Bovine Serum Albulmin Protein-Templated Silver Nanocluster (BSA-Ag13): An Effective Singlet Oxygen Generator for Photodynamic Cancer Therapy
This paper reports a novel synthesis approach of bovine serum albumin (BSA) protein-templated ultrasmall (<2 nm) Ag nanocluster (NC) with strong singlet oxygen generation capacity for photodynamic therapy (PDT). An atomically precise BSA-Ag13 NC (i.e., 13 Ag atoms per cluster) is successfully synthesized for the first time by using NaOH-dissolved NaBH4 solution as the controlling reducing agent. The ubiquitous size of BSA-Ag13 NC results in unique behaviors of its photoexcited states as characterized by the ultrafast laser spectroscopy using time-correlated single photon counting... περισσότερα »
Selection of Two Optional Covalent Bonds by Electric Stimuli: Dual Catalytic Switching of Redox-Active Copper
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC03407A, Communication Yu Kamamoto, Yuya Nitta, Kazuyuki Kubo, Tsutomu Mizuta, Shoko Kume Two types of redox functionality were selected for covalent immobilization on a carbon electrode, using an electric potential as the sole stimulus. A redox-active copper catalyst transformed a terminal alkyne... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/29S31Bj via IFTTT
One-Pot Synthesis with in situ Preconcentration of Spherical Monodispersed Gold Nanoparticles using Thermoresponsive 3-(Alkyldimethylammonio)-propyl Sulfate Zwitterionic Surfactants
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC04584G, Communication Yoshitaka Takagai, Ryo Miura, Arata Endo, W L Hinze Homogeneous solutions of thermoresponsive zwitterionic 3-(alkyldimethylammonio)-propyl sulfate surfactants at elevated temperatures were employed for the synthesis of gold nanoparticles (AuNPs) by the citrate reduction method. Upon cooling at completion of... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/29RR0Zq via IFTTT
Liquid crystalline nanoparticles encapsulating cisplatin and docetaxel combination for targeted therapy of breast cancer
[image: GA?id=C6BM00376A] *Biomater. Sci.*, 2016, Advance Article *DOI*: 10.1039/C6BM00376A, Paper Raj Kumar Thapa, Ju Yeon Choi, Biki Gupta, Thiruganesh Ramasamy, Bijay Kumar Poudel, Sae Kwang Ku, Yu Seok Youn, Han Gon Choi, Chul Soon Yong, Jong Oh Kim Dual drug-loaded liquid crystalline nanoparticles for targeted therapy of metastatic breast cancer. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/29FP6Jp... περισσότερα »
Energetic Assessment of the Nonexercise Activities under Free-Living Conditions
Nonexercise activities (NAs) are common types of physical activity in daily life and critical component in energy expenditure. However, energetic assessment of NA, particularly in free-living subjects, is a technical challenge. In this study, mechanical modeling and portable device were used to evaluate five common types of NA in daily life: sit to stand, lie to sit, bowing while standing, squat, and right leg over left. A human indirect calorimeter was used to measure the activity energy expenditure of NA. Mechanical work and mechanical efficiency of NA were calculated for mechan... περισσότερα »
The Epithelial Sodium Channel and the Processes of Wound Healing
The epithelial sodium channel (ENaC) mediates passive sodium transport across the apical membranes of sodium absorbing epithelia, like the distal nephron, the intestine, and the lung airways. Additionally, the channel has been involved in the transduction of mechanical stimuli, such as hydrostatic pressure, membrane stretch, and shear stress from fluid flow. Thus, in vascular endothelium, it participates in the control of the vascular tone via its activity both as a sodium channel and as a shear stress transducer. Rather recently, ENaC has been shown to participate in the processe... περισσότερα »
Mazor touts studies showing advantage of robotic assistance in MIS spinal procedures
[image: Mazor Robotics]Mazor Robotics (NSDQ:MZOR) today released data from 2 retrospective studies of its Renaissance robotic surgical device, touting the benefits of robotic assistance and surgical guidance during minimally invasive spinal surgery procedures. The company said it plans to present the data today at the 23rd International Meeting on Advanced Spine Techniques in Washington, D.C. "The results of these retrospective and prospective studies corroborate each other's conclusions. These data validate that Renaissance is performing at the highest level and delivering the po... περισσότερα »
Micro and nanotechnologies in heart valve tissue engineering
[image: S01429612.gif] Publication date: October 2016 *Source:*Biomaterials, Volume 103 Author(s): Anwarul Hasan, John Saliba, Hassan Pezeshgi Modarres, Ahmed Bakhaty, Amir Nasajpour, Mohammad R.K. Mofrad, Amir Sanati-Nezhad Due to the increased morbidity and mortality resulting from heart valve diseases, there is a growing demand for off-the-shelf implantable tissue engineered heart valves (TEHVs). Despite the significant progress in recent years in improving the design and performance of TEHV constructs, viable and functional human implantable TEHV constructs have remained elusive.... περισσότερα »
Association between aberrant APC promoter methylation and breast cancer pathogenesis: a meta-analysis of 35 observational studies
[image: fig-1-1x.jpg] Background. Adenomatous polyposis coli (APC) is widely known as an antagonist of the Wnt signaling pathway via the inactivation of β-catenin. An increasing number of studies have reported that APC methylation contributes to the predisposition to breast cancer (BC). However, recent studies have yielded conflicting results. Methods. Herein, we systematically carried out a meta-analysis to assess the correlation between APC methylation and BC risk. Based on searches of the Cochrane Library, PubMed, Web of Science and Embase databases, the odds ratio (OR) with 95... περισσότερα »
Sunlight-assisted, biocatalytic formate synthesis from CO2 and water using silicon-based photoelectrochemical cells
[image: GA?id=C6CC04661D] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC04661D, Communication Eun Jin Son, Jong Wan Ko, Su Keun Kuk, Hyunjun Choe, Sumi Lee, Jae Hong Kim, Dong Heon Nam, Gyeong Min Ryu, Yong Hwan Kim, Chan Beum Park A silicon-based photoelectrochemical cell is developed to convert CO2 to formate with water as an electron donor by using formate dehydrogenase from *Thiobacillus* sp. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via... περισσότερα »
A simple, sufficient, and consistent method to score the status of threats and demography of imperiled species
[image: fig-1-1x.jpg] Managers of large, complex wildlife conservation programs need information on the conservation status of each of many species to help strategically allocate limited resources. Oversimplifying status data, however, runs the risk of missing information essential to strategic allocation. Conservation status consists of two components, the status of threats a species faces and the species' demographic status. Neither component alone is sufficient to characterize conservation status. Here we present a simple key for scoring threat and demographic changes for specie... περισσότερα »
Ruthenium(0)-catalyzed hydroarylation of alkynes via ketone-directed C-H functionalization using in situ-generated ruthenium complexes
[image: GA?id=C6CC04537E] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC04537E, Communication Feng Hu, Michal Szostak Ketone-directed Ru(0)-catalyzed hydroarylation of alkynes enabled by *in situ* generation of a Ru(0) catalyst from an air-stable, inexpensive and user-friendly Ru(II) precatalyst is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/29FEStU via IFTTT
Comparison of buckwheat, red clover, and purple tansy as potential surrogate plants for use in semi-field pesticide risk assessments with Bombus impatiens
[image: fig-1-1x.jpg] Background. Bumble bees (Bombus spp.) are important wild and managed pollinators. There is increased interest in incorporating data on bumble bees into risk assessments for pesticides, but standardized methods for assessing hazards of pesticides in semi-field and field settings have not yet been established for bumble bees. During semi-field studies, colonies are caged with pesticide-treated flowering surrogate plants, which must be attractive to foragers to ensure colony exposure to the test compound, and must produce an ample nectar and pollen to sustain col... περισσότερα »
Meter scale variation in shrub dominance and soil moisture structure Arctic arthropod communities
[image: fig-1-1x.jpg] The Arctic is warming at twice the rate of the rest of the world. This impacts Arctic species both directly, through increased temperatures, and indirectly, through structural changes in their habitats. Species are expected to exhibit idiosyncratic responses to structural change, which calls for detailed investigations at the species and community level. Here, we investigate how arthropod assemblages of spiders and beetles respond to variation in habitat structure at small spatial scales. We sampled transitions in shrub dominance and soil moisture between thre... περισσότερα »
Effects of agricultural fungicides on microorganisms associated with floral nectar: susceptibility assays and field experiments
Abstract Pesticides have become an inseparable element of agricultural intensification. While the direct impact of pesticides on non-target organisms, such as pollinators, has recently received much attention, less consideration has been given to the microorganisms that are associated with them. Specialist yeasts and bacteria are known to commonly inhabit floral nectar and change its chemical… Continue reading Effects of agricultural fungicides on microorganisms associated with floral nectar: susceptibility assays and field experiments
Correlation Between Histological Diagnosis and Mutational Panel Testing of Thyroid Nodules: A Two-Year Institutional Experience
Correlation Between Histological Diagnosis and Mutational Panel Testing of Thyroid Nodules: A Two-Year Institutional Experience: Thyroid , Vol. 0, No. 0. Author information Rupendra T. Shrestha,1 Maria R. Evasovich,2 Khalid Amin,3 Angela Radulescu,1 Tina S. Sanghvi,4Andrew C. Nelson,3 Maryam Shahi,3 and Lynn A. Burmeister1 1Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, University of… Continue reading Correlation Between Histological Diagnosis and Mutational Panel Testing of Thyroid Nodules: A Two-Year Institutional Experience
Effects of Covering Surgical Wounds with Polyglycolic Acid Sheets for Posttonsillectomy Pain
Effects of Covering Surgical Wounds with Polyglycolic Acid Sheets for Posttonsillectomy Pain: Postoperative pain is a remaining issue in tonsillectomy. Polyglycolic acid (PGA) is a biocompatible material used for absorbent suture reinforcement, and its sheet has been applied for covering defects after resection of oral carcinoma. The aim of this study is to examine whether… Continue reading Effects of Covering Surgical Wounds with Polyglycolic Acid Sheets for Posttonsillectomy Pain
In multiple endocrine neoplasia syndrome type 2A (MEN 2A), early total thyroidectomy (TT; performed before the age of 5 years) is the best option to prevent medullary thyroid carcinoma (MTC) development
Surgery in MEN 2A Patients Older Than 5 Years with Micro-MTC: Outcome at Long-term Follow-up: In multiple endocrine neoplasia syndrome type 2A (MEN 2A), early total thyroidectomy (TT; performed before the age of 5 years) is the best option to prevent medullary thyroid carcinoma (MTC) development, but the management of MEN 2A patients diagnosed after… Continue reading In multiple endocrine neoplasia syndrome type 2A (MEN 2A), early total thyroidectomy (TT; performed before the age of 5 years) is the best option to prevent medullary thyroid carcinoma (MTC) development
Endoscopic Endonasal Repair of Septal Perforation with Interpositional Auricular Cartilage Grafting via a Mucosal Regeneration Technique
Endoscopic Endonasal Repair of Septal Perforation with Interpositional Auricular Cartilage Grafting via a Mucosal Regeneration Technique: We evaluated the efficacy of interpositional auricular cartilage grafting for perforation with an endoscopic endonasal approach via a mucosal regeneration technique. In total, 12 patients with symptomatic septal perforations were operated on by way of an endoscopic endonasal approach… Continue reading Endoscopic Endonasal Repair of Septal Perforation with Interpositional Auricular Cartilage Grafting via a Mucosal Regeneration Technique
Milk: An epigenetic inducer of FoxP3 expression
Milk: An epigenetic inducer of FoxP3 expression: Kirchner et al1 recently implicated microRNAs of unprocessed cow’s milk in mediating the allergy-preventive effect of farm milk.2 On the basis of translational evidence, we predicted that the transmission of milk-derived immune-regulatory exosomal microRNAs including microRNA-148a, microRNA-155, microRNA-29b, and microRNA-21 prevent atopy by inducing FoxP3+ regulatory T (Treg)-cell… Continue reading Milk: An epigenetic inducer of FoxP3 expression
The Assessment of the Newborn Hearing Screening Program
in the Region of Murcia from 2004-2012: Newborn (NB) auditory deficit has a prevalence of 1-2% in the world. Since the 1990s different screening programs have been put into practice. The Newborn Hearing Screening Program has been in operation since 2002 in our hospital (HCUVA) in Murcia (Spain) and two years later it was introduced… Continue reading The Assessment of the Newborn Hearing Screening Program
Acceptance of internet-based hearing healthcare among adults who fail a hearing screening
Volume 55, Issue 9, September 2016, pages 483-490<br>10.1080/14992027.2016.1185804<br>Ann M. Rothpletz from #Audiology via xlomafota13 on Inoreader http://ift.tt/29yTmuE via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29FcP1I via IFTTT
Bladder preservation in non-metastatic muscle-invasive bladder cancer (MIBC): a single-institution experience
Marianna A Gerardi, Barbara A Jereczek-Fossa, Dario Zerini, Alessia Surgo, Samantha Dicuonzo, Ruggero Spoto, Cristiana Fodor, Elena Verri, Maria Cossu Rocca, Franco Nolè, Matteo Muto, Matteo Ferro, Gennaro Musi, Danilo Bottero, Deliu V Matei, Ottavio De Cobelli and Roberto Orecchia from Cancer via xlomafota13 on Inoreader http://ift.tt/2a0d4DL via IFTTT http://ift.tt/29JCR2i from #Med Blogs by Alexandros… Continue reading Bladder preservation in non-metastatic muscle-invasive bladder cancer (MIBC): a single-institution experience
Communicating Uncertain News in Cancer Consultations
Abstract In cancer communication, most of the literature is in the realm of delivering bad news while much less attention has been given to the communication of uncertain news around the diagnosis and the possible outcomes of the illness. Drawing on video-recorded cancer consultations collected in two Italian hospitals, this article analyzes three communication practices… Continue reading Communicating Uncertain News in Cancer Consultations
Acceptance of internet-based hearing healthcare among adults who fail a hearing screening
Volume 55, Issue 9, September 2016, pages 483-490<br>10.1080/14992027.2016.1185804<br>Ann M. Rothpletz from #Audiology via xlomafota13 on Inoreader http://ift.tt/29yTmuE via IFTTT
Acceptance of internet-based hearing healthcare among adults who fail a hearing screening
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Volume 55, Issue 9, September 2016, pages 483-490<br>10.1080/14992027.2016.1185804<br>Ann M. Rothpletz http://ift.tt/29yTmuE
Acceptance of internet-based hearing healthcare among adults who fail a hearing screening
Volume 55, Issue 9, September 2016, pages 483-490<br>10.1080/14992027.2016.1185804<br>Ann M. Rothpletz from #Audiology via xlomafota13 on Inoreader http://ift.tt/29yTmuE via IFTTT
Acceptance of internet-based hearing healthcare among adults who fail a hearing screening
Volume 55, Issue 9, September 2016, pages 483-490<br>10.1080/14992027.2016.1185804<br>Ann M. Rothpletz from #Audiology via ola Kala on Inoreader http://ift.tt/29yTmuE via IFTTT
Effective method of measuring the radioactivity of 131I-capsule prior to radioiodine therapy with significant reduction of the radiation exposure to the medical staff
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Radiation Protection in Radiology, Nuclear Medicine and Radio Oncology is of the utmost importance. Radioiodine therapy is a frequently used and effective method for the treatment of thyroid disease. Prior to each therapy the radioactivity of the [131I]-capsule must be determined to prevent misadministration. This leads to a significant radiation exposure to the staff. We […]
Automated Calculation of Water-equivalent Diameter (DW) Based on AAPM Task Group 220
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
The purpose of this study is to accurately and effectively automate the calculation of the water-equivalent diameter (DW) from 3D CT images for estimating the size-specific dose. DW is the metric that characterizes the patient size and attenuation. In this study, DW was calculated for standard CTDI phantoms and patient images. Two types of phantom […]
Energetic Assessment of the Nonexercise Activities under Free-Living Conditions
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Nonexercise activities (NAs) are common types of physical activity in daily life and critical component in energy expenditure. However, energetic assessment of NA, particularly in free-living subjects, is a technical challenge. In this study, mechanical modeling and portable device were used to evaluate five common types of NA in daily life: sit to stand, lie […]
Generalized Anxiety Disorder and Hypoglycemia Symptoms Improved with Diet Modification
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Observational evidence suggests that a relationship may exist between high glycemic index diets and the development of anxiety and depression symptoms; however, as no interventional studies assessing this relationship in a psychiatric population have been completed, the possibility of a causal link is unclear. AB is a 15-year-old female who presented with concerns of generalized […]
Paediatric Nonfunctioning Adrenocortical Carcinoma with Extension up to Right-Side Heart: Cardiac Surgery Approach
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Adrenocortical carcinoma is a rare malignancy. Due to late diagnosis and no adequate effective adjuvant treatment, prognosis remains poor. Only approximately 30% of these malignancies are confined to the adrenal gland when they are diagnosed, as these tumors tend to be found years after their genesis. Cardiac involvement of adrenal carcinoma is very rare. We […]
The Epithelial Sodium Channel and the Processes of Wound Healing
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
The epithelial sodium channel (ENaC) mediates passive sodium transport across the apical membranes of sodium absorbing epithelia, like the distal nephron, the intestine, and the lung airways. Additionally, the channel has been involved in the transduction of mechanical stimuli, such as hydrostatic pressure, membrane stretch, and shear stress from fluid flow. Thus, in vascular endothelium, […]
A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Introduction. We evaluated the effects of a therapy that combines myo-inositol (MI) and D-chiro-inositol (DCI) in young overweight women affected by polycystic ovary syndrome (PCOS), characterized by oligo- or anovulation and hyperandrogenism, correlated to insulin resistance. Methods. We enrolled 46 patients affected by PCOS and, randomly, we assigned them to two groups, A and B, […]
A Review on Properties, Opportunities, and Challenges of Transformer Oil-Based Nanofluids
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
The mineral oil or synthetic oil in conjunction with paper is mainly being applied as dielectric medium in many of the high voltage apparatus. However, the advent of high voltage levels such high voltage alternating current (HVAC) and high voltage direct current (HVDC) has prompted researchers to direct their focus onto an insulation system which […]
A Parasitic Array Receiver for ISAR Imaging of Ship Targets Using a Coastal Radar
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
The detection and identification of ship targets navigating in coastal areas are essential in order to prevent maritime accidents and to take countermeasures against illegal activities. Usually, coastal radar systems are employed for the detection of vessels, whereas noncooperative ship targets as well as ships not equipped with AIS transponders can be identified by means […]
The Use of Xpert MTB/Rif for Active Case Finding among TB Contacts in North West Province, South Africa
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Introduction. Tuberculosis is a major cause of morbidity and mortality especially in high HIV burden settings. Active case finding is one strategy to potentially reduce TB disease burden. Xpert MTB/Rif has recently been recommended for diagnosis of TB. Methods. Pragmatic randomized trial to compare diagnosis rate and turnaround time for laboratory testing for Xpert MTB/Rif […]
Descending Projections from the Inferior Colliculus to Medial Olivocochlear Efferents
: Mice with Normal Hearing, Early Onset Hearing Loss, and Congenital Deafness via Hearing Research [image: S03785955.gif] Publication date: Available online 12 July 2016 *Source:*Hearing Research Author(s): Kirupa Suthakar, David K. Ryugo Auditory efferent neurons reside in the brain and innervate the sensory hair cells of the cochlea to modulate incoming acoustic signals. Two groups of efferents have been described in mouse and this report will focus on the medial olivocochlear (MOC) system. Electrophysiological data suggest the MOC efferents function in selective listening by di... περισσότερα »
Descending Projections from the Inferior Colliculus to Medial Olivocochlear Efferents
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
: Mice with Normal Hearing, Early Onset Hearing Loss, and Congenital Deafness via Hearing Research Publication date: Available online 12 July 2016Source:Hearing ResearchAuthor(s): Kirupa Suthakar, David K. RyugoAuditory efferent neurons reside in the brain and innervate the sensory hair cells of the cochlea to modulate incoming acoustic signals. Two groups of efferents have been described in […]
Granulomatosis with Polyangiitis with Bilateral Facial Palsy and Severe Mixed Hearing Loss
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Granulomatosis with Polyangiitis with Bilateral Facial Palsy and Severe Mixed Hearing Loss: Granulomatosis with polyangiitis is autoimmune and rare disease. It affects many organs, but the most often affected organs are the nose, lungs, and kidneys. It is part of vasculitis and causes an autoimmune attack by an abnormal type of circulating antibody termed ANCAs […]
Investigation into the presence of human papillomavirus in patients with obstructive sleep apnea
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Investigation into the presence of human papillomavirus in patients with obstructive sleep apnea: Objectives/Hypothesis The human papillomavirus (HPV) is known to infect the tissues of the oropharynx as demonstrated in HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). HPV has also been shown to induce benign lymphoid hypertrophy. We sought to investigate an association between obstructive sleep […]
Safety and postoperative adverse events in pediatric airway reconstruction: Analysis of ACS-NSQIP-P 30-day outcomes
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Safety and postoperative adverse events in pediatric airway reconstruction: Analysis of ACS-NSQIP-P 30-day outcomes: Objectives Prior research has shown that airway reconstructive procedures comprise significant composite morbidity compared to the whole of pediatric otolaryngologic cases evaluated in the American College of Surgeon’s National Surgery Quality Improvement Program-Pediatric (ACS-NSQIP-P) platform. We describe postoperative sequelae of pediatric […]
Open Tracheostomy Procedure,Percutaneous Dilatational Tracheostomy,Focused Assessment with Sonography for Trauma,Central Venous Access Techniques,Intracranial Pressure Monitors,Tube Thoracostomy,Radial and Femoral Artery Catheterization Techniques,Percutaneous Endoscopic Gastrostomy and Open Gastrostomy,Lumbar Puncture Technique and Lumbar Drains,Percutaneous Bladder Catheterization (Suprapubic Bladder Catheterization).
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Open Tracheostomy Procedure Review Article Pages 117-124 Christine B. Taylor, Randal A. Otto First page PDF Purchase PDF – $31.50 Supplementary content Keywords Tracheostomy; Tracheotomy; Surgical airway; Emergent airway; Tracheostomy care;Tracheostomy complications First page preview Not entitled to full text Percutaneous Dilatational Tracheostomy Review ArticlePages 125-129Lillian F. Liao, John G. Myers First page PDF Purchase PDF – $31.50 […]
Surgically Assisted Maxillary Expansion
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Atlas of the Oral and Maxillofacial Surgery Clinics Volume 24, Issue 1, Techniques in Orthognathic Surgery Norman J. Betts, DDS, MSa, b, c, , a Private Practice, Chelsea Oral and Facial Surgery, 1303 South Main Street, Suite B, Chelsea, MI 48118, USA b Private Practice, Ann Arbor Oral and Facial Surgery, 3055 Plymouth Road, Suite 202, Ann Arbor, MI 48105, USA […]
Genioplasty
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Atlas of the Oral and Maxillofacial Surgery Clinics Volume 24, Issue 1, Techniques in Orthognathic Surgery Carlo Ferretti, BDS, MDent (MFOS), FCD (SA) MFOSa, , , Johan P. Reyneke, BChD, MChD, FCMOS (SA), PhDb, c, d, e Show more Genioplasty; Chin deformity; Genioplasty technique First page preview Keywords Key points Introduction Surgical technique References Figures and tables http://ift.tt/29RUA5S
Concomitant Temporomandibular Joint Custom-Fitted Total Joint Reconstruction and Orthognathic Surgery
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Atlas of the Oral and Maxillofacial Surgery Clinics Volume 24, Issue 1, March 2016, Pages 55–66 Techniques in Orthognathic Surgery Computer-Assisted Surgical Simulation for Larry M. Wolford, DMDa, b, , a Departments of Oral and Maxillofacial Surgery and Orthodontics, Texas A&M University Health Science Center, Baylor College of Dentistry, Dallas, TX, USA b Private Practice, Baylor University Medical Center, Dallas, […]
Simultaneous Maxillary and Mandibular Orthognathic Surgery
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Implications of Sequencing in Simultaneous Maxillary and Mandibular Orthognathic Surgery Review Article Pages 45-53 Daniel Perez, Edward Ellis III First page PDF Purchase PDF – $31.50 Keywords Bimaxillary surgery; Le Fort osteotomy; Bilateral sagittal split osteotomy; Surgical sequence in orthognathic surgery; Mandible first First page preview Keywords Key points The case for mandibular surgery first […]
Endoscopic ultrasound guided transoral drainage of parapharyngeal abscess
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
from #Esophageal Cancer via a.lsfakia on Inoreader http://ift.tt/2ac1lyg via IFTTT http://ift.tt/29yS3f0
Caprini Scores, Risk Stratification, and Rivaroxaban in Plastic Surgery: Time to Reconsider Our Strategy
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
[image: image]Summary: Limited data are available regarding the pathophysiology of venous thromboembolism in plastic surgery patients. In an effort to identify patients at greater risk, some investigators promote individual risk assessment using Caprini scores. However, these scores do not correlate with relative risk values. Affected patients cannot be reliably predicted (97% false positive rate). Caprini scores make many body contouring patients candidates for chemoprophylaxis, an intervention that introduces risks related to anticoagulation. Caprini has financial conflicts with s... περισσότερα »
Salvaging the Infected Breast Tissue Expander: A Standardized Multidisciplinary Approach
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
[image: image]Background: Infections of breast tissue expander (TE) are complex, often requiring TE removal and hospitalization, which can delay further adjuvant therapy and add to the overall costs of breast reconstruction. Therefore, to reduce the rate of TE removal, hospitalization, and costs, we created a standardized same-day multidisciplinary outpatient quality improvement protocol for diagnosing and treating patients with early signs of TE infection. Methods: We prospectively evaluated 26 consecutive patients who developed a surgical site infection between February 2013 and A... περισσότερα »
Surgical Delay of the Nipple–Areolar Complex in High-risk Nipple-sparing Mastectomy Reconstruction
Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
[image: image]Summary: As nipple-sparing mastectomy gains increasing popularity, minimizing the risk of nipple necrosis continues to be of critical importance to patients and surgeons. Patients with large or ptotic breasts, scars from previous cosmetic and/or oncologic breast surgery, or previous irradiation have often been denied nipple-sparing mastectomy (NSM) because of increased risk of nipple necrosis. A variety of interventions have been suggested to minimize the ischemic insult to the nipple–areolar complex (NAC). This article presents our experience in 26 high-risk patients ... περισσότερα »
Influence of the natural Rio Negro water on the toxicological effects of a crude oil and its chemical dispersion to the Amazonian fish Colossoma macropomum
Abstract The increment in crude oil exploitation over the last decades has considerably increased the risk of polycyclic aromatic hydrocarbon (PAH) contamination to Amazonian aquatic environments, especially for the black water environments such as the Rio Negro. The present work was designed to evaluate the acute toxicity of the Urucu crude oil (CO), the chemically dispersed Urucu crude oil (CO + D), and the dispersant alone (D) to the Amazonian fish *Colossoma macropomum*. Acute toxicity tests were performed, using a more realistic approach, where fish were acclimated to both gr... περισσότερα »
Effects of agricultural fungicides on microorganisms associated with floral nectar: susceptibility assays and field experiments
Abstract Pesticides have become an inseparable element of agricultural intensification. While the direct impact of pesticides on non-target organisms, such as pollinators, has recently received much attention, less consideration has been given to the microorganisms that are associated with them. Specialist yeasts and bacteria are known to commonly inhabit floral nectar and change its chemical characteristics in numerous ways, possibly influencing pollinator attraction. In this study, we investigated the in vitro susceptibility of nectar yeasts *Metschnikowia gruessi*, *Metschnikowi... περισσότερα »
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
New England Journal of Medicine, Ahead of Print. http://ift.tt/29QfoMe
Ions switch off darkness: Role of TPC2 in melanosomes
Melanins are naturally occurring pigments that color the eye, skin and hair of mammals, thereby protecting the body from harmful solar radiation that can lead to skin cancers. Melanins are synthesized and stored within specialized organelles called melanosomes, which are generated within epidermal and uveal melanocytes as well as retinal pigment epithelium. Packaging melanins into pigment granules relies on the proper localization and activity of melanosomal components. To date, hundreds of genes and associated products have been identified as key regulators of pigmentation. Amon... περισσότερα »
Incontinentia Pigmenti with Persistent Hypercalcemia: Case Report
Abstract Incontinentia pigmenti (IP) is an X-linked dominant disorder that in most cases is considered lethal in males. IP affects the skin, hair, teeth, nails, eyes, and central nervous system. We report a case of persistent hypercalcemia (10.6–11.3 mg/dL) in a 19-month-old Caucasian boy with clinical IP. The proposed mechanism for his hypercalcemia is discussed. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/29FxEWy via IFTTT
Progression of Idiopathic Eruptive Macular Pigmentation in a Girl from Childhood to Adolescence: Case Report and Literature Review
Abstract A 14-year-old girl developed brownish round macules and patches over the face, trunk, and proximal limbs with extensive progression since she was 7 years old. Electron microscopy examination revealed an increase in the number and maturity of melanosomes in basal and suprabasal keratinocytes, although the number of melanocytes was within the normal range. A diagnosis of idiopathic eruptive macular pigmentation was made. We describe the unusual disease progression of this case of idiopathic eruptive macular pigmentation, which was thought to be self-limited. from #Dermatol... περισσότερα »
Presence of gonadotropin-releasing hormone-like peptide in the central nervous system and reproductive organs of the male blue swimming crab, Portunus pelagicus , and its effect on spermatogenesis
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Abstract Our previous studies have demonstrated that lamprey gonadotropin-releasing hormone-III (lGnRH-III)-like peptide occurs in the central nervous system (CNS) of decapod crustaceans (*Macrobrachium rosenbergii*, *Penaeus monodon*, *Portunus pelagicus*), and that lGnRH-III is the most potent in stimulating ovarian maturation compared with other GnRH isoforms. In this study, we examined the localization of lGnRH-III-like peptide in the CNS and male reproductive organs of the blue swimming crab by using anti-lGnRH-III as a probe. In the brain, lGnRH-III immunoreactivity (−ir) was... περισσότερα »
Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Abstract Growth/differentiation factor−15 (Gdf-15) is a member of the transforming growth factor-β (Tgf-β) superfamily and has been shown to be a potent neurotrophic factor for midbrain dopaminergic (DAergic) neurons both in vitro and in vivo. Gdf-15 has also been shown to be involved in inflammatory processes. The aim of this study was to identify the role of endogenous Gdf-15 in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease (PD) by comparing *Gdf-15* +/+ and *Gdf-15* −/− mice. At 4 days and 14 days post-MPTP administration, both *Gdf-... περισσότερα »
Connexin 50 modulates Sox2 expression in spinal-cord-derived ependymal stem/progenitor cells
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Abstract Ion channels included in the family of Connexins (Cx) have been reported to influence the secondary expansion of traumatic spinal cord injury (SCI) and neuropathic pain following SCI. However, Cxs also contribute to spinal cord neurogenesis during the remyelinating process and functional recovery after SCI. Certain Cxs have been recently related to the control of cell proliferation and the differentiation of neuronal progenitors. Adult spinal-cord-derived ependymal stem progenitor cells (epSPC) show high expression levels of Cx50 in non-pathological conditions and lower e... περισσότερα »
Syndecans in heart fibrosis
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Abstract Heart disease is a deadly syndrome affecting millions worldwide. It reflects an unmet clinical need, and the disease mechanisms are poorly understood. Cardiac fibrosis is central to heart disease. The four-membered family of transmembrane proteoglycans, syndecan-1 to -4, is believed to regulate fibrosis. We review the current literature concerning syndecans in cardiac fibrosis. Syndecan expression is up-regulated in response to pro-inflammatory stimuli in various forms of heart disease with fibrosis. Mice lacking syndecan-1 and −4 show reduced activation of pro-fibrotic s... περισσότερα »
Mass-Forming Venous Malformation of the Caecum
from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/29LbqEq via IFTTT
Acceptance of internet-based hearing healthcare among adults who fail a hearing screening
Volume 55, Issue 9, September 2016, pages 483-490<br>10.1080/14992027.2016.1185804<br>Ann M. Rothpletz from #ENT via xlomafota13 on Inoreader http://ift.tt/29yTmuE via IFTTT
Bladder preservation in non-metastatic muscle-invasive bladder cancer (MIBC): a single-institution experience
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 17 δευτερόλεπτα
Marianna A Gerardi, Barbara A Jereczek-Fossa, Dario Zerini, Alessia Surgo, Samantha Dicuonzo, Ruggero Spoto, Cristiana Fodor, Elena Verri, Maria Cossu Rocca, Franco Nolè, Matteo Muto, Matteo Ferro, Gennaro Musi, Danilo Bottero, Deliu V Matei, Ottavio De Cobelli and Roberto Orecchia from Cancer via xlomafota13 on Inoreader http://ift.tt/2a0d4DL via IFTTT http://ift.tt/29JCR2i
Communicating Uncertain News in Cancer Consultations
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 17 δευτερόλεπτα
Abstract In cancer communication, most of the literature is in the realm of delivering bad news while much less attention has been given to the communication of uncertain news around the diagnosis and the possible outcomes of the illness. Drawing on video-recorded cancer consultations collected in two Italian hospitals, this article analyzes three communication practices used by oncologists to interactionally manage the uncertainty during the visit: alternating between uncertain bad news and certain good news, anticipating scenarios, and guessing test results. Both diagnostic and ... περισσότερα »
Imbalance of endogenous prostanoids in moderate-to-severe asthma
Publication date: Available online 12 July 2016 *Source:*Allergology International Author(s): Masaya Takemura, Akio Niimi, Hisako Matsumoto, Tetsuya Ueda, Masafumi Yamaguchi, Hirofumi Matsuoka, Makiko Jinnai, Kian Fan Chung, Michiaki Mishima BackgroundInhalation studies suggested "protective" roles of exogenous prostaglandin E2, but the clinical relevance of endogenous prostanoids in asthma is poorly known. The objective of this study is to measure sputum levels of prostanoids in asthmatic patients to correlate with clinical indices.MethodsMild (n = 41) or moderate-to-severe (19) as... περισσότερα »
The safety of intranasal steroids during pregnancy: A good start
[image: 1-s2.0-S0091674916X00061-cov150h.gif] Publication date: July 2016 *Source:*Journal of Allergy and Clinical Immunology, Volume 138, Issue 1 Author(s): Jennifer A. Namazy, Michael Schatz from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29RPLti
Rapid Molecular Diagnostics of Severe Primary Immunodeficiency by Targeted Next Generation Sequencing
Publication date: Available online 12 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Hui Yu, Victor Wei Zhang, Asbjørg Stray-Pedersen, Imelda Celine Hanson, Lisa R. Forbes, M. Teresa de la Morena, Ivan K. Chinn, Elizabeth Gorman, Nancy J. Mendelsohn, Tamara Pozos, Wojciech Wiszniewski, Sarah K. Nicholas, Anne B. Yates, Lindsey E. Moore, Knut Erik Berge, Hanne Sorte, Diana K. Bayer, Daifulah ALZahrani, Raif S. Geha, Yanming Feng, Guoli Wang, Jordan S. Orange, James R. Lupski, Jing Wang, Lee-Jun Wong BackgroundPrimary immunodeficiency diseases (PIDD) are inher... περισσότερα »
Reply
[image: alertIcon.gif] Publication date: Available online 12 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Markus J. Ege, Michael W. Pfaffl from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29S0YwQ
Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1
Publication date: July 2016 *Source:*Journal of Allergy and Clinical Immunology, Volume 138, Issue 1 Author(s): Timothy S.C. Hinks, Tom Brown, Laurie C.K. Lau, Hitasha Rupani, Clair Barber, Scott Elliott, Jon A. Ward, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Ratko Djukanović, Ramesh J. Kurukulaaratchy, Anoop Chauhan, Peter H. Howarth BackgroundDisease heterogeneity in patients with severe asthma and its relationship to inflammatory mechanisms remain poorly understood.ObjectiveWe aimed to identify and replicate clinicopathologic endotypes based on analysis of blood and sputum parame... περισσότερα »
Milk: An epigenetic inducer of FoxP3 expression
[image: alertIcon.gif] Publication date: Available online 12 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Bodo C. Melnik, Swen Malte John, Gerd Schmitz from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29S0UwZ
Successful hematopoietic stem cell transplantation for myelofibrosis in an adult with Warts-Hypogammaglobulinemia-Immunodeficiency-Myelokathexis syndrome
[image: alertIcon.gif] Publication date: Available online 12 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Leen Moens, Glynis Frans, Barbara Bosch, Xavier Bossuyt, Bert Verbinnen, Willy Poppe, Nancy Boeckx, Mary Slatter, Caroline Brusselmans, George Diaz, Thomas Tousseyn, Helena Flipts, Anniek Corveleyn, Daan Dierickx, Isabelle Meyts Teaser Capsule Summary: Myelofibrosis can develop in patients with WHIM syndrome – hematopoietic stem cell transplantation is curative. from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29RPxCr
Cover 1
[image: alertIcon.gif] Publication date: July 2016 *Source:*Journal of Allergy and Clinical Immunology, Volume 138, Issue 1 from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29S12Nm
Brief Overview of This Month's JACI
[image: alertIcon.gif] Publication date: July 2016 *Source:*Journal of Allergy and Clinical Immunology, Volume 138, Issue 1 from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29RPFlv
Table of Contents
Publication date: July 2016 *Source:*Journal of Allergy and Clinical Immunology, Volume 138, Issue 1 from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29S0GpZ
The Editors' Choice
[image: alertIcon.gif] Publication date: July 2016 *Source:*Journal of Allergy and Clinical Immunology, Volume 138, Issue 1 Author(s): Cezmi A. Akdis, Zuhair K. Ballas from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29RPBlC
Editorial Board
[image: alertIcon.gif] Publication date: July 2016 *Source:*Journal of Allergy and Clinical Immunology, Volume 138, Issue 1 from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29S1088
Information for Readers
[image: alertIcon.gif] Publication date: July 2016 *Source:*Journal of Allergy and Clinical Immunology, Volume 138, Issue 1 from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29RPxTc
Second Herbert Fleisch Workshop, 2016
IBMS BoneKEy 13 doi: 10.1038/bonekey.2016.51 from Environmental Medicine via xlomafota13 on Inoreader http://ift.tt/29ZXEj1 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29GyHqC via IFTTT
Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation
The cytokines interleukin-11 (IL-11) and IL-6 are important proteins with well-defined pro- and anti-inflammatory functions. They activate intracellular signaling cascades through a homodimer of the ubiquitously expressed signal-transducing β-receptor glycoprotein 130 (gp130). Specificity is gained through the cell- and tissue-specific expression of the nonsignaling IL-11 and IL-6 α-receptors (IL-11R and IL-6R), which determine the responsiveness of the cell to these two cytokines. IL-6 is a rare example, where its soluble receptor (sIL-6R) has agonistic properties, so that the IL... περισσότερα »
Liquid crystalline nanoparticles encapsulating cisplatin and docetaxel combination for targeted therapy of breast cancer
[image: GA?id=C6BM00376A] *Biomater. Sci.*, 2016, Advance Article *DOI*: 10.1039/C6BM00376A, Paper Raj Kumar Thapa, Ju Yeon Choi, Biki Gupta, Thiruganesh Ramasamy, Bijay Kumar Poudel, Sae Kwang Ku, Yu Seok Youn, Han Gon Choi, Chul Soon Yong, Jong Oh Kim Dual drug-loaded liquid crystalline nanoparticles for targeted therapy of metastatic breast cancer. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/29FP6Jp... περισσότερα »
Energetic Assessment of the Nonexercise Activities under Free-Living Conditions
Nonexercise activities (NAs) are common types of physical activity in daily life and critical component in energy expenditure. However, energetic assessment of NA, particularly in free-living subjects, is a technical challenge. In this study, mechanical modeling and portable device were used to evaluate five common types of NA in daily life: sit to stand, lie to sit, bowing while standing, squat, and right leg over left. A human indirect calorimeter was used to measure the activity energy expenditure of NA. Mechanical work and mechanical efficiency of NA were calculated for mechan... περισσότερα »
The Epithelial Sodium Channel and the Processes of Wound Healing
The epithelial sodium channel (ENaC) mediates passive sodium transport across the apical membranes of sodium absorbing epithelia, like the distal nephron, the intestine, and the lung airways. Additionally, the channel has been involved in the transduction of mechanical stimuli, such as hydrostatic pressure, membrane stretch, and shear stress from fluid flow. Thus, in vascular endothelium, it participates in the control of the vascular tone via its activity both as a sodium channel and as a shear stress transducer. Rather recently, ENaC has been shown to participate in the processe... περισσότερα »
Mazor touts studies showing advantage of robotic assistance in MIS spinal procedures
[image: Mazor Robotics]Mazor Robotics (NSDQ:MZOR) today released data from 2 retrospective studies of its Renaissance robotic surgical device, touting the benefits of robotic assistance and surgical guidance during minimally invasive spinal surgery procedures. The company said it plans to present the data today at the 23rd International Meeting on Advanced Spine Techniques in Washington, D.C. "The results of these retrospective and prospective studies corroborate each other's conclusions. These data validate that Renaissance is performing at the highest level and delivering the po... περισσότερα »
Micro and nanotechnologies in heart valve tissue engineering
[image: S01429612.gif] Publication date: October 2016 *Source:*Biomaterials, Volume 103 Author(s): Anwarul Hasan, John Saliba, Hassan Pezeshgi Modarres, Ahmed Bakhaty, Amir Nasajpour, Mohammad R.K. Mofrad, Amir Sanati-Nezhad Due to the increased morbidity and mortality resulting from heart valve diseases, there is a growing demand for off-the-shelf implantable tissue engineered heart valves (TEHVs). Despite the significant progress in recent years in improving the design and performance of TEHV constructs, viable and functional human implantable TEHV constructs have remained elusive.... περισσότερα »
Association between aberrant APC promoter methylation and breast cancer pathogenesis: a meta-analysis of 35 observational studies
[image: fig-1-1x.jpg] Background. Adenomatous polyposis coli (APC) is widely known as an antagonist of the Wnt signaling pathway via the inactivation of β-catenin. An increasing number of studies have reported that APC methylation contributes to the predisposition to breast cancer (BC). However, recent studies have yielded conflicting results. Methods. Herein, we systematically carried out a meta-analysis to assess the correlation between APC methylation and BC risk. Based on searches of the Cochrane Library, PubMed, Web of Science and Embase databases, the odds ratio (OR) with 95... περισσότερα »
Sunlight-assisted, biocatalytic formate synthesis from CO2 and water using silicon-based photoelectrochemical cells
[image: GA?id=C6CC04661D] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC04661D, Communication Eun Jin Son, Jong Wan Ko, Su Keun Kuk, Hyunjun Choe, Sumi Lee, Jae Hong Kim, Dong Heon Nam, Gyeong Min Ryu, Yong Hwan Kim, Chan Beum Park A silicon-based photoelectrochemical cell is developed to convert CO2 to formate with water as an electron donor by using formate dehydrogenase from *Thiobacillus* sp. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry [image: 2abQODf] from ... περισσότερα »
A simple, sufficient, and consistent method to score the status of threats and demography of imperiled species
[image: fig-1-1x.jpg] Managers of large, complex wildlife conservation programs need information on the conservation status of each of many species to help strategically allocate limited resources. Oversimplifying status data, however, runs the risk of missing information essential to strategic allocation. Conservation status consists of two components, the status of threats a species faces and the species' demographic status. Neither component alone is sufficient to characterize conservation status. Here we present a simple key for scoring threat and demographic changes for specie... περισσότερα »
Ruthenium(0)-catalyzed hydroarylation of alkynes via ketone-directed C-H functionalization using in situ-generated ruthenium complexes
[image: GA?id=C6CC04537E] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC04537E, Communication Feng Hu, Michal Szostak Ketone-directed Ru(0)-catalyzed hydroarylation of alkynes enabled by *in situ* generation of a Ru(0) catalyst from an air-stable, inexpensive and user-friendly Ru(II) precatalyst is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry [image: 29GtBe6] from BioChemistry via xlomafota13 on Inoreader http://ift.tt/29FEStU via IFTTT from #Med Blogs ... περισσότερα »
Comparison of buckwheat, red clover, and purple tansy as potential surrogate plants for use in semi-field pesticide risk assessments with Bombus impatiens
[image: fig-1-1x.jpg] Background. Bumble bees (Bombus spp.) are important wild and managed pollinators. There is increased interest in incorporating data on bumble bees into risk assessments for pesticides, but standardized methods for assessing hazards of pesticides in semi-field and field settings have not yet been established for bumble bees. During semi-field studies, colonies are caged with pesticide-treated flowering surrogate plants, which must be attractive to foragers to ensure colony exposure to the test compound, and must produce an ample nectar and pollen to sustain col... περισσότερα »
Meter scale variation in shrub dominance and soil moisture structure Arctic arthropod communities
[image: fig-1-1x.jpg] The Arctic is warming at twice the rate of the rest of the world. This impacts Arctic species both directly, through increased temperatures, and indirectly, through structural changes in their habitats. Species are expected to exhibit idiosyncratic responses to structural change, which calls for detailed investigations at the species and community level. Here, we investigate how arthropod assemblages of spiders and beetles respond to variation in habitat structure at small spatial scales. We sampled transitions in shrub dominance and soil moisture between thre... περισσότερα »
Human population and socioeconomic modulators of conservation performance in 788 Amazonian and Atlantic Forest reserves
[image: fig-1-1x.jpg] Protected areas form a quintessential component of the global strategy to perpetuate tropical biodiversity within relatively undisturbed wildlands, but they are becoming increasingly isolated by rapid agricultural encroachment. Here we consider a network of 788 forest protected areas (PAs) in the world's largest tropical country to examine the degree to which they remain intact, and their responses to multiple biophysical and socioeconomic variables potentially affecting natural habitat loss under varying contexts of rural development. PAs within the complex B... περισσότερα »
The emerging roles of Jab1/CSN5 in cancer
Abstract C-Jun activation domain-binding protein-1 (Jab1) not only is full but also a subunit (CSN5) of the constitutive photomorphogenesis 9 signalosome (CSN), which is an evolutionarily conserved and multifunctional protein that involves in controlling cellular proliferation and apoptosis, affecting a series of pathways, as well as regulating genomic instability and DNA damage and repair. The CSN is a highly conservative protein from yeast to human and interacts with the cullin-RING family of ubiquitin ligases so that it could be execute a process of removing NEDD8, a ubiquitin-... περισσότερα »
Descending Projections from the Inferior Colliculus to Medial Olivocochlear Efferents: Mice with Normal Hearing, Early Onset Hearing Loss, and Congenital Deafness
[image: S03785955.gif] Publication date: Available online 12 July 2016 *Source:*Hearing Research Author(s): Kirupa Suthakar, David K. Ryugo Auditory efferent neurons reside in the brain and innervate the sensory hair cells of the cochlea to modulate incoming acoustic signals. Two groups of efferents have been described in mouse and this report will focus on the medial olivocochlear (MOC) system. Electrophysiological data suggest the MOC efferents function in selective listening by differentially attenuating auditory nerve fiber activity in quiet and noisy conditions. Because speech ... περισσότερα »
Descending Projections from the Inferior Colliculus to Medial Olivocochlear Efferents: Mice with Normal Hearing, Early Onset Hearing Loss, and Congenital Deafness
[image: S03785955.gif] Publication date: Available online 12 July 2016 *Source:*Hearing Research Author(s): Kirupa Suthakar, David K. Ryugo Auditory efferent neurons reside in the brain and innervate the sensory hair cells of the cochlea to modulate incoming acoustic signals. Two groups of efferents have been described in mouse and this report will focus on the medial olivocochlear (MOC) system. Electrophysiological data suggest the MOC efferents function in selective listening by differentially attenuating auditory nerve fiber activity in quiet and noisy conditions. Because speech ... περισσότερα »
In Reply
Publication date: Available online 9 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Beomjune Kim, Arshad Kaleem, Waleed Zaid from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/29UsW7P via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29yMzRy via IFTTT
Quantifying the Effect of TMJ Intra-articular Steroid Injection on Synovial Enhancement in Juvenile Idiopathic Arthritis
Publication date: Available online 5 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Cory M. Resnick, Pouya M. Vakilian, Leonard B. Kaban, Zachary S. Peacock PurposeTo quantify the effect of intra-articular steroid injections (IASI) on temporomandibular joint (TMJ) synovitis in children with juvenile idiopathic arthritis (JIA) using gadolinium enhanced magnetic resonance imaging (MRI).MethodsThis is a retrospective study of children with JIA who underwent TMJ IASIs at Boston Children's Hospital. Patients were included if they had contrast-enhanced MRIs both p... περισσότερα »
Circulating (CD3−CD19+CD20−IgD−CD27highCD38high) Plasmablasts: A Promising Cellular Biomarker for Immune Activity for Anti-PLA2R1 Related Membranous Nephropathy?
Membranous nephropathy (MN) is a kidney specific autoimmune disease mainly mediated by anti-phospholipase A2 receptor 1 autoantibody (PLA2R1 Ab). The adequate assessment of chimeric anti-CD20 monoclonal antibody, rituximab (RTX), efficacy is still needed to improve clinical outcome of patient with MN. We evaluated the modification of plasmablasts (CD3−CD19+CD20−IgD−), a useful biomarker of RTX response in other autoimmune diseases, and memory (CD3−CD19+CD20+IgD−CD27+CD38−) and naive (CD3−CD19+CD20+IgD+CD27−) B cells by fluorescence-activated cell sorter analysis in PLA2R1 related MN ... περισσότερα »
Inflammation Thread Runs across Medical Laboratory Specialities
We work on the assumption that four major specialities or sectors of medical laboratory assays, comprising clinical chemistry, haematology, immunology, and microbiology, embraced by genome sequencing techniques, are routinely in use. Medical laboratory markers for inflammation serve as model: they are allotted to most fields of medical lab assays including genomics. Incessant coding of assays aligns each of them in the long lists of big data. As exemplified with the complement gene family, containing C2, C3, C8A, C8B, CFH, CFI, and ITGB2, heritability patterns/risk factors associate... περισσότερα »
Second Herbert Fleisch Workshop, 2016
IBMS BoneKEy 13 doi: 10.1038/bonekey.2016.51 from Environmental Medicine via xlomafota13 on Inoreader http://ift.tt/29ZXEj1
Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation
The cytokines interleukin-11 (IL-11) and IL-6 are important proteins with well-defined pro- and anti-inflammatory functions. They activate intracellular signaling cascades through a homodimer of the ubiquitously expressed signal-transducing β-receptor glycoprotein 130 (gp130). Specificity is gained through the cell- and tissue-specific expression of the nonsignaling IL-11 and IL-6 α-receptors (IL-11R and IL-6R), which determine the responsiveness of the cell to these two cytokines. IL-6 is a rare example, where its soluble receptor (sIL-6R) has agonistic properties, so that the IL-6... περισσότερα »
Nocardia asteroides-Induced movement abnormalities in mice: Relevance for Parkinson’s disease?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29FGGlb via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Editorial Board
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics, Volume 1864, Issue 9 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29FP4Bl via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
RT @ecancer_patient : Recognise the symptoms for bowel cancer in younger patients: https://t.co/fwyf5vJkcl https://t.co/bzkqcdzxqu
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
RT @ecancer_patient : Recognise the symptoms for bowel cancer in younger patients: https://t.co/fwyf5vJkcl https://t.co/bzkqcdzxqu from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/753520186175676416 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Read the lessons from African countries who developed national palliative care policies under financial pressure: https://t.co/YRQspjhLiy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Read the lessons from African countries who developed national palliative care policies under financial pressure: https://t.co/YRQspjhLiy from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/753519428663377920 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
One day left to submit your application to the @uicc YY Fellowships https://t.co/ZYCVGBhfXb https://t.co/1qA41Z94wz
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
One day left to submit your application to the @uicc YY Fellowships https://t.co/ZYCVGBhfXb https://t.co/1qA41Z94wz from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/753509414250971136 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
PET/MRI: A one-stop imaging test to detect prostate cancer?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
A University of Michigan study published in The Journal of Nuclear Medicine reports that the addition of molecular imaging based on F-18-choline positron emission tomography (PET) improves the identification of significant prostate cancer over… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29JukfL via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Deciphering the mutations behind drug resistance
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Antimicrobial resistance in disease-causing microbes has garnered attention in recent years, but another persistent area of drug resistance is the ability for tumours to evade chemotherapy drugs. Methotrexate is one of the oldest chemotherapy agents, and… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29FMDPl via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & […]
A ‘key’ to metastasis formation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Researchers at Hokkaido University in Japan have demonstrated that a molecule, called biglycan, plays an intrinsic role in attracting tumour cells toward the inner wall of tumour blood vessels. Biglycan is a normal component of the supportive matrix… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29JueVo via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel […]
Recent advances in site specific conjugations of antibody drug conjugates
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Antibody-drug conjugates take the advantage of antigen specificity of monoclonal antibodies to deliver highly potent cytotoxic drugs selectively to antigen-expressing tumour cells. The recent approval of Adcetris and Kadcyla as well as emerging data… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29FMsDw via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Internal radiation therapy for better response in mCRC
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Patients with metastatic colorectal cancer with greater baseline liver tumour burden (≥12%), who were treated with the combination of mFOLFOX6 and selective internal radiation therapy SIR-Spheres Y-90 resin treatment, experience a statistically… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29Jufsu via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Endoscopic ultrasound guided transoral drainage of parapharyngeal abscess
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Mass-Forming Venous Malformation of the Caecum
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Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer’s disease
Abstract Sporadic Alzheimer's disease (AD) is characterised by the deposition and accumulation of specific protein aggregates. Failure of clearance could underlie this process, and recent genetic association studies point towards involvement of the phagocytosis and autophagy pathways. We developed a real-time tri-color flow cytometry method to quantitate the phagocytic function of human peripheral blood monocyte subsets including non-classic CD14dimCD16+, intermediate CD14+CD16+ and classic CD14+CD16− monocytes. Using this method, we have measured the phagocytic ability of fresh m... περισσότερα »
In Reply
Publication date: Available online 9 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Beomjune Kim, Arshad Kaleem, Waleed Zaid http://ift.tt/29UsW7P
Quantifying the Effect of TMJ Intra-articular Steroid Injection on Synovial Enhancement in Juvenile Idiopathic Arthritis
Publication date: Available online 5 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Cory M. Resnick, Pouya M. Vakilian, Leonard B. Kaban, Zachary S. Peacock PurposeTo quantify the effect of intra-articular steroid injections (IASI) on temporomandibular joint (TMJ) synovitis in children with juvenile idiopathic arthritis (JIA) using gadolinium enhanced magnetic resonance imaging (MRI).MethodsThis is a retrospective study of children with JIA who underwent TMJ IASIs at Boston Children’s Hospital. Patients were included if they had contrast-enhanced MRIs both pre... περισσότερα »
Masthead
Publication date: July 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 7 http://ift.tt/29Ut33k
Editorial Board Page
Publication date: July 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 7 http://ift.tt/2a06QUp
Table of Contents
Publication date: July 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 7 http://ift.tt/29Utfjn
Comment on “Case Reports of Two Unusual Donor Site Complications of the Pectoralis Major Myocutaneous Flap and Literature Review” by Beomjune Kim, Arshad Kaleem, and Waleed Zaid
Publication date: Available online 9 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Ayat Allah Oufkir, Rida Chadli, Mouad Kajout, Mohammed Noureddine El Amine El Alami http://ift.tt/2a06v4i
AAOMS Author Disclosure forms
Publication date: July 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 7 http://ift.tt/29Ut33n
News and Announcements
Publication date: July 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 7 http://ift.tt/2a06kFU
In Reply
Publication date: Available online 9 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Beomjune Kim, Arshad Kaleem, Waleed Zaid from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/29UsW7P via IFTTT
Quantifying the Effect of TMJ Intra-articular Steroid Injection on Synovial Enhancement in Juvenile Idiopathic Arthritis
Publication date: Available online 5 July 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Cory M. Resnick, Pouya M. Vakilian, Leonard B. Kaban, Zachary S. Peacock PurposeTo quantify the effect of intra-articular steroid injections (IASI) on temporomandibular joint (TMJ) synovitis in children with juvenile idiopathic arthritis (JIA) using gadolinium enhanced magnetic resonance imaging (MRI).MethodsThis is a retrospective study of children with JIA who underwent TMJ IASIs at Boston Children's Hospital. Patients were included if they had contrast-enhanced MRIs both p... περισσότερα »
Masthead
Publication date: July 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 7 from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/29Ut33k via IFTTT
Editorial Board Page
Publication date: July 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 7 from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/2a06QUp via IFTTT
Microemulsion Based Hydrogel of Tacrolimus for the Treatment of Atopic Dermatitis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Microemulsion Based Hydrogel of Tacrolimus for the Treatment of Atopic Dermatitis: Objective: The aim of the present investigation was to develop microemulsionbased hydrogel of tacrolimus for topical application for the treatment of atopic dermatitis. <p> Methods: Microemulsion containing tacrolimus was developed by water titration method and was successfully incorporated into freshly prepared 1% carbopol 940 […]</p>
Anti-CD20 Antigen-Targeting Therapies for B-cell Lymphoproliferative Malignancies
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Development of Anti-CD20 Antigen-Targeting Therapies for B-cell Lymphoproliferative Malignancies – The State of the Art: For decades, the available anticancer therapies were mostly based on nonspecific cytotoxic regimens. These cytostatic combinations, while effective in some subpopulations of patients, are often limited by extensive toxicity and/or development of tumor resistance. Although standard chemotherapy still remains a […]
The Effects of Statin Therapy on the Human Airway
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
The Effects of Statin Therapy on the Human Airway: Background: Statins have been long known for their lipid-lowering properties however there has been recent interest in their potential to positively influence clinical outcomes in pulmonary disease processes manifesting primarily as airway disorders. <p> Objectives: We review the potential use of statin therapy in respiratory medicine, […]</p>
The Anti-TNF-alpha Monoclonal Antibody, Infliximab
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Effect of Thermal and Shear Stressors on the Physical Properties, Structural Integrity and Biological Activity of the Anti-TNF-alpha Monoclonal Antibody, Infliximab: The influence of thermal and shear stressors on the stability of the anti-TNF-α monoclonal antibody (mAb), Infliximab<sup>®</sup> (INF) was investigated. INF at concentrations of 1, 4 and 10 mg/ml was subjected to thermal stress […]
Phosphodiesterase 4 (PDE4) Inhibitors to Treat Inflammatory Disorders
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Recent Advances Using Phosphodiesterase 4 (PDE4) Inhibitors to Treat Inflammatory Disorders: Animal and Clinical Studies: Phosphodiesterase 4 (PDE4) inhibitors can be effective drugs for treating inflammation in different tissues/organs caused by conditions such as asthma, chronic obstructive pulmonary disease (COPD), psoriasis, and Alzheimer’s disease. It has been demonstrated that PDE4 inhibitors used for drug therapy […]
Emerging Immunotargets in Metastatic Renal Cell Carcinoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Emerging Immunotargets in Metastatic Renal Cell Carcinoma: Renal cell carcinoma (RCC) is one of the most immunoresponsive human cancers. High-dose IL-2 and Interferon-α were once the principle therapies for metastatic RCC, however they had harsh-tolerance profiles and limited response rates. In the last decade, targeted therapies have supplanted cytokine therapy due to higher response rates […]
Phosphodiesterase 4 (PDE4) Inhibitors to Treat Inflammatory Disorders
Recent Advances Using Phosphodiesterase 4 (PDE4) Inhibitors to Treat Inflammatory Disorders: Animal and Clinical Studies: Phosphodiesterase 4 (PDE4) inhibitors can be effective drugs for treating inflammation in different tissues/organs caused by conditions such as asthma, chronic obstructive pulmonary disease (COPD), psoriasis, and Alzheimer’s disease. It has been demonstrated that PDE4 inhibitors used for drug therapy… Continue reading Phosphodiesterase 4 (PDE4) Inhibitors to Treat Inflammatory Disorders
Emerging Immunotargets in Metastatic Renal Cell Carcinoma
Emerging Immunotargets in Metastatic Renal Cell Carcinoma: Renal cell carcinoma (RCC) is one of the most immunoresponsive human cancers. High-dose IL-2 and Interferon-α were once the principle therapies for metastatic RCC, however they had harsh-tolerance profiles and limited response rates. In the last decade, targeted therapies have supplanted cytokine therapy due to higher response rates… Continue reading Emerging Immunotargets in Metastatic Renal Cell Carcinoma
Circulating (CD3−CD19+CD20−IgD−CD27highCD38high) Plasmablasts: A Promising Cellular Biomarker for Immune Activity for Anti-PLA2R1 Related Membranous Nephropathy?
Membranous nephropathy (MN) is a kidney specific autoimmune disease mainly mediated by anti-phospholipase A2 receptor 1 autoantibody (PLA2R1 Ab). The adequate assessment of chimeric anti-CD20 monoclonal antibody, rituximab (RTX), efficacy is still needed to improve clinical outcome of patient with MN. We evaluated the modification of plasmablasts (CD3−CD19+CD20−IgD−), a useful biomarker of RTX response in… Continue reading Circulating (CD3−CD19+CD20−IgD−CD27highCD38high) Plasmablasts: A Promising Cellular Biomarker for Immune Activity for Anti-PLA2R1 Related Membranous Nephropathy?
Inflammation Thread Runs across Medical Laboratory Specialities
We work on the assumption that four major specialities or sectors of medical laboratory assays, comprising clinical chemistry, haematology, immunology, and microbiology, embraced by genome sequencing techniques, are routinely in use. Medical laboratory markers for inflammation serve as model: they are allotted to most fields of medical lab assays including genomics. Incessant coding of assays… Continue reading Inflammation Thread Runs across Medical Laboratory Specialities
Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease
Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease: Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer’s dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on… Continue reading Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease
Biodegradable Polymeric Nanoparticles as the Delivery Carrier for Drug
Biodegradable Polymeric Nanoparticles as the Delivery Carrier for Drug: Background: Drug research and development has entered into the new epoch of innovation formulation, and the drug delivery system has been in the forefront of pharmaceutical innovation. Nanotechnology is widely used in fiber and textiles, electronics, space, agriculture, forensic science and medical therapeutics. It increasingly plays… Continue reading Biodegradable Polymeric Nanoparticles as the Delivery Carrier for Drug
Nocardia asteroides-Induced movement abnormalities in mice: Relevance for Parkinson’s disease?
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29FGGlb via IFTTT
The emerging roles of Jab1/CSN5 in cancer
Abstract C-Jun activation domain-binding protein-1 (Jab1) not only is full but also a subunit (CSN5) of the constitutive photomorphogenesis 9 signalosome (CSN), which is an evolutionarily conserved and multifunctional protein that involves in controlling cellular proliferation and apoptosis, affecting a series of pathways, as well as regulating genomic instability and DNA damage and repair. The… Continue reading The emerging roles of Jab1/CSN5 in cancer
Descending Projections from the Inferior Colliculus to Medial Olivocochlear Efferents: Mice with Normal Hearing, Early Onset Hearing Loss, and Congenital Deafness
Publication date: Available online 12 July 2016 Source:Hearing Research Author(s): Kirupa Suthakar, David K. Ryugo Auditory efferent neurons reside in the brain and innervate the sensory hair cells of the cochlea to modulate incoming acoustic signals. Two groups of efferents have been described in mouse and this report will focus on the medial olivocochlear (MOC)… Continue reading Descending Projections from the Inferior Colliculus to Medial Olivocochlear Efferents: Mice with Normal Hearing, Early Onset Hearing Loss, and Congenital Deafness
Descending Projections from the Inferior Colliculus to Medial Olivocochlear Efferents: Mice with Normal Hearing, Early Onset Hearing Loss, and Congenital Deafness
Publication date: Available online 12 July 2016 Source:Hearing Research Author(s): Kirupa Suthakar, David K. Ryugo Auditory efferent neurons reside in the brain and innervate the sensory hair cells of the cochlea to modulate incoming acoustic signals. Two groups of efferents have been described in mouse and this report will focus on the medial olivocochlear (MOC)… Continue reading Descending Projections from the Inferior Colliculus to Medial Olivocochlear Efferents: Mice with Normal Hearing, Early Onset Hearing Loss, and Congenital Deafness
Butterfly myringoplasty for total, subtotal, and annular perforations
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis The inlay "butterfly" cartilage tympanoplasty was first described as a treatment for small, central ear drum perforations. This technique can also be applied in large, marginal perforations, whereas the cartilage graft is anchored on the bony annulus. The aim of this study was to present the technique, to evaluate the results of butterfly tympanoplasty in marginal perforations, and to compare with the results of butterfly tympanoplasty in patients with nonmarginal perforations. Study Design Retrospective cas... περισσότερα »
Forgetful but not forgotten: Bathroom-related craniofacial trauma among the elderly
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis As our population ages, injuries attributable to falls continue to increase, impacting healthcare delivery. Evaluation of craniofacial trauma with focus on elderly patients remains an underappreciated concern. Our objectives were to evaluate injury trends associated with elderly bathroom falls, as this information may be useful for counseling and preventive purposes. Study Design Database review. Methods The National Electronic Injury Surveillance System was evaluated for craniofacial trauma among patients... περισσότερα »
Low surgical complication rates in cochlear implantation for young children less than 1 year of age
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objective To identify risk factors for perioperative morbidity among a large national cohort of pediatric patients undergoing cochlear implantation. Study Design Retrospective study utilizing the American College of Surgeons National Surgical Quality Improvement Program Pediatric database (2012–2013). Methods Pediatric cochlear implantation cases were identified using current procedural terminology 69930. Patients were categorized by age, and operative characteristics along with 30-day perioperative outcomes were analyzed. Resul... περισσότερα »
Multimodality assessment of upper airway obstruction in children with persistent obstructive sleep apnea after adenotonsillectomy
Objectives/Hypothesis Children with obstructive sleep apnea (OSA) may have multiple sites of upper airway obstruction (UAO). A wide variety of techniques has been used to evaluate UAO. Our aim was to compare findings of cine magnetic resonance imaging (MRI) and drug-induced sleep endoscopy (DISE) in identifying UAO sites in children with persistent OSA after adenotonsillectomy (AT). Study Design Retrospective chart review. Material and Methods The medical records of children who underwent DISE and cine MRI were reviewed. Data pertaining to demographics, past medical history, bod... περισσότερα »
Prevention of vocal fold scarring by local application of basic fibroblast growth factor in a rat vocal fold injury model
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Vocal fold scarring, which causes severe hoarseness, is intractable. The optimal treatment for vocal fold scarring has not been established; therefore, prevention of scarring is important. The aim of this study was to clarify the effectiveness of basic fibroblast growth factor (bFGF) for prevention of postsurgical vocal fold scarring. Study Design Prospective animal experiments with controls. Method The vocal folds of Sprague-Dawley rats were injured unilaterally or bilaterally after local application of a ... περισσότερα »
Safety and postoperative adverse events in pediatric airway reconstruction: Analysis of ACS-NSQIP-P 30-day outcomes
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives Prior research has shown that airway reconstructive procedures comprise significant composite morbidity compared to the whole of pediatric otolaryngologic cases evaluated in the American College of Surgeon's National Surgery Quality Improvement Program-Pediatric (ACS-NSQIP-P) platform. We describe postoperative sequelae of pediatric airway reconstructive procedures and identify predictive factors for adverse events. Methods Current procedural terminology (CPT) codes were used to identify children undergoing included p... περισσότερα »
Investigation into the presence of human papillomavirus in patients with obstructive sleep apnea
[image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis The human papillomavirus (HPV) is known to infect the tissues of the oropharynx as demonstrated in HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). HPV has also been shown to induce benign lymphoid hypertrophy. We sought to investigate an association between obstructive sleep apnea (OSA) and the presence of HPV in palatine and lingual tonsillar oropharyngeal tissue. Study Design Case series with chart review. Methods This retrospective laboratory-based study of oropharyngeal tissue from patients... περισσότερα »
Descending Projections from the Inferior Colliculus to Medial Olivocochlear Efferents: Mice with Normal Hearing, Early Onset Hearing Loss, and Congenital Deafness
[image: S03785955.gif] Publication date: Available online 12 July 2016 *Source:*Hearing Research Author(s): Kirupa Suthakar, David K. Ryugo Auditory efferent neurons reside in the brain and innervate the sensory hair cells of the cochlea to modulate incoming acoustic signals. Two groups of efferents have been described in mouse and this report will focus on the medial olivocochlear (MOC) system. Electrophysiological data suggest the MOC efferents function in selective listening by differentially attenuating auditory nerve fiber activity in quiet and noisy conditions. Because speech ... περισσότερα »
Granulomatosis with Polyangiitis with Bilateral Facial Palsy and Severe Mixed Hearing Loss
Granulomatosis with polyangiitis is autoimmune and rare disease. It affects many organs, but the most often affected organs are the nose, lungs, and kidneys. It is part of vasculitis and causes an autoimmune attack by an abnormal type of circulating antibody termed ANCAs against small blood vessels. Disease concerns both men and women with a peak age of presentation in the sixth and seven decades. Typically upper and lower respiratory tract and kidneys are involved. Otitis externa, otitis media, or mastoiditis rarely occurs in granulomatosis with polyangiitis. Deafness is the most... περισσότερα »
High-dose hypofractionated radiotherapy is effective and safe for tumors in the head-and-neck
Publication date: September 2016 *Source:*Oral Oncology, Volume 60 Author(s): Sewit Teckie, Benjamin H. Lok, Shyam Rao, Stanley I. Gutiontov, Yoshiya Yamada, Sean L. Berry, Michael J. Zelefsky, Nancy Y. Lee ObjectivesHigh-dose, hypofractionated radiotherapy (HFRT) is sometimes used to treat malignancy in the head-and-neck (HN), both in the curative and palliative setting. Its safety and efficacy have been reported in small studies and are still controversial.Materials and methodsWe retrospectively evaluated the outcomes and toxicities of HFRT, including ultra-high-dose fractionation... περισσότερα »
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
New England Journal of Medicine, Ahead of Print. http://ift.tt/29QfoMe
Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease: Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer’s dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on […]
Biodegradable Polymeric Nanoparticles as the Delivery Carrier for Drug
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Biodegradable Polymeric Nanoparticles as the Delivery Carrier for Drug: Background: Drug research and development has entered into the new epoch of innovation formulation, and the drug delivery system has been in the forefront of pharmaceutical innovation. Nanotechnology is widely used in fiber and textiles, electronics, space, agriculture, forensic science and medical therapeutics. It increasingly plays […]
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otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Publication date: Available online 12 July 2016Source:Journal of Allergy and Clinical Immunology Author(s): Markus J. Ege, Michael W. Pfaffl http://ift.tt/29S0YwQ http://ift.tt/29S2Rtt
Rapid Molecular Diagnostics of Severe Primary Immunodeficiency by Targeted Next Generation Sequencing
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Publication date: Available online 12 July 2016Source:Journal of Allergy and Clinical Immunology Author(s): Hui Yu, Victor Wei Zhang, Asbjørg Stray-Pedersen, Imelda Celine Hanson, Lisa R. Forbes, M. Teresa de la Morena, Ivan K. Chinn, Elizabeth Gorman, Nancy J. Mendelsohn, Tamara Pozos, Wojciech Wiszniewski, Sarah K. Nicholas, Anne B. Yates, Lindsey E. Moore, Knut Erik Berge, […]
Rapid Molecular Diagnostics of Severe Primary Immunodeficiency by Targeted Next Generation Sequencing
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Publication date: Available online 12 July 2016Source:Journal of Allergy and Clinical Immunology Author(s): Hui Yu, Victor Wei Zhang, Asbjørg Stray-Pedersen, Imelda Celine Hanson, Lisa R. Forbes, M. Teresa de la Morena, Ivan K. Chinn, Elizabeth Gorman, Nancy J. Mendelsohn, Tamara Pozos, Wojciech Wiszniewski, Sarah K. Nicholas, Anne B. Yates, Lindsey E. Moore, Knut Erik Berge, […]
The safety of intranasal steroids during pregnancy: A good start
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Publication date: July 2016Source:Journal of Allergy and Clinical Immunology, Volume 138, Issue 1 Author(s): Jennifer A. Namazy, Michael Schatz http://ift.tt/29RPLti http://ift.tt/29S2grH
Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Publication date: July 2016Source:Journal of Allergy and Clinical Immunology, Volume 138, Issue 1 Author(s): Timothy S.C. Hinks, Tom Brown, Laurie C.K. Lau, Hitasha Rupani, Clair Barber, Scott Elliott, Jon A. Ward, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Ratko Djukanović, Ramesh J. Kurukulaaratchy, Anoop Chauhan, Peter H. HowarthBackgroundDisease heterogeneity in patients with severe asthma and its […]
Successful hematopoietic stem cell transplantation for myelofibrosis in an adult with Warts-Hypogammaglobulinemia-Immunodeficiency-Myelokathexis syndrome
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Publication date: Available online 12 July 2016Source:Journal of Allergy and Clinical Immunology Author(s): Leen Moens, Glynis Frans, Barbara Bosch, Xavier Bossuyt, Bert Verbinnen, Willy Poppe, Nancy Boeckx, Mary Slatter, Caroline Brusselmans, George Diaz, Thomas Tousseyn, Helena Flipts, Anniek Corveleyn, Daan Dierickx, Isabelle Meyts Teaser Capsule Summary: Myelofibrosis can develop in patients with WHIM syndrome – […]
Milk: An epigenetic inducer of FoxP3 expression
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Publication date: Available online 12 July 2016Source:Journal of Allergy and Clinical Immunology Author(s): Bodo C. Melnik, Swen Malte John, Gerd Schmitz http://ift.tt/29S0UwZ http://ift.tt/29F5MpS
Cover 1
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Publication date: July 2016Source:Journal of Allergy and Clinical Immunology, Volume 138, Issue 1 http://ift.tt/29S12Nm http://ift.tt/2abWE7X
Management of Inflammation by Natural Polyphenols: A Comprehensive Mechanistic Update
Management of Inflammation by Natural Polyphenols: A Comprehensive Mechanistic Update: Inflammation generates a systemic response against injury or infection from bacteria, viruses, and other pathogens. The welfare of host is the primary target of this process. However, uncontrolled or inadequate regulation of the inflammatory response produces detrimental effects leading to the generation of various chronic disorders including atherosclerosis, type-2 diabetes, neurodegenerative disease, cancer and Alzheimer’s disease with severe tissue damage. The exact identity of the inflammatory... περισσότερα »
Oxidative Stress Modulation Through Habitual Physical Activity
Oxidative Stress Modulation Through Habitual Physical Activity: Background: Oxidative stress is involved in different pathophysiological states, such as aging, inflammatory, cardiovascular and neurodegenerative diseases, by damaging several cellular and tissue components including proteins, DNA and lipids. On the other hand, free radicals generated during physical activity are important modulators of muscle contraction, antioxidant protection, and oxidative damage repair. Indeed, ROS, generated during physical activity, are likely main mediators of antioxidant molecules upregulation,... περισσότερα »
Microemulsion Based Hydrogel of Tacrolimus for the Treatment of Atopic Dermatitis
Microemulsion Based Hydrogel of Tacrolimus for the Treatment of Atopic Dermatitis: Objective: The aim of the present investigation was to develop microemulsionbased hydrogel of tacrolimus for topical application for the treatment of atopic dermatitis. <p> Methods: Microemulsion containing tacrolimus was developed by water titration method and was successfully incorporated into freshly prepared 1% carbopol 940 gels. Preformulation studies such as preparation of standard curve by HPLC, solubility studies and construction of phase diagrams were carried out. Lauroglycol was selected...</p>
Anti-CD20 Antigen-Targeting Therapies for B-cell Lymphoproliferative Malignancies
Development of Anti-CD20 Antigen-Targeting Therapies for B-cell Lymphoproliferative Malignancies - The State of the Art: For decades, the available anticancer therapies were mostly based on nonspecific cytotoxic regimens. These cytostatic combinations, while effective in some subpopulations of patients, are often limited by extensive toxicity and/or development of tumor resistance. Although standard chemotherapy still remains a common therapeutic tool in the fight with cancer, immunotherapy increasingly revolutionizes treatment strategy for several hematologic malignancies. For a su... περισσότερα »
The Effects of Statin Therapy on the Human Airway
The Effects of Statin Therapy on the Human Airway: Background: Statins have been long known for their lipid-lowering properties however there has been recent interest in their potential to positively influence clinical outcomes in pulmonary disease processes manifesting primarily as airway disorders. <p> Objectives: We review the potential use of statin therapy in respiratory medicine, with particular emphasis on airway disease. We also explore the possible mechanisms for the observed benefits of statins in conditions of the airway. </p><p> Method: A literary review of published...</p>
The Anti-TNF-alpha Monoclonal Antibody, Infliximab
Effect of Thermal and Shear Stressors on the Physical Properties, Structural Integrity and Biological Activity of the Anti-TNF-alpha Monoclonal Antibody, Infliximab: The influence of thermal and shear stressors on the stability of the anti-TNF-α monoclonal antibody (mAb), Infliximab<sup>®</sup> (INF) was investigated. INF at concentrations of 1, 4 and 10 mg/ml was subjected to thermal stress at temperatures of 25-65°C and to shear force by sonication for 1 and 3 minutes. The stressed samples were analysed for physical properties by particle size, zeta potential, for structural integ... περισσότερα »
Phosphodiesterase 4 (PDE4) Inhibitors to Treat Inflammatory Disorders
Recent Advances Using Phosphodiesterase 4 (PDE4) Inhibitors to Treat Inflammatory Disorders: Animal and Clinical Studies: Phosphodiesterase 4 (PDE4) inhibitors can be effective drugs for treating inflammation in different tissues/organs caused by conditions such as asthma, chronic obstructive pulmonary disease (COPD), psoriasis, and Alzheimer’s disease. It has been demonstrated that PDE4 inhibitors used for drug therapy provide some advantages over conventional formulations, including sensitivity to selective inhibitors, unique tissue distribution, and ease of oral administration. T... περισσότερα »
Emerging Immunotargets in Metastatic Renal Cell Carcinoma
Emerging Immunotargets in Metastatic Renal Cell Carcinoma: Renal cell carcinoma (RCC) is one of the most immunoresponsive human cancers. High-dose IL-2 and Interferon-α were once the principle therapies for metastatic RCC, however they had harsh-tolerance profiles and limited response rates. In the last decade, targeted therapies have supplanted cytokine therapy due to higher response rates and more favorable toxicity profiles. Emerging immunotherapies targeting the PD-1 receptor and PD-L1 ligand have shown promising results. Likewise, other novel targeted immunotherapies are curren... περισσότερα »
Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease
Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease: Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer’s dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on progranulin regulation in neurodegenerative diseases remains limited. We here demonstrate that cerebrospinal fluid progranulin levels do not correlate with its serum level... περισσότερα »
Biodegradable Polymeric Nanoparticles as the Delivery Carrier for Drug
Biodegradable Polymeric Nanoparticles as the Delivery Carrier for Drug: Background: Drug research and development has entered into the new epoch of innovation formulation, and the drug delivery system has been in the forefront of pharmaceutical innovation. Nanotechnology is widely used in fiber and textiles, electronics, space, agriculture, forensic science and medical therapeutics. It increasingly plays a significant role in drug delivery system. Compared with traditional delivery system, the nanoparticle drug delivery system has lots of merits, such as the high drug loading abilit... περισσότερα »
An unusual recruitment strategy in a mass-recruiting stingless bee, Partamona orizabaensis
Abstract Foragers of several stingless bee species deposit attractive scent marks on solid substrates to precisely recruit nestmates to food. Interestingly, *Partamona* workers quickly recruit large numbers of nest mates to resources, likely even without the deposition of attractive scent marks. However, systematic studies of the recruitment system of these bees are lacking. We now studied the recruitment behavior of *P. orizabaensis*. Our findings show that foragers of this species can recruit large numbers of nestmates to food sources at a particular location. The precise nestmate... περισσότερα »
Temporal prediction modulates the evaluative processing of “good” action feedback: An electrophysiological study
Abstract The present study aimed to investigate whether or not the evaluative processing of action feedback can be modulated by temporal prediction. For this purpose, we examined the effects of the predictability of the timing of action feedback on an ERP effect that indexed the evaluative processing of action feedback, that is, an ERP effect that has been interpreted as a feedback-related negativity (FRN) elicited by “bad” action feedback or a reward positivity (RewP) elicited by “good” action feedback. In two types of experimental blocks, the participants performed a gambling task... περισσότερα »
Reduced amygdala responsivity during conditioning to trauma-related stimuli in posttraumatic stress disorder
Abstract Exaggerated conditioned fear responses and impaired extinction along with amygdala overactivation have been observed in posttraumatic stress disorder (PTSD). These fear responses might be triggered by cues related to the trauma through higher-order conditioning, where reminders of the trauma may serve as unconditioned stimuli (US) and could maintain the fear response. We compared arousal, valence, and US expectancy ratings and BOLD brain responses using fMRI in 14 traumatized persons with PTSD and 14 without PTSD (NPTSD) and 13 matched healthy controls (HC) in a differentia... περισσότερα »
Patients with chronic insomnia have selective impairments in memory that are modulated by cortisol
Abstract Memory impairment is a frequent complaint in insomniacs; however, it is not consistently demonstrated. It is unknown whether memory impairment in insomniacs involves neuroendocrine dysfunction. The participants in this study were selected from the clinical setting and included 21 patients with chronic insomnia disorder (CID), 25 patients with insomnia and comorbid depressive disorder (CDD), and 20 control participants without insomnia. We evaluated spatial working and reference memory, object working and reference memory, and object recognition memory using the Nine Box Maz... περισσότερα »
Circulating (CD3−CD19+CD20−IgD−CD27highCD38high) Plasmablasts: A Promising Cellular Biomarker for Immune Activity for Anti-PLA2R1 Related Membranous Nephropathy?
Membranous nephropathy (MN) is a kidney specific autoimmune disease mainly mediated by anti-phospholipase A2 receptor 1 autoantibody (PLA2R1 Ab). The adequate assessment of chimeric anti-CD20 monoclonal antibody, rituximab (RTX), efficacy is still needed to improve clinical outcome of patient with MN. We evaluated the modification of plasmablasts (CD3−CD19+CD20−IgD−), a useful biomarker of RTX response in other autoimmune diseases, and memory (CD3−CD19+CD20+IgD−CD27+CD38−) and naive (CD3−CD19+CD20+IgD+CD27−) B cells by fluorescence-activated cell sorter analysis in PLA2R1 related M... περισσότερα »
Inflammation Thread Runs across Medical Laboratory Specialities
We work on the assumption that four major specialities or sectors of medical laboratory assays, comprising clinical chemistry, haematology, immunology, and microbiology, embraced by genome sequencing techniques, are routinely in use. Medical laboratory markers for inflammation serve as model: they are allotted to most fields of medical lab assays including genomics. Incessant coding of assays aligns each of them in the long lists of big data. As exemplified with the complement gene family, containing C2, C3, C8A, C8B, CFH, CFI, and ITGB2, heritability patterns/risk factors associa... περισσότερα »
Progression of cognitive impairments in idiopathic REM sleep behaviour disorder
Background Idiopathic REM (rapid eye movement) sleep behaviour disorder (iRBD) has been implicated in cognitive impairments, but there is little evidence about progression of cognitive dysfunction in iRBD. Methods A retrospective follow-up study with patients with iRBD was performed. Conversion to neurodegenerative disorders was analysed by Kaplan-Meier survival analysis. Neuropsychological test results at baseline were compared between patients with iRBD and healthy controls. 57 patients with iRBD were successfully followed up for changes of cognitive performance over time (fo... περισσότερα »
Incident impulse control disorder symptoms and dopamine transporter imaging in Parkinson disease
Objective To describe the incidence of, and clinical and neurobiological risk factors for, new-onset impulse control disorder (ICD) symptoms and related behaviours in early Parkinson disease (PD). Methods The Parkinson's Progression Markers Initiative is an international, multicenter, prospective study of de novo patients with PD untreated at baseline and assessed annually, including serial dopamine transporter imaging (DAT-SPECT) and ICD assessment (Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease short form, QUIP). Participants were included if they scr... περισσότερα »
Clinical features of the myasthenic syndrome arising from mutations in GMPPB
Background Congenital myasthenic syndrome (CMS) due to mutations in *GMPPB* has recently been reported confirming the importance of glycosylation for the integrity of neuromuscular transmission. Methods Review of case notes of patients with mutations in *GMPPB* to identify the associated clinical, neurophysiological, pathological and laboratory features. In addition, serum creatine kinase (CK) levels within the Oxford CMS cohort were retrospectively analysed to assess its usefulness in the differential diagnosis of this new entity. Results All patients had prominent limb-girdl... περισσότερα »
The habenula: an under-recognised area of importance in frontotemporal dementia?
Introduction Behavioural variant frontotemporal dementia (bvFTD) is a neurodegenerative disorder characterised by atrophy of the frontal and temporal lobes and progressive behavioural and cognitive impairment. Some behavioural symptoms such as craving for food, alcohol or drugs, and hypersexuality are suggestive of abnormal reward processing. The reward circuit is formed by a number of different structures including the orbitofrontal cortex, ventral striatum (in particular the nucleus accumbens), ventral pallidum, anterior cingulate cortex, thalamus, hypothalamus, midbrain and ha... περισσότερα »
Non-neural phenotype of spinal and bulbar muscular atrophy: results from a large cohort of Italian patients
Objective To carry out a deep characterisation of the main androgen-responsive tissues involved in spinal and bulbar muscular atrophy (SBMA). Methods 73 consecutive Italian patients underwent a full clinical protocol including biochemical and hormonal analyses, genitourinary examination, bone metabolism and densitometry, cardiological evaluation and muscle pathology. Results Creatine kinase levels were slightly to markedly elevated in almost all cases (68 of the 73; 94%). 30 (41%) patients had fasting glucose above the reference limit, and many patients had total cholesterol (... περισσότερα »
MRI characteristics of early PML-IRIS after natalizumab treatment in patients with MS
Objective The early detection of MRI findings suggestive of immune reconstitution inflammatory syndrome (IRIS) in natalizumab-associated progressive multifocal leukoencephalopathy (PML) is of crucial clinical relevance in terms of treatment decision-making and clinical outcome. The aim of this study was to investigate the earliest imaging characteristics of PML-IRIS manifestation in natalizumab-treated patients with multiple sclerosis and describe an imaging pattern that might aid in the early and specific diagnosis. Methods This was a retrospective study assessing brain MRI of... περισσότερα »
Traumatic brain injury history is associated with earlier age of onset of frontotemporal dementia
Objective We retrospectively examined whether a history of traumatic brain injury (TBI) is associated with an earlier age of symptom onset and diagnosis in a large sample of patients with behavioural variant frontotemporal dementia (bvFTD). Methods Data on patients with bvFTD (n=678) were obtained from the National Alzheimer's Coordinating Center Uniform Data Set. TBI was categorised based on reported lifetime history of TBI with loss of consciousness (LOC) but no chronic deficits occurring more than 1 year prior to diagnosis of bvFTD. Analysis of covariance (ANCOVA) was used t... περισσότερα »
The distinctive genetic architecture of ALS in mainland China
Introduction Since 1993, more than 20 genes have been found to be implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS).1 Recent studies have shown that *C9orf72*, *SOD1*, *TARDBP* and *FUS* are the most common mutated genes in ALS in Caucasian populations; these genes are considered major ALS-related genes.2–6 However, the genetic patterns of ALS in mainland China remain obscure. Therefore, we screened mutations in the major ALS genes in a large cohort of patients with ALS from mainland China. We also compared our results with those reported by previous populati... περισσότερα »
Amyotrophic lateral sclerosis and motor neuron syndromes in Asia
While the past 2 decades have witnessed an increasing understanding of amyotrophic lateral sclerosis (ALS) arising from East Asia, particularly Japan, South Korea, Taiwan and China, knowledge of ALS throughout the whole of Asia remains limited. Asia represents >50% of the world population, making it host to the largest patient cohort of ALS. Furthermore, Asia represents a diverse population in terms of ethnic, social and cultural backgrounds. In this review, an overview is presented that covers what is currently known of ALS in Asia from basic epidemiology and genetic influences, ... περισσότερα »
Is the serum creatine kinase level elevated in congenital myasthenic syndrome?
Congenital myasthenic syndrome (CMS) caused by mutations in *GMPPB* shows features of dystroglycanopathy with elevated serum creatine kinase (CK) and mild cognitive delay. In their *JNNP* paper, Rodriguez Cruz *et al*1 report clinical features of eight patients with CMS carrying mutations in *GMPPB. GMPPB* encodes a glycosynthetic enzyme, GDP-mannose pyrophosphorylase B, that catalyses the conversion of mannose-1-phosphate and GTP to GDP-mannose. GDP-mannose is an essential substrate for both N-glycosylation and O-mannosylation.2 Mutations in genes in the O-mannosylation pathway w... περισσότερα »
FRONTIER Executive Screen: a brief executive battery to differentiate frontotemporal dementia and Alzheimer's disease
Background and objective Executive dysfunctions are a key clinical feature of behavioural-variant frontotemporal dementia (bvFTD). Such deficits are also found in Alzheimer's disease (AD), making the differentiation between these two diseases difficult at times, particularly in the absence of extensive cognitive assessments. To address this issue, we developed the FRONTIER Executive Screen (FES), which combines three abbreviated measures of verbal fluency, inhibitory control and working memory. Methods We administered the FES to 28 patients with dementia (14 bvFTD, 14 AD) match... περισσότερα »
The prediagnostic phase of Parkinson's disease
The field of prediagnostic Parkinson's disease (PD) is fast moving with an expanding range of clinical and laboratory biomarkers, and multiple strategies seeking to discover those in the earliest stages or those 'at risk'. It is widely believed that the highest likelihood of securing neuroprotective benefit from drugs will be in these subjects, preceding current point of diagnosis of PD. In this review, we outline current knowledge of the prediagnostic phase of PD, including an up-to-date review of risk factors (genetic and environmental), their relative influence, and clinical fe... περισσότερα »
Meyer's loop asymmetry and language lateralisation in epilepsy
Objectives Several studies have suggested an asymmetry in Meyer's loop in individuals, with the left loop anterior to the right. In this study we test the hypothesis that there is an association between Meyer's loop asymmetry (MLA) and language lateralisation. Methods 57 patients with epilepsy were identified with language functional MRI (fMRI) and diffusion MRI acquisition. Language lateralisation indices from fMRI(LI) and optic radiation and arcuate fasciculus probabilistic tractography was performed for each subject. The subjects were divided into left language dominant (LI>... περισσότερα »
Extended interval dosing of natalizumab in multiple sclerosis
Background Natalizumab (NTZ), a monoclonal antibody to human α4β1/β7 integrin, is an effective therapy for multiple sclerosis (MS), albeit associated with progressive multifocal leukoencephalopathy (PML). Clinicians have been extending the dose of infusions with a hypothesis of reducing PML risk. The aim of the study is to evaluate the clinical consequences of reducing NTZ frequency of infusion up to 8 weeks 5 days. Methods A retrospective chart review in 9 MS centres was performed in order to identify patients treated with extended interval dosing (EID) regimens of NTZ. Patien... περισσότερα »
Outcome of seizures in the general population after 25 years: a prospective follow-up, observational cohort study
Objectives We investigated long-term (to 25 years) seizure prognosis and survival in people with newly diagnosed epilepsy in the community. We explored whether prognosis is different in those with epilepsy (>2 unprovoked seizures) and those with a single seizure at presentation. Methods This is a prospective observational cohort study of people with newly diagnosed seizures. We investigated seizure outcome and survival in people presenting with a single seizure and in those presenting with >2 seizures (epilepsy). Results 695 people (median follow-up 23.6 years) had unprovoked ... περισσότερα »
Antibodies to MOG and AQP4 in children with neuromyelitis optica and limited forms of the disease
Objective To determine the frequency and clinical-radiological associations of antibodies to myelin oligodendrocyte glycoprotein (MOG) and aquaporin-4 (AQP4) in children presenting with neuromyelitis optica (NMO) and limited forms. Methods Children with a first event of NMO, recurrent (RON), bilateral ON (BON), longitudinally extensive transverse myelitis (LETM) or brainstem syndrome (BS) with a clinical follow-up of more than 12 months were enrolled. Serum samples were tested for MOG- and AQP4-antibodies using live cell-based assays. Results 45 children with NMO (n=12), LETM... περισσότερα »
A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN
Objective To classify the patterns of functional decline in patients with sporadic amyotrophic lateral sclerosis (ALS) and explore the genetic backgrounds that modified these patterns. Methods We included 465 patients with sporadic ALS in the analysis and clustered the longitudinal functional scores in the registered patients, using a mixture approach of a non-linear mixed-effects model. We conducted a genome-wide analysis of 572 983 single nucleotide polymorphisms (SNPs). We then assessed the association between the clusters of longitudinal functional scores and SNPs. Results ... περισσότερα »
Severe parkinsonism associated with anti-CRMP5 antibody-positive paraneoplastic neurological syndrome and abnormal signal intensity in the bilateral basal ganglia
Introduction Anticollapsin response mediator protein 5 antibody (anti-CRMP5 antibody, also known as anti-CV2 antibody) is usually associated with small-cell lung carcinoma (SCLC) or thymoma.1 Although optic neuropathy, cerebellar ataxia and chorea are considered typical clinical features of paraneoplastic neurological syndrome (PNS) associated with anti-CRMP5 antibody, the neurological involvement of anti-CRMP5 antibody is broader.1 We report the first known case with anti-CRMP5 antibody-associated PNS presenting with predominant parkinsonism and bilateral signal abnormalities in... περισσότερα »
Sequence of electrode implantation and outcome of deep brain stimulation for Parkinson's disease
Introduction The effect of the variability of electrode placement on outcomes after bilateral deep brain stimulation of subthalamic nucleus has not been sufficiently studied, especially with respect to the sequence of hemisphere implantation. Methodology We retrospectively analysed the clinical and radiographic data of all the consecutive patients with Parkinson's disease who underwent surgery at our centre and completed at least 1 year follow-up. The dispersion in electrode location was calculated by the square of deviation from population mean, and the direction of deviation ... περισσότερα »
Recovery from an acute relapse is associated with changes in motor resting-state connectivity in multiple sclerosis
Introduction Resting-state functional MRI (rs-fMRI) of the brain has been successfully used to identify altered functional connectivity in the motor network in multiple sclerosis (MS).1 In clinically stable patients with MS, we recently demonstrated increased coupling between the basal ganglia and the motor network.1 Accordingly, rs-fMRI in MS is particularly suited to investigate functional reorganisation of the motor network in the remission phase after a relapse because the resting-state connectivity pattern is not influenced by interindividual differences in motor ability and... περισσότερα »
Covered stents for exclusion of iatrogenic common carotid artery-internal jugular vein fistula and brachiocephalic artery pseudoaneurysm
Covered stents have rarely been used in neuroendovascular procedures. We report the case of a 74-year-old woman with a complex iatrogenic vascular injury from attempted insertion of a hemodialysis catheter: concurrent brachiocephalic artery pseudoaneurysm and common carotid artery to internal jugular vein fistula. Both lesions were excluded successfully by using two balloon-expandable covered stents with a satisfactory short-term clinical and angiographic outcome. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/29xh120 via IFTTT
Acute ischemic stroke in a child due to basilar artery occlusion treated successfully with a stent retriever
Ischemic strokes in childhood are rare. Thrombolytic therapy with intravenous (IV) tissue plasminogen activator (tPA) has been the main intervention for the management of pediatric stroke patients, but safety data are lacking and efficacy has been questioned. Recently, successful endovascular treatments for acute ischemic stroke in children have been reported with increasing frequency, suggesting that mechanical thrombectomy can be a safe and effective treatment. We present the case of a 22-month-old child with acute ischemic stroke due to basilar artery occlusion that was success... περισσότερα »
Transvenous sclerotherapy of a large symptomatic orbital venous varix using a microcatheter balloon and bleomycin
An orbital venous varix is rare and can present with diplopia, proptosis, or hemorrhage. Treatment can be challenging, especially if the varix is in a posterior location within the orbit, since surgical exposure becomes difficult. A few case reports have been published describing transcatheter embolization of an orbital varix with coils, direct percutaneous injection of n-butyl cyanoacrylate glue, and the percutaneous injection of bleomycin. We present a case of a symptomatic orbital venous varix of the left inferior ophthalmic vein successfully treated with transvenous endovascula... περισσότερα »
Initial experience of coiling cerebral aneurysms using the new Comaneci device
We present our initial patient experience with an innovative temporary bridging device, the Comaneci (Rapid Medical, Israel), to assist in the coiling of cerebral aneurysms. The Comaneci device confers the same benefits as balloon remodeling but without the risks of parent artery occlusion. This alleviates time pressure on the clinician, and could reduce the risk of parent artery thrombosis. Three patients were treated with the Comaneci device. Two patients had acute ruptured posterior communicating aneurysms and one patient was treated electively for a carotico-ophthalmic aneurys... περισσότερα »
MACRA: background, opportunities and challenges for the neurointerventional specialist
The legislative branch of government took many by surprise when it announced the Medicare Access and CHIP Reauthorization Act of 2015. Once the Act was passed, President Obama quickly signed this bipartisan, bicameral effort into law. A foundational element of this legislation was the permanent repeal of the sustainable growth rate formula. Physicians and their patients were appropriately enthusiastic about this development. The Medicare Access and CHIP Reauthorization Act of 2015 included additional elements of considerable interest to neurointerventional specialists. from Neuro... περισσότερα »
Descending Projections from the Inferior Colliculus to Medial Olivocochlear Efferents: Mice with Normal Hearing, Early Onset Hearing Loss, and Congenital Deafness
[image: S03785955.gif] Publication date: Available online 12 July 2016 *Source:*Hearing Research Author(s): Kirupa Suthakar, David K. Ryugo Auditory efferent neurons reside in the brain and innervate the sensory hair cells of the cochlea to modulate incoming acoustic signals. Two groups of efferents have been described in mouse and this report will focus on the medial olivocochlear (MOC) system. Electrophysiological data suggest the MOC efferents function in selective listening by differentially attenuating auditory nerve fiber activity in quiet and noisy conditions. Because speech ... περισσότερα »
Descending Projections from the Inferior Colliculus to Medial Olivocochlear Efferents: Mice with Normal Hearing, Early Onset Hearing Loss, and Congenital Deafness
[image: S03785955.gif] Publication date: Available online 12 July 2016 *Source:*Hearing Research Author(s): Kirupa Suthakar, David K. Ryugo Auditory efferent neurons reside in the brain and innervate the sensory hair cells of the cochlea to modulate incoming acoustic signals. Two groups of efferents have been described in mouse and this report will focus on the medial olivocochlear (MOC) system. Electrophysiological data suggest the MOC efferents function in selective listening by differentially attenuating auditory nerve fiber activity in quiet and noisy conditions. Because speech ... περισσότερα »
Descending Projections from the Inferior Colliculus to Medial Olivocochlear Efferents: Mice with Normal Hearing, Early Onset Hearing Loss, and Congenital Deafness
[image: S03785955.gif] Publication date: Available online 12 July 2016 *Source:*Hearing Research Author(s): Kirupa Suthakar, David K. Ryugo Auditory efferent neurons reside in the brain and innervate the sensory hair cells of the cochlea to modulate incoming acoustic signals. Two groups of efferents have been described in mouse and this report will focus on the medial olivocochlear (MOC) system. Electrophysiological data suggest the MOC efferents function in selective listening by differentially attenuating auditory nerve fiber activity in quiet and noisy conditions. Because speech ... περισσότερα »
One day left to submit your application to the @uicc YY Fellowships https://t.co/ZYCVGBhfXb https://t.co/1qA41Z94wz
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One day left to submit your application to the @uicc YY Fellowships https://t.co/ZYCVGBhfXb https://t.co/1qA41Z94wz from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/753509414250971136 via IFTTT
PET/MRI: A one-stop imaging test to detect prostate cancer?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A University of Michigan study published in The Journal of Nuclear Medicine reports that the addition of molecular imaging based on F-18-choline positron emission tomography (PET) improves the identification of significant prostate cancer over… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29JukfL via IFTTT
Masthead
Publication date: July 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 7 from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/29Ut33k via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29yMopx via IFTTT
Human population and socioeconomic modulators of conservation performance in 788 Amazonian and Atlantic Forest reserves
[image: fig-1-1x.jpg] Protected areas form a quintessential component of the global strategy to perpetuate tropical biodiversity within relatively undisturbed wildlands, but they are becoming increasingly isolated by rapid agricultural encroachment. Here we consider a network of 788 forest protected areas (PAs) in the world's largest tropical country to examine the degree to which they remain intact, and their responses to multiple biophysical and socioeconomic variables potentially affecting natural habitat loss under varying contexts of rural development. PAs within the complex B... περισσότερα »
The emerging roles of Jab1/CSN5 in cancer
Abstract C-Jun activation domain-binding protein-1 (Jab1) not only is full but also a subunit (CSN5) of the constitutive photomorphogenesis 9 signalosome (CSN), which is an evolutionarily conserved and multifunctional protein that involves in controlling cellular proliferation and apoptosis, affecting a series of pathways, as well as regulating genomic instability and DNA damage and repair. The CSN is a highly conservative protein from yeast to human and interacts with the cullin-RING family of ubiquitin ligases so that it could be execute a process of removing NEDD8, a ubiquitin-... περισσότερα »
Retraction Note to: FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors
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Recent advances in site specific conjugations of antibody drug conjugates
Antibody-drug conjugates take the advantage of antigen specificity of monoclonal antibodies to deliver highly potent cytotoxic drugs selectively to antigen-expressing tumour cells. The recent approval of Adcetris and Kadcyla as well as emerging data… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29FMsDw via IFTTT
Retraction Note to: Platelet-derived growth factor-D contributes to aggressiveness of breast cancer cells by up-reg ulating Notch and NF- κ B signaling pathways
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Internal radiation therapy for better response in mCRC
Patients with metastatic colorectal cancer with greater baseline liver tumour burden (≥12%), who were treated with the combination of mFOLFOX6 and selective internal radiation therapy SIR-Spheres Y-90 resin treatment, experience a statistically… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29Jufsu via IFTTT
Incontinentia Pigmenti with Persistent Hypercalcemia: Case Report
Abstract Incontinentia pigmenti (IP) is an X-linked dominant disorder that in most cases is considered lethal in males. IP affects the skin, hair, teeth, nails, eyes, and central nervous system. We report a case of persistent hypercalcemia (10.6–11.3 mg/dL) in a 19-month-old Caucasian boy with clinical IP. The proposed mechanism for his hypercalcemia is discussed.… Continue reading Incontinentia Pigmenti with Persistent Hypercalcemia: Case Report
Progression of Idiopathic Eruptive Macular Pigmentation in a Girl from Childhood to Adolescence: Case Report and Literature Review
Abstract A 14-year-old girl developed brownish round macules and patches over the face, trunk, and proximal limbs with extensive progression since she was 7 years old. Electron microscopy examination revealed an increase in the number and maturity of melanosomes in basal and suprabasal keratinocytes, although the number of melanocytes was within the normal range. A… Continue reading Progression of Idiopathic Eruptive Macular Pigmentation in a Girl from Childhood to Adolescence: Case Report and Literature Review
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
New England Journal of Medicine, Ahead of Print. http://ift.tt/29QfoMe from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29JrRSu via IFTTT
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