ROC curve of the Pediatric Voice Related Quality-of-Life Survey (P-VRQOL)
ROC curve of the Pediatric Voice Related Quality-of-Life Survey (P-VRQOL): RESUMO Verificar a eficiência e determinar a nota de corte do instrumento Qualidade de Vida em Voz Pediátrico (QVV-P), bem como as medidas de sensibilidade, especificidade e eficiência. Participaram 230 voluntários, pais/responsáveis de crianças/adolescentes com e sem queixa vocal, de ambos os gêneros, com idade entre 2 e 18 anos, que responderam a versão brasileira validada do QVV-P, cujos três escores (geral, físico e socioemocional) foram analisados pela Receiver Operating Characteristic Curve (curva ROC).... περισσότερα »
Phonological awareness intervention and attention efficiency in children at risk
evidence of effectiveness on visual attention: ABSTRACT Using a pretest and posttest comparison group design, this 20 weeks study investigated the effects of a phonological awareness training program (PATP) on attention efficiency (AE) in 57 children (age = 5 to 6 years) at risk. The experimental group received the PATP (EG; n=30). We obtained pretest and posttest measures of phonological awareness and AE. The ANOVA showed significant interaction effects of the PATP and time on phonological awareness and AE. For both groups, posttest AE score means were higher than pretest score mea... περισσότερα »
Children’s language development after cochlear implantation: a literature review
Children’s language development after cochlear implantation: a literature review: RESUMO Objetivo Levantar na literatura a descrição do desenvolvimento de linguagem de crianças usuárias de implante coclear. Estratégias de pesquisa Buscas na plataforma Pubmed e nas bases de dados Web of Science, Scopus e Science Direct, seguindo etapas de seleção e análise crítica dos periódicos encontrados e escolhidos. Critérios de seleção Selecionados artigos originais que abordavam crianças usuárias de implante coclear, nos quais eram mencionados o desenvolvimento de linguagem após a cirurgia. Ex... περισσότερα »
Aesthetic and functional outcomes in rhinoplasty surgery
Evaluation of : a prospective study via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Author(s): Sara Sena Esteves, Miguel Gonçalves Ferreira, João Carvalho Almeida, José Abrunhosa, Cecília Almeida e Sousa IntroductionEvaluation of surgery outcome measured by patient satisfaction or quality of life is very important, especially in plastic surgery. There is increasing interest in self-reporting outcomes evaluation in plastic surgery.ObjectiveThe aim of our study was to determine patient satisfaction in regard to nose appearance and function with the use of a valid... περισσότερα »
Comparison of 2 Zero-Profile Implants in the Treatment of Single-Level Cervical Spondylotic Myelopathy: A Preliminary Clinical Study of Cervical Disc Arthroplasty versus Fusion
Comparison of 2 Zero-Profile Implants in the Treatment of Single-Level Cervical Spondylotic Myelopathy: A Preliminary Clinical Study of Cervical Disc Arthroplasty versus Fusion: by Sheng Shi, Shuang Zheng, Xin-Feng Li, Li-Li Yang, Zu-De Liu, Wen Yuan Objectives Cervical disc arthroplasty (CDA) with Discover prosthesis or anterior cervical discectomy and fusion (ACDF) with Zero-P cage has been widely used in the treatment of cervical spondylotic myelopathy (CSM). However, little is known about the comparison of the 2 zero-profile implants in the treatment of single-level CSM. The ... περισσότερα »
In crooked nose: middle turbinate pneumatization
An often neglected area via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Author(s): Fatih Özdoğan, Halil Erdem Özel, Erkan Esen, Erdem Altıparmak, Selahattin Genç, Adin Selçuk IntroductionCrooked or deviated nose is a deviation of the nose from the straight vertical position of the face. Extensive pneumatization of the middle turbinate, also called concha bullosa or bullous middle turbinate (BMT) is known to be one of the possible etiologic factors in nasal obstruction, recurrent sinusitis, and headache. There is no study concerning a link between BMT and cr... περισσότερα »
Melatonin and vitamin C treatment on the experimentally induced tympanosclerosis
The effect of : study in rats via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Author(s): Sema Koc, Halil Kıyıcı, Aysun Toker, Harun Soyalıç, Huseyin Aslan, Hakan Kesici, Zafer I. Karaca IntroductionThe ethiopathogenesis of tympanosclerosis (TS) has not been completely understood yet. Recent studies have shown that free oxygen radicals are important in the formation of TS. Melatonin and Vitamin C are known to be a powerful antioxidant, interacts directly with Reactive Oxygen Species (ROS) and controls free radical-mediated tissue damage.ObjectiveTo demonstrate... περισσότερα »
Intranasal corticosteroids in adult patients
Medical adherence to via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Author(s): Emre Ocak, Baran Acar, Deniz Kocaöz IntroductionThe adherence to medical treatment in allergic rhinitis (AR) is poorly evaluated in clinical practice.ObjectivesTo evaluate adherence to intranasal corticosteroids (ICS) in the treatment of allergic rhinitis AR patients.MethodsThis prospective study was conducted on adult patients who were admitted to the outpatient clinic of the otolaryngology department tertiary hospital. Patients diagnosed with moderate to severe persistent AR an... περισσότερα »
Thromboangiitis Obliterans
The Incidence and Prevalence of Thromboangiitis Obliterans in Taiwan: A Nationwide, Population-based Analysis of Data Collected from 2002 to 2011: OBJECTIVE: To estimate the incidence and prevalence of thromboangiitis obliterans in Taiwan in the period spanning from 2002 to 2011. METHODS: We identified all incident and prevalent cases with a diagnosis of thromboangiitis obliterans (International Classification of Diseases, Ninth Revision code 443.1) in the period spanning from 2002 to 2011 using Taiwan’s National Health Insurance Research Database. We calculated the age- and sex-spe... περισσότερα »
Accuracy of magnetic resonance imaging for measuring maturing cartilage: A phantom study
Accuracy of magnetic resonance imaging for measuring maturing cartilage: A phantom study: OBJECTIVES: To evaluate the accuracy of magnetic resonance imaging measurements of cartilage tissue-mimicking phantoms and to determine a combination of magnetic resonance imaging parameters to optimize accuracy while minimizing scan time. METHOD: Edge dimensions from 4 rectangular agar phantoms ranging from 10.5 to 14.5 mm in length and 1.25 to 5.5 mm in width were independently measured by two readers using a steel ruler. Coronal T1 spin echo (T1 SE), fast spoiled gradient-recalled echo (FSPG... περισσότερα »
Impact of radiotherapy on implant-based prosthetic rehabilitation in patients with head and neck cancer: A prospective observational study on implant survival and quality of life─Preliminary results
Impact of radiotherapy on implant-based prosthetic rehabilitation in patients with head and neck cancer: A prospective observational study on implant survival and quality of life─Preliminary results: SummaryPurpose To study implant-based prosthetic rehabilitation of head and neck cancer patients with focus on implant survival and quality of life. Materials and Methods The prospective observational study presents preliminary results of 29 edentulous head neck cancer patients (20 patients after radiotherapy) with 165 OsseoSpeed implants. Implant success after 1-year follow-up was ... περισσότερα »
Severe Compromise of Preosteoblasts in a Surgical Mouse Model of Bisphosphonate-Associated Osteonecrosis of the Jaw
Severe Compromise of Preosteoblasts in a Surgical Mouse Model of Bisphosphonate-Associated Osteonecrosis of the Jaw: AbstractObjectives The effect of amino-bisphosphonates on osteoblastic lineage and its potential contribution to the pathogenesis of bisphosphonate-associated osteonecrosis of the jaw (BONJ) remain controversial. We assessed the effects of zoledronic acid (ZOL) on bone and vascular cells of the alveolar socket using a mouse model of BONJ. Material and Methods Thirty-two mice were treated twice a week with either 100 μg/kg of ZOL or saline for 12 weeks. The first ... περισσότερα »
ENPP1 and ESR1 genotypes influence temporomandibular disorders development and surgical-treatment response in dento-facial deformities
ENPP1 and ESR1 genotypes influence temporomandibular disorders development and surgical-treatment response in dento-facial deformities: Abstract Dentofacial deformities are dys-morpho-functional disorders involving the temporomandibular joints (TMJ). Many authors have report a TMJ improvement in dysfunctional subjects with malocclusion after orthodontic or combined orthodontic and surgical treatment particularly for the relief of pain. In particular, few studies have highlighted the demographic and clinical predictors of response to surgical treatment. To date, no genetic facto... περισσότερα »
A prospective multicenter study to compare the precision of posttraumatic internal orbital reconstruction with standard preformed and individualized orbital implants
A prospective multicenter study to compare the precision of posttraumatic internal orbital reconstruction with standard preformed and individualized orbital implants: A variety of implants are available for orbital reconstruction. Titanium orbital mesh plates are available either as standard preformed implants or able to be individualized for the patient. The aim of this study was to analyze whether individualized orbital implants allow a more precise reconstruction of the orbit than standard preformed implants. SummaryPurpose A variety of implants are available for orbital rec... περισσότερα »
Laminin-5 and insulin-like growth factor−II mRNA binding protein−3 (IMP3) expression in preoperative biopsy specimens from oral cancer patients: Their role in neural spread risk and survival stratification
Laminin-5 and insulin-like growth factor−II mRNA binding protein−3 (IMP3) expression in preoperative biopsy specimens from oral cancer patients: Their role in neural spread risk and survival stratification: Perineural invasion (PNI) hinders the ability to establish local control of oral squamous cell carcinoma (OSCC). To date, PNI can be evaluated only in surgical specimens and not in preoperative biopsy material, rendering timely therapeutic planning impossible. Insulin-like growth factor−II mRNA binding protein−3 (IMP3) expression appears to be of diagnostic and prognostic utility... περισσότερα »
Surgical reconstruction of maxillary defects using a computer-assisted design/computer-assisted manufacturing−produced titanium mesh supporting a free flap
Surgical reconstruction of maxillary defects using a computer-assisted design/computer-assisted manufacturing−produced titanium mesh supporting a free flap: The maxilla provides support to the overlying structures and contributes significantly to the overall facial appearance and to critical functions such as mastication, speech, and deglutition. Many different techniques have been used over the years to achieve this reconstructive goal. Modern computer-assisted surgery affords new methods for planning resections, as well as optimising reconstructive outcomes and functional rehabili... περισσότερα »
De-epithelialised radial forearm free flap to recontour the buccal commissure
De-epithelialised radial forearm free flap to recontour the buccal commissure: The radial forearm flap or “Chinese flap” has been used commonly since its development in 1978 by Yang et al.1 Modifications over the years have included suprafascial flaps, musculocutaneous and tendinocutaneous flaps, composite flaps with vascularised bone from the radius, the reverse forearm flap, and others.2 The features that make it so versatile (it is both pliable and manoeuvrable) often mean that it can fold on itself at the commissure, which results in a poor aesthetic appearance and threatens com... περισσότερα »
Tuberosity-alveolar block as a donor site for localised augmentation of the maxilla: a retrospective clinical study
Tuberosity-alveolar block as a donor site for localised augmentation of the maxilla: a retrospective clinical study: Bone from the maxillary tuberosity has been harvested in particulate form to use for augmentation for several years, but block grafts have not been extensively used. A considerable advantage of a particulate bone graft from the maxillary tuberosity over those from other intraoral donor sites is the relative simplicity of harvesting and minimal complications.We have retrospectively assessed the efficacy of tuberosity-alveolar block bone (posterior maxillary alveolar ri... περισσότερα »
Dupilumab: Targeted Therapy for Chronic Rhinosinusitis With Polyps
Dupilumab: Targeted Therapy for Chronic Rhinosinusitis With Polyps: This commentary on an article recently published in JAMA discusses the use of subcutaneous dupilumab in adults with chronic rhinosinusitis with polyps. JAMA Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial Claus Bachert, MD, PhD; Leda Mannent, MD; Robert M. Naclerio, MD; et al. *Importance* Dupilumab has demonstrated efficacy in patients with asthma and atopic dermatitis, which are both type 2 helper T-cell–mediated diseases... περισσότερα »
New Recommendations for the Treatment of Differentiated Thyroid Cancer
New Recommendations for the Treatment of Differentiated Thyroid Cancer: [image: ovp160003.pdf.gif] This Viewpoint assesses the treatment options for differentiated thyroid cancer in patients at low risk for locoregional recurrence and disease-specific mortality.
Patient With Nasal Obstruction
Patient With Nasal Obstruction: [image: s_ocg160015f1.png] A woman had chronic bilateral nasal congestion without facial pressure, pain, paresthesia, bleeding, dysphagia, or voice change; endoscopy demonstrated moderate mucosal edema, and computed tomography revealed a nasopharyngeal mass that appeared hypodense. What is your diagnosis? [image: First page PDF preview]
Practice Patterns of Antireflux Medication for Chronic Rhinosinusitis
Practice Patterns of Antireflux Medication for Chronic Rhinosinusitis: This cross-sectional analysis uses data from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey to determine whether chronic rhinosinusitis is associated with administration of antireflux medications. Importance Antireflux medication has been endorsed as a useful adjunctive therapy for chronic rhinosinusitis, but its use remains controversial. Objectives To determine whether chronic rhinosinusitis is associated with administration of proton pump inhibitors, h... περισσότερα »
Education on, Exposure to, and Management of Vascular Anomalies
Education on, Exposure to, and Management of Vascular Anomalies: This survey study explores otolaryngology trainees’ education in, exposure to, and comfort level with vascular anomalies. Importance The field of vascular anomalies presents diverse challenges in diagnosis and management. Although many lesions involve the head and neck, training in vascular anomalies is not universally included in otolaryngology residencies and pediatric otolaryngology (POTO) fellowships. Objective To explore the education in, exposure to, and comfort level of otolaryngology trainees with vasc... περισσότερα »
Use of Hearing Devices and Depressive Symptoms in Older Adults
Use of Hearing Devices and Depressive Symptoms in Older Adults: This observational study investigates the association of treatment with a hearing aid or cochlear implant with depressive symptoms in older adults. Importance Hearing loss is a common health problem in older adults that is strongly associated with the development of depression. Previous cross-sectional studies have reported lower odds of depression among individuals who use hearing aids. However, there have been limited prospective studies investigating the effect of hearing loss treatments on depressive symptoms.... περισσότερα »
Reflux and Chronic Rhinosinusitis
Reflux and Chronic Rhinosinusitis: [image: oic160006.pdf.gif] No disease has been implicated more frequently as a comorbid cause of upper airway diseases than gastroesophageal reflux disease. Supraesophageal reflux of stomach acid has been suggested to lead to a large number of otolaryngologic conditions, including such disparate morbidities as dysphonia, laryngospasm, vocal cord dysfunction, globus sensation, vocal process granulomas, throat pain, laryngeal cancer, chronic otitis media, rhinitis, asthma, and chronic rhinosinusitis (CRS). Our understanding of the subtleties of ... περισσότερα »
Eosinophilic esophagitis (EoE)
Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models: - Anne C. A. Mudde, - Willem S. Lexmond, - Richard S. Blumberg, - Samuel Nurko and - Edda FiebigerEmail authorView ORCID ID profile World Allergy Organization Journal2016*9*:23 *DOI: *10.1186/s40413-016-0114-3 © Mudde et al. 2016 *Published: *15 July 2016 Abstract Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus and commonly classified as a Th2-type a... περισσότερα »
HNSCC : p38 MAPK mediates epithelial-mesenchymal transition by regulating p38IP and Snail
p38 MAPK mediates epithelial-mesenchymal transition by regulating p38IP and Snail in head and neck squamous cell carcinoma via ScienceDirect Publication: Oral Oncology Publication date: September 2016 *Source:*Oral Oncology, Volume 60 Author(s): Yuan Lin, Jon Mallen-St. Clair, Guanyu Wang, Jie Luo, Fernando Palma-Diaz, Chi Lai, David A. Elashoff, Sherven Sharma, Steven M. Dubinett, Maie St. John BackgroundIn the present study, we investigated the role of p38-p38IP signaling in the inflammation-induced promotion of epithelial-to-mesenchymal transition (EMT) in Head and Neck Squamous Ce... περισσότερα »
Diffusion MRI: Literature review in salivary gland tumors
Diffusion MRI: Literature review in salivary gland tumors: [image: cover.gif?v=1&s=6b7fabf9f2cf854f1cd69ce8] Abstract Surgical resection is currently the best treatment for salivary gland tumors. A reliable magnetic resonance imaging mapping, encompassing tumor grade, location and extension, may assist safe and effective tumor resection and provide better information for patients regarding potential risks and morbidity after surgical intervention. However, direct examination of the tumor grade and extension using conventional morphological MRI remains difficult, often requiring ... περισσότερα »
Immune responses to casein in children with FPIES caused by cow’s milk (CM)
Humoral and cellular responses to casein in food protein-induced enterocolitis to cow’s milk via Allergy and Clinical Immunology Publication date: Available online 15 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Jean Christoph Caubet, Ramon Bencharitiwong, Andrew Ross, Hugh A. Sampson, M. Cecilia Berin, Anna Nowak-Węgrzyn BackgroundFood protein-induced enterocolitis syndrome (FPIES) is a non-IgE mediated food allergy manifesting within 1-4 hours of food ingestion with repetitive emesis and lethargy.ObjectiveTo characterize immune responses to casein in chil... περισσότερα »
Mutations in LAT can lead to SCID and highlight the critical role of LAT in TCR signalling in T cell development
Mutations in LAT lead to a novel form of severe combined immunodeficiency via Allergy and Clinical Immunology Publication date: Available online 15 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Chiara Bacchelli, Federico A. Moretti, Marlene Carmo, Stuart Adams, Horia C. Stanescu, Kerra Pearce, Manisha Madkaikar, Kimberly C. Gilmour, Adeline K. Nicholas, C. Geoffrey Woods, Robert Kleta, Phil L. Beales, Waseem Qasim, H. Bobby Gaspar BackgroundSignalling through the T cell receptor (TCR) is critical for T cell development and function. Linker for activation of ... περισσότερα »
Single amino acid resolution mapping of linear peanut allergen epitopes using high density peptide arrays demonstrates patient specific and highly persistent antibody binding patterns.
Linear epitope mapping of peanut allergens demonstrates individualized and persistent antibody binding patterns via Allergy and Clinical Immunology Publication date: Available online 15 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Christian S. Hansen, Martin Dufva, Katrine L. Bøgh, Eric Sullivan, Jigar Patel, Thomas Eiwegger, Zsolt Szépfalusi, Morten Nielsen, Anders Christiansen Here, high-density peptide arrays were applied to map linear IgE and IgG4 epitopes at the single amino acid level in patients. IgE and IgG4 binding patterns were heterogeneous betw... περισσότερα »
Sublingual Immunotherapy Tablets and Pharmacotherapies for Seasonal and Perennial Allergic Rhinitis
Treatment Effect of Sublingual Immunotherapy Tablets and Pharmacotherapies for Seasonal and Perennial Allergic Rhinitis: Pooled Analyses via Allergy and Clinical Immunology Publication date: Available online 15 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Stephen R. Durham, Peter. S. Creticos, Harold. S. Nelson, Ziliang Li, Amarjot Kaur, Eli. O. Meltzer, Hendrik Nolte BackgroundData comparing the treatment effect of allergy immunotherapy and pharmacotherapy are lacking.ObjectiveIndirectly compare the treatment effect of sublingual immunotherapy (SLIT) tablet... περισσότερα »
Specific IgE reactivity to ns-LTPs is prevalent in patients with pollen and/or plant food allergic symptoms
IgE-reactivity profiles to non-specific Lipid Transfer Proteins (ns-LTP) in a north-western European country via Allergy and Clinical Immunology Publication date: Available online 15 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Margaretha A. Faber, Athina L. Van Gasse, Ine I. Decuyper, Astrid Uyttebroek, Vito Sabato, Margo M. Hagendorens, Chris H. Bridts, Luc S. De Clerck, Montserrat Fernandez-Rivas, Mariona Pascal, Araceli Diaz-Perales, Didier G. Ebo TeaserSpecific IgE reactivity to ns-LTPs is prevalent in patients with pollen and/or plant food allergic ... περισσότερα »
Alarmins & Food allergy
“The False Alarm” hypothesis: Food allergy is associated with high dietary advanced glycation end products and pro-glycating dietary sugars that mimic alarmins via Allergy and Clinical Immunology Publication date: Available online 15 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Peter K. Smith, Madhan Masilamani, Xiu-Min Li, Hugh A. Sampson The incidence of food allergy has risen dramatically in the last few decades in Westernized developed countries. We propose that the Western life style and diet promote innate danger signals and immune responses through ... περισσότερα »
The allergy-protective effects of the cowshed bacterium, Lactococcus lactis G121
Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects via Allergy and Clinical Immunology Publication date: Available online 15 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Karina Stein, Stephanie Brand, André Jenckel, Anna Sigmund, Zhijian James Chen, Carsten J. Kirschning, Marion Kauth, Holger Heine BackgroundBacterial cowshed isolates are allergy-protective in mice; however, the underlying mechanisms are largely unknown. Here, we examined the ability of Lactococcus lactis G121 to prevent ... περισσότερα »
IL-22 induction by mechanical injury limits cutaneous infection of Staphylococcus aureus
IL-22 derived from γδ T cells restricts Staphylococcus aureus infection of mechanically injured skin via Allergy and Clinical Immunology Publication date: Available online 15 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Nidhi Malhotra, Juhan Yoon, Juan Manuel Leyva-Castillo, Claire Galand, Nathan Archer, Lloyd S. Miller, Raif S. Geha BackgroundS. aureus is an opportunistic pathogen that colonizes the skin of patients with atopic dermatitis (AD) and aggravates their disease. Neutrophils and the cytokines IL-17A and IL-17F, which drive the expression of the ... περισσότερα »
Omalizumab in patients with atopic dermatitis
Efficacy of omalizumab in patients with atopic dermatitis: a systematic review and meta-analysis via Allergy and Clinical Immunology [image: alertIcon.gif] Publication date: Available online 14 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Hsiao-Han Wang, Yu-Chuan Li, Yu-Chen Huang TeaserFrom this meta-analysis and systematic review, 43% of the atopic dermatitis patients could achieve excellent clinical response after omalizumab treatment and the potential therapeutic benefits might be seen in selected patients with lower IgE levels.
Particulate pollution and extreme temperatures can influence nasopharyngeal bacterial carriage and predispose to invasive infection. Climatic factors likely influence bacterial disease incidence in areas of high temperature and dusty winds such as the African meningitis belt.
Airborne dust and high temperatures are risk factors for invasive bacterial disease via Allergy and Clinical Immunology Publication date: Available online 14 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Jean-Francois Jusot, Daniel R. Neill, Elaine M. Waters, Mathieu Bangert, Marisol Collins, Laura Bricio Moreno, Katiellou Lawan Lawan, Mouhaiminou Moussa Moussa, Emma Dearing, Dean Everett, Jean-Marc Collard, Aras Kadioglu BackgroundThe Sahel region of West Africa has the highest bacterial meningitis attack and case fatality rate in the world. The impact of ... περισσότερα »
Treponema denticola is strongly associated with the development of periodontal disease
Characterization of a potential ABC-type bacteriocin exporter protein from Treponema denticola: Abstract Background*Treponema denticola* is strongly associated with the development of periodontal disease. Both synergistic and antagonistic effects are observed among bacterial species in the process of biofilm formation. Bacteriocin-related genes have not yet been fully characterized in periodontopathic bacteria. The aim of this study was to detect and characterize bacteriocin-associated proteins in *T. denticola.* MethodsThe whole genome sequence of *T. denticola* ATCC 35405 w... περισσότερα »
Perineural Invasion of Oral Squamous Cell Carcinoma: A New Hurdle for Surgeons
Perineural Invasion of Oral Squamous Cell Carcinoma: A New Hurdle for Surgeons: AbstractThe high rate of mortality associated with cancer is due to its inherent nature to metastasize. Perineural invasion (PNI) is a relatively rare mode of metastasis, and a distinct pathologic entity that can be observed in the absence of lymphatic or vascular invasion which is still shrouded by mystery. PNI is a marker of poor prognosis. Despite increasing recognition of this metastatic process, there has been little progress in the understanding of mechanisms behind PNI. The purpose of this articl... περισσότερα »
The Carbonic Anhydrases from Streptococcus mutans and Porphyromonas gingivalis
An Overview of the Carbonic Anhydrases from Two Pathogens of the Oral Cavity: Streptococcus mutans and Porphyromonas gingivalis: Among the crowd of bacteria provoking disease of the oral cavity during the weakened of immune system, Streptococcus mutans and Porphyromonas gingivalis are the main microorganisms implicated in caries formation and periodontitis, respectively. The life cycle of the pathogens, such as protozoa, fungi and bacteria, is influenced by a superfamily of enzymes, called carbonic anhydrases (CAs, EC 4.2.1.1). These metalloenzymes, being crucial for the survival of... περισσότερα »
Hepatotoxicity Induced by a Chinese Herbal Medicine Containing Sildenafil
A Case of Hepatotoxicity Induced by Adulterated “Tiger King”, a Chinese Herbal Medicine Containing Sildenafil: Detection of Phosphodiesterase Type 5 (PDE-5) inhibitors and their analogues in “100% natural” or “herbal” supplements have been described in numerous reports. However, few reports have been published in relation to actual harm caused by counterfeit erectile dysfunction herbal supplements. We describe a case of a 65-year old male admitted to a tertiary hospital with acute liver toxicity, possibly induced by adulterated “Chinese herbal” supplement “Tiger King” for sexual enh... περισσότερα »
Photobiomodulation: Implications for Anesthesia and Pain Relief
Photobiomodulation: Implications for Anesthesia and Pain Relief: Photomedicine and Laser Surgery , Vol. 0, No. 0. Author information Roberta T. Chow, MB, BS (Hons), FRACGP, PhD,1 and Patricia J. Armati, PhD2 1Honorary Research Associate, Brain & Mind Centre, The University of Sydney, Camperdown, New South Wales. 2Neuroinflammation Group, Brain & Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia. Address correspondence to: *Roberta Chow* *Honorary Research Associate* *Brain & Mind Centre* *The University of Sydney* *Level 7, M02F | 94 Mallett Street* *Cam... περισσότερα »
CO2 Laser Excision of a Pyogenic Granuloma
CO2 Laser Excision of a Pyogenic Granuloma Associated with Dental Implants: A Case Report and Review of the Literature: Photomedicine and Laser Surgery , Vol. 0, No. 0. Author information Astrid Truschnegg, MD, DDS,1 Stephan Acham, MD, DDS,1 Lumnije Kqiku, MD, DDS ,2 Alfred Beham, MD,3 andNorbert Jakse, MD, DDS1 1Department of Oral Surgery and Orthodontics, Medical University Graz, Graz, Austria. 2Department of Prosthodontics, Restorative Dentistry, Periodontology and Implantology, University Clinic of Dental Medicine and Oral Health, Medical University Graz, Graz, Austria. 3IMAH... περισσότερα »
Single Session of Low-Level Laser Therapy with a 940 nm Wavelength Diode Laser on Pain, Swelling, and Trismus
Effectiveness of Single Session of Low-Level Laser Therapy with a 940 nm Wavelength Diode Laser on Pain, Swelling, and Trismus After Impacted Third Molar Surgery: Photomedicine and Laser Surgery , Vol. 0, No. 0. Author information Cennet Neslihan Eroglu, DDS, PhD, and Serap Keskin Tunc, DDS, PhD Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yuzuncu Yil University, Van, Turkey. Address correspondence to: *Cennet Neslihan Eroglu* *Yuzuncu Yil University* *Faculty of Dentistry* *Department of Oral and Maxillofacial Surgery* *Campus 65080* *Van/Turkey* *E-mail:* n... περισσότερα »
Atlantoaxial Proactive Vertebral Artery Injury Prevention
Biomechanical Study of 3 Atlantoaxial Proactive Vertebral Artery Injury Prevention Fixation Combinations via World Neurosurgery [image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Peng Zhang, Qi Liu, Tianming Xu, Dezhi Sun, Jun Yang, Bin Ni ObjectiveTo evaluate the biomechanical stability of 3 atlantoaxial proactive vertebral artery injury prevention fixation combinations.MethodsWe used 6 fresh human cadaveric C0-C4 specimens for the biomechanical test with moment control in 6 loading directions. First, range of motion (ROM) was ... περισσότερα »
Axis Body Fracture
Direct C2 Pedicle Screw Fixation for via World Neurosurgery [image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Jennifer A. Reynolds, Joel D. MacDonald BackgroundAcute complex C2 vertebral body fracture specifically does not involve the odontoid process or C2 pars interarticularis. External stabilization can be effective but may prolong healing and increase morbidity. Many traditional surgical techniques can achieve internal stabilization at the expense of normal cervical motion. We describe direct surgical C2 pedicle screw fixa... περισσότερα »
Track-Density Imaging of the Human Brainstem for Anatomic Localization of Fiber Tracts and Nerve Nuclei
in Vivo: Initial Experience with 3-T Magnetic Resonance Imaging via World Neurosurgery [image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Holger Wenz, Mansour Al-Zghloul, Eva Hart, Stefan Kurth, Christoph Groden, Alex Förster BackgroundThe brainstem comprises a large variety of fiber tracts and nerve nuclei and is unarguably one of the most crucial parts of the brain. Reliable noninvasive visualization of its anatomy may help relate normal and pathological anatomic variations to neurologic/psychiatric disorders. In this study,... περισσότερα »
Predictors of Stroke and Coma After Neurosurgery
: An ACS-NSQIP Analysis via World Neurosurgery [image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Alexandra M.G. Larsen, David J. Cote, Aditya V. Karhade, Timothy R. Smith ObjectiveThe American College of Surgeons National Surgical Quality Improvement Program database aims to reduce 30-day postoperative complications. Reduction of postoperative stroke and coma can decrease length and cost of hospitalization, improve patient functional status, and decrease morbidity and mortality.MethodsWe performed a search of the American Coll... περισσότερα »
Angioedema in the omalizumab chronic idiopathic/spontaneous urticaria
pivotal studies via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology *Source:*Annals of Allergy, Asthma & Immunology Author(s): James L. Zazzali, Allen Kaplan, Marcus Maurer, Karina Raimundo, Benjamin Trzaskoma, Paul G. Solari, Evgeniya Antonova, Meryl Mendelson, Karin E. Rosén BackgroundAngioedema, present in some patients with chronic idiopathic/spontaneous urticaria (CIU/CSU), may have a negative effect on patient quality of life.ObjectiveTo describe patient-reported angioedema and its management in the pivotal omalizumab studies (ASTERIA I, ASTERIA II, GLACIAL)... περισσότερα »
Theoretical Principles to Guide the Teaching of Adjectives to Children Who Struggle With Word Learning: Synthesis of Experimental and Naturalistic Research With Principles of Learning Theory
Theoretical Principles to Guide the Teaching of Adjectives to Children Who Struggle With Word Learning: Synthesis of Experimental and Naturalistic Research With Principles of Learning Theory: Purpose The purpose of this tutorial is to provide clinicians with a theoretically motivated and evidence-based approach to teaching adjectives to children who struggle with word learning. Method Given that there are almost no treatment studies to guide this topic, we have synthesized findings from experimental and theoretical literature to come up with a principles-based approach to treatmen... περισσότερα »
Evidence That Bimanual Motor Timing Performance Is Not a Significant Factor in Developmental Stuttering
Evidence That Bimanual Motor Timing Performance Is Not a Significant Factor in Developmental Stuttering: Purpose Stuttering involves a breakdown in the speech motor system. We address whether stuttering in its early stage is specific to the speech motor system or whether its impact is observable across motor systems. Method As an extension of Olander, Smith, and Zelaznik (2010), we measured bimanual motor timing performance in 115 children: 70 children who stutter (CWS) and 45 children who do not stutter (CWNS). The children repeated the clapping task yearly for up to 5 years. We ... περισσότερα »
New Technique for Mandibular Symphyseal Distraction by a Double-Level Anchorage and Fixation System: Advantages and Results.
New Technique for Mandibular Symphyseal Distraction by a Double-Level Anchorage and Fixation System: Advantages and Results.: Introduction: A surgical technique to widen the mandible is the mandibular midline distraction: the most common indications for mandibular midline distraction are severe mandibular anterior crowding, severe mandibular transverse deficiency, uni- or bilateral crossbite, impacted anterior teeth with inadequate space, and tipped teeth. Commonly used distraction devices can be divided into 2 systems: bone-borne distraction system appliance, dental-borne distracti... περισσότερα »
The Effects of Molding Helmet Therapy on Spring-Mediated Cranial Vault Remodeling for Sagittal Craniosynostosis.
The Effects of Molding Helmet Therapy on Spring-Mediated Cranial Vault Remodeling for Sagittal Craniosynostosis.: There is no clear consensus for the optimal treatment of sagittal craniosynostosis; however, recent studies suggest that improved neurocognitive outcomes may be obtained when surgical intervention imparts active cranial expansion or remodeling and is performed before 6 months of age. The authors consider spring-mediated cranioplasty (SMC) to optimally address these imperatives, and this is an investigation of how helmet orthoses before or after SMC affect aesthetic outco... περισσότερα »
Analysis of Lipoasiprated Following Centrifugation: Wet Versus Dry Harvesting Technique.
Analysis of Lipoasiprated Following Centrifugation: Wet Versus Dry Harvesting Technique.: Background: The success of lipotransfer strongly depends on the harvesting, processing, and placement of the lipoaspirated samples. This study was designed to assess the histomorphometric characteristics and viability of fat harvested using different techniques (wet and dry) following centrifugation, as described by Coleman. Methods: The study enrolled 85 consecutive, nonrandomized, healthy patients from March 2010 to December 2014 (45 males and 40 females). The mean age was 40 years (range, 18... περισσότερα »
Preoperative Use of Radiopaque Materials on Fractured Zygomatic Arch.
Preoperative Use of Radiopaque Materials on Fractured Zygomatic Arch.: Fractures of the zygoma are relatively frequent and their management has been extensively described. Above all, isolated zygomatic arch fractures comprise about 10% of all zygomatic fractures. Temporal approach is common surgical method, Gillies approach, but it has the limitation of blinded surgical approach. So, the mobile intraoperative fluoroscan is used famously for more suitable reduction, but it needs an additional man to control the machine and increases irradiation doses. The authors got the simple idea,... περισσότερα »
Osteocutaneous Second-Toe Free Flap as Alternative Option for Repair of Anterior Oronasal Fistula: Long-Term Results in Selected Patients.
Osteocutaneous Second-Toe Free Flap as Alternative Option for Repair of Anterior Oronasal Fistula: Long-Term Results in Selected Patients.: Introduction: Palatal fistulas anterior to the incisive foramen, generally seen as a complication of cleft lip and cleft palate repair, can be extremely difficult to repair. The requirements of the defect necessitate nasal lining, oral lining, and bone for maxillary arch continuity. Local pedicled flap has limited use in such patients with extensive scarring from previous surgeries. The authors have recently described a technique involving osteo... περισσότερα »
Preventing Suture Extrusion and Recurrence in Mustarde and Furnas Otoplasties by Using Laterally Based Postauricular Dermal Flap, Long-Term Results.
Preventing Suture Extrusion and Recurrence in Mustarde and Furnas Otoplasties by Using Laterally Based Postauricular Dermal Flap, Long-Term Results.: Background: Prominent ear deformity (PD) is an unacceptable condition of pinna that affects 5% of the population and is associated with emotional stress, behavioral disturbances, and social restrictions in relationships. Conchal hypertrphy, inadequate formation of antihelical fold, earlobe placement ahead than it should be, or various combinations of these changes are main characteristics of PD. Many surgical techniques have been descr... περισσότερα »
An Unconventional Presentation of Branchio-Oculo-Facial Syndrome.
An Unconventional Presentation of Branchio-Oculo-Facial Syndrome.: Branchio-oculo-facial syndrome (BOFS) is a rare disorder characterized by branchial or pharyngeal arch malformations, ocular findings, and craniofacial anomalies. Activating mutations in the enhancer-binding protein 2 alpha, TFAP2A, gene is responsible for the autosomal-dominant inheritance of BOFS. While documented patients of BOFS report wide variability in phenotype expressivity, patients typically demonstrate cervical or infra-auricular anomalies, diverse ocular malformations including microphthalmia and coloboma... περισσότερα »
Trochlear Nerve Schwannoma With Repeated Intratumoral Hemorrhage.
Trochlear Nerve Schwannoma With Repeated Intratumoral Hemorrhage.: Trochlear nerve schwannoma is extremely rare, with only 35 pathologically confirmed patients being reported in the literature. Here, the authors report a patient of trochlear nerve schwannoma in the prepontine cistern manifesting as facial pain and double vision and presenting the image characteristics of repeated intratumoral hemorrhage, which has never been reported in the literature. Total tumor along with a portion of the trochlear nerve was removed by using a retrosigmoid approach. Facial pain disappeared after ... περισσότερα »
Design and Fabrication of Kidney Phantoms for Internal Radiation Dosimetry using 3D Printing Technology
Currently, the validation of multimodal quantitative imaging and absorbed dose measurement is impeded by the lack of suitable, commercially available anthropomorphic phantoms of variable sizes and shapes. To demonstrate the potential of 3D printing techniques for quantitative SPECT/CT imaging, a set of kidney dosimetry phantoms and their spherical counterparts was designed and manufactured with a fused deposition modeling 3D printer. Nuclide-dependent SPECT/CT calibration factors were determined to assess the accuracy of quantitative imaging for internal renal dosimetry. *Methods* ... περισσότερα »
Nuclear medicine in cancer theranostics: beyond the target
http://ift.tt/2a4Oikd
A Pre-Analytical Validation Study of Automated Bone Scan Index: Effect on Accuracy and Reproducibility due to the Procedural Variabilities in Bone Scan Image Acquisition.
*Rationale:* The effect of the procedural variability in image acquisition on the quantitative assessment of bone scan is unknown. Here, we have developed and performed pre-analytical studies to assess the impact of the variability in scanning speed and in vendor specific gamma-camera on reproducibility and accuracy of the automated bone scan index (BSI). *Methods:* Two separate pre-analytical studies were performed. Patient-Study: To evaluate the effect on BSI reproducibility, repeat bone scans were prospectively obtained from metastatic prostate cancer patients enrolled in three... περισσότερα »
The Use of Published Clinical Study Reports to Support the United States Food and Drug Administration Approval of Imaging Agents
Pharmaceutical companies typically perform prospective, multicenter phase 3 clinical studies to support approval of a new imaging agent by the US Food and Drug Administration (FDA). In uncommon situations, FDA has approved imaging agents based solely, or in large part, on the clinical study experience described in published reports, including reports of exploratory (i.e., phase 1 or 2) studies performed at a single clinical site. We performed a survey of published reports to assess the potential for the information to support FDA approval of a commonly cited investigational imagin... περισσότερα »
Tumor specific binding of radiolabeled PEGylated GIRLRG peptide; a novel agent for targeting cancers.
Cancer specific targeting sparing normal tissues would significantly enhance cancer therapy outcomes and reduce cancer-related mortality. One approach is to target receptors and/or molecules that are specifically expressed on cancer cells. Peptides as cancer-specific targeting agents offer advantages such as ease of synthesis, low antigenicity and enhanced diffusion into tissues. Glucose regulated protein 78 (GRP78) is an endoplasmic reticulum stress chaperone that regulates the unfolded protein response and is over expressed in various cancers. In this study we evaluated GIRLRG p... περισσότερα »
KI researcher awarded 8.5 million dollar grant for MS study
The researcher Fredrik Piehl at the Department of Clinical Neuroscience at Karolinska Institutet has been rewarded a grant of approximately 8,5 million US dollar, from The Patient-Centered Outcomes Research Institute, PCORI, USA. Together with others researchers at the Department of Clinical Neuroscience and in collaboration with other clinical researchers in Sweden and in California, USA, Piehl will be studying the long-term efficacy of different disease-modifying treatments, DMT, for multiple sklerosis, MS. — There are several existing drugs registered for treatment of MS, but st... περισσότερα »
Mulberry (Morus alba L.) Fruit Extract Containing Anthocyanins Improves Glycemic Control and Insulin Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic C57BL/Ksj-db/db Mice
Journal of Medicinal Food , Vol. 0, No. 0. http://ift.tt/29Zdyou
Beneficial Effects of Silymarin After the Discontinuation of CCl4-Induced Liver Fibrosis
Journal of Medicinal Food , Vol. 0, No. 0. http://ift.tt/2a4Lsfi
Distinguishing the associations between daily mortality and hospital admissions and nitrogen dioxide from those of particulate matter: a systematic review and meta-analysis
Objectives To quantitatively assess time-series studies of daily nitrogen dioxide (NO2) and mortality and hospital admissions which also controlled for particulate matter (PM) to determine whether or to what extent the NO2 associations are independent of PM. Design A systematic review and meta-analysis. Methods Time-series studies—published in peer-reviewed journals worldwide, up to May 2011—that reported both single-pollutant and two-pollutant model estimates for NO2 and PM were ascertained from bibliographic databases (PubMed, EMBASE and Web of Science) and reviews. Random-e... περισσότερα »
Multidisciplinary team decision-making in cancer and the absent patient: a qualitative study
Objective To critically examine the process of multidisciplinary team (MDT) decision-making with a particular focus on patient involvement. Design Ethnographic study using direct non-participant observation of 35 MDT meetings and 37 MDT clinics, informal interviews and formal, semistructured interviews with 20 patients and 9 MDT staff members. Setting Three head and neck cancer centres in the north of England. Participants Patients with a diagnosis of new or recurrent head and neck cancer and staff members who attend the head and neck cancer MDT. Results Individual members o... περισσότερα »
Insights into significance of combined inhibition of MEK and m-TOR signalling output in KRAS mutant non-small-cell lung cancer
*Insights into significance of combined inhibition of MEK and m-TOR signalling output in KRAS mutant non-small-cell lung cancer* British Journal of Cancer advance online publication, July 21 2016. doi:10.1038/bjc.2016.220 Authors: Sophie Broutin, Adam Stewart, Parames Thavasu, Angelo Paci, Jean-Michel Bidart & Udai Banerji http://ift.tt/2acKvAT
Comment on ‘an Association of Cancer Physicians’ strategy for improving services and outcomes for cancer patients’
*Comment on 'an Association of Cancer Physicians' strategy for improving services and outcomes for cancer patients'* British Journal of Cancer advance online publication, July 21 2016. doi:10.1038/bjc.2016.168 Authors: Peter Selby & Johnathan Joffe http://ift.tt/2afjxeJ
The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas
*The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas* British Journal of Cancer advance online publication, July 21 2016. doi:10.1038/bjc.2016.187 Authors: Daniel Nettersheim, Isabell Arndt, Rakesh Sharma, Stefanie Riesenberg, Sina Jostes, Simon Schneider, Michael Hölzel, Glen Kristiansen & amp; Hubert Schorle http://ift.tt/2acKIUC
PRAME as diagnostic marker and as regulator for cell fate decisions in germ cell cancers
*PRAME as diagnostic marker and as regulator for cell fate decisions in germ cell cancers* British Journal of Cancer advance online publication, July 21 2016. doi:10.1038/bjc.2016.217 Author: Nina Neuhaus http://ift.tt/2afjy2h
Superior therapeutic efficacy of nab-paclitaxel over cremophor-based paclitaxel in locally advanced and metastatic models of human pancreatic cancer
*Superior therapeutic efficacy of nab-paclitaxel over cremophor-based paclitaxel in locally advanced and metastatic models of human pancreatic cancer* British Journal of Cancer advance online publication, July 21 2016. doi:10.1038/bjc.2016.215 Authors: N V Rajeshkumar, Shinichi Yabuuchi, Shweta G Pai, Zeen Tong, Shihe Hou, Scott Bateman, Daniel W Pierce, Carla Heise, Daniel D Von Hoff, Anirban Maitra & Manuel Hidalgo http://ift.tt/2acKflj
Genetic progression of Barrett’s oesophagus to oesophageal adenocarcinoma
*Genetic progression of Barrett's oesophagus to oesophageal adenocarcinoma* British Journal of Cancer advance online publication, July 21 2016. doi:10.1038/bjc.2016.219 Authors: Eleanor M Gregson, Jan Bornschein & Rebecca C Fitzgerald http://ift.tt/2afjCih
Expression of miR-210 in relation to other measures of hypoxia and prediction of benefit from hypoxia modification in patients with bladder cancer
*Expression of miR-210 in relation to other measures of hypoxia and prediction of benefit from hypoxia modification in patients with bladder cancer* British Journal of Cancer advance online publication, July 21 2016. doi:10.1038/bjc.2016.218 Authors: J J Irlam-Jones, A Eustace, H Denley, A Choudhury, A L Harris, P J Hoskin & C M L West http://ift.tt/2acKjBo
Phonological Priming in Children with Hearing Loss: Effect of Speech Mode, Fidelity, and Lexical Status.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Phonological Priming in Children with Hearing Loss: Effect of Speech Mode, Fidelity, and Lexical Status.: Objectives: This research determined (1) how phonological priming of picture naming was affected by the mode (auditory-visual [AV] versus auditory), fidelity (intact versus nonintact auditory onsets), and lexical status (words versus nonwords) of speech stimuli in children with prelingual sensorineural […]
Hearing and Vestibular Function After Preoperative Intratympanic Gentamicin Therapy for Vestibular Schwanomma as Part of Vestibular Prehab.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Hearing and Vestibular Function After Preoperative Intratympanic Gentamicin Therapy for Vestibular Schwanomma as Part of Vestibular Prehab.: Abstract Objective: To evaluate auditory and vestibular function after presurgical treatment with gentamicin in schwannoma patients. Background: The vestibular PREHAB protocol aims at diminishing the remaining vestibular function before vestibular schwannoma surgery, to ensure less acute symptoms from […]
