Cetuximab activity in dysplastic lesions of the upper aerodigestive tract.
Cetuximab activity in dysplastic lesions of the upper aerodigestive tract.: *Cetuximab activity in dysplastic lesions of the upper aerodigestive tract.* Oral Oncol. 2015 Dec ; Authors: Khan Z, Epstein JB, Marur S, Gillespie MB, Feldman L, Tsai HL, Zhang Z, Wang H, Sciubba J, Ferris R, Grandis JR, Gibson M, Koch W, Tufano R, Westra W, Tsottles N, Ozawa H, Chung C, Califano JA Abstract BACKGROUND: High risk head and neck mucosal premalignancy has a malignant conversion rate of up to 40%, despite adequate surgical therapy. Epidermal Growth Factor Receptor (EGFR) blocking agents, incl... περισσότερα »
Regulatory effects of WRAP53 on radiosensitivity of laryngeal squamous cell carcinoma cells.
Regulatory effects of WRAP53 on radiosensitivity of laryngeal squamous cell carcinoma cells.: Related Articles*Regulatory effects of WRAP53 on radiosensitivity of laryngeal squamous cell carcinoma cells.* Asian Pac J Cancer Prev. 2015;16(7):2975-9 Authors: Qiu H, Zhao DY, Yuan LM, Zhang G, Xie CH Abstract BACKGROUND: Telomere length is closely associated with cellular radiosensitivity and WRAP53 is required for telomere addition by telomerase. In this research we assessed radiosensitivity of laryngeal squamous cell carcinoma Hep-2 cell lines after WRAP53 inhibition, and analyzed... περισσότερα »
Biopsy and Resection Specimen in Early Stage Oral Squamous Cell Carcinoma
Poor Correlation of Histologic Parameters Between Biopsy and Resection Specimen in Early Stage Oral Squamous Cell Carcinoma.: [image: http:--highwire.stanford.edu-icons-exter] Am J Clin Pathol. 2015 ;144(4):659-66 Authors: Dik EA, Ipenburg NA, Adriaansens SO, Kessler PA, van Es RJ, Willems SM Abstract OBJECTIVES: Infiltration depth, perineural growth (PG), vascular invasive growth (VG), and infiltrative growth (IG) are associated with regional metastases in oral squamous cell carcinomas (OSCCs). Preoperative knowledge of these parameters could facilitate the treatment planning of... περισσότερα »
The effect of catalase on smoking related laryngeal squamous cell carcinoma
[The effect of catalase on smoking related laryngeal squamous cell carcinoma].: *[The effect of catalase on smoking related laryngeal squamous cell carcinoma].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015;29(15):1346-9 Authors: Liu Y, La C, Wei J, Liu Y, Xu G, Lin Y Abstract OBJECTIVE: Investigate the effect of oxidative stress on the occurrence and development of laryngeal squamous cell carcinoma associated with smoking, and the clinical diagnostic value of catalase on smoking related laryngeal squamous cell carcinoma. METHOD: Collecting 119 smokers(including the smoki...περισσότερα »
Weekly response assessment of involved lymph nodes to radiotherapy using diffusion-weighted MRI in oropharynx squamous cell carcinoma
Weekly response assessment of involved lymph nodes to radiotherapy using diffusion-weighted MRI in oropharynx squamous cell carcinoma: Purpose: Patients with cancers of oropharynx have a favorable prognosis and are an ideal candidate for adaptive therapy. A replan to improve coverage or escalate/de-escalate dose based on morphological information alone may not be adequate as the grossly involved lymph nodes (LNs) of a subset of these patients tend to become cystic and often do not regress. Functional adaptation may be a better approach when considering replanning for these patien... περισσότερα »
The XPD and XRCC3 gene Polymorphisms with Oral Squamous Cell Carcinoma
Association of the XPD and XRCC3 gene Polymorphisms with Oral Squamous Cell Carcinoma in a Northeastern Brazilian Population: A Pilot Study via Oral Biology Publication date: Available online 22 December 2015 *Source:*Archives of Oral Biology Author(s): Joabe dos Santos Pereira, Fabrícia Lima Fontes, Silvia Regina Batistuzzo de Medeiros, Roseana de Almeida Freitas, Lélia Batista de Souza, Márcia Cristina da Costa Miguel Objectiveto evaluate the association between XPD and XRCC3 polymorphisms and oral squamous cellcarcinoma (OSCC).Designthe sample consisted of 54 cases of OSCC and 40 ca... περισσότερα »
PLGA nanoparticle delivery System for 5-fluorouracil and curcumin on squamous cellcarcinoma
Comparative evaluation of via Oral Biology Publication date: Available online December 2015 *Source:*Archives of Oral Biology Author(s): Shaimaa M. Masloub, Mohamed H. Elmalahy, Dina Sabry, Wael S. Mohamed, Sahar H. Ahmed PurposeThe purpose of this study is to assess the effect of 5-fluorouracil nanoparticles and curcumin naoparticles on cell proliferation and the expression of the apoptotic marker (caspase 3) in squamouscell carcinoma cell line.Material and methodsPLGA 5-fluorouracil nanopartciles and PLGA curcumin nanoparticles were prepared and applied for 24 and 48hours on human ... περισσότερα »
Marked decrease in serum squamous cell carcinoma antigen level after antitumor necrosis factor alpha therapy
Marked decrease in serum squamous cell carcinoma antigen level after antitumor necrosis factor alpha therapy in six cases of severe psoriasis:
Tumor/normal esophagus ratio in 18F-fluorodeoxyglucose positron emission tomography/computed tomography for response and prognosis stratification after neoadjuvant chemotherapy for esophageal squamous cell carcinoma
Tumor/normal esophagus ratio in <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography for response and prognosis stratification after neoadjuvant chemotherapy for esophageal squamous cell carcinoma: Journal of Gastroenterology
Dihydroartemisinin suppresses growth of squamous cell carcinoma A431 cells by targeting the Wnt/β-catenin pathway
Dihydroartemisinin suppresses growth of squamous cell carcinoma A431 cells by targeting the Wnt/β-catenin pathway: [image: image]The antimalarial effects of dihydroartemisinin (DHA) have been well documented. However, its potential against skin cancer has not been explored as yet. Therefore, we assessed the function of DHA as an inhibitory factor of squamous cell carcinoma in A431 cells and the underlying mechanism was explored. After stimulation of A431 cells and Hacat cells (normal human keratinocyte cells, as control) with various doses of DHA, the 3-(4,5-dimethyl-2-thiazolyl)-2,...περισσότερα »
Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma.
Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma.: *Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma.* Mol Cancer. 2015;14(1):213 Authors: Sun SS, Zhou X, Huang YY, Kong LP, Mei M, Guo WY, Zhao MH, Ren Y, Shen Q, Zhang L Abstract BACKGROUND: Abnormal activation of STAT3 and miR-21 plays a vital role in progression and invasion of solid tumors. The cyclin-dependent kinase 5 (CDK5) is reported to contribute to cancer m... περισσότερα »
Human papillomavirus 16 (HPV16) enhances tumor growth and cancer stemness of HPV-negative oral/oropharyngeal squamous cell carcinoma cells via miR-181 regulation.
Human papillomavirus 16 (HPV16) enhances tumor growth and cancer stemness of HPV-negative oral/oropharyngeal squamous cell carcinoma cells via miR-181 regulation.: *Human papillomavirus 16 (HPV16) enhances tumor growth and cancer stemness of HPV-negative oral/oropharyngeal squamous cell carcinoma cells via miR-181 regulation.* Papillomavirus Res. 2015 Dec;1:116-125 Authors: Lee SH, Lee CR, Rigas NK, Kim RH, Kang MK, Park NH, Shin KH Abstract High-risk human papillomaviruses (e.g., HPV16, HPV18) are closely associated with the development of head and neck cancers including oral/o... περισσότερα »
IKK phosphorylation of NF-κB at serine 536 contributes to acquired cisplatin resistance in head and neck squamous cell cancer.
IKK phosphorylation of NF-κB at serine 536 contributes to acquired cisplatin resistance in head and neck squamous cell cancer.: *IKK phosphorylation of NF-κB at serine 536 contributes to acquired cisplatin resistance in head and neck squamous cell cancer.* Am J Cancer Res. 2015;5(10):3098-110 Authors: Li Z, Yang Z, Lapidus RG, Liu X, Cullen KJ, Dan HC Abstract Current treatment methods for advanced head and neck squamous cell carcinoma (HNSCC) include surgery, radiation therapy and chemotherapy. For recurrent and metastatic HNSCC, cisplatin is the most common treatment option, bu... περισσότερα »
Dual Drug Loaded Nanoliposomal Chemotherapy for Treatment of Head and Neck Squamous Cell Carcinoma.
Dual Drug Loaded Nanoliposomal Chemotherapy: A Promising Strategy for Treatment of Head and Neck Squamous Cell Carcinoma.: *Dual Drug Loaded Nanoliposomal Chemotherapy: A Promising Strategy for Treatment of Head and Neck Squamous Cell Carcinoma.* Eur J Pharm Biopharm. 2015 Dec ; Authors: Mohan A, Narayanan S, Balasubramanian G, Sethuraman S, Krishnan UM Abstract The rising incidence of head and neck cancer and the drawbacks of currently used therapeutic strategies like salvage surgery followed by adjuvant chemo- or radiotherapy have encouraged pursuits for better therapeutic appr... περισσότερα »
Deregulation of paralogous 13 HOX genes in oral squamous cell carcinoma.
Deregulation of paralogous 13 HOX genes in oral squamous cell carcinoma.: *Deregulation of paralogous 13 HOX genes in oral squamous cell carcinoma.* Am J Cancer Res. 2015;5(10):3042-55 Authors: Aquino G, Franco R, Sabatino R, Mantia EL, Scognamiglio G, Collina F, Longo F, Ionna F, Losito NS, Liguori G, Botti G, Cantile M Abstract Many oncogenic drivers related to the pathogenesis of OSCC have identified, but the discovery of new molecular markers for early detection of this cancer, remains one the main goals of clinical research. HOX genes regulate normal embryonic development, ce...περισσότερα »
STAT3 is a key pathway in primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst.
STAT3 is a key pathway in primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst.: *STAT3 is a key pathway in primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst.* Am J Transl Res. 2015;7(10):1860-9 Authors: Zhang L, Liu SL, Ye WM, Zheng J Abstract PURPOSE: Primary intraosseous squamous cell carcinoma (PIOSCC) arising within an odontogenic keratocyst (OKC) is rare malignancy, entailing a poor prognosis for delayed diagnosis. The number of reports concerning this entity is extremely small. The aim of this study is to pre...περισσότερα »
AEG-1 activates Wnt/PCP signaling to promote metastasis in tongue squamous cell carcinoma.
AEG-1 activates Wnt/PCP signaling to promote metastasis in tongue squamous cell carcinoma.: *AEG-1 activates Wnt/PCP signaling to promote metastasis in tongue squamous cell carcinoma.* Oncotarget. 2015 Dec ' Authors: Pan Y, Guo X, Yang Z, Chen S, Lei Y, Lin M, Wang L, Feng C, Ke Z Abstract Despite advances in therapy, survival among patients with locally advanced squamous cell carcinoma of tongue (TSCC) and cervical lymph node metastasis remains dismal. Here, we estimated the functional effect of AEG-1 on TSCC metastasis and explored the molecular mechanism by which AEG-1 stimula... περισσότερα »
Effects of peritumoral nanoconjugated cisplatin on laryngeal cancer stem cells.
Effects of peritumoral nanoconjugated cisplatin on laryngeal cancer stem cells.: *Effects of peritumoral nanoconjugated cisplatin on laryngeal cancer stem cells.* Laryngoscope. 2015 Dec ; Authors: Sim MW, Grogan PT, Subramanian C, Bradford CR, Carey TE, Forrest ML, Prince ME, Cohen MS Abstract OBJECTIVES/HYPOTHESIS: To evaluate the efficacy of peritumoral hyaluronic acid (HA)-cisplatin therapy in a murine model of laryngeal squamous cell carcinoma and to evaluate its effect on cancer stem cells (CSCs). STUDY DESIGN: An orthotopic murine study utilizing University of Michigan sq... περισσότερα »
Probiotic (yogurt) containing Lactobacillus gasseri OLL2716 is effective for preventing Candida albicans-induced mucosal inflammation and proliferation in the forestomach of diabetic rats.
Probiotic (yogurt) containing Lactobacillus gasseri OLL2716 is effective for preventing Candida albicans-induced mucosal inflammation and proliferation in the forestomach of diabetic rats.: *Probiotic (yogurt) containing Lactobacillus gasseri OLL2716 is effective for preventing Candida albicans-induced mucosal inflammation and proliferation in the forestomach of diabetic rats.* Histol Histopathol. 2015 Dec;:11710 Authors: Terayama Y, Matsuura T, Uchida M, Narama I, Ozaki K Abstract Oral and esophageal candidiasis sometimes leads to mucosal hyperplasia, and progresses to carcinoma...περισσότερα »
Regional control is preserved after dose de-escalated radiotherapy to involved lymph nodes
in HPV positive oropharyngeal cancer via ScienceDirect Publication: Oral Oncology Publication date: Available online December 2015 *Source:*Oral Oncology Author(s): Neil M. Woody, Shlomo A. Koyfman, Ping Xia, Naichang Yu, Qingyang Shang, David J. Adelstein, Joseph Scharpf, Brian Burkey, Tobenna Nwizu, Jerold Saxton, John F. Greskovich ObjectivesTo analyze a cohort of patients with HPV positive, oropharyngeal squamous cell carcinoma(OPSCC) treated with lower radiation dose to clinically involved lymph nodes.Materials and methodsWe retrospectively identified patients with HPV positive, ... περισσότερα »
Elevated Level of Circulating Platelet-derived Microparticles in Oral Cancer
Elevated Level of Circulating Platelet-derived Microparticles in Oral Cancer: Numerous studies have demonstrated that circulating microparticles (MPs) play important roles in a variety of diseases (e.g., atherosclerosis, hypertension, and diabetes), but the association between circulating MPs and oral squamous cell carcinoma (OSCC) remains largely unknown. In the present study, the circulating platelet-derived MPs (PMPs) in 63 patients with OSCC, 22 patients with infected keratocystic odontogenic tumor, and 31 healthy volunteers were characterized and quantified by flow cytometric ...περισσότερα »
Reaction After Cetuximab Treatment
Reaction After Cetuximab Treatment in an Immunocompromised Transplant Patient: This case report describes an inflammatory skin reaction after cetuximab treatment for aggressive cutaneous squamous cell carcinoma in a heart transplant patient previously taking voriconazole. [image: First page PDF preview]
Tumor budding and laminin5-γ2 in squamous cell carcinoma of the external auditory canal
Tumor budding and laminin5-γ2 in squamous cell carcinoma of the external auditory canal are associated with shorter survival: Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is rare, usually presents at an advanced stage, and is a more aggressive tumor with poor prognosis. The University of Pittsburgh TNM staging system commonly used in prognostication is not perfect, and more accurate biomarkers predicting prognosis are needed. Tumor budding is an established negative prognostic factor at the invasive front in colorectal cancer. Moreover, immunohistochemical stud...περισσότερα »
Scapula osteomyocutaneous flap in the repair of maxillary defect
[Application of scapula osteomyocutaneous flap in the repair of maxillary defect].: *[Application of scapula osteomyocutaneous flap in the repair of maxillary defect].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015;50(10):814-7 Authors: Wu Y, Li D, Wang X, Xu Z Abstract OBJECTIVE: Preliminary study on free scapula osteomyocutaneous flap to repair maxillary defect. METHODS: Central maxillofacial soft and hard tissue defect after nasal sinus or oral tumor surgery was repaired with free scapual osteomyocutaneous flap in 4 patients to reconstruct their maxillofacial functions... περισσότερα »
Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma.
Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma.: *Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma.* PLoS One. 2015;10(12):e0144924 Authors: Janiszewska J, Szaumkessel M, Kostrzewska-Poczekaj M, Bednarek K, Paczkowska J, Jackowska J, Grenman R, Szyfter K, Wierzbicka M, Giefing M, Jarmuz-Szymczak M Abstract BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) is the most common group among head and neck cancers. LSCC is characterized by a high incidence in Europe. With ... περισσότερα »
MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma.
MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma.: *MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma.* Int J Mol Sci. 2015;16(12):30204-22 Authors: Sass S, Pitea A, Unger K, Hess J, Mueller NS, Theis FJ Abstract MicroRNAs represent ~22 nt long endogenous small RNA molecules that have been experimentally shown to regulate gene expression post-tra... περισσότερα »
EGFR in Oral Potentially Malignant Disorders: Oral Leukoplakia and Oral Submucous Fibrosis.
Quantitative Immunoexpression of EGFR in Oral Potentially Malignant Disorders: Oral Leukoplakia and Oral Submucous Fibrosis.: *Quantitative Immunoexpression of EGFR in Oral Potentially Malignant Disorders: Oral Leukoplakia and Oral Submucous Fibrosis.* J Dent Res Dent Clin Dent Prospects. 2015;9(3):166-74 Authors: Jyothi Meka N, Ugrappa S, Velpula N, Kumar S, Naik Maloth K, Kodangal S, Ch L, Goyal S Abstract Background and aims. Many oral squamous cell carcinomas develop from potentially malignant disorders (PMDs)which include a variety of lesions and conditions characterized by ... περισσότερα »
Afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV-negative or high-risk HPV-positive locally advanced stage III/IVa/IVb head and neck squamous cell carcinoma.
A phase I study afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV-negative or high-risk HPV-positive locally advanced stage III/IVa/IVb head and neck squamous cell carcinoma.: *A phase I study afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV-negative or high-risk HPV-positive locally advanced stage III/IVa/IVb head and neck squamous cell carcinoma.* Oral Oncol. 2015 Dec ; Authors: Chung CH, Rudek MA, Kang H, Marur S, John P, Tsottles N, Bonerigo S, Veasey A, Kiess A, Quon H, Cmelak A,...περισσότερα »
Cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma.
A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma.: *A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma.* Oral Oncol. 2015 Dec ; Authors: Bowles DW, Keysar SB, Eagles JR, Wang G, Glogowska MJ, McDermott JD, Le PN, Gao D, Ray CE, Rochon PJ, Roop DR, Tan AC, Serracino HS, Jimeno A Abstract BACKGROUND: This phase 1, dose-finding study determined the safety, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), antitumor activity, ... περισσότερα »
Anti-EGFR monoclonal antibodies in recurrent and/or metastatic HNSCC
[Anti-EGFR monoclonal antibodies in recurrent and/or metastatic head and neck squamous cell carcinoma: a meta-analysis].: *[Anti-EGFR monoclonal antibodies in recurrent and/or metastatic head and neck squamous cell carcinoma: a meta-analysis].* Zhonghua Yi Xue Za Zhi. 2015;95(22):1779-1783 Authors: Song Q, Li X, Li B, Di B, Xiao S Abstract OBJECTIVE: To systematically review the literature regarding the effectiveness and adverse reaction of epidermal growth factor receptor-monoclonal antibodies (RGFR-mAbs) in improving the prognosis of R/M HNSCC so as to develop evidence-based re... περισσότερα »
MicroR-140-5p suppresses tumor cell migration and invasion by targeting ADAM10-mediated Notch1 signaling pathway in hypopharyngeal squamous cell carcinoma.
MicroR-140-5p suppresses tumor cell migration and invasion by targeting ADAM10-mediated Notch1 signaling pathway in hypopharyngeal squamous cell carcinoma.: *MicroR-140-5p suppresses tumor cell migration and invasion by targeting ADAM10-mediated Notch1 signaling pathway in hypopharyngeal squamous cell carcinoma.* Exp Mol Pathol. 2015 Dec 15; Authors: Jing P, Sa N, Liu X, Liu X, Xu W Abstract MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides that negatively regulate gene expression at the post-transcriptional level. Downexpression of miR-140-5p was repo... περισσότερα »
Total rhinectomy
Total rhinectomy, a clinical review of nine cases.: *Total rhinectomy, a clinical review of nine cases.* Ir J Med Sci. 2015 Dec 24; Authors: Subramaniam T, Lennon P, O'Neill JP, Kinsella J, Timon C Abstract INTRODUCTION: A large proportion of malignancies involving the external nose can be managed with limited resection and local autologous reconstruction or, in some cases, radiotherapy as primary or adjuvant treatment. We highlight a small cohort of patients undergoing total rhinectomy for advanced nasal malignancies. METHODS: A retrospective review of all patients undergoing to... περισσότερα »
Proton beam therapy combined with weekly cisplatin intra-arterial infusion via a superficial temporal artery for treatment of maxillary sinus carcinoma
Preliminary results of proton beam therapy combined with weekly cisplatin intra-arterial infusion via a superficial temporal artery for treatment of maxillary sinus carcinoma: Objective This study aimed to evaluate the efficacy and toxicity of proton beam therapy combined with cisplatin intra-arterial infusion via a superficial temporal artery as treatment for maxillary sinus carcinoma. Methods Twenty-six patients with confirmed maxillary sinus carcinoma were enrolled in this study from May 2009 to April 2011. Patients underwent proton beam therapy and intra-arterial infusion chemo... περισσότερα »
Clinical results of definitive intensity-modulated radiation therapy for oropharyngeal cancer: retrospective analysis of treatment efficacy and safety
Clinical results of definitive intensity-modulated radiation therapy for oropharyngeal cancer: retrospective analysis of treatment efficacy and safety: Objective To evaluate the clinical outcomes of intensity-modulated radiotherapy for patients with oropharyngeal carcinoma. Methods Ninety-three oropharyngeal carcinoma patients histopathologically diagnosed with squamous cell carcinoma and treated with definitive intensity-modulated radiotherapy using helical tomotherapy between January 2006 and December 2013 were analyzed. Planning target volume primary and involved nodes was deli...περισσότερα »
Locally advanced hypopharyngeal and oropharyngeal cancer treated with definitive concurrent chemoradiotherapy
Different clinical outcomes between locally advanced hypopharyngeal and oropharyngeal cancer treated with definitive concurrent chemoradiotherapy: implication for subgroup selection for induction chemotherapy: Objective The purpose of this study is to compare the long-term clinical outcome of hypopharynx cancer and oropharynx cancer treated with concurrent chemoradiotherapy. Methods A total of 213 patients with locally advanced hypopharyngeal squamous cell carcinoma (*n* = 79) or oropharygeal squamous cell carcinoma (*n* = 134) were included. All patients were treated with upfront ...περισσότερα »
Nasal cavity ventilation expansion techniques
Effects of nasal cavity ventilation expansion techniques on airflow patterns of the upper airway *Author(s):* ZANG Hongrui, LI Lifeng, ZHANG Luo, ZHOU Bing, LI Yunchuan, CUI Shunjiu, HUANG Qian, WANG Tong, HAN Demin,Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education *Pages:* 548-553 *Year:* 2015 *Issue:* 11 *Journal:* *Chinese Archives of Otolaryngology-Head and Neck Surgery* *Keyword:* Sleep Apnea; Obstructive; Surgical Procedures; Operative; nasal ca... περισσότερα »
Intranasal airflow field
Numerical simulation of intranasal airflow field *Author(s):* SU Yingfeng, LIU Yingxi, SUN Xiuzhen, YU Shen, WANG Jizhe, State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanicals, Dalian University of Technology, Department of Otolaryngology, the Second Affiliated Hospital of Dalian Medical University *Pages:* 545-547+562 *Year:* 2015 *Issue:* 11 *Journal:* *Chinese Archives of Otolaryngology-Head and Neck Surgery* *Keyword:* Numerical Analysis; Computer-Assisted Nasal Cavity; aerodynamics ; *Abstract:* OBJECTIVE To explore the basic c...περισσότερα »
Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma.
Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma.: *Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma.* Head Neck. 2015 Dec 26; Authors: Wong BY, Stafford ND, Green VL, Greenman J Abstract BACKGROUND: The neutrophil/lymphocyte ratio (NLR) has been found to be predictive of survival outcome in a range of tumors. The purpose of this study was to investigate the prognostic value of pretreatment (NLR) in patients with laryngeal squamous cell carcinoma (SCC). METHODS: A re...περισσότερα »
The STAT3 pathway as a therapeutic target in head and neck cancer
The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations: Proteins of the signal transducer and activator of transcription (STAT) family mediate cellular responses to cytokines and growth factors. Aberrant regulation of the STAT3 oncogene contributes to tumor formation and progression in many cancers, including head and neck squamous cell carcinoma (HNSCC), where hyperactivation of STAT3 is implicated in both treatment resistance and immune escape. There are no oncogenic gain-of-function mutations in HNSCC. Rather, aberrant STAT3 signaling is prima...περισσότερα »
Pseudocarcinomatous Hyperplasia Hiding Lymphomatoid Papulosis
Pseudocarcinomatous Hyperplasia Hiding Lymphomatoid Papulosis: A "Low-Power View" Pitfall: Pseudocarcinomatous hyperplasia (PCH) is a reactive proliferation of the epidermis that can be associated with many inflammatory and neoplastic conditions. Histologically, it is characterized by irregular strands of epidermis, usually at the level of the follicular infundibulum, projecting downward into the dermis. The differentiation between a well-differentiated squamous cell carcinoma and PCH can be particularly challenging when the biopsy is superficial and the causing lesion is dermal-ba... περισσότερα »
Lymphoepithelioma-like Carcinoma of the Skin with Perineural Invasion
Lymphoepithelioma-like Carcinoma of the Skin: A Case with Perineural Invasion: Summary: Lymphoepithelioma-like carcinoma of the skin is a rare, low malignant cutaneous neoplasm. We report a case of an elderly woman with lymphoepithelioma-like carcinoma of the skin in the forehead. The tumor was mistaken first as actinic keratosis and later as metastatic squamous cell carcinoma. A histological reassessment showed lymphoepithelioma-like carcinoma of the skin with perineural invasion, which is rare and considered more aggressive. The patient therefore received adjuvant radiotherapy aft... περισσότερα »
