Association between glutathione S-transferases M1, T1 and P1 gene polymorphisms and prostate cancer in Koreans
Abstract Prostate cancer (PCa) is the most commonly diagnosed cancer in the developed world, and the incidence of this cancer is rising rapidly in many countries. Several polymorphic genes encoding enzymes involved carcinogenesis have been studied as potential risk factor of prostate cancer. Genetic polymorphisms in glutathione S-transferases M1 (*GSTM1*), T1 (*GSTT1*) and P1 (*GSTP1*) genes have been constantly reported to have a meaningful effect on prostate cancer risk. But other surveys of this relationship have yielded inconsistent results. To assess the possible contribution... περισσότερα »
Prospector Michael Graham died – a $300 beacon could have saved him – The Australian Financial Review
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Prospector Michael Graham died – a $300 beacon could have saved him The Australian Financial Review On Sunday, Graham searches for some flowers he thinks may be a cure for cancer – he has a degenerative back condition he believes could turn cancerous – and the pair begin examining rocks for gold. Holloway wakes about […]
Highlights: Volume 231, Number 4
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Editor’s Choice
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Withdrawal Statement: Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages by Huwait, E.A., Singh, N.N., Michael, D.R., Davies, T.S., Moss, J.W.E., and Ramji, D.P.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
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Spatial variation in osteon population density at the human femoral midshaft: histomorphometric adaptations to habitual load environment
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Abstract Intracortical remodeling, and the osteons it produces, is one aspect of the bone microstructure that is influenced by and, in turn, can influence its mechanical properties. Previous research examining the spatial distribution of intracortical remodeling density across the femoral midshaft has been limited to either considering only small regions of the cortex or, when […]
The XPD and XRCC3 gene Polymorphisms with Oral Squamous Cell Carcinoma
Association of the XPD and XRCC3 gene Polymorphisms with Oral Squamous Cell Carcinoma in a Northeastern Brazilian Population: A Pilot Study via Oral Biology Publication date: Available online 22 December 2015 *Source:*Archives of Oral Biology Author(s): Joabe dos Santos Pereira, Fabrícia Lima Fontes, Silvia Regina Batistuzzo de Medeiros, Roseana de Almeida Freitas, Lélia Batista de Souza, Márcia Cristina da Costa Miguel Objectiveto evaluate the association between XPD and XRCC3 polymorphisms and oral squamous cellcarcinoma (OSCC).Designthe sample consisted of 54 cases of OSCC and 40 ca... περισσότερα »
Behavior of melanocytes and keratinocytes in reticulate acropigmentation of Kitamura
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Abstract Reticulate acropigmentation of Kitamura (RAK, OMIM 615537) is a rare genetic pigmentary disorder that usually shows an autosomal dominant pattern of inheritance with high penetrance. The disorder was first described by Kitamura and Akamatsu in 1943, and then reported worldwide in 1953 (Kitamura et al., 1953). RAK patients typically present within the first or […]
Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 4 δευτερόλεπτα
Abstract Immune-mediated diseases are common and life-threatening disorders in dogs. Many canine immune-mediated diseases have strong breed predispositions and are believed to be inherited. However, the genetic mutations that cause these diseases are mostly unknown. As many immune-mediated diseases in humans share polymorphisms among a common set of genes, we conducted a candidate gene study […]
A longitudinal study of changing characteristics of self-reported taste and smell alterations in patients treated for lung cancer.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 4 δευτερόλεπτα
CONCLUSIONS: Our results suggest that healthcare professionals need to consider the variation in characteristics of TSAs among and within patients over time, and be attentive to individual experiences of TSAs. PMID: 26706824 [PubMed – as supplied by publisher] (Source: European Journal of Oncology Nursing) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1VmivKr via IFTTT
Information needs of cancer patients: Validation of the Greek Cassileth’s Information Styles Questionnaire.
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CONCLUSIONS: The results showed that the Greek ISQ is a reliable and valid tool for identifying the information needs of cancer patients. PMID: 26700140 [PubMed – as supplied by publisher] (Source: European Journal of Oncology Nursing) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1VmivKj via IFTTT
Toxins, Vol. 8, Pages 5: Development of an Enzyme-Linked Immunosorbent Assay Method Specific for the Detection of G-Group Aflatoxins
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 4 δευτερόλεπτα
To detect and monitor G-group aflatoxins in agricultural products, we generated class-specific monoclonal antibodies that specifically recognized aflatoxins G1 and G2. Of the final three positive and stable hybridomas obtained, clone 2G6 produced a monoclonal antibody that had equal sensitivity to aflatoxins G1 and G2, and did not cross-react with aflatoxins B1, B2, or M1. […]
Highlights: Volume 231, Number 4
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Editor’s Choice
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Withdrawal Statement: Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages by Huwait, E.A., Singh, N.N., Michael, D.R., Davies, T.S., Moss, J.W.E., and Ramji, D.P.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 4 δευτερόλεπτα
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Table of Contents: Volume 231, Number 4
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 4 δευτερόλεπτα
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The choice dilemma in chronic hematological conditions: Why choosing is not only a medical issue? A psycho-cognitive perspective
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 4 δευτερόλεπτα
Research in cognitive psychology focused on risk perception and decision making was shown to facilitate treatment choice and patient’s satisfaction with decision in a number of medical conditions, increasing perceived alliance between patient and physician, and adherence to treatment. However, this aspect has been mostly neglected in the literature investigating choice of treatment for chronic […]
Psychosocial Palliative Care By William S. Breitbart and Yesne Alici. Oxford University Press, New York, 2014, 192 pages, ISBN: 9780199917402, Cost £32.99
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 4 δευτερόλεπτα
(Source: Psycho-Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Ps7C7y via IFTTT
PLGA nanoparticle delivery System for 5-fluorouracil and curcumin on squamous cellcarcinoma
Comparative evaluation of via Oral Biology Publication date: Available online December 2015 *Source:*Archives of Oral Biology Author(s): Shaimaa M. Masloub, Mohamed H. Elmalahy, Dina Sabry, Wael S. Mohamed, Sahar H. Ahmed PurposeThe purpose of this study is to assess the effect of 5-fluorouracil nanoparticles and curcumin naoparticles on cell proliferation and the expression of the apoptotic marker (caspase 3) in squamouscell carcinoma cell line.Material and methodsPLGA 5-fluorouracil nanopartciles and PLGA curcumin nanoparticles were prepared and applied for 24 and 48hours on human ... περισσότερα »
Marked decrease in serum squamous cell carcinoma antigen level after antitumor necrosis factor alpha therapy
Marked decrease in serum squamous cell carcinoma antigen level after antitumor necrosis factor alpha therapy in six cases of severe psoriasis:
Tumor/normal esophagus ratio in 18F-fluorodeoxyglucose positron emission tomography/computed tomography for response and prognosis stratification after neoadjuvant chemotherapy for esophageal squamous cell carcinoma
Tumor/normal esophagus ratio in <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography for response and prognosis stratification after neoadjuvant chemotherapy for esophageal squamous cell carcinoma: Journal of Gastroenterology
Dihydroartemisinin suppresses growth of squamous cell carcinoma A431 cells by targeting the Wnt/β-catenin pathway
Dihydroartemisinin suppresses growth of squamous cell carcinoma A431 cells by targeting the Wnt/β-catenin pathway: [image: image]The antimalarial effects of dihydroartemisinin (DHA) have been well documented. However, its potential against skin cancer has not been explored as yet. Therefore, we assessed the function of DHA as an inhibitory factor of squamous cell carcinoma in A431 cells and the underlying mechanism was explored. After stimulation of A431 cells and Hacat cells (normal human keratinocyte cells, as control) with various doses of DHA, the 3-(4,5-dimethyl-2-thiazolyl)-2,...περισσότερα »
Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma.
Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma.: *Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma.* Mol Cancer. 2015;14(1):213 Authors: Sun SS, Zhou X, Huang YY, Kong LP, Mei M, Guo WY, Zhao MH, Ren Y, Shen Q, Zhang L Abstract BACKGROUND: Abnormal activation of STAT3 and miR-21 plays a vital role in progression and invasion of solid tumors. The cyclin-dependent kinase 5 (CDK5) is reported to contribute to cancer m... περισσότερα »
Human papillomavirus 16 (HPV16) enhances tumor growth and cancer stemness of HPV-negative oral/oropharyngeal squamous cell carcinoma cells via miR-181 regulation.
Human papillomavirus 16 (HPV16) enhances tumor growth and cancer stemness of HPV-negative oral/oropharyngeal squamous cell carcinoma cells via miR-181 regulation.: *Human papillomavirus 16 (HPV16) enhances tumor growth and cancer stemness of HPV-negative oral/oropharyngeal squamous cell carcinoma cells via miR-181 regulation.* Papillomavirus Res. 2015 Dec;1:116-125 Authors: Lee SH, Lee CR, Rigas NK, Kim RH, Kang MK, Park NH, Shin KH Abstract High-risk human papillomaviruses (e.g., HPV16, HPV18) are closely associated with the development of head and neck cancers including oral/o... περισσότερα »
IKK phosphorylation of NF-κB at serine 536 contributes to acquired cisplatin resistance in head and neck squamous cell cancer.
IKK phosphorylation of NF-κB at serine 536 contributes to acquired cisplatin resistance in head and neck squamous cell cancer.: *IKK phosphorylation of NF-κB at serine 536 contributes to acquired cisplatin resistance in head and neck squamous cell cancer.* Am J Cancer Res. 2015;5(10):3098-110 Authors: Li Z, Yang Z, Lapidus RG, Liu X, Cullen KJ, Dan HC Abstract Current treatment methods for advanced head and neck squamous cell carcinoma (HNSCC) include surgery, radiation therapy and chemotherapy. For recurrent and metastatic HNSCC, cisplatin is the most common treatment option, bu... περισσότερα »
Dual Drug Loaded Nanoliposomal Chemotherapy for Treatment of Head and Neck Squamous Cell Carcinoma.
Dual Drug Loaded Nanoliposomal Chemotherapy: A Promising Strategy for Treatment of Head and Neck Squamous Cell Carcinoma.: *Dual Drug Loaded Nanoliposomal Chemotherapy: A Promising Strategy for Treatment of Head and Neck Squamous Cell Carcinoma.* Eur J Pharm Biopharm. 2015 Dec ; Authors: Mohan A, Narayanan S, Balasubramanian G, Sethuraman S, Krishnan UM Abstract The rising incidence of head and neck cancer and the drawbacks of currently used therapeutic strategies like salvage surgery followed by adjuvant chemo- or radiotherapy have encouraged pursuits for better therapeutic appr... περισσότερα »
Deregulation of paralogous 13 HOX genes in oral squamous cell carcinoma.
Deregulation of paralogous 13 HOX genes in oral squamous cell carcinoma.: *Deregulation of paralogous 13 HOX genes in oral squamous cell carcinoma.* Am J Cancer Res. 2015;5(10):3042-55 Authors: Aquino G, Franco R, Sabatino R, Mantia EL, Scognamiglio G, Collina F, Longo F, Ionna F, Losito NS, Liguori G, Botti G, Cantile M Abstract Many oncogenic drivers related to the pathogenesis of OSCC have identified, but the discovery of new molecular markers for early detection of this cancer, remains one the main goals of clinical research. HOX genes regulate normal embryonic development, ce...περισσότερα »
STAT3 is a key pathway in primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst.
STAT3 is a key pathway in primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst.: *STAT3 is a key pathway in primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst.* Am J Transl Res. 2015;7(10):1860-9 Authors: Zhang L, Liu SL, Ye WM, Zheng J Abstract PURPOSE: Primary intraosseous squamous cell carcinoma (PIOSCC) arising within an odontogenic keratocyst (OKC) is rare malignancy, entailing a poor prognosis for delayed diagnosis. The number of reports concerning this entity is extremely small. The aim of this study is to pre...περισσότερα »
Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis
Summary Wnt5a-Ror2 signaling has been shown to play important roles in promoting aggressiveness of various cancer cells in a cell-autonomous manner. However, little is known about its function in cancer-associated stromal cells, including mesenchymal stem cells (MSCs). Thus, we examined the role of Wnt5a-Ror2 signaling in bone marrow-derived MSCs in regulating proliferation of undifferentiated gastric cancer cells. Co-culture of a gastric cancer cell line, MKN45 cells, with MSCs either directly or indirectly promotes proliferation of MKN45 cells, and suppressed expression of *Ror2... περισσότερα »
FOXA1 expression affects to the proliferation activity of luminal breast cancer stem cell populations
Abstract The expression of estrogen receptor (ER) is the key in most breast cancers (BC) and binding of ER to the genome correlates to Forkhead protein (FOXA1) expression. We herein assessed the correlation between the cancer stem cell (CSC) population and FOXA1 expression in luminal breast cancer (BC). We established luminal BC cells derived from metastatic pleural effusion and analyzed the potency of CSC and related factors with established luminal BC cell lines. We also confirmed that mammosphere cultures have an increased aldehyde dehydrogenase (ALDH)-positive population, which...περισσότερα »
AEG-1 activates Wnt/PCP signaling to promote metastasis in tongue squamous cell carcinoma.
AEG-1 activates Wnt/PCP signaling to promote metastasis in tongue squamous cell carcinoma.: *AEG-1 activates Wnt/PCP signaling to promote metastasis in tongue squamous cell carcinoma.* Oncotarget. 2015 Dec ' Authors: Pan Y, Guo X, Yang Z, Chen S, Lei Y, Lin M, Wang L, Feng C, Ke Z Abstract Despite advances in therapy, survival among patients with locally advanced squamous cell carcinoma of tongue (TSCC) and cervical lymph node metastasis remains dismal. Here, we estimated the functional effect of AEG-1 on TSCC metastasis and explored the molecular mechanism by which AEG-1 stimula... περισσότερα »
Effects of peritumoral nanoconjugated cisplatin on laryngeal cancer stem cells.
Effects of peritumoral nanoconjugated cisplatin on laryngeal cancer stem cells.: *Effects of peritumoral nanoconjugated cisplatin on laryngeal cancer stem cells.* Laryngoscope. 2015 Dec ; Authors: Sim MW, Grogan PT, Subramanian C, Bradford CR, Carey TE, Forrest ML, Prince ME, Cohen MS Abstract OBJECTIVES/HYPOTHESIS: To evaluate the efficacy of peritumoral hyaluronic acid (HA)-cisplatin therapy in a murine model of laryngeal squamous cell carcinoma and to evaluate its effect on cancer stem cells (CSCs). STUDY DESIGN: An orthotopic murine study utilizing University of Michigan sq... περισσότερα »
Probiotic (yogurt) containing Lactobacillus gasseri OLL2716 is effective for preventing Candida albicans-induced mucosal inflammation and proliferation in the forestomach of diabetic rats.
Probiotic (yogurt) containing Lactobacillus gasseri OLL2716 is effective for preventing Candida albicans-induced mucosal inflammation and proliferation in the forestomach of diabetic rats.: *Probiotic (yogurt) containing Lactobacillus gasseri OLL2716 is effective for preventing Candida albicans-induced mucosal inflammation and proliferation in the forestomach of diabetic rats.* Histol Histopathol. 2015 Dec;:11710 Authors: Terayama Y, Matsuura T, Uchida M, Narama I, Ozaki K Abstract Oral and esophageal candidiasis sometimes leads to mucosal hyperplasia, and progresses to carcinoma...περισσότερα »
Regional control is preserved after dose de-escalated radiotherapy to involved lymph nodes
in HPV positive oropharyngeal cancer via ScienceDirect Publication: Oral Oncology Publication date: Available online December 2015 *Source:*Oral Oncology Author(s): Neil M. Woody, Shlomo A. Koyfman, Ping Xia, Naichang Yu, Qingyang Shang, David J. Adelstein, Joseph Scharpf, Brian Burkey, Tobenna Nwizu, Jerold Saxton, John F. Greskovich ObjectivesTo analyze a cohort of patients with HPV positive, oropharyngeal squamous cell carcinoma(OPSCC) treated with lower radiation dose to clinically involved lymph nodes.Materials and methodsWe retrospectively identified patients with HPV positive, ... περισσότερα »
Elevated Level of Circulating Platelet-derived Microparticles in Oral Cancer
Elevated Level of Circulating Platelet-derived Microparticles in Oral Cancer: Numerous studies have demonstrated that circulating microparticles (MPs) play important roles in a variety of diseases (e.g., atherosclerosis, hypertension, and diabetes), but the association between circulating MPs and oral squamous cell carcinoma (OSCC) remains largely unknown. In the present study, the circulating platelet-derived MPs (PMPs) in 63 patients with OSCC, 22 patients with infected keratocystic odontogenic tumor, and 31 healthy volunteers were characterized and quantified by flow cytometric ...περισσότερα »
Reaction After Cetuximab Treatment
Reaction After Cetuximab Treatment in an Immunocompromised Transplant Patient: This case report describes an inflammatory skin reaction after cetuximab treatment for aggressive cutaneous squamous cell carcinoma in a heart transplant patient previously taking voriconazole. [image: First page PDF preview]
Tumor budding and laminin5-γ2 in squamous cell carcinoma of the external auditory canal
Tumor budding and laminin5-γ2 in squamous cell carcinoma of the external auditory canal are associated with shorter survival: Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is rare, usually presents at an advanced stage, and is a more aggressive tumor with poor prognosis. The University of Pittsburgh TNM staging system commonly used in prognostication is not perfect, and more accurate biomarkers predicting prognosis are needed. Tumor budding is an established negative prognostic factor at the invasive front in colorectal cancer. Moreover, immunohistochemical stud...περισσότερα »
Scapula osteomyocutaneous flap in the repair of maxillary defect
[Application of scapula osteomyocutaneous flap in the repair of maxillary defect].: *[Application of scapula osteomyocutaneous flap in the repair of maxillary defect].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015;50(10):814-7 Authors: Wu Y, Li D, Wang X, Xu Z Abstract OBJECTIVE: Preliminary study on free scapula osteomyocutaneous flap to repair maxillary defect. METHODS: Central maxillofacial soft and hard tissue defect after nasal sinus or oral tumor surgery was repaired with free scapual osteomyocutaneous flap in 4 patients to reconstruct their maxillofacial functions... περισσότερα »
Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma.
Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma.: *Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma.* PLoS One. 2015;10(12):e0144924 Authors: Janiszewska J, Szaumkessel M, Kostrzewska-Poczekaj M, Bednarek K, Paczkowska J, Jackowska J, Grenman R, Szyfter K, Wierzbicka M, Giefing M, Jarmuz-Szymczak M Abstract BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) is the most common group among head and neck cancers. LSCC is characterized by a high incidence in Europe. With ... περισσότερα »
MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma.
MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma.: *MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma.* Int J Mol Sci. 2015;16(12):30204-22 Authors: Sass S, Pitea A, Unger K, Hess J, Mueller NS, Theis FJ Abstract MicroRNAs represent ~22 nt long endogenous small RNA molecules that have been experimentally shown to regulate gene expression post-tra... περισσότερα »
Information needs of cancer patients: Validation of the Greek Cassileth’s Information Styles Questionnaire.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
CONCLUSIONS: The results showed that the Greek ISQ is a reliable and valid tool for identifying the information needs of cancer patients. PMID: 26700140 [PubMed – as supplied by publisher] (Source: European Journal of Oncology Nursing) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1VmivKj via IFTTT
Toxins, Vol. 8, Pages 5: Development of an Enzyme-Linked Immunosorbent Assay Method Specific for the Detection of G-Group Aflatoxins
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
To detect and monitor G-group aflatoxins in agricultural products, we generated class-specific monoclonal antibodies that specifically recognized aflatoxins G1 and G2. Of the final three positive and stable hybridomas obtained, clone 2G6 produced a monoclonal antibody that had equal sensitivity to aflatoxins G1 and G2, and did not cross-react with aflatoxins B1, B2, or M1. […]
Highlights: Volume 231, Number 4
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
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Editor’s Choice
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Behavior of melanocytes and keratinocytes in reticulate acropigmentation of Kitamura
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Abstract Reticulate acropigmentation of Kitamura (RAK, OMIM 615537) is a rare genetic pigmentary disorder that usually shows an autosomal dominant pattern of inheritance with high penetrance. The disorder was first described by Kitamura and Akamatsu in 1943, and then reported worldwide in 1953 (Kitamura et al., 1953). RAK patients typically present within the first or […]
Spectrum of EGFR gene mutations in Vietnamese patients with non–small cell lung cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
ConclusionDNA sequencing detected EGFR mutations with high frequency and revealed a broad spectrum of mutation type in Vietnamese patients with NSCLC. (Source: Asia-Pacific Journal of Clinical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OgMMJf via IFTTT
Komplett subkutaner implantierbarer Kardioverter-Defibrillator
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Betreuung während Entbindung Inadäquate Schockabgaben sind bei subkutanen implantierbaren Kardioverter-Defibrillatoren (S-ICDs) ein beschriebenes Problem. Situationen, wie z. B. der Geburtsvorgang, die für inadäquate Schockabgaben prädisponieren, müssen erkannt und die beste Behandlungsstrategie muss gewählt werden. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R3gzWB via IFTTT
Diagnostik und Therapie der Nephrolithiasis: Was ist gesichert?
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Fortbildung Nierensteine sind eine häufige Ursache von Nierenerkrankungen mit meist chronischem Verlauf und hoher Rezidivhäufigkeit. Im folgenden Beitrag werden für den Internisten die diagnostische Herangehensweise beim symptomatischen Nierenstein und die therapeutischen Optionen beleuchtet. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mlXnYp via IFTTT
Ki67—An unsuitable marker of gastric cancer prognosis unmasks intratumoral heterogeneity
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
ConclusionTMAs carry the risk of a systematic underestimation of the Ki67 PI. Ki67 has no prognostic value in GC but might be a potential indicator of intratumoral heterogeneity. J. Surg. Oncol. © 2015 The Authors. Journal of Surgical Oncology published by Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader […]
The importance of surgical margins in retroperitoneal sarcoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Surgery is the “gold‐standard” treatment for retroperitoneal sarcomas, but local recurrence is common, and can cause disease‐related death. Complete gross resection is associated with improved survival, but debate exists as to whether resection of adjacent organs to improve margins or prescription of neoadjuvant radiation leads to better outcomes. This review summarizes data addressing prognostic value […]
EGFR in Oral Potentially Malignant Disorders: Oral Leukoplakia and Oral Submucous Fibrosis.
Quantitative Immunoexpression of EGFR in Oral Potentially Malignant Disorders: Oral Leukoplakia and Oral Submucous Fibrosis.: *Quantitative Immunoexpression of EGFR in Oral Potentially Malignant Disorders: Oral Leukoplakia and Oral Submucous Fibrosis.* J Dent Res Dent Clin Dent Prospects. 2015;9(3):166-74 Authors: Jyothi Meka N, Ugrappa S, Velpula N, Kumar S, Naik Maloth K, Kodangal S, Ch L, Goyal S Abstract Background and aims. Many oral squamous cell carcinomas develop from potentially malignant disorders (PMDs)which include a variety of lesions and conditions characterized by ... περισσότερα »
Afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV-negative or high-risk HPV-positive locally advanced stage III/IVa/IVb head and neck squamous cell carcinoma.
A phase I study afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV-negative or high-risk HPV-positive locally advanced stage III/IVa/IVb head and neck squamous cell carcinoma.: *A phase I study afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV-negative or high-risk HPV-positive locally advanced stage III/IVa/IVb head and neck squamous cell carcinoma.* Oral Oncol. 2015 Dec ; Authors: Chung CH, Rudek MA, Kang H, Marur S, John P, Tsottles N, Bonerigo S, Veasey A, Kiess A, Quon H, Cmelak A,...περισσότερα »
Cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma.
A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma.: *A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma.* Oral Oncol. 2015 Dec ; Authors: Bowles DW, Keysar SB, Eagles JR, Wang G, Glogowska MJ, McDermott JD, Le PN, Gao D, Ray CE, Rochon PJ, Roop DR, Tan AC, Serracino HS, Jimeno A Abstract BACKGROUND: This phase 1, dose-finding study determined the safety, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), antitumor activity, ... περισσότερα »
Anti-EGFR monoclonal antibodies in recurrent and/or metastatic HNSCC
[Anti-EGFR monoclonal antibodies in recurrent and/or metastatic head and neck squamous cell carcinoma: a meta-analysis].: *[Anti-EGFR monoclonal antibodies in recurrent and/or metastatic head and neck squamous cell carcinoma: a meta-analysis].* Zhonghua Yi Xue Za Zhi. 2015;95(22):1779-1783 Authors: Song Q, Li X, Li B, Di B, Xiao S Abstract OBJECTIVE: To systematically review the literature regarding the effectiveness and adverse reaction of epidermal growth factor receptor-monoclonal antibodies (RGFR-mAbs) in improving the prognosis of R/M HNSCC so as to develop evidence-based re... περισσότερα »
MicroR-140-5p suppresses tumor cell migration and invasion by targeting ADAM10-mediated Notch1 signaling pathway in hypopharyngeal squamous cell carcinoma.
MicroR-140-5p suppresses tumor cell migration and invasion by targeting ADAM10-mediated Notch1 signaling pathway in hypopharyngeal squamous cell carcinoma.: *MicroR-140-5p suppresses tumor cell migration and invasion by targeting ADAM10-mediated Notch1 signaling pathway in hypopharyngeal squamous cell carcinoma.* Exp Mol Pathol. 2015 Dec 15; Authors: Jing P, Sa N, Liu X, Liu X, Xu W Abstract MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides that negatively regulate gene expression at the post-transcriptional level. Downexpression of miR-140-5p was repo... περισσότερα »
Total rhinectomy
Total rhinectomy, a clinical review of nine cases.: *Total rhinectomy, a clinical review of nine cases.* Ir J Med Sci. 2015 Dec 24; Authors: Subramaniam T, Lennon P, O'Neill JP, Kinsella J, Timon C Abstract INTRODUCTION: A large proportion of malignancies involving the external nose can be managed with limited resection and local autologous reconstruction or, in some cases, radiotherapy as primary or adjuvant treatment. We highlight a small cohort of patients undergoing total rhinectomy for advanced nasal malignancies. METHODS: A retrospective review of all patients undergoing to... περισσότερα »
Proton beam therapy combined with weekly cisplatin intra-arterial infusion via a superficial temporal artery for treatment of maxillary sinus carcinoma
Preliminary results of proton beam therapy combined with weekly cisplatin intra-arterial infusion via a superficial temporal artery for treatment of maxillary sinus carcinoma: Objective This study aimed to evaluate the efficacy and toxicity of proton beam therapy combined with cisplatin intra-arterial infusion via a superficial temporal artery as treatment for maxillary sinus carcinoma. Methods Twenty-six patients with confirmed maxillary sinus carcinoma were enrolled in this study from May 2009 to April 2011. Patients underwent proton beam therapy and intra-arterial infusion chemo... περισσότερα »
Clinical results of definitive intensity-modulated radiation therapy for oropharyngeal cancer: retrospective analysis of treatment efficacy and safety
Clinical results of definitive intensity-modulated radiation therapy for oropharyngeal cancer: retrospective analysis of treatment efficacy and safety: Objective To evaluate the clinical outcomes of intensity-modulated radiotherapy for patients with oropharyngeal carcinoma. Methods Ninety-three oropharyngeal carcinoma patients histopathologically diagnosed with squamous cell carcinoma and treated with definitive intensity-modulated radiotherapy using helical tomotherapy between January 2006 and December 2013 were analyzed. Planning target volume primary and involved nodes was deli...περισσότερα »
Locally advanced hypopharyngeal and oropharyngeal cancer treated with definitive concurrent chemoradiotherapy
Different clinical outcomes between locally advanced hypopharyngeal and oropharyngeal cancer treated with definitive concurrent chemoradiotherapy: implication for subgroup selection for induction chemotherapy: Objective The purpose of this study is to compare the long-term clinical outcome of hypopharynx cancer and oropharynx cancer treated with concurrent chemoradiotherapy. Methods A total of 213 patients with locally advanced hypopharyngeal squamous cell carcinoma (*n* = 79) or oropharygeal squamous cell carcinoma (*n* = 134) were included. All patients were treated with upfront ...περισσότερα »
Nasal cavity ventilation expansion techniques
Effects of nasal cavity ventilation expansion techniques on airflow patterns of the upper airway *Author(s):* ZANG Hongrui, LI Lifeng, ZHANG Luo, ZHOU Bing, LI Yunchuan, CUI Shunjiu, HUANG Qian, WANG Tong, HAN Demin,Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education *Pages:* 548-553 *Year:* 2015 *Issue:* 11 *Journal:* *Chinese Archives of Otolaryngology-Head and Neck Surgery* *Keyword:* Sleep Apnea; Obstructive; Surgical Procedures; Operative; nasal ca... περισσότερα »
Intranasal airflow field
Numerical simulation of intranasal airflow field *Author(s):* SU Yingfeng, LIU Yingxi, SUN Xiuzhen, YU Shen, WANG Jizhe, State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanicals, Dalian University of Technology, Department of Otolaryngology, the Second Affiliated Hospital of Dalian Medical University *Pages:* 545-547+562 *Year:* 2015 *Issue:* 11 *Journal:* *Chinese Archives of Otolaryngology-Head and Neck Surgery* *Keyword:* Numerical Analysis; Computer-Assisted Nasal Cavity; aerodynamics ; *Abstract:* OBJECTIVE To explore the basic c...περισσότερα »
Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma.
Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma.: *Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma.* Head Neck. 2015 Dec 26; Authors: Wong BY, Stafford ND, Green VL, Greenman J Abstract BACKGROUND: The neutrophil/lymphocyte ratio (NLR) has been found to be predictive of survival outcome in a range of tumors. The purpose of this study was to investigate the prognostic value of pretreatment (NLR) in patients with laryngeal squamous cell carcinoma (SCC). METHODS: A re...περισσότερα »
The STAT3 pathway as a therapeutic target in head and neck cancer
The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations: Proteins of the signal transducer and activator of transcription (STAT) family mediate cellular responses to cytokines and growth factors. Aberrant regulation of the STAT3 oncogene contributes to tumor formation and progression in many cancers, including head and neck squamous cell carcinoma (HNSCC), where hyperactivation of STAT3 is implicated in both treatment resistance and immune escape. There are no oncogenic gain-of-function mutations in HNSCC. Rather, aberrant STAT3 signaling is prima...περισσότερα »
Pseudocarcinomatous Hyperplasia Hiding Lymphomatoid Papulosis
Pseudocarcinomatous Hyperplasia Hiding Lymphomatoid Papulosis: A "Low-Power View" Pitfall: Pseudocarcinomatous hyperplasia (PCH) is a reactive proliferation of the epidermis that can be associated with many inflammatory and neoplastic conditions. Histologically, it is characterized by irregular strands of epidermis, usually at the level of the follicular infundibulum, projecting downward into the dermis. The differentiation between a well-differentiated squamous cell carcinoma and PCH can be particularly challenging when the biopsy is superficial and the causing lesion is dermal-ba... περισσότερα »
Lymphoepithelioma-like Carcinoma of the Skin with Perineural Invasion
Lymphoepithelioma-like Carcinoma of the Skin: A Case with Perineural Invasion: Summary: Lymphoepithelioma-like carcinoma of the skin is a rare, low malignant cutaneous neoplasm. We report a case of an elderly woman with lymphoepithelioma-like carcinoma of the skin in the forehead. The tumor was mistaken first as actinic keratosis and later as metastatic squamous cell carcinoma. A histological reassessment showed lymphoepithelioma-like carcinoma of the skin with perineural invasion, which is rare and considered more aggressive. The patient therefore received adjuvant radiotherapy aft... περισσότερα »
Personalized Medicine
Perspective for the development of companion diagnostics and regulatory landscape to encourage personalized medicine in Japan: Abstract BackgroundOn July 1st, 2013, the Ministry of Health, Labor and Welfare (MHLW) issued an official notification regarding the co-development of companion diagnostics (CDx) with a drug which requires any exclusive diagnostic test or medical device to predict efficacy or adverse reactions to the drug. The main frame and contents in the MHLW’s notification are quite similar to the summaries in the final guidance issued by the US Food and Drug Administr...περισσότερα »
Radiation recall dermatitis induced by trastuzumab
Radiation recall dermatitis induced by trastuzumab: AbstractWe report a case of radiation recall dermatitis caused by trastuzumab. A 55-year-old woman with metastatic breast cancer received palliative first-line trastuzumab/paclitaxel and a salvage partial mastectomy with lymph node dissection was subsequently performed. In spite of the palliative setting, the pathology report indicated that no residual carcinoma was present, and then she underwent locoregional radiotherapy to ensure a definitive response. After radiotherapy, she has maintained trastuzumab monotherapy. Nine days af... περισσότερα »
Tumor growth suppression by the combination of nanobubbles and ultrasound
Tumor growth suppression by the combination of nanobubbles and ultrasound: Abstract We previously developed novel liposomal nanobubbles (Bubble liposomes; BLs) that oscillate and collapse in an ultrasound field, generating heat and shock waves. We aimed to investigate the feasibility of cancer therapy by the combination of BLs and ultrasound (BLs + ultrasound). In addition, we investigated the anti-tumor mechanism of this cancer therapy. Colon-26 cells were inoculated into the flank of BALB/c mice to induce tumors. After 8 days, BLs or saline was intratumorally injected, followed by...περισσότερα »
Chronic Disease Self-Management
National study of chronic disease self-management: 6-month and 12-month findings among cancer survivors and non-cancer survivors: Abstract Objective This study examined the applicability of the Stanford Chronic Disease Self-Management Program (CDSMP) for cancer survivors and compared outcomes among cancer survivors and participants with other chronic diseases (non-cancer survivors). Methods Participants were older adults (*n* = 1170) enrolled in the National Study of CDSMP. Detailed information about physical and psychosocial health status and health and healthcare behaviors was col...περισσότερα »
Sleep disturbances and related factors among family caregivers of patients with advanced cancer
Sleep disturbances and related factors among family caregivers of patients with advanced cancer: Abstract Objective Sleep disturbances among family caregivers (FCs) are common in advanced cancer. The comprehensive factors for sleep disturbances among the FCs of patients with cancer have not been investigated in Taiwan. The purposes of this study were to investigate the sleep disturbances among the FCs of patients with advanced cancer and to determine predictors of sleep disturbance. Methods A descriptive, cross-sectional study was conducted among 172 FCs. Data were collected using ...περισσότερα »
Bone formation and implant osseointegration in large size bone defects : Autogenous PRGF+β-TCP with or without a collagen membrane
Evaluation of autogenous PRGF+β-TCP with or without a collagen membrane on bone formation and implant osseointegration in large size bone defects. A preclinical in vivo study: Abstract Objectives The aim of this study was to evaluate whether the adjunctive use of a collagen membrane enhances bone formation and implant osseointegration in non-contained defects grafted with chair-side prepared autologous platelet-rich growth factor (PRGF) adsorbed on a β-TCP particulate carrier. Materials and methods Large box-type defects (10 × 6 mm; W × D) were prepared in the edentulated and comple... περισσότερα »
Does the continuation of warfarin change management outcomes in epistaxis patients?
Does the continuation of warfarin change management outcomes in epistaxis patients?: Research Articles S Bola, R Marsh, S Braggins, C Potter, S Hickey The Journal of Laryngology Otology, FirstView Article(s), 5 pages Abstract S Bolaa1 c1, R Marsha1, S Bragginsa1, C Pottera1 and S Hickeya1 a1 Otolaryngology Department, Torbay Hospital, South Devon Healthcare Trust, Torquay, UK Abstract Objective: This study aimed to compare management, readmission rates and length of in-patient stay amongst warfarinised and non-warfarinised patients to ascertain future treatment protocols. Meth...περισσότερα »
Single cannula versus double cannula tracheostomy tubes in major oral and oropharyngeal resections
Single cannula versus double cannula tracheostomy tubes in major oral and oropharyngeal resections: Research Articles M Dhiwakar, G I Nambi, T V Ramanikanth, S M Kale, M N Sivakumar The Journal of Laryngology Otology, FirstView Article(s), 5 pages Abstract M Dhiwakara1 c1, G I Nambia2, T V Ramanikantha1, S M Kalea2 and M N Sivakumara3 a1 Department of Otolaryngology – Head and Neck Surgery, Kovai Medical Center and Hospital, Coimbatore, India a2 Department of Plastic Surgery, Kovai Medical Center and Hospital, Coimbatore, India a3 Department of Intensive Care, Kovai Medical Cen...περισσότερα »
Predictors of high-risk and low-risk oral HPV infection
Predictors of high-risk and low-risk oral HPV infection in the United States: Objectives/Hypothesis Determine predictors of high-risk and low-risk oral HPV infection in the United States. Study Design Retrospective analyses of National Health and Nutrition Examination Survey cross-sectional data of U.S. population from 2009 to 2012. Methods Database queried for subjects aged 18 to 69 with oral rinse human papillomavirus (HPV) DNA data. Logistic regression identified factors associated with high-risk and low-risk infection. Covariates included age, gender, ethnicity, income-to-povert... περισσότερα »
Otolaryngology in academia
Status and trends of general otolaryngology in academia: Objectives/Hypothesis This article focuses on the hiring trends of academic general otolaryngology practices to clarify the status of academic general otolaryngology in the face of today's changing medical landscape. Study Design Cross-sectional study. Methods We conducted a survey to evaluate past, present, and projected hiring issues in academic otolaryngology, specifically related to general otolaryngology. Surveys were sent via e-mail to all academic chairpersons of accredited otolaryngology residency programs in the United...περισσότερα »
Sensors, Vol. 16, Pages 34: The Performance Analysis of the Map-Aided Fuzzy Decision Tree Based on the Pedestrian Dead Reckoning Algorithm in an Indoor Environment
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Hardware sensors embedded in a smartphone allow the device to become an excellent mobile navigator. A smartphone is ideal for this task because its great international popularity has led to increased phone power and since most of the necessary infrastructure is already in place. However, using a smartphone for indoor pedestrian navigation can be problematic due to the low accuracy of sensors, imprecise predictability of pedestrian motion, and inaccessibility of the Global Navigation Satellite System (GNSS) in some indoor environments. Pedestrian Dead Reckoning (PDR) is one of the m... περισσότερα »
Buildings, Vol. 6, Pages 1: Acoustic Intervention in a Cultural Heritage: The Chapel of the Royal Palace in Caserta, Italy
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
The modern use of ancient heritage sites can be, to say the least, challenging from an acoustical perspective. In fact, modern needs may require acoustical interventions in contrast with the preservation issues of the cultural heritage. This paper deals with this topic in an UNESCO designated world heritage site, the Palatine Chapel of the Royal Palace in Caserta, Italy. Since this chapel is currently being used for meetings and music chamber concerts, the acoustical characteristics of the chapel, originally used for religious purposes, are investigated. Field measurements were un...περισσότερα »
Nutrients, Vol. 8, Pages 11: Clustering of Dietary Patterns, Lifestyles, and Overweight among Spanish Children and Adolescents in the ANIBES Study
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Weight gain has been associated with behaviors related to diet, sedentary lifestyle, and physical activity. We investigated dietary patterns and possible meaningful clustering of physical activity, sedentary behavior, and sleep time in Spanish children and adolescents and whether the identified clusters could be associated with overweight. Analysis was based on a subsample (n = 415) of the cross-sectional ANIBES study in Spain. We performed exploratory factor analysis and subsequent cluster analysis of dietary patterns, physical activity, sedentary behaviors, and sleep time. Logis... περισσότερα »
Religions, Vol. 7, Pages 4: “This Is Our Jerusalem”: Early American Evangelical Localizations of the Hebraic Republic
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
This paper examines how evangelical pastors applied Protestant notions of a Hebraic Republic for their parishioners as America transitioned from a colonial frontier to a new republic. As the American constitutions took shape during and after the Revolution, many evangelical pastors argued that America emulated or was inspired by the Israelite polity as described by the Old Testament. America and its institutions thus became a reincarnated Hebraic Republic, a new "city on a hill", and a new Jerusalem. Originally these pastors drew on a broader, global movement that was shaping repu... περισσότερα »
Sensors, Vol. 16, Pages 35: Effects of Operating Parameters on Measurements of Biochemical Oxygen Demand Using a Mediatorless Microbial Fuel Cell Biosensor
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
The conventional Biochemical Oxygen Demand (BOD) method takes five days to analyze samples. A microbial fuel cell (MFC) may be an alternate tool for rapid BOD determination in water. However, a MFC biosensor for continuous BOD measurements of water samples is still unavailable. In this study, a MFC biosensor inoculated with known mixed cultures was used to determine the BOD concentration. Effects of important parameters on establishing a calibration curve between the BOD concentration and output signal from the MFC were evaluated. The results indicate monosaccharides were good fuel... περισσότερα »
Sustainability, Vol. 8, Pages 26: The Optimization of Cyclic Links of Live Pig-Industry Chain Based on Circular Economics
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
To reduce waste and wastewater pollution and to improve the utilization rate of resources in the pig-industry chain, a circular economy of the chain can be developed. The key to constructing the circular economic system of the pig-industry chain is to determine the path of the cyclic materials and to design reasonable waste- and wastewater-treatment capacities. This paper focuses on the treatment and recycling of wastewater in the pig-industry chain and the treatment and recycling of waste into manure and feed. After giving the two circular paths, the paper proposes a multi-object... περισσότερα »
Nanomaterials, Vol. 6, Pages 3: Receptor-Mediated Drug Delivery Systems Targeting to Glioma
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Glioma has been considered to be the most frequent primary tumor within the central nervous system (CNS). The complexity of glioma, especially the existence of the blood-brain barrier (BBB), makes the survival and prognosis of glioma remain poor even after a standard treatment based on surgery, radiotherapy, and chemotherapy. This provides a rationale for the development of some novel therapeutic strategies. Among them, receptor-mediated drug delivery is a specific pattern taking advantage of differential expression of receptors between tumors and normal tissues. The strategy can ...περισσότερα »
Humanities, Vol. 5, Pages 3: On Sound: Reconstructing a Zhuangzian Perspective of Music
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
A devotion to music in Chinese classical texts is worth noticing. Early Chinese thinkers saw music as a significant part of human experience and a core practice for philosophy. While Confucian endorsement of ritual and music has been discussed in the field, Daoist understanding of music was hardly explored. This paper will make a careful reading of the Xiánchí 咸池 music story in the Zhuangzi, one of the most interesting, but least noticed texts, and reconstruct a Zhuangzian perspective from it. While sounds had been regarded as mere building blocks of music and thus depreciated in t... περισσότερα »
Toxins, Vol. 8, Pages 5: Development of an Enzyme-Linked Immunosorbent Assay Method Specific for the Detection of G-Group Aflatoxins
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
To detect and monitor G-group aflatoxins in agricultural products, we generated class-specific monoclonal antibodies that specifically recognized aflatoxins G1 and G2. Of the final three positive and stable hybridomas obtained, clone 2G6 produced a monoclonal antibody that had equal sensitivity to aflatoxins G1 and G2, and did not cross-react with aflatoxins B1, B2, or M1. Its IC50 values for aflatoxins G1 and G2 were 17.18 ng·mL−1 and 19.75 ng·mL−1, respectively. Using this new monoclonal antibody, we developed a competitive indirect enzyme-linked immunosorbent assay (CI-ELISA); ...περισσότερα »
Highlights: Volume 231, Number 4
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Editor's Choice
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Withdrawal Statement: Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages by Huwait, E.A., Singh, N.N., Michael, D.R., Davies, T.S., Moss, J.W.E., and Ramji, D.P.
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Table of Contents: Volume 231, Number 4
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Does systemic antipsoriatic therapy affect the cardiovascular risk?
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Conflicts of interest in dermatology: a medical student and mentor perspective
Summary Conflict of interest (COI) in medicine is well defined, but is seldom discussed in the field of dermatology. This perspective sheds light on this topic in dermatology and provides suggestions on how better to approach COI in medical school and residency. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1YMy1PT via IFTTT
Occupational contact urticaria: a diagnosis not to be missed
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Editor’s Choice
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British Society for Paediatric Dermatology Annual Meeting, October 2nd 2015, Keble College, Oxford, U.K.
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Plain language summaries
Linked Article: Saunte et al. Br Jr Dermatol 2015; 173: 1546–1549 Linked Article: Cheng and Guitera Br Jr Dermatol 2015; 173: 1371–1380 Linked Article: Bensefa-Colas et al. Br Jr Dermatol 2015; 173: 1453–1461 Linked Article: Drielen et al. Br Jr Dermatol 2015; 173: 1550–1552 Linked Article: Chavez-Bourgeois and Iglesias Br Jr Dermatol 2015; 173: 1553–1555… Continue reading Plain language summaries
BJD in translation
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Next-generation antipsoriatic drugs: small molecules join
Linked Article: Paul, et al. Br J Dermatol 2015; 173: 1387–99. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1IypNJs via IFTTT
Chilblain lesions associated with inherited autoimmune disease
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Paraneoplastic pemphigus: an entity still in search of an identity?
Linked Article: Ohzono, et al. Br J Dermatol 2015; 173:1447–52. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1IypPAM via IFTTT
Influence of the Alcohol Present in a Phytotherapic Tincture on Male Rat Lipid Profiles and Renal Function
This study evaluated the influence of the alcohol present in a formulation of the antiophidic phytotherapic tincture, Específico-Pessôa, on rat blood biochemical and hematological parameters, and on organ histology. Three groups of rats were treated orally for 10, 15, or 30 days; one group received the tincture, the other received alcohol alone, and the third was a control group. The results of this study indicated that cholesterol levels were significantly increased after 10 days in the alcohol and tincture groups, although these decreased after 30 days in the tincture group. Tri... περισσότερα »
Energies, Vol. 9, Pages 18: Performance Characteristics of a Modularized and Integrated PTC Heating System for an Electric Vehicle
A modularized positive temperature coefficient heating system has controller-integrated heater modules. Such a heating system that uses a high-voltage power of 330 V was developed in the present study for use in electric vehicles. Four heater modules and one controller with an input power of 5.6 kW were integrated in the modularized system, which was designed for improved heating power density and light weight compared to the conventional heating system, in which the controller is separated. We experimentally investigated the performance characteristics, namely, the heating capaci... περισσότερα »
Molecules, Vol. 21, Pages 8: The Synthesis of the Metabolites of 2′,3′,5′-Tri-O-acetyl-N6-(3-hydroxyphenyl) Adenosine (WS070117)
Seven metabolites of 2′,3′,5′-tri-O-acetyl-N6-(3-hydroxyphenyl) adenosine (WS070117) were synthesized by deacetylation, hydrolysis, cyclization, sulfonylation and glycosylation reactions, respectively. All these compounds, which could be useful as material standards for metabolic research, were characterized by NMR and HPLC-MS (ESI) analyses. from #Medicine via ola Kala on Inoreader http://ift.tt/1MCZTim via IFTTT
Symmetry, Vol. 8, Pages 1: Structural Properties and Biological Prediction of ({[(1E)-3-(1H-Imidazol-1-yl)-1-phenylpropylidene] amino}oxy)(4-methylphenyl)methanone: An In Silico Approach
Bioactive molecules are playing essential role in the field of drug discovery and various pharmaceutical applications. Vibrational spectral investigations of the anti-Candida agent ({[(1E)-3-(1H-imidazol-1-yl)-1-phenylpropylidene]amino}oxy)(4-methylphenyl)methanone ((1E)-IPMM) have been recorded and analyzed to understand its structural geometry, inter- and intra-molecular interactions. The equilibrium geometry, harmonic vibrational wavenumber, natural bond orbital (NBO) and Frontier orbital energy analyses have been carried out with the help of density functional theory with B3LY... περισσότερα »
Molecules, Vol. 21, Pages 31: Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7
Two new β-bergamotane sesquiterpenoids, E-β-trans-5,8,11-trihydroxybergamot-9-ene (1) and β-trans-2β,5,15-trihydroxybergamot-10-ene (2), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with three known terpenoids 3–5. Their structures were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were measured in vitro. Compound 4 exhibited potent activity against the U937 cell line with an IC50 value of 4.2 μM. from #Medicine via ola K... περισσότερα »
Sensors, Vol. 16, Pages 34: The Performance Analysis of the Map-Aided Fuzzy Decision Tree Based on the Pedestrian Dead Reckoning Algorithm in an Indoor Environment
Hardware sensors embedded in a smartphone allow the device to become an excellent mobile navigator. A smartphone is ideal for this task because its great international popularity has led to increased phone power and since most of the necessary infrastructure is already in place. However, using a smartphone for indoor pedestrian navigation can be problematic due to the low accuracy of sensors, imprecise predictability of pedestrian motion, and inaccessibility of the Global Navigation Satellite System (GNSS) in some indoor environments. Pedestrian Dead Reckoning (PDR) is one of the m... περισσότερα »
Buildings, Vol. 6, Pages 1: Acoustic Intervention in a Cultural Heritage: The Chapel of the Royal Palace in Caserta, Italy
The modern use of ancient heritage sites can be, to say the least, challenging from an acoustical perspective. In fact, modern needs may require acoustical interventions in contrast with the preservation issues of the cultural heritage. This paper deals with this topic in an UNESCO designated world heritage site, the Palatine Chapel of the Royal Palace in Caserta, Italy. Since this chapel is currently being used for meetings and music chamber concerts, the acoustical characteristics of the chapel, originally used for religious purposes, are investigated. Field measurements were un...περισσότερα »
Nutrients, Vol. 8, Pages 11: Clustering of Dietary Patterns, Lifestyles, and Overweight among Spanish Children and Adolescents in the ANIBES Study
Weight gain has been associated with behaviors related to diet, sedentary lifestyle, and physical activity. We investigated dietary patterns and possible meaningful clustering of physical activity, sedentary behavior, and sleep time in Spanish children and adolescents and whether the identified clusters could be associated with overweight. Analysis was based on a subsample (n = 415) of the cross-sectional ANIBES study in Spain. We performed exploratory factor analysis and subsequent cluster analysis of dietary patterns, physical activity, sedentary behaviors, and sleep time. Logis... περισσότερα »
Religions, Vol. 7, Pages 4: “This Is Our Jerusalem”: Early American Evangelical Localizations of the Hebraic Republic
This paper examines how evangelical pastors applied Protestant notions of a Hebraic Republic for their parishioners as America transitioned from a colonial frontier to a new republic. As the American constitutions took shape during and after the Revolution, many evangelical pastors argued that America emulated or was inspired by the Israelite polity as described by the Old Testament. America and its institutions thus became a reincarnated Hebraic Republic, a new "city on a hill", and a new Jerusalem. Originally these pastors drew on a broader, global movement that was shaping repu... περισσότερα »
Sensors, Vol. 16, Pages 35: Effects of Operating Parameters on Measurements of Biochemical Oxygen Demand Using a Mediatorless Microbial Fuel Cell Biosensor
The conventional Biochemical Oxygen Demand (BOD) method takes five days to analyze samples. A microbial fuel cell (MFC) may be an alternate tool for rapid BOD determination in water. However, a MFC biosensor for continuous BOD measurements of water samples is still unavailable. In this study, a MFC biosensor inoculated with known mixed cultures was used to determine the BOD concentration. Effects of important parameters on establishing a calibration curve between the BOD concentration and output signal from the MFC were evaluated. The results indicate monosaccharides were good fuel... περισσότερα »
Sustainability, Vol. 8, Pages 26: The Optimization of Cyclic Links of Live Pig-Industry Chain Based on Circular Economics
To reduce waste and wastewater pollution and to improve the utilization rate of resources in the pig-industry chain, a circular economy of the chain can be developed. The key to constructing the circular economic system of the pig-industry chain is to determine the path of the cyclic materials and to design reasonable waste- and wastewater-treatment capacities. This paper focuses on the treatment and recycling of wastewater in the pig-industry chain and the treatment and recycling of waste into manure and feed. After giving the two circular paths, the paper proposes a multi-object... περισσότερα »
Nanomaterials, Vol. 6, Pages 3: Receptor-Mediated Drug Delivery Systems Targeting to Glioma
Glioma has been considered to be the most frequent primary tumor within the central nervous system (CNS). The complexity of glioma, especially the existence of the blood-brain barrier (BBB), makes the survival and prognosis of glioma remain poor even after a standard treatment based on surgery, radiotherapy, and chemotherapy. This provides a rationale for the development of some novel therapeutic strategies. Among them, receptor-mediated drug delivery is a specific pattern taking advantage of differential expression of receptors between tumors and normal tissues. The strategy can ...περισσότερα »
European Journal of Epidemiology, Vol. 30, Issue 12 - New Issue Alert
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 58 δευτερόλεπτα
If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 12/28/2015 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *European Journal of Epidemiology*. Volume 30 Number 12 is now available online. Important news Recognized as a top Open Choice journal This journal has been recognized as a top Open Choice journal for its exceptional output of open access articles. Open Choice: Your research. Your choice. Learn more! In this issue Editorial A note of thanks Albert Hofma... περισσότερα »
Erratum
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1MCSLCN via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Oots8D via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mKksom via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1YIdrFI via IFTTT
Are We Ready for Mass Fatality Incidents? Preparedness of the US Mass Fatality Infrastructure
Research Articles Jacqueline A. Merrill, Mark Orr, Daniel Y. Chen, Qi Zhi, Robyn R. Gershon Disaster Medicine and Public Health Preparedness, FirstView Article(s), 11 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1JbQDqD via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Oots8B via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1MCUyrh...περισσότερα »
Investigation of Cytotoxic T‐lymphocyte antigen 4 (CTLA4) Polymorphisms in Gastric Cardia Adenocarcinoma
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RNFBun via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mKitQK via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mKkqNe via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PrZqEf via IFTTT
Increased B regulatory phenotype in non‐metastatic lymph nodes of node positive breast cancer patients
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PrUYW9 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OotpcR via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1MCUwQn via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PrZqEd via IFTTT
Blockade of Interlukin‐17 restrains the development of acute lung injury
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RNFyir via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Oots8u via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mKkqN8 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PrZrZ0 via IFTTT
Increased levels of interferon‐inducible protein 10 (IP‐10) in 22q11.2 Deletion Syndrome
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RNFBdV via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OotpcP via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1MCUyaZ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1YIdrFz via IFTTT
A Pipeline for Classifying Relationships Using Dense SNP/SNV Data and Putative Pedigree Information
ABSTRACT When genome-wide association studies (GWAS) or sequencing studies are performed on family-based datasets, the genotype data can be used to check the structure of putative pedigrees. Even in datasets of putatively unrelated people, close relationships can often be detected using dense single-nucleotide polymorphism/variant (SNP/SNV) data. A number of methods for finding relationships using dense genetic data exist, but they all have certain limitations, including that they typically use average genetic sharing, which is only a subset of the available information. Here, we ...περισσότερα »
A mutation in COL4A2 causes autosomal dominant porencephaly with cataracts
Mutations in *COL4A1* are well described and result in brain abnormalities manifesting with severe neurological deficits including cerebral palsy, intellectual disability, and focal epilepsy. Families with mutations in *COL4A2* are now emerging with a similar phenotype. We describe a family with an autosomal dominant disorder comprising porencephaly, focal epilepsy, and lens opacities, which was negative for mutations in *COL4A1*. Using whole exome sequencing of three affected individuals from three generations, we identified a rare variant in *COL4A2*. This *COL4A2* (c.2399G>A, ...περισσότερα »
Further evidence of a mutation in CDC42 as a cause of a recognizable syndromic form of thrombocytopenia
We previously documented a girl with macrothrombocytopenia and developmental delay who carried a de novo mutation in *CDC42*, which plays pivotal roles in the cell cycle and the formation of the actin cytoskeleton. The phenotype of mice lacking *Cdc42* was strikingly similar to that of the reported patient, indicating that the mutation in *CDC42* causes a new syndromic form of thrombocytopenia. We, herein, report another unrelated female patient with a similar phenotype and a de novo mutation in the same *CDC42*. The present observation provides further evidence supporting the no... περισσότερα »
Inaccuracy of non-invasive prenatal screening demands cautious counsel and follow-up
from Genes via ola Kala on Inoreader http://ift.tt/1Tmzgns via IFTTT
Behavior of melanocytes and keratinocytes in reticulate acropigmentation of Kitamura
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Reticulate acropigmentation of Kitamura (RAK, OMIM 615537) is a rare genetic pigmentary disorder that usually shows an autosomal dominant pattern of inheritance with high penetrance. The disorder was first described by Kitamura and Akamatsu in 1943, and then reported worldwide in 1953 (Kitamura et al., 1953). RAK patients typically present within the first or […]
Spectrum of EGFR gene mutations in Vietnamese patients with non–small cell lung cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
ConclusionDNA sequencing detected EGFR mutations with high frequency and revealed a broad spectrum of mutation type in Vietnamese patients with NSCLC. (Source: Asia-Pacific Journal of Clinical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OgMMJf via IFTTT
Komplett subkutaner implantierbarer Kardioverter-Defibrillator
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Betreuung während Entbindung Inadäquate Schockabgaben sind bei subkutanen implantierbaren Kardioverter-Defibrillatoren (S-ICDs) ein beschriebenes Problem. Situationen, wie z. B. der Geburtsvorgang, die für inadäquate Schockabgaben prädisponieren, müssen erkannt und die beste Behandlungsstrategie muss gewählt werden. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R3gzWB via IFTTT
Diagnostik und Therapie der Nephrolithiasis: Was ist gesichert?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Fortbildung Nierensteine sind eine häufige Ursache von Nierenerkrankungen mit meist chronischem Verlauf und hoher Rezidivhäufigkeit. Im folgenden Beitrag werden für den Internisten die diagnostische Herangehensweise beim symptomatischen Nierenstein und die therapeutischen Optionen beleuchtet. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mlXnYp via IFTTT
Ki67—An unsuitable marker of gastric cancer prognosis unmasks intratumoral heterogeneity
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
ConclusionTMAs carry the risk of a systematic underestimation of the Ki67 PI. Ki67 has no prognostic value in GC but might be a potential indicator of intratumoral heterogeneity. J. Surg. Oncol. © 2015 The Authors. Journal of Surgical Oncology published by Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader […]
The importance of surgical margins in retroperitoneal sarcoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Surgery is the “gold‐standard” treatment for retroperitoneal sarcomas, but local recurrence is common, and can cause disease‐related death. Complete gross resection is associated with improved survival, but debate exists as to whether resection of adjacent organs to improve margins or prescription of neoadjuvant radiation leads to better outcomes. This review summarizes data addressing prognostic value […]
Prediction of survival and tumor recurrence in patients undergoing surgery for pancreatic neuroendocrine neoplasms
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
ConclusionsThe platelet count was identified as a relevant risk factor. Proposed prognostic models with good model‐fit display properties that indicate potential clinical usefulness. J. Surg. Oncol. © 2015 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mlWAGV via IFTTT
Atmosphere, Vol. 7, Pages 3: Erratum: Hassan, M.; et al. An Assessment of the South Asian Summer Monsoon Variability for Present and Future Climatologies Using a High Resolution Regional Climate Model (RegCM4.3) under the AR5 Scenarios. Atmosp here 2015, 6, 1833–1857
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The published date in the paper [1] should be 23 November 2015. We apologize to the authors of the paper and readers of Atmosphere for any inconvenience caused. […] from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1MCZSuX via IFTTT
Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Wnt5a-Ror2 signaling has been shown to play important roles in promoting aggressiveness of various cancer cells in a cell-autonomous manner. However, little is known about its function in cancer-associated stromal cells, including mesenchymal stem cells (MSCs). Thus, we examined the role of Wnt5a-Ror2 signaling in bone marrow-derived MSCs in regulating proliferation of undifferentiated gastric […]
FOXA1 expression affects to the proliferation activity of luminal breast cancer stem cell populations
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract The expression of estrogen receptor (ER) is the key in most breast cancers (BC) and binding of ER to the genome correlates to Forkhead protein (FOXA1) expression. We herein assessed the correlation between the cancer stem cell (CSC) population and FOXA1 expression in luminal breast cancer (BC). We established luminal BC cells derived from […]
Remodelling of elastic fibres in striae gravidarum
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Linked Article: Wang, et al. Br J Dermatol 2015; 173: 1420–30. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1YMy3Y5 via IFTTT
News and Notices
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1IypRJ1 via IFTTT
Fragrance contact allergy in the population
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Linked Article: Diepgen, et al. Br J Dermatol 2015; 173: 1411–19. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1YMy4vc via IFTTT
Burden of disease scoring in epidermolysis bullosa
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Linked Article: Dufresne, et al. Br J Dermatol 2015; 173: 1405–10. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1IypONv via IFTTT
The clinical relevance of dermoscopic naevus patterns
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Linked Article: Fonseca, et al. Br J Dermatol 2015; 173:1486–93. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1IypONo via IFTTT
Growth and hormonal profiling in children with congenital melanocytic naevi
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Linked Article: Waelchli, et al. Br J Dermatol 2015; 173:1471–78. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1IypQF7 via IFTTT
Navigating uncertainty: a valuable cost-effectiveness analysis in the rapidly changing field of metastatic melanoma treatment
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Linked Article: Matter-Walstra, et al. Br J Dermatol 2015; 173:1462–70. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1IypQEX via IFTTT
Can we trust questions about self-reported and caregiver-reported eczema in epidemiological studies?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Linked Article: Silverberg, et al. Br J Dermatol 2015; 173: 1400–4. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1YMy2Di via IFTTT
Does systemic antipsoriatic therapy affect the cardiovascular risk?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Linked Article: Cohen-Barak, et al. Br J Dermatol 2015; 173:1440–46. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1YMy2mY via IFTTT
Occupational contact urticaria: a diagnosis not to be missed
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Linked Article: Bensefa-Colas, et al. Br J Dermatol 2015; 173:1453–61. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1IypOwJ via IFTTT
Ki67—An unsuitable marker of gastric cancer prognosis unmasks intratumoral heterogeneity
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ConclusionTMAs carry the risk of a systematic underestimation of the Ki67 PI. Ki67 has no prognostic value in GC but might be a potential indicator of intratumoral heterogeneity. J. Surg. Oncol. © 2015 The Authors. Journal of Surgical Oncology published by Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader […]
The importance of surgical margins in retroperitoneal sarcoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Surgery is the “gold‐standard” treatment for retroperitoneal sarcomas, but local recurrence is common, and can cause disease‐related death. Complete gross resection is associated with improved survival, but debate exists as to whether resection of adjacent organs to improve margins or prescription of neoadjuvant radiation leads to better outcomes. This review summarizes data addressing prognostic value […]
Prediction of survival and tumor recurrence in patients undergoing surgery for pancreatic neuroendocrine neoplasms
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ConclusionsThe platelet count was identified as a relevant risk factor. Proposed prognostic models with good model‐fit display properties that indicate potential clinical usefulness. J. Surg. Oncol. © 2015 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mlWAGV via IFTTT
Atmosphere, Vol. 7, Pages 3: Erratum: Hassan, M.; et al. An Assessment of the South Asian Summer Monsoon Variability for Present and Future Climatologies Using a High Resolution Regional Climate Model (RegCM4.3) under the AR5 Scenarios. Atmosp here 2015, 6, 1833–1857
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The published date in the paper [1] should be 23 November 2015. We apologize to the authors of the paper and readers of Atmosphere for any inconvenience caused. […] from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1MCZSuX via IFTTT
Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Wnt5a-Ror2 signaling has been shown to play important roles in promoting aggressiveness of various cancer cells in a cell-autonomous manner. However, little is known about its function in cancer-associated stromal cells, including mesenchymal stem cells (MSCs). Thus, we examined the role of Wnt5a-Ror2 signaling in bone marrow-derived MSCs in regulating proliferation of undifferentiated gastric […]
FOXA1 expression affects to the proliferation activity of luminal breast cancer stem cell populations
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract The expression of estrogen receptor (ER) is the key in most breast cancers (BC) and binding of ER to the genome correlates to Forkhead protein (FOXA1) expression. We herein assessed the correlation between the cancer stem cell (CSC) population and FOXA1 expression in luminal breast cancer (BC). We established luminal BC cells derived from […]
Tumor growth suppression by the combination of nanobubbles and ultrasound
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This article is protected by copyright. All rights reserved. (Source: Cancer Science) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mKy1nB via IFTTT
A sensitive cytometry based system for enumeration, capture and analysis of gene mutations of circulating tumor cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This article is protected by copyright. All rights reserved. (Source: Cancer Science) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OTHcZF via IFTTT
MiR‐127‐5p targets the biliverdin reductase B/NF‐κB pathway to suppress cell growth in hepatocellular carcinoma cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This article is protected by copyright. All rights reserved. (Source: Cancer Science) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mKy3vQ via IFTTT
Spatial variation in osteon population density at the human femoral midshaft: histomorphometric adaptations to habitual load environment
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Intracortical remodeling, and the osteons it produces, is one aspect of the bone microstructure that is influenced by and, in turn, can influence its mechanical properties. Previous research examining the spatial distribution of intracortical remodeling density across the femoral midshaft has been limited to either considering only small regions of the cortex or, when […]
Mit dem Oxytocinspiegel steigt der Wille zu spenden
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Eingeschränkt gültig Hoher Oxytocinspiegel – hohe Spendenbereitschaft. Dies gilt aber wohl nur für soziale, nicht für ökologische Projekte. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OuxLFH via IFTTT
Echinocandin to fluconazole step-down therapy in critically ill patients with invasive, susceptible Candida albicans infections
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Invasive Candida spp. infections are increasingly diagnosed in critically ill patients. For initial treatment, an echinocandin is recommended with a possible step-down to fluconazole when the patients’ condition is improving and the isolate appears susceptible, but there are no data to support such policy. We studied the safety and efficacy of step-down therapy in […]
Evaluation of autogenous PRGF+β-TCP with or without a collagen membrane on bone formation and implant osseointegrat ion in large size bone defects. A preclinical in vivo study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives The aim of this study was to evaluate whether the adjunctive use of a collagen membrane enhances bone formation and implant osseointegration in non-contained defects grafted with chair-side prepared autologous platelet-rich growth factor (PRGF) adsorbed on a β-TCP particulate carrier. Materials and methods Large box-type defects (10 × 6 mm; W × D) […]
Wallerian degeneration of the pontocerebellar fibres secondary to pontine infarction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1JE3BbB via IFTTT
Status and trends of general otolaryngology in academia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives/Hypothesis This article focuses on the hiring trends of academic general otolaryngology practices to clarify the status of academic general otolaryngology in the face of today’s changing medical landscape. Study Design Cross-sectional study. Methods We conducted a survey to evaluate past, present, and projected hiring issues in academic otolaryngology, specifically related to general otolaryngology. Surveys […]
Predictors of high-risk and low-risk oral HPV infection in the United States
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives/Hypothesis Determine predictors of high-risk and low-risk oral HPV infection in the United States. Study Design Retrospective analyses of National Health and Nutrition Examination Survey cross-sectional data of U.S. population from 2009 to 2012. Methods Database queried for subjects aged 18 to 69 with oral rinse human papillomavirus (HPV) DNA data. Logistic regression identified factors […]
Erratum
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1MCSLCN via IFTTT
Mit dem Oxytocinspiegel steigt der Wille zu spenden
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Eingeschränkt gültig Hoher Oxytocinspiegel – hohe Spendenbereitschaft. Dies gilt aber wohl nur für soziale, nicht für ökologische Projekte. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OuxLFH via IFTTT
Echinocandin to fluconazole step-down therapy in critically ill patients with invasive, susceptible Candida albicans infections
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Invasive Candida spp. infections are increasingly diagnosed in critically ill patients. For initial treatment, an echinocandin is recommended with a possible step-down to fluconazole when the patients’ condition is improving and the isolate appears susceptible, but there are no data to support such policy. We studied the safety and efficacy of step-down therapy in […]
Evaluation of autogenous PRGF+β-TCP with or without a collagen membrane on bone formation and implant osseointegrat ion in large size bone defects. A preclinical in vivo study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives The aim of this study was to evaluate whether the adjunctive use of a collagen membrane enhances bone formation and implant osseointegration in non-contained defects grafted with chair-side prepared autologous platelet-rich growth factor (PRGF) adsorbed on a β-TCP particulate carrier. Materials and methods Large box-type defects (10 × 6 mm; W × D) […]
Spatial variation in osteon population density at the human femoral midshaft: histomorphometric adaptations to habitual load environment
Abstract Intracortical remodeling, and the osteons it produces, is one aspect of the bone microstructure that is influenced by and, in turn, can influence its mechanical properties. Previous research examining the spatial distribution of intracortical remodeling density across the femoral midshaft has been limited to either considering only small regions of the cortex or, when looking at the entirety of the cortex, considering only a single individual. This study examined the spatial distribution of all remodeling events (intact osteons, fragmentary osteons, and resorptive bays) ac... περισσότερα »
Spatial variation in osteon population density at the human femoral midshaft: histomorphometric adaptations to habitual load environment
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Intracortical remodeling, and the osteons it produces, is one aspect of the bone microstructure that is influenced by and, in turn, can influence its mechanical properties. Previous research examining the spatial distribution of intracortical remodeling density across the femoral midshaft has been limited to either considering only small regions of the cortex or, when […]
Timing of routine infant vaccinations and risk of food allergy and eczema at one year of age
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Epidemiological evidence suggests that routine vaccinations can have non-targeted effects on susceptibility to infections and allergic disease. Such effects may depend on age at vaccination, and a delay in pertussis vaccination has been linked to reduced risk of allergic disease. We aimed to test the hypothesis that delay in vaccines containing diphtheria-tetanus-acelullar pertussis […]
IJMS, Vol. 17, Pages 37: The Role of bFGF in the Excessive Activation of Astrocytes Is Related to the Inhibition of TLR4/NFκB Signals
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Astrocytes have critical roles in immune defense, homeostasis, metabolism, and synaptic remodeling and function in the central nervous system (CNS); however, excessive activation of astrocytes with increased intermediate filaments following neuronal trauma, infection, ischemia, stroke, and neurodegenerative diseases results in a pro-inflammatory environment and promotes neuronal death. As an important neurotrophic factor, the secretion of […]
IJMS, Vol. 17, Pages 33: Targeted Radionuclide Therapy of Human Tumors
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Targeted radionuclide therapy is one of the most intensively developing directions of nuclear medicine. Unlike conventional external beam therapy, the targeted radionuclide therapy causes less collateral damage to normal tissues and allows targeted drug delivery to a clinically diagnosed neoplastic malformations, as well as metastasized cells and cellular clusters, thus providing systemic therapy of cancer. […]
IJMS, Vol. 17, Pages 25: Interleukin-10 Protection against Lipopolysaccharide-Induced Neuro-Inflammation and Neurotoxicity in Ventral Mesencephalic Cultures
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Interleukin (IL)-10, an anti-inflammatory cytokine, is expressed in the brain and can inhibit microglial activation. Herein, we utilized lipopolysaccharide (LPS)-induced inflammatory Parkinson’s disease (PD) cell model to determine whether microglia and astrocytes are necessary targets for IL-10 neuroprotection. Primary ventral mesencephalic (VM) cultures with different composition of neurons, microglia and astrocytes were prepared. The cells […]
Humanities, Vol. 5, Pages 3: On Sound: Reconstructing a Zhuangzian Perspective of Music
A devotion to music in Chinese classical texts is worth noticing. Early Chinese thinkers saw music as a significant part of human experience and a core practice for philosophy. While Confucian endorsement of ritual and music has been discussed in the field, Daoist understanding of music was hardly explored. This paper will make a careful reading of the Xiánchí 咸池 music story in the Zhuangzi, one of the most interesting, but least noticed texts, and reconstruct a Zhuangzian perspective from it. While sounds had been regarded as mere building blocks of music and thus depreciated in t... περισσότερα »
Toxins, Vol. 8, Pages 5: Development of an Enzyme-Linked Immunosorbent Assay Method Specific for the Detection of G-Group Aflatoxins
To detect and monitor G-group aflatoxins in agricultural products, we generated class-specific monoclonal antibodies that specifically recognized aflatoxins G1 and G2. Of the final three positive and stable hybridomas obtained, clone 2G6 produced a monoclonal antibody that had equal sensitivity to aflatoxins G1 and G2, and did not cross-react with aflatoxins B1, B2, or M1. Its IC50 values for aflatoxins G1 and G2 were 17.18 ng·mL−1 and 19.75 ng·mL−1, respectively. Using this new monoclonal antibody, we developed a competitive indirect enzyme-linked immunosorbent assay (CI-ELISA); ...περισσότερα »
Atmosphere, Vol. 7, Pages 3: Erratum: Hassan, M.; et al. An Assessment of the South Asian Summer Monsoon Variability for Present and Future Climatologies Using a High Resolution Regional Climate Model (RegCM4.3) under the AR5 Scenarios. Atmosphere 2015, 6, 1833–1857
The published date in the paper [1] should be 23 November 2015. We apologize to the authors of the paper and readers of Atmosphere for any inconvenience caused. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1MCZSuX via IFTTT
Systems, Vol. 4, Pages 2: A Research on Active Control to Synchronize a New 3D Chaotic System
This paper presents the robust synchronization problem of a 3D chaotic system by using the active control technique. Based on the Gershgorin theorem and Routh-Hurwitz criterion, sufficient algebraic conditions are derived to design a linear controller gain matrix. The conditions are then applied for the robust stability of the synchronization error dynamics in the presence of an unknown bounded smooth external disturbance. The proposed active control strategy with a suitable computation of the linear controller gain matrix is simple in design and establishes fast convergence rates... περισσότερα »
Nutrients, Vol. 8, Pages 16: Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions
Chlorogenic acids (CGAs) are esters formed between caffeic and quinic acids, and represent an abundant group of plant polyphenols present in the human diet. CGAs have different subgroups that include caffeoylquinic, p-coumaroylquinic, and feruloyquinic acids. Results of epidemiological studies suggest that the consumption of beverages such as coffee, tea, wine, different herbal infusions, and also some fruit juices is linked to reduced risks of developing different chronic diseases. These beverages contain CGAs present in different concentrations and isomeric mixtures. The underly... περισσότερα »
IJMS, Vol. 17, Pages 37: The Role of bFGF in the Excessive Activation of Astrocytes Is Related to the Inhibition of TLR4/NFκB Signals
Astrocytes have critical roles in immune defense, homeostasis, metabolism, and synaptic remodeling and function in the central nervous system (CNS); however, excessive activation of astrocytes with increased intermediate filaments following neuronal trauma, infection, ischemia, stroke, and neurodegenerative diseases results in a pro-inflammatory environment and promotes neuronal death. As an important neurotrophic factor, the secretion of endogenous basic fibroblast growth factor (bFGF) contributes to the protective effect of neuronal cells, but the mechanism of bFGF in reactive a... περισσότερα »
IJMS, Vol. 17, Pages 33: Targeted Radionuclide Therapy of Human Tumors
Targeted radionuclide therapy is one of the most intensively developing directions of nuclear medicine. Unlike conventional external beam therapy, the targeted radionuclide therapy causes less collateral damage to normal tissues and allows targeted drug delivery to a clinically diagnosed neoplastic malformations, as well as metastasized cells and cellular clusters, thus providing systemic therapy of cancer. The methods of targeted radionuclide therapy are based on the use of molecular carriers of radionuclides with high affinity to antigens on the surface of tumor cells. The poten... περισσότερα »
IJMS, Vol. 17, Pages 25: Interleukin-10 Protection against Lipopolysaccharide-Induced Neuro-Inflammation and Neurotoxicity in Ventral Mesencephalic Cultures
Interleukin (IL)-10, an anti-inflammatory cytokine, is expressed in the brain and can inhibit microglial activation. Herein, we utilized lipopolysaccharide (LPS)-induced inflammatory Parkinson's disease (PD) cell model to determine whether microglia and astrocytes are necessary targets for IL-10 neuroprotection. Primary ventral mesencephalic (VM) cultures with different composition of neurons, microglia and astrocytes were prepared. The cells were exposed to IL-10 (15, 50 or 150 ng/mL) 1 h prior to LPS (50 ng/mL) treatment. LPS induced dopaminergic and non-dopaminergic neuronal lo... περισσότερα »
Sustainability, Vol. 8, Pages 25: Using Social Media for Emergency Response and Urban Sustainability: A Case Study of the 2012 Beijing Rainstorm
With the proliferation of social media, information generated and disseminated from these outlets has become an important part of our everyday lives. For example, this type of information has great potential for effectively distributing political messages, hazard alerts, or messages of other social functions. In this work, we report a case study of the 2012 Beijing Rainstorm to investigate how emergency information was timely distributed using social media during emergency events. We present a classification and location model for social media text streams during emergency events.... περισσότερα »
Atmosphere, Vol. 7, Pages 3: Erratum: Hassan, M.; et al. An Assessment of the South Asian Summer Monsoon Variability for Present and Future Climatologies Using a High Resolution Regional Climate Model (RegCM4.3) under the AR5 Scenarios. Atmosphere 2015, 6, 1833–1857
The published date in the paper [1] should be 23 November 2015. We apologize to the authors of the paper and readers of Atmosphere for any inconvenience caused. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1MCZSuX via IFTTT
Systems, Vol. 4, Pages 2: A Research on Active Control to Synchronize a New 3D Chaotic System
This paper presents the robust synchronization problem of a 3D chaotic system by using the active control technique. Based on the Gershgorin theorem and Routh-Hurwitz criterion, sufficient algebraic conditions are derived to design a linear controller gain matrix. The conditions are then applied for the robust stability of the synchronization error dynamics in the presence of an unknown bounded smooth external disturbance. The proposed active control strategy with a suitable computation of the linear controller gain matrix is simple in design and establishes fast convergence rates... περισσότερα »
Nutrients, Vol. 8, Pages 16: Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions
Chlorogenic acids (CGAs) are esters formed between caffeic and quinic acids, and represent an abundant group of plant polyphenols present in the human diet. CGAs have different subgroups that include caffeoylquinic, p-coumaroylquinic, and feruloyquinic acids. Results of epidemiological studies suggest that the consumption of beverages such as coffee, tea, wine, different herbal infusions, and also some fruit juices is linked to reduced risks of developing different chronic diseases. These beverages contain CGAs present in different concentrations and isomeric mixtures. The underly... περισσότερα »
Effect of various light curing times on the elution of composite components
Abstract Objectives Polymerization of resin-based composites (RBCs) is incomplete. The aim of the present study was to determine whether a longer curing time than recommended by the manufacturer influences the amount of released composite components of RBCs. Materials and methods The composites Clearfil AP-X and els extra low shrinkage were polymerized for six different curing times: 4, 10, 20, 40, 100, and 200 s. Light curing time recommended by the manufacturer for both composites is 20 s. Subsequently, samples were eluted in methanol and water for 1, 3, and 7 days and analyzed... περισσότερα »
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