Massive hemothorax resulting from a minor injury mechanism is considered to be rare particularly when the diaphragm is injured. We report a case of massive hemothorax with bleeding from the intercostal artery ...
https://ift.tt/2pG3jzB
Σάββατο 6 Οκτωβρίου 2018
Massive hemothorax due to two bleeding sources with minor injury mechanism: a case report
Innate immunosensing of DNA in cellular senescence
Selene Glück | Andrea Ablasser
https://ift.tt/2OLT23i
SAMHD1 and the innate immune response to cytosolic DNA during DNA replication
Flavie Coquel | Christoph Neumayer | Yea-Lih Lin | Philippe Pasero
https://ift.tt/2PgZGvh
Control of autoreactive B cells by IgM and IgD B cell receptors: maintaining a fine balance
Mark Noviski | Julie Zikherman
https://ift.tt/2Pp7rz6
Use of Recombinant Human Bone Morphogenetic Protein-2 Associated With Lyophilized Bovine Bone in Reconstruction of Atrophic Maxilla
Cases of severely atrophic edentulous maxilla require reconstruction techniques employing bone grafts to promote adequate bone dimension for the successful placement of dental implants for prosthetic rehabilitation that reestablishes the patient's function and aesthetics. This study aims to present a severely atrophic edentulous maxilla reconstruction with the off-label use of recombinant human bone morphogenetic protein type 2 (rhBMP-2) associated with lyophilized particulate bovine bone xenograft for the prosthetic rehabilitation with osseointegrable dental implants. The paper describes a case of severely atrophic edentulous maxilla in a 42-year-old woman referred to the dental school with complaint of failure in adaptating to the dentures. The patient reported 27 years of maxilla edentulism and consecutive treatment failures, so the proposed therapy was the reconstruction of the maxilla with an association of rhBMP-2 and lyophilized bovine bone xenograft for increasing bone volume and further prosthetic rehabilitation with osseointegrated dental implants. The present report illustrates a case of atrophic edentulous maxilla in which the off-label use of rhBMP-2 was successful and the patient's prosthetic rehabilitation could be concluded. The 8 dental implants received prosthetic functional load during 1 year of follow-up with no complications. Based on the case presented, the association between rhBMP-2 and a bovine bone xenograft could be considered a viable option for the reconstruction of atrophic edentulous maxilla. After a year of functional prosthetic load follow-up, the patient is asymptomatic and satisfactorily adaptated to the prosthesis, which restored her functional and aesthetic demands.https://ift.tt/2II1M50
The Quality of Scholarly Published Material Based on Education is our Business in the Worldwide Information World
No abstract availablehttps://ift.tt/2CtaKm7
Fibrous Dysplasia: A Complex Maxillary Reconstruction
Fibrous dysplasia is a benign tumor of the skeleton. Mostly 2 forms are described: a monostotic and a poliostotic form. The maxilla and the mandible are the most interested of the facial district. The authors report a patient of a huge maxillary fibrous dysplasia. A 63-year-old patient was treated for a 20-year progressive left maxillary neoformation. A total maxillectomy was performed. The defect was reconstructed with a custom-made midface implant associated with a temporal and a pericranial flap.https://ift.tt/2II1JpQ
The Mystery of the Vestibular Labyrinth, a Family Passion
No abstract availablehttps://ift.tt/2CtaIL1
Intraoral Anastomosis of Deep Circumflex Iliac Artery Perforator Flap for Maxillary Reconstruction
Maxillary reconstruction is one of the most challenging areas of reconstructive surgery. This report describes a case of a 33-year-old male with osteoblastic osteosarcoma of the maxillary. The patient received radical resection and reconstruction with a deep circumflex iliac artery perforator flap (DCIAPF). The flap was harvested with a 4 × 2 cm2 osseous flap and a 6 × 8 cm2 skin island supplied by terminal perforators from the deep circumflex iliac artery. Anastomosis was accomplished on the ipsilateral facial vessels with deep circumflex iliac vessels through an intraoral approach. The donor site and the flap were observed to have completed primary healing 2 weeks after the surgery. The DCIAPF may be a satisfactory single-flap option for maxillary reconstruction with less donor-site complications.https://ift.tt/2IMEI5b
Complex Orbital Fractures: Three-Dimensional Planning and Combined Surgical Approach
Nowadays the development of diagnostic imaging, surgical techniques, alloplastic materials, and surgical instruments has made possible a more accurate management of orbital fractures. The aim of the present study was the management of orbital fractures and the solution of particular cases. The use of high-resolution computed tomography makes possible to gain a better understanding of the complex orbit anatomical structure. Also endoscopy is a valid alternative for medial orbital wall fractures treatment. It gives high control of the fracture site and its reduction. When this technology is combined with 3-dimensional (3D) reformatted images, it allows us to reconstruct more accurately the orbital defects. The authors present their experience in complex orbital fractures treated with the aim of the 3D navigation using a preformed orbital titanium plate. Endosopical approach was used to control plate positioning.https://ift.tt/2IHaTTv
Did Anton Raphael Mengs Suffer From a Vascular Malformation?
No abstract availablehttps://ift.tt/2CtaAv1
Palatal Wiring: Renewing an Old Technique (Circumpalatal Wiring)
Circumpalatal wiring has 2 negative points. The first is premature loosening of the wire and the second is tongue irritation caused by exposed wire in roof of the mouth. In this article, a modified technique (palatal wiring) is introduced in which these 2 problems are targeted. In this technique, a small bur hole is created into the hard palate, without the need for flap reflection and wire is passed through it, grasps in the nose, and returns to the oral cavity via sublabial puncture point then 2 ends are twisted in labial vestibule. Palatal wiring can be used alone or as an aid to firmly secure arch bar.https://ift.tt/2II1wD4
The SOBRAPAR Hospital Craniofacial Surgery Fellowship: Wide Craniofacial Surgery Training Based on Historical and Evolving Principles
No abstract availablehttps://ift.tt/2CtaxPR
Lingual Nerve Entrapment in Fused Submandibular and Sublingual Salivary Glands: A Unique Finding
Lingual nerve (LN) is one among the 3 branches of posterior division of mandibular nerve. It might get entrapped in the infratemporal fossa by lateral pterygoid muscle, pterygospinous ligament, or lateral pterygoid plate. Its entrapment in the submandibular region has not been reported yet. A unique entrapment of LN in the fused submandibular and sublingual salivary glands in a cadaver was reported. The deep parts of the submandibular and sublingual salivary glands were completely fused with each other. The LN passed through the center of the fused part. Histologically both submandibular and sublingual salivary glands had both mucous and serous acini. Though this entrapment might not cause any functional problems, it might get injured during various surgical procedures of the submandibular region.https://ift.tt/2II1tXU
The Promising Effects of Transplanted Umbilical Cord Mesenchymal Stem Cells on the Treatment in Traumatic Brain Injury
Many studies have reported the recovery ability of umbilical cord-derived mesenchymal stem cells (UC-MSCs) for neural diseases. In this study, the authors explored the roles of UC-MSCs to treat the traumatic brain injury. Umbilical cord-derived mesenchymal stem cells were isolated from healthy neonatal rat umbilical cord immediately after delivery. The traumatic brain injury (TBI) model was formed by the classical gravity method. The authors detected the behavior changes and measured the levels of inflammatory factors, such as interleukin-lβ and tumor necrosis factor-α by enzyme linked immunosorbent assay (ELISA) at 1, 2, 3, 4 weeks after transplantation between TBI treated and untreated with UC-MSCs. Simultaneously, the expression of glial cell line-derived neurotrophic factor (GDNF) and brain derived neurotrophic factor (BDNF) were measured by real-time–polymerase chain reaction and ELISA. The authors found that the group of transplantation UC-MSCs has a significant improvement than other group treated by phosphate buffered saline. In the behavioral test, the Neurological Severity Scores of UC-MSCs + TBI group were lower than TBI group (P https://ift.tt/2CuudTz
Effect of Navigation System on Removal of Foreign Bodies in Head and Neck Surgery
Foreign bodies retained in oral and maxillofacial regions include different types and properties. Road traffic accident is one of the major causes of the maxillofacial trauma. Foreign bodies can cause direct or indirect damage to the body, even life-threatening. It is a demanding procedure to detect the accurate position and implement surgical removal of the embedded fragments in the soft tissue in clinic. Usually, foreign bodies are close to important structures such as the head and neck region with limited intraoperative visibility and anatomical intricacies. Therefore, the key to remove foreign bodies in head and neck surgery is precise localization and reasonable surgical approaches. The authors reported that the foreign bodies adjacent to large vessels in a case were successfully removed assisted by AccuNavi-A surgical navigation system.https://ift.tt/2IHaHnf
Resorbable Material for Pediatric Orbital Floor Reconstruction
Introduction: The use of resorbable materials is becoming more popular for pediatric orbital floor reconstruction. The purpose of this systematic review is to evaluate the effectiveness and safety of the various materials used in pediatric orbital floor reconstruction. Methods: A systematic literature search was performed to identify all relevant articles reporting complications following pediatric orbital floor reconstruction. The search included published articles in three electronic databases—Ovid MEDLINE, EMBASE, and PubMed starting from database establishment to July 2017. Primary endpoints were enophthalmos, diplopia, and infection. Resorbable material was compared to autologous grafts and nonresorbable material. Results: A total of 14 studies containing 248 patients were included in this review. Fifty-four (21.8%) patients had reconstruction performed with autologous grafts, 72 (29.0%) patients with resorbable material, and 122 (49.2%) patients with nonresorbable material. Resorbable materials had the lowest rate of postoperative enophthalmos (3/52; 5.8%) and the highest rate of postoperative diplopia (19/72; 26.4%). In contrast, nonresorbable materials had the lowest rate of postoperative diplopia (5/122; 4.1%), the highest rate of postoperative enophthalmos (14/102; 13.7%). Autologous reconstruction was associated with an 11.1% (4/36) rate of postoperative enophthalmos and a 22.2% (12/54) rate of postoperative diplopia. Nine cases (8.8%) of postoperative infection were documented with nonresorbable materials. No cases of infection were reported with autologous grafts or resorbable materials. Conclusion: Newer resorbable implants are safe and have a similar complication profile as traditional autologous grafts in pediatric orbital floor reconstruction.https://ift.tt/2CsGbNH
A Simple and Reliable Submental Intubation Technique for Maxillofacial Fractures
In 1986, Altemir first reported the use of submental intubation to avoid tracheotomy in patients with panfacial and midfacial fractures for whom intermaxillary fixation is necessary, but orotracheal and nasotracheal intubations are not recommended. This novel technique allowed intraoperative access to perform dental occlusion and reconstruction of the nasal pyramid in patients with skull base fractures. Herein, we describe a refined technique based on Altemir's original procedure. Seven male patients with panfacial fractures underwent submental intubation using our refined technique. The technique was developed after encountering a technical error with Altemir's original procedure. In this new technique, we employed a 2-0 silk suture guide to allow the passage of both the endotracheal and cuff-inflation tubes through the same tunnel created from the oral cavity to the submental area. The success rate of the refined technique was 100%, and there were no intraoperative or postoperative complications. There was 20 seconds of ventilation outage time in total. Endotracheal and cuff-inflation tubes were easily and quickly passed through the same submental tunnel. Our refined technique is simple, easy, safe, fast, inexpensive, and does not require specific materials. Submental scars were smaller and relatively inconspicuous in this study, compared to those reportedly associated with other modified techniques.https://ift.tt/2IJftQS
Persistent Opioid Use Among Children, Adolescents, and Young Adults After Common Cleft Operations
Background: Surgical care represents an important source of opioid prescribing and chronic use, but rates of prolonged opioid use following pediatric procedures remain unclear. The authors describe the rates and risk factors for new persistent opioid use in patients after common cleft operations. Methods: The authors examined claims from the Truven Marketscan databases from January 1, 2010 to December 31, 2014. The authors included opioid-naive patients ages 8 to 25, who underwent 1 of 10 cleft-related procedures. Patients were considered opioid-naïve if they had no opioid prescription fills in the 11 months prior to the perioperative period. The authors obtained a random sample of age-matched, nonsurgical patients from the same dataset to be used as a control group. Included cleft patients had no procedural codes in the 6 months following surgery. All included patients filled an opioid prescription during the perioperative period, defined as 30 days before and 14 days after surgery. The primary outcome was new persistent opioid use, which is defined as continued opioid prescription fills between 90 and 180 days after the procedure. Results: This cohort included 2039 cleft patients and 2100 control patients. The incidence of new persistent opioid use following surgery was 4.4% and 0.1% in the control group. Higher odds of opioid use 3 months beyond surgery were associated with distractor placement (OR 5.34, CI 2.00–14.24, P = 0.001). Increasing age (OR 1.11, CI 1.04–1.17, P = 0.001) and presence of a gastrointestinal comorbidity (OR 7.37, CI 1.49–36.54, P = 0.014) were also associated with new persistent use. Conclusions: New persistent opioid use occurs after cleft-related procedures and could lead to chronic use in children, adolescents, and young adults.https://ift.tt/2CtamEb
Porcine Bone Incorporated With 4-Hexylresorcinol Increases New Bone Formation by Suppression of the Nuclear Factor Kappa B Signaling Pathway
Objective: The objectives of this study were to evaluate the suppression of the nuclear factor kappa B (NF-kB) pathway by 4-hexylresorcinol (4HR), which was activated by tumor necrosis factor-α (TNF-α) in osteoblasts, and new bone formation by 4HR-incorporated porcine bone in an animal model. Study Design: For the confirmation of successful incorporation of 4HR into porcine bone, scanning electron microscopy (SEM) and Fourier transform-infrared (FT-IR) analysis were performed. High performance liquid chromatography was performed for the analysis of the 4HR release profile from porcine bone. MC 3T3-E1 cells were used for the analysis of the NF-kB signaling pathway activation by western blotting and real-time reverse transcriptase polymerase chain reaction. New bone formation and the analysis of marker protein expression were studied in a rat calvarial critical-sized defect model. Results: Both SEM and FT-IR analysis demonstrated successful incorporation of 4HR into porcine bone. Approximately 30% of 4HR was steadily released from porcine bone for 18 days. 4HR suppressed the NF-kB signaling pathway, which was activated by TNF-α application in MC 3T3-E1 cells. Histological analysis revealed that porcine bone particles with incorporated 4HR showed significantly greater new bone formation than those without 4HR at 4 and 8 weeks after operation (P https://ift.tt/2IFr8Ae
Surgical Management of Mandibular Angle Fractures
Purpose: The study proposed to determine the superiority between different fixation methods in the mandibular angle fractures (MAFs) and to evaluate best option for surgeon and patient. Methods: A systematic review was conducted according to PRISMA guidelines, examining Medline-Ovid, Embase, and Pubmed databases. The quality of studies was assessed, and the odds risk (OR) with its corresponding 95% confidence interval (CI) was assessed to measure the effect size. Subgroup analyses by different fracture regions and different miniplate sizes were performed. Publication bias was measured by a funnel plot. Results: Twenty-one articles were enrolled in this review: 8 randomized controlled trials , 2 controlled clinical trials, and 11 retrospective studies. There were significant advantages for 3-dimensional (3D) miniplate (OR = 0.48, P = 0.003, 95% CI, 0.35–0.67) and 1 miniplate (OR 0.38, 95% CI 0.25–0.58, P https://ift.tt/2CtainV
Impact of endodontic post material on longitudinal changes in interproximal bone level: a randomized controlled pilot trial
Abstract
Objectives
Aim was to evaluate the impact of glass fiber versus titanium endodontic posts on the interproximal bone level around severely damaged endodontically treated teeth.
Materials and methods
Thirty-eight participants of a randomized controlled trial on glass fiber (n = 18) and titanium post-endodontic restorations (n = 20) received radiographs at two different times after post placement (T0 = <12 months and T1 = 36–72 months after post placement). A total of 76 radiographs were analyzed with an image-editing software. Medians of changes in mesial and distal interproximal bone level (∆MBL, ∆DBL) were calculated and tested for statistical significance with respect to post material using Mann-Whitney U test (p < 0.05). Impact of post material on bone level changes was assessed in multilevel mixed-effect linear regression models.
Results
The mean observation period was 54 months for glass fiber and 50 months for titanium posts. Interproximal bone loss was small in both groups during the study period with no significant differences between groups (glass-fiber group, ∆MBL = − 0.03 mm and ∆DBL = − 0.06 mm; titanium group, ∆MBL = − 0.07 mm and ∆DBL = − 0.17 mm; both p > 0.05). Overall, impact of post material on bone loss was almost negligible with a nonsignificant difference between materials of 0.10 mm during the entire study period.
Conclusion
The rigidity of endodontic post material has no impact on the level of alveolar bone support of severely damaged endodontically treated teeth.
Clinical relevance
Post-endodontic restorations of severely damaged teeth can achieve steady levels of periodontal bone support as a parameter of periodontal health, irrespective of post material.
https://ift.tt/2PekDXO
Algorithm for the treatment of oral and peri-oral defects through local flaps
Local flaps are currently considered the main reconstructive option for medium-size oral and peri-oral defects; however, their indications are sometimes challenging to select. The aim of this study was to critically analyse their selection and to propose a therapeutic algorithm.
https://ift.tt/2QvtiFp
Five decades of orofacial cleft management and research in Brazil
Our research team read with interest the article by Best et al.1 regarding short-term surgical missions for the management of orofacial clefts (OFCs) in South America. We congratulate the authors, but wish to make some observations. The authors stated that Chile has the only health system in South America with government-guaranteed access to surgical care for OFCs, and that the other countries on the continent are left to depend on temporary international or national campaigns or short-term surgical missions.
https://ift.tt/2Pj2OXo
Micron-scale crack propagation in laser-irradiated enamel and dentine studied with nano-CT
Abstract
Objectives
The aim of this study was to see the effect of Er:YAG laser irradiation in dentine and compare this with its effect in enamel. The mechanism of crack propagation in dentine was emphasised and its clinical implications were discussed.
Materials and methods
Coronal sections of sound enamel and dentine were machined to 50-μm thickness using a FEI-Helios Plasma (FIB). The specimen was irradiated for 30 s with 2.94-μm Er:YAG laser radiation in a moist environment, using a sapphire dental probe tip, with the tip positioned 2 mm away from the sample surface. One of the sections was analysed as a control and not irradiated. Samples were analysed using the Zeiss Xradia 810 Ultra, which allows high spatial resolution, nanoscale 3D imaging using X-ray computed tomography (CT).
Results
Dentine: In the peritubular dentine, micro-cracks ran parallel to the tubules whereas in the inter-tubular region, the cracks ran orthogonal to the dentinal tubules. These cracks extended to a mean depth of approximately 10 μm below the surface. On the dentine surface, there was preferential ablation of the less mineralised intertubular dentine, and this resulted in an irregular topography associated with tubules.
Enamel: The irradiated enamel surface showed a characteristic 'rough' morphology suggesting some preferential ablation along certain microstructure directions. There appears to be very little subsurface damage, with the prismatic structure remaining intact.
Conclusions
A possible mechanism is that laser radiation is transmitted down the dentinal tubules causing micro-cracks to form in the dentinal tubule walls that tend to be limited to this region.
Clinical relevance
Crack might be a source of fracture as it represents a weak point and subsequently might lead to a failure in restorative dentistry.
https://ift.tt/2DZ9yIO
How neuraxial labor analgesia differs by approach: dural puncture epidural as a novel option
Abstract
Background and aim
Neuraxial analgesia techniques are not limited to just standard epidural and CSE blocks. A novel approach called dural puncture epidural (DPE) which is a modification of CSE in terms of practice has gained popularity after its description and use in the obstetric population. The aim of this review is to address the practice of DPE technique as a novel option by reviewing its benefits as well as side and/or adverse effects and to understand how neuraxial labor analgesia differs by approach based on the information available in the current literature
Discussion
Despite controversies and concerns, more rapid onset of analgesia, early bilateral sacral analgesia, lower incidence of asymmetric block and fewer maternal and fetal side effects are provided with DPE when compared to epidural.
Conclusion
DPE offers a favorable risk–benefit ratio for management of neuraxial analgesia as a novel option.
https://ift.tt/2BXteu5
Retentive force of PEEK secondary crowns on zirconia primary crowns over time
Abstract
Objectives
The purpose of the present study was to evaluate the retentive forces of CAD/CAM-fabricated polyetheretherketone (PEEK) secondary crowns on zirconia primary crowns over an artificial aging period representing 10 years of clinical service and compare them to electroformed secondary crowns made from pure gold.
Material and methods
Implant-supported zirconia primary crowns (N = 20) were CAD/CAM milled and provided either with electroformed secondary crowns (group ZE; N = 10) or CAD/CAM-fabricated PEEK secondary crowns (group ZP; N = 10). All secondary crowns were attached to a casted tertiary structure to ensure adequate stability. A universal testing machine was used to determine the retentive force values at baseline and after 1, 3, 5, and 10 years of simulated aging in the presence of artificial saliva. Data were analyzed applying Kolmogorov-Smirnov, Kruskal-Wallis, and Mann-Whitney U test. Level of significance was set at p < 0.05.
Results
Retentive forces were not different for the groups ZE and ZP at baseline (median ZE 2.85 N; ZP 2.8 N; p ≤ 0.218). Because retentive force values changed significantly over simulation time for group ZE (Kruskal-Wallis; p ≤ 0.028), the values between the test groups ZE and ZP differed significantly (Mann-Whitney U) at 5 years (ZE 3.03 N; ZP 2.76 N; p ≤ 0.003) and 10 years (ZE 3.1 N; ZP 2.78 N; p ≤ 0.011).
Conclusions
PEEK secondary crowns exhibit stable retentive force values over 10 years of simulated aging showing no signs of deterioration while the retentive force values of electroformed secondary crowns increase over time.
Clinical relevance
PEEK might be a suitable alternative to proven metallic materials for the fabrication of secondary crowns.
https://ift.tt/2OFfBXa
Effect of EDTA root conditioning on the outcome of coronally advanced flap with connective tissue graft: a systematic review and meta-analysis
Abstract
Objectives
CAF in combination with a connective tissue graft (CTG) is considered the technique of choice for treating gingival recessions (GRs). Among the many recognized factors that can affect the outcomes, the use of chemical agents has been proposed. The effect of EDTA, as a commonly used agent, remains controversial. Therefore, the aim of this review was to assess the efficacy of EDTA root conditioning when combined to CAF + CTG.
Material and methods
A literature search was conducted to identify randomized clinical trials (RCTs) that performed CAF + CTG with and without EDTA for root coverage procedures. The following outcomes were assessed: recession reduction (Rec Red), complete root coverage (CRC), keratinized tissue gain (KT gain), clinical attachment level changes (CAL gain), and changes in pocket depth (PD changes).
Results
Fourteen RCTs (575 GRs) were included and analyzed. Six articles were included in the EDTA group, with 8 in the non-EDTA group. Meta-analyses revealed statistically significant differences for the outcomes of Rec Red (3.68 mm versus 3.07 mm), CAL gain (4.15 mm versus 3.07 mm), and PD changes (− 0.44 mm versus 0.27 mm) in favor of the EDTA group, while outcomes of CRC (odds ratio of 1.15) and KT gain (1.98 mm versus 1.62 mm) were not significantly different.
Conclusions
Limited evidence is available when evaluating the effectiveness of EDTA root conditioning with CAF + CTG. However, the adjunct application of EDTA with CAF + CTG appears to be beneficial.
Clinical relevance
The adjunct application of EDTA may provide benefits when performing root coverage procedure via CAF + CTG.
https://ift.tt/2E1QpWB
The internal nasal valve: a validated grading system and operative guide
Abstract
Purpose
Nasal obstruction is a highly subjective and commonly reported symptom. The internal nasal valve (INV) is the rate limiting step to nasal airflow. A static INV grading score was devised with regard to visibility of the middle turbinate.
Methods
A prospective study of all patients who underwent primary external functional septorhinoplasty in 2017 for nasal obstruction. All patients' INV score was assessed pre- and postoperatively in a blinded and independent fashion by surgeons of varying seniority.
Results
Twenty-eight patients were studied, with mean age 30.9 years and follow-up 18.8 weeks. Inter-rater and test–retest reliability of INV grading were excellent, with Cronbach's alpha 0.936 and 0.920, respectively. There was also statistically significant improvement in both subjective and objective postoperative outcome measures including nasal inspiratory peak flows.
Conclusions
We demonstrate a novel, easy to interpret, clinically valuable grading system of the static internal nasal valve that is reliable and reproducible.
https://ift.tt/2BZJ2fQ
Algorithm for the treatment of oral and peri-oral defects through local flaps
Publication date: Available online 6 October 2018
Source: Journal of Cranio-Maxillofacial Surgery
Author(s): Lara Valentina Comini, Giuseppe Spinelli, Giuditta Mannelli
Summary
Objective
Local flaps are currently considered the main reconstructive option for medium-size oral and peri-oral defects; however, their indications are sometimes challenging to select. The aim of this study was to critically analyse their selection and to propose a therapeutic algorithm.
Methods
We performed a search on Pubmed regarding the medium-size oral and peri-oral defects reconstruction and we collected data on the aetiology, the location of the defect, the type of flap used and postoperative complications. The final proposed treatment algorithm was the product of this analysis.
Results
We found 111 articles and 2504 flaps (236 buccinator flaps, 60 masseter flaps, 466 facial artery myomucosal flaps, 285 tongue flaps, 95 palatal flap, 525 buccal fat pad flaps and 835 local lip flaps). The most frequent defect's localizations included floor of mouth (203 flaps), cheek (242 flaps), anterior hard palate (418 flaps) and upper and lower lip (274 and 559 flaps). Partial flap necrosis and dehiscence occurred in 3% of cases whereas total necrosis in 1%.
Conclusions
Local flaps are a good option for oral and perioral defects reconstruction. An appropriate choice of the flap to be used based on the location of the defect is essential for a correct reconstruction.
https://ift.tt/2pEiE3D
Role and Mechanism of the Nod-Like Receptor Family Pyrin Domain-Containing 3 Inflammasome in Oral Disease
Publication date: Available online 6 October 2018
Source: Archives of Oral Biology
Author(s): Kejia Lv, Guohua Wang, Chenlu Shen, Xia Zhang, Hua Yao
Abstract
Objective
To summarize evidence and data from experimental studies regarding the role and mechanism of the Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in the pathogenesis of several representative oral diseases.
Materials and methods
A literature search of PubMed and EBSCO was performed. The literature was searched using a combination of keywords, e.g., NLRP3 inflammasome, inflammation, microorganisms, oral inflammatory diseases, and oral immunological diseases.
Results
The initiation and activation of the NLRP3 inflammasome are associated with the pathogenesis and progression of several representative oral diseases, including periodontitis, oral lichen planus, dental pulp disease, and oral cavity squamous cell carcinoma.
Conclusions
The NLRP3 inflammasome plays a crucial role in the progression of inflammatory and adaptive immune responses. The possible role of the NLRP3 inflammasome in several oral diseases, including not only periodontitis and pulpitis but also mucosal diseases and oral cavity squamous cell carcinoma, may involve the aberrant regulation of inflammatory and immune responses. Understanding the cellular and molecular biology of the NLRP3 inflammasome is necessary because the NLRP3 inflammasome may be a potential therapeutic target for the treatment and prevention of oral inflammatory and immunological diseases.
https://ift.tt/2zUotzS
Role and Mechanism of the Nod-Like Receptor Family Pyrin Domain-Containing 3 Inflammasome in Oral Disease
Publication date: Available online 6 October 2018
Source: Archives of Oral Biology
Author(s): Kejia Lv, Guohua Wang, Chenlu Shen, Xia Zhang, Hua Yao
Abstract
Objective
To summarize evidence and data from experimental studies regarding the role and mechanism of the Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in the pathogenesis of several representative oral diseases.
Materials and methods
A literature search of PubMed and EBSCO was performed. The literature was searched using a combination of keywords, e.g., NLRP3 inflammasome, inflammation, microorganisms, oral inflammatory diseases, and oral immunological diseases.
Results
The initiation and activation of the NLRP3 inflammasome are associated with the pathogenesis and progression of several representative oral diseases, including periodontitis, oral lichen planus, dental pulp disease, and oral cavity squamous cell carcinoma.
Conclusions
The NLRP3 inflammasome plays a crucial role in the progression of inflammatory and adaptive immune responses. The possible role of the NLRP3 inflammasome in several oral diseases, including not only periodontitis and pulpitis but also mucosal diseases and oral cavity squamous cell carcinoma, may involve the aberrant regulation of inflammatory and immune responses. Understanding the cellular and molecular biology of the NLRP3 inflammasome is necessary because the NLRP3 inflammasome may be a potential therapeutic target for the treatment and prevention of oral inflammatory and immunological diseases.
https://ift.tt/2zUotzS
Five decades of orofacial cleft management and research in Brazil
Publication date: Available online 6 October 2018
Source: International Journal of Oral and Maxillofacial Surgery
Author(s): J.L.G.C. Monteiro, J.A.A. de Arruda, D.F. Bueno, B.C.d.E. Vasconcelos
https://ift.tt/2OIznkw
Interferon-induced epithelial response to rhinovirus-16 in asthma relates to inflammation and FEV1
Publication date: Available online 5 October 2018
Source: Journal of Allergy and Clinical Immunology
Author(s): Abilash Ravi, Jan Koster, Annemiek Dijkhuis, Suzanne M. Bal, Yanaika S. Sabogal Piñeros, Peter I. Bonta, Christof J. Majoor, Peter J. Sterk, René Lutter
https://ift.tt/2CvFHGw
Cholestenoic Acid is a Prognostic Biomarker in Acute Respiratory Distress Syndrome
Publication date: Available online 5 October 2018
Source: Journal of Allergy and Clinical Immunology
Author(s): Jennifer H. Madenspacher, Renee D. Stapleton, Benjamin T. Suratt, Anne E. Dixon, Fred B. Lih, Julie M. Lowe, Kara J. Mould, William J. Janssen, Eric D. Morrell, Mark M. Wurfel, Stavros Garantziotis, Kenneth B. Tomer, Michael B. Fessler
https://ift.tt/2IKzyGQ
Increased surface expression of NOTCH on memory T cells in peripheral blood from asthma patients
Publication date: Available online 5 October 2018
Source: Journal of Allergy and Clinical Immunology
Author(s): Irma Tindemans, Heleen Vroman, Melanie Lukkes, Menno van Nimwegen, Marjolein J.W. de Bruijn, Bobby W.S. Li, Alex Kleinjan, Geertje M. de Boer, Gerdien A. Tramper, Mirjam Kool, Gert-Jan Braunstahl, Rudi W. Hendriks
https://ift.tt/2Csb9oU
Human TBK1 is required for early autophagy induction upon HSV1 infection
Publication date: Available online 5 October 2018
Source: Journal of Allergy and Clinical Immunology
Author(s): Liyana Ahmad, Bayarchimeg Mashbat, Corwin Leung, Charlotte Brookes, Samar Hamad, Sina Krokowski, Avinash R. Shenoy, Lazaro Lorenzo, Michael Levin, Peter O'Hare, Shen-Ying Zhang, Jean-Laurent Casanova, Serge Mostowy, Vanessa Sancho-Shimizu
https://ift.tt/2E3jGAt
Carcinogenic epithelial-mesenchymal transition initiated by oral cancer exosomes is inhibited by anti-EGFR antibody cetuximab
Publication date: November 2018
Source: Oral Oncology, Volume 86
Author(s): Toshifumi Fujiwara, Takanori Eguchi, Chiharu Sogawa, Kisho Ono, Jun Murakami, Soichiro Ibaragi, Jun-ichi Asaumi, Stuart K. Calderwood, Kuniaki Okamoto, Ken-ichi Kozaki
Abstract
Overexpression and increased signaling from the epidermal growth factor receptor (EGFR) often changes oral squamous cell carcinoma (OSCC) and thus EGFR is frequently targeted molecularly by the therapeutic antibody cetuximab. We assessed the roles of OSCC-derived extracellular vesicles (EVs), including exosomes in the trafficking of cetuximab and in epithelial-mesenchymal transition (EMT) of epithelial cells. OSCC cells abundantly expressed EGFR, which was secreted from cells with OSCC-EVs upon EGF stimulations. The OSCC-EGFR-EVs were then able to enter into and transform epithelial cells leading to increased mesenchymal traits with increased vimentin and spindle-like shapes. EGF priming of OSCC cells further increased this EMT-initiating effect of the OSCC-EVs. The internalization and pro-EMT effects of the OSCC-EVs were largely blocked by cetuximab. Thus, OSCC-derived EVs transform normal epithelial cells into a mesenchymal phenotype and anti-EGFR therapeutic antibody cetuximab inhibits such a carcinogenic effect of the OSCC-EVs.
https://ift.tt/2RxEy5g
Small cell neuroendocrine carcinoma of the alveolar process of maxilla
Publication date: Available online 5 October 2018
Source: Oral Oncology
Author(s): Muhammad Shahid Iqbal, Sarah Matthews, Anne Chambers, Charles Kelly, Omar Ahmed, James Adams
https://ift.tt/2yj6DVs
Œdème palpébral induit par le pemetrexed (Alminta®)
Publication date: Available online 5 October 2018
Source: Annales de Dermatologie et de Vénéréologie
Author(s): A. Badaoui, E. Mahé
Résumé
Introduction
Les œdèmes palpébraux induits par les médicaments sont rares. Nous rapportons une observation de patient ayant développé ce type d'œdème sous chimiothérapie.
Observation
Un homme de 56 ans consultait pour un œdème bilatéral des paupières inférieures apparu 6 mois plus tôt, après trois cycles de pemetrexed-carboplatine prescrits pour un adénocarcinome bronchique avec métastases cérébrales. L'œdème, indolore et non prurigineux, était de consistance molle et s'aggravait progressivement. En l'absence d'autre cause, le diagnostic d'œdèmes dus au pemetrexed était retenu. Compte tenu de son efficacité, et avec l'accord du patient, ce traitement était néanmoins maintenu.
Discussion
Les œdèmes palpébraux secondaires aux injections de pemetrexed sont rares ; à ce jour, seuls 22 cas en ont été rapportés dans la littérature. Il convient donc d'éliminer tous les diagnostics différentiels avant de conclure à ce diagnostic. La physiopathologie est inconnue. Certains auteurs avancent une hypothèse identique aux œdèmes sous docetaxel : fuite capillaire protéique entraînant des œdèmes cutanés et sous-cutanés et des épanchements non tumoraux. D'autres traitements tels que des inhibiteurs de tyrosine kinase (imatinib et nilotinib) ou des inhibiteurs de mTOR (sirolimus) peuvent également induire des œdèmes palpébraux. Un cas d'excision chirurgicale des tissus palpébraux lymphœdémateux a été décrit, avec un bon résultat à 6 mois de suivi.
Summary
Background
Drug-induced eyelid edemas are rare. Herein, we describe a patient who developed this type of edema under chemotherapy.
Patients and methods
A 56-year-old male patient with a history of hypertension and adenocarcinoma of the lung with brain metastases consulted for incipient non-itchy eyelid edema with progressive worsening. The swelling occurred after 3 cycles of pemetrexed-carboplatin. There was no evidence of any other cause of edema. A diagnosis of pemetrexed-induced eyelid edema was made. Given the efficacy of this treatment and the patient's consent thereto, it was maintained.
Discussion
Palpebral edemas secondary to pemetrexed are very rare, with only 22 published cases in the literature. Other differential diagnoses must be ruled out before considering this etiology. The pathogenesis of eyelid edema remains unknown. One hypothesis is capillary protein leakage inducing swelling in soft tissue and non-malignant effusion, as has been suggested for docetaxel. Other agents such as tyrosine kinase inhibitors (imatinib and nilotinib) and mTOR inhibitors (sirolimus) may also cause eyelid edema. Treatment of eyelid edema is difficult and one case of surgical treatment has been published with good results and no recurrence after 6 months.
https://ift.tt/2IHu4fY
Comorbid Conditions are a Risk for Osteonecrosis of the Jaw Unrelated to Antiresorptive Therapy
Publication date: Available online 5 October 2018
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Kenneth E. Fleisher, Malvin N. Janal, Nicole Albstein, James Young, Vanessa Bikhazi, Shlomit Schwalb, Mark S. Wolf, Robert S. Glickman
Abstract
Background: Osteonecrosis of the jaw (ONJ) is commonly associated with antiresorptive therapy. There have been numerous reports of ONJ unrelated to antiresorptive therapy (ONJuat), confounding risk assessment. This study aimed to determine if ONJuat is associated with one or more particular comorbidities.
Study Design: Retrospective case-control study for patients with ONJuat and delayed healing (DH). Each case was matched for age, gender and location of the ONJuat or DH lesion to a control who had a history of dentoalveolar surgery with uneventful healing and no history of antiresorptive therapy. Comorbidity data included medical conditions and smoking.
Results: 92 patients were identified, 67 (73%) met the criteria for the ONJuat and 25 (27%) met the criteria for DH. The most common trigger for ONJ and DH was extraction (50%). The presence of any comorbidity (i.e., at least one) was more prevalent in ONJuat than Controls (p= .04), and there were more comorbidities in ONJuat and DH patients than Controls [M(SD)= 1.94 (1.2) and 2.0 (1.3) vs 1.26 (.89); both p< .001].
Conclusions: Osteonecrosis of the jaw and delayed healing are not limited to patients with a history of antiresorptive therapy. More comorbidities may signal increased risk for ONJuat and DH.
https://ift.tt/2OEIW3T
The relationship between autophagy, increased neutrophil extracellular traps formation and endothelial dysfunction in chronic kidney disease
Publication date: Available online 6 October 2018
Source: Clinical Immunology
Author(s): Jwa-Kyung Kim, Mi Jin Park, Hoi Woul Lee, Hyung Seok Lee, Sun Ryoung Choi, Young Rim Song, Hyung Jik Kim, Hyeong-Cheon Park, Sung Gyun Kim
Abstract
In chronic kidney disease (CKD), the number of circulating neutrophils are increased, and this is usually accompanied by an increased basal activation state. However, the possible association between neutrophil extracellular traps (NETs) with vascular complications has not been evaluated. We assessed the relationship between NETs, autophagy and endothelial dysfunction in maintenance hemodialysis (MHD) patients. NET formation, neutrophil elastase (NE) activities, and serum nucleosome levels were measured in MHD (n = 60) and controls (n = 20). Basal NET formation were markedly increased in MHD patient compared to controls. After PMA stimulation, MHD neutrophils showed significantly increased NETs formation response than controls. The degree of NETs was strongly associated with lower flow-mediated dilatation(%) of brachial artery even after adjustment for cardiovascular risk factors and uremic toxins. Moreover, MHD neutrophils showed increased basal autophagy activity. Interestingly, the levels of NETs were markedly augmented after autophagy inhibition, suggesting a protective role of autophagy in excessive NET formation.
https://ift.tt/2NrBioN
Podocyte foot process width is a prediction marker for complete renal response at 6 and 12 months after induction therapy in lupus nephritis
Publication date: Available online 5 October 2018
Source: Clinical Immunology
Author(s): Kunihiro Ichinose, Mineaki Kitamura, Shuntaro Sato, Keita Fujikawa, Yoshiro Horai, Naoki Matsuoka, Masahiko Tsuboi, Fumiaki Nonaka, Toshimasa Shimizu, Shoichi Fukui, Masataka Umeda, Tomohiro Koga, Shin-ya Kawashiri, Naoki Iwamoto, Takashi Igawa, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Tomoya Nishino, Atsushi Kawakami
Abstract
Morphological change that includes diffuse effacement of podocyte foot processes is correlated with proteinuria in patients with lupus nephritis (LN). We collected the data of clinico-pathological parameters and assessed foot process width (FPW) as an index of podocyte effacement in 73 patients with LN who had undergone renal biopsy. The multivariate analysis revealed that female gender (OR: 5.288; 95%CI: 1.197–37.29; p = .0267) and FPW (OR = 0.999, 95%CI = 0.997–0.999, p = .0150) were significantly predictive of a complete renal response (CR) at 6 months, while lymphocyte counts (OR = 1.002; 95%CI = 1.001–1.003, p = .0028) and FPW (OR = 0.998, 95%CI = 0.996–0.999, p = .0027) were significantly predictive of CR at 12 months. The cut-off point determined by the Classification and Regression Trees algorithm showed that FPW <908.3 nm provides the best performance for predicting patients who achieve CR at 12 months. A smaller FPW appears to be a predictive factor for CR at 6 and 12 months after induction therapy.
https://ift.tt/2y60I6O
Fra-2 is a novel candidate drug target expressed in the podocytes of lupus nephritis
Publication date: Available online 5 October 2018
Source: Clinical Immunology
Author(s): Changliang Xu, Yunjie Miao, Qingmeng Pi, Shoucao Zhu, Furong Li
Abstract
Lupus nephritis (LN) is a common and devastating complication caused by systemic lupus erythematosus. In this study, we evaluated the expression and mechanism of Fos-related antigen 2 (Fra-2) in LN. The results showed that Fra-2 was significantly increased in kidney biopsies of LN patients compared with healthy controls and other kidney disease in glomerular podocytes. The MRL/lpr mouse strain is a murine model of lupus, and it was used to study the mechanisms of Fra-2 in LN. The results showed that Fra-2 was expressed in the glomerular podocytes. We investigated the effects of inflammatory stimuli on Fra-2 protein expression in the glomerular podocytes, and found that interferon gamma was most effective at increasing Fra-2 protein expression. Knockdown of Fra-2 using siRNA enhanced the protein expression of nephrin. Therefore, Fra-2 may be a specific drug target for podocyte injury in LN.
https://ift.tt/2NrB9BL
Usefulness of serum biopterin as a predictive biomarker for childhood asthma control: A prospective cohort study
Publication date: Available online 5 October 2018
Source: Allergology International
Author(s): Saki Kasuga, Daijiro Kabata, Tomoko Sakaguchi, Satoshi Kudoh, Satsuki Nishigaki, Yusuke Higa, Shiori Fujikawa, Hiroko Fujitani, Ayumi Shintani, Takashi Hamazaki, Haruo Shintaku
Abstract
Background
Pteridines are metabolites of tetrahydrobiopterin, which serves as co-enzyme of nitric oxide synthase. We sought to investigate the usefulness of pteridines as biomarkers for childhood asthma control.
Methods
We conducted a single-center prospective cohort study involving 168 asthmatic children aged 4–17 years who visited the periodical asthma checkup program. Serum neopterin and biopterin levels were measured as pteridines at each visit along with measurement of FeNO, respiratory function tests, nasal eosinophil test, blood eosinophil count, and IgE level. We calculated coefficients for relation between pteridines and asthma control, which was assessed by questionnaires (JPAC: Japanese Pediatric Asthma Control Program).
Results
A total of 168 participants aged 10.3 ± 3.39 years (mean ± SD) with asthma were recruited. The participants in this study contained 58 patients (34.5%) of complete-controlled based on JPAC, 132 patients (76.0%) of well-controlled group based on GINA. FeNO and serum neopterin level did not correlate with following period's JPAC scores. In contrast, serum biopterin level significantly correlated with following period's JPAC total score (Coefficients 0.398; 95% CI 0.164 to 0.632; p value 0.001) and frequency of wheezing during exercise (Coefficients 0.272; 95% CI 0.217 to 0.328; p value < 0.001).
Conclusions
We found serum biopterin effected the following period's control status of asthmatic children, thus monitoring biopterin level will be a useful for management of asthma to adjust treatment.
https://ift.tt/2E3r12R
The prevalence of otitis media in 2–3 year old Cameroonian children estimated by tympanometry
Publication date: Available online 6 October 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): John Njuma Libwea, Marie Kobela, Paul Koki Ndombo, Ritva K. Syrjänen, Heini Huhtala, Ninying Fointama, Sinata Koulla-Shiro, Hanna Nohynek, J. Pekka Nuorti, Arto A. Palmu
Abstract
Background
Acute otitis media is a common illness in children under-five years of age and associated with major health care resources in high-income countries. However, there is paucity of data on its epidemiology and clinical presentation in low-income countries. We estimated the prevalence of otitis media and assessed risk factors among children in Cameroon.
Methods
A community-based cross-sectional prevalence study of otitis media (OM) was performed on randomly selected children aged 2–3 years in Yaoundé, Cameroon from March to June 2013. OM was assessed by clinical inspection for chronic suppurative otitis media (CSOM) and tympanometry for otitis media with effusion (OME). CSOM was defined as draining of the middle ear with duration of more than two weeks and OME was defined as a flat 'type B' tympanogram.
Results
Out of 529 children enrolled in the study, 433 (56% males) subjects with available tympanograms were evaluated. Altogether, 9.7% (42/433) of children met the case definition of CSOM, OME or its complications. This consisted of 3 (0.7%) children identified with unilateral CSOM; 7 (1.6%) children with bilateral OME; 31 (7.2%) with unilateral OME and 1 (0.2%) subject with unilateral dry tympanic membrane perforation.
Logistic regression analyses showed statistically significant association between OM and parental reporting of "current symptoms of upper respiratory tract infections", Prevalence Odds Ratio (POR) = 3.71; 95% CI = 1.69–8.14).
Conclusion
As many as two out of a hundred children between the ages of 2–3 years were affected by significant middle ear disease i.e. CSOM or bilateral OME. These data could be useful as a baseline for estimating the impact of pneumococcal conjugate vaccines (PCV13) introduced in July 2011 for infants in Cameroon.
https://ift.tt/2Pgz6Ck
Angiotensin II-mediated suppression of synaptic proteins in mouse hippocampal neuronal HT22 cell was inhibited by propofol: role of calcium signaling pathway
Abstract
Purpose
Angiotensin II (Ang II) has been shown to be involved in neurological disorders. Propofol demonstrated neuroprotective effects in neurons.
Methods
Mouse hippocampal HT22 cells were pre-treated with propofol, followed by Ang II treatment. The expression of synaptic proteins (synapsin I and PSD95) was examined. The effects of propofol on Ang II-induced NADPH oxidase expression and superoxide anion generation were examined. The effects of propofol on intracellular calcium concentration, the activation of calcium/calmodulin-dependent protein kinase II (CaMKII), and protein kinase C (PKC) were measured.
Results
Ang II reduced the expression of synapsin I and PSD95, which was attenuated by propofol. Ang II-induced effects were blocked by Ang II type 1 receptor (AT1 receptor) blocker. Ang II induced the expression of NADPH oxidase and caused superoxide anion accumulation, which were attenuated by propofol. In addition, propofol induced intracellular calcium concentration, and activated CaMKII as well as PKCβ. Importantly, the Ang II-mediated effects were diminished by α-tocopherol, and the propofol-mediated effects were alleviated by calcium chelator, CaMKII inhibitor, and PKCβ inhibitor.
Conclusion
Ang II, via AT1 receptor, induced oxidative stress and reduced the expression of synapsin I and PSD95 in HT22 cells. Propofol may increase synapsin I and PSD95 expression by inhibiting oxidative stress and stimulating calcium signaling pathway.
https://ift.tt/2Nohi6x
Three dimensional evaluation of soft tissue after orthognathic surgery
To evaluate the nasolabial soft tissue change three-dimensionally after orthognathic surgery, using a structured light scanner.
https://ift.tt/2Pg3KMk
Hailey‐Hailey disease successfully treated with vitamin D oral supplementation
Dermatologic Therapy, Volume 0, Issue ja, -Not available-.
https://ift.tt/2NtBLHr
Nilotinib induction of melanogenesis via reactive oxygen species‐dependent JNK activation in B16F0 mouse melanoma cells
Experimental Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2pESu0H
Brimonidine displays anti‐inflammatory properties in the skin through the modulation of the vascular barrier function
Experimental Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2PgTJhI
Role of Noxa in proliferation, apoptosis and autophagy in human adenoid cystic carcinoma
Journal of Oral Pathology &Medicine, Volume 0, Issue ja, -Not available-.
https://ift.tt/2y1RKaE
Recent developments and highlights in biomarkers in allergic diseases and asthma
Allergy, Volume 0, Issue ja, -Not available-.
https://ift.tt/2zVlSFW
Long‐term efficacy of novel therapies in moderate‐to‐severe plaque psoriasis: a systematic review and network meta‐analysis of PASI response
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2y5049B
Position Statement – Linear Prurigo is a Subtype of Chronic Prurigo
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2NrTL4S
Insuline resistance, mTOR and Hidradenitis suppurativa
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2y501dV
Acute localised exanthematous pustulosis due to metronidazole
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2Ns3UhI
mTORC1 at the crossroad of metabolism and immunity in hidradenitis suppurativa
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2y6sksk
The value of dermoscopy in diagnosing eyebrow loss in patients alopecia areata and frontal fibrosing alopecia
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2NreBkW
Clinical evaluation of a low-shrinkage resin composite in endodontically treated premolars: 3-year follow-up
Abstract
Objectives
This study compared the 3-year clinical performance of a low-shrinkage silorane-based composite material with that of a methacrylate-based composite material in the restoration of endodontically treated premolar teeth.
Materials and methods
A total of 70 patients requiring a Class II composite-resin restoration of a premolar tooth following root-canal treatment participated in the study. Cavities were restored with either a silorane-based restorative (Filtek Silorane + Silorane System Adhesive) or a methacrylate-based restorative (Filtek Z250 + Clearfil SE Bond) system applied according to the manufacturer's instructions. Restorations were evaluated by two blinded observers at five different time intervals (baseline; 6 months; 1, 2, and 3 years) according to modified USPHS criteria. Pearson's chi-square tests were used to examine differences in the clinical performance of the materials (retention, color match, marginal discoloration, secondary caries, anatomical form, marginal adaptation, and surface roughness), and Friedman and Wilcoxon tests were used to compare changes between baseline and each recall time, with a level of 0.05 considered statistically significant.
Results
After 3 years, no statistically significant differences in clinical performance were observed between the two materials (p > 0.05). Intra-system comparisons revealed a statistically significant deterioration in color match, marginal discoloration, anatomical form, marginal adaptation, and surface roughness scores after 3 years for both systems. Although the difference was not significant at 3 years of follow-up, the level of deterioration in marginal adaptation and surface roughness was greater for the Filtek Silorane restoration than for the Filtek Z250 restoration at the 1 year follow-up (p > 0.05).
Conclusion
Restorations of both materials were clinically acceptable after 3 years. The Filtek Silorane system did not appear to offer any clinical advantages over the methacrylate-based system when used in the restoration of Class II cavities in endodontically treated premolars.
Clinical relevance
The restoration of endodontically treated premolars with minor or moderate loss of tooth structure can be directly performed either with silorane or methacrylate-based composite resins.
https://ift.tt/2BZuFYP
International neural monitoring study group guideline 2018 part I: Staging bilateral thyroid surgery with monitoring loss of signal
The Laryngoscope, EarlyView.
https://ift.tt/2pDTHFv
Kids Nowadays Hear Better Than We Did: Declining Prevalence of Hearing Loss in US Youth, 1966–2010
The Laryngoscope, EarlyView.
https://ift.tt/2zUQbwm
Impact of face proportions on face attractiveness
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2OcU5tx
Clinical evaluation of the lightening effect of cytidine on hyperpigmented skin
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2E2tMS6
Use of a novel 589‐nm solid‐state laser for treatment of facial erythema
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2OdyBMX
Serum amyloid A levels in the blood of patients with atopic dermatitis and cutaneous T‐cell lymphoma
The Journal of Dermatology, EarlyView.
https://ift.tt/2y4atm2
Prediction of therapeutic response before and during i.v. cyclophosphamide pulse therapy for interstitial lung disease in systemic sclerosis: A longitudinal observational study
The Journal of Dermatology, EarlyView.
https://ift.tt/2NrhQbL
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