Utility of Microhemorrhage as a Diagnostic Tool in Distinguishing Vestibular Schwannomas from other Cerebellopontine Angle (CPA) Tumors

xlomafota13 shared this article with you from Inoreader Utility of Microhemorrhage as a Diagnostic Tool in Distinguishing Vestibular Schwannomas from other Cerebellopontine Angle (CPA) Tumors Via Otolaryngology Indian Abstract Although a majority of tumors in the Cerebellopontine Angle (CPA) are vestibular schwannomas (VS), other masses can also be seen in the region and differentiation of various CPA tumors, particularly meningiomas can be difficult on imaging alone. Treatment options may vary based on specific pathology of the CPA tumor. In this study, the presence of microhemorrhage (MH) and other imaging features such as size of lesion, cystic features and pattern of IAC extension, were evaluated as a tool in distinguishing VS from other CPA masses. A review of CPA masses in the last 11 years at our institution was performed. All the pathology proven tumors with at least 1 pre-operative MRI were considered for analysis. A T2* GRE or SWI sequence was used to assess presence of MH within the lesion. Pattern of IAC extension ('centric' versus 'eccentric') of tumor was also evaluated. A total of 147 patients were reviewed out of which 102 patients (with T2* GRE or SWI) wer e included for analysis of MH. 57 patients (56%) had VS as the final histopathological diagnosis and 45 patients (44%) had other types of tumor. A sensitivity of 82% and a specificity of 98% was noted for the presence of MH favoring the diagnosis of VS from other tumors (p < 0.001). All meningiomas with IAC extension (25/31) showed an 'eccentric' pattern of extension into the canal. Visualization of MH and pattern of IAC extension is useful in the differentiation of schwannomas from other CPA masses, particularly meningiomas. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Human liver umbilical fissure variants: pons hepatis (ligamentum teres tunnel).

xlomafota13 shared this article with you from Inoreader Human liver umbilical fissure variants: pons hepatis (ligamentum teres tunnel). Via radiol anat Related Articles Human liver umbilical fissure variants: pons hepatis (ligamentum teres tunnel). Surg Radiol Anat. 2021 Feb 04;: Authors: Cawich SO, Gardner MT, Shetty R, Pearce NW, Deshpande R, Naraynsingh V, Armstrong T Abstract PURPOSE: In the classical description of normal liver anatomy, the umbilical fissure is a long, narrow groove that receives the ligamentum teres hepatis. The pons hepatis is an anatomic variant, where the umbilical fissure is converted into a tunnel by an overlying bridge of liver parenchyma. We carried out a study to evaluate the existing variations of the umbilical fissure in a Caribbean population. METHODS: We observed all consecutive autopsies performed at a facility in Jamaica and selected cadavers with a pons hepatis for detailed study. A pons hepatis was considered present when the umbilical fissure was covered by hepatic parenchyma. We recognized two variants: an open-type (incomplete) pons hepatis in which the umbilical fissure was incompletely covered by parenchyma ≤ 2 cm in length and a closed type (complete) pons hepatis in which the umbilical fissure was covered by a parenchymal bridge > 2 cm and thus converted into a tunnel. We measured the length (distance from transverse fissure to anterior margin of the parenchymatous bridge), width (extension across the umbilical fissure in a coronal plane) and thickness (distance from the visceral surface to the hepatic surface measured at the mid-point of the parenchymal bridge in a sagittal plane) of each pons hepatis. A systematic literature review was also performed to retrieve data from releva nt studies. The raw data from these retrieved studies was used to calculate the global point prevalence of pons hepatis and compared the prevalence in our population. RESULTS: Of 66 autopsies observed, a pons hepatis was present in 27 (40.9%) cadavers. There were 15 complete variants, with a mean length of 34.66 mm, mean width of 16.98 mm and mean thickness of 10.98 mm. There were 12 incomplete variants, with a mean length of 17.02 mm, width of 17.03 mm and thickness of 9.56 mm. The global point prevalence of the pons hepatis (190/5515) was calculated to be or 3.45% of the global population. CONCLUSIONS: We have proposed a classification of the pons hepatis that is reproducible and clinically relevant. This allowed us to identify a high prevalence of pons hepatis (41%) in this Afro-Caribbean population that is significantly greater than the global prevalence (3.45%; P < 0.0001). PMID: 33538876 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Is Septal Cartilage Graft via Transmastoid Approach Safe Enough in the Repair of Large Tegmen Defects?

xlomafota13 shared this article with you from Inoreader Is Septal Cartilage Graft via Transmastoid Approach Safe Enough in the Repair of Large Tegmen Defects? Via O.R.L. Journal for oto-rhino-laryngology and its borderlands Introduction: Tegmen defect (TD) has a potential of intracranial spread of middle ear infection, meningoencephalic herniation (MEH), and cerebrospinal fluid leakage (CSFL). Especially the defects #x3e;1 cm with MEH or CSFL are generally repaired via the classical middle fossa or minicraniotomy technique. The aim of this study was to show the efficiency of the intracranial, extradural placement of the septal cartilage graft in the closure of the TD larger than 1 cm via the transmastoid (TM) approach. Methods: The demographic, preoperative, intraoperative, and postoperative data of 11 patients with chronic otitis media (COM) who had TD larger than 1 cm were reviewed retrospectively. Hospitalization time and hearing preservation with respect to MEH or CSFL were analyzed. Results: The most common etiology of TD was cholesteatoma (82%), and 91% of the patients had multiple COM surgery history. The mean TD size was 15.4 (10–25) mm. Fifty-fi ve percent of the patients presented with either MEH or CSFL. The mean follow-up of the patients was 22.5 (8–42) months. There was no significant difference between preoperative and postoperative mean bone conduction thresholds. Mean hospitalization time was 5.2 (3–10) days. There was no significant difference in the hospitalization time between patients with MEH or CSFL and without MEH or CSFL. Neither recurrence nor graft infection was encountered. Conclusion: Extradural grafting with the septal cartilage in the large TD up to 25 mm can be repaired efficiently via the TM approach without application of a lumbar drainage. ORL View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Pediatric nasal neuroglial heterotopia

xlomafota13 shared this article with you from Inoreader [Pediatric nasal neuroglial heterotopia: report of 13 cases]. Via Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Related Articles [Pediatric nasal neuroglial heterotopia: report of 13 cases]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Feb 03;56(2):117-123 Authors: Yang XJ, Tang LX, Wang PP, Zhang N, Sun JH, Zhang W, Ge WT Abstract Objective: To summarize clinical features and our experience of the diagnosis and treatment of pediatric nasal neuroglial heterotopia (NGH). Methods: Clinical data of 13 nasal NGH patients in Beijing Children's Hospital from August 2014 to October 2019 were retrospectively reviewed, including 9 boys and 4 girls, aged from 1 to 38 months with median age of 5 months. Radiological workups and excision of nasal NGH under general anesthesia were performed for all patients. B ultra-sound and MRI were performed for all external and mixed lesions, while ultra-low-dose CT scan and MRI for all intranasal type. Surgical approaches were dependent on location and extent of the lesions according to radiographic workup, including extranasal or transnasal endoscopic approach. Patients were followed up regularly after operation to evaluate the effect. Initial presentation, locations, imaging findings, surgical approaches and follow-up results were analyzed through descriptive statistical meth od. Results: Eight nasal NGH patients presented with an internal nasal mass and nasal obstruction, which belonged to intranasal type. Three patients presented with an external nasal mass which belonged to extranasal type and 2 patients had mixed lesions. The sites included nasal dorsum (n=5), anterior to the middle turbinate (n=5) and olfactory cleft (n=3). Surgical resections were done through median rhinotomy approach (n=5) or transnasal endoscopic approach (n=8). All the operations were successful and no complication occurred. All cases were followed up from 3 to 65 months. No recurrence was encountered. Conclusions: Nasal NGH is a rare lesion with atypical clinical presentation. Preoperative imaging including CT scan and MRI is essential for evaluation of the location, extent of the disease and for making the surgical plan. Treatment requires complete surgical excision. PMID: 33548940 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The expression of Notch pathway in nasal polyps and its correlation with the decreased Treg percentage and eosinophil infiltration

xlomafota13 shared this article with you from Inoreader [The expression of Notch pathway in nasal polyps and its correlation with the decreased Treg percentage and eosinophil infiltration]. Via Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Related Articles [The expression of Notch pathway in nasal polyps and its correlation with the decreased Treg percentage and eosinophil infiltration]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Feb 03;56(2):124-132 Authors: Li SX, Li X, Chen XH, Wu XF, Huang JC, Lai XP, Yang LY, Huang ZZ, Zhang GH, Chang LH Abstract Objective: To investigate the correlation between Notch pathway expression in nasal polyps and Treg percentage and Eos infiltration. Methods: Patients with chronic sinusitis and simple nasal septum deviation who received nasal endoscopic surgery in the Third Affiliated Hospital of Sun Yat-Sen University between November 2012 and August 2018 were selected and enrolled in CRS group and control group respectively. Nasal mucosa tissues were collected from 30 CRSsNP patients (14 males and 16 females aged from 18 to 63), 58 CRSwNP patients (38 males and 20 females aged from 18 to 65) and 29 patients (19 males and 10 females aged from 20 to 57), who underwent nasal endoscopic surgery for correction of simple nasal septum deviation. Hematoxylin-eosin(HE) staining was used to observe the infiltration of eosinophilic granulocytes in the tissues and to classify chronic sinusitis with polyps (CRSwNP) into eosinophilic chronic rhinosinusitis with nasal polyps (Eos-CRSwNP)and non-eosinophi lic chronic rhinosinusitis with nasal polyps (Eos-CRSwNP). Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of Notch pathway receptors (Notch-l, 2, 3, 4) and their ligands (Jagded-l, Jagded-2, Delta-l, Delta-3and Delta-4) in the nasal mucosa of each group, as well as the expression of Th2 cytokines (IL-4, IL-5, IL-13), eosinophilic cationic protein (ECP)and the key transcription factor Foxp3 in Treg cells. Finally, flow cytometry was used to detect CD4+CD25+Foxp3+ Treg cells in nasal mucosa of each group. Results: Compared with controls, the expression of Th2 cytokines (IL-4, IL-5, IL-13) in CRSsNP and non-Eos-CRSwNP patients was the highest in Eos-CRSwNP (F=16.930,9.197,9.116, all P<0.05). Foxp3 had the lowest expression in Eos-CRSwNP patients and was lower than non-Eos-CRSwNP patients (F=2.780,P<0.05), and was negatively correlated with ECP (r=-0.326,P<0.05). Compared with controls, Eos-CRSwNP patients in CRSsNP patients and non -Eos-CRSwNP patients exhibited a significantly lower frequency of CD4+CD25+Foxp3+Treg cells (F=13.140, all P<0.01). The expression of Notch-l and Jagged-l in Eos-CRSwNP was significantly higher than that of the controls, CRSsNP patients and non-Eos-CRSwNP patients (F=5.953/F=6.380, P<0.05). In the nasal polyp group, the expression of Notch-l and Jagged-l showed significantly negative correlation with Foxp3 (r=-0.611/-0.346, all P<0.05), and positive correlation with Th2 cytokines (IL-4, IL-5, IL-13) and ECP, respectively (r=0.781/0.459,0.621/0.601,0.605/0.490,0.464/0.668, all P<0.05). There was no significant difference in the expression of receptor and ligand of the other Notch pathway among the groups. Conclusion: Abnormal activation of Notch-l/Jagged-l pathway may be involved in decreasing Treg ratio in Eos-CRSwNP, thereby promoting Th2 inflammatory response and Eosinophil infiltration. PMID: 33548941 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

DNA double-strand breaks repair capacity and risk of differentiated thyroid cancer

xlomafota13 shared this article with you from Inoreader [DNA double-strand breaks repair capacity and risk of differentiated thyroid cancer: a case-control study]. Via Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Related Articles [DNA double-strand breaks repair capacity and risk of differentiated thyroid cancer: a case-control study]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Feb 03;56(2):133-137 Authors: Qin JL, Shi XY, Fan J, Liu ST, Li G, Wu JF, Zhang M Abstract Objective: To study the influencing factors of DNA double-strand breaks (DSB) repair capacity and relationship with differentiated thyroid cancer (DTC). Methods: A total of 140 patients with thyroid diseases admitted to the Henan Cancer Hospital from January 2020 to March 2020 were retrospectively analyzed, including 26 males and 114 females, aged from 18 to 78 years old. According to the pathological results, the patients were divided into DTC group (90 cases) and control group or benign thyroid nodules (BTN) group (50 cases). The DSB repair ability of peripheral blood T lymphocytes was measured by flow cytometry. The data of two groups were compared by Wilcoxon rank sum test to evaluate the relationship between DSB repair ability and the risk of DTC. According to the median repair ability of DSB in BTN group, the repair ability of DSB was divided into high and low categories, and the factors influencing the repair ability of DSB were analyzed by Logistic regression method. SPSS 22.0 software was used to analyze the data. Results: The DSB repair capacity was 27.87% in DTC group and 36.75% in BTN group, with significant difference (Z=-3.999,P<0.05). Logistic regression analysis suggested that patients with thyroid cancer had lower DSB repair capacity than patients without cancer (OR=2.245; 95%CI: 1.067-4.725; P=0.033), and patients with a history of radiation exposure had a reduced DSB repair capacity (OR=2.698; 95%CI: 1.271-5.725, P=0.010). Conclusion: The risk of DTC increases in patients with low DSB repair capacity. Radiation exposure is a risk factor for the reduction of DSB repair capacity. PMID: 33548942 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Goldengate high-throughput deafness gene chip in detecting the patients with enlarged vestibular aqueduct syndrome

xlomafota13 shared this article with you from Inoreader [Validation and analysis of Goldengate high-throughput deafness gene chip in detecting the patients with enlarged vestibular aqueduct syndrome]. Via Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Related Articles [Validation and analysis of Goldengate high-throughput deafness gene chip in detecting the patients with enlarged vestibular aqueduct syndrome]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Feb 03;56(2):138-143 Authors: Wu H, Jiang L, Liu C, Liu YL, Long MQ, Mei LY, He CF, Cai XZ, Chen HS, Feng Y Abstract Objective: To verify the accuracy and effectiveness of Goldengate high-throughput deafness gene chip in detecting the patients with enlarged vestibular aqueduct syndrome(EVAS), and to provide a reference for genetic detection strategy of EVAS. Methods: From August 2016 to February 2018, 15 patients with EVAS and 60 normal controls were detected by Goldengate high-throughput deafness detection chip developed by our team, and the results were verified by Sanger sequencing. SLC26A4 gene sequencing was carried out in all the patients with EVAS. Results: 12/15 of patients with EVAS were detected mutations of SLC26A4 gene. Nine mutations were detected by chip detection and SLC26A4 gene direct sequencing, seven of which were detected by both methods. The chip could detect 93.33%(28/30) of the allele information provided by SLC26A4 gene direct sequencing. In addition to SLC26A4 gene, mutations of GJB2, PCDH15, TMC1, MYO6 and mitochondrial genes were detected in 15 patients with EVAS. These results were verified by Sanger sequencing. Conclusion: Goldengate high-throughput deafness gene chip possesses the traits of wide coverage and high accuracy, which can be used as a preliminary detection method for patients with EVAS. PMID: 33548943 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hemostatic powder for chronic rhinosinusitis in endoscopic sinus surgery

xlomafota13 shared this article with you from Inoreader [The efficacy of hemostatic powder for chronic rhinosinusitis in endoscopic sinus surgery: a prospective, randomised, controlled and single blinded clinical trial]. Via Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Related Articles [The efficacy of hemostatic powder for chronic rhinosinusitis in endoscopic sinus surgery: a prospective, randomised, controlled and single blinded clinical trial]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Feb 03;56(2):144-149 Authors: Huang ZX, Qu J, Zhou YK, Li YX, Huo MR, Li C, Huang Q, Zhou B, Li YC Abstract Objective: To study the efficacy and patient comfort of absorbable hemostatic powder after endoscopic sinus surgery (ESS). Methods: A total of 21 (17 males, 4 females) patients with an average age of 42(ranging from 18 to 65) underwent bilateral ESS for chronic rhinosinusitis(CRS) in Beijing Tongren Hospital, Capital Medical University between October 2015 and July 2019 were enrolled to compare the effect of absorbable hemostasis powder with Nasopore using an intrapatient control design. A randomized controlled trial was conducted in the left and right nasal cavities of the same patient. If hemostatic powder was applied in the experiment nasal cavity, the Nasopore was applied in the control nasal cavity. The mean preoperative sinus computed tomography (CT) score was 6.25. All patients competed for symptom diaries using a visual analog scale (VAS, score out of 10) at baseline, through 1, 7, 14 and 30 days. Outcomes including bleeding, facial pain, nasal obstruction, nasal disc harges using VAS were recorded separately for both sides. Postoperative endoscopic scores were also investigated. SPSS 22 and Graphpad prism 8.0 statistical softwares were used for the analysis. Paired t-test or nonparametric test was used between the test side and the control side. The difference was statistically significant (P<0.05). Results: The bleeding score and total nasal symptom VAS scores at postoperative days (POD) 1, 7, 14 and 30 were not significantly different(t=1.341, 0.552, 0.631, 0.158, all P>0.05;t=0.944, 1.471, 1.612, 2.251, all P>0.05). There was no significant difference between absorbable hemostasis powder and Nasopore side on POD 1, 7, 14 and 30 in terms of each nasal symptom VAS scores(all P>0.05). On POD 1, 7 and 14, the packing material degeneration scores of the absorbable hemostasis powder side were significantly lower than those of the Nasopore side [(1.33±0.21)vs(2.00±0.00),(0.38±0.18) vs (1.95±0.22), 0 vs (1.80±0.13), all P<0.01]. T here were significant differences between absorbable hemostasis powder and Nasopore side on POD 1, 7, 14 and 30 in terms of endoscopic scores (edema, crusting, discharges, scar, polyps and material degeneration, t=3.07, 7.00, 6.41, 2.69, all P<0.05). Conclusions: The absorbable hemostasis powder and Nasopore has similar postoperative hemostasis effect. The absorbable hemostasis powder is rapidly cleared and without negative effects on mucosal wound healing 14 days postoperatively. PMID: 33548944 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

CAD/CAM‐based Referencing Aids to Reduce Preoperative Radiation Exposure for Intraoperative Navigation

xlomafota13 shared this article with you from Inoreader CAD/CAM‐based Referencing Aids to Reduce Preoperative Radiation Exposure for Intraoperative Navigation Via The International Journal of Medical Robotics and Computer Assisted Surgery Abstract Background All intraoperative navigation systems need a referencing procedure prior to utilization, usually requiring an additional CT or CBCT scan. As new techniques in the field of CAD/CAM have evolved, it seemed favorable to develop a new referencing method not relying on additional CT or CBCT scans. Methods A digital maxillary dental scan was used to create a referencing splint by CAD/CAM containing four reference points. By matching scanned dental model and initial trauma‐CT, the splints position and thus the reference points were digitally simulated. These splints STL data was imported into the navigation system. This data was also 3D printed and the resulting piece was placed on the anatomical models' teeth. The methods accuracy was then assessed in vitro. Conclusion Our method for referencing of intraoperative navigation can be feasible to avoid an additional CT or CBCT prior to navigation. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Effects of Manual Therapy in Somatic Tinnitus Patients Associated with Cervicogenic and Temporomandibular Dysfunction Domain: Systematic Review and Meta Analysis of Randomised Controlled Trials

xlomafota13 shared this article with you from Inoreader Effects of Manual Therapy in Somatic Tinnitus Patients Associated with Cervicogenic and Temporomandibular Dysfunction Domain: Systematic Review and Meta Analysis of Randomised Controlled Trials Via Otolaryngology Indian Abstract Despite manual therapy has been used as an effective treatment but there is limited of literature emphasizing its role to improve quality of life and pain pressure threshold in patients with somatic tinnitus. In this Meta analysis we compared the effects of manual therapy on quality of life and pain pressure threshold in the patients with somatic tinnitus associated with cervicogenic and temporomandibular dysfunction domain. We systematically searched different databases such as Pubmed, Google Scholar and Scopus to find out the relevant studies compairing the effects of manual therapy with quality of life and pain pressure threshold. Two independent reviewers performed quality check and data extraction. We analyzed the data using RevMan ver. 5.4 software. Total three randomised controlled trials were included in this study. Manual Therapy proven to be effective in improving quality of life as well pain pressure threshold in somatic tinnitus patients. {ORs 0.80; 9 5% Confidence Interval (95%CI), P = 0.97}. Further clinical trials are needed to explore manual therapy as an effective intervention. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Auricular Cartilage Graft, An Alternative for Bony Palatal Defect? A Case Report

xlomafota13 shared this article with you from Inoreader Auricular Cartilage Graft, An Alternative for Bony Palatal Defect? A Case Report Via Otolaryngology Indian Abstract A 51 year old male patient reported with a chief complaint of nasal regurgitation of fluids since a period of 1 year. Patient was operated once earlier with soft tissue palatal closure following which there was recurrence of symptoms. In this case, the defect was managed with an auricular cartilage graft followed by palatal mucosal closure. The healing was uneventful till the latest follow-up. Rationale of this case report lies in its approach to manage an oronasal communication which recurred following a soft tissue closure. Various management strategies have been applied in literature which included grafts, alloplastic materials and vascular free tissue transfer. Following informed and written consent, Patient was operated under General Anaesthesia and was observed for a follow-up period of 2 years. There was uneventful healing along with improvement in patient's phonation and diet. Complete resolution of nasal regurgitation was achieved. The a uricular cartilage graft used for reconstruction in this case is comparatively less invasive and provides an additional advantage of a double layered closure. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.