Osteopontin expression is correlated with differentiation and good prognosis in medullary thyroid carcinoma
Osteopontin expression is correlated with differentiation and good prognosis in medullary thyroid carcinoma: Background Osteopontin (OPN) or secreted phosphoprotein 1 (SPP1) is a matricellular glycoprotein whose expression is elevated in various types of cancer and has been shown to be involved in tumourigenesis and metastasis in many malignancies, including follicular cell-derived thyroid carcinomas. Its role in C-cell-derived thyroid lesions and tumours remains to be established. Objective The objective of this study is to clarify the role of OPN expression in the development of...περισσότερα »
BRAF V600E mutations in papillary craniopharyngioma
ENDOCRINE TUMORS: BRAF V600E mutations in papillary craniopharyngioma: Papillary craniopharyngioma (PCP) is an intracranial tumor that results in high levels of morbidity. We recently demonstrated that the vast majority of these tumors harbor the oncogenic *BRAF* V600E mutation. The pathologic diagnosis of PCP can now be confirmed using mutation specific immunohistochemistry and targeted genetic testing. Treatment with targeted agents is now also a possibility in select situations. We recently reported a patient with a multiply recurrent PCP in whom targeting both *BRAF* and MEK re... περισσότερα »
Genetic predictors of thyroid cancer outcome
ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome: Genetic predictors of outcome are reviewed in the context of a disease – cancer – that can be (too) simplistically described as a ‘successful, invasive clone of our own tissues’. Context has many faces that determine a thyroid cancer patient's outcome beyond the influence of genetic markers. There is also plenty of evidence on the prognostic meaning of the interplay between genetics and context/microenvironment factors (encapsulation, degree of invasion, staging, etc.). This review addresses only genetic alterations d... περισσότερα »
A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17 + cell frequency
A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17 + cell frequency: AbstractPatients with HPV-positive oropharyngeal squamous cell carcinomas (OPSCCs) have a better prognosis than patients with non-HPV-induced OPSCC. The role of the immune response in this phenomenon is yet unclear. We studied the number of T cells, regulatory T cells (Tregs), T helper 17 (Th17) cells and IL-17+ non-T cells (mainly granulocytes) in matched HPV-positive and HPV-negative OPSCC cases (*n* = 162). Furthermore, the production of ...περισσότερα »
The Warburg effect in melanoma cells
Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells: Abstract BackgroundThe metabolism of cancer cells is often reprogrammed by dysregulation of metabolic enzymes. Transketolase-like 1 (TKTL1) is a homodimeric transketolase linking the pentose-phosphate pathway with the glycolytic pathway. It is generally silenced at a transcriptional level in somatic tissues. However, in human cancers its expression is associated with *the acquisition of a glycolytic phenotype (the Warburg effect) by cancer cells* that co...περισσότερα »
The novel EZH2 inhibitor, GSK126, suppresses cell migration and angiogenesis via down-regulating VEGF-A
The novel EZH2 inhibitor, GSK126, suppresses cell migration and angiogenesis via down-regulating VEGF-A: Abstract PurposeTo explore the effects and mechanisms of GSK126, a novel inhibitor of histone methyltransferase enhancer of zeste homologue 2, on cancer cell migration. MethodsGastric cancer cell line MGC803 and human lung adenocarcinoma cell line A549 were treated with GSK126 at three doses. Transwell and wound healing assays were conducted to detect cell migration. Human umbilical vein endothelial cells tube formation assay and chick embryo chorioallantoic membrane assay w... περισσότερα »
Is prosopagnosia a clinical feature of heterotopia? Evidence from a single case report
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ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome
Genetic predictors of outcome are reviewed in the context of a disease – cancer – that can be (too) simplistically described as a 'successful, invasive clone of our own tissues'. Context has many faces that determine a thyroid cancer patient's outcome beyond the influence of genetic markers. There is also plenty of evidence on the prognostic meaning of the interplay between genetics and context/microenvironment factors (encapsulation, degree of invasion, staging, etc.). This review addresses only genetic alterations detected by molecular methods in surgically resected specimens, t...περισσότερα »
ENDOCRINE TUMORS: BRAF V600E mutations in papillary craniopharyngioma
Papillary craniopharyngioma (PCP) is an intracranial tumor that results in high levels of morbidity. We recently demonstrated that the vast majority of these tumors harbor the oncogenic *BRAF* V600E mutation. The pathologic diagnosis of PCP can now be confirmed using mutation specific immunohistochemistry and targeted genetic testing. Treatment with targeted agents is now also a possibility in select situations. We recently reported a patient with a multiply recurrent PCP in whom targeting both *BRAF* and MEK resulted in a dramatic therapeutic response with a marked anti-tumor imm... περισσότερα »
Osteopontin expression is correlated with differentiation and good prognosis in medullary thyroid carcinoma
Background Osteopontin (OPN) or secreted phosphoprotein 1 (SPP1) is a matricellular glycoprotein whose expression is elevated in various types of cancer and has been shown to be involved in tumourigenesis and metastasis in many malignancies, including follicular cell-derived thyroid carcinomas. Its role in C-cell-derived thyroid lesions and tumours remains to be established. Objective The objective of this study is to clarify the role of OPN expression in the development of medullary thyroid carcinoma (MTC). Methods OPN expression was analysed in a series of 116 MTCs by immuno...περισσότερα »
Reduction in daily hydrocortisone dose improves bone health in primary adrenal insufficiency
Objective Individuals with primary adrenal insufficiency (PAI) or congenital adrenal hyperplasia (CAH) receive life-long glucocorticoid (GC) replacement therapy. Current daily GC doses are still higher than the reported adrenal cortisol production rate. This GC excess could result in long-term morbidities such as osteoporosis. No prospective trials have investigated the long-term effect of GC dose changes in PAI and CAH patients. Methods This is a prospective and longitudinal study including 57 subjects with PAI (42 women) and 33 with CAH (21 women). Bone mineral density (BMD) w... περισσότερα »
Clinicopathological predictive factors in the early remission of corticotroph pituitary macroadenomas in a tertiary referral centre
Objective Corticotroph macroadenomas are a rare cause of Cushing's disease (CD), but their properties are not well-recognised. The aim of this study was to evaluate the clinical and pathological aspects of corticotroph macroadenomas with particular emphasis on proliferation markers and their associations with the efficacy of surgical treatment. Design A prospective cohort study was conducted in a tertiary referral centre in Poland. Methods In total, 59 patients with CD (20 macroadenomas and 39 microadenomas) were included in this study. Hormonal and imaging parameters, histopa...περισσότερα »
Sonidegib (LDE225), an oral inhibitor of hedgehog pathway signaling, in healthy subjects and in patients with advanced solid tumors
Population pharmacokinetics of sonidegib (LDE225), an oral inhibitor of hedgehog pathway signaling, in healthy subjects and in patients with advanced solid tumors: Abstract PurposeSonidegib (Odomzo) selectively inhibits smoothened and suppresses the growth of hedgehog pathway-dependent tumors. A population pharmacokinetic (PK) analysis of sonidegib in healthy subjects and patients with advanced solid tumors was conducted to characterize PK, determine variability, and estimate covariate effects. MethodsPK data from five phase 1 or 2 studies (*N* = 436) in the dose range from ...περισσότερα »
Quantitative imaging of magnesium distribution at single-cell resolution in brain tumors and infiltrating tumor cells with secondary ion mass spectrometry (SIMS)
Quantitative imaging of magnesium distribution at single-cell resolution in brain tumors and infiltrating tumor cells with secondary ion mass spectrometry (SIMS): AbstractGlioblastoma multiforme (GBM) is one of the deadliest forms of human brain tumors. The infiltrative pattern of growth of these tumors includes the spread of individual and/or clusters of tumor cells at some distance from the main tumor mass in parts of the brain protected by an intact blood–brain-barrier. Pathophysiological studies of GBM could be greatly enhanced by analytical techniques capable of in situ single...περισσότερα »
Primary intracranial soft tissue sarcomas
Primary intracranial soft tissue sarcomas in children, adolescents, and young adults: single institution experience and review of the literature: AbstractThere is a paucity of literature reporting the outcome of intracranial sarcomas (IS) in children, adolescents, and young adults (CAYA). A multimodal therapeutic approach is commonly used, with no well-established treatment consensus. We conducted a retrospective review of CAYA with IS, treated at our institution, to determine their clinical findings, treatments, and outcomes. Immunohistochemistry (PDGFRA and EGFR) and DNA sequenci...περισσότερα »
Randomised clinical trial: alginate (Gaviscon Advance) vs. placebo as add-on therapy in reflux patients with inadequate response to a once daily proton pump inhibitor
Summary Background Many reflux patients remain symptomatic on a standard dose of proton pump inhibitor (PPI). Alginates decrease the number of reflux events by forming a raft on top of the stomach content and thus offer a supplemental mechanism of action to acid suppression. Aim To assess the efficacy of an alginate (Gaviscon Advance, Reckitt Benckiser, Slough, UK) on reflux symptoms in patients with persistent symptoms despite once daily PPI. Methods This was a multicentre, randomised, placebo-controlled, 7-day double-blind trial preceded by a 7-day run-in period. Reflux sympt... περισσότερα »
Fear of cancer recurrence
Fear of cancer recurrence in survivor and caregiver dyads: differences by sexual orientation and how dyad members influence each other: Abstract PurposeThe purpose of this study was to identify explanatory factors of fear of recurrence (FOR) in breast cancer survivors of different sexual orientations and their caregivers and to assess the directionality in the survivor and caregiver dyads’ FOR. MethodsWe recruited survivors of non-metastatic breast cancer of different sexual orientations and invited their caregivers into this study. Using a telephone survey, we collected data f... περισσότερα »
TERT Promoter Mutations in Thyroid Cancer
TERT Promoter Mutations in Thyroid Cancer: AbstractTwo mutations (C228T and C250T) in the promoter region of the telomerase reverse transcriptase (*TERT*) have recently been described in different types of cancer including follicular cell-derived thyroid cancer (TC). In this paper, we reviewed the rates of these mutations in different types and subtypes of TC, their association with a number of clinical and histopathological features and outcome of TC, and their potential diagnostic and prognostic roles in TC. The overall rate of these mutations in TC is about 14 % with least preva... περισσότερα »
PD-1/PD-L1 blockade in cancer treatment
PD-1/PD-L1 blockade in cancer treatment: perspectives and issues: AbstractRecent studies showed that tumor cells ‘edit’ host immunity in several ways to evade immune defenses in the tumor microenvironment. This phenomenon is called “cancer immune escape.” One of the most important components in this system is an immunosuppressive co-signal (immune checkpoint) mediated by the PD-1 receptor and its ligand, PD-L1. PD-1 is mainly expressed on activated T cells, whereas PD-L1 is expressed on several types of tumor cells. Preclinical studies have shown that inhibition of the interaction ... περισσότερα »
Tumor vasculogenic mimicry predicts poor prognosis in cancer patients
Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: a meta-analysis: Abstract BackgroundVasculogenic mimicry (VM) is the formation of vascular channels by tumor cells or tumor cell-derived, trans-differentiated cells in highly aggressive, solid tumors. However, the disease features and prognostic value of VM for overall survival of cancer patients remain controversial. MethodTo systematically investigate the roles of VM in cancer progression and its prognostic values, we performed a meta-analysis based on 36 studies (33 eligible articles) including 3609 patien...περισσότερα »
Surgical intestinal manipulation increases gene expression of TrkA, CGRP, and PAR-2 IN dorsal root ganglia in the rat
Abstract Background Surgical handling of the bowel evokes degranulation of peritoneal mast cells (PMC). Nonetheless, role of PMCs in postoperative ileus (POI) is somewhat controversial. We aimed to investigate if intestinal manipulation elicits changes in afferent mediators related to MC activation and alteration of gastrointestinal (GI) motility. Methods Postoperative ileus was induced by intestinal manipulation in Sprague-Dawley rats. Additionally, compound 48/80 (C48/80) and ketotifen were used to modulate MC activity. Rat mast cell protease 6 (RMCP-6, ELISA) release was dete... περισσότερα »
Electrophysiological and morphological changes in colonic myenteric neurons from chemotherapy-treated patients: a pilot study
Abstract Background Patients receiving anticancer chemotherapy experience a multitude of gastrointestinal side-effects. However, the causes of these symptoms are uncertain and whether these therapeutics directly affect the enteric nervous system is unknown. Our aim was to determine whether the function and morphology of myenteric neurons are altered in specimens of the colon from chemotherapy-treated patients. Methods Colon specimens were compared from chemotherapy-treated and non-treated patients following colorectal resections for removal of carcinoma. Intracellular electrophy...περισσότερα »
Is the worsening of psychosocial exposures associated with mental health? Comparing two population-based cross- sectional studies in Spain, 2005–2010
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Aims To analyze whether associations between workplace psychosocial exposures and the mental health of the working population in Spain changed between 2005 and 2010. Methods Two representative samples of the Spanish working population have been analyzed, 2005 (n = 5073) and 2010 (n = 3544). Results In 2010 there was a significant association between poor mental health and exposure […]
Job stress, inflammation, and atherosclerosis: A reflection
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
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Long term symptomatic, functional, and work outcomes of carpal tunnel syndrome among construction workers
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Background The long-term outcomes of carpal tunnel syndrome (CTS) including symptoms, functional status, work disability, and economic impact are unknown. Methods We conducted a retrospective study of 234 active construction workers with medical claims for CTS and 249 workers without CTS claims; non-cases were matched on age, trade, and insurance eligibility. We conducted telephone interviews […]
Central nervous system diseases of organic solvents exposed workers based on nationwide medical surveillance-data in Korea
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Background New light is being shed on the relationship between chronic neurotoxicity of the central nervous system (CNS) and exposure to low-level organic solvents (OS). However, there are few longitudinal studies with a large sample size. Methods A cohort of OS-exposed male workers was selected who had undergone an OS-associated specialized medical check-up at least […]
A Case of Thanatophoric Dysplasia Type I with Fetal Hydrops in the First Trimester
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
During a routine prenatal exam, a 36-year-old female in her third pregnancy was diagnosed with fetal hydrops at 11 weeks of gestation. The pregnancy was monitored with periodic ultrasounds; however, spontaneous resolution was not observed. Amniotic fluid examination at 16 weeks of gestation showed a normal karyotype; however, macrocephaly, a narrow thorax, and shortening of […]
Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn’s disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied […]
Painful Hands and Feet After Cancer Treatment: Inflammation Affecting the Mind-Body Connection [EDITORIALS]
Painful Hands and Feet After Cancer Treatment: Inflammation Affecting the Mind-Body Connection [EDITORIALS]: [image: F1.small.gif]
Patients With Head-and-Neck Cancer Treated With Intensity-Modulated Radiation Therapy
Importance of Radiation Oncologist Experience Among Patients With Head-and-Neck Cancer Treated With Intensity-Modulated Radiation Therapy [Radiation Oncology]: Purpose Over the past decade, intensity-modulated radiation therapy (IMRT) has replaced conventional radiation techniques in the management of head-and-neck cancers (HNCs). We conducted this population-based study to evaluate the influence of radiation oncologist experience on outcomes in patients with HNC treated with IMRT compared with patients with HNC treated with conventional radiation therapy. Methods We identified ra... περισσότερα »
Cerebral Perfusion and Gray Matter Changes Associated With Chemotherapy-Induced Peripheral Neuropathy
[Treatment-Related Complications]: Purpose To investigate the longitudinal relationship between chemotherapy-induced peripheral neuropathy (CIPN) symptoms (sx) and brain perfusion changes in patients with breast cancer. Interaction of CIPN-sx perfusion effects with known chemotherapy-associated gray matter density decrease was also assessed to elucidate the relationship between CIPN and previously reported cancer treatment–related brain structural changes. Methods Patients with breast cancer treated with (n = 24) or without (n = 23) chemotherapy underwent clinical examination and ...περισσότερα »
18FDG-PET/CT on operable squamous cell cancer of esophagus
18FDG-PET/CT on operable squamous cell cancer of esophagus: Sujing Liu,1,2 Hui Zhu,1 Wanghu Li,3 Baijiang Zhang,4 Li Ma,5 Zhijun Guo,6 Yong Huang,3 Pingping Song,4 Jinming Yu,1 Hongbo Guo4 1Department of Radiation Oncology, Shandong Cancer Hospital and Institute, 2Shandong Academy of Medical Sciences, 3Department of Radiology, 4Department of Thoracic Surgery, 5Department of Nuclear Medicine, 6Department of Intensive Care Unit, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, People’s Republic of China *Background:* Fluorodeoxyglucose-positron emission tomography... περισσότερα »
Rapid-maxillary-expansion induced rhinological effects
Rapid-maxillary-expansion induced rhinological effects: a retrospective multicenter study: Abstract Conventional dental-borne rapid maxillary expansion (RME) leads to a widening of the airways, followed by improved nasal breathing. Although combined skeletal–dental appliances are nowadays being inserted increasingly often and provide a force at the center of resistance in the nasomaxillary complex, no study exists so far… Continue reading Rapid-maxillary-expansion induced rhinological effects
The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis
Article REGγ is a component of ubiquitin-independent 20S proteasome that targets many regulatory proteins for degradation. Here the authors show that REGγ is induced in DSS colitis and promotes degradation of IκBɛ, and that REGγ-deficient mice have less NFκB activation and are more resistant to the disease. Nature Communications doi: 10.1038/ncomms10761 Authors: Jinjin Xu, Lei… Continue reading The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis
Novel modification of voice prosthesis
Novel modification of voice prosthesis: Abstract The undesired dilatation of the tracheooesophageal shunt after surgical implantation of voice prosthesis is a typical complication of this procedure. Temporary removal of the prosthesis and reinsertion after a short period of time is a first-line therapeutical option aiming shrinkage of the shunt. Failure of this measure generally is… Continue reading Novel modification of voice prosthesis
Wavefront shaping through emulated curved space in waveguide settings
Article Wavefront shaping is typically carried out outside the medium within which the beam is propagating. Sheng et al. exploit concepts inspired by General Relativity for wavefront shaping within optical waveguide settings, constructing narrow collimated beams and shape-preserving beams accelerating on arbitrary trajectories Nature Communications doi: 10.1038/ncomms10747 Authors: Chong Sheng, Rivka Bekenstein, Hui Liu, Shining… Continue reading Wavefront shaping through emulated curved space in waveguide settings
Totally endoscopic stapes surgery without packing: novel technique bringing most comfort to the patients
Totally endoscopic stapes surgery without packing: novel technique bringing most comfort to the patients: Abstract Many difficulties might be encountered during conventional stapes surgery. However, the good exposure provided by the endoscope can facilitate this procedure. The present study addresses the effectiveness of endoscopic stapes surgery with regard to the operation time and patients’ convenience… Continue reading Totally endoscopic stapes surgery without packing: novel technique bringing most comfort to the patients
Direct single-shot phase retrieval from the diffraction pattern of separated objects
Article Short X-ray pulses from free-electron lasers enable coherent diffractive imaging of noncrystalline objects such as single molecules. Here, the authors reconstructing full image information from a single-shot diffraction pattern by using two sufficiently separated objects to act as references for each other. Nature Communications doi: 10.1038/ncomms10820 Authors: Ben Leshem, Rui Xu, Yehonatan Dallal, Jianwei… Continue reading Direct single-shot phase retrieval from the diffraction pattern of separated objects
Recurrent neck lesions secondary to pyriform sinus fistula
Recurrent neck lesions secondary to pyriform sinus fistula: Abstract Recurrent neck lesions associated with third or fourth branchial arch fistula are much less common than those of second arch and usually present with acute suppurative thyroiditis or neck abscess. Our aim is to describe clinical features, management and treatment outcomes of 64 cases of congenital… Continue reading Recurrent neck lesions secondary to pyriform sinus fistula
Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance
Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance: Abstract Paraneoplastic syndromes are associated with a variety of malignant neoplasms and are systemic and non-metastatic manifestations that develop in a minority of cancer patients. This review examines all published cases of paraneoplastic syndromes associated with neuroendocrine carcinomas of the larynx. There… Continue reading Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic sign... περισσότερα »
TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion
Article ERBB2 overexpression in human breast cancer leads to invasion and metastasis. Here the authors report that ERBB2 induces indirect phosphorylation of TOM1L1 that promotes trafficking of the metalloprotease MT1-MMP to invadopodia, which leads to tumour cell invasion. Nature Communications doi: 10.1038/ncomms10765 Authors: Clément Chevalier, Guillaume Collin, Simon Descamps, Heiani Touaitahuata, Valérie Simon, Nicolas Reymond,… Continue reading TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion
The nasal vestibular body: anatomy, clinical features, and treatment considerations
The nasal vestibular body: anatomy, clinical features, and treatment considerations: Abstract Nasal obstruction is a common presenting complaint, with many possible etiologies. Herein, we provide an introductory anatomic description, clinical relevance, and proposed nomenclature for an underappreciated soft tissue focus in the nasal vestibule—the nasal vestibular body (NVB)—that can contribute to nasal obstruction in a… Continue reading The nasal vestibular body: anatomy, clinical features, and treatment considerations
Panobinostat and epirubicin in solid tumors with a dose expansion in patients with sarcoma
A phase I trial of panobinostat and epirubicin in solid tumors with a dose expansion in patients with sarcoma: This phase I study evaluated combined panobinostat and epirubicin in patients with advanced solid tumors, establishing a MTD, and demonstrating a correlation between neutropenia, PBMC histone acetylation and clinical benefit. In a sarcoma expansion cohort, more than half of patients, having previously failed anthracycline therapy, benefited, suggesting HDAC inhibition reverses resistance.
Gene Fusion May Drive Rare Childhood Brain Tumor
Gene Fusion May Drive Rare Childhood Brain Tumor: Researchers have identified a genetic rearrangement that may drive the development of a rare benign brain tumor in children. The rearrangement, which causes parts of two genes to fuse, may spur the growth of tumors through three distinct biological mechanisms simultaneously, the researchers found. The study focused on angiocentric gliomas, a rare subtype of low-grade pediatric tumors that was first described less than a decade ago. Fewer than 30 cases have been reported in the scientific literature. Based on their findings, the stu... περισσότερα »
Indeterminate Findings on Oncologic PET/CT: What Difference Does PET/MRI Make?
Indeterminate Findings on Oncologic PET/CT: What Difference Does PET/MRI Make?: Abstract BackgroundPositron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) has become the standard of care for the initial staging and subsequent treatment response assessment of many different malignancies. Despite this success, PET/CT is often supplemented by MRI to improve assessment of local tumor invasion and to facilitate detection of lesions in organs with high background FDG uptake. Consequently, PET/MRI has the potential to expand the clinical value... περισσότερα »
Multilocular Thymic Cyst with Follicular Lymphoid Hyperplasia
A Rare Case of Multilocular Thymic Cyst with Follicular Lymphoid Hyperplasia: Radiologic and Histopathologic Features: AbstractMultilocular thymic cysts are rare and acquired lesions induced by an inflammatory arising within the thymus. We report a rare case of multilocular thymic cyst with follicular lymphoid hyperplasia in a 59-year-old female. Chest CT and MRI revealed a large multilocular cystic mass, which contains thick septa and nodules in the thymus. F-18 FDG PET/CT showed almost no FDG uptake of the multilocular cystic mass but moderate FDG uptake of the solid nodules. Ext... περισσότερα »
Use and Overuse of PET to Detect Recurrence and Associations With Survival in Patients With Esophageal Cancers
Lung and Esophageal Cancers: Background: Positron emission tomography (PET) scans are often used in cancer patients for staging, restaging, and monitoring for treatment response. These scans are also often used to detect recurrence in asymptomatic patients, despite a lack of evidence demonstrating improved survival. We sought to evaluate utilization of PET for this purpose and relationships with survival for patients with lung and esophageal cancers. Methods: Using national Surveillance, Epidemiology, and End Results (SEER) and Medicare-linked data, we identified incident patient c...περισσότερα »
Use of Positron Emission Tomography to Detect Recurrence and Associations With Survival in Patients With Lung and Esophageal Cancers
Background: Positron emission tomography (PET) scans are often used in cancer patients for staging, restaging, and monitoring for treatment response. These scans are also often used to detect recurrence in asymptomatic patients, despite a lack of evidence demonstrating improved survival. We sought to evaluate utilization of PET for this purpose and relationships with survival for patients with lung and esophageal cancers. Methods: Using national Surveillance, Epidemiology, and End Results (SEER) and Medicare-linked data, we identified incident patient cases from 2005 to 2009, w... περισσότερα »
A randomized placebo-controlled lovastatin trial for neurobehavioral function in neurofibromatosis I
Abstract Objective Lovastatin has been shown to reverse learning deficits in a mouse model of Neurofibromatosis Type 1 (NF1), a common monogenic disorder caused by a mutation in the Ras-MAPK pathway and associated with learning disabilities. We conducted a randomized double-blind placebo-controlled trial to assess lovastatin's effects on cognition and behavior in patients with NF1. Method Forty-four NF1 patients (mean age 25.7+/−11.6 years; 64% female) were randomly assigned to 14 weeks of lovastatin (*N* = 23; maximum dose of 80 mg/day for adult participants and 40 mg/day for ch...περισσότερα »
Serial Plasma EBV DNA for Nasopharyngeal Carcinoma
Serial Plasma EBV DNA for Nasopharyngeal Carcinoma: *Condition*: Nasopharyngeal Carcinoma *Intervention*: *Sponsor*: The University of Hong Kong Nasopharyngeal carcinoma (NPC) is an endemic malignancy in Southern China, Hong Kong, Taiwan, Singapore and Malaysia. It is highly associated with Epstein-Barr virus (EBV). Radiation therapy alone is indicated for early stage I to II diseases while concurrent chemoradiation is required for more advanced stage III to IVB diseases. Intensity-modulated radiation therapy (IMRT) is the standard radiation technique for NPC, in virtue of... περισσότερα »
Dry Mouth and Sticky Saliva During Radiotherapy
A Study of Patients With Dry Mouth and Sticky Saliva During Radiotherapy: *Condition*: Xerostomia *Interventions*: Device: Visco-ease; Device: Placebo *Sponsors*: NHS Greater Glasgow and Clyde; Lamellar Biomedical Ltd; University of Glasgow ArmsAssigned Interventions Experimental: Visco-ease Visco-ease is a suspension of multilamellar vesicles comprising lipids in ratios which mimic the lipidic composition of endogenous extra-alveolar lamellar bodies. Visco-ease is suspended in physiological saline (0.9% NaCl) to provide a final dose concentration of 19.6 mg/mL. Visco-... περισσότερα »
The Sheffield ACS sickle knife for endoscopic anterior cricoid split
The Sheffield ACS sickle knife for endoscopic anterior cricoid split:
Foot pedal-controlled CT review during functional endoscopic sinus surgery
Foot pedal-controlled CT review during functional endoscopic sinus surgery:
Capnography best practices to improve patient handoff reports
Capnography best practices to improve patient handoff reports: By Kelly Grayson Waveform capnography is an example of EMS as an early adopter of emerging technology. Often, in the hospital, recognition of the value of capnography has not spread beyond the confines of the anesthesiology department. As a patient advocate, use your knowledge of capnography to communicate important patient information to emergency department and intensive care unit staff. You’re picking up a patient in the ED, for a critical care transfer to the ICU at a Level I trauma center an hour away. Your pa... περισσότερα »
Cortical Reorganisation during a 30-Week Tinnitus Treatment Program
Cortical Reorganisation during a 30-Week Tinnitus Treatment Program: by Catherine M. McMahon, Ronny K. Ibrahim, Ankit Mathur Subjective tinnitus is characterised by the conscious perception of a phantom sound. Previous studies have shown that individuals with chronic tinnitus have disrupted sound-evoked cortical tonotopic maps, time-shifted evoked auditory responses, and altered oscillatory cortical activity. The main objectives of this study were to: (i) compare sound-evoked brain responses and cortical tonotopic maps in individuals with bilateral tinnitus and those without tinnit... περισσότερα »
Targeted surgery in the management of tympano-jugular paraganglioma
Observation and partial targeted surgery in the management of tympano-jugular paraganglioma: a contribution to the multioptional treatment: AbstractThe objective of this study was to assess the value of a limited tumor excision in tympano-jugular paragangliomas treated with observation with the goal of preventing, or repairing, a neural (VII cranial nerve) or brain damage and continue an otherwise correct observation. This is a retrospective case review. Each patient was submitted to a complete neuro-radiological work-up for diagnosis including CT, MRI, and angiography if needed o... περισσότερα »
The transnasal VideoPanendoscopy (ViP)
The transnasal VideoPanendoscopy (ViP): diagnostics of the upper aerodigestive tract using an anatomically correct model from the model to the patient: AbstractEndoscopy of the upper aerodigestive tract (UADT) develops rapidly. New endoscopes in combination with special imaging techniques allow complete examinations of the UADT in an ambulatory setting. Therefore, it is necessary to educate and train young physicians in a standardized protocol. A special anatomical training model has been designed to allow a stepwise endoscopy training course. It can be used by specialists who woul...περισσότερα »
Long-term vestibulocochlear functional outcome following retro-sigmoid approach to resection of vestibular schwannoma
Long-term vestibulocochlear functional outcome following retro-sigmoid approach to resection of vestibular schwannoma: AbstractThe objective of this study was to evaluate long-term vestibulocochlear functional outcomes of patients operated for unilateral vestibular schwannoma via the retro-sigmoid approach. Patients who underwent vestibular schwannoma resection via retro-sigmoid approach between 2004 and 2008 at our institution, without prior surgical or radio-surgical therapy were considered to be eligible for this study. Preoperative auditory and vestibular symptoms were assessed... περισσότερα »
Early laryngeal outcome of prolonged intubation using an anatomical tube
Early laryngeal outcome of prolonged intubation using an anatomical tube: a double blind, randomised study: AbstractThe objective of this study was to study the short-term impact on larynx by a newly designed anatomical tube. A prospective randomised trial of a newly designed anatomical tube versus a standard endotracheal tube in patients operated under general anaesthesia for at least 12 h. Seventy adults were included and randomised to either type of tube. The patients were evaluated by means of fibre-optic laryngoscopy and VAS-rating of symptoms on two occasions in the first pos...περισσότερα »
Relationship between nasal septal deformity, symptoms and disease severity in chronic rhinosinusitis
Relationship between nasal septal deformity, symptoms and disease severity in chronic rhinosinusitis: AbstractThe objective of this study was to evaluate the interaction of nasal septal deformity (NSD), including the contribution of septal spurs, with the severity of subjective symptoms, impairment of health-related quality of life (HRQoL) and sinus mucosal hyperplasia in patients with chronic rhinosinusitis (CRS). One hundred seventeen patients with CRS were assigned to three groups with mild, moderate or severe NSD, according to the measured nasal septal angle, including the pres... περισσότερα »
Rapid-maxillary-expansion induced rhinological effects
Rapid-maxillary-expansion induced rhinological effects: a retrospective multicenter study: AbstractConventional dental-borne rapid maxillary expansion (RME) leads to a widening of the airways, followed by improved nasal breathing. Although combined skeletal–dental appliances are nowadays being inserted increasingly often and provide a force at the center of resistance in the nasomaxillary complex, no study exists so far that shows whether this treatment may improve the expansionary effect on the airways. In this study, low-dose computed tomography (CT) images from 31 patients (aver...περισσότερα »
Novel modification of voice prosthesis
Novel modification of voice prosthesis: AbstractThe undesired dilatation of the tracheooesophageal shunt after surgical implantation of voice prosthesis is a typical complication of this procedure. Temporary removal of the prosthesis and reinsertion after a short period of time is a first-line therapeutical option aiming shrinkage of the shunt. Failure of this measure generally is an indication of revision surgery. We present first experiences treating leakage problems with novel modified voice prosthesis without surgical intervention in specified cases. 11 patients (1 female, 10 m... περισσότερα »
Totally endoscopic stapes surgery without packing: novel technique bringing most comfort to the patients
Totally endoscopic stapes surgery without packing: novel technique bringing most comfort to the patients: AbstractMany difficulties might be encountered during conventional stapes surgery. However, the good exposure provided by the endoscope can facilitate this procedure. The present study addresses the effectiveness of endoscopic stapes surgery with regard to the operation time and patients’ convenience and satisfaction. 19 patients underwent endoscopic stapes surgery without packing. 15 patients who experienced the microscopic stapes surgery served as the comparison group. Audiom...περισσότερα »
Recurrent neck lesions secondary to pyriform sinus fistula
Recurrent neck lesions secondary to pyriform sinus fistula: AbstractRecurrent neck lesions associated with third or fourth branchial arch fistula are much less common than those of second arch and usually present with acute suppurative thyroiditis or neck abscess. Our aim is to describe clinical features, management and treatment outcomes of 64 cases of congenital pyriform sinus fistula (PSF). Medical record of these 64 patients (33 males, 31 females) treated at the First Affiliated Hospital of Zhengzhou University from 2011 to 2014 were reviewed. The patients comprised 33 males an...περισσότερα »
Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance
Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance: AbstractParaneoplastic syndromes are associated with a variety of malignant neoplasms and are systemic and non-metastatic manifestations that develop in a minority of cancer patients. This review examines all published cases of paraneoplastic syndromes associated with neuroendocrine carcinomas of the larynx. There are a total of ten patients reported with paraneoplastic syndromes associated with laryngeal neuroendocrine carcinomas in the literature. Of...περισσότερα »
The nasal vestibular body: anatomy, clinical features, and treatment considerations
The nasal vestibular body: anatomy, clinical features, and treatment considerations: AbstractNasal obstruction is a common presenting complaint, with many possible etiologies. Herein, we provide an introductory anatomic description, clinical relevance, and proposed nomenclature for an underappreciated soft tissue focus in the nasal vestibule—the nasal vestibular body (NVB)—that can contribute to nasal obstruction in a subset of patients. This is a small mound of dynamic soft tissue in the lateral aspect of the internal nasal valve, situated inferior and anterior to the head of the... περισσότερα »
The possible preventive effect of caffeic acid phenethyl ester (CAPE) against myringosclerosis
The possible preventive effect of caffeic acid phenethyl ester (CAPE) against myringosclerosis:
The presence of Helicobacter pylori in laryngeal squamous cell carcinoma
The presence of Helicobacter pylori in laryngeal squamous cell carcinoma: AbstractA definitive relationship between *Helicobacter pylori* (HP) and upper respiratory tract disorders has not been established. In this case–control study, we investigated the relationship between HP and laryngeal carcinoma by real-time PCR method in Turkey. 74 subjects were enrolled from patients who were admitted to the Otolaryngology Department. Formalin-fixed-paraffin-embedded tissue samples with laryngeal cancer were used and all samples were evaluated by real-time PCR method. Our study population ...περισσότερα »
Cortical Reorganisation during a 30-Week Tinnitus Treatment Program
Cortical Reorganisation during a 30-Week Tinnitus Treatment Program: by Catherine M. McMahon, Ronny K. Ibrahim, Ankit Mathur Subjective tinnitus is characterised by the conscious perception of a phantom sound. Previous studies have shown that individuals with chronic tinnitus have disrupted sound-evoked cortical tonotopic maps, time-shifted evoked auditory responses, and altered oscillatory cortical activity. The main objectives of this study were to: (i) compare sound-evoked brain responses and cortical tonotopic maps in individuals with bilateral tinnitus and those without tinnit... περισσότερα »
Modulatory Effects of Attention on Lateral Inhibition in the Human Auditory Cortex
Modulatory Effects of Attention on Lateral Inhibition in the Human Auditory Cortex: by Alva Engell, Markus Junghöfer, Alwina Stein, Pia Lau, Robert Wunderlich, Andreas Wollbrink, Christo Pantev Reduced neural processing of a tone is observed when it is presented after a sound whose spectral range closely frames the frequency of the tone. This observation might be explained by the mechanism of lateral inhibition (LI) due to inhibitory interneurons in the auditory system. So far, several characteristics of bottom up influences on LI have been identified, while the influence of top-d... περισσότερα »
Parotitis and Sialendoscopy of the Parotid Gland
Parotitis and Sialendoscopy of the Parotid Gland: [image: gr1.sml] Nonneoplastic disorders of the salivary glands involve inflammatory processes. These disorders have been managed conservatively with antibiotics, warm compresses, massage, sialogogues, and adequate hydration. Up to 40% of patients may have an inadequate response or persistent symptoms. When conservative techniques fail, the next step is operative intervention. Sialendoscopy offers a minimally invasive option for the diagnosis and management of chronic inflammatory disorders of the salivary glands and offers the ... περισσότερα »
Functions of the inner ear in psoriatic arthritis
Functions of the inner ear in psoriatic arthritis: This study aimed to investigate whether there is a negative impact as a result of psoriatic arthritis disease of the inner ear function. AbstractObjective This study aimed to investigate whether there is a negative impact as a result of psoriatic arthritis disease of the inner ear function. Methods Twenty-four successive patients and 38 healthy volunteers, younger than 60 years of age, who were followed up for at least for one year in the outpatient clinics of physical therapy and rehabilitation with the diagnosis of PsA according... περισσότερα »
Primary Tuberculous Osteomyelitis of the Mandible Mimicking a Parotid Gland Abscess
Primary Tuberculous Osteomyelitis of the Mandible Mimicking a Parotid Gland Abscess: AbstractTuberculosis has become a rare disease in the developed countries but it is still a serious problem in the developing countries. Incidence of tuberculous osteomyelitis of the jaw bones is very low. This rare incidence is the primary reason that the lesion gets misdiagnosed many times. Here we report the diagnosis, treatment and follow up of a case which is not a classical presentation of tuberculous osteomyelitis of mandible. Early diagnosis of tuberculous osteomyelitis will certainly reduc...περισσότερα »
The Effect of Mode of Delivery and Hospital Type on Newborn Hearing Screening Results Using Otoacoustic Emissions: Based on Screening Age
The Effect of Mode of Delivery and Hospital Type on Newborn Hearing Screening Results Using Otoacoustic Emissions: Based on Screening Age: Abstract It is well known that false positive on newborn hearing screening increases cost and maternal anxiety and worry. We aimed to evaluate the influence of mode of delivery (cesarean, vaginal) and hospital type (private, public) on false positives first screening test based on screening age. Identification and control of these factors can reduce the rate of false positives. Overall, 2784 infants were evaluated by otoacoustic emissions test. ... περισσότερα »
Establishing a Temporal Bone Laboratory in Teaching Institutes to Train Future Otorhinolaryngologists and Fundamentals of Temporal Bone Laboratory: Considerations and Requirements
Establishing a Temporal Bone Laboratory in Teaching Institutes to Train Future Otorhinolaryngologists and Fundamentals of Temporal Bone Laboratory: Considerations and Requirements: AbstractTemporal bone dissection has important role in educating, and training the surgeons. Temporal bone has complicated three dimensional anatomy and it is challenging for young surgeons to understand and operate. Not knowing the anatomy may cause serious consequences to patient due to injury to vital structures. It is important to learn temporal bone harvesting techniques, preservation of specimens, ...περισσότερα »
Helicobacter pylori Activates IL-6-STAT3 Signaling in Human Gastric Cancer Cells: Potential Roles for Reactive Oxygen Species
Helicobacter pylori Activates IL-6-STAT3 Signaling in Human Gastric Cancer Cells: Potential Roles for Reactive Oxygen Species: Abstract Background Recent studies have shown that *Helicobacter pylori* (*H. pylori*) activates signal transducer and activator of transcription 3 (STAT3) that plays an important role in gastric carcinogenesis. However, the molecular mechanism underlying *H. pylori*-mediated STAT3 activation is still not fully understood. In this study, we investigated *H. pylori*-induced activation of STAT3 signaling in AGS human gastric cancer cells and the underlying me... περισσότερα »
Helicobacter pylori Activates IL-6-STAT3 Signaling in Human Gastric Cancer Cells: Potential Roles for Reactive Oxygen Species
Abstract Background Recent studies have shown that *Helicobacter pylori* (*H. pylori*) activates signal transducer and activator of transcription 3 (STAT3) that plays an important role in gastric carcinogenesis. However, the molecular mechanism underlying *H. pylori*-mediated STAT3 activation is still not fully understood. In this study, we investigated *H. pylori*-induced activation of STAT3 signaling in AGS human gastric cancer cells and the underlying mechanism. Materials and Methods AGS cells were cocultured with *H. pylori*, and STAT3 activation was assessed by Western blot...περισσότερα »
Establishing a Temporal Bone Laboratory in Teaching Institutes to Train Future Otorhinolaryngologists and Fundamentals of Temporal Bone Laboratory: Considerations and Requirements
Abstract Temporal bone dissection has important role in educating, and training the surgeons. Temporal bone has complicated three dimensional anatomy and it is challenging for young surgeons to understand and operate. Not knowing the anatomy may cause serious consequences to patient due to injury to vital structures. It is important to learn temporal bone harvesting techniques, preservation of specimens, fixation and to reduce the health hazards posed by these specimens by taking safety measures. Spending more time in temporal bone laboratory and repeated dissection of temporal bon... περισσότερα »
The Effect of Mode of Delivery and Hospital Type on Newborn Hearing Screening Results Using Otoacoustic Emissions: Based on Screening Age
Abstract It is well known that false positive on newborn hearing screening increases cost and maternal anxiety and worry. We aimed to evaluate the influence of mode of delivery (cesarean, vaginal) and hospital type (private, public) on false positives first screening test based on screening age. Identification and control of these factors can reduce the rate of false positives. Overall, 2784 infants were evaluated by otoacoustic emissions test. Hearing screening test was performed before hospital discharge. Finally, rate of the false-positive between both delivery group and hospita... περισσότερα »
Primary Tuberculous Osteomyelitis of the Mandible Mimicking a Parotid Gland Abscess
Abstract Tuberculosis has become a rare disease in the developed countries but it is still a serious problem in the developing countries. Incidence of tuberculous osteomyelitis of the jaw bones is very low. This rare incidence is the primary reason that the lesion gets misdiagnosed many times. Here we report the diagnosis, treatment and follow up of a case which is not a classical presentation of tuberculous osteomyelitis of mandible. Early diagnosis of tuberculous osteomyelitis will certainly reduce the morbidity of this disease condition. from #ORL via xlomafota13 on Inoreader ... περισσότερα »
Functions of the inner ear in psoriatic arthritis
This study aimed to investigate whether there is a negative impact as a result of psoriatic arthritis disease of the inner ear function. from #ORL via xlomafota13 on Inoreader http://ift.tt/24mKmzO via IFTTT
Senate nears final vote on Obama’s pick to lead FDA
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Clinical trials expert Robert Califf expected to win approval after months of political delay. Nature News doi: 10.1038/nature.2016.19418 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1oZF119 via IFTTT
Ein Fall für den Nerven- oder HNO-Arzt?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Patient mit akutem Schwindel Klagt ein Patient über Schwindel, was gerade bei Älteren nicht selten der Fall ist, geht es in der Praxis primär darum zu unterscheiden: Ist es ein peripher-vestibulärer oder ein zentral-vestibulärer Schwindel? from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QuZDo2 via IFTTT
Reconstruction of Extended Orbitomaxillectomy and Hemimandibulectomy Defects With Fibula Flaps and Patient-Specific Implants.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
An extended orbitomaxillectomy and hemimandibulectomy for polyostotic juvenile ossifying fibroma resection were performed with the assistance of patient-specific cutting guides. The resulting defects were reconstructed in stages. First, a patient-specific mandibular reconstruction plate was fixed to the hemimandibulectomy defect in the same operation as the resection. After margins were proven to be free of tumor […]
Application of Reverse Engineering Template for the Correction of Asymmetric Deformity of Maxillofacial Fibrous Dysplasia.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Facial asymmetry deformity is the most common symptom of patients with fibrous dysplasia. This study provides a novel method based on computed tomography scan data, mirror-imaged reverse engineering and rapid prototyping for design and manufacture of an individual template guiding accurately the extent and quantity of partial resection of hyperplastic tissues to reshape the affected […]
Autophagy protects osteoblasts from AGEs induced apoptosis through intracellular ROS
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Type II diabetic patients are susceptible to fracture; however, these patients typically have normal bone mineral density. Thus, such fractures cannot be entirely explained by advanced glycation end products (AGEs) induced osteoblast apoptosis. Autophagy is a molecular process allowing cells to degrade unnecessary or dysfunctional cellular organelles, and closely interacts with apoptosis. The aim of […]
3,5-T2 alters murine genes relevant for xenobiotic, steroid and thyroid hormone metabolism
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
The endogenous thyroid hormone metabolite 3,5-diiodo-L-thyronine (3,5-T2) acts as a metabolically active substance affecting whole body energy metabolism and hepatic lipid handling in a desirable manner. Considering possible adverse effects regarding thyromimetic action of 3,5-T2 treatment in rodents, the current literature remains largely controversial. To obtain further insight into molecular mechanisms and to identify novel […]
The role of diffusion-weighted magnetic resonance imaging in assessing residual/recurrent cholesteatoma after canal wall down mastoidectomy
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Parotitis and Sialendoscopy of the Parotid Gland
[image: gr1.sml] Nonneoplastic disorders of the salivary glands involve inflammatory processes. These disorders have been managed conservatively with antibiotics, warm compresses, massage, sialogogues, and adequate hydration. Up to 40% of patients may have an inadequate response or persistent symptoms. When conservative techniques fail, the next step is operative intervention. Sialendoscopy offers a minimally invasive option for the diagnosis and management of chronic inflammatory disorders of the salivary glands and offers the option of gland and function preservation. In this ar...περισσότερα »
Evaluation of The CDC Recommendations for HCV Testing in an Urban Emergency Department
We assessed the burden of undocumented HCV infection in emergency department (ED) patients prior to implementation of an ED-based HCV testing program. Our data suggest the need to consider expanding the current CDC birth-cohort based testing in urban healthcare settings. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1oEgA9u via IFTTT
Prevalence of Diagnosed and Undiagnosed Hepatitis C in a Midwestern Urban Emergency Department
The prevalence of HCV is remarkably high in emergency department populations, even in a region of the Midwest not characterized by high HIV prevalence. In this setting, many patients will be missed, if using only the birth cohort screening approach. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/20RXNU1 via IFTTT
Effect of previous year vaccination on the efficacy, immunogenicity, and safety of high-dose inactivated influenza vaccine in older adults
High-dose inactivated split-virus influenza vaccine showed higher immunogenicity and relative efficacy compared to standard-dose inactivated split-virus influenza vaccine, irrespective of type of vaccine used the preceding year. The safety profile was also unaffected by previous year vaccine. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1oEgz5H via IFTTT
Reply to Deeny et al.
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More research is needed to quantify risks, benefits and cost-effectiveness of universal mupirocin usage
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Distinguishing Postobstructive Lung Infection From Community-Acquired Pneumonia
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A Phase 3, Double-Blind, Randomized Study of Arterolane Maleate-Piperaquine Phosphate vs Artemether-Lumefantrine for Falciparum Malaria in Adolescent and Adult Patients in Asia and Africa
Arterolane is a rapid-acting, synthetic trioxolane with activity against all erythrocytic stages of *Plasmodium falciparum*. The advantages of arterolane maleate–piperaquine phosphate are once-daily dose, high clinical and parasitological response rates, and rapid parasite clearance. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1oEgz5C via IFTTT
Recent Thymus Emigrant CD4+ T Cells Predict HIV Disease Progression in Patients With Perinatally Acquired HIV
Recent thymic emigrant CD4+ T cells in perinatally human immunodeficiency virus –infected patients predict disease progression as reflected by CD4 count change and/or viral load change. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1Qdqw3O via IFTTT
Martins on Lenvatinib’s Significance in Differentiated Thyroid Cancer – OncLive
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
OncLive Martins on Lenvatinib’s Significance in Differentiated Thyroid Cancer OncLive Martins: The lenvatinib papers show something very important—that there is a lack of cross-resistance between these tyrosine kinase inhibitors for thyroid cancer. In one of the lenvatinib papers, the response rate in patients who had received a prior … and more » from #AlexandrosSfakianakis via […]
Use of Positron Emission Tomography to Detect Recurrence and Associations With Survival in Patients With Lung and Esophageal Cancers
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: Positron emission tomography (PET) scans are often used in cancer patients for staging, restaging, and monitoring for treatment response. These scans are also often used to detect recurrence in asymptomatic patients, despite a lack of evidence demonstrating improved survival. We sought to evaluate utilization of PET for this purpose and relationships with survival for […]
Study Shows Likely Overuse of PET Scans to Detect Recurrence in Lung & Esophageal Cancers
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Fluorescence optical imaging in anticancer drug delivery
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 28 March 2016 Source:Journal of Controlled Release, Volume 226 Author(s): Tomáš Etrych, Henrike Lucas, Olga Janoušková, Petr Chytil, Thomas Mueller, Karsten Mäder In the past several decades, nanosized drug delivery systems with various targeting functions and controlled drug release capabilities inside targeted tissues or cells have been intensively studied. Understanding their pharmacokinetic properties […]
Assessing biocompatibility of graphene oxide-based nanocarriers: A review
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 28 March 2016 Source:Journal of Controlled Release, Volume 226 Author(s): Siaw Fui Kiew, Lik Voon Kiew, Hong Boon Lee, Toyoko Imae, Lip Yong Chung Graphene oxide (GO)-based nanocarriers have been frequently studied due to their high drug loading capacity. However, the unsatisfactory biocompatibility of these GO-based nanocarriers hampers their use in clinical settings. […]
A magnetic vehicle realized tumor cell-targeted radiotherapy using low-dose radiation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 28 March 2016 Source:Journal of Controlled Release, Volume 226 Author(s): Hsiao-Ping Chen, Fu-I Tung, Ming-Hong Chen, Tse-Ying Liu Radiotherapy, a common cancer treatment, often adversely affects the surrounding healthy tissue and/or cells. Some tumor tissue-focused radiation therapies have been developed to lower radiation-induced lesion formation; however, achieving tumor cell-targeted radiotherapy (i.e., precisely focusing […]
Stepwise pH-responsive nanoparticles containing charge-reversible pullulan-based shells and poly(β-amino ester)/poly(lactic-co-glycolic acid) cores as carriers of anticancer drugs for combination therapy on hepatocellular carcinoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 28 March 2016 Source:Journal of Controlled Release, Volume 226 Author(s): Cong Zhang, Tong An, Dan Wang, Guoyun Wan, Mingming Zhang, Hemei Wang, Sipei Zhang, Rongshan Li, Xiaoying Yang, Yinsong Wang Stepwise pH-responsive nanoparticle system containing charge reversible pullulan-based (CAPL) shell and poly(β-amino ester) (PBAE)/poly(lactic-co-glycolic acid) (PLAG) core is designed to be used as […]
Self-assembled ternary complexes stabilized with hyaluronic acid-green tea catechin conjugates for targeted gene delivery
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 28 March 2016 Source:Journal of Controlled Release, Volume 226 Author(s): Kun Liang, Ki Hyun Bae, Fan Lee, Keming Xu, Joo Eun Chung, Shu Jun Gao, Motoichi Kurisawa Nanosized polyelectrolyte complexes are attractive delivery vehicles for the transfer of therapeutic genes to diseased cells. Here we report the application of self-assembled ternary complexes constructed […]
Molecular engineering of high affinity single-chain antibody fragment for endothelial targeting of proteins and nanocarriers in rodents and humans
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 28 March 2016 Source:Journal of Controlled Release, Volume 226 Author(s): Colin F. Greineder, Elizabeth D. Hood, Anning Yao, Makan Khoshnejad, Jake S. Brenner, Ian H. Johnston, Mortimer Poncz, Claudia Gottstein, Vladimir R. Muzykantov Endothelial cells (EC) represent an important target for pharmacologic intervention, given their central role in a wide variety of human […]
Transcending epithelial and intracellular biological barriers; a prototype DNA delivery device
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 28 March 2016 Source:Journal of Controlled Release, Volume 226 Author(s): Joanne McCaffrey, Cian M. McCrudden, Ahlam A. Ali, Ashley S. Massey, John W. McBride, Maelíosa T.C. McCrudden, Eva M. Vicente-Perez, Jonathan A. Coulter, Tracy Robson, Ryan F. Donnelly, Helen O. McCarthy Microneedle technology provides the opportunity for the delivery of DNA therapeutics by […]
The placebo effect in thyroid cancer: a meta-analysis
Context The natural history of advanced thyroid malignancies is largely unknown. The outcome of patients included in the placebo arm of clinical trials could be reflective of their therapy-free evolution. Objective To analyze the response rate, symptoms and adverse effects of locally advanced or metastatic differentiated (DTC) and medullary thyroid cancer (MTC) in patients treated with placebo in clinical trials. Design PubMed (MEDLINE) and SCOPUS databases were searched through September 2015 to identify high-quality randomized controlled clinical trials. We included studies ... περισσότερα »
Polycystic ovary syndrome is associated with increased osteopontin levels
Objective Osteopontin (OPN) is a multi-functional secreted glycoprotein that plays a crucial role in glucose metabolism and inflammatory process. Growing evidence suggests that there is a link between OPN and ovarian function. However, no such link has yet been found for OPN in polycystic ovary syndrome (PCOS). Our aim was to ascertain whether circulating OPN levels are altered in women with PCOS and to determine whether OPN levels differ between the follicular phase and mid-cycle of the menstrual cycle in eumenorrheic women. Design and methods In total, 150 women with PCOS and...περισσότερα »
Adaptation to acute coronary syndrome-induced stress with lowering of testosterone: a possible survival factor
Objective The objective of this study was to explore whether circulating testosterone (T) concentration is associated with the occurrence and risk for acute coronary syndromes (ACS). Method This case–control study included male patients with acute myocardial infarction (AMI) (*n*=174) or unstable angina pectoris (UAP) (*n*=90) and healthy controls (*n*=238). Patients gave serum samples during the acute ( *n*=264) and recovery (*n*=132) phases after a median of 10.5 months after the incident event. Secondary events (ACS or cardiovascular death) were registered during the followin... περισσότερα »
Association of antiepileptic drug usage, trace elements and thyroid hormone status
Background Levels of thyroid hormone (TH) and trace elements (copper (Cu) and selenium (Se)) are important for development and function of the brain. Anti-epileptic drugs (AEDs) can influence serum TH and trace element levels. As the relationship between AEDs, THs, and trace elements has not yet been studied directly, we explored these interactions. Method In total 898 participants, from the Thyroid Origin of Psychomotor Retardation study designed to investigate thyroid parameters in subjects with intellectual disability (ID), had data available on serum Se, Cu, thyroid stimula... περισσότερα »
Leptin secretory dynamics and associated disordered eating psychopathology across the weight spectrum
Objective Leptin secretory dynamics across the weight spectrum and their relationship with disordered eating psychopathology have not been studied. Our objective was to compare leptin secretory dynamics in 13 anorexia nervosa (AN), 12 overweight/obese (OB) and 12 normal-weight women using deconvolution analysis. Methods In this cross-sectional study conducted at a tertiary referral center, serum leptin levels were obtained every 20 min from 2000 to 0800 h. Dual energy X-ray absorptiometry was used to measure percent body fat. Disordered eating psychopathology was assessed by th... περισσότερα »
Adiponectin, markers of subclinical inflammation and nerve conduction in individuals with recently diagnosed type 1 and type 2 diabetes
Objective Subclinical inflammation has been implicated in the development of diabetic sensorimotor polyneuropathy (DSPN), but studies using electrophysiological assessment as outcomes are scarce. Therefore, we aimed to investigate associations of biomarkers reflecting different aspects of subclinical inflammation with motor and sensory nerve conduction velocity (NCV) in individuals with diabetes. Design and methods Motor and sensory NCV was assessed in individuals with recently diagnosed type 2 (*n*=352) or type 1 diabetes (*n*=161) from the baseline cohort of the observational...περισσότερα »
Randomised clinical trial: alginate (Gaviscon Advance) vs. placebo as add-on therapy in reflux patients with inadequate response to a once daily proton pump inhibitor
Summary Background Many reflux patients remain symptomatic on a standard dose of proton pump inhibitor (PPI). Alginates decrease the number of reflux events by forming a raft on top of the stomach content and thus offer a supplemental mechanism of action to acid suppression. Aim To assess the efficacy of an alginate (Gaviscon Advance, Reckitt Benckiser, Slough, UK) on reflux symptoms in patients with persistent symptoms despite once daily PPI. Methods This was a multicentre, randomised, placebo-controlled, 7-day double-blind trial preceded by a 7-day run-in period. Reflux sympt... περισσότερα »
Study Shows Likely Overuse of PET Scans to Detect Recurrence in Lung & Esophageal Cancers
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Natural Killer Cell-Based Immunotherapy in Acute Myeloid Leukemia: Lessons for the Future
The article by Curti and colleagues highlights the potential of NK cell-based adoptive cellular immunotherapy in oncology, currently boosted by advances in the knowledge on NK cell biology and in their ex-vivo GMP manipulation. Several issues deserve attention to fully achieve the translation of these advances to the clinic. from Cancer via ola Kala on Inoreader http://ift.tt/1L7RRnT via IFTTT
Not flavone-8-acetic acid (FAA) but its murine metabolite 6-OH-FAA exhibits remarkable antivascular activities in vitro.
Flavone-8-acetic acid (FAA) has been proved to be a potent vascular-disrupting agent in mice. Unfortunately, FAA did not produce any anticancer activity in clinical trials. Previously, we had reported that FAA is metabolized by mouse microsomes into six metabolites, whereas it was poorly metabolized by human microsomes, with fewer metabolites formed in lesser amounts. Especially, 6-OH-FAA was not formed by human microsomes. In this work, two major available metabolites, 4'-OH-FAA and 6-OH-FAA, were tested and compared with the parent compound FAA for their potential antivascular act...περισσότερα »
Cardiovascular adverse effects of targeted antiangiogenic drugs: mechanisms and management
Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/1Qdrb5o via IFTTT
A Rare Case of Multilocular Thymic Cyst with Follicular Lymphoid Hyperplasia: Radiologic and Histopathologic Features
Abstract Multilocular thymic cysts are rare and acquired lesions induced by an inflammatory arising within the thymus. We report a rare case of multilocular thymic cyst with follicular lymphoid hyperplasia in a 59-year-old female. Chest CT and MRI revealed a large multilocular cystic mass, which contains thick septa and nodules in the thymus. F-18 FDG PET/CT showed almost no FDG uptake of the multilocular cystic mass but moderate FDG uptake of the solid nodules. Extended total thymectomy was performed. Histopathological findings revealed follicular lymphoid hyperplasia of thymic t... περισσότερα »
Indeterminate Findings on Oncologic PET/CT: What Difference Does PET/MRI Make?
Abstract Background Positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) has become the standard of care for the initial staging and subsequent treatment response assessment of many different malignancies. Despite this success, PET/CT is often supplemented by MRI to improve assessment of local tumor invasion and to facilitate detection of lesions in organs with high background FDG uptake. Consequently, PET/MRI has the potential to expand the clinical value of PET examinations by increasing reader certainty and reducing the need for su...περισσότερα »
Instrumentation for Time-of-Flight Positron Emission Tomography
Abstract Positron emission tomography (PET) is a molecular imaging modality that provides information at the molecular level. This system is composed of radiation detectors to detect incoming coincident annihilation gamma photons emitted from the radiopharmaceutical injected into a patient's body and uses these data to reconstruct images. A major trend in PET instrumentation is the development of time-of-flight positron emission tomography (ToF-PET). In ToF-PET, the time information (the instant the radiation is detected) is incorporated for image reconstruction. Therefore, precis... περισσότερα »
Tumor volume is a better predictor of post-operative wound complications compared to tumor size in soft tissue sarcomas of the proximal lower extremity
Abstract Background Wide local excision with or without radiation therapy (RT) and chemotherapy is widely accepted as appropriate management for soft tissue sarcomas (STS) of the extremity. Although survival and local control rates are comparable to amputation, post-operative wound complications (WC) following limb salvage can result in significant morbidity for the patient. Certain risk factors such as location, pre-operative RT, and age have been shown to increase the risk of WCs. Somewhat surprisingly, size has not consistently been shown to impact WC rates. The goal of this stu...περισσότερα »
Gene Fusion May Drive Rare Childhood Brain Tumor
Researchers have identified a genetic rearrangement that may drive the development of a rare benign brain tumor in children. The rearrangement, which causes parts of two genes to fuse, may spur the growth of tumors through three distinct biological mechanisms simultaneously, the researchers found. The study focused on angiocentric gliomas, a rare subtype of low-grade pediatric tumors that was first described less than a decade ago. Fewer than 30 cases have been reported in the scientific literature. Based on their findings, the study authors propose that angiocentric gliomas shoul... περισσότερα »
A phase I trial of panobinostat and epirubicin in solid tumors with a dose expansion in patients with sarcoma
This phase I study evaluated combined panobinostat and epirubicin in patients with advanced solid tumors, establishing a MTD, and demonstrating a correlation between neutropenia, PBMC histone acetylation and clinical benefit. In a sarcoma expansion cohort, more than half of patients, having previously failed anthracycline therapy, benefited, suggesting HDAC inhibition reverses resistance. from Cancer via ola Kala on Inoreader http://ift.tt/1oytFAH via IFTTT
On the tumor risk from dental diagnostic X-ray exposure
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A phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma
Background The combination of galunisertib, a transforming growth factor (TGF)-β receptor (R)1 kinase inhibitor, and lomustine was found to have antitumor activity in murine models of glioblastoma. Methods Galunisertib (300 mg/day) was given orally 14 days on/14 days off (intermittent dosing). Lomustine was given as approved. Patients were randomized in a 2:1:1 ratio to galunisertib + lomustine, galunisertib monotherapy, or placebo + lomustine. The primary objective was overall survival (OS); secondary objectives were safety, pharmacokinetics (PKs), and antitumor activity. Resu... περισσότερα »
A randomized, placebo-controlled pilot trial of armodafinil for fatigue in patients with gliomas undergoing radiotherapy
Background Fatigue is common among glioma patients undergoing radiotherapy (RT) and impacts quality of life (QOL). We evaluated whether armodafinil, a wakefulness-promoting medication, improves fatigue in glioma patients undergoing RT. Methods Eligibility criteria included age ≥18 years, Karnofsky performance status ≥60, and grade 2–4 glioma undergoing RT to a total dose of 50–60 Gy. Patients were randomized 1:1 to armodafinil or placebo for 8 weeks beginning within 10 days of starting RT. Fatigue and QOL were assessed at baseline, day 22, day 43, and day 56 with the Functional... περισσότερα »
Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas
from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1OrrG6g via IFTTT
A phase I trial of panobinostat and epirubicin in solid tumors with a dose expansion in patients with sarcoma
This phase I study evaluated combined panobinostat and epirubicin in patients with advanced solid tumors, establishing a MTD, and demonstrating a correlation between neutropenia, PBMC histone acetylation and clinical benefit. In a sarcoma expansion cohort, more than half of patients, having previously failed anthracycline therapy, benefited, suggesting HDAC inhibition reverses resistance. from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1oytFAH via IFTTT
On the tumor risk from dental diagnostic X-ray exposure
from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1L7Bo2Y via IFTTT
Comparison of prognostic and predictive impact of genomic or central grade and immunohistochemical subtypes or IHC4 in HR+/HER2- early breast cancer: WSG-AGO EC-Doc Trial
Central grade and luminal-A-like subtype were significant predictors of outcome if genomic grade as dichotomous factor (GG1/EQ vs. GG3) was included into the multivariate analysis in breast cancer patients treated by EC-Doc or FEC within the EC-Doc trial. Only continuous GGI but not IHC4 was strong prognostic factor beyond all other factorsin HR+/HER2- breast cancer even if central grade was available. from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1oytDsD via IFTTT
Breast Cancer Incidence and Mortality: Trends over Forty Years among Women in Shanghai, China
With 40-years of cancer data from the oldest population-based cancer registry in China, this study evaluate secular time trends in breast cancer incidence and mortality in an urban Chinese population. Our results show a tremendous increase in incidence and a slight increase in mortality with significant age, cohort and period effects for breast cancer among women in urban Shanghai. from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1L7Bo2W via IFTTT
Large-Scale Prospective Pharmacogenomics Study of Oxaliplatin-Induced Neuropathy in Colon Cancer Patients enrolled in the JFMC41-1001-C2 (JOIN Trial)
Our large-scale and prospective pharmacogenomics study of Japanese patients receiving protocol treatment of adjuvant mFOLFOX6 could not verify a role for any of the 12 SNP markers reported as being significantly associated with oxaliplatin-induced peripheral sensory neuropathy. from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1oytFAD via IFTTT
A phase II trial of abiraterone acetate plus prednisone in patients with triple-negative androgen receptor positive locally advanced or metastatic breast cancer (UCBG 12-1)
Treatment with abirterone acetate, in combination with prednisone, is beneficial for some patients with molecular apocrine tumours. from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1L7BpEd via IFTTT
A Phase 1 Dose-Escalation Study of Apatorsen (OGX-427), an Antisense Inhibitor Targeting Heat Shock Protein 27 (Hsp27), in Patients with Castration Resistant Prostate Cancer and Other Advanced Cancers
Apatorsen is an antisense inhibitor of heat shock protein 27 (Hsp27), a chaperone protein that regulates cell survival via androgen receptor and other signaling pathways. A Phase 1 study was conducted in patients with CRPC and other cancers known to overexpress Hsp27. Apatorsen had an acceptable safety profile and a MTD was not defined. Clinical activity at doses ≥400 mg was suggested by effects on stable measurable disease, declines in PSA, other tumor markers, and CTCs. from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1oytFAB via IFTTT
Role of major resection in pulmonary metastasectomy for colorectal cancer in the Spanish Prospective Multicenter Study (GECMP-CCR)
Patients with pulmonary metastases from colorectal cancer (CRC) may benefit from aggressive surgical therapy. The objective of this study was to determine the role of major anatomic resection for pulmonary metastasectomy to improve survival as compared to limited pulmonary resection. Major anatomic resection with lymphadenectomy for pulmonary metastasectomy can be considered in selected CRC patient with sufficient functional reserve to improve the DSS and DFS. Further prospective randomized studies are needed to confirm the present results. from #Oncology via alexandrossfakianaki... περισσότερα »
VEGF-C Is a Thyroid Marker of Malignancy Superior to VEGF-A in the Differential Diagnostics of Thyroid Lesions
by Kosma Woliński, Adam Stangierski, Ewelina Szczepanek-Parulska, Edyta Gurgul, Bartłomiej Budny, Elzbieta Wrotkowska, Maciej Biczysko, Marek Ruchala Introduction Thyroid nodular goiter is one of the most common medical conditions affecting even over a half of adult population. The risk of malignancy is rather small but noticeable–estimated by numerous studies to be about 3–10%. The definite differentiation between benign and malignant ones is a vital issue in endocrine practice. The aim of the current study was to assess the expression of vascular endothelial growth factor A (VE...περισσότερα »
Different responses of mouse islets and MIN6 pseudo-islets to metabolic stimulation: a note of caution
Abstract MIN6 cells and MIN6 pseudo-islets are popular surrogates for the use of primary beta cells and islets. Even though it is generally agreed that the stimulus-secretion coupling may deviate from that of beta cells or islets, direct comparisons are rare. The present side-by-side comparison of insulin secretion, cytosolic Ca2+ concentration ([Ca2+]i ) and oxygen… Continue reading Different responses of mouse islets and MIN6 pseudo-islets to metabolic stimulation: a note of caution
Obesity prevention at the point of purchase
Summary The point of purchase is when people may make poor and impulsive decisions about what and how much to buy and consume. Because point of purchase strategies frequently work through non-cognitive processes, people are often unable to recognize and resist them. Because people lack insight into how marketing practices interfere with their ability to… Continue reading Obesity prevention at the point of purchase
Is there any association between primary hyperparathyroidism and ocular changes, such as central corneal thickness, retinal thickness, and intraocular pressure?
Abstract Ocular changes are commonly encountered in various endocrine disorders. However, only a few studies have reported ocular changes in patients with primary hyperparathyroidism (PHPT). Here, we examined the central corneal thickness (CCT), retinal thickness (RT), and intraocular pressure (IOP), and their relationships with serum intact parathyroid hormone (iPTH), calcium (Ca), and phosphorus (P) levels… Continue reading Is there any association between primary hyperparathyroidism and ocular changes, such as central corneal thickness, retinal thickness, and intraocular pressure?
Management of Cushing’s disease: a single-center experience
Abstract The purpose of this study was to review therapeutic outcomes and comorbidities of patients with Cushing’s disease (CD) in a single center. We conducted a retrospective study of 33 patients with CD undergoing transsphenoidal surgery from January 2007 to February 2014 (27 females and 6 males, median age 38 years, range 18–71 years). The… Continue reading Management of Cushing’s disease: a single-center experience
MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus
Subjects with type 1 diabetes mellitus (T1DM) have decreased bone mineral density and an up to sixfold increase in fracture risk. Yet bone fragility is not commonly regarded as another unique complication of diabetes. Both animals with experimentally induced insulin deficiency syndromes and patients with T1DM have impaired osteoblastic bone formation, with or without increased… Continue reading MECHANISMS IN ENDOCRINOLOGY: Mechanisms and evaluation of bone fragility in type 1 diabetes mellitus
Impact of pre-treatment with somatostatin analogs on surgical management of acromegalic patients referred to a single center
Abstract First-line treatment of patients with growth hormone secreting adenomas is surgical resection. Disease control can be obtained by surgery (one or multiple steps), in case followed by medical treatment or adjuvant radiation therapy (radiosurgery or radiotherapy). The impact of pre-surgical treatment with somatostatin analogs (SSAs) on surgical outcome is still controversial. The aim of… Continue reading Impact of pre-treatment with somatostatin analogs on surgical management of acromegalic patients referred to a single center
MECHANISMS IN ENDOCRINOLOGY: Novel genetic causes of short stature
The fast technological development, particularly single nucleotide polymorphism array, array-comparative genomic hybridization, and whole exome sequencing, has led to the discovery of many novel genetic causes of growth failure. In this review we discuss a selection of these, according to a diagnostic classification centred on the epiphyseal growth plate. We successively discuss disorders in hormone… Continue reading MECHANISMS IN ENDOCRINOLOGY: Novel genetic causes of short stature
ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome
Genetic predictors of outcome are reviewed in the context of a disease – cancer – that can be (too) simplistically described as a ‘successful, invasive clone of our own tissues’. Context has many faces that determine a thyroid cancer patient’s outcome beyond the influence of genetic markers. There is also plenty of evidence on the… Continue reading ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome
Very low frequency of germline GPR101 genetic variation and no biallelic defects with AIP in a large cohort of patients with sporadic pituitary adenomas
Context Recently, germline and somatic GPR101 p.(E308D) mutation was found in patients with isolated acromegaly. It is not known whether GPR101 point mutations are associated with other histological types of pituitary adenoma. Objective We sought germline GPR101 mutations in patients with sporadic pituitary adenomas, and compared the phenotypes of GPR101 mutation carriers and AIP mutation… Continue reading Very low frequency of germline GPR101 genetic variation and no biallelic defects with AIP in a large cohort of patients with sporadic pituitary adenomas
Effects of vitamin D binding protein phenotypes and vitamin D supplementation on serum total 25(OH)D and directly measured free 25(OH)D
Objective To determine the relationship between serum total 25-hydroxyvitamin D (25(OH)D), directly measured free 25(OH)D and calculated free 25(OH)D with regard to vitamin D-binding protein (DBP) phenotypes, sex, BMI, age and season, and their interrelationship to vitamin D supplementation. Design, patients and interventions A randomized controlled trial with 20 000 IU of vitamin D3 per… Continue reading Effects of vitamin D binding protein phenotypes and vitamin D supplementation on serum total 25(OH)D and directly measured free 25(OH)D
Very low frequency of germline GPR101 genetic variation and no biallelic defects with AIP in a large cohort of patients with sporadic pituitary adenomas
Context Recently, germline and somatic *GPR101* p.(E308D) mutation was found in patients with isolated acromegaly. It is not known whether *GPR101* point mutations are associated with other histological types of pituitary adenoma. Objective We sought germline *GPR101* mutations in patients with sporadic pituitary adenomas, and compared the phenotypes of *GPR101* mutation carriers and *AIP* mutation carriers. Design An observational cohort study performed between 2007 and 2014 in a single referral center. Participants This prospective study involved 766 unselected patients (41... περισσότερα »
Effects of vitamin D binding protein phenotypes and vitamin D supplementation on serum total 25(OH)D and directly measured free 25(OH)D
Objective To determine the relationship between serum total 25-hydroxyvitamin D (25(OH)D), directly measured free 25(OH)D and calculated free 25(OH)D with regard to vitamin D-binding protein (DBP) phenotypes, sex, BMI, age and season, and their interrelationship to vitamin D supplementation. Design, patients and interventions A randomized controlled trial with 20 000 IU of vitamin D3 per week or placebo for 12 months was designed. A total of 472 subjects, 236 in each of the intervention groups, were included in the analyses. Main outcome measures Baseline serum concentrations a...περισσότερα »
Natural course of congenital hypothyroidism by dual oxidase 2 mutations from the neonatal period through puberty
Aim We previously reported that biallelic mutations in dual oxidase 2 (*DUOX2*) cause transient hypothyroidism. Since then, many cases with *DUOX2* mutations have been reported. However, the clinical features and prognosis of individuals with *DUOX2* defects have not been clarified. Objective We investigated the prognosis of patients with congenital hypothyroidism (CH) due to *DUOX2* mutations. Patients Twenty-five patients were identified by a neonatal screening program and included seven familial cases. Their serum TSH values ranged from 18.9 to 734.6 mU/l. Twenty-two of the...περισσότερα »
Natural course of congenital hypothyroidism by dual oxidase 2 mutations from the neonatal period through puberty
Aim We previously reported that biallelic mutations in dual oxidase 2 (*DUOX2*) cause transient hypothyroidism. Since then, many cases with *DUOX2* mutations have been reported. However, the clinical features and prognosis of individuals with *DUOX2* defects have not been clarified. Objective We investigated the prognosis of patients with congenital hypothyroidism (CH) due to *DUOX2* mutations. Patients Twenty-five patients were identified by a neonatal screening program and included seven familial cases. Their serum TSH values ranged from 18.9 to 734.6 mU/l. Twenty-two of the...περισσότερα »
Association of antiepileptic drug usage, trace elements and thyroid hormone status
Background Levels of thyroid hormone (TH) and trace elements (copper (Cu) and selenium (Se)) are important for development and function of the brain. Anti-epileptic drugs (AEDs) can influence serum TH and trace element levels. As the relationship between AEDs, THs, and trace elements has not yet been studied directly, we explored these interactions. Method In total 898 participants, from the Thyroid Origin of Psychomotor Retardation study designed to investigate thyroid parameters in subjects with intellectual disability (ID), had data available on serum Se, Cu, thyroid stimula... περισσότερα »
Trans-Sacral Epiduroscopic Laser Decompression for Symptomatic Lumbar Disc Herniation: A Preliminary Case Series
Photomedicine and Laser Surgery , Vol. 0, No. 0. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1oZvAyH via IFTTT
Shear Bond Strength of Intraoral Laser Welding and its Effect on Intrapulpal Temperature Rise in Primary Teeth: An in Vitro Study
Photomedicine and Laser Surgery , Vol. 0, No. 0. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1QuSaFu via IFTTT
Trans-Sacral Epiduroscopic Laser Decompression for Symptomatic Lumbar Disc Herniation: A Preliminary Case Series
Photomedicine and Laser Surgery , Vol. 0, No. 0. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1oZvAin via IFTTT
Shear Bond Strength of Intraoral Laser Welding and its Effect on Intrapulpal Temperature Rise in Primary Teeth: An in Vitro Study
Photomedicine and Laser Surgery , Vol. 0, No. 0. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1OrAFVg via IFTTT
High-Efficient Transfection of Human Embryonic Stem Cells by Single-Cell Plating and Starvation
Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/1SP6Y8g via IFTTT
High-Efficient Transfection of Human Embryonic Stem Cells by Single-Cell Plating and Starvation
Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/1SP6Y8g via IFTTT
The placebo effect in thyroid cancer: a meta-analysis
Context The natural history of advanced thyroid malignancies is largely unknown. The outcome of patients included in the placebo arm of clinical trials could be reflective of their therapy-free evolution. Objective To analyze the response rate, symptoms and adverse effects of locally advanced or metastatic differentiated (DTC) and medullary thyroid cancer (MTC) in patients treated with placebo in clinical trials. Design PubMed (MEDLINE) and SCOPUS databases were searched through September 2015 to identify high-quality randomized controlled clinical trials. We included studies ... περισσότερα »
Quality of life, clinical outcomes and safety of early prophylactic levothyroxine administration in patients with Graves' hyperthyroidism undergoing radioiodine therapy: a randomized controlled study
Objective While radioiodine therapy is commonly used for treating Graves' disease, a prolonged and clinical hypothyroidism may result in disabling symptoms leading to deterioration of quality of life (QoL) of patients. Introducing levothyroxine (LT4) treatment in the early post-therapeutic period may be an interesting approach to limit this phenomenon. Methods A multicenter, prospective, open-label randomized controlled trial enrolled 94 patients with Graves' hyperthyroidism randomly assigned to the experimental group (*n*=46) (group A: early prophylactic LT4 treatment) or the ... περισσότερα »
