activity When Combining RNAi and Platinum-based Anticancer Agents. J Am Chem Soc. 2017 Feb 06;: Authors: Xiao H, Qi R, Li T, Awuah SG, Zheng Y, Wei W, Kang X, Song H, Wang Y, Yu Y, Bird MA, Jing X, Yaffe MB, Birrer MJ, Ghoroghchian PP Abstract RNAi approaches...
08:23
Authors: Fukunaga I, Fujimoto A, Hatakeyama K, Aoki T, Nishikawa A, Noda T, Minowa O, Kurebayashi N, Ikeda K, Kamiya KAbstract Mutation of the Gap Junction Beta 2 gene (GJB2) encoding connexin 26 (CX26) is the most frequent cause of hereditary deafness worldwide and accounts for up to 50% of...
08:22
Authors: Hu J, Li B, Apisa L, Yu H, Entenman S, Xu M, Stepanyan R, Guan BJ, Müller U, Hatzoglou M, Zheng QYAbstractHearing loss is one of the most common sensory impairments in humans. Mouse mutant models helped us to better understand the mechanisms of hearing loss. Recently, we have discovered that...
08:18
Variants in WFS1 and other Mendelian deafness genes are associated with cisplatin-associated ototoxicityClin Cancer Res.Authors: Wheeler HE, Gamazon ER, Frisina R, Perez-Cervantes C, El Charif O, Mapes B, Fossa SD, Feldman D, Hamilton R, Vaughn DJ, Beard C, Fung C, Kollmannsberger C, Kim J, Mushiroda...
08:17
Authors: Slijkerman RW, Vaché C, Dona M, García-García G, Claustres M, Hetterschijt L, Peters TA, Hartel BP, Pennings RJ, Millan JM, Aller E, Garanto A, Collin RW, Kremer H, Roux AF, Van Wijk EAbstract Usher syndrome (USH) is the most common cause of combined deaf-blindness in man. The hearing...
08:17
Authors: Jang JH, Jung J, Kim AR, Cho YM, Kim MY, Lee SY, Choi JY, Lee JH, Choi BYAbstractMutations in the SLC26A4 gene, which encodes pendrin, cause congenital hearing loss as a manifestation of Pendred syndrome (PS) with an iodide organification defect or nonsyndromic enlarged vestibular aqueduct...
08:16
Authors: Mathur P, Yang JAbstract Usher syndrome (USH), clinically and genetically heterogeneous, is the leading genetic cause of combined hearing and vision loss. USH is classified into three types, based on the hearing and vestibular symptoms observed in patients. Sixteen loci have been...
08:16
Authors: Taura A, Taura K, Koyama Y, Yamamoto N, Nakagawa T, Ito J, Ryan AFAbstract Once inner ear hair cells (HCs) are damaged by drugs, noise or aging, their apical structures including the stereociliary arrays are frequently the first cellular feature to be lost. Although this can be followed...
08:16
Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV.:Mol Ther. 2017 Feb 01;25(2):379-391Authors: György B, Sage C, Indzhykulian AA, Scheffer DI, Brisson AR, Tan S, Wu X, Volak A, Mu D, Tamvakologos PI, Li Y, Fitzpatrick Z, Ericsson M, Breakefield XO, Corey DP, Maguire...
08:16
Authors: Shu Y, Tao Y, Li W, Shen J, Wang Z, Chen ZYAbstract Mammalian inner ear harbors diverse cell types that are essential for hearing and balance. Adenovirus is one of the major vectors to deliver genes into the inner ear for functional studies and hair cell regeneration. To identify adenovirus...
08:10
A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear.:Nat Biotechnol. 2017 Feb 06;:Authors: Landegger LD, Pan B, Askew C, Wassmer SJ, Gluck SD, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR, Vandenberghe LHAbstractEfforts to develop gene therapies for hearing...
08:08
Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c.:Nat Biotechnol. 2017 Feb 06;:Authors: Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GSAbstractBecause there are currently...
08:04
Sangeetha Yoganathan, Sniya Valsa Sudhakar, Gautham Arunachal, Maya Thomas, Annadurai Subramanian, Renu George, Sumita Danda Annals of Indian Academy of Neurology 2017 20(1):62-68 Background: Menkes disease (MD) is an X-linked recessive neurodegenerative disorder caused by mutations in ATP7A gene....
08:02
Pradeep Kumar, Shubham Misra, Amit Kumar, Mohammad Faruq, Sunil Shakya, Gyan Vardhan, Subiah Vivekanandhan, Achal Kumar Srivastava, Kameshwar Prasad Annals of Indian Academy of Neurology 2017 20(1):5-12 Background: Transforming growth factor-beta 1 (TGF-β1) is a multifunctional pleiotropic cytokine...
08:01
Josef Finsterer, Salma Majid Wakil, Franco Laccone Annals of Indian Academy of Neurology 2017 20(1):75-76 http://ift.tt/2kUXAFy
06:41
Publication date: Available online 9 February 2017Source:International Journal of Psychophysiology Author(s): Thomas Plieger, Martin Melchers, Annabel Vetterlein, Janina Görtz, Sarah Kuhn, Melissa Ruppel, Martin Reuter IntroductionEmotion regulation is an important everyday-life skill to reduce harm...
05:18
Recent studies revealed that the inhibition of mitochondrial oxidative phosphorylation (OXPHOS) is coupled with the mitochondrial unfolded protein response, thereby stimulating the secretion of non-cell-autonomous factors, which may control systemic energy metabolism and longevity. However, the nature...
03:16
by Hao Pan, Liqun Gu, Binjie Liu, Yiping Li, Yuehong Wang, Xinna Bai, Long Li, Baisheng Wang, Qian Peng, Zhigang Yao, Zhangui TangIt is widely accepted that oral squamous cell carcinoma (OSCC) is a major contributor to the incidence and mortality of neck and head cancer. Tropomyosin-1 (TPM1), which is...
01:21
Publication date: Available online 9 February 2017Source:Journal of Dairy Science Author(s): M.X. Rodrigues, S.F. Lima, S.G. Canniatti-Brazaca, R.C. Bicalho Numerous studies have evaluated associations between bacterial groups and milk quality parameters. However, to our knowledge, no research has...
01:21
Publication date: Available online 8 February 2017Source:Journal of Dairy Science Author(s): M.L.S. Bicalho, T. Santin, M.X. Rodrigues, C.E. Marques, S.F. Lima, R.C. Bicalho We investigated the microbiota found in the vaginas of Holstein dairy cows during the transition period and described the differences...
Thu Feb 09, 2017 23:12
Publication date: March 2017Source:Neurobiology of Aging, Volume 51 Author(s): William Sproviero, Aleksey Shatunov, Daniel Stahl, Maryam Shoai, Wouter van Rheenen, Ashley R. Jones, Safa Al-Sarraj, Peter M. Andersen, Nancy M. Bonini, Francesca L. Conforti, Philip Van Damme, Hussein Daoud, Maria Del Mar...
Thu Feb 09, 2017 23:12
Publication date: March 2017Source:Neurobiology of Aging, Volume 51 Author(s): Natalya V. Ponomareva, Tatiana V. Andreeva, Maria S. Protasova, Lef I. Shagam, Daria D. Malina, Andrey Yu. Goltsov, Vitaly F. Fokin, Sergey N. Illarioshkin, Evgeny I. Rogaev Genome-wide association studies have identified...
Thu Feb 09, 2017 22:52
AbstractThe human leukocyte antigen (HLA) system is a major part of the human immune system and has an impact on tumor initiation, tumor progression, and immunosurveillance. Renal cell carcinoma tumors are considered to be immunogenic. Therefore, we studied the allele frequencies of four gene loci (HLA-A,...
Thu Feb 09, 2017 20:51
Publication date: Available online 9 February 2017Source:Annals of Diagnostic Pathology Author(s): Anastasia M. Konstantinova, Tomas Vanecek, Petr Martinek, Liubov Kyrpychova, Dominic V. Spagnolo, Colin J.R. Stewart, Francesca Portelli, Michal Michal, Dmitry V. Kazakov Lesions affecting anogenital...
Thu Feb 09, 2017 20:33
by Rubar Hussein M. Salih, Ľuboš Majeský, Trude Schwarzacher, Richard Gornall, Pat Heslop-Harrison Chloroplast DNA sequences show substantial variation between higher plant species, and less variation within species, so are typically excellent markers to investigate evolutionary, population and genetic...
Thu Feb 09, 2017 19:50
Summary Ectodermal dysplasia-skin fragility syndrome (ED-SFS) is an autosomal recessive genodermatosis characterized by skin fragility, chronic cheilitis, palmoplantar keratoderma, abnormal hair growth and nail dystrophy. ED-SFS is caused by mutations in the PKP1 gene encoding pakophilin-1 (PKP1),...
Thu Feb 09, 2017 16:47
Publication date: Available online 8 February 2017Source:Human Pathology Author(s): Sejin Jang, Mineui Hong, Mi Kyung Shin, Byung Chun Kim, Hyung-Sik Shin, Eunsil Yu, Seung-Mo Hong, Jihun Kim, Sung Min Chun, Tae-Im Kim, Kyung-Chan Choi, Young Woong Ko, Jeong Won Kim Tumor budding (TB) in colorectal...
Thu Feb 09, 2017 16:46
Publication date: Available online 8 February 2017Source:Human Pathology Author(s): Tomoko Kitaichi, Kohichiroh Yasui, Yasuyuki Gen, Osamu Dohi, Naoto Iwai, Akira Tomie, Nobuhisa Yamada, Kei Terasaki, Atsushi Umemura, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Yoshio Sumida, Hironori...
Thu Feb 09, 2017 15:12
Abstract Objectives Somatic mutations of the PIK3CA, CASP8 and NOTCH1 have been frequently detected in various human cancers. Our study aims to analyze the mutational status of these genes in South Indian oral cancers. Subjects and Methods We performed mutational analysis of the PIK3CA (exons 9 &...
Thu Feb 09, 2017 14:56
Related Articles An Up-to-date Approach to a Patient with a Suspected Autoinflammatory Disease. Rambam Maimonides Med J. 2017 Jan 30;8(1): Authors: Lidar M, Giat E Abstract Autoinflammatory diseases (AID) are characterized by seemingly unprovoked self-limited attacks of fever and systemic inflammation...
Thu Feb 09, 2017 14:51
Related Articles An example of the utility of genomic analysis for fast and accurate clinical diagnosis of complex rare phenotypes. Orphanet J Rare Dis. 2017 Feb 07;12(1):24 Authors: Le Quesne Stabej P, James C, Ocaka L, Tekman M, Grunewald S, Clement E, Stanescu HC, Kleta R, Morrogh D, Calder A,...
Thu Feb 09, 2017 13:06
Publication date: Available online 9 February 2017Source:Cancer Genetics Author(s): Annette Y. Sunga, Charité Ricker, Carin R. Espenschied, Danielle Castillo, Marilena Melas, Josef Herzog, Sarah Bannon, Marcia Cruz-Correa, Patrick Lynch, Ilana Solomon, Stephen B. Gruber, Jeffrey N. Weitzel Lynch syndrome...
Thu Feb 09, 2017 07:41
Publication date: Available online 8 February 2017Source:Vaccine Author(s): Courtney Jarrahian, Annie Rein-Weston, Gene Saxon, Ben Creelman, Greg Kachmarik, Abhijeet Anand, Darin Zehrung IntroductionIntradermal delivery of a fractional dose of inactivated poliovirus vaccine (IPV) offers potential benefits...
Thu Feb 09, 2017 04:51
Publication date: 8 February 2017Source:Cell Host & Microbe, Volume 21, Issue 2 Author(s): Sarah E. Carden, Gregory T. Walker, Jared Honeycutt, Kyler Lugo, Trung Pham, Amanda Jacobson, Donna Bouley, Juliana Idoyaga, Renee M. Tsolis, Denise Monack Genome degradation correlates with host adaptation...
Thu Feb 09, 2017 04:06
Publication date: Available online 8 February 2017Source:American Journal of Infection Control Author(s): Laura Pedersen, Kimberly Elgin, Barbara Peace, Nadia Masroor, Michelle Doll, Kakotan Sanogo, Wilhelm Zuelzer, Gene Peterson, Michael P. Stevens, Gonzalo Bearman We examined the perceptions and...
Thu Feb 09, 2017 01:58
by Xinli Lu, Xianjiang Kang, Yongjian Liu, Ze Cui, Wei Guo, Cuiying Zhao, Yan Li, Suliang Chen, Jingyun Li, Yuqi Zhang, Hongru Zhao New human immunodeficiency virus type 1 (HIV-1) diagnoses are increasing rapidly in Hebei. The aim of this study presents the most extensive HIV-1 molecular epidemiology...
Thu Feb 09, 2017 01:41
Publication date: February 2017Source:Pediatric Neurology, Volume 67 Author(s): Ahmed Al-Rumayyan, Christine Klein, Majid Alfadhel BackgroundEarly-onset parkinsonism can be caused by PTEN-induced putative kinase 1 (PINK1) gene defects and is usually characterized by an age of onset in the fourth decade...
Thu Feb 09, 2017 01:06
Esophageal cancer is a disease with disappointing prognosis. Currently, there are no predictive factors that can identify patients who on the one hand would likely benefit from tri-modality management and, on the other hand, would not be significantly affected by the morbidity accompanying the treatment....
Wed Feb 08, 2017 21:19
by Ayelén Melisa Blanco, Miguel Gómez-Boronat, Ángel Luis Alonso-Gómez, Roman Yufa, Suraj Unniappan, María Jesús Delgado, Ana Isabel Valenciano Ghrelin is the only known hormone posttranslationally modified with an acylation. This modification is crucial for most of ghrelin's physiological effects and...
Wed Feb 08, 2017 21:19
by André Golldack, Björn Henke, Bärbel Bergmann, Marie Wiechert, Holger Erler, Alexandra Blancke Soares, Tobias Spielmann, Eric Beitz Resistance against all available antimalarial drugs calls for novel compounds that hit unexploited targets in the parasite. Here, we show that the recently discovered...
Wed Feb 08, 2017 16:07
Publication date: Available online 7 February 2017Source:Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms Author(s): Regina Andrade Menezes, Catarina Pimentel, Ana Rita Courelas Silva, Catarina Amaral, Jawad Merhej, Frédéric Devaux, Claudina Rodrigues-Pousada Response to arsenic stress...
Wed Feb 08, 2017 15:11
Publication date: April 2017Source:International Immunopharmacology, Volume 45 Author(s): Helena Cucak, Lise Høj Thomsen, Alexander Rosendahl The metabolic syndrome has been demonstrated in gene deficient animals, e.g. db/db mice, to include a systemic inflammation leading to insulin resistance, obesity...
Wed Feb 08, 2017 14:40
Abstract Objective This study aimed to explore the role of acute exercise on skeletal muscle gene expression related to insulin resistance in patients with polycystic ovary syndrome (PCOS) and controls. Methods Four obese women with PCOS and 4 body controls subjects (CTRL) participated...
Wed Feb 08, 2017 14:16
Trigeminal Neuralgia TreatmentTrigeminal neuralgia, also called tic doulourex, is a rare neurological disease that causes sudden, severe, brief, stabbing recurrent episodes of facial pain in one or more branches of the trigeminal nerve. It is usually caused when the trigeminal nerve is being compressed...
Wed Feb 08, 2017 12:36
Publication date: Available online 8 February 2017Source:Seminars in Cancer Biology Author(s): Mohammad Alam Jafri, Mohammed Hussein Al-Qahtani, Jerry William Shay Metastasis is the spread and growth of localized cancer to new locations in the body and is considered the main cause of cancer-related...
Wed Feb 08, 2017 12:07
Publication date: Available online 8 February 2017Source:Journal of Allergy and Clinical ImmunologyAuthor(s): Eskil Kreiner, Johannes Waage, Marie Standl, Susanne Brix, Tune H. Pers, Alexessander Couto Alves, Nicole M. Warrington, Carla MT. Tiesler, Elaine Fuertes, Lude Franke, Joel N. Hirschhorn, Alan...
Wed Feb 08, 2017 11:20
Yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ) co-operate with numerous transcription factors to regulate gene transcriptions. YAP1 and TAZ are negatively regulated by the tumor suppressive Hippo pathway. In human cancers, the Hippo pathway is frequently...
Wed Feb 08, 2017 08:10
A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear. Nat Biotechnol. 2017 Feb 06;: Authors: Landegger LD, Pan B, Askew C, Wassmer SJ, Gluck SD, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR, Vandenberghe LH Abstract Efforts to develop gene therapies for...
Wed Feb 08, 2017 08:10
Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c. Nat Biotechnol. 2017 Feb 06;: Authors: Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GS Abstract Because there...
Wed Feb 08, 2017 08:06
The Effect of Botulinum Toxin Type A on Expression Profiling of Long Noncoding RNAs in Human Dermal Fibroblasts: Objective. This study was aimed at analyzing the expressions of long noncoding RNAs (lncRNAs) in Botulinum Toxin Type A (BoNTA) treated human dermal fibroblasts (HDFs) in vitro. Methods. We...
Wed Feb 08, 2017 08:02
Global and Local Connectivity Differences Converge With Gene Expression in a Neurodevelopmental Disorder of Known Genetic Origin: <span class="paragraphSection"><div class="boxTitle">Abstract</div>Knowledge of genetic cause in neurodevelopmental disorders can highlight molecular and...
Wed Feb 08, 2017 06:47
Publication date: April 2017Source:Biomaterials, Volume 124 Author(s): Shih-Chun Lo, Kuei-Chang Li, Yu-Han Chang, Mu-Nung Hsu, Li-Yu Sung, Truong Anh Vu, Yu-Chen Hu Calvarial bone repair remains challenging for adults. Although adipose-derived stem cells (ASCs) hold promise to heal bone defects,...
Wed Feb 08, 2017 06:26
Wed Feb 08, 2017 05:43
Publication date: Available online 7 February 2017Source:Archives of Oral Biology Author(s): Li-Jiao Chen, Bi-Bo Hu, Xin-Lian Shi, Man-Man Ren, Wen-Bin Yu, Sheng-Dan Cen, Rong-Dang Hu, Hui Deng ObjectivePeriodontium regeneration is one of the most important processes for periodontitis therapy. Human...
Wed Feb 08, 2017 05:42
Publication date: Available online 7 February 2017Source:Archives of Oral Biology Author(s): Li-Jiao Chen, Bi-Bo Hu, Xin-Lian Shi, Man-Man Ren, Wen-Bin Yu, Sheng-Dan Cen, Rong-Dang Hu, Hui Deng ObjectivePeriodontium regeneration is one of the most important processes for periodontitis therapy. Human...
Wed Feb 08, 2017 05:40
Pamela Christudoss, Geeta Chacko, Ratnasamy Selvakumar, Jude Joseph Fleming, Srinivasan Pugazhendhi, George Mathew Journal of Cancer Research and Therapeutics 2016 12(4):1307-1312 Aim: Metallothionein (MT) is a small protein with a high affinity for divalent heavy metals and has a function in zinc...
Wed Feb 08, 2017 05:38
Y Swarnalatha, Bhaswti Saha Journal of Cancer Research and Therapeutics 2016 12(4):1284-1290 Aim of the Study: The current study is aimed to isolate and study the efficacy of the anticancer activity of endophytic bacteria from adhatoda beddomei leaves. Endophytic bacteria, microorganisms can found...
Wed Feb 08, 2017 05:37
Reyhaneh Nassiri Mansour, Seyed Ehsan Enderami, Abdolreza Ardeshirylajimi, Koorosh Fooladsaz, Mojtaba Fathi, Shahla Moahammad Ganji Journal of Cancer Research and Therapeutics 2016 12(4):1313-1317 Aim of Study: Colorectal cancer (CRC) is the fourth most prevalent cancer globally. Several factors have...
Wed Feb 08, 2017 05:37
Elaheh Eskandari, Esfandiar Heidarian, Sayed Asadollah Amini, Javad Saffari-Chaleshtori Journal of Cancer Research and Therapeutics 2016 12(4):1266-1271 Objective: One of the most common malignancies among men is prostate cancer. Ellagic acid (EA), a polyphenol antioxidant, has many pharmacological...
Wed Feb 08, 2017 05:36
Fathima Dhilhani Mohamed Faleel, M. I. M. De Zoysa, M. D. S. Lokuhetti, Y. I. N. S. Gunawardena, Vishvanath Naduviladath Chandrasekharan, Ranil Samantha Dassanayake Journal of Cancer Research and Therapeutics 2016 12(4):1272-1277 Aim: Mutations in K-ras codon 12 and 13 of exon 2 are known to affect...
Wed Feb 08, 2017 05:21
Sung-Hyun Byun, Juwan Kim, Dasol Han, Mookwang Kwon, Jae Youl Cho, Hui Xuan Ng, Samuel J. Pleasure, and Keejung YoonTransactivation response element RNA-binding protein (TRBP) is known to play important roles in human immunodeficiency virus (HIV) replication and microRNA biogenesis. However, recent studies...
Wed Feb 08, 2017 05:21
Lorna Taylor, Daniel F. Carlson, Sunil Nandi, Adrian Sherman, Scott C. Fahrenkrug, and Michael J. McGrewIn this work we use TALE nucleases (TALENs) to target a reporter construct to the DDX4 (vasa) locus in chicken primordial germ cells. Vasa is a key germ cell determinant in many animal species and...
Wed Feb 08, 2017 05:21
Claire S. Simon, Damien J. Downes, Matthew E. Gosden, Jelena Telenius, Douglas R. Higgs, Jim R. Hughes, Ita Costello, Elizabeth K. Bikoff, and Elizabeth J. RobertsonThe T-box transcription factor (TF) Eomes is a key regulator of cell fate decisions during early mouse development. The cis-acting regulatory...
Wed Feb 08, 2017 04:40
Abstract To assess the different sensitivity to ozone (O3) between transgenic Bt Shanyou63 (Bt-SY63) and its nontransgenic counterpart Shanyou63 (SY63), the leaf gas exchange, yield, grain elements, and antioxidant enzymes were investigated by performing a pot experiment under ambient O3 concentration...
Wed Feb 08, 2017 01:52
The interaction between the CD40 receptor on antigen-presenting cells (APCs) and its trimeric ligand on CD4 T cells is essential for the initiation and progression of the adaptive immune response. Here we undertook to endow CD40 with the capacity to trigger spontaneous APC activation through ligand-independent...
Tue Feb 07, 2017 23:40
Abstract Purpose Patients with familial hyperparathyroidism and low urinary calcium excretion may have familial hypocalciuric hypercalcemia (FHH) with mutations in one of three genes: the calcium-sensing receptor (CaSR) defining FHH-type 1, the adaptor-related protein complex 2 (AP2S1) related to FHH-type...
Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480
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