The Effect of Influenza Virus on The Metabolism of Peripheral Blood Mononuclear Cells with Metabolomics Approach

alexandrossfakianakis shared this article with you from Inoreader The Effect of Influenza Virus on The Metabolism of Peripheral Blood Mononuclear Cells with Metabolomics Approach Via Journal of Medical Virology Abstract Respiratory viruses led to many deaths and hospitalization per year in the world. Influenza virus is one of the most important respiratory viruses. Recently, the metabolic studies in viral infections have been widely considered by scientists. Metabolomics states the metabolites present in a living organism under certain conditions. In this study, peripheral blood mononuclear cells were spinoculated using virus produced by the Madin-Darby Canine Kidney cell culture system and cells were harvested following spinoculation by influenza virus. Isolation of peripheral blood mononuclear cells was performed by Ficoll-Paque density gradient centrifugation. Metabolites were extracted using organic and Water approaches. Metabolic profiling was performed by a non-targeted using LC-MS/MS technique. Multivariate analysis methods used to determine the main variables. the metabolic pathways involved were determined using databases. Results of present study showed change in biosynthesis pathways such as lipids, polyamines, catecholamines and vitamins. Findings also showed that it is possible to explain the process of inflammation caused by the influenza virus by studying the metabolism of immune cells. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Perceptions of NZ orthodontists and periodontists on the management of gingival recession in orthodontic patients

alexandrossfakianakis shared this article with you from Inoreader Perceptions of NZ orthodontists and periodontists on the management of gingival recession in orthodontic patients Via Australian Dental Journal ABSTRACT Background This study aimed to investigate the perceptions and opinions of orthodontists and periodontists on the management of gingival recession in orthodontic patients. Methods An online survey was sent to 29 periodontists and 80 orthodontists registered and currently practising in New Zealand. All participants answered questions about the timing and clinical indications of mucogingival surgeries in orthodontic patients diagnosed with mucogingival deformities. Results Most periodontists and orthodontists believed that gingival grafts should ideally be performed after orthodontic treatment. In clinical practice, 40% of periodontists indicated that they would receive referrals after completion of orthodontic treatment. However, 29.6% of orthodontists indicated that they would refer to a periodontist before orthodontic treatment in clinical practice. The most crucial factor that affected periodontists' decision making was 'evidence-based guidelines' (35.0%), followed by 'clinical experience' (30.0%) and 'patient concerns' (15.0%). All four factors of 'gingival phenotype', 'presence of gingival recession', 'amount of keratinised tissue' and 'planning specific tooth movements' were equally considered by orthodontists regarding their decision-making. Conclusions The majority of the surveyed New Zealand periodontists and orthodontists expressed a belief that the ideal timing for the management of gingival recessions would be after the completion of orthodontic treatment. © 2022 Australian Dental Association. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Identification of non-synonymous variations in ROBO1 and GATA5 genes in a family with bicuspid aortic valve disease

alexandrossfakianakis shared this article with you from Inoreader Identification of non-synonymous variations in <i>ROBO1</i> and <i>GATA5</i> genes in a family with bicuspid aortic valve disease Via Journal of Human Genetics - Issue - nature.com science feeds Journal of Human Genetics, Published online: 09 May 2022; doi:10.1038/s10038-022-01036-x Identification of non-synonymous variations in ROBO1 and GATA5 genes in a family with bicuspid aortic valve disease View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Avoidance of cutaneous adverse drug reactions induced by antiepileptic drugs based on pharmacogenomics

alexandrossfakianakis shared this article with you from Inoreader Avoidance of cutaneous adverse drug reactions induced by antiepileptic drugs based on pharmacogenomics Via Journal of Human Genetics - Issue - nature.com science feeds Journal of Human Genetics, Published online: 09 May 2022; doi:10.1038/s10038-022-01040-1 Avoidance of cutaneous adverse drug reactions induced by antiepileptic drugs based on pharmacogenomics View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Particulate matter (PM10) induces in vitro activation of human neutrophils, and lung histopathological alterations in a mouse model

alexandrossfakianakis shared this article with you from Inoreader Particulate matter (PM10) induces in vitro activation of human neutrophils, and lung histopathological alterations in a mouse model Via Earth and environmental sciences : nature.com subject feeds View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.