Dr. Ferrate, MD Supports ASBA For Involving Industry Leading Procedures And Techniques In Protocols
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
It is no secret that dental sleep medicine and sleep apnea awareness have taken an enormous leap in recent years-with the largest sleep apnea awareness event planned by David Gergen and held in Phoenix, AZ. The event that was hosted by Pro Player Health Alliance, Arizona Cardinals and the American Sleep and Breathing Academy (ASBA) saw over 3,000 attendees. As the industry continues to grow through research and technological advances, pioneers of sleep medicine continue to uncover innovative breakthroughs that give practitioners the upper hand in their battle against the sleeping dis... περισσότερα »
Tracheostomy decannulation at the Royal Hospital for Sick Children in Glasgow: predictors of success and failure
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Tracheostomy techniques, indications and care are extensively covered in the literature. However, little is written about the process of removing the tracheostomy tube. At the Royal Hospital for Sick Children in Glasgow we use a stepwise ward-based protocol for safe tracheostomy decannulation. Our aim therefore was to review all the paediatric tracheostomy decannulations that we attempted over the last 3 years to evaluate our protocol, to determine our success rate and to see whether any modifications to the protocol are required. http://ift.tt/29AqW3d
Assessing the Reliability and Use of the Expository Scoring Scheme as a Measure of Developmental Change in Monolingual English and Bilingual French/English Children
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Purpose The Expository Scoring Scheme (ESS) is designed to analyze the macrostructure of descriptions of a favorite game or sport. This pilot study examined inter- and intrarater reliability of the ESS and use of the scale to capture developmental change in elementary school children. Method Twenty-four children in 2 language groups (monolingual English and bilingual French/English) and 2 age groups (7–8 years, 11–12 years) participated (6 in each subgroup). Participants orally explained how to play their favorite game or sport in English. Expository discourse samples were rated for... περισσότερα »
Dysphonie und Dysphagie durch einen gestielten Hypopharynx-Polypen
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Laryngo-Rhino-Otol DOI: 10.1055/s-0042-109614 © Georg Thieme Verlag KG Stuttgart · New York Article in Thieme eJournals: Table of contents | Full text http://ift.tt/29BXqt9
ASBA To Head A Delegation To A Caucus Committee of Congress September 2016 – Huffington Post
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
A special presentation to a Caucus Committee of Congress is scheduled for September 27, 2016. The American Sleep and Breathing Academy (ASBA) will head a delegation to this committee to introduce micro recorder compliance in oral appliances, the evolution of oral devices including the government-chosen mechanism for treating OSA. David Gergen will provide an overview of theProPlayer program along with testimonials from NFL greats Eric Dickerson, Marcus Allen, Roy Green, and others who will share personal experiences of being treated for sleep apnea. Read more on the Huffington Pos... περισσότερα »
Risk Factors for the Incidence of Perceived Voice Disorders in Elementary and Middle School Teachers
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
This study aimed to identify risk factors for the incidence of perceived voice disorders in teachers, specifically related to the influence of common mental disorders. http://ift.tt/29HaPSq
Objective Evaluation of Presbyphonia: Spectroacoustic Study on 142 Patients with Praat
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Presbyphonia is the sequence of physiological events related to the process of senility of the vocal folds. The aim of our analysis was to provide deeper knowledge of presbyphonia, raising awareness of this condition as well as giving basic suggestions on how to treat related vocal alterations. http://ift.tt/29GJaFe
Validation of the Acoustic Voice Quality Index in the Lithuanian Language
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
The aim of the present study was to validate the Acoustic Voice Quality Index in Lithuanian language (AVQI-LT) and investigate the feasibility and robustness of its diagnostic accuracy, differentiating normal and dysphonic voice. http://ift.tt/29HbfbF
Reliability and Validity of the Turkish Version of the Voice-Related Quality of Life Measure
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
This study aims to test the validity and reliability of the Turkish version of the Voice-Related Quality of Life (V-RQOL) questionnaire. http://ift.tt/29TCelg
Mandibular reconstruction with the vascularized fibula flap: comparison of virtual planning surgery and conventional surgery
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
This study evaluated the accuracy of mandibular reconstruction and assessed clinical outcomes in both virtual planning and conventional surgery patients. ProPlan CMF surgical planning software was used preoperatively in the virtual planning group. In the virtual planning group, fibula flaps were harvested and osteotomized, and the mandibles were resected and reconstructed assisted by the prefabricated cutting guides and templates. The main outcome measures included the operative time, postoperative computed tomography (CT) scans, facial appearance, and occlusal function. http://if... περισσότερα »
p38 MAPK mediates epithelial-mesenchymal transition by regulating p38IP and Snail in head and neck squamous cell carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Patients with HNSCC are at considerable risk of mortality, with more than 300,000 deaths worldwide attributable to the disease per year [1]. The major causes of HNSCC-related deaths are cervical node and distant metastasis [2]. Delineation of the mechanisms involved in the metastastic behavior of HNSCC is of the utmost importance for effective management of this disease. http://ift.tt/29GDpYk
Does Anyone In Your Family Have Obstructive Sleep Apnea?
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
http://ift.tt/29MqH85
Sleep and Weight among Our Veterans
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
http://ift.tt/29FEGsx
Decreased Symptoms without Augmented Skin Blood Flow in Subjects with RLS/WED after Vibration Treatment
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Study Objectives: Vascular disturbances leading to tissue hypoxia have been named as a possible cause for RLS/WED. Vibration to the whole body (WBV) in subjects with RLS/WED results in increased skin blood flow (SBF). The aims of this investigation were to (1) determine if a two-week treatment with WBV will decrease symptoms associated with RLS/WED and, (2) if so, determine if the mechanism for improvement in symptoms is related to an increase in SBF, as measured in flux. Methods: Eleven subjects with RLS/WED underwent 2 weeks of 14-minute intermittent WBV and a 2-week sham trea... περισσότερα »
Predicting Obstructive Sleep Apnea with Periodic Snoring Sound Recorded at Home
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Study Objectives: The cost-effectiveness of diagnosing obstructive sleep apnea (OSA) could be improved by using a preliminary screening method among subjects with no suspicion of other sleep disorders. We aimed to evaluate the diagnostic value of periodic snoring sound recorded at home. Methods: We included 211 subjects, aged 18–83 (130 men), who were referred to our laboratory for suspicion of OSA, and had a technically successful overnight polygraphy, measured with the Nox T3 Sleep Monitor (Nox Medical, Iceland) with a built-in microphone. We analyzed the percentage of periodic... περισσότερα »
Pediatric Positive Airway Pressure Adherence in Obstructive Sleep Apnea Enhanced by Family Member Positive Airway Pressure Usage
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Study Objectives: Adherence to positive airway pressure (PAP) therapy for obstructive sleep apnea (OSA) remains a challenge in children. We hypothesized that the presence of another family member on PAP therapy (parent, sibling, other family member) would be associated with better adherence in the child. Methods: We conducted a retrospective chart review to identify children < 18 years of age who had a new diagnosis of OSA between Jan 2011 and May 2013. Outcomes were objective PAP adherence at 1 week, 1 month, and 3 months. Potential predictors included family member on PAP thera... περισσότερα »
Restless Legs Syndrome in a Nigerian Elderly Population
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Study Objectives: The prevalence of restless legs syndrome (RLS) is highest in the elderly in Caucasian populations; the prevalence of RLS in elderly Africans is not known. This study aimed at determining the frequency and associations of RLS in a Nigerian elderly population. Methods: The study population comprised of 633 consecutive elderly individuals aged 65–105 years attending the general outpatient clinic of the State Hospital, Ilesa, for minor complaints and routine check-up. The diagnosis of RLS was made using the 2003 minimal criteria of the International Restless Legs S... περισσότερα »
Interest in Information about Nightmares in Patients with Sleep Disorders
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Study Objectives: Despite the considerable prevalence of the nightmare disorder and its burden on the patient, nightmares are underdiagnosed and undertreated, even in sleep centers. Methods: A total of 1,125 patients in a sleep center undergoing routine diagnostic procedures for their sleep disorders completed a questionnaire about nightmares. Results: About 20% of the sample indicated an interest in more information about nightmare etiology and nightmare therapy—even patients who had never sought professional help previously. Conclusions: From a clinical viewpoint, health ca... περισσότερα »
Evolution of Obstructive Sleep Apnea in Infants with Cleft Palate and Micrognathia
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Study Objectives: Children with craniofacial anomalies are a heterogeneous group at high risk for obstructive sleep apnea (OSA). However, the prevalence and structural predictors of OSA in this population are unknown. We hypothesized that infants with micrognathia would have more significant OSA than those with isolated cleft palate ± cleft lip (ICP), and those with ICP would have more significant OSA than controls. We postulated that OSA severity would correlate with reduced mandibular size, neurodevelopmental scores, and growth. Methods: Prospective cohort study. 15 infants wi... περισσότερα »
Use of Selective Serotonin Reuptake Inhibitors and Sleep Quality: A Population-Based Study
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Study Objectives: Poor sleep is a risk factor for the development and recurrence of depression. Selective serotonin reuptake inhibitor (SSRI) use is consistently associated with good subjective sleep in clinically depressed patient populations. However, studies in the general population are lacking. Our objective was to investigate the association between SSRIs and subjective sleep in a middle-aged and elderly population in a daily practice setting. Methods: We included participants from the prospective Rotterdam Study cohort. Participants had up to two subjective sleep measurem... περισσότερα »
Obese Veterans Enrolled in a Veterans Affairs Medical Center Outpatient Weight Loss Clinic Are Likely to Experience Disordered Sleep and Posttraumatic Stress
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Study Objectives: This cross-sectional study aimed to characterize sleep patterns, the quality and duration of sleep, and estimate the prevalence of common sleep disorders and posttraumatic stress disorder (PTSD) in a hospital-based Veterans Affairs MOVE! (Managing Overweight Veterans Everywhere) clinic. Methods: Participants completed five instruments: the Pittsburgh Sleep Quality Index (PSQI), Smith's Measure of Morningness/Eveningness, Restless Legs Syndrome Rating Scale, the STOP Questionnaire, and the Posttraumatic Stress Disorder (PTSD) Checklist – Civilian Version (PCL-C).... περισσότερα »
Nocturnal Hot Flashes: Relationship to Objective Awakenings and Sleep Stage Transitions
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Study Objectives: While women report sleep interruption secondary to nighttime hot flashes, the sleep disrupting impact of nocturnal hot flashes (HF) is not well characterized. We utilized a model of induced HF to investigate the relationship of nighttime HF to sleep architecture and sleep-stage transitions. Methods: Twenty-eight healthy, premenopausal volunteers received the depot gonadotropin-releasing hormone agonist (GnRHa) leuprolide to rapidly induce menopause, manifesting with HF. Sleep disruption was measured on 2 polysomnograms conducted before and after 4–5 weeks on le... περισσότερα »
Circadian Sleep Propensity and Alcohol Interaction at the Wheel
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Study Objectives: The study was aimed at estimating the effect of alcohol consumption, time of day, and their interaction on traffic crashes in a real regional context. Methods: Blood alcohol concentration (BAC) data were collected from drivers involved in traffic accidents during one year in an Italian region and in a control group of drivers over the same road network. Mean circadian sleep propensity was estimated from a previous study as function of time of day. Accident risk was analyzed by logistic regression as function of BAC and circadian sleep propensity. Results: BAC ... περισσότερα »
Effect of Continuous Positive Airway Pressure on Stroke Rehabilitation: A Pilot Randomized Sham-Controlled Trial
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Study Objectives: Obstructive sleep apnea (OSA) predicts poor functional outcome after stroke and increases the risk for recurrent stroke. Less is known about continuous positive airway pressure (CPAP) treatment on stroke recovery. Methods: In a pilot randomized, double-blind, sham-controlled trial, adult stroke rehabilitation patients were assigned to auto-titrating or sham CPAP without diagnostic testing for OSA. Change in Functional Independence Measure (FIM), a measure of disability, was assessed between rehabilitation admission and discharge. Results: Over 18 months, 40 pa... περισσότερα »
Rapid Eye Movement Sleep Abnormalities in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Study Objectives: Polysomnographic investigation of sleep architecture in children presenting with pediatric acute-onset neuropsychiatric syndrome (PANS). Methods: Fifteen consecutive subjects meeting criteria for PANS (mean age = 7.2 y; range 3–10 y) underwent single-night full polysomnography (PSG) read by a pediatric neurologist. Results: Thirteen of 15 subjects (87%) had abnormalities detected with PSG. Twelve of 15 had evidence of rapid eye movement (REM) sleep motor disinhibition, as characterized by excessive movement, laughing, hand stereotypies, moaning, or the continu... περισσότερα »
TRAIL-Armed Exosomes as a Novel Antitumor Therapy
*Purpose:* Exosomes deliver signals to target cells and could thus be exploited as an innovative therapeutic tool. We investigated the ability of membrane TRAIL-armed exosomes to deliver proapoptotic signals to cancer cells and mediate growth inhibition in different tumor models. *Experimental Methods and Results:* K562 cells, transduced with lentiviral human membrane TRAIL, were used for the production of TRAIL+ exosomes, which were studied by nanoparticle tracking analysis, cytofluorimetry, immunoelectronmicroscopy, Western blot, and ELISA. *In vitro*, TRAIL+ exosomes induced mo... περισσότερα »
HABP2 G534E Mutation in Familial Nonmedullary Thyroid Cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/2a2Dt3T via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Repeat Prostate-Specific Antigen Tests Before Prostate Biopsy Decisions
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
Despite limited scientific support, a repeat prostate-specific antigen (PSA) test before prostate biopsy decisions is common. We analyzed biopsy outcomes in 1686 men from the STHLM3 study with PSA 3-10 ng/mL and two PSA tests taken within eight weeks and before prostate biopsy using percentages and multinomial logistic regression. We found that omitting prostate biopsy […]
Eradication of Helicobacter pylori and Gastric Cancer: A Systematic Review and Meta-analysis of Cohort Studies
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
Background: Helicobacter pylori (H. pylori) is associated with an increased risk of gastric adenocarcinoma and gastric mucosa associated lymphoid tissue (MALT) lymphoma and a decreased risk of esophageal adenocarcinoma. We aimed to assess how eradication therapy for H. pylori influences the risk of developing these cancers. Methods: This was a systematic review and meta-analysis. We […]
Adherence to the World Cancer Research Fund/American Institute for Cancer Research lifestyle recommendations in colorectal cancer survivors: results of the PROFILES registry
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
Abstract We examined adherence to the eight The World Cancer Research Foundation/American Institute for Cancer Research (WCRF/AICR) recommendations on diet, physical activity, and body weight among colorectal cancer survivors, and whether adherence was associated with intention to eat healthy and with the need for dietary advice. Adherence to these recommendations may putatively reduce the risk […]
Remote triage support algorithm based on fuzzy logic
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
Objectives This paper presents a remote triage support algorithm as a part of a complex military telemedicine system which provides continuous monitoring of soldiers’ vital sign data gathered on-site using unobtrusive set of sensors. Methods The proposed fuzzy logic-based algorithm takes physiological data and classifies the casualties according to their health risk level, calculated following […]
Correction: Absolute Effect of Prostate Cancer Screening: Balance of Benefits and Harms by Center within the European Randomized Study of Prostate Cancer Screening
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29zkLA8 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Correction: The Notch Target Hes1 Directly Modulates Gli1 Expression and Hedgehog Signaling: A Potential Mechanism of Therapeutic Resistance
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29AIw7z via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Correction: Molecular Pathways: IDH2 Mutations–Co-opting Cellular Metabolism for Malignant Transformation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29UfGjZ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
MET DNA Alterations in NSCLC–Letter
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29UID25 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Holbrook Kohrt: In Memoriam (1977-2016)
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 34 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29Ug6Hf via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Linear epitope mapping of peanut allergens demonstrates individualized and persistent antibody binding patterns
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Single amino acid resolution mapping of linear peanut allergen epitopes using high density peptide arrays demonstrates patient specific and highly persistent antibody binding patterns. http://ift.tt/2aeaPcI http://ift.tt/29CbXoG
IL-22 derived from γδ T cells restricts Staphylococcus aureus infection of mechanically injured skin
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
IL-22 induction by mechanical injury limits cutaneous infection of Staphylococcus aureus. http://ift.tt/29Io5Y6 http://ift.tt/29SIv1K
Assessing basophil activation by flow cytometry and mass cytometry in blood stored 24 hours before analysis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Blood collected in heparin and stored at 4°C for 24 hours can be used to quantify upregulation of basophil CD203c and CD63hi basophils, either by conventional flow cytometry or Cytometry by Time-of-Flight mass spectrometry. http://ift.tt/2aeaJSe http://ift.tt/29Cc17R
Treatment Effect of Sublingual Immunotherapy Tablets and Pharmacotherapies for Seasonal and Perennial Allergic Rhinitis: Pooled Analyses
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
By indirect comparison, SLIT-tablet effects on nasal symptoms were nearly as large as an intranasal corticosteroid, and numerically greater than montelukast or an antihistamine for SAR. HDM SLIT-tablets were numerically greater versus all pharmacotherapies for PAR. http://ift.tt/2aeaert http://ift.tt/29SIMBP
Humoral and cellular responses to casein in food protein-induced enterocolitis to cow’s milk
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
We confirm the paucity of humoral responses in cow milk FPIES. Our data indirectly suggest a major role of neutrophils and mast cells in FPIES. In addition, IL-10 may play a role in tolerance acquisition. http://ift.tt/29InHcc http://ift.tt/29Cck2H
Platelet-activating factor decreases skin keratinocyte tight junction barrier integrity
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
http://ift.tt/2aeakzi http://ift.tt/29SIB9s
“The False Alarm” hypothesis: Food allergy is associated with high dietary advanced glycation end products and pro-glycating dietary sugars that mimic alarmins
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
The incidence of food allergy has risen dramatically in the last few decades in Westernized developed countries. We propose that the Western life style and diet promote innate danger signals and immune responses through the production of “alarmins”. Alarmins are endogenous molecules secreted from cells undergoing non-programmed cell death that signal tissue and cell damage. […]
Mutations in LAT lead to a novel form of severe combined immunodeficiency
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Severe combined immunodeficiency can arise from a number of different genetic causes. Here, we show that mutations in LAT can lead to SCID and highlight the critical role of LAT in TCR signalling in T cell development. http://ift.tt/2aea5nR http://ift.tt/29SIkn1
Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
This article examines the mechanism of action underlying the allergy-protective effects of the cowshed bacterium, Lactococcus lactis G121. The mechanism involves bacterial uptake by DCs, followed by endosomal acidification and sensing of bacterial RNA by endosomal pattern recognition receptors. http://ift.tt/29InYfq http://ift.tt/29Cc97q
IgE-reactivity profiles to non-specific Lipid Transfer Proteins (ns-LTP) in a north-western European country
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Specific IgE reactivity to ns-LTPs is prevalent in patients with pollen and/or plant food allergic symptoms from a north-western European region, although in the majority of cases these sIgE antibodies appear not clinically relevant. http://ift.tt/29Io8Ds http://ift.tt/29SIFWV
Mutations in LAT lead to a novel form of severe combined immunodeficiency
Severe combined immunodeficiency can arise from a number of different genetic causes. Here, we show that mutations in LAT can lead to SCID and highlight the critical role of LAT in TCR signalling in T cell development. http://ift.tt/2aea5nR http://ift.tt/29SIkn1 OtoRhinoLaryngology by Alexandros G. Sfakianakis
IL-22 derived from γδ T cells restricts Staphylococcus aureus infection of mechanically injured skin
IL-22 induction by mechanical injury limits cutaneous infection of Staphylococcus aureus. http://ift.tt/29Io5Y6 http://ift.tt/29SIv1K OtoRhinoLaryngology by Alexandros G. Sfakianakis
Linear epitope mapping of peanut allergens demonstrates individualized and persistent antibody binding patterns
Single amino acid resolution mapping of linear peanut allergen epitopes using high density peptide arrays demonstrates patient specific and highly persistent antibody binding patterns. http://ift.tt/2aeaPcI http://ift.tt/29CbXoG OtoRhinoLaryngology by Alexandros G. Sfakianakis
Assessing basophil activation by flow cytometry and mass cytometry in blood stored 24 hours before analysis
Blood collected in heparin and stored at 4°C for 24 hours can be used to quantify upregulation of basophil CD203c and CD63hi basophils, either by conventional flow cytometry or Cytometry by Time-of-Flight mass spectrometry. http://ift.tt/2aeaJSe http://ift.tt/29Cc17R OtoRhinoLaryngology by Alexandros G. Sfakianakis
IgE-reactivity profiles to non-specific Lipid Transfer Proteins (ns-LTP) in a north-western European country
Specific IgE reactivity to ns-LTPs is prevalent in patients with pollen and/or plant food allergic symptoms from a north-western European region, although in the majority of cases these sIgE antibodies appear not clinically relevant. http://ift.tt/29Io8Ds http://ift.tt/29SIFWV OtoRhinoLaryngology by Alexandros G. Sfakianakis
Treatment Effect of Sublingual Immunotherapy Tablets and Pharmacotherapies for Seasonal and Perennial Allergic Rhinitis: Pooled Analyses
By indirect comparison, SLIT-tablet effects on nasal symptoms were nearly as large as an intranasal corticosteroid, and numerically greater than montelukast or an antihistamine for SAR. HDM SLIT-tablets were numerically greater versus all pharmacotherapies for PAR. http://ift.tt/2aeaert http://ift.tt/29SIMBP OtoRhinoLaryngology by Alexandros G. Sfakianakis
“The False Alarm” hypothesis: Food allergy is associated with high dietary advanced glycation end products and pro-glycating dietary sugars that mimic alarmins
The incidence of food allergy has risen dramatically in the last few decades in Westernized developed countries. We propose that the Western life style and diet promote innate danger signals and immune responses through the production of "alarmins". Alarmins are endogenous molecules secreted from cells undergoing non-programmed cell death that signal tissue and cell damage. High Molecular Group Box 1 (HMGB1) is a major alarmin that binds to the Receptor for Advanced Glycation End products (RAGE). http://ift.tt/29IooCx http://ift.tt/29Ccbfy OtoRhinoLaryngology by Alexandros G. Sfa... περισσότερα »
Humoral and cellular responses to casein in food protein-induced enterocolitis to cow’s milk
We confirm the paucity of humoral responses in cow milk FPIES. Our data indirectly suggest a major role of neutrophils and mast cells in FPIES. In addition, IL-10 may play a role in tolerance acquisition. http://ift.tt/29InHcc http://ift.tt/29Cck2H OtoRhinoLaryngology by Alexandros G. Sfakianakis
Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects
This article examines the mechanism of action underlying the allergy-protective effects of the cowshed bacterium, Lactococcus lactis G121. The mechanism involves bacterial uptake by DCs, followed by endosomal acidification and sensing of bacterial RNA by endosomal pattern recognition receptors. http://ift.tt/29InYfq http://ift.tt/29Cc97q OtoRhinoLaryngology by Alexandros G. Sfakianakis
Platelet-activating factor decreases skin keratinocyte tight junction barrier integrity
http://ift.tt/2aeakzi http://ift.tt/29SIB9s OtoRhinoLaryngology by Alexandros G. Sfakianakis
Diversity of T-helper cytokine-profiles in chronic rhinosinusitis: A multicenter study in Europe, Asia and Oceania
This study for the first time evaluates inflammatory patterns based on T-helper cell cytokines and granulocyte inflammation markers in patients with chronic rhinosinusitis from different continents, identifying various compositions of endotypes within the clinical phenotypes. http://ift.tt/2aeb9bd http://ift.tt/29H4lqD OtoRhinoLaryngology by Alexandros G. Sfakianakis
TRAIL-Armed Exosomes as a Novel Antitumor Therapy
*Purpose:* Exosomes deliver signals to target cells and could thus be exploited as an innovative therapeutic tool. We investigated the ability of membrane TRAIL-armed exosomes to deliver proapoptotic signals to cancer cells and mediate growth inhibition in different tumor models. *Experimental Methods and Results:* K562 cells, transduced with lentiviral human membrane TRAIL, were used for the production of TRAIL+ exosomes, which were studied by nanoparticle tracking analysis, cytofluorimetry, immunoelectronmicroscopy, Western blot, and ELISA. *In vitro*, TRAIL+ exosomes induced mo... περισσότερα »
ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models
Background Despite current therapies, glioblastoma is a devastating cancer, and validation of effective biomarkers for it will enable better diagnosis and therapeutic intervention for this disease. We recently discovered a new biomarker for high-grade gliomas, ELTD1 (epidermal growth factor, latrophilin, and 7 transmembrane domain-containing protein 1 on chromosome 1) via bioinformatics, and validated that ELTD1 protein levels are significantly higher in human and rodent gliomas. The focus of this study was to assess the effect on tumor growth of an antibody against ELTD1 in ort... περισσότερα »
Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults
Background Astroblastomas (ABs) are rare glial tumors showing overlapping features with astrocytomas, ependymomas, and sometimes other glial neoplasms, and may be challenging to diagnose. Methods We examined clinical, histopathological, and molecular features in 28 archival formalin-fixed, paraffin-embedded AB cases and performed survival analyses using Cox proportional hazards and Kaplan–Meier methods. Results Unlike ependymomas and angiocentric gliomas, ABs demonstrate abundant distinctive astroblastic pseudorosettes and are usually Olig2 immunopositive. They also frequently... περισσότερα »
Correcting for Measurement Error in Time-Varying Covariates in Marginal Structural Models
Unbiased estimation of causal parameters from marginal structural models (MSMs) requires a fundamental assumption of no unmeasured confounding. Unfortunately, the time-varying covariates used to obtain inverse probability weights are often error-prone. Although substantial measurement error in important confounders is known to undermine control of confounders in conventional unweighted regression models, this issue has received comparatively limited attention in the MSM literature. Here we propose a novel application of the simulation-extrapolation (SIMEX) procedure to address mea... περισσότερα »
Can the Heterosexual HIV Epidemic be Eliminated in South Africa Using Combination Prevention? A Modeling Analysis
Little is known about how combining efficacious interventions for human immunodeficiency virus (HIV) prevention could lead to HIV elimination. We used an agent-based simulation model, the HIV calibrated dynamic model, to assess the potential for HIV elimination in South Africa. We examined several scenarios (from continuation of the current status quo to perfect achievement of targets) with differing combinations of male condom use, adult male circumcision, HIV testing, and early antiretroviral therapy (ART). We varied numerous parameters, including the proportion of adult males c... περισσότερα »
Obstructive sleep apnea and energy balance regulation: A systematic review
Obesity and obstructive sleep apnea (OSA) have a reciprocal relationship. Sleep disruptions characteristic of OSA may promote behavioral, metabolic, and/or hormonal changes favoring weight gain and/or difficulty losing weight. The regulation of energy balance (EB), i.e. the relationship between energy intake (EI) and energy expenditure (EE), is complex and multi-factorial, involving food intake, hormonal regulation of hunger/satiety/appetite, and EE via metabolism and physical activity (PA). The current systematic review describes the literature on how OSA affects EB-related param... περισσότερα »
Rhinoplasty
*Nose Reshaping Surgery* [image: nose reshaping surgery] This is a cosmetic procedure that is also known as nose job. There a number of reasons the procedure is performed . In this article, we will discuss that reasons of Rhinoplasty is best for you. Rhionoplasty is just one of the various plastic surgery procedures such as facelift, breast implants, liposuction, dermal fillers and few more. For more details, browse more at – http://ift.tt/2aekrnw These are: - To make small nose bigger - To make big nose small - To make the nostril span narrower - Alter the appearance ... περισσότερα »
Is there heightened sensitivity to social reward in adolescence?
[image: S09594388.gif] Publication date: October 2016 *Source:*Current Opinion in Neurobiology, Volume 40 Author(s): Lucy Foulkes, Sarah-Jayne Blakemore During adolescence, individuals are particularly susceptible to social influence. One explanation for this is that social stimuli have a heightened reward value at this age. To date, most evidence for heightened social reward in adolescence is found in the animal literature. Human adolescents show increased activation in fronto-striatal brain regions to rewarding social stimuli, but also to negative social stimuli, suggesting that a... περισσότερα »
Dynamic network interactions supporting internally-oriented cognition
Publication date: October 2016 *Source:*Current Opinion in Neurobiology, Volume 40 Author(s): Darya L Zabelina, Jessica R Andrews-Hanna Recent advances in systems neuroscience have solidified the view that many cognitive processes are supported by dynamic interactions within and between large-scale brain networks. Here we synthesize this research, highlighting dynamic network interactions supporting a less explored aspect of cognition with important clinical relevance: internally-oriented cognition. We first present a brief overview of established resting-state networks, focusing on... περισσότερα »
From the optic tectum to the primary visual cortex: migration through evolution of the saliency map for exogenous attentional guidance
[image: S09594388.gif] Publication date: October 2016 *Source:*Current Opinion in Neurobiology, Volume 40 Author(s): Li Zhaoping Recent data have supported the hypothesis that, in primates, the primary visual cortex (V1) creates a saliency map from visual input. The exogenous guidance of attention is then realized by means of monosynaptic projections to the superior colliculus, which can select the most salient location as the target of a gaze shift. V1 is less prominent, or is even absent in lower vertebrates such as fish; whereas the superior colliculus, called optic tectum in low... περισσότερα »
Evaluation of Low-Dose Ultraviolet Light C for Reduction of Select ESKAPE Pathogens in a Canine Skin and Muscle Model
Photomedicine and Laser Surgery , Vol. 0, No. 0. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/2a2Bs7Y via IFTTT
The Use of the Er:YAG Laser for Bracket Debonding and Its Effect on Enamel Damage
Photomedicine and Laser Surgery , Vol. 0, No. 0. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/29X9Qy5 via IFTTT
The Effectiveness of Low-Level Laser Therapy in Patients with Drug-Induced Hyposalivation: A Pilot Study
Photomedicine and Laser Surgery , Vol. 0, No. 0. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/2a2Bpc4 via IFTTT
Factors associated with benign multiple sclerosis in the New York State MS Consortium (NYSMSC)
This retrospective analysis explored prognostic factors associated with a benign multiple sclerosis (BMS) disease course at baseline and over the 4-year follow-up. from Neurology via xlomafota13 on Inoreader http://ift.tt/2a2BRag via IFTTT
Anomalous vascularization in a Wnt medulloblastoma: a case report
Medulloblastoma is the most common malignant brain tumor in children. To date only few cases of medulloblastoma with hemorrhages have been reported in the literature. Although some studies speculate on the pat... from Neurology via xlomafota13 on Inoreader http://ift.tt/29X9RSM via IFTTT
ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models
Background Despite current therapies, glioblastoma is a devastating cancer, and validation of effective biomarkers for it will enable better diagnosis and therapeutic intervention for this disease. We recently discovered a new biomarker for high-grade gliomas, ELTD1 (epidermal growth factor, latrophilin, and 7 transmembrane domain-containing protein 1 on chromosome 1) via bioinformatics, and validated that ELTD1 protein levels are significantly higher in human and rodent gliomas. The focus of this study was to assess the effect on tumor growth of an antibody against ELTD1 in ort... περισσότερα »
Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults
Background Astroblastomas (ABs) are rare glial tumors showing overlapping features with astrocytomas, ependymomas, and sometimes other glial neoplasms, and may be challenging to diagnose. Methods We examined clinical, histopathological, and molecular features in 28 archival formalin-fixed, paraffin-embedded AB cases and performed survival analyses using Cox proportional hazards and Kaplan–Meier methods. Results Unlike ependymomas and angiocentric gliomas, ABs demonstrate abundant distinctive astroblastic pseudorosettes and are usually Olig2 immunopositive. They also frequently... περισσότερα »
Effect of sampling rate and filter settings on High Frequency Oscillation detections
High frequency oscillations (HFOs) are short, rare events with high power in approximately 80-500 Hz and have been suggested as a biomarker of epilepsy (Bragin et al., 2002; Engel et al., 2009; Wu et al., 2010; Blanco et al., 2011; Park et al., 2012; Haegelen et al., 2013; Kerber et al., 2014). Research often focuses on HFOs as a biomarker of ictal onset tissue (Cho et al., 2014; Dumpelmann et al., 2014; Malinowska et al., 2014; Okanishi et al., 2014; Gliske et al., 2016). HFOs have also been considered as a biomarker of a pre-ictal state (Pearce et al., 2013; Malinowska et al., 2... περισσότερα »
Factors associated with benign multiple sclerosis in the New York State MS Consortium (NYSMSC)
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
This retrospective analysis explored prognostic factors associated with a benign multiple sclerosis (BMS) disease course at baseline and over the 4-year follow-up. http://ift.tt/2a2BRag
Anomalous vascularization in a Wnt medulloblastoma: a case report
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Medulloblastoma is the most common malignant brain tumor in children. To date only few cases of medulloblastoma with hemorrhages have been reported in the literature. Although some studies speculate on the pat... http://ift.tt/29X9RSM
Impacts of human activities on distribution of sulfate-reducing prokaryotes and antibiotic resistance genes in marine coastal sediments of Hong Kong
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Sulfate-reducing prokaryotes (SRPs) and antibiotic resistance genes (ARGs) in sediments could be biomarkers for evaluating the environmental impacts of human activities, although factors governing their distribution are not clear yet. By using metagenomic approach, this study investigated the distributions of SRPs and ARGs in marine sediments collected from 12 different coastal locations of Hong Kong, which exhibited different pollution levels and were classified into two groups based on sediment parameters. Our results showed that relative abundances of major SRP genera to total ... περισσότερα »
Unravelling the interactions among microbial populations found in activated sludge during biofilm formation
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Microorganisms colonize surfaces and develop biofilms through interactions that are not yet thoroughly understood, with important implications for water and wastewater systems. This study investigated the interactions between *N-*acyl homoserine lactone (AHL)-producing bacteria, yeasts and protists, and their contribution to biofilm development. Sixty-one bacterial strains were isolated from activated sludge and screened for AHL production, with *Aeromonas* sp. found to be the dominant AHL producer*. Shewanella xiamenensis*, *Aeromonas allosaccharophila*, *Acinetobacter junii* and... περισσότερα »
Spatial and taxonomical overlap of fungi on phylloplanes and invasive alien ladybirds with fungal infections in tree crowns of urban green spaces
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Occurrence of entomopathogenic fungi on phylloplanes in *Tilia* x europaea crowns between 1 and 13 m was assessed in urban parks. Prevalence of fungal infections in ladybirds (Coleoptera: Coccinellidae) collected from *Tilia* x europaea was assessed to determine whether fungi found on phylloplanes also occurred as infections in ladybirds. *Isaria* spp. was most abundant on phylloplanes (mean colony forming units (CFU) per leaf ± SE, 0.33 ± 0.03) followed by *Beauveria* spp. (0.22 ± 0.02 CFU per leaf) and *Lecanicillium* spp. (0.19 ± 0.02 CFU per leaf). Densities of inoculum were h... περισσότερα »
Effects of endophytic fungi on the ash dieback pathogen
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
While *Hymenoscyphus fraxineus* causes dieback of the European ash (*Fraxinus excelsior*), flowering ash (*F. ornus*) appears resistant to the pathogen. To date, contributions of endophytic fungi to host resistance are unknown. The following hypotheses were tested: (i) endophytic fungi enhance the resistance of *F. excelsior* to the pathogen; (ii) resistance of *F. ornus* relies on its community of endophytic fungi. Two experiments were performed. (i) The effect of exudates of ash endophytes on the germination rate of *H. fraxineus* ascospores was studied *in vitro*. Isolates of a... περισσότερα »
Evaluation of Low-Dose Ultraviolet Light C for Reduction of Select ESKAPE Pathogens in a Canine Skin and Muscle Model
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Photomedicine and Laser Surgery , Vol. 0, No. 0. http://ift.tt/2a2Bs7Y
The Use of the Er:YAG Laser for Bracket Debonding and Its Effect on Enamel Damage
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Photomedicine and Laser Surgery , Vol. 0, No. 0. http://ift.tt/29X9Qy5
The Effectiveness of Low-Level Laser Therapy in Patients with Drug-Induced Hyposalivation: A Pilot Study
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Photomedicine and Laser Surgery , Vol. 0, No. 0. http://ift.tt/2a2Bpc4
Decoding molecular interactions in microbial communities
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Microbial communities govern numerous fundamental processes on earth. Discovering and tracking molecular interactions among microbes is critical for understanding how single species and complex communities impact their associated host or natural environment. While recent technological developments in DNA sequencing and functional imaging have led to new and deeper levels of understanding, we are limited now by our inability to predict and interpret the intricate relationships and interspecies dependencies within these communities. In this review, we highlight the multifaceted appr... περισσότερα »
ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Background Despite current therapies, glioblastoma is a devastating cancer, and validation of effective biomarkers for it will enable better diagnosis and therapeutic intervention for this disease. We recently discovered a new biomarker for high-grade gliomas, ELTD1 (epidermal growth factor, latrophilin, and 7 transmembrane domain-containing protein 1 on chromosome 1) via bioinformatics, and validated that ELTD1 protein levels are significantly higher in human and rodent gliomas. The focus of this study was to assess the effect on tumor growth of an antibody against ELTD1 in ort... περισσότερα »
Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Background Astroblastomas (ABs) are rare glial tumors showing overlapping features with astrocytomas, ependymomas, and sometimes other glial neoplasms, and may be challenging to diagnose. Methods We examined clinical, histopathological, and molecular features in 28 archival formalin-fixed, paraffin-embedded AB cases and performed survival analyses using Cox proportional hazards and Kaplan–Meier methods. Results Unlike ependymomas and angiocentric gliomas, ABs demonstrate abundant distinctive astroblastic pseudorosettes and are usually Olig2 immunopositive. They also frequently... περισσότερα »
Anatomical and functional deficiencies of the crural diaphragm in patients with esophagitis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Background Inspiratory esophagogastric junction (EGJ) pressure is lower in gastroesophageal reflux disease (GERD) and patients fail to increase EGJ pressure during the inspiratory effort. The aim of this study was to assess the EGJ activity during inspiratory maneuvers (high-resolution manometry, HRM) and the crural diaphragm (CD) thickness (endoscopic ultrasound, EUS) in GERD. Methods Twenty esophagitis patients (average age 45 years, 7 grade A, 13 grade B) had HRM and EUS. Forty-three controls were recruited; 30 had HRM (average age 33 years), and 13 had EUS (average ... περισσότερα »
Agreement of Different Methods for Tissue Based Detection of HER2 Signal in Invasive Breast Cancer
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Breast cancer is the second leading cause of cancer mortality amongst American women. The HER2 gene encodes a cell surface receptor that affects cell proliferation and has been recognized as a diagnostic factor in treatment selection for invasive breast cancer. Examine accuracy in HER2 detection between manual count, computer assisted, and automated tiling algorithm. 42 randomly selected invasive breast cancer specimens were enumerated by fluorescence in situ hybridization (FISH)for HER2 and CEP17 markers using the Vysis HER2 assay (AbbotLaboratory, North Chicago, IL). Sp... περισσότερα »
Quality of life differences in patients with right-versus left-sided facial paralysis: Universal preference of right-sided human face recognition
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
The face is a crucial source of information in recognizing a person's identity. Recent studies have indicated that neural mechanisms of the right anterior temporal lobe are involved in recognizing facial identity. This hemispheric laterality can affect human face recognition depending on the target side of the face.In this study, we investigated whether experiencing right- or left-sided facial paralysis would affect an individual's ability to recognize one side of the human face using hybrid hemi-facial photos by preliminary study. http://ift.tt/29N1om7
Reply: Complications in unilateral versus bilateral deep inferior epigastric artery perforator flap breast reconstructions: A multicentre study
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
We read with great interest the comments by Wade et al. regarding our recently published study on the complications in unilateral versus bilateral DIEP flap breast reconstructions.1 We appreciate the critical analysis of our results and the intention to show the importance of the unit of analysis. However, we feel that it is necessary to discuss some issues raised in their letter.2 http://ift.tt/29GkW7S
Reliability of the “Ten Test” for assessment of discriminative sensation in hand trauma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
"Ten Test" (TT) is a bedside measure of discriminative sensation, whereby the magnitude of abnormal sensation to moving light touch is normalized to an area of normal sensation on an 11-point Likert scale (0-10). The purposes of this study were to determine reliability parameters of the TT in a cohort of patients presenting to a hand trauma clinic with subjectively altered sensation post-injury and to compare the reliability of TT to that of the Weinstein Enhanced Sensory Test (WEST). Study participants (n=29, mean age=37±12) comprised patients presenting to an outpatient hand tra... περισσότερα »
Assessing the Midface in Muenke Syndrome: A Cephalometric Analysis and Review of the Literature
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Max Muenke included midface hypoplasia as part of the clinical syndrome caused by the Pro250Arg FGFR3 mutation that now bears his name. Murine models have demonstrated midface hypoplasia in homozygous recessive mice only, with heterozygotes having normal midfaces; as the majority of humans with the syndrome are heterozygotes, we investigated the incidence of midface hypoplasia in our institution's clinical cohort. http://ift.tt/29GjrXw
Effect of sampling rate and filter settings on High Frequency Oscillation detections
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
High frequency oscillations (HFOs) are short, rare events with high power in approximately 80-500 Hz and have been suggested as a biomarker of epilepsy (Bragin et al., 2002; Engel et al., 2009; Wu et al., 2010; Blanco et al., 2011; Park et al., 2012; Haegelen et al., 2013; Kerber et al., 2014). Research often focuses on HFOs as a biomarker of ictal onset tissue (Cho et al., 2014; Dumpelmann et al., 2014; Malinowska et al., 2014; Okanishi et al., 2014; Gliske et al., 2016). HFOs have also been considered as a biomarker of a pre-ictal state (Pearce et al., 2013; Malinowska et al., 2... περισσότερα »
Response
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
http://ift.tt/29LAZpP
Serrated lesions in inflammatory bowel disease
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
http://ift.tt/2a2nPFH
Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value – usefulness of immunostaining for EZH2 and p16INK4a in differentiating it from cholangiolocellular carcinoma – Confluent hepatic fibrosis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
http://ift.tt/29z8YlB
Reliability of the “Ten Test” for assessment of discriminative sensation in hand trauma
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
«Ten Test» (TT) is a bedside measure of discriminative sensation, whereby the magnitude of abnormal sensation to moving light touch is normalized to an area of normal sensation on an 11-point Likert scale (0-10). The purposes of this study were to determine reliability parameters of the TT in a cohort of patients presenting to a […]
Assessing the Midface in Muenke Syndrome: A Cephalometric Analysis and Review of the Literature
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Max Muenke included midface hypoplasia as part of the clinical syndrome caused by the Pro250Arg FGFR3 mutation that now bears his name. Murine models have demonstrated midface hypoplasia in homozygous recessive mice only, with heterozygotes having normal midfaces; as the majority of humans with the syndrome are heterozygotes, we investigated the incidence of midface hypoplasia […]
Effect of sampling rate and filter settings on High Frequency Oscillation detections
High frequency oscillations (HFOs) are short, rare events with high power in approximately 80-500 Hz and have been suggested as a biomarker of epilepsy (Bragin et al., 2002; Engel et al., 2009; Wu et al., 2010; Blanco et al., 2011; Park et al., 2012; Haegelen et al., 2013; Kerber et al., 2014). Research often focuses on HFOs as a biomarker of ictal onset tissue (Cho et al., 2014; Dumpelmann et al., 2014; Malinowska et al., 2014; Okanishi et al., 2014; Gliske et al., 2016). HFOs have also been considered as a biomarker of a pre-ictal state (Pearce et al., 2013; Malinowska et al., 201... περισσότερα »
Decoding molecular interactions in microbial communities
Microbial communities govern numerous fundamental processes on earth. Discovering and tracking molecular interactions among microbes is critical for understanding how single species and complex communities impact their associated host or natural environment. While recent technological developments in DNA sequencing and functional imaging have led to new and deeper levels of understanding, we are limited now by our inability to predict and interpret the intricate relationships and interspecies dependencies within these communities. In this review, we highlight the multifaceted appr... περισσότερα »
Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society
It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances. These guidelines are intended for use by healthcare professionals who care for patients at risk for hospital-acquired pneumonia (HAP) and ventilator-asso... περισσότερα »
Ebola virus related encephalitis
Ebola patients present frequently behavioural modifications with ideation slowing and aggressiveness, sometimes contrasting with mild severity of Ebola disease. We performed lumbar punctures in three patients with this presentation and found Ebola virus in all cerebrospinal fluids. This discovery helps to discuss the concept of a specific Ebola virus encephalitis. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/29U6Xi0 via IFTTT
15 September News
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/29UzW7W via IFTTT
Zika Virus Infection Associated with Severe Thrombocytopenia
We report two patients who developed severe thrombocytopenia after Zika virus infection. The first had 1,000 platelets/mm3, and died following multiple hemorrhages. The second had 2,000 platelets/mm3, melena, ecchymoses, and recovered after receiving intravenous immunoglobulin. Physicians should be aware that Zika virus may be associated with immune-mediated severe thrombocytopenia. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/29U6yfd via IFTTT
Design, synthesis and preliminary bioactivity evaluations of N1-hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors
Abstract Histone deacetylases inhibitors (HDACIs) have been widely recognized as significant therapeutic approach to cancers. In our efforts to develop novel histone deacetylases inhibitors (HDACIs) as potential anticancer agents, a series of *N*1-hydroxyterephthalamide derivatives with an indole cap group were designed and synthesized. Compound *12m* was identified to be the most potent one (IC50=0.074μM against Hela nuclear extracts*)* and showed higher inhibitory activity than the positive control *SAHA* (IC50=0.131μM), which was also verified by further molecular docking studie... περισσότερα »
Agreement of Different Methods for Tissue Based Detection of HER2 Signal in Invasive Breast Cancer
Abstract Breast cancer is the second leading cause of cancer mortality amongst American women. The HER2 gene encodes a cell surface receptor that affects cell proliferation and has been recognized as a diagnostic factor in treatment selection for invasive breast cancer. Examine accuracy in HER2 detection between manual count, computer assisted, and automated tiling algorithm. 42 randomly selected invasive breast cancer specimens were enumerated by fluorescence in situ hybridization (FISH)for HER2 and CEP17 markers using the Vysis HER2 assay (AbbotLaboratory, North Chicago, IL). Sp... περισσότερα »
Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value – usefulness of immunostaining for EZH2 and p16INK4a in differentiating it from cholangiolocellular carcinoma – Confluent hepatic fibrosis
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The role of demonstrating anatomy for surgical trainees
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Sonographic evaluation of jugulodigastric and juguloomohyoid lymph nodes
Abstract *Introduction*: The jugulodigastric (JD) and juguloomohyoid (JO) lymph nodes are levels II and III cervical lymph nodes corresponding to the upper and middle internal jugular chains, respectively. The aim of this study is to delineate the sonographic properties of these two nodes, which are commonly encountered in routine neck sonography, in subjects with normal neck ultrasound findings. Atypical findings can make it difficult to differentiate benign from malignant lymph nodes. *Materials and Methods*: The JD and JO lymph nodes of 126 subjects were examined by ultrasonogr... περισσότερα »
Cadaveric and radiologic study of the anatomical variations of the prostatic arteries. A review of the literature and a new classification proposal
Abstract *Introduction*: Development of prostatic arterial embolization (PAE) to treat benign prostatic hyperplasia (BPH) has raised interest in the variations of the PA. The aim of this study is to identify these vascular variations, to compare them with previous data, and to propose a simple classification. *Materials and methods*: Ten adult male pelvis sides from embalmed cadavers were dissected, ages 69 to 92 years, and 10 PA were examined. In a retrospective analysis of 34 DSA pelvic angiographies on 28 patients aged 50 to 90 years, 48 PA were identified. A total of 58 PA wer... περισσότερα »
Anatomical and functional deficiencies of the crural diaphragm in patients with esophagitis
Abstract Background Inspiratory esophagogastric junction (EGJ) pressure is lower in gastroesophageal reflux disease (GERD) and patients fail to increase EGJ pressure during the inspiratory effort. The aim of this study was to assess the EGJ activity during inspiratory maneuvers (high-resolution manometry, HRM) and the crural diaphragm (CD) thickness (endoscopic ultrasound, EUS) in GERD. Methods Twenty esophagitis patients (average age 45 years, 7 grade A, 13 grade B) had HRM and EUS. Forty-three controls were recruited; 30 had HRM (average age 33 years), and 13 had EUS (average age... περισσότερα »
Medical professionals’ perspectives on prescribed and over-the-counter medicines containing codeine: a cross-sectional study
Objectives To explore prescribing practitioners’ perspectives on prescribed codeine use, their ability to identify dependence and their options for treatment in the UK. Design Cross-sectional design using a questionnaire containing closed-ended and open-ended items. Setting A nationally representative sample of prescribing professionals working in the UK. Participants 300 prescribing professionals working in primary care and… Continue reading Medical professionals’ perspectives on prescribed and over-the-counter medicines containing codeine: a cross-sectional study
Research studies on patients’ illness experience using the Narrative Medicine approach: a systematic review
Objective Since its birth about 30 years ago, Narrative Medicine approach has increased in popularity in the medical context as well as in other disciplines. This paper aims to review Narrative Medicine research studies on patients’ and their caregivers’ illness experience. Setting and participants MEDLINE, Psycinfo, EBSCO Psychological and Behavioural Science, The Cochrane Library and… Continue reading Research studies on patients’ illness experience using the Narrative Medicine approach: a systematic review
How older citizens engage in their health promotion: a qualitative research-driven taxonomy of experiences and meanings
Objectives In this qualitative study, we provide an in-depth exploration of older people’s experiences and subjective meanings concerning their engagement in health promotion as well as the emotional and pragmatic difficulties they face during their engagement. Methods The study was designed according to the ethnoscience method, which implies a participatory process that values patients’ linguistic… Continue reading How older citizens engage in their health promotion: a qualitative research-driven taxonomy of experiences and meanings
Complex social intervention for multidisciplinary teams to improve patient referrals in obstetrical care: protocol for a stepped wedge study design
Introduction In obstetrics, patients often experience referral situations between different care professionals. In these multidisciplinary teams, a focus on communication and interprofessional collaboration is needed to ensure care of high quality. Crew resource management team training is increasingly being applied in healthcare settings to improve team performance and coordination. Efforts to improve communication also include… Continue reading Complex social intervention for multidisciplinary teams to improve patient referrals in obstetrical care: protocol for a stepped wedge stu... περισσότερα »
Agreement of Different Methods for Tissue Based Detection of HER2 Signal in Invasive Breast Cancer
Abstract Breast cancer is the second leading cause of cancer mortality amongst American women. The HER2 gene encodes a cell surface receptor that affects cell proliferation and has been recognized as a diagnostic factor in treatment selection for invasive breast cancer. Examine accuracy in HER2 detection between manual count, computer assisted, and automated tiling algorithm.… Continue reading Agreement of Different Methods for Tissue Based Detection of HER2 Signal in Invasive Breast Cancer
Physicians’ assessments of work capacity in patients with severe subjective health complaints: a cross-sectional study on differences between five European countries
Objectives A comparison of appraisals made by general practitioners (GPs) in France and occupational physicians (OPs) and insurance physicians (IPs) in the Netherlands with those made by Scandinavian GPs on work capacity in patients with severe subjective health complaints (SHCs). Setting GPs in France and OPs/IPs in the Netherlands gathered to watch nine authentic video… Continue reading Physicians’ assessments of work capacity in patients with severe subjective health complaints: a cross-sectional study on differences between five European countries
Design, synthesis and preliminary bioactivity evaluations of N1-hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors
Abstract Histone deacetylases inhibitors (HDACIs) have been widely recognized as significant therapeutic approach to cancers. In our efforts to develop novel histone deacetylases inhibitors (HDACIs) as potential anticancer agents, a series of N1-hydroxyterephthalamide derivatives with an indole cap group were designed and synthesized. Compound 12m was identified to be the most potent one (IC50=0.074μM against… Continue reading Design, synthesis and preliminary bioactivity evaluations of N1-hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors
Mapping the progress and impacts of public health approaches to palliative care: a scoping review protocol
Introduction Public health palliative care is a term that can be used to encompass a variety of approaches that involve working with communities to improve people’s experience of death, dying and bereavement. Recently, public health palliative care approaches have gained recognition and momentum within UK health policy and palliative care services. There is general consensus… Continue reading Mapping the progress and impacts of public health approaches to palliative care: a scoping review protocol
