Analysis of antigen specific T cells in diabetes – Lessons from pre-clinical studies and early clinical trials
Publication date: Available online 12 April 2016 Source:Journal of Autoimmunity Author(s): Balasubramanian Krishnamurthy, Claudia Selck, Jonathan Chee, Guarang Jhala, Thomas W.H. Kay Antigen-specific immune tolerance promises to provide safe and effective therapies to prevent type 1 diabetes (T1D). Antigen-specific therapy requires two components: well-defined, clinically relevant autoantigens; and safe approaches to inducing tolerance in T… Continue reading Analysis of antigen specific T cells in diabetes – Lessons from pre-clinical studies and early clinical trials
Immunmodulation – neuer Ansatz in der Therapie von Depressionen?
Inflammation & Depression Wissenschaftliche Befunde weisen zunehmend darauf hin, dass inflammatorische Mechanismen bei der Entwicklung von Depressionen eine Rolle spielen. Folgerichtig rücken immunmodulatorische Therapieansätze in den Fokus der Forschung. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1NwDGVf via IFTTT
Therapists, researchers in Lincoln make swallowing easier – Sioux City Journal
Therapists, researchers in Lincoln make swallowing easier Sioux City Journal Eleven years ago, he said between bites, he went through radiation treatment for larynx cancer. So he knew from experience, as his … «Swallowing is the single-most complex system in the human body,» said Angela Dietsch, who teaches the graduate-level … and more » from… Continue reading Therapists, researchers in Lincoln make swallowing easier – Sioux City Journal
Pregabalin in the treatment of red scrotum syndrome: a report of two cases
Abstract Red scrotum syndrome is a poorly understood, chronic dysesthetic erythema primarily involving the anterior scrotum. Previous reports have indicated that red scrotum syndrome is occasionally responsive to oral doxycycline and oral gabapentin. Otherwise, few therapies have proven successful in treating the disorder. We report two cases of red scrotum syndrome responding to oral pregabalin, an anticonvulsant medication commonly used for neuropathic pain. These two cases suggest pregabalin as an effective means for treating red scrotum syndrome and endorse a neuropathic etiolo...περισσότερα »
A case of Scalp Rosacea treated with low dose doxycycline and probiotic therapy and literature review on therapeutic options
Abstract Rosacea is a common chronic inflammatory disorder showing a wide range of clinical features such as telangiectasia, erythema, papules, and pustules primarily involving the central part of face (forehead, cheeks and nose) although extra facial manifestation have been described. We describe a case of rosacea with predominant scalp involvement successfully treated with a 8-week-course of doxycycline 40 mg once a day and probiotic therapy twice a day (Bifidobacterium breve BR03, Lactobacillus salivarius LS01 1 × 109 UFC/dose). from #Dermatology via alexandrossfakianakis on I... περισσότερα »
Effectiveness of azathioprine pulse therapy in prolonging remission of psoriasis
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/23RrsQk via IFTTT
The state of melanoma: challenges and opportunities
Summary The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas – diagnosis/early detection, prevention, tumor cell dormancy (including metastasis), and therapy (response and resistance). These discussions extended over the course of 2015 and culminated at the Society of Melanoma Research 2015 International Congress in November... περισσότερα »
Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond
Publication date: Available online 16 April 2016 *Source:*Free Radical Biology and Medicine Author(s): Baris Bingol, Morgan Sheng Mitochondrial quality control is central for maintaining a healthy population of mitochondria. Two Parkinson's Disease genes, mitochondrial kinase PINK1 and ubiquitin ligase Parkin, degrade damaged mitochondria though mitophagy. In this pathway, PINK1 senses mitochondrial damage and activates Parkin by phosphorylating Parkin and ubiquitin. Activated Parkin then builds ubiquitin chains on damaged mitochondria to tag them for degradation in lysosomes. USP30...περισσότερα »
Outcome of Community-Acquired Staphylococcus aureus Bacteraemia in Patients with Diabetes
A Historical Population-Based Cohort Study: by Jesper Smit, Reimar Wernich Thomsen, Henrik Carl Schønheyder, Henrik Nielsen, Trine Frøslev, Mette Søgaard Background Patients with diabetes (DM) experience increased risk of Staphylococcus aureus bacteraemia (SAB), but the prognostic impact of diabetes in patients with SAB remain unclear. Therefore, we investigated 30-day all-cause mortality in patients with and… Continue reading Outcome of Community-Acquired Staphylococcus aureus Bacteraemia in Patients with Diabetes
Objectively Measured Walking Duration and Sedentary Behaviour and Four-Year Mortality
in Older People: by Jochen Klenk, Dhayana Dallmeier, Michael Dieter Denkinger, Kilian Rapp, Wolfgang Koenig, Dietrich Rothenbacher, ActiFE Study Group Background Physical activity is an important component of health. Recommendations based on sensor measurements are sparse in older people. The aim of this study was to analyse the effect of objectively measured walking and sedentary… Continue reading Objectively Measured Walking Duration and Sedentary Behaviour and Four-Year Mortality
Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA)
Impact of Endobronchial Ultrasound (EBUS) Training on the Diagnostic Yield of Conventional Transbronchial Needle Aspiration for Lymph Node Stations 4R and 7: by Inderpaul Singh Sehgal, Sahajal Dhooria, Nalini Gupta, Amanjit Bal, Babu Ram, Ashutosh Nath Aggarwal, Digambar Behera, Ritesh Agarwal Background There is sparse literature on whether training in endobronchial ultrasound (EBUS)-guided transbronchial needle… Continue reading Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA)
Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities: The Effect of Sorafenib, Tadalafil and Macitentan Treatments
The Effect of Sorafenib, Tadalafil and Macitentan Treatments on by Nancy S. Saad, Kyle Floyd, Amany A. E. Ahmed, Peter J. Mohler, Paul M. L. Janssen, Mohammad T. Elnakish Multikinase inhibitors (e.g. Sorafenib), phosphodiesterase-5 inhibitors (e.g. Tadalafil), and endothelin-1 receptor blockers (e.g. Macitentan) exert influential protection in a variety of animal models of cardiomyopathy; however,… Continue reading Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities: The Effect of Sorafenib, Tadalafil and Macitentan Treatments
Cryptococcus neoformans is an opportunistic fungal pathogen : Vaccination Strategy
Glucosylceramide Administration as a Vaccination Strategy in Mouse Models of Cryptococcosis: by Visesato Mor, Amir M. Farnoud, Ashutosh Singh, Antonella Rella, Hiromasa Tanno, Keiko Ishii, Kazuyoshi Kawakami, Toshiya Sato, Maurizio Del Poeta Cryptococcus neoformans is an opportunistic fungal pathogen and the causative agent of the disease cryptococcosis. Cryptococcosis is initiated as a pulmonary infection and… Continue reading Cryptococcus neoformans is an opportunistic fungal pathogen : Vaccination Strategy
Asthma-Like Symptoms in Homeless Children
in the Greater Paris Area in 2013: Prevalence, Associated Factors and Utilization of Healthcare Services in the ENFAMS Survey: by Delphine Lefeuvre, Marie-Christine Delmas, Christophe Marguet, Pierre Chauvin, Stéphanie Vandentorren Introduction Asthma remains poorly studied in homeless children. We sought to estimate the prevalence of asthma-like symptoms (ALS) and to identify the factors associated with… Continue reading Asthma-Like Symptoms in Homeless Children
Oseltamivir Treatment for Children with Influenza-Like Illness
in China: A Cost-Effectiveness Analysis: by Kunling Shen, Tengbin Xiong, Seng Chuen Tan, Jiuhong Wu Background Influenza is a common viral respiratory infection that causes epidemics and pandemics in the human population. Oseltamivir is a neuraminidase inhibitor—a new class of antiviral therapy for influenza. Although its efficacy and safety have been established, there is uncertainty… Continue reading Oseltamivir Treatment for Children with Influenza-Like Illness
Scalp Rosacea treated with low dose doxycycline and probiotic therapy
A case of Scalp Rosacea treated with low dose doxycycline and probiotic therapy and literature review on therapeutic options: Abstract Rosacea is a common chronic inflammatory disorder showing a wide range of clinical features such as telangiectasia, erythema, papules, and pustules primarily involving the central part of face (forehead, cheeks and nose) although extra facial… Continue reading Scalp Rosacea treated with low dose doxycycline and probiotic therapy
CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells
CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells: by Meagan O’Brien, Olivier Manches, Craig Wilen, Ramya Gopal, Rumana Huq, Vernon Wu, Nicole Sunseri, Nina Bhardwaj Plasmacytoid dendritic cells (pDC) are innate immune cells that sense viral nucleic acids through endosomal Toll-like receptor (TLR) 7/9 to produce type I interferon… Continue reading CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells
Undergraduate education prepare medical students in ENT
Does current provision of undergraduate education prepare UK medical students in ENT? A systematic literature review: Objective To systematically identify and analyse all published literature relating to the provision of undergraduate education for preparedness in ear, nose and throat (ENT) surgery, as perceived by medical students and clinicians in the UK. Design Systematic literature review.… Continue reading Undergraduate education prepare medical students in ENT
Toxoplasma gondii Prevalence in Meat
Investigating the Determinants of Toxoplasma gondii Prevalence in Meat: A Systematic Review and Meta-Regression: by Simone Belluco, Marzia Mancin, Daniele Conficoni, Giulia Simonato, Mario Pietrobelli, Antonia Ricci Background *Toxoplasma gondii* is one of the most widespread parasites in humans and can cause severe illness in immunocompromised individuals. However, its role in healthy people is probably under-appreciated. The complex epidemiology of this protozoan recognizes several infection routes but consumption of contaminated food is likely to be the predominant one. Among ... περισσότερα »
Outcome of Community-Acquired Staphylococcus aureus Bacteraemia in Patients with Diabetes
A Historical Population-Based Cohort Study: by Jesper Smit, Reimar Wernich Thomsen, Henrik Carl Schønheyder, Henrik Nielsen, Trine Frøslev, Mette Søgaard Background Patients with diabetes (DM) experience increased risk of *Staphylococcus aureus* bacteraemia (SAB), but the prognostic impact of diabetes in patients with SAB remain unclear. Therefore, we investigated 30-day all-cause mortality in patients with and without DM. Methods Population-based medical databases were used to conduct a cohort study of all adult patients with community-acquired SAB in Northern Denmark, 2000–... περισσότερα »
Objectively Measured Walking Duration and Sedentary Behaviour and Four-Year Mortality
in Older People: by Jochen Klenk, Dhayana Dallmeier, Michael Dieter Denkinger, Kilian Rapp, Wolfgang Koenig, Dietrich Rothenbacher, ActiFE Study Group Background Physical activity is an important component of health. Recommendations based on sensor measurements are sparse in older people. The aim of this study was to analyse the effect of objectively measured walking and sedentary duration on four-year mortality in community-dwelling older people. Methods Between March 2009 and April 2010, physical activity of 1271 participants (≥65 years, 56.4% men) from Southern Germany wa...περισσότερα »
Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA)
Impact of Endobronchial Ultrasound (EBUS) Training on the Diagnostic Yield of Conventional Transbronchial Needle Aspiration for Lymph Node Stations 4R and 7: by Inderpaul Singh Sehgal, Sahajal Dhooria, Nalini Gupta, Amanjit Bal, Babu Ram, Ashutosh Nath Aggarwal, Digambar Behera, Ritesh Agarwal Background There is sparse literature on whether training in endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) improves the diagnostic yield of conventional TBNA (cTBNA). Objectives The aim of this study was to evaluate the diagnostic yield of cTBNA before an...περισσότερα »
Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities: The Effect of Sorafenib, Tadalafil and Macitentan Treatments
The Effect of Sorafenib, Tadalafil and Macitentan Treatments on by Nancy S. Saad, Kyle Floyd, Amany A. E. Ahmed, Peter J. Mohler, Paul M. L. Janssen, Mohammad T. Elnakish Multikinase inhibitors (e.g. Sorafenib), phosphodiesterase-5 inhibitors (e.g. Tadalafil), and endothelin-1 receptor blockers (e.g. Macitentan) exert influential protection in a variety of animal models of cardiomyopathy; however, their effects on thyroxin-induced cardiomyopathy have never been investigated. The goal of the present study was to assess the functional impact of these drugs on thyroxin-induced hemodyn...περισσότερα »
Cryptococcus neoformans is an opportunistic fungal pathogen : Vaccination Strategy
Glucosylceramide Administration as a Vaccination Strategy in Mouse Models of Cryptococcosis: by Visesato Mor, Amir M. Farnoud, Ashutosh Singh, Antonella Rella, Hiromasa Tanno, Keiko Ishii, Kazuyoshi Kawakami, Toshiya Sato, Maurizio Del Poeta *Cryptococcus neoformans* is an opportunistic fungal pathogen and the causative agent of the disease cryptococcosis. Cryptococcosis is initiated as a pulmonary infection and in conditions of immune deficiency disseminates to the blood stream and central nervous system, resulting in life-threatening meningoencephalitis. A number of studies have ... περισσότερα »
Therapists, researchers in Lincoln make swallowing easier – Sioux City Journal
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Therapists, researchers in Lincoln make swallowing easier Sioux City Journal Eleven years ago, he said between bites, he went through radiation treatment for larynx cancer. So he knew from experience, as his … «Swallowing is the single-most complex system in the human body,» said Angela Dietsch, who teaches the graduate-level … and more » from […]
Models and standards in sleep research and sleep medicine
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1r8JAHP via IFTTT
Call for nomination for Editor-in-Chief
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1qAFNSA via IFTTT
Issue Information
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1r8Jy2w via IFTTT
In Memoriam
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1qAFM1b via IFTTT
The state of melanoma: challenges and opportunities
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Summary The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas – diagnosis/early detection, prevention, tumor cell dormancy (including metastasis), and […]
Phase I study of pegylated interferon-alpha-2b as an adjuvant therapy in Japanese patients with malignant melanoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Abstract In the adjuvant setting for malignant melanoma, interferon (IFN)-α-2b and pegylated (PEG) IFN-α-2b were approved in several countries including the USA before these were approved in Japan. To resolve the “drug-lag” issue, this phase I study was designed to evaluate the safety and tolerability in Japanese patients with stage II or III malignant melanoma […]
Asthma-Like Symptoms in Homeless Children
in the Greater Paris Area in 2013: Prevalence, Associated Factors and Utilization of Healthcare Services in the ENFAMS Survey: by Delphine Lefeuvre, Marie-Christine Delmas, Christophe Marguet, Pierre Chauvin, Stéphanie Vandentorren Introduction Asthma remains poorly studied in homeless children. We sought to estimate the prevalence of asthma-like symptoms (ALS) and to identify the factors associated with ALS and healthcare service utilisation. Materials and Methods A cross-sectional survey of a random sample of sheltered homeless families was conducted by interviewing 801 pare...περισσότερα »
Oseltamivir Treatment for Children with Influenza-Like Illness
in China: A Cost-Effectiveness Analysis: by Kunling Shen, Tengbin Xiong, Seng Chuen Tan, Jiuhong Wu Background Influenza is a common viral respiratory infection that causes epidemics and pandemics in the human population. Oseltamivir is a neuraminidase inhibitor—a new class of antiviral therapy for influenza. Although its efficacy and safety have been established, there is uncertainty regarding whether influenza-like illness (ILI) in children is best managed by oseltamivir at the onset of illness, and its cost-effectiveness in children has not been studied in China. Objective ... περισσότερα »
Scalp Rosacea treated with low dose doxycycline and probiotic therapy
A case of Scalp Rosacea treated with low dose doxycycline and probiotic therapy and literature review on therapeutic options: Abstract Rosacea is a common chronic inflammatory disorder showing a wide range of clinical features such as telangiectasia, erythema, papules, and pustules primarily involving the central part of face (forehead, cheeks and nose) although extra facial manifestation have been described. We describe a case of rosacea with predominant scalp involvement successfully treated with a 8-week-course of doxycycline 40 mg once a day and probiotic therapy twice a day (B...περισσότερα »
Tryptophan, thiamine, and indole-3-acetic acid exchange between Chlorella sorokiniana and the plant growth-promoting bacterium Azospirillum brasilense
During synthetic mutualistic interactions between the microalga *Chlorella sorokiniana* and the plant growth-promoting bacterium (PGPB) *Azospirillum brasilense*, mutual exchange of resources involved in producing and releasing the phytohormone indole-3-acetic acid (IAA) by the bacterium, using tryptophan and thiamine released by the microalga, were measured. Although increased activities of tryptophan synthase in *C. sorokiniana* and indole pyruvate decarboxylase (IPDC) in *A. brasilense* were observed, we could not detect tryptophan or IAA in the culture medium when both organis...περισσότερα »
Resection of a Posterior Mediastinal Mass: Failed Exploration for Presumed Schwannoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Resection of a Posterior Mediastinal Mass: Lessons Learned from a Failed Exploration for Presumed Schwannoma: [HTML] από springeropen.com [HTML] Completely resected follicular dendritic cell sarcoma of the posterior mediastinum: report of a case R Miyoshi, M Sonobe… – Surgical Case …, 2016 – surgicalcasereports.springeropen. … … to better survival [4]. In our case, adjuvant therapy […]
Cancer chemoresistance; biochemical and molecular aspects
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
: a brief overview via ScienceDirect Publication: European Journal of Pharmaceutical Sciences Publication date: Available online 16 April 2016 Source:European Journal of Pharmaceutical Sciences Author(s): Saeed Kachalaki, Mina Ebrahimi, Leila Mohamed Khosroshahi, Sina Mohammadinejad, Behzad Baradaran The effectiveness of chemotherapy is one of the main challenges in cancer treatment and resistance to classic drugs and […]
Wound healing hydrogels based on a quinolone, hydroxypropyl methylcellulose and biodegradable microfibres
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Development and evaluation of via ScienceDirect Publication: European Journal of Pharmaceutical Sciences Publication date: Available online 16 April 2016 Source:European Journal of Pharmaceutical Sciences Author(s): Chukwuma O. Agubata, Chiadikaobi Okereke, Ifeanyi T. Nzekwe, Remigius I. Onoja, Nicholas C. Obitte Ofloxacin is a synthetic antibiotic of the fluoroquinolone class, with activity against gram-positive and gram-negative bacteria. […]
Outcomes of Sinonasal Cancer Treated With Proton Therapy.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Outcomes of Sinonasal Cancer Treated With Proton Therapy.: Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):377-85 Authors: Dagan R, Bryant C, Li Z, Yeung D, Justice J, Dzieglewiski P, Werning J, Fernandes R, Pirgousis P, Lanza DC, Morris CG, Mendenhall WM Abstract PURPOSE: To report disease outcomes after proton therapy (PT) for sinonasal cancer. […]
Non-canonical WNT5A-ROR2 axis in esophageal adenocarcinoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Non-canonical WNT5A-ROR2 axis in esophageal adenocarcinoma: The mechanism underlying the progression of normal esophageal mucosa to esophageal adenocarcinoma (EAC) remains elusive. WNT5A is a non-canonical WNT, which mainly functions via the receptor tyrosine kinase-like orphan receptor 2 (ROR2), and has an unclear role in carcinogenesis. In this study, we aimed to determine the role of […]
GRHL2 suppresses GLUD1 sensitizing to anoikis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
GRHL2 suppresses GLUD1 sensitizing to anoikis: Resistance to anoikis is a pre-requisite for tumor metastasis. The epithelial-to-mesenchymal transition (EMT) allows tumor cells to evade anoikis. The wound healing regulatory transcription factor Grainyhead-like 2 (GRHL2)suppresses/reverses EMT, accompanied by suppression of the cancer stem cell (CSC) phenotype and by re-sensitization to anoikis. Here, the effects of GRHL2 […]
DUSP4/MKP2 in papillary thyroid cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
DUSP4/MKP2 in papillary thyroid cancer: Ben Ma,1,2,* Rongliang Shi,1–3,* Shuwen Yang,1,2 Li Zhou,1,2 Ning Qu,1,2 Tian Liao,1,2 Yu Wang,1,2Yulong Wang,1,2 Qinghai Ji1,2 1Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, 2Department of Oncology, Shanghai Medical College, 3Department of General Surgery, Fudan University, Minhang Hospital, Shanghai, People’s Republic of China *These authors contributed […]
PER1 plays an important inhibitor in OSCC
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
PER1 plays an important inhibitor in OSCC: Xiao-Juan Fu, Han-Xue Li, Kai Yang, Dan Chen, Hong Tang Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China Background: Accumulating evidence suggests that the abnormal expression of the circadian clock gene PER1 is closely related to the […]
The Truview PCD and the GlideScope Cobalt AVL video-laryngoscopes to the Miller blade for successfully intubating manikins simulating normal and difficult pediatric airways
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
A comparison of Summary Background Video-laryngoscopes provide better glottic visualization, but tracheal intubation times are longer, compared to conventional direct laryngoscopy in adult patients with normal airways. The objective of this randomized crossover study was to compare times to successful tracheal intubation with video-laryngoscope and direct laryngoscopy in manikins simulating infants with normal and abnormal […]
Dextrose-containing intraoperative fluid in neonates
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
a randomized controlled trial: Summary Background Glucose requirement in neonates during surgery and the impact of glucose supplementation on neonatal metabolism remain unclear. Aim This study was designed to identify an appropriate perioperative fluid regimen in neonates which maintains carbohydrate and lipid homeostasis. Methods Forty-five neonates undergoing primary repair of a trachea-esophageal fistula were randomly […]
CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells
CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells: [image: journal.ppat.1005553.g001] by Meagan O’Brien, Olivier Manches, Craig Wilen, Ramya Gopal, Rumana Huq, Vernon Wu, Nicole Sunseri, Nina Bhardwaj Plasmacytoid dendritic cells (pDC) are innate immune cells that sense viral nucleic acids through endosomal Toll-like receptor (TLR) 7/9 to produce type I interferon (IFN) and to differentiate into potent antigen presenting cells (APC). Engagement of TLR7/9 in early endosomes appears to trigger the IRF7 pathway for IFN production whereas ... περισσότερα »
Undergraduate education prepare medical students in ENT
Does current provision of undergraduate education prepare UK medical students in ENT? A systematic literature review: Objective To systematically identify and analyse all published literature relating to the provision of undergraduate education for preparedness in ear, nose and throat (ENT) surgery, as perceived by medical students and clinicians in the UK. Design Systematic literature review. Data sources 5 major databases were searched: MEDLINE, EMBASE, ERIC, Cochrane and Web of Science. The literature search was conducted from February to April 2015. Eligibility criteria for s... περισσότερα »
Candidemia in Cancer Patients
A Retrospective Analysis at a Cancer Center From 2001 to 2014.: [image: wk-health-logo.gif] Introduction: While the global epidemiology of candidemia has been studied in great detail, there are relatively few data available examining the effects of recent changes in antifungal treatment patterns on the susceptibility and species distribution patterns of Candida species. Likewise, there are relatively few data documenting improved outcomes in patients with candidemia. Materials and Methods: We reviewed the charts of all patients at our institution with one or more positive blood c... περισσότερα »
Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Publication date: Available online 16 April 2016 *Source:*Free Radical Biology and Medicine Author(s): Baris Bingol, Morgan Sheng Mitochondrial quality control is central for maintaining a healthy population of mitochondria. Two Parkinson's Disease genes, mitochondrial kinase PINK1 and ubiquitin ligase Parkin, degrade damaged mitochondria though mitophagy. In this pathway, PINK1 senses mitochondrial damage and activates Parkin by phosphorylating Parkin and ubiquitin. Activated Parkin then builds ubiquitin chains on damaged mitochondria to tag them for degradation in lysosomes. USP30...περισσότερα »
In vitro MMC absortion and delivery
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Urbaneja D, Morilla-Grasa A, Jimenez E, Montemayor J, Marcobal N, Aragay C, Gurdiel C, Ortiz P, Antón A from #Medicine via ola Kala on Inoreader http://ift.tt/23GqvxG via IFTTT
Brown–McLean syndrome
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Suwan Y, Teekhasaenee C, Lekhanont K, Supakontanasan W from #Medicine via ola Kala on Inoreader http://ift.tt/1qAyNFq via IFTTT
Infections Leading to Broncholithiasis
A Case Report and Review of All Causes.: [image: wk-health-logo.gif] Broncholithiasis is a condition where there is a presence of broncholiths or calcified masses in the airways. The broncholiths commonly are calcified peribronchial lymph nodes that are formed in response to chronic granulomatous infections. The calcified masses either compress the bronchi or erode through the walls into the lumen. They then may be aspirated or expectorated (lithoptysis). Infections with bacteria and fungi have been associated with the development of broncholiths. We present a case of histoplasma... περισσότερα »
Journal of Voice
Voice Range Profile and Health-related Quality of Life Measurements Following Voice Rehabilitation After Radiotherapy; a Randomized Controlled Study Publication date: Available online 15 April 2016 *Source:*Journal of Voice Author(s): Lisa Tuomi, Mia Johansson, Ellen Lindell, Lena Folkestad, Maria Malmerfors, Caterina Finizia Purpose The aim of the present study was to investigate the effects of voice rehabilitation in patients treated with radiotherapy for laryngeal cancer. Method A total of 42 patients with laryngeal cancer who are treated with radiotherapy with curative intent p... περισσότερα »
Normal or Minor Motor Function Abnormalities Detected by High-resolution Esophageal Manometry.
Long-term Outcomes of Patients With [image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Ravi K, Friesen L, Issaka R, Kahrilas PJ, Pandolfino JE Abstract BACKGROUND & AIMS: High-resolution manometry (HRM) expands recognition of minor esophageal motor abnormalities, but the clinical significance of these is unclear. We aimed to determine the outcomes of minor esophageal motor abnormalities. METHODS: We reviewed HRM tracings from patients who underwent esophageal manometry at Northwestern Memorial Hospital from July 2004 through October 2005 by using the Chicago classification...περισσότερα »
Duodenal Biopsy Analysis for Celiac Disease During Endoscopy for Gastroesophageal Reflux.
Cost Effectiveness of Routine [image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Yang JJ, Thanataveerat A, Green PH, Lebwohl B Abstract BACKGROUND & AIMS: Some patients with refractory gastroesophageal reflux disease (GERD) actually have undiagnosed celiac disease. These patients often undergo an esophagogastroduodenoscopy (EGD) to determine the etiology and severity of GERD. Performing routine duodenal biopsy analysis during an EGD could identify patients with celiac disease. We evaluated the cost effectiveness of this approach. METHODS: We performed a systematic search o...περισσότερα »
Peripheral vasoconstriction induced by beta-blockers
a systematic review and a network meta-analysis.: Abstract Aim Peripheral vasoconstriction has long been described as a vascular adverse effect of beta-blockers. Whether beta-blockers should be avoided in patients with peripheral vascular disease depends on pharmacological properties (e.g. preferential binding to β1-adrenoreceptors or intrinsic sympathomimetic activity). However, this has not been confirmed in experimental studies. We performed a network meta-analysis in order to assess the comparative risk of peripheral vasoconstriction of different beta-blockers. Method We searc...περισσότερα »
Resection of a Posterior Mediastinal Mass: Failed Exploration for Presumed Schwannoma
Resection of a Posterior Mediastinal Mass: Lessons Learned from a Failed Exploration for Presumed Schwannoma: [HTML] από springeropen.com [HTML] Completely *resected *follicular dendritic cell sarcoma of the *posterior mediastinum*: report of a case R Miyoshi, M Sonobe… - Surgical Case …, 2016 - surgicalcasereports.springeropen. … *...* to better survival [4]. In our case, adjuvant therapy was not performed because the *tumor* was completely *resected* without any *...* 2015;23:732–4.View ArticlePubMed; Lee BE, Korst RJ, Taskin M. Right pneumonectomy for *resection* of a *posteri...περισσότερα »
Cancer chemoresistance; biochemical and molecular aspects
: a brief overview via ScienceDirect Publication: European Journal of Pharmaceutical Sciences Publication date: Available online 16 April 2016 *Source:*European Journal of Pharmaceutical Sciences Author(s): Saeed Kachalaki, Mina Ebrahimi, Leila Mohamed Khosroshahi, Sina Mohammadinejad, Behzad Baradaran The effectiveness of chemotherapy is one of the main challenges in cancer treatment and resistance to classic drugs and traditional treatment processes is an obstacle to this goal. Drug resistance that may be inherent or adventitious can cause poor treatment outcome and tumor relapse. In ... περισσότερα »
Wound healing hydrogels based on a quinolone, hydroxypropyl methylcellulose and biodegradable microfibres
Development and evaluation of via ScienceDirect Publication: European Journal of Pharmaceutical Sciences Publication date: Available online 16 April 2016 *Source:*European Journal of Pharmaceutical Sciences Author(s): Chukwuma O. Agubata, Chiadikaobi Okereke, Ifeanyi T. Nzekwe, Remigius I. Onoja, Nicholas C. Obitte Ofloxacin is a synthetic antibiotic of the fluoroquinolone class, with activity against gram-positive and gram-negative bacteria. Wound healing involves a complex interaction of cells and processes which can be improved using appropriate wound- dressing materials. The aim of... περισσότερα »
Outcomes of Sinonasal Cancer Treated With Proton Therapy.
Outcomes of Sinonasal Cancer Treated With Proton Therapy.: Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):377-85 Authors: Dagan R, Bryant C, Li Z, Yeung D, Justice J, Dzieglewiski P, Werning J, Fernandes R, Pirgousis P, Lanza DC, Morris CG, Mendenhall WM Abstract PURPOSE: To report disease outcomes after proton therapy (PT) for sinonasal cancer. METHODS AND MATERIALS: Eighty-four adult patients without metastases received primary (13%) or adjuvant (87%) PT for sinonasal cancers (excluding melanoma, sarcoma, and lymphoma). Common histologies were olfactory neuroblastoma (23%), squa... περισσότερα »
Non-canonical WNT5A-ROR2 axis in esophageal adenocarcinoma
Non-canonical WNT5A-ROR2 axis in esophageal adenocarcinoma: The mechanism underlying the progression of normal esophageal mucosa to esophageal adenocarcinoma (EAC) remains elusive. WNT5A is a non-canonical WNT, which mainly functions via the receptor tyrosine kinase-like orphan receptor 2 (ROR2), and has an unclear role in carcinogenesis. In this study, we aimed to determine the role of WNT5A/ROR2 signaling in EAC. Analysis of WNT5A and ROR2 expression patterns in healthy controls, Barrett's and EAC patients' esophageal clinical specimens as well as in various esophageal cell lines... περισσότερα »
GRHL2 suppresses GLUD1 sensitizing to anoikis
GRHL2 suppresses GLUD1 sensitizing to anoikis: Resistance to anoikis is a pre-requisite for tumor metastasis. The epithelial-to-mesenchymal transition (EMT) allows tumor cells to evade anoikis. The wound healing regulatory transcription factor Grainyhead-like 2 (GRHL2)suppresses/reverses EMT, accompanied by suppression of the cancer stem cell (CSC) phenotype and by re-sensitization to anoikis. Here, the effects of GRHL2 upon intracellular metabolism in the context of reversion of the EMT/CSC phenotype, with a view toward understanding how these effects promote anoikis sensitivity w...περισσότερα »
DUSP4/MKP2 in papillary thyroid cancer
DUSP4/MKP2 in papillary thyroid cancer: Ben Ma,1,2,* Rongliang Shi,1–3,* Shuwen Yang,1,2 Li Zhou,1,2 Ning Qu,1,2 Tian Liao,1,2 Yu Wang,1,2Yulong Wang,1,2 Qinghai Ji1,2 1Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, 2Department of Oncology, Shanghai Medical College, 3Department of General Surgery, Fudan University, Minhang Hospital, Shanghai, People’s Republic of China *These authors contributed equally to this work *Abstract: *The study was performed to retrospectively analyze the correlation of dual specificity phosphatase 4 (*DUSP4*) expression...περισσότερα »
PER1 plays an important inhibitor in OSCC
PER1 plays an important inhibitor in OSCC: Xiao-Juan Fu, Han-Xue Li, Kai Yang, Dan Chen, Hong Tang Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China *Background: *Accumulating evidence suggests that the abnormal expression of the circadian clock gene *PER1* is closely related to the development and progression of cancer. However, the exact molecular mechanism by which the abnormal expression of *PER1* induces carcinogenesis is unclear. This study was conducted to investigate the alt...περισσότερα »
The Truview PCD and the GlideScope Cobalt AVL video-laryngoscopes to the Miller blade for successfully intubating manikins simulating normal and difficult pediatric airways
A comparison of Summary Background Video-laryngoscopes provide better glottic visualization, but tracheal intubation times are longer, compared to conventional direct laryngoscopy in adult patients with normal airways. The objective of this randomized crossover study was to compare times to successful tracheal intubation with video-laryngoscope and direct laryngoscopy in manikins simulating infants with normal and abnormal airways. Methods Thirty experienced pediatric anesthesia practitioners performed tracheal intubation in three distinct manikins simulating infants with (i) a norm... περισσότερα »
Dextrose-containing intraoperative fluid in neonates
a randomized controlled trial: Summary Background Glucose requirement in neonates during surgery and the impact of glucose supplementation on neonatal metabolism remain unclear. Aim This study was designed to identify an appropriate perioperative fluid regimen in neonates which maintains carbohydrate and lipid homeostasis. Methods Forty-five neonates undergoing primary repair of a trachea-esophageal fistula were randomly allocated into three groups. During surgery, the neonates received either 1% dextrose in Ringer lactate (RL) (group D1) at 10 ml·kg−1·h−1, or 2% dextrose in RL (grou... περισσότερα »
Yeast-containing feed additive alters gene expression profiles associated with innate immunity in whole blood of a rodent model
Yeast-containing feed additive alters gene expression profiles associated with innate immunity in whole blood of a rodent model: Feeding a yeast-containing additive (YCA; OmniGen-AF) improves immune responses in ruminant livestock and reduces subsequent production losses. The objective was to identify molecular pathways by which dietary YCA may modify immune responses using a rodent model. Thirty-seven healthy, unchallenged CD rats received a diet containing 0 (control; *n* = 5, only 28 d), 0.5% (*n* = 15) or 1% (*n* = 17) YCA for 7 (*n* = 4/group), 14 (*n* = 3 or 4/group), 21 (*n*...περισσότερα »
Salivary agglutinin is the major component in human saliva that modulates the lectin pathway of the complement system
Salivary agglutinin is the major component in human saliva that modulates the lectin pathway of the complement system: Saliva interacts with blood after mucosal damage or leakage of gingival crevicular fluid. Surface-adsorbed salivary agglutinin (SAG) activates the lectin pathway (LP) of the complement system via mannose-binding lectin, while SAG in solution inhibits complement activation. In the present study we investigated if, next to SAG, whole and glandular saliva itself and other salivary glycoproteins activate or inhibit the LP. Complement activation was measured by detectin... περισσότερα »
Use of Lumbar Perforator Recipient Vessels for Salvage Chest Wall Reconstruction: A Case Report
Use of Lumbar Perforator Recipient Vessels for Salvage Chest Wall Reconstruction: A Case Report: [image: image] Summary: Abdominal-based free flaps are commonly used for breast reconstruction, and the internal mammary or thoracodorsal vessels are typically used as recipient sites. Conversely, free tissue transfer is less commonly used for chest wall reconstruction in the setting of chest wall recurrence, in part, because of a paucity of recipient vessels. Here, we describe a case of a 68-year-old female smoker with metastatic breast cancer, who presented with a chest wall recurrenc...περισσότερα »
Poor secretion of transplanted submandibular glands (SMGs)
Carbachol improves the secretion of transplanted submandibular glands during the latent period after microvascular autologous transplantation for severe keratoconjunctivitis sicca via Oral and Maxillofacial Surgery Publication date: Available online 16 April 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): X.-J. Liu, M. Li, J.-Z. Su, Z. Wang, Z. Xie, G.-Y. Yu Poor secretion of transplanted submandibular glands (SMGs) during the latent period may cause duct obstruction and affects the surgical outcome. The objective of this study was to investigate the ef... περισσότερα »
Hereditary gingival fibromatosis (HGF)
Ultrastructural evaluation of gingival connective tissue in hereditary gingival fibromatosis via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 16 April 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Sabina Pena B. Pêgo, Paulo Rogério de Faria, Luis Antônio N. Santos, Ricardo D. Coletta, Sibele Nascimento de Aquino, Hercílio Martelli-Júnior ObjectiveTo describe the ultrastructural features of hereditary gingival fibromatosis (HGF)-affected family members and compare these microscopic findings w... περισσότερα »
Epithelial cysts associated with alloplastic implants after repair of orbital fractures: a systematic review and four new cases
Epithelial cysts associated with alloplastic implants after repair of orbital fractures: a systematic review and four new cases: Abstract An epithelial cyst is a rare and often late complication of long-term alloplastic implants, which has the potential to lead to further complications and harm to patients. We made a systematic review of papers published during the past 30 years about the mechanisms and clinical characteristics formation of epithelial cysts after repair of an orbital fracture by searching PubMed, Medline, and Web of Science to collect all related case reports an... περισσότερα »
Adjunctive minocycline microspheres
Adjunctive minocycline microspheres: The aim of this study was to compare the effects of adjunctive Minocycline HCl Microspheres (Arestin) with debridement alone on the levels of 40 subgingival bacterial species in the treatment of peri-implantitis. Reseachers recruited 208 subjects (from 11 centers in the USA) with at least 1 implant with peri-implantitis and randomized to receive either mechanical debridement alone (n=104) or mechanical debridement followed by Arestin (1 mg) (n=104) at baseline and day 90.
Fractionated Boron Neutron Capture Therapy in Locally Recurrent HNC
A Prospective Phase I/II Trial.: Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):396-403 Authors: Wang LW, Chen YW, Ho CY, Hsueh Liu YW, Chou FI, Liu YH, Liu HM, Peir JJ, Jiang SH, Chang CW, Liu CS, Lin KH, Wang SJ, Chu PY, Lo WL, Kao SY, Yen SH Abstract PURPOSE: To investigate the efficacy and safety of fractionated boron neutron capture therapy (BNCT) for recurrent head and neck (H&N) cancer after photon radiation therapy. METHODS AND MATERIALS: In this prospective phase 1/2 trial, 2-fraction BNCT with intravenous L-boronophenylalanine (L-BPA, 400 mg/kg) was administered at a 2... περισσότερα »
Assessment of resection margin status in head and neck cancer
Third party via ScienceDirect Publication: Oral Oncology Publication date: June 2016 *Source:*Oral Oncology, Volume 57 Author(s): Amy Ransohoff, Douglas Wood, A. Solomon Henry, Vasu Divi, A. Colevas BackgroundDefinitive assessment of primary site margin status following resection of head and neck cancer is necessary for prognostication, treatment determination and qualification for clinical trials. This retrospective analysis determined how often an independent reviewer can assess primary tumor margin status of head and neck cancer resections based on review of the pathology report, ...περισσότερα »
Phase I study of pegylated interferon-alpha-2b as an adjuvant therapy in Japanese patients with malignant melanoma
Abstract In the adjuvant setting for malignant melanoma, interferon (IFN)-α-2b and pegylated (PEG) IFN-α-2b were approved in several countries including the USA before these were approved in Japan. To resolve the "drug-lag" issue, this phase I study was designed to evaluate the safety and tolerability in Japanese patients with stage II or III malignant melanoma who had undergone surgery, by treating with PEG IFN-α-2b. As with a previously reported phase III study, patients were to receive PEG IFN-α-2b 6 μg/kg per week s.c. during an 8-week induction phase, followed by a maintenance... περισσότερα »
Possible advantage of imiquimod and diphenylcyclopropenone combined treatment versus diphenylcyclopropenone alone: An observational study of nonresponder patients with alopecia areata
Abstract The topical contact sensitiser diphenylcyclopropenone (DCP) remains one of the most effective treatment modalities for alopecia areata (AA). However, some patients (nonresponders) do not respond to this treatment because they do not have an allergic reaction to DCP. The aim of this study was to investigate the potential role of imiquimod in inducing an allergic reaction to DCP in nonresponders. In all, 20 nonresponders were recruited from a group of DCP-treated AA patients. Of these patients, 10 were treated with DCP and topical imiquimod and 10 were treated with DCP alone...περισσότερα »
Second-line recurrent and/or metastatic HNSCC : Afatinib versus methotrexate
Afatinib versus methotrexate in older patients with second-line recurrent and/or metastatic head and neck squamous cell carcinoma: subgroup analysis of the LUX-Head & Neck 1 trial.: Ann Oncol. 2016 Apr 15; Authors: Clement PM, Gauler T, Machiels JH, Haddad RI, Fayette J, Licitra LF, Tahara M, Cohen EE, Cupissol D, Grau JJ, Guigay J, Caponigro F, de Castro G, de Souza Viana L, Keilholz U, Del Campo JM, Cong XJ, Ehrnrooth E, Vermorken JB, LUX-H&N 1 investigators Abstract BACKGROUND: In the phase III LUX-Head & Neck 1 (LHN1) trial, afatinib significantly improved progression-free sur... περισσότερα »
Improving proton therapy by metal-containing nanoparticles
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Schlathölter T, Eustache P, Porcel E, Salado D, Stefancikova L, Tillement O, Lux F, Mowat P, Biegun AK, van Goethem MJ, Remita H, Lacombe S from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SlXEq2 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Lecithin-based mixed polymeric micelles containing quercetin
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Chen LC, Chen YC, Su CY, Hong CS, Ho HO, Sheu MT from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1VcroJr via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
An rGO based FRET sensor for highly sensitive detection of MMP2
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Xi G, Wang X, Chen T from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SlXE9s via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Potato chips lead Washington woman to cancer diagnosis – WOWT
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
WOWT Potato chips lead Washington woman to cancer diagnosis WOWT However, after a test for strep throat came back negative, her doctor decided to biopsy the swollen tonsil. Moore had throat cancer. «It’s called squamous cell carcinoma on my left tonsil,» Moore told CNN. Squamous cell carcinoma has a strong … and more » from […]
Genetics of vestibular disorders: pathophysiological insights.
Genetics of vestibular disorders: pathophysiological insights.: J Neurol. 2016 Apr;263(Suppl 1):45-53 Authors: Frejo L, Giegling I, Teggi R, Lopez-Escamez JA, Rujescu D Abstract The two most common vestibular disorders are motion sickness and vestibular migraine, affecting 30 and 1-2 % of the population respectively. Both are related to migraine and show a familial trend. Bilateral vestibular hypofunction is a rare condition, and some of patients also present cerebellar ataxia and neuropathy. We present recent advances in the genetics of vestibular disorders with familial aggregati...περισσότερα »
Central Nervous Activity upon Systemic Salicylate Application in Kanamycin-Induced Hearing Loss
Central Nervous Activity upon Systemic Salicylate Application in Animals with Kanamycin-Induced Hearing Loss - A Manganese-Enhanced MRI (MEMRI) Study: by Moritz Gröschel, Romy Götze, Susanne Müller, Arne Ernst, Dietmar Basta This study investigated the effect of systemic salicylate on central auditory and non-auditory structures in mice. Since cochlear hair cells are known to be one major target of salicylate, cochlear effects were reduced by using kanamycin to remove or impair hair cells. Neuronal brain activity was measured using the non-invasive manganese-enhanced magnetic reson... περισσότερα »
Gait & Posture
Plantar pressure measurements and running-related injury: A systematic review of methods and possible associations Publication date: June 2016 *Source:*Gait & Posture, Volume 47 Author(s): Robert Mann, Laurent Malisoux, Axel Urhausen, Kenneth Meijer, Daniel Theisen Pressure-sensitive measuring devices have been identified as appropriate tools for measuring an array of parameters during running. It is unclear which biomechanical characteristics relate to running-related injury (RRI) and which data-processing techniques are most promising to detect this relationship. This systema...περισσότερα »
Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond
Publication date: Available online 16 April 2016 Source:Free Radical Biology and Medicine Author(s): Baris Bingol, Morgan Sheng Mitochondrial quality control is central for maintaining a healthy population of mitochondria. Two Parkinson’s Disease genes, mitochondrial kinase PINK1 and ubiquitin ligase Parkin, degrade damaged mitochondria though mitophagy. In this pathway, PINK1 senses mitochondrial damage and activates Parkin… Continue reading Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond
Tryptophan, thiamine, and indole-3-acetic acid exchange between Chlorella sorokiniana and the plant growth-promoting bacterium Azospirillum brasilense
During synthetic mutualistic interactions between the microalga Chlorella sorokiniana and the plant growth-promoting bacterium (PGPB) Azospirillum brasilense, mutual exchange of resources involved in producing and releasing the phytohormone indole-3-acetic acid (IAA) by the bacterium, using tryptophan and thiamine released by the microalga, were measured. Although increased activities of tryptophan synthase in C. sorokiniana and indole… Continue reading Tryptophan, thiamine, and indole-3-acetic acid exchange between Chlorella sorokiniana and the plant growth-promoting bacterium Azos... περισσότερα »
Spatial and niche-based ecological processes drive the distribution of endophytic Sebacinales in soil and root of grassland communities
The interest in endophytic sebacinalean communities has been increasing during the last decade due to the increased knowledge about their symbiotic life style and potential role for ecosystem functioning. Although they are present in many ecosystems, their abundance in individual plant roots is very limited. This fact affects their study: they are difficult to isolate… Continue reading Spatial and niche-based ecological processes drive the distribution of endophytic Sebacinales in soil and root of grassland communities
Compartmentalization of gypsum and halite associated with cyanobacteria in saline soil crusts
The interface between biological and geochemical components in surface crust of a saline soil was investigated using X-Ray Diffraction (XRD), and variable pressure scanning electron microscopy (SEM) in combination with Energy Dispersive X-ray Spectrometry (EDS). Mineral compounds such as halite and gypsum were identified crystallized around filaments of cyanobacteria. A total of 92 genera were… Continue reading Compartmentalization of gypsum and halite associated with cyanobacteria in saline soil crusts
Phylogenetic Diversity and Ecophysiology of Candidate Phylum Saccharibacteria in Activated Sludge
Candidate phylum Saccharibacteria (former TM7) are abundant and widespread in nature, but little is known about their ecophysiology and detailed phylogeny. In this study phylogeny, morphology, and ecophysiology of Saccharibacteria were investigated in activated sludge from nine wastewater treatment plants (WWTPs) from Japan and Denmark using the full-cycle 16S rRNA approach and microautoradiography (MAR) –… Continue reading Phylogenetic Diversity and Ecophysiology of Candidate Phylum Saccharibacteria in Activated Sludge
In vitro MMC absortion and delivery
Urbaneja D, Morilla-Grasa A, Jimenez E, Montemayor J, Marcobal N, Aragay C, Gurdiel C, Ortiz P, Antón A from #Medicine via ola Kala on Inoreader http://ift.tt/23GqvxG Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/20P3TWO via IFTTT
Brown–McLean syndrome
Suwan Y, Teekhasaenee C, Lekhanont K, Supakontanasan W from #Medicine via ola Kala on Inoreader http://ift.tt/1qAyNFq Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SoG6wK via IFTTT
GSE80353 MicroRNAs control mRNA fate by compartmentalizing mRNAs based on 3’UTR length
Contributors : Chong Tang ; Ying Zhang ; Tian Yu ; Wei Yan Series Type : Expression profiling by high throughput sequencing Organism : Mus musculus Introduction: we conduct comprehensive transcriptomic profiling analyses on three spermatogenic cell types (pachytene spermatocytes, round and elongating spermatids) purified from adult mouse testes using RNA-seq, and we determined not… Continue reading GSE80353 MicroRNAs control mRNA fate by compartmentalizing mRNAs based on 3’UTR length
GSE76314 Human Induced Pluripotent Stem Cells Recapitulate Breast Cancer Patients’ Predilection to Doxoru bicin-Induced Cardiotoxicity
Contributor : Paul Burridge Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens Doxorubicin (Adriamycin) is an anthracycline chemotherapy agent effective in treating a wide range of malignancies1 with a well-established dose-response cardiotoxic side-effect that can lead to heart failure2-4. Even at relatively low cumulative doses of 200–250 mg/m2, the risk… Continue reading GSE76314 Human Induced Pluripotent Stem Cells Recapitulate Breast Cancer Patients’ Predilection to Doxoru bicin-Induced Cardiotoxicity
GSE74595 Innate-like functions of natural killer T cell subsets result from highly divergent gene programs ChIP-seq
Contributors : Isaac Engel ; Grégory Seumois ; Lukas Chavez ; Ashu Chawla ; Brandie White ; Dennis Mock ; Pandurangan Vijayanand ; Mitchell Kronenberg Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Mus musculus Natural killer T (NKT) cells have immune stimulatory or inhibitory effects on the immune response that… Continue reading GSE74595 Innate-like functions of natural killer T cell subsets result from highly divergent gene programs ChIP-seq
Possible advantage of imiquimod and diphenylcyclopropenone combined treatment versus diphenylcyclopropenone alone: An observational study of nonresponder patients with alopecia areata
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract The topical contact sensitiser diphenylcyclopropenone (DCP) remains one of the most effective treatment modalities for alopecia areata (AA). However, some patients (nonresponders) do not respond to this treatment because they do not have an allergic reaction to DCP. The aim of this study was to investigate the potential role of imiquimod in inducing an […]
Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 16 April 2016 Source:Free Radical Biology and Medicine Author(s): Baris Bingol, Morgan Sheng Mitochondrial quality control is central for maintaining a healthy population of mitochondria. Two Parkinson’s Disease genes, mitochondrial kinase PINK1 and ubiquitin ligase Parkin, degrade damaged mitochondria though mitophagy. In this pathway, PINK1 senses mitochondrial damage and activates Parkin […]
Spatial and niche-based ecological processes drive the distribution of endophytic Sebacinales in soil and root of grassland communities
The interest in endophytic sebacinalean communities has been increasing during the last decade due to the increased knowledge about their symbiotic life style and potential role for ecosystem functioning. Although they are present in many ecosystems, their abundance in individual plant roots is very limited. This fact affects their study: they are difficult to isolate and to detect in root DNA samples. To advance knowledge of the forces that shape their distribution, we approached the parallel study of sebacinalean communities in roots and soil of a grassland. Using a small-scale s... περισσότερα »
Compartmentalization of gypsum and halite associated with cyanobacteria in saline soil crusts
The interface between biological and geochemical components in surface crust of a saline soil was investigated using X-Ray Diffraction (XRD), and variable pressure scanning electron microscopy (SEM) in combination with Energy Dispersive X-ray Spectrometry (EDS). Mineral compounds such as halite and gypsum were identified crystallized around filaments of cyanobacteria. A total of 92 genera were identified from the bacterial community based on 16S gene pyrosequencing analysis. The occurrence of the gypsum crystals, their shapes and compartmentalization suggested that they separated ...περισσότερα »
Phylogenetic Diversity and Ecophysiology of Candidate Phylum Saccharibacteria in Activated Sludge
Candidate phylum Saccharibacteria (former TM7) are abundant and widespread in nature, but little is known about their ecophysiology and detailed phylogeny. In this study phylogeny, morphology, and ecophysiology of Saccharibacteria were investigated in activated sludge from nine wastewater treatment plants (WWTPs) from Japan and Denmark using the full-cycle 16S rRNA approach and microautoradiography (MAR) - fluorescence *in situ* hybridization (FISH). Phylogenetic analysis showed that Saccharibacteria from all WWTPs were evenly distributed within subdivision 1 and 3 and in a distin...περισσότερα »
