STAT5 is a key regulator in NK cells and acts as molecular switch from tumor surveillance to tumor promotion [Research Articles]
STAT5 is a key regulator in NK cells and acts as molecular switch from tumor surveillance to tumor promotion [Research Articles]: Natural Killer (NK) cells are tightly regulated by the JAK-STAT signaling pathway and cannot survive in the absence of STAT5. We now report that STAT5-deficient NK cells can be rescued by overexpression of Bcl-2. Our experiments define STAT5 as a master regulator of NK-cell proliferation and lytic functions. While NK cells are generally responsible for killing tumor cells, the rescued STAT5-deficient NK cells promote tumor formation by producing enhanced...περισσότερα »
Long-term outcomes of a phase II randomized controlled trial comparing intensity-modulated radiotherapy with or without weekly cisplatin for the treatment of locally recurrent nasopharyngeal carcinoma
Long-term outcomes of a phase II randomized controlled trial comparing intensity-modulated radiotherapy with or without weekly cisplatin for the treatment of locally recurrent nasopharyngeal carcinoma: Ying Guan†, Shuai Liu†, Han-Yu Wang, Ying Guo, Wei-Wei Xiao, Chun-Yan Chen, Chong Zhao, Tai-Xiang Lu and Fei HanEmail author †Contributed equally Chinese Journal of Cancer201635:20 DOI: 10.1186/s40880-016-0081-7© Guan et al. 2016 Received: 10 March 2015Accepted: 1 September 2015Published: 15 February 2016 Abstract Background Salvage treatment for locally recurrent nasophar...περισσότερα »
Radiation recall dermatitis induced by sorafenib
Radiation recall dermatitis induced by sorafenib: Abstract BackgroundRadiation recall dermatitis (RRD) is an acute inflammatory reaction confined to previously irradiated skin, mainly subsequent to the administration of certain chemotherapeutics. Here we present a rare case of RRD induced by the oral multikinase inhibitor sorafenib. Case reportA 77-year-old male with hepatocellular carcinoma was irradiated at ten different sites for bone metastases with 20–36 Gray in 5–12 fractions from January to March 2015. Sorafenib 400 mg was administered twice daily from mid-March. One wee...περισσότερα »
Benefits of stereotactic ablative radiotherapy combined with incomplete transcatheter arterial chemoembolization in hepatocellular carcinoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
This study aimed to evaluate the effect of stereotactic ablative radiotherapy (SABR) after incomplete transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1QvtBbj via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Association of oesophageal radiation dose volume metrics, neutropenia and acute radiation oesophagitis in patients receiving chemoradiotherapy for non-small cell lung cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
The relationship between oesophageal radiation dose volume metrics and dysphagia in patients having chemoradiation (CRT) for non-small cell lung cancer (NSCLC) is well established. There is also some evidence … from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1Ukd0NO via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Status quo and directions in deep head and neck hyperthermia
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
The benefit of hyperthermia as a potent modifier of radiotherapy has been well established and more recently also the combination with chemotherapy was shown beneficial. Also for head and neck cancer, the impa… from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1oz1ku9 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
Ultraviolet light (UV) is an important risk factor for cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin. These cancers most commonly affect persons with fair… from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/21ceijc via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Head & Face Medicine reviewer acknowledgement 2015
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
The editors of Head & Face Medicine would like to thank all reviewers who have contributed their time and expertise to the journal in Volume 11 (2015). from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/20SG66D via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Use of modified lateral upper arm free flap for reconstruction of soft tissue defect after resection of oral cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
To evaluate the suitability of a modified lateral upper arm free flap (LAFF) for reconstruction of soft tissue defects after resection of oral cancer. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1L8Dy2t via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Expression of cell adhesion molecule CD44 in mucoepidermoid carcinoma and its association with the tumor behavior
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
The most common malignant salivary gland tumors that affect both adult and children is mucoepidermoid carcinoma. It usually affects both minor and major salivary glands but parotid gland is considering the mos… from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1L8Dvnj via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Precision of fibula positioning guide in mandibular reconstruction with a fibula graft
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
This study examined the usefulness of the fibula positioning guide for boosting the accuracy of mandible reconstructions. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1p0nbLy via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
Despite recent advances in oral squamous cell carcinoma (OSCC) diagnosis and therapy, disease recurrence remains common and is strongly associated with mortality. It is therefore critical to identify new targe… from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1T3TSEv via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
UHRF1 overexpression is involved in cell proliferation and biochemical recurrence in prostate cancer after radical prostatectomy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό
Biochemical recurrence (BCR) is widely used to define the treatment success and to make decisions on if or how to initiate a secondary therapy, but uniform criteria to define BCR after radical prostatectomy (R… from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1Qvxm0w via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma
Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma: Xiaodong Feng†, Yuchen Jiang†, Liang Xie†, Lu Jiang†, Jing Li, Chongkui Sun, Hao Xu, Ruinan Wang, Min Zhou, Yu Zhou, Hongxia Dan, Zhiyong Wang, Ning Ji, Peng Deng, Ga Liao, Ning Geng, Yun Wang, Dunfang Zhang, Yunfeng Lin, Ling Ye, Xinhua Liang, Longjiang Li, Gang Luo, Mingye Feng, Juan Fang, Xin Zeng†Email author, Zhi WangEmail author and Qianming Chen †Contributed equally Journal of Experimental & Clinical Cancer Research201635:35 DOI: 10.1186/s13046-016-0309-z© Feng... περισσότερα »
Deep head and neck hyperthermia
Status quo and directions in deep head and neck hyperthermia: Margarethus M. PaulidesEmail authorView ORCID ID profile, Gerda M. Verduijn and Netteke Van Holthe Radiation Oncology201611:21 DOI: 10.1186/s13014-016-0588-8© Paulides et al. 2016 Received: 9 September 2015Accepted: 13 January 2016Published: 11 February 2016 Abstract The benefit of hyperthermia as a potent modifier of radiotherapy has been well established and more recently also the combination with chemotherapy was shown beneficial. Also for head and neck cancer, the impact of hyperthermia has been clinically d... περισσότερα »
Association of oesophageal radiation dose volume metrics, neutropenia and acute radiation oesophagitis in patients receiving chemoradiotherapy for non-small cell lung cancer
Association of oesophageal radiation dose volume metrics, neutropenia and acute radiation oesophagitis in patients receiving chemoradiotherapy for non-small cell lung cancer Sarah Everitt, Mary Duffy, Mathias Bressel, Belinda McInnes, Christine Russell, Tim Sevitt and David BallEmail authorView ORCID ID profile Radiation Oncology201611:20 DOI: 10.1186/s13014-016-0596-8© Everitt et al. 2016 Received: 22 October 2015Accepted: 1 February 2016Published: 11 February 2016 Abstract Introduction The relationship between oesophageal radiation dose volume metrics and dysphagia in ... περισσότερα »
Cutaneous Manifestations in Neuro-Oncology
: Clinically Relevant Tumor and Treatment Associated Dermatologic Findings via Seminars in Oncology Publication date: Available online 23 February 2016 *Source:*Seminars in Oncology Author(s): Roy E. Strowd, Lindsay C. Strowd, Jaishri O. Blakeley Skin findings are a rare but important aspect of the evaluation and management of patients with tumors of the nervous system. Skin findings have the highest prevalence in genetic tumor syndromes termed neuro-genodermatoses which include neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and tuberous sclerosis. Skin changes are obs... περισσότερα »
Skin Manifestations of Endocrine and Neuroendocrine Tumors
Skin Manifestations of Endocrine and Neuroendocrine Tumors via Seminars in Oncology Publication date: Available online 23 February 2016 *Source:*Seminars in Oncology Author(s): Jonathan S. Leventhal, Irwin M. Braverman The skin signs of benign and malignant endocrine and neuroendocrine tumors are manifold and early identification of these dermatologic features is crucial in initiating timely diagnosis and management. This article reviews the salient cutaneous features of these tumors that arise in the classic endocrine glands, lung and gastrointestinal tract either as individual neopla... περισσότερα »
Platelet rich clots are resistant to lysis by thrombolytic therapy in a rat model of embolic stroke
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Early recanalization of occluded vessels in stroke is closely associated with improved clinical outcome. Microbubble-enhanced sonothrombolysis is a promising therapy to improve recanalization rates and reduce … from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VBvV4V via IFTTT
Report on the 6th scientific meeting of the “Verein zur Förderung des Wissenschaftlichen Nachwu chses in der Neurologie” (NEUROWIND e.V.) held in Motzen, Germany, Oct. 31th – Nov. 2nd, 2014
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
From October 31th – November 2nd, 2014, the 6th NEUROWIND e.V. meeting was held in Motzen, Brandenburg, Germany. 70 doctoral students and postdocs from over 25 different groups working in German and Swiss univ… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QA43A8 via IFTTT
Flow cytometric characterization of brain dendritic cell subsets after murine stroke
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 4 δευτερόλεπτα
Sterile inflammation is a substantial element of post-stroke pathophysiology with the determination of autoimmunity versus tolerance being one of its most important aspects. It is believed that this determinat… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VBvXKi via IFTTT
Assessment of iodine status among pregnant women in a rural community in ghana – a cross sectional study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 4 δευτερόλεπτα
Pregnancy is associated with parallel increase in both iodine, and thyroid hormone requirements suggesting that, there may be the need for additional iodine intake during this period to prevent potential iodin… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QA41bs via IFTTT
Prevalence of herbal medicine use and associated factors among pregnant women attending antenatal care at public health facilities in Hossana Town, Southern Ethiopia: facility based cross sectional study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 4 δευτερόλεπτα
The use of herbal medicine has been on increase in many developing and industrialized countries. More pregnant women use herbal remedies to treat pregnancy related problems due to cost-effectiveness of therapy… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VBvUhD via IFTTT
Prevalence of human papilloma virus (HPV) and its genotypes in cervical specimens of Egyptian women by linear array HPV genotyping test
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 4 δευτερόλεπτα
The association of human papillomavirus (HPV) with cervical cancer is well established. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XKe6lM via IFTTT
Infectious Agents and Cancer reviewer acknowledgement 2015
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 4 δευτερόλεπτα
The editors of Infectious Agents and Cancer would like to thank all our reviewers who have contributed their time and expertise to the journal in Volume 10 (2015). from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SQ5EC5 via IFTTT
Patterns of human herpesvirus-8 oral shedding among diverse cohorts of human herpesvirus-8 seropositive persons
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 4 δευτερόλεπτα
Human herpesvirus-8 (HHV-8), the etiologic agent of Kaposi sarcoma (KS), establishes lifelong latent infection with periodic lytic replication (“shedding”) at mucosal sites, especially the oropharynx. Patterns… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XKe3qa via IFTTT
Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 4 δευτερόλεπτα
Ultraviolet light (UV) is an important risk factor for cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin. These cancers most commonly affect persons with fair… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21ceijc via IFTTT
Head & Face Medicine reviewer acknowledgement 2015
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 4 δευτερόλεπτα
The editors of Head & Face Medicine would like to thank all reviewers who have contributed their time and expertise to the journal in Volume 11 (2015). from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/20SG66D via IFTTT
Cutaneous Manifestations and Management of Hematologic Neoplasms
Cutaneous Manifestations and Management of Hematologic Neoplasms via Seminars in Oncology Publication date: Available online 23 February 2016 *Source:*Seminars in Oncology Author(s): Olalekan O. Oluwole, John A. Zic, Jonathan J. Douds, Mary Ann Thompson, John P. Greer Many malignant hematologic neoplasms can directly and indirectly involve the skin with lesions that are disfiguring, painful, and compromise integumentary function. The majority of lymphomas that directly infiltrate the skin are of T cell origin but B cell lymphomas, and others hematologic neoplasms including acute myeloi... περισσότερα »
The Cutaneous Manifestations of Gastrointestinal Malignancy
The Cutaneous Manifestations of Gastrointestinal Malignancy via Seminars in Oncology Publication date: Available online 23 February 2016 *Source:*Seminars in Oncology Author(s): Courtney R. Schadt The skin is often the herald of an underlying systemic illness, and gastrointestinal malignancies can present in numerous ways in the skin. Paraneoplastic phenomenon, such as acanthosis nigricans and tripe palm, may be the first indicator of a gastrointestinal malignancy. In addition, gastrointestinal cancers can metastasize to the skin, as described in the well-known Sister Mary Joseph’s nod...περισσότερα »
The occlusion tests and end-expiratory esophageal pressure: measurements and comparison in controlled and assisted ventilation
Esophageal pressure is used as a reliable surrogate of the pleural pressure. It is conventionally measured by an esophageal balloon placed in the lower part of the esophagus. To validate the correct position … from #Medicine via ola Kala on Inoreader http://ift.tt/1QA1Q7X via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader… Continue reading The occlusion tests and end-expiratory esophageal pressure: measurements and comparison in controlled and assisted ventilation
Factors associated with initiation of medical advanced cardiac life support after out-of-hospital cardiac arrest
Termination of resuscitation rule permits to stop futile resuscitative efforts by paramedics. In a different setting, the decision to withhold resuscitation by emergency physician could be based on different f… from #Medicine via ola Kala on Inoreader http://ift.tt/1oEKQBg via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Osg03l via IFTTT
Osimertinib Western and Asian clinical pharmacokinetics in patients and healthy volunteers: implications for formulation, dose, and dosing frequency in pivotal clinical studies
Abstract Purpose Osimertinib (AZD9291) 80 mg once daily is approved by the US FDA for the treatment of patients with metastatic EGFR T790M-positive NSCLC whose disease has previously progressed on EGFR-TKI therapy. Osimertinib PK was evaluated to define the dose and dosing interval, whether a fixed-dosing approach can be used globally, and the impact of… Continue reading Osimertinib Western and Asian clinical pharmacokinetics in patients and healthy volunteers: implications for formulation, dose, and dosing frequency in pivotal clinical studies
Developmental anomalies of the distal vertebral artery and posterior inferior cerebellar artery: diagnosis by CT angiography and literature review
Developmental anomalies of the distal vertebral artery and posterior inferior cerebellar artery: diagnosis by CT angiography and literature review: Abstract Purpose The aim of this study was to identify variations in the anatomy of the distal vertebral artery (VA) and posterior inferior cerebellar artery (PICA) with computed tomography (CT) angiography. Methods CT angiography was performed… Continue reading Developmental anomalies of the distal vertebral artery and posterior inferior cerebellar artery: diagnosis by CT angiography and literature review
Dependence and a Kantian conception of dignity as a value
Abstract Kantian moral concepts concerning respect for human dignity have played a central role in articulating ethical guidelines for medical practice and research, and for articulating some central positions within bioethical debates more generally. The most common of these Kantian moral concepts is the obligation to respect the dignity of patients and of human research… Continue reading Dependence and a Kantian conception of dignity as a value
Fragility, uncertainty, and healthcare
Abstract Medicine seeks to overcome one of the most fundamental fragilities of being human, the fragility of good health. No matter how robust our current state of health, we are inevitably susceptible to future illness and disease, while current disease serves to remind us of various frailties inherent in the human condition. This article examines… Continue reading Fragility, uncertainty, and healthcare
Haematological and acute-phase response of skin Pseudomonas aeruginosa infection to treatment with antibiotic and parthenolide
Haematological and acute-phase response of dogs with experimental skin Pseudomonas aeruginosa infection to treatment with antibiotic and parthenolide: Abstract Changes in white blood cells, leukogram patterns, the positive acute-phase protein (APP) fibrinogen and negative APPs (albumin and arylesterase) were monitored to evaluate their potential as sensitive indicators throughout the course of therapy in canine skin… Continue reading Haematological and acute-phase response of skin Pseudomonas aeruginosa infection to treatment with antibiotic and parthenolide
Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation
Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation Ja Seong Bae, Yourha Kim, Sora Jeon, Se Hee Kim, Tae Jung Kim, Sohee Lee, Min-Hee Kim, Dong Jun Lim, Youn Soo Lee and Chan Kwon JungEmail author Diagnostic Pathology201611:21 DOI: 10.1186/s13000-016-0458-6© Bae… Continue reading Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation
Benefits of taking the natural pigment astaxanthin
New light shed on neurogenesis in the hippocampus and the molecular basis for the promotion of spatial memory capacity. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/24n6PNc via IFTTT
Mandibular Fractures
Mechanics in the Production of Mandibular Fractures: A Clinical, Retrospective Case-Control Study: by Haihua Zhou, Kun Lv, Rongtao Yang, Zhi Li, Zubing Li As the mandible is susceptible to fracture, the aim of this study was to use multivariate logistic regression analysis to identify and distinguish various internal factors that may influence the location of… Continue reading Mandibular Fractures
Cutaneous Manifestations Associated with Melanoma
Cutaneous Manifestations Associated with Melanoma via Seminars in Oncology Publication date: Available online 23 February 2016 *Source:*Seminars in Oncology Author(s): Ritva Vyas, Jacqueline Selph, Meg R. Gerstenblith Melanoma is a malignancy most commonly arising from the skin; therefore, primary melanoma characteristics are usually the first cutaneous manifestations of melanoma. Cutaneous metastases, which can occur locally or diffusely, are important to detect in a timely manner as treatments for advanced melanoma that impact survival are now available. Melanoma can be associated wi... περισσότερα »
Cutaneous Manifestations of Non-Targeted and Targeted Chemotherapies
Cutaneous Manifestations of Non-Targeted and Targeted Chemotherapies via Seminars in Oncology Publication date: Available online 23 February 2016 *Source:*Seminars in Oncology Author(s): Veronica J. Shi, Lauren L. Levy, Jennifer N. Choi Care of the oncologic patient requires an integral understanding of the adverse reactions of chemotherapy. With the advent of targeted agents and immunomodulating therapies, reactions to these newer treatments are of clinical interest. Cutaneous side effects of chemotherapeutic agents, including toxic erythema and mucositis, are common and may require c... περισσότερα »
Soft Tissue Sarcomas in Skin
: Presentations and Management via Seminars in Oncology Publication date: Available online 23 February 2016 *Source:*Seminars in Oncology Author(s): Joshua C. Patt, Nikkole Haines Soft tissue sarcomas are a rare but heterogeneous family of malignant tumors that are predominantly found deep to the integumentary layer. Only a small number of these primary mesenchymal tumors actually originate from the dermal layers. A systematic approach to the evaluation and workup of these neoplasms can prevent inappropriate management. After staging evaluation, most of these tumors are primarily manag... περισσότερα »
Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face
Ultraviolet light (UV) is an important risk factor for cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin. These cancers most commonly affect persons with fair... from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/21ceijc via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Head & Face Medicine reviewer acknowledgement 2015
The editors of Head & Face Medicine would like to thank all reviewers who have contributed their time and expertise to the journal in Volume 11 (2015). from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/20SG66D via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Use of modified lateral upper arm free flap for reconstruction of soft tissue defect after resection of oral cancer
To evaluate the suitability of a modified lateral upper arm free flap (LAFF) for reconstruction of soft tissue defects after resection of oral cancer. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1L8Dy2t via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Expression of cell adhesion molecule CD44 in mucoepidermoid carcinoma and its association with the tumor behavior
The most common malignant salivary gland tumors that affect both adult and children is mucoepidermoid carcinoma. It usually affects both minor and major salivary glands but parotid gland is considering the mos... from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1L8Dvnj via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Precision of fibula positioning guide in mandibular reconstruction with a fibula graft
This study examined the usefulness of the fibula positioning guide for boosting the accuracy of mandible reconstructions. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1p0nbLy via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Cutaneous Squamous Cell Carcinomas in Solid Organ Transplant Recipients
: Emerging Strategies for Surveillance, Staging, and Treatment via Seminars in Oncology Publication date: Available online 23 February 2016 *Source:*Seminars in Oncology Author(s): Changhyun Kim, Joyce Cheng, Oscar R. Colegio The incidence of cutaneous squamous cell carcinomas in immunosuppressed solid organ transplant recipients is 65- to 250-fold greater than in the general population. In addition, squamous cell carcinoma in solid organ transplant recipients is more aggressive than in the general population. Solid organ transplant recipients must undergo skin cancer screenings at int...περισσότερα »
Experiences and perspectives of patients with post-polio syndrome and therapists with exercise and cognitive behavioural therapy
Many persons affected with poliomyelitis develop post-polio syndrome (PPS) later in their life. Recently, the effectiveness of Exercise Therapy (ET) and Cognitive Behavioural Therapy (CBT) for PPS has been eva... from Neurology via xlomafota13 on Inoreader http://ift.tt/1oz0vRO via IFTTT
Comorbid epilepsy in Finnish patients with adult-onset Huntington’s disease
Seizures are common in juvenile Huntington's disease (HD), but considered to be rare in adult-onset HD. We studied the occurrence of epilepsy and seizures in a nationwide cohort of Finnish patients with adult-... from Neurology via xlomafota13 on Inoreader http://ift.tt/21ccZAK via IFTTT
Late-onset spinal form xanthomatosis without brain lesion: a case report
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive sterol storage disease caused by a mutated sterol 27-hydroxylase (CYP27A1) gene. Patients with typical CTX show neurological dysfunction inclu... from Neurology via xlomafota13 on Inoreader http://ift.tt/1oz0u0s via IFTTT
Diagnosis of TIA (DOT) score – design and validation of a new clinical diagnostic tool for transient ischaemic attack
The diagnosis of Transient Ischaemic Attack (TIA) can be difficult and 50–60 % of patients seen in TIA clinics turn out to be mimics. Many of these mimics have high ABCD2 scores and fill urgent TIA clinic slot... from Neurology via xlomafota13 on Inoreader http://ift.tt/21ccYNe via IFTTT
Randomised controlled trial to evaluate the efficacy and usability of a computerised phone-based lifestyle coaching system for primary and secondary prevention of stroke
One of the most effective current approaches to preventing stroke events is the reduction of lifestyle risk factors, such as unhealthy diet, physical inactivity and smoking. In this study, we assessed the effi... from Neurology via xlomafota13 on Inoreader http://ift.tt/1oz0u0c via IFTTT
Prediction of awakening from hypothermic post anoxic coma based on auditory discrimination
[image: cover.gif?v=1&s=e99e5c526ce60b1743393079] Abstract Objective: Most of the available clinical tests for prognosis of post-anoxic coma are informative of poor outcome. Previous work has shown that an improvement in auditory discrimination over the first days of coma is predictive of awakening. Here, we aimed at evaluating this test on a large cohort of patients undergoing therapeutic hypothermia and at investigating its added value on existing clinical measures. Methods: We recorded electroencephalography responses to auditory stimuli in 94 comatose patients, under hypother... περισσότερα »
Cutaneous Manifestations of .....
Cutaneous Manifestations of Multiple Myeloma and Other Plasma Cell Proliferative Disorders via Seminars in Oncology Publication date: Available online 23 February 2016 *Source:*Seminars in Oncology Author(s): Manisha Bhutani, Zainab Shahid, Alicia Schnebelen, Daisy Alapat, Saad Z. Usmani Plasma cell proliferative disorders cause rare but extremely varied dermatologic manifestations that may occur as an accompaniment to established diagnoses, or may be a first clue of an underlying neoplasm in the setting of clinical suspicion. In some instances skin lesions result from aggregation of ...περισσότερα »
New nodes and edges in the glucosinolate molecular network revealed by proteomics and metabolomics of Arabidopsis myb28/29 and cyp79B2/B3 glucosinolate mutants
Publication date: Available online 23 February 2016 *Source:*Journal of Proteomics Author(s): Islam Mostafa, Ning Zhu, Mi-Jeong Yoo, Kelly M. Balmant, Biswapriya B. Misra, Craig Dufresne, Maged Abou-Hashem, Sixue Chen, Maher El-Domiaty Glucosinolates present in Brassicales are important for human health and plant defense against insects and pathogens. Here we investigate the proteomes and metabolomes of Arabidopsis myb28/29 and cyp79B2/B3 mutants deficient in aliphatic glucosinolates and indolic glucosinolates, respectively. Quantitative proteomics of the myb28/29 and cyp79B2/B3 mu... περισσότερα »
Opportunities for wheat proteomics to discover the biomarkers for respiration-dependent biomass production, stress tolerance and cytoplasmic male sterility
Publication date: Available online 23 February 2016 *Source:*Journal of Proteomics Author(s): Richard P. Jacoby, A. Harvey Millar, Nicolas L. Taylor Wheat has served as a key species for characterising fundamental aspects of mitochondrial biochemistry and respiratory physiology. Respiratory traits are linked to many important agronomic properties, so identifying the proteins that carry out these molecular processes would define a new set of targets for wheat breeding. To date, systematic proteomic investigations into wheat mitochondria have lagged behind other species, due to the siz...περισσότερα »
iTRAQ-based comparative proteomic analysis of excretory–secretory proteins of schistosomula and adult worms of Schistosoma japonicum
Publication date: Available online 23 February 2016 *Source:*Journal of Proteomics Author(s): Xiaodan Cao, Zhiqiang Fu, Min Zhang, Yanhui Han, Hongxiao Han, Qian Han, Ke Lu, Yang Hong, Jiaojiao Lin Schistosomiasis remains a serious public health problem with 200 million people infected and 779 million people at risk worldwide. The schistosomulum and adult worm are two stages of the complex lifecycle of Schistosoma japonicum and excretory/secretory proteins (ESPs) play a major role in host–parasite interactions. In this study, iTRAQ-coupled LC–MS/MS was used to investigate the proteo...περισσότερα »
Energy expenditure in critically ill patients estimated by population-based equations, indirect calorimetry and CO2-based indirect calorimetry
Indirect calorimetry (IC) is the reference method for measurement of energy expenditure (EE) in mechanically ventilated critically ill patients. When IC is unavailable, EE can be calculated by predictive equat... from #Medicine via ola Kala on Inoreader http://ift.tt/1WG5xai via IFTTT
Hemodynamic monitoring in the era of digital health
Digital innovations are changing medicine, and hemodynamic monitoring will not be an exception. Five to ten years from now, we can envision a world where clinicians will learn hemodynamics with simulators and ... from #Medicine via ola Kala on Inoreader http://ift.tt/1KGN0Kh via IFTTT
Experts’ recommendations for the management of cardiogenic shock in children
Cardiogenic shock which corresponds to an acute state of circulatory failure due to impairment of myocardial contractility is a very rare disease in children, even more than in adults. To date, no internationa... from #Medicine via ola Kala on Inoreader http://ift.tt/1WG5ziA via IFTTT
The occlusion tests and end-expiratory esophageal pressure: measurements and comparison in controlled and assisted ventilation
Esophageal pressure is used as a reliable surrogate of the pleural pressure. It is conventionally measured by an esophageal balloon placed in the lower part of the esophagus. To validate the correct position ... from #Medicine via ola Kala on Inoreader http://ift.tt/1QA1Q7X via IFTTT
Factors associated with initiation of medical advanced cardiac life support after out-of-hospital cardiac arrest
Termination of resuscitation rule permits to stop futile resuscitative efforts by paramedics. In a different setting, the decision to withhold resuscitation by emergency physician could be based on different f... from #Medicine via ola Kala on Inoreader http://ift.tt/1oEKQBg via IFTTT
Developmental anomalies of the distal vertebral artery and posterior inferior cerebellar artery: diagnosis by CT angiography and literature review
Developmental anomalies of the distal vertebral artery and posterior inferior cerebellar artery: diagnosis by CT angiography and literature review: Abstract PurposeThe aim of this study was to identify variations in the anatomy of the distal vertebral artery (VA) and posterior inferior cerebellar artery (PICA) with computed tomography (CT) angiography. MethodsCT angiography was performed at two hospitals. And the results were analyzed for VA anomalies. ResultsSeven of the 3067 patients who received brain CT angiography in first hospital had seven intracranial VA fenestratio... περισσότερα »
Haematological and acute-phase response of skin Pseudomonas aeruginosa infection to treatment with antibiotic and parthenolide
Haematological and acute-phase response of dogs with experimental skin Pseudomonas aeruginosa infection to treatment with antibiotic and parthenolide: AbstractChanges in white blood cells, leukogram patterns, the positive acute-phase protein (APP) fibrinogen and negative APPs (albumin and arylesterase) were monitored to evaluate their potential as sensitive indicators throughout the course of therapy in canine skin *Pseudomonas aeruginosa* infection. The study was performed on 15 male mixed-breed dogs, divided in three groups of 5 dogs each. Dogs from group A were injected subcuta...περισσότερα »
Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation
Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation Ja Seong Bae, Yourha Kim, Sora Jeon, Se Hee Kim, Tae Jung Kim, Sohee Lee, Min-Hee Kim, Dong Jun Lim, Youn Soo Lee and Chan Kwon JungEmail author Diagnostic Pathology201611:21 DOI: 10.1186/s13000-016-0458-6© Bae et al. 2016 Received: 5 September 2015Accepted: 14 January 2016Published: 9 February 2016 Abstract Background Mutations in the TERT promoter, ALK rearrangement, and the BRAF V600E mutation are associated with aggressive clinic... περισσότερα »
Mandibular Fractures
Mechanics in the Production of Mandibular Fractures: A Clinical, Retrospective Case-Control Study: by Haihua Zhou, Kun Lv, Rongtao Yang, Zhi Li, Zubing Li As the mandible is susceptible to fracture, the aim of this study was to use multivariate logistic regression analysis to identify and distinguish various internal factors that may influence the location of mandibular fractures. The study included 1131 patients with maxillofacial fractures during the period from January 2000 to December 2009 to evaluate the association of mandibular fracture location (unilateral symphysis, body, ... περισσότερα »
Increased airway pressure due to superior mediastinal hematoma during endovascular coiling by transcarotid approach
Increased airway pressure due to superior mediastinal hematoma during endovascular coiling by transcarotid approach: [image: article_notepad.gif] An elderly woman with subarachanoid hemorrhage presented to our interventional neuroradiology suite for coil embolization of multiple intracranial aneurysms. The patient had difficult vascular access for the passage of microcatheter; hence, the embolization procedure was carried out with direct puncture of the left common carotid artery. During the procedure, the patient developed thromboembolism which was treated by administration of an... περισσότερα »
A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17 + cell frequency
A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17 + cell frequency: AbstractPatients with HPV-positive oropharyngeal squamous cell carcinomas (OPSCCs) have a better prognosis than patients with non-HPV-induced OPSCC. The role of the immune response in this phenomenon is yet unclear. We studied the number of T cells, regulatory T cells (Tregs), T helper 17 (Th17) cells and IL-17+ non-T cells (mainly granulocytes) in matched HPV-positive and HPV-negative OPSCC cases (*n* = 162). Furthermore, the production of ...περισσότερα »
Cross-Reactivity among Beta-Lactams
Cross-Reactivity among Beta-Lactams: AbstractPenicillins and cephalosporins are the major classes of beta-lactam (BL) antibiotics in use today and one of the most frequent causes of hypersensitivity reactions to drugs. Monobactams, carbapenems, oxacephems, and beta-lactamase inhibitors constitute the four minor classes of BLs. This review takes into account mainly the prospective studies which evaluated cross-reactivity among BLs in subjects with a well-demonstrated hypersensitivity to a certain class of BLs by performing allergy tests with alternative BLs and, in case of negative ...περισσότερα »
Allergy to pets
Epidemiologia i przebieg naturalny alergii na zwierzęta futerkowe via Alergologia Polska - Polish Journal of Allergology Publication date: Available online 23 February 2016 *Source:*Alergologia Polska - Polish Journal of Allergology Author(s): Natalia Ukleja-Sokołowska, Zbigniew Bartuzi Researchers agree that the incidence of allergy to pets in Europe and the United States is growing for several decades. The incidence of allergy to dog and cat varies depending on the chosen population, age and sex.The number of pets in the environment makes it difficult to avoid contact with them. Aller...περισσότερα »
Methotrexate and its therapeutic antagonists, caffeine and theophylline, target a motogenic T-cell mechanism driven by thrombospondin-1 (TSP-1)
Methotrexate and its therapeutic antagonists, caffeine and theophylline, target a motogenic T-cell mechanism driven by thrombospondin-1 (TSP-1): Methotrexate (MTX) is a widely used treatment for inflammatory diseases such as rheumatoid arthritis and psoriasis, based on the concept that it is immunosuppressive. Its mechanism of action, however, remains unclear, although it is thought to depend on adenosine. Caffeine and theophylline, which have several targets including adenosine receptors, have been shown to suppress the beneficial clinical effects of MTX. Here we show that MTX and...περισσότερα »
Primary immunodeficiency diseases (PIDs) : Unbiased targeted next-generation sequencing molecular approach
Unbiased targeted next-generation sequencing molecular approach for primary immunodeficiency diseases via Allergy and Clinical Immunology Publication date: Available online 23 February 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Hamoud Al-Mousa, Mohamed Abouelhoda, Dorota M. Monies, Nada Al-Tassan, Abdulaziz Al-Ghonaium, Bandar Al-Saud, Hasan Al-Dhekri, Rand Arnaout, Saleh Al-Muhsen, Nazema Ades, Sahar Elshorbagi, Sulaiman Al Gazlan, Farrukh Sheikh, Majed Dasouki, Lina El-Baik, Tanzeil Elamin, Amal Jaber, Omnia Kheir, Mohamed El-Kalioby, Shazia Subhani, Eman Al ... περισσότερα »
A preliminary investigation of daily variability of stuttering in adults
[image: S00219924.gif] Publication date: Available online 23 February 2016 *Source:*Journal of Communication Disorders Author(s): Christopher D. Constantino, Paula Leslie, Robert W. Quesal, J. Scott Yaruss PurposeVariability in frequency of stuttering has made the results of treatment outcome studies difficult to interpret. Many factors that affect variability have been investigated; yet the typical range of variability experienced by speakers remains unknown. This study examined the day-to-day variability in the percentage of syllables containing stuttered and nonstuttered disfluen... περισσότερα »
Benefits of taking the natural pigment astaxanthin
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
New light shed on neurogenesis in the hippocampus and the molecular basis for the promotion of spatial memory capacity. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/24n6PNc via IFTTT
Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Nature Neuroscience 19, 517 (2016). doi:10.1038/nn.4235 Authors: Derek J C Tai, Ashok Ragavendran, Poornima Manavalan, Alexei Stortchevoi, Catarina M Seabra, Serkan Erdin, Ryan L Collins, Ian Blumenthal, Xiaoli Chen, Yiping Shen, Mustafa Sahin, Chengsheng Zhang, Charles Lee, James F Gusella & Michael E Talkowski from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TwGzLl via IFTTT
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Nature Neuroscience 19, 420 (2016). doi:10.1038/nn.4228 Authors: Barbara Franke, Jason L Stein, Stephan Ripke, Verneri Anttila, Derrek P Hibar, Kimm J E van Hulzen, Alejandro Arias-Vasquez, Jordan W Smoller, Thomas E Nichols, Michael C Neale, Andrew M McIntosh, Phil Lee, Francis J McMahon, Andreas Meyer-Lindenberg, Manuel Mattheisen, Ole A Andreassen, Oliver Gruber, Perminder S Sachdev, […]
PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Nature Neuroscience 19, 454 (2016). doi:10.1038/nn.4231 Authors: Smitha Karunakaran, Ananya Chowdhury, Flavio Donato, Charles Quairiaux, Christoph M Michel & Pico Caroni from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TwGxmz via IFTTT
Separate circuitries encode the hedonic and nutritional values of sugar
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Nature Neuroscience 19, 465 (2016). doi:10.1038/nn.4224 Authors: Luis A Tellez, Wenfei Han, Xiaobing Zhang, Tatiana L Ferreira, Isaac O Perez, Sara J Shammah-Lagnado, Anthony N van den Pol & Ivan E de Araujo from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21nyA61 via IFTTT
Post-vaccination myositis and myocarditis in a previously healthy male
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
The immunological literature has been redefining clinical phenomena as hypotheses emerge regarding causal links between triggers, immunologic manifestations, and their specific inflammatory cascades. Of late, … from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Uk8GOA via IFTTT
Viruses, Vol. 8, Pages 57: Therapeutic Use of Native and Recombinant Enteroviruses
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Research on human enteroviruses has resulted in the identification of more than 100 enterovirus types, which use more than 10 protein receptors and/or attachment factors required in cell binding and initiation of the replication cycle. Many of these “viral” receptors are overexpressed in cancer cells. Receptor binding and the ability to replicate in specific target […]
Viruses, Vol. 8, Pages 55: Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus Strains
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Porcine epidemic diarrhea virus (PEDV), a member of Alphacoronavirus, has caused huge economic losses for the global pork industry recently. The spike (S) protein mediates PEDV entry into host cells. Herein, we investigated the interactions between the S protein and its receptor porcine aminopeptidase N (pAPN) or co-receptor sugars. The C-terminal domain (CTD) of the […]
Idelalisib treatment was well tolerated in patients with allergic rhinitis and appears to reduce allergic responses clinically and immunologically after an environmental allergen challenge.
Randomized phase 1 study of the phosphatidylinositol 3-kinase δ inhibitor idelalisib in patients with allergic rhinitis via Allergy and Clinical Immunology Publication date: Available online 23 February 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Friedrich Horak, Kamal D. Puri, Bart H. Steiner, Leanne Holes, Guan Xing, Petra Zieglmayer, René Zieglmayer, Patrick Lemell, Albert Yu BackgroundPhosphatidylinositol 3-kinase p110δ isoform (PI3K p110δ) activity is essential for mast cell activation, suggesting that inhibition of PI3K p110δ might be useful in treating all... περισσότερα »
Roflumilast combined with montelukast versus montelukast alone
as add-on treatment in patients with moderate-to-severe asthma via Allergy and Clinical Immunology Publication date: Available online 23 February 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Eric D. Bateman, Udo-Michael Goehring, Frank Richard, Henrik Watz BackgroundRoflumilast, a selective phosphodiesterase 4 inhibitor, has been shown to provide modest improvements in lung function in patients with mild-to-moderate asthma, but its efficacy in patients with moderate-to-severe asthma has not been assessed. We hypothesized that this drug might provide benefit if co...περισσότερα »
Mechanics in the Production of Mandibular Fractures: A Clinical, Retrospective Case-Control Study
by Haihua Zhou, Kun Lv, Rongtao Yang, Zhi Li, Zubing Li As the mandible is susceptible to fracture, the aim of this study was to use multivariate logistic regression analysis to identify and distinguish various internal factors that may influence the location of mandibular fractures. The study included 1131 patients with maxillofacial fractures during the period from January 2000 to December 2009 to evaluate the association of mandibular fracture location (unilateral symphysis, body, angle, condylar, or bilateral condylar fractures) with various internal factors. Among the 1131 pat... περισσότερα »
Aspirin-exacerbated respiratory disease : Nonsteroidal anti-inflammatory–induced inhibition of signal transducer and activator of transcription 6 (STAT-6) phosphorylation
Nonsteroidal anti-inflammatory–induced inhibition of signal transducer and activator of transcription 6 (STAT-6) phosphorylation in aspirin-exacerbated respiratory disease via Allergy and Clinical Immunology Publication date: Available online 23 February 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Rohit K. Katial, Michael Martucci, Trever Burnett, Anna Faino, Lindsay Finkas, Sucai Liu, Rafeul Alam BackgroundAspirin desensitization provides long-term clinical benefits. The exact mechanisms of aspirin desensitization are not clearly understood.ObjectiveWe sought t...περισσότερα »
Corrigendum to “The relationships between foot-joints range of motion and plantar pressure in the normal foot” [Gait Posture 42 (September (Suppl. 2)) (2015) S24]
Publication date: Available online 23 February 2016 *Source:*Gait & Posture Author(s): Paolo Caravaggi, Alberto Leardini, Claudia Giacomozzi from #Audiology via xlomafota13 on Inoreader http://ift.tt/1RYxUBl via IFTTT
Calibration of an instrumented treadmill using a precision-controlled device with artificial neural network-based error corrections
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Hong-Jung Hsieh, Hsiu-Chen Lin, Hsuan-Lun Lu, Ting-Yi Chen, Tung-Wu Lu Instrumented treadmills (ITs) are used to measure reaction forces (RF) and center of pressure (COP) movements for gait and balance assessment. Regular in situ calibration is essential to ensure their accuracy and to identify conditions when a factory re-calibration is needed. The current study aimed to develop and calibrate in situ an IT using a portable, precision-controlled calibration device with an artificial neural network (ANN)-base...περισσότερα »
Mitochondrial loss in airway epithelial cells : IL-4 promotes asymmetric dimethylarginine accumulation, oxo-nitrative stress, and hypoxic response–induced mitochondrial loss in airway epithelial cells
IL-4 promotes asymmetric dimethylarginine accumulation, oxo-nitrative stress, and hypoxic response–induced mitochondrial loss in airway epithelial cells via Allergy and Clinical Immunology Publication date: Available online 23 February 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Bijay Pattnaik, Manish Bodas, Naveen Kumar Bhatraju, Tanveer Ahmad, Richa Pant, Randeep Guleria, Balaram Ghosh, Anurag Agrawal BackgroundObesity is known to increase asthma risk and severity. Increased levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhi... περισσότερα »
Post-vaccination myositis and myocarditis in a previously healthy male
Post-vaccination myositis and myocarditis in a previously healthy male Matthew P. ChengEmail author, Michael G. Kozoriz, Amir A. Ahmadi, John Kelsall, Katryn Paquette and Jake M. Onrot Allergy, Asthma & Clinical Immunology201612:6 DOI: 10.1186/s13223-016-0114-4© Cheng et al. 2016 Received: 25 September 2015Accepted: 17 January 2016Published: 11 February 2016 Abstract Background The immunological literature has been redefining clinical phenomena as hypotheses emerge regarding causal links between triggers, immunologic manifestations, and their specific inflammatory cascade...περισσότερα »
The free serratus anterior artery perforator flap
The free serratus anterior artery perforator flap—A case report and anatomic study: We report a reconstructive case using a free serratus anterior artery perforator flap and an anatomic study. A 50-year-old man with upper esophageal sphincter stricture underwent segmental cervical esophageal resection. The size of the defect was approximately 5.5 cm. We then performed esophageal reconstruction using the free serratus anterior artery perforator flap. Esophagography performed on postoperative day 7 revealed no definite leakage and a viable anastomosis site with wide patency. No comp... περισσότερα »
Evaluation of Nasal Tip Definition in Closed Rhinoplasty
*Evaluation of Nasal Tip Definition in Closed Rhinoplasty: * *[image: image]* Author Information *From the Department of Plastic, Reconstructive and Aesthetic Surgery, Cork University Hospital, Wilton, Cork, Ireland.* *Presented at the Irish Association of Plastic Surgeons Meeting, May 14-15 2015, Galway, Ireland.* *Disclosure: The authors have no financial interest to declare in relation to the content of this article. The Article Processing Charge was paid for by The Irish Association of Plastic Surgeons.* *IAPS: Irish Association of Plastic Surgeons (IAPS) Summer Meeting, in Gal...περισσότερα »
Epidemiologic Research on Malformations Associated with Cleft Lip and Cleft Palate in Japan
Epidemiologic Research on Malformations Associated with Cleft Lip and Cleft Palate in Japan: by Hiroshi Koga, Koichi Iida, Tomoki Maeda, Mizuho Takahashi, Naoki Fukushima, Terufumi Goshi To investigate malformations associated with cleft lip and cleft palate, we conducted surveys at neonatal intensive care units (NICUs) and other non-NICU facilities and to determine whether there are differences among facilities. The regional survey investigated NICU facilities located in Oita Prefecture, including 92 patients with cleft lip and palate (CLP) or cleft palate (CP) that occurred betw... περισσότερα »
Minimally-invasive surgery in the management of symptomatic parotid stones
Minimally-invasive surgery in the management of symptomatic parotid stones: Traditionally, large, symptomatic, parotid stones that were refractory to conservative treatment were usually managed by parotidectomy, with the attendant risk to the facial nerve. Microendoscopes have transformed the management of such stones. For large stones that are not amenable to retrieval with a basket the endoscope provides a new dimension to operative surgery. It can guide the surgeon on to the duct and stone without the need to remove the parotid gland. In 2005-2014, 111 consecutive patients underw... περισσότερα »
The Correction of Asymmetric Deformity of Maxillofacial Fibrous Dysplasia.
Application of Reverse Engineering Template for the Correction of Asymmetric Deformity of Maxillofacial Fibrous Dysplasia.: Facial asymmetry deformity is the most common symptom of patients with fibrous dysplasia. This study provides a novel method based on computed tomography scan data, mirror-imaged reverse engineering and rapid prototyping for design and manufacture of an individual template guiding accurately the extent and quantity of partial resection of hyperplastic tissues to reshape the affected bones during operation. Ten adult patients with unilateral facial fibrous dyspl... περισσότερα »
Reconstruction of Extended Orbitomaxillectomy and Hemimandibulectomy Defects With Fibula Flaps and Patient-Specific Implants.
Reconstruction of Extended Orbitomaxillectomy and Hemimandibulectomy Defects With Fibula Flaps and Patient-Specific Implants.: An extended orbitomaxillectomy and hemimandibulectomy for polyostotic juvenile ossifying fibroma resection were performed with the assistance of patient-specific cutting guides. The resulting defects were reconstructed in stages. First, a patient-specific mandibular reconstruction plate was fixed to the hemimandibulectomy defect in the same operation as the resection. After margins were proven to be free of tumor on histologic analysis, a free fibula flap co... περισσότερα »
The first-line treatment of restless legs syndrome/willis-ekbom disease, prevention and treatment of dopaminergic augmentation
Guidelines for the first-line treatment of restless legs syndrome/willis-ekbom disease, prevention and treatment of dopaminergic augmentation: [image: sleep3013-fig-0001.sml] • Prevention of augmentation may be started by considering using medications such as α2δ ligands for initial RLS/WED treatment.• Alternatively, if dopaminergic drugs are elected as initial treatment, then the daily dose should be kept as low as possible and not exceed that recommended for RLS/WED treatment.• Patients with low iron stores should be given appropriate iron supplementation.• Treatment of exist...περισσότερα »
Vocal tract characteristics in Parkinson's disease.
Vocal tract characteristics in Parkinson's disease.: Purpose of review: Voice tremor is strongly linked to the Parkinson's disease speech-voice symptom complex. Little is known about the underlying anatomic source(s) of voice tremor when it occurs. We review recent literature addressing this issue. Additionally we report findings from a study we conducted employing rating of vocal tract structures viewed using nasolaryngoscopy during vocal and nonspeech tasks. Recent findings: In Parkinson's disease, using laryngeal electromyography, tremor has not been identified in muscles in the ...περισσότερα »
Diet standardization and bolus rheology in the management of dysphagia.
A review of diet standardization and bolus rheology in the management of dysphagia.: Purpose of review: Texture modification is a widespread practice as a strategy for the management of dysphagia and can be very effective in individual cases. However, it is often performed in a qualitative, subjective manner and practices vary internationally according to multiple sets of national guidelines. This article aims to identify best practice by reviewing the theory and practice of texture modification, focussing on recent advances. Recent findings: Instrumental assessment of texture modif... περισσότερα »
Differential diagnosis and management of spasmodic dysphonia.
Review of differential diagnosis and management of spasmodic dysphonia.: Purpose of review: The recent literature on spasmodic dysphonia is reviewed with regard to pathogenesis, differential diagnosis, treatment options, audits, and current methods of management. Recent findings: Advances in technology have enabled clinicians to better understand the connection between brain and laryngeal function and dysfunction. Refinements in imaging and genetic investigation techniques have led to advances in the understanding of the underlying mechanism of this neurolaryngeal disorder. Developm... περισσότερα »
Reconstructive techniques in skull base surgery after resection of malignant lesions: a wide array of choices.
Reconstructive techniques in skull base surgery after resection of malignant lesions: a wide array of choices.: Purpose of review: In this manuscript, we will provide a panorama of the current status of skull base reconstruction following endoscopic endonasal or open resection of malignant lesions, focusing on novel options and recent modifications of previously described techniques. Recent findings: New developments in skull base reconstruction continue to arise, mostly as in the form of vascularized pedicled flaps that can be used following endoscopic and open resections of the sk... περισσότερα »
DSPP Is Essential for Normal Development of the Dental-Craniofacial Complex
DSPP Is Essential for Normal Development of the Dental-Craniofacial Complex: The craniofacial skeleton is derived from both neural crest cells and mesodermal cells; however, the majority of the bone, cartilage, and connective tissue is derived from the neural crest. Dentin sialophosphoprotein (DSPP) is a precursor protein that is expressed by the connective tissues of the craniofacial skeleton, namely, bone and dentin with high expression levels in the dentin matrix. Gene ablation studies have shown severe dental defects in *DSPP*-null mutant mice. Therefore, to elucidate the role... περισσότερα »
RhoA-JNK Regulates the E-Cadherin Junctions of Human Gingival Epithelial Cells
RhoA-JNK Regulates the E-Cadherin Junctions of Human Gingival Epithelial Cells: The junctional epithelium (JE) is unique with regard to its wide intercellular spaces and sparsely developed intercellular junctions. Thus, knowledge of the molecular mechanisms that regulate the formation of the intercellular junctions of the junctional epithelium may be essential to understand the pathophysiology of the JE. HOK-16B cells, a normal human gingival epithelial cell line, were used to identify the molecules involved in the regulation of the formation of intercellular E-cadherin junctions ... περισσότερα »
Topography Influences Adherent Cell Regulation of Osteoclastogenesis
Topography Influences Adherent Cell Regulation of Osteoclastogenesis: The importance of osteoclast-mediated bone resorption in the process of osseointegration has not been widely considered. In this study, cell culture was used to investigate the hypothesis that the function of implant-adherent bone marrow stromal cells (BMSCs) in osteoclastogenesis is influenced by surface topography. BMSCs isolated from femur and tibia of Sprague-Dawley rats were seeded onto 3 types of titanium surfaces (smooth, micro, and nano) and a control surface (tissue culture plastic) with or without osteo...περισσότερα »
Apoptosis in Early Salivary Gland Duct Morphogenesis and Lumen Formation
Apoptosis in Early Salivary Gland Duct Morphogenesis and Lumen Formation: Salivary glands are essential for the maintenance of oral health by providing lubrication and antimicrobial protection to the mucosal and tooth surfaces. Saliva is modified and delivered to the oral cavity by a complex multifunctional ductal system. During development, these ducts form as solid tubes, which undergo cavitation to create lumens. Apoptosis has been suggested to play a role in this cavitation process along with changes in cell polarity. Here, we show that apoptosis occurs from the very earliest s... περισσότερα »
Alginate (Gaviscon Advance) vs. placebo as add-on therapy in reflux patients with inadequate response to a once daily proton pump inhibitor
Randomised clinical trial: alginate (Gaviscon Advance) vs. placebo as add-on therapy in reflux patients with inadequate response to a once daily proton pump inhibitor: Summary Background Many reflux patients remain symptomatic on a standard dose of proton pump inhibitor (PPI). Alginates decrease the number of reflux events by forming a raft on top of the stomach content and thus offer a supplemental mechanism of action to acid suppression. Aim To assess the efficacy of an alginate (Gaviscon Advance, Reckitt Benckiser, Slough, UK) on reflux symptoms in patients with persistent sympto...περισσότερα »
Attention Deficits and Language Impairments
Markers, Models, and Measurement Error: Exploring the Links Between Attention Deficits and Language Impairments: Purpose The empirical record regarding the expected co-occurrence of attention-deficit/hyperactivity disorder (ADHD) and specific language impairment is confusing and contradictory. A research plan is presented that has the potential to untangle links between these 2 common neurodevelopmental disorders. Method Data from completed and ongoing research projects examining the relative value of different clinical markers for separating cases of specific language impairment... περισσότερα »
Prosody and Semantics Are Separate but Not Separable Channels in the Perception of Emotional Speech: Test for Rating of Emotions in Speech
Prosody and Semantics Are Separate but Not Separable Channels in the Perception of Emotional Speech: Test for Rating of Emotions in Speech: Purpose Our aim is to explore the complex interplay of prosody (tone of speech) and semantics (verbal content) in the perception of discrete emotions in speech. Method We implement a novel tool, the Test for Rating of Emotions in Speech. Eighty native English speakers were presented with spoken sentences made of different combinations of 5 discrete emotions (anger, fear, happiness, sadness, and neutral) presented in prosody and semantics. List...περισσότερα »
White Noise For Tinnitus
White Noise For Tinnitus: ------------------------------ If you are someone who has suffered with tinnitus, you know all too well how irritating it can be. Most people describe tinnitus as a ringing sound heard in the ears, but other sounds such as a roaring or rushing sound that is like what you may hear at the ocean, clicking, hissing, or even unclear voices can be heard. These sounds are heard when there are no external factors around to produce them. Tinnitus can be difficult to diagnose. Many people suffer for years before seeking help, and even then, diagnosis can be diffic... περισσότερα »
Supplementing Hearing Aid Use with Listening and Communication Enhancement (LACE) Auditory Training.
A Randomized Control Trial: Supplementing Hearing Aid Use with Listening and Communication Enhancement (LACE) Auditory Training.: Objective: To examine the effectiveness of the Listening and Communication Enhancement (LACE) program as a supplement to standard-of-care hearing aid intervention in a Veteran population. Design: A multisite randomized controlled trial was conducted to compare outcomes following standard-of-care hearing aid intervention supplemented with (1) LACE training using the 10-session DVD format, (2) LACE training using the 20-session computer-based format, (3) pl... περισσότερα »
The Effects of Acoustic Bandwidth on Simulated Bimodal Benefit in Children and Adults with Normal Hearing.
The Effects of Acoustic Bandwidth on Simulated Bimodal Benefit in Children and Adults with Normal Hearing.: Objectives: The primary purpose of this study was to examine the effect of acoustic bandwidth on bimodal benefit for speech recognition in normal-hearing children with a cochlear implant (CI) simulation in one ear and low-pass filtered stimuli in the contralateral ear. The effect of acoustic bandwidth on bimodal benefit in children was compared with the pattern of adults with normal hearing. Our hypothesis was that children would require a wider acoustic bandwidth than adults ... περισσότερα »
Construction of a multipurpose photochemical reactor with on-line spectrophotometric detection
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Photochem. Photobiol. Sci., 2016, Accepted Manuscript DOI: 10.1039/C5PP00407A, Technical Note Tamas Ditroi, Jozsef Kalmar, Jose Angel Pino-Chamorro, Zsolt Erdei, Gabor Lente, Istvan Fabian A versatile photoreactor was built for studying homogeneous and heterogeneous photochemical reactions using fiber-optic devices. The reactor was designed to allow simultaneous photochemical initiation and online spectrophotometric monitoring of the… The content […]
Nano – dangerously big. New findings on the pseudoallergy phenomenon CARPA
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1oZYtL6 via IFTTT
Liste d’attesa e ticket, il 10% degli italiani rinuncia a curarsi – Bussola Sanità
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Bussola Sanità Liste d’attesa e ticket, il 10% degli italiani rinuncia a curarsi Bussola Sanità Un italiano su dieci rinuncia a curarsi per motivi economici e liste d’attesa troppo lunghe. È questo uno dei dati più allarmanti del rapporto 2015 dell’Osservatorio civico sul federalismo in sanità, presentato da Cittadinanzattiva oggi, 23 febbraio, a … and […]
-Stability of Positive Linear Systems
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
The main purpose of this work is to show that the Perron-Frobenius eigenstructure of a positive linear system is involved not only in the characterization of long-term behavior (for which well-known results are available) but also in the characterization of short-term or transient behavior. We address the analysis of the short-term behavior by the help […]
Evaluating Spatiotemporal Variation of Groundwater Depth/Level in Beijing Plain, a Groundwater-Fed Area from 2001 to 2010
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Groundwater has always been a valuable resource in Beijing, facing a great decline of groundwater level during the past decades. However, few previous researches have revealed the spatial variation of groundwater level within Beijing Plain. In this study, spatiotemporal variation of groundwater level from 2001 to 2010 in Beijing Plain has been investigated. Factor analysis […]
The complete genome sequences of two naturally occurring recombinant isolates of Sugarcane mosaic virus from Iran
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Abstract Sugarcane mosaic virus (SCMV) is the most prevalent virus causing sugarcane mosaic and maize dwarf mosaic diseases. Here, we presented the first two complete genomic sequences of Iranian SCMV isolates, NRA and ZRA from sugarcane and maize. The complete genome sequences of NRA and ZRA were, respectively, 9571 and 9572 nucleotides (nt) in length, […]
No link between macrolide antibiotics and ventricular arrhythmias, study finds
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Use of macrolide antibiotics in older adults is not associated with an increased risk of ventricular arrhythmias, a large retrospective cohort study has found.1The findings contradicted those of a… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21nsVNf via IFTTT
Counselling women with congenital cardiac disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Preconception counselling is particularly important for women with congenital heart disease because these conditions are the leading direct cause of maternal death in many developed countries,… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1oEHtdu via IFTTT
Cardiac abnormalities may help identify women at risk of recurrent pre-eclampsia
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Doctors may be able to identify which women are at high risk of recurrent pre-eclampsia by using echocardiography to look for certain cardiovascular abnormalities between pregnancies, say researchers… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21nsUc7 via IFTTT
Who explicitly requests the ordering of computed tomography for emergency department patients? A multicenter prospective study
Emergency Radiology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1TwyA0Q via IFTTT
Early lactate clearance for predicting active bleeding in critically ill patients with acute upper gastrointestinal bleeding: a retrospective study
Internal and Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1oySk8h via IFTTT
Heme oxygenase-1 induction in hepatocytes and non-parenchymal cells protects against liver injury during endotoxemia
Comparative Hepatology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1TwyA0G via IFTTT
Discriminative power of the HEART score for obstructive coronary artery disease in acute chest pain patients referred for CCTA
Critical Pathways in Cardiology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1oySk8d via IFTTT
Predicting pseudocyst formation following pancreatic trauma in pediatric patients
Pediatric Surgery International from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1TwyA0E via IFTTT
Systemic oral antibiotics as a prophylactic measure to prevent endophthalmitis in patients with open globe injuries in comparison with intravenous antibiotics
Retina from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1oySix6 via IFTTT
Chronic pancreatitis and fracture: a retrospective, population-based veterans administration study
Pancreas from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1TwyA0C via IFTTT
The clinical significance of small subarachnoid hemorrhages
Emergency Radiology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1oySjRR via IFTTT
Acute care surgery: Defining mortality in emergency general surgery in the state of Maryland
Journal of the American College of Surgeons from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Twyy9h via IFTTT
CT imaging signs of surgically proven bowel trauma
Emergency Radiology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1oySigK via IFTTT
Public injury prevention system in the Italian manufacturing sector: What types of inspection are more effective?
American Journal of Industrial Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1TwyzKg via IFTTT
Major mental disorders, gender, and criminological circumstances of homicide
Journal of Forensic and Legal Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1oySjRL via IFTTT
Interrater reliability of emergency physician-performed ultrasonography for diagnosing femoral, popliteal, and great saphenous vein thromboses compared to the criterion standard study by radiology
Journal of Clinical Ultrasound from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Twyy9b via IFTTT
Presenting characteristics of children who required neurosurgical intervention for head injury
Child's Nervous System from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1oySigC via IFTTT
Recurrent laryngeal nerve liberations and reconstructions: a single institution experience
World Journal of Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Twyy95 via IFTTT
Predicted effect of selectively testing female donors for HLA antibodies to mitigate transfusion-related acute lung injury risk from apheresis platelets
Transfusion from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1oySjRE via IFTTT
Community acquired acute kidney injury: A challenge and opportunity for primary care in kidney health
Nephrology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1TwyztO via IFTTT
Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Mutations in the TERT promoter, ALK rearrangement, and the BRAF V600E mutation are associated with aggressive clinicopathologic features in thyroid cancers. However, little is known about the impact of TERT promo... from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1T3O12a via IFTTT
Fusion of the HMGA2 and C9orf92 genes in myolipoma with t(9;12)(p22;q14)
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Myolipoma of soft tissue is an extremely rare benign tumor composed of mature adipose tissue and smooth muscle cells. It is found predominantly in women. The cytogenetic and molecular genetic features of myoli... from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1VBqKlH via IFTTT
Post-vaccination myositis and myocarditis in a previously healthy male
The immunological literature has been redefining clinical phenomena as hypotheses emerge regarding causal links between triggers, immunologic manifestations, and their specific inflammatory cascades. Of late, ... from Allergy\Immunology via ola Kala on Inoreader http://ift.tt/1Uk8GOA via IFTTT
Cutaneous Manifestations Associated with Melanoma
Publication date: Available online 23 February 2016 *Source:*Seminars in Oncology Author(s): Ritva Vyas, Jacqueline Selph, Meg R. Gerstenblith Melanoma is a malignancy most commonly arising from the skin; therefore, primary melanoma characteristics are usually the first cutaneous manifestations of melanoma. Cutaneous metastases, which can occur locally or diffusely, are important to detect in a timely manner as treatments for advanced melanoma that impact survival are now available. Melanoma can be associated with local or diffuse pigmentation changes, including depigmentation assoc...περισσότερα »
Cutaneous Manifestations Associated with Melanoma
Publication date: Available online 23 February 2016 *Source:*Seminars in Oncology Author(s): Ritva Vyas, Jacqueline Selph, Meg R. Gerstenblith Melanoma is a malignancy most commonly arising from the skin; therefore, primary melanoma characteristics are usually the first cutaneous manifestations of melanoma. Cutaneous metastases, which can occur locally or diffusely, are important to detect in a timely manner as treatments for advanced melanoma that impact survival are now available. Melanoma can be associated with local or diffuse pigmentation changes, including depigmentation assoc...περισσότερα »
Cutaneous Manifestations Associated with Melanoma
Publication date: Available online 23 February 2016 *Source:*Seminars in Oncology Author(s): Ritva Vyas, Jacqueline Selph, Meg R. Gerstenblith Melanoma is a malignancy most commonly arising from the skin; therefore, primary melanoma characteristics are usually the first cutaneous manifestations of melanoma. Cutaneous metastases, which can occur locally or diffusely, are important to detect in a timely manner as treatments for advanced melanoma that impact survival are now available. Melanoma can be associated with local or diffuse pigmentation changes, including depigmentation assoc...περισσότερα »
Incisionless transcranial MR-guided focused ultrasound in essential tremor: cerebellothalamic tractotomy
Already in the late 1960s and early 1970s, targeting of the "posterior subthalamic area (PSA)" was explored by different functional neurosurgical groups applying the radiofrequency (RF) technique to treat pati... from Pharmacology via ola Kala on Inoreader http://ift.tt/1XK5TxY via IFTTT
Risk Factors for Childhood Obesity in the First 1,000 Days
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
Publication date: Available online 22 February 2016 Source:American Journal of Preventive Medicine Author(s): Jennifer A. Woo Baidal, Lindsey M. Locks, Erika R. Cheng, Tiffany L. Blake-Lamb, Meghan E. Perkins, Elsie M. Taveras ContextMounting evidence suggests that the origins of childhood obesity and related disparities can be found as early as the “first 1,000 days”—the period […]
Interventions for Childhood Obesity in the First 1,000 Days A Systematic Review
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
Publication date: Available online 22 February 2016 Source:American Journal of Preventive Medicine Author(s): Tiffany L. Blake-Lamb, Lindsey M. Locks, Meghan E. Perkins, Jennifer A. Woo Baidal, Erika R. Cheng, Elsie M. Taveras ContextThe “first 1,000 days”—conception through age 24 months—are critical for the development and prevention of childhood obesity. This study systematically reviews existing and […]
Interleaved multivoxel 31P MR spectroscopy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
Purpose Separate measurements are required when investigating multiple exercising muscles with singlevoxel-localized dynamic 31P-MRS. With multivoxel spectroscopy, 31P-MRS time-series spectra are acquired from multiple independent regions during one exercise-recovery experiment with the same time resolution as for singlevoxel measurements. Methods Multiple independently selected volumes were localized using temporally interleaved semi-LASER excitations at 7T. Signal loss […]
Promotion of adipogenesis by 15-(S)-Hydroxyeicosatetraenoic acid
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
Publication date: Available online 22 February 2016 Source:Prostaglandins & Other Lipid Mediators Author(s): Yong-Seok Song, Dong Hun Lee, Jae-Hyuk Yu, Deok-Kun Oh, Jin Tae Hong, Do-Young Yoon Excess adipogenesis is a characteristic of obesity, which is associated with serious health problem, including type 2 diabetes. Here, to better understand the mechanisms for the development of […]
Drugs, Vol. 76, Issue 3 - New Issue Alert
If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 02/23/2016 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *Drugs*. Volume 76 Number 3 is now available online. Important news New: Drug Discovery and Evaluation: Pharmacological Assays Edited by: Franz J. Hock. Start reading on link.springer.com or recommend to your librarian. » Learn more In this issue Current Opinion Targeted Therapy for Idiopathic Pulmonary Fibrosis: Where To Now? Sunad Rangarajan, Morgan... περισσότερα »
Angela Joan Liebling-Carmalt
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
bmj;352/feb22_11/i1032/FIG1F1fig1Angela Joan Liebling-Carmalt was house officer at the Corbett Hospital in Stourbridge. She spent 12 years as principal in general practice in Erdington, Birmingham,… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1oEHsWW via IFTTT
Genetically modified mosquitos may be used in fight against Zika
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The World Health Organization is considering introducing transgenic mosquitos as a way of tackling the Zika virus.WHO’s vector control advisory group is to be convened in the next few weeks to look… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21nsTVt via IFTTT
David Ivor Whittingham
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
After graduating David Ivor Whittingham undertook house officer posts in Shrewsbury. He returned to Edinburgh in 1964, firstly to the Simpson Memorial Maternity Hospital as a senior house officer in… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1oEHsGB via IFTTT
saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription Cell Research advance online publication, February 23 2016. doi:10.1038/cr.2016.22 Authors: Victoria Portnoy, Szu Hua Sharon Lin, Kathy H Li, Alma Burlingame, Zheng-Hui Hu, Hao Li & Long-Cheng Li from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21nsUJ8 via IFTTT
tRNA fragments: novel players in intergenerational inheritance
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
tRNA fragments: novel players in intergenerational inheritance Cell Research advance online publication, February 23 2016. doi:10.1038/cr.2016.24 Authors: Katharina Gapp & Eric A Miska from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1oEHsq6 via IFTTT
An Ebola virus-encoded microRNA-like fragment serves as a biomarker for early diagnosis of Ebola virus disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
An Ebola virus-encoded microRNA-like fragment serves as a biomarker for early diagnosis of Ebola virus disease Cell Research advance online publication, February 23 2016. doi:10.1038/cr.2016.21 Authors: Zeliang Chen, Hongwei Liang, Xi Chen, Yuehua Ke, Zhen Zhou, Mingjuan Yang, Ke Zen, Ruifu Yang, Chao Liu & Chen-Yu Zhang from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21nsUsu […]
Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas Cell Research advance online publication, February 23 2016. doi:10.1038/cr.2016.23 Authors: Yu Hou, Huahu Guo, Chen Cao, Xianlong Li, Boqiang Hu, Ping Zhu, Xinglong Wu, Lu Wen, Fuchou Tang, Yanyi Huang & Jirun Peng from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1oEHu17 via […]
Keeping homologous recombination in check
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Keeping homologous recombination in check Cell Research advance online publication, February 23 2016. doi:10.1038/cr.2016.25 Authors: Kasper Fugger & Stephen C West from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21nsSRm via IFTTT
Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse Cell Research advance online publication, February 23 2016. doi:10.1038/cr.2016.20 Authors: Chao Yu, Shu-Yan Ji, Yu-Jiao Dang, Qian-Qian Sha, Yi-Feng Yuan, Jian-Jie Zhou, Li-Ying Yan, Jie Qiao, Fuchou Tang & Heng-Yu Fan from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1KGGuDq via IFTTT
Comparison of the correlations between impact loading rates and peak accelerations measured at two different body sites: intra- and inter-subject analysis
Publication date: Available online 23 February 2016 *Source:*Gait & Posture Author(s): Janet H. Zhang, Winko W. An, Ivan P.H. Au, Tony L. Chen, Roy T.H. Cheung BackgroundHigh average (VALR) and instantaneous vertical loading rates (VILR) during impact have been associated with many running-related injuries. Peak acceleration (PA), measured with an accelerometer, has provided an alternative method to estimate impact loading during outdoor running. This study sought to compare both intra- and inter-subject correlations between vertical loading rates and PA measured at two body sites ...περισσότερα »
Treadmill Walking is not Equivalent to Overground Walking for the Study of Walking Smoothness and Rhythmicity in Older Adults
Publication date: Available online 22 February 2016 *Source:*Gait & Posture Author(s): Brandi S. Row Lazzarini, Theodore J. Kataras Treadmills are appealing for gait studies, but some gait mechanics are disrupted during treadmill walking. The purpose of this study was to examine the effects of speed and treadmill walking on walking smoothness and rhythmicity of 40 men and women between the ages of 70-96 years. Gait smoothness was examined during overground (OG) and treadmill (TM) walking by calculating the harmonic ratio from linear accelerations measured at the level of the lumbar ... περισσότερα »
Reconstructive techniques in skull base surgery after resection of malignant lesions: a wide array of choices.
Purpose of review: In this manuscript, we will provide a panorama of the current status of skull base reconstruction following endoscopic endonasal or open resection of malignant lesions, focusing on novel options and recent modifications of previously described techniques. Recent findings: New developments in skull base reconstruction continue to arise, mostly as in the form of vascularized pedicled flaps that can be used following endoscopic and open resections of the skull base. Summary: Resection of skull base tumors, often creating large dural defects that couple with extensive... περισσότερα »
Review of differential diagnosis and management of spasmodic dysphonia.
Purpose of review: The recent literature on spasmodic dysphonia is reviewed with regard to pathogenesis, differential diagnosis, treatment options, audits, and current methods of management. Recent findings: Advances in technology have enabled clinicians to better understand the connection between brain and laryngeal function and dysfunction. Refinements in imaging and genetic investigation techniques have led to advances in the understanding of the underlying mechanism of this neurolaryngeal disorder. Development of diagnostic assessment tools and measures of quality of life hold t... περισσότερα »
A review of diet standardization and bolus rheology in the management of dysphagia.
Purpose of review: Texture modification is a widespread practice as a strategy for the management of dysphagia and can be very effective in individual cases. However, it is often performed in a qualitative, subjective manner and practices vary internationally according to multiple sets of national guidelines. This article aims to identify best practice by reviewing the theory and practice of texture modification, focussing on recent advances. Recent findings: Instrumental assessment of texture modification in vivo is challenging, and studies including rheology and perception have in... περισσότερα »
Vocal tract characteristics in Parkinson's disease.
Purpose of review: Voice tremor is strongly linked to the Parkinson's disease speech-voice symptom complex. Little is known about the underlying anatomic source(s) of voice tremor when it occurs. We review recent literature addressing this issue. Additionally we report findings from a study we conducted employing rating of vocal tract structures viewed using nasolaryngoscopy during vocal and nonspeech tasks. Recent findings: In Parkinson's disease, using laryngeal electromyography, tremor has not been identified in muscles in the vocal folds even when perceived auditorily. Prelimina...περισσότερα »
AGE-induced Keratinocyte MMP-9 Expression is Linked to TET2-mediated CpG Demethylation
Abstract Studies have documented that unusually high expression of matrix metalloproteinase-9 (MMP-9) suppresses wound healing during the late stages of diabetic foot ulcers. Recently, we reported that the presence of advanced glycation end products-bovine serum albumin (AGE-BSA) results in a higher expression of MMP-9 in skin primary keratinocytes. The aim of the present study was to elucidate the molecular machinery that is responsible for the inappropriately high AGEBSA-induced expression of MMP-9. We demonstrate that site-specific DNA demethylation plays an important role in M...περισσότερα »
Effects of Plant Growth Regulators on in-vitro regeneration of a potential medicinal plant -Scilla hyacinthina (Roth.) J.F. Macbr
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
2016-02-23T03-37-59Z *Source:* Journal of Applied Biology & Biotechnology K. Kamaleswari, V. Nandagopalan, A. Lakshmi Prabha. A suitable plant regeneration protocol has been developed from scale leaf and bulb scale explants of Scillahyacinthine, a medicinally important plant species belonging to the family liliaceae.The maximum number of shoots (13.2), with average length 6.5 cm, was achieved with medium containing 1.5 mg/l TDZ. Rooting of shoots was achieved on half-strength MS medium supplemented with 1.5 mg/1 IAA. from Scope via xlomafota13 on Inoreader http://ift.tt/1QXLXCv via... περισσότερα »
Properties of phenoloxidase from haemocytes of Scylla tranquebarica
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
2016-02-23T03-37-59Z *Source:* Journal of Applied Biology & Biotechnology A. S. Sabu, K. P. Jithendran, C. Gopal. The presence of phenoloxidase (PO) activity in the haemocytes of Scylla tranquebarica was electrophoretically and spectrophotometrically studied. Majority of the enzyme was located as proenzyme, prophenoloxidase (proPO) in the haemocytes. The enzyme prefers L-dihydroxyphenylalanine (L-dopa) as its substrate than phenol and is optimally active at pH 8.0. Besides trypsin, the proPO was also activated by both Gram positive and Gram negative microbes in vitro while, chemical... περισσότερα »
Genotype x environment interaction and kernel yield-stability of groundnut (Arachis hypogaea L.) in Northern Cameroon
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
2016-02-23T03-37-59Z *Source:* Journal of Applied Biology & Biotechnology Souina Dolinassou, Jean Baptiste Noubissie Tchiagam, Alain Djiranta Kemoral and Nicolas Njintang Yanou. ABSTRACT Kernel yield of thirteen groundnut varieties was studied for Genotype by Environment Interaction (GEI) in randomized complete block design with three replications across three locations of northern Cameroon using stability parameters and, Additive Main effects and Multiplicative Interaction analysis (AMMI). The objectives were to estimate the nature and magnitude of GEI, and to identify stable high-... περισσότερα »
Calibration of an instrumented treadmill using a precision-controlled device with artificial neural network-based error corrections
Publication date: March 2016 Source:Gait & Posture, Volume 45 Author(s): Hong-Jung Hsieh, Hsiu-Chen Lin, Hsuan-Lun Lu, Ting-Yi Chen, Tung-Wu Lu Instrumented treadmills (ITs) are used to measure reaction forces (RF) and center of pressure (COP) movements for gait and balance assessment. Regular in situ calibration is essential to ensure their accuracy and to identify conditions… Continue reading Calibration of an instrumented treadmill using a precision-controlled device with artificial neural network-based error corrections
Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis
Tumor necrosis factor (TNF) has pleiotropic functions during both the demyelinating autoimmune disease multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). How TNF regu… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RYz4wK via IFTTT
Comparison of the correlations between impact loading rates and peak accelerations measured at two different body sites: intra- and inter-subject analysis
Publication date: Available online 23 February 2016 Source:Gait & Posture Author(s): Janet H. Zhang, Winko W. An, Ivan P.H. Au, Tony L. Chen, Roy T.H. Cheung BackgroundHigh average (VALR) and instantaneous vertical loading rates (VILR) during impact have been associated with many running-related injuries. Peak acceleration (PA), measured with an accelerometer, has provided an alternative… Continue reading Comparison of the correlations between impact loading rates and peak accelerations measured at two different body sites: intra- and inter-subject analysis
The expression of the chemokine receptor CCR5 in tick-borne encephalitis
Chemokine receptor 5 (CCR5) is hypothesized to drive the lymphocyte migration to central nervous system in flavivirus encephalitis, and the non-functional CCR5Δ32 genetic variant was identified as a risk factor o… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mUGLHs via IFTTT
Corrigendum to “The relationships between foot-joints range of motion and plantar pressure in the normal foot” Gait Posture 42 (September (Suppl. 2)) (2015) S24
Publication date: Available online 23 February 2016 Source:Gait & Posture Author(s): Paolo Caravaggi, Alberto Leardini, Claudia Giacomozzi from #Audiology via ola Kala on Inoreader http://ift.tt/1RYxUBl via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/20SzsgC via IFTTT
Bilateral neuroinflammatory processes in visual pathways induced by unilateral ocular hypertension in the rat
Glaucoma is one of the leading causes of irreversible blindness in the world. The major risk factor is elevated intraocular pressure (IOP) leading to progressive retinal ganglion cell (RGC) death from the opti… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RYz2ox via IFTTT
Comparison of the correlations between impact loading rates and peak accelerations measured at two different body sites: intra- and inter-subject analysis
Publication date: Available online 23 February 2016 Source:Gait & Posture Author(s): Janet H. Zhang, Winko W. An, Ivan P.H. Au, Tony L. Chen, Roy T.H. Cheung BackgroundHigh average (VALR) and instantaneous vertical loading rates (VILR) during impact have been associated with many running-related injuries. Peak acceleration (PA), measured with an accelerometer, has provided an alternative… Continue reading Comparison of the correlations between impact loading rates and peak accelerations measured at two different body sites: intra- and inter-subject analysis
CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model
Interaction of CD200 with its receptor CD200R has an immunoregulatory role and attenuates various types of neuroinflammatory diseases. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mUGKmB via IFTTT
Treadmill Walking is not Equivalent to Overground Walking for the Study of Walking Smoothness and Rhythmicity in Older Adults
Publication date: Available online 22 February 2016 Source:Gait & Posture Author(s): Brandi S. Row Lazzarini, Theodore J. Kataras Treadmills are appealing for gait studies, but some gait mechanics are disrupted during treadmill walking. The purpose of this study was to examine the effects of speed and treadmill walking on walking smoothness and rhythmicity of 40… Continue reading Treadmill Walking is not Equivalent to Overground Walking for the Study of Walking Smoothness and Rhythmicity in Older Adults
Protection from experimental autoimmune encephalomyelitis by polyclonal IgG requires adjuvant-induced inflammation
Intravenous immunoglobulin (IVIG) proved to be an efficient anti-inflammatory treatment for a growing number of neuroinflammatory diseases and protects against the development of experimental autoimmune enceph… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RYz286 via IFTTT
Corrigendum to “The relationships between foot-joints range of motion and plantar pressure in the normal foot” [Gait Posture 42 (September (Suppl. 2)) (2015) S24]
Publication date: Available online 23 February 2016 *Source:*Gait & Posture Author(s): Paolo Caravaggi, Alberto Leardini, Claudia Giacomozzi from #Audiology via ola Kala on Inoreader http://ift.tt/1RYxUBl via IFTTT
Building functional networks of spiking model neurons
Nature Neuroscience 19, 350 (2016). doi:10.1038/nn.4241 Authors: L F Abbott, Brian DePasquale & Raoul-Martin Memmesheimer from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Os4EMA via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QzIRdC via IFTTT
Schizophrenia and brain volume genetic covariation
Nature Neuroscience 19, 419 (2016). doi:10.1038/nn0316-419 Author: P Alexander Arguello from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Qe0qOq via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Q8ePYP via IFTTT
Nonsteroidal anti-inflammatory–induced inhibition of signal transducer and activator of transcription 6 (STAT-6) phosphorylation in aspirin-exacerbated respiratory disease
Publication date: Available online 23 February 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Rohit K. Katial, Michael Martucci, Trever Burnett, Anna Faino, Lindsay Finkas, Sucai Liu, Rafeul Alam BackgroundAspirin desensitization provides long-term clinical benefits. The exact mechanisms of aspirin desensitization are not clearly understood.ObjectiveWe sought to evaluate the effects of nonsteroidal anti-inflammatory drugs (NSAIDs)… Continue reading Nonsteroidal anti-inflammatory–induced inhibition of signal transducer and activator of transcription 6 (STAT-6) phos... περισσότερα »
Randomized phase 1 study of the phosphatidylinositol 3-kinase δ inhibitor idelalisib in patients with allergic rhinitis
Publication date: Available online 23 February 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Friedrich Horak, Kamal D. Puri, Bart H. Steiner, Leanne Holes, Guan Xing, Petra Zieglmayer, René Zieglmayer, Patrick Lemell, Albert Yu BackgroundPhosphatidylinositol 3-kinase p110δ isoform (PI3K p110δ) activity is essential for mast cell activation, suggesting that inhibition of PI3K p110δ might be… Continue reading Randomized phase 1 study of the phosphatidylinositol 3-kinase δ inhibitor idelalisib in patients with allergic rhinitis
Using goal-driven deep learning models to understand sensory cortex
Nature Neuroscience 19, 356 (2016). doi:10.1038/nn.4244 Authors: Daniel L K Yamins & James J DiCarlo from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Os4GnF via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QzIPT2 via IFTTT
Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-to-severe asthma
Publication date: Available online 23 February 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Eric D. Bateman, Udo-Michael Goehring, Frank Richard, Henrik Watz BackgroundRoflumilast, a selective phosphodiesterase 4 inhibitor, has been shown to provide modest improvements in lung function in patients with mild-to-moderate asthma, but its efficacy in patients with moderate-to-severe asthma has not been… Continue reading Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-to-severe asthma
Computational principles of memory
Nature Neuroscience 19, 394 (2016). doi:10.1038/nn.4237 Authors: Rishidev Chaudhuri & Ila Fiete from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Qe0spi via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QzIQX6 via IFTTT
The mechanics of state-dependent neural correlations
Nature Neuroscience 19, 383 (2016). doi:10.1038/nn.4242 Authors: Brent Doiron, Ashok Litwin-Kumar, Robert Rosenbaum, Gabriel K Ocker & Krešimir Josić from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Os4FAe via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Uk1v95 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Q8ePIp via… Continue reading The mechanics of state-dependent neural correlations
Confidence and certainty: distinct probabilistic quantities for different goals
Nature Neuroscience 19, 366 (2016). doi:10.1038/nn.4240 Authors: Alexandre Pouget, Jan Drugowitsch & Adam Kepecs from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Os4DbE via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QzIQX1 via IFTTT
Mismatch repair status in patients with primary operable colorectal cancer: associations with the local and systemic tumour environment
British Journal of Cancer from #Medicine via ola Kala on Inoreader http://ift.tt/1mUyS4M via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1L8gYqI via IFTTT
Early lactate clearance for predicting active bleeding in critically ill patients with acute upper gastrointestinal bleeding: a retrospective study
Internal and Emergency Medicine from #Medicine via ola Kala on Inoreader http://ift.tt/1TCshtU via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Q85T5M via IFTTT
Reconstruction of Extended Orbitomaxillectomy and Hemimandibulectomy Defects With Fibula Flaps and Patient-Specific Implants.
An extended orbitomaxillectomy and hemimandibulectomy for polyostotic juvenile ossifying fibroma resection were performed with the assistance of patient-specific cutting guides. The resulting defects were reconstructed in stages. First, a patient-specific mandibular reconstruction plate was fixed to the hemimandibulectomy defect in the same operation as the resection. After margins were proven to be free of tumor on histologic analysis, a free fibula flap contoured to the reconstruction plate was used to reconstruct the mandible. Reconstruction of the maxilla, alveolus, and orbit we...περισσότερα »
Application of Reverse Engineering Template for the Correction of Asymmetric Deformity of Maxillofacial Fibrous Dysplasia.
Facial asymmetry deformity is the most common symptom of patients with fibrous dysplasia. This study provides a novel method based on computed tomography scan data, mirror-imaged reverse engineering and rapid prototyping for design and manufacture of an individual template guiding accurately the extent and quantity of partial resection of hyperplastic tissues to reshape the affected bones during operation. Ten adult patients with unilateral facial fibrous dysplasia accepted these treatments, the postoperative appearances showed that the protrusions were effectively reduced; bilatera... περισσότερα »
Getting Physical: The Hypothesis Driven Physical Exam
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1XJSMg4 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TCjqbs via IFTTT
Health Care Use During Transfer to Adult Care Among Youth With Chronic Conditions
OBJECTIVE: To compare health care use and costs for youth with chronic health conditions before and after transfer from pediatric to adult health care services. METHODS: Youth born in Ontario, Canada, between April 1, 1989, and April 1, 1993, were assigned to 11 mutually exclusive, hierarchically arranged clinical groupings, including “complex” chronic conditions (CCCs), non-complex chronic conditions (N-CCCs), and chronic mental health conditions (CMHCs). Outcomes were compared between 2-year periods before and after transfer of pediatric services, the subjects’ 18th birthday. ... περισσότερα »
Autoimmunity Including Intestinal Behcet Disease Bearing the KRAS Mutation in Lymphocytes: A Case Report
We experienced the case of a 3-year-old male with a very rare combination of autoimmunity, including immune thrombocytopenia, recurrent Henoch-Schönlein purpura and intestinal Behcet disease. Exome sequencing of the patient’s peripheral blood mononuclear cells identified a *KRAS* G13C mutation. Interestingly, the *KRAS* G13C mutation was observed in T and B lymphocytes, as well as natural killer cells, but not granulocytes. Our case was completely phenotypically different from RASopathies and did not meet the criteria for Ras-associated lymphoproliferative disease or juvenile mye... περισσότερα »
Determinants of Health and Pediatric Primary Care Practices
More than 20% of children nationally live in poverty. Pediatric primary care practices are critical points-of-contact for these patients and their families. Practices must consider risks that are rooted in poverty as they determine how to best deliver family-centered care and move toward action on the social determinants of health. The Practice-Level Care Delivery Subgroup of the Academic Pediatric Association’s Task Force on Poverty has developed a roadmap for pediatric providers and practices to use as they adopt clinical practice redesign strategies aimed at mitigating poverty’s... περισσότερα »
Diagnostic reagent products stock(AD)
Dear Sir/Madam， How are you? I am Lisa, our company provides various kinds of HCG Pregnancy Test kits. If your company needs the items, we will pleasure to show you detailed information of that. Yours faithfully，lisa E-Mail：lisa_lanmi@foxmail.com from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Rk4NGz via IFTTT
The Effects of Acoustic Bandwidth on Simulated Bimodal Benefit in Children and Adults with Normal Hearing.
Objectives: The primary purpose of this study was to examine the effect of acoustic bandwidth on bimodal benefit for speech recognition in normal-hearing children with a cochlear implant (CI) simulation in one ear and low-pass filtered stimuli in the contralateral ear. The effect of acoustic bandwidth on bimodal benefit in children was compared with the pattern of adults with normal hearing. Our hypothesis was that children would require a wider acoustic bandwidth than adults to (1) derive bimodal benefit, and (2) obtain asymptotic bimodal benefit. Design: Nineteen children (6 to 12... περισσότερα »
A Randomized Control Trial: Supplementing Hearing Aid Use with Listening and Communication Enhancement (LACE) Auditory Training.
Objective: To examine the effectiveness of the Listening and Communication Enhancement (LACE) program as a supplement to standard-of-care hearing aid intervention in a Veteran population. Design: A multisite randomized controlled trial was conducted to compare outcomes following standard-of-care hearing aid intervention supplemented with (1) LACE training using the 10-session DVD format, (2) LACE training using the 20-session computer-based format, (3) placebo auditory training (AT) consisting of actively listening to 10 hr of digitized books on a computer, and (4) educational couns...περισσότερα »
First Presentation of Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome in Pregnancy
Background: Reed’s syndrome, also known as hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome, is an autosomal dominant condition in which affected individuals may develop cutaneous leiomyomas, uterine fibroids, and renal cell carcinoma. Objective: This report describes a unique case of HLRCC because it presented in pregnancy with development of cutaneous pilar leiomyomas. Methods: Review of the literature for previous cases of Reed’s syndrome during pregnancy including PubMed and Medline search. Results: Genetic testing of this patient demonstrated a mutation in ...περισσότερα »
Demoralization in Cancer Patients and Related Factors in Taiwan.
Background: Demoralization frequently occurs in hospice, cancer, and critically ill patients. Severe demoralization can lead to suicidal ideation, making this issue of great import to healthcare providers. Objective: The aim of this study is to inform nursing professionals of the risk factors of demoralization in cancer patients via investigating its relationship with cancer patients’ demographic data and disease characteristics. Methods: This is a cross-sectional descriptive study using a structured questionnaire including assessments of demographic data and disease characteristi... περισσότερα »
Adverse reactions in mRCC patients documented in routine practice by German office-based oncologists and uro-oncologists
Background Signal transduction inhibitors (STIs) have considerably improved treatment of advanced/metastasized renal cell carcinoma (mRCC). Most safety data for these drugs are derived from clinical trials. The purpose of this study was to evaluate which adverse drug reactions are documented during first-line treatments in routine clinical practice. Patients and methods The ongoing prospective German mRCC clinical registry is recruiting patients in 110 oncology and urology outpatient centers. Data from the first 250 patients who had completed first-line treatment were analyzed r... περισσότερα »
32. Deutscher Krebskongress Krebsmedizin heute: präventiv, personalisiert, präzise und partizipativ, Berlin, 24.-27. Februar 2016: Abstracts
Oncol Res Treat 2016;39(suppl 1):1-191 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TCfPtY via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PUCY7a via IFTTT
Treatment Modification in Young Breast Cancer Patients
Oncol Res Treat from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QdKZpd via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TChj7B via IFTTT
Peter Gärdenfors: The Geometry of Meaning: Semantics Based on Conceptual Spaces
from Uncategorized via xlomafota13 on Inoreader http://ift.tt/1PUBl9J via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/20Sfu5E via IFTTT
Tibor Solymosi and John R. Shook (eds.): Neuroscience, Neurophilosophy, and Pragmatism: Brains at Work with the World
from Uncategorized via xlomafota13 on Inoreader http://ift.tt/1L86gR3 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SPvHtb via IFTTT
Painful thumb carpometacarpal joint osteoarthritis - results of a novel treatment approach
Publication date: Available online 23 February 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Ehrl Denis, Erne Holger C., Broer P. Niclas, Metz Christian, Falter Erwin BackgroundPain reduction as well as preservation and improvement in range of motion remain the main aims in the treatment of thumb carpometacarpal (CMC) osteoarthritis (OA). We performed a retrospective outcome analysis of patients with symptomatic stage II - III thumb CMC joint arthritis treated with denervation, joint lavage and capsular imbrication.Methods73 patients with stage II to ...περισσότερα »
Isolation and characterization of extremely halophilic CO-oxidizing Euryarchaeota from hypersaline cinders, sediments and soils, and description of a novel CO oxidizer, Haloferax namakaokahaiae Mke2.3T, sp. nov.
The phylogenetic affiliations of organisms responsible for aerobic CO oxidation in hypersaline soils and sediments were assessed using media containing 3.8 M NaCl. CO-oxidizing strains of the euryarchaeotes, *Haloarcula*, *Halorubrum*, *Haloterrigena*, and *Natronorubrum*, were isolated from the Bonneville Salt Flats (UT) and Atacama Desert salterns (Chile). A halophilic euryarchaeote, *Haloferax* strain Mke2.3T, was isolated from Hawai’i Island saline cinders. *Haloferax* strain Mke2.3T was most closely related to *Hfx. larsenii* JCM 13917T (97.0% 16S rRNA sequence identity). It ...περισσότερα »
Biogeography of bacteriophages at four hydrothermal vent sites in the Antarctic based on gp23 sequence diversity
In this study, which was carried out within the ChEsSO consortium project (Chemosynthetically driven ecosystems south of the Polar Front), we sampled two hydrothermal vent sites on the East Scotia Ridge, Scotia Sea, one in the Kemp Caldera, South Sandwich Arc, and one in the Bransfield Strait, north-west of the Antarctic Peninsula, which exhibit strong differences in their chemical characteristics. We compared a subset of their bacteriophage population by Sanger- and 454-sequencing of *g23*, which codes for the major capsid protein of T4likeviruses. We found that the sites differ ... περισσότερα »
Butanol formation from gaseous substrates
Mostly, butanol is formed as a product by saccharolytic anaerobes, employing the so-called ABE fermentation (for acetone-butanol-ethanol). However, this alcohol can also be produced from gaseous substrates such as syn(thesis) gas (major components are carbon monoxide and hydrogen) by autotrophic acetogens. In view of economic considerations, a biotechnological process based on cheap and abundant gases such as CO and CO 2 as a carbon source is preferable to more expensive sugar or starch fermentation. In addition, any conflict for use of substrates that can also serve as human nutri... περισσότερα »
Longer, intense rehabilitation boosts recovery after brain injury
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Animal studies suggest greater emphasis for better results and highlight key role of brain system in rebuilding structure and function. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Q8huSd via IFTTT
Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Tumor necrosis factor (TNF) has pleiotropic functions during both the demyelinating autoimmune disease multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). How TNF regu… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RYz4wK via IFTTT
The expression of the chemokine receptor CCR5 in tick-borne encephalitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Chemokine receptor 5 (CCR5) is hypothesized to drive the lymphocyte migration to central nervous system in flavivirus encephalitis, and the non-functional CCR5Δ32 genetic variant was identified as a risk factor o… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mUGLHs via IFTTT
Bilateral neuroinflammatory processes in visual pathways induced by unilateral ocular hypertension in the rat
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Glaucoma is one of the leading causes of irreversible blindness in the world. The major risk factor is elevated intraocular pressure (IOP) leading to progressive retinal ganglion cell (RGC) death from the opti… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RYz2ox via IFTTT
CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Interaction of CD200 with its receptor CD200R has an immunoregulatory role and attenuates various types of neuroinflammatory diseases. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mUGKmB via IFTTT
Protection from experimental autoimmune encephalomyelitis by polyclonal IgG requires adjuvant-induced inflammation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Intravenous immunoglobulin (IVIG) proved to be an efficient anti-inflammatory treatment for a growing number of neuroinflammatory diseases and protects against the development of experimental autoimmune enceph… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RYz286 via IFTTT
Direct and indirect effects of ionizing radiation on grazer–phytoplankton interactions
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: May 2016 Source:Journal of Environmental Radioactivity, Volumes 155–156 Author(s): Francisco J.A. Nascimento, Clare Bradshaw Risk assessment of exposure to radionuclides and radiation does not usually take into account the role of species interactions. We investigated how the transfer of carbon between a primary producer, Raphidocelis subcapitata, and a consumer, Daphnia magna, was affected […]
Radiation recall dermatitis induced by sorafenib
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Radiation recall dermatitis (RRD) is an acute inflammatory reaction confined to previously irradiated skin, mainly subsequent to the administration of certain chemotherapeutics. Here we present a rare case of RRD induced by the oral multikinase inhibitor sorafenib. Case report A 77-year-old male with hepatocellular carcinoma was irradiated at ten different sites for bone […]
Corrigendum to “The relationships between foot-joints range of motion and plantar pressure in the normal foot” [Gait Posture 42 (September (Suppl. 2)) (2015) S24]
Publication date: Available online 23 February 2016 *Source:*Gait & Posture Author(s): Paolo Caravaggi, Alberto Leardini, Claudia Giacomozzi from #Audiology via ola Kala on Inoreader http://ift.tt/1RYxUBl via IFTTT
Calibration of an instrumented treadmill using a precision-controlled device with artificial neural network-based error corrections
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Hong-Jung Hsieh, Hsiu-Chen Lin, Hsuan-Lun Lu, Ting-Yi Chen, Tung-Wu Lu Instrumented treadmills (ITs) are used to measure reaction forces (RF) and center of pressure (COP) movements for gait and balance assessment. Regular in situ calibration is essential to ensure their accuracy and to identify conditions when a factory re-calibration is needed. The current study aimed to develop and calibrate in situ an IT using a portable, precision-controlled calibration device with an artificial neural network (ANN)-based ...περισσότερα »
Comparison of the correlations between impact loading rates and peak accelerations measured at two different body sites: intra- and inter-subject analysis
Publication date: Available online 23 February 2016 *Source:*Gait & Posture Author(s): Janet H. Zhang, Winko W. An, Ivan P.H. Au, Tony L. Chen, Roy T.H. Cheung BackgroundHigh average (VALR) and instantaneous vertical loading rates (VILR) during impact have been associated with many running-related injuries. Peak acceleration (PA), measured with an accelerometer, has provided an alternative method to estimate impact loading during outdoor running. This study sought to compare both intra- and inter-subject correlations between vertical loading rates and PA measured at two body sites du...περισσότερα »
Treadmill Walking is not Equivalent to Overground Walking for the Study of Walking Smoothness and Rhythmicity in Older Adults
Publication date: Available online 22 February 2016 *Source:*Gait & Posture Author(s): Brandi S. Row Lazzarini, Theodore J. Kataras Treadmills are appealing for gait studies, but some gait mechanics are disrupted during treadmill walking. The purpose of this study was to examine the effects of speed and treadmill walking on walking smoothness and rhythmicity of 40 men and women between the ages of 70-96 years. Gait smoothness was examined during overground (OG) and treadmill (TM) walking by calculating the harmonic ratio from linear accelerations measured at the level of the lumbar sp... περισσότερα »
Corrigendum to “The relationships between foot-joints range of motion and plantar pressure in the normal foot” [Gait Posture 42 (September (Suppl. 2)) (2015) S24]
Publication date: Available online 23 February 2016 *Source:*Gait & Posture Author(s): Paolo Caravaggi, Alberto Leardini, Claudia Giacomozzi from #Audiology via ola Kala on Inoreader http://ift.tt/1RYxUBl via IFTTT
Calibration of an instrumented treadmill using a precision-controlled device with artificial neural network-based error corrections
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Hong-Jung Hsieh, Hsiu-Chen Lin, Hsuan-Lun Lu, Ting-Yi Chen, Tung-Wu Lu Instrumented treadmills (ITs) are used to measure reaction forces (RF) and center of pressure (COP) movements for gait and balance assessment. Regular in situ calibration is essential to ensure their accuracy and to identify conditions when a factory re-calibration is needed. The current study aimed to develop and calibrate in situ an IT using a portable, precision-controlled calibration device with an artificial neural network (ANN)-based ...περισσότερα »
Comparison of the correlations between impact loading rates and peak accelerations measured at two different body sites: intra- and inter-subject analysis
Publication date: Available online 23 February 2016 *Source:*Gait & Posture Author(s): Janet H. Zhang, Winko W. An, Ivan P.H. Au, Tony L. Chen, Roy T.H. Cheung BackgroundHigh average (VALR) and instantaneous vertical loading rates (VILR) during impact have been associated with many running-related injuries. Peak acceleration (PA), measured with an accelerometer, has provided an alternative method to estimate impact loading during outdoor running. This study sought to compare both intra- and inter-subject correlations between vertical loading rates and PA measured at two body sites du...περισσότερα »
Treadmill Walking is not Equivalent to Overground Walking for the Study of Walking Smoothness and Rhythmicity in Older Adults
Publication date: Available online 22 February 2016 *Source:*Gait & Posture Author(s): Brandi S. Row Lazzarini, Theodore J. Kataras Treadmills are appealing for gait studies, but some gait mechanics are disrupted during treadmill walking. The purpose of this study was to examine the effects of speed and treadmill walking on walking smoothness and rhythmicity of 40 men and women between the ages of 70-96 years. Gait smoothness was examined during overground (OG) and treadmill (TM) walking by calculating the harmonic ratio from linear accelerations measured at the level of the lumbar sp... περισσότερα »
Corrigendum to “The relationships between foot-joints range of motion and plantar pressure in the normal foot” [Gait Posture 42 (September (Suppl. 2)) (2015) S24]
Publication date: Available online 23 February 2016 *Source:*Gait & Posture Author(s): Paolo Caravaggi, Alberto Leardini, Claudia Giacomozzi from #Audiology via xlomafota13 on Inoreader http://ift.tt/1RYxUBl via IFTTT
Calibration of an instrumented treadmill using a precision-controlled device with artificial neural network-based error corrections
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Hong-Jung Hsieh, Hsiu-Chen Lin, Hsuan-Lun Lu, Ting-Yi Chen, Tung-Wu Lu Instrumented treadmills (ITs) are used to measure reaction forces (RF) and center of pressure (COP) movements for gait and balance assessment. Regular in situ calibration is essential to ensure their accuracy and to identify conditions when a factory re-calibration is needed. The current study aimed to develop and calibrate in situ an IT using a portable, precision-controlled calibration device with an artificial neural network (ANN)-based ...περισσότερα »
Comparison of the correlations between impact loading rates and peak accelerations measured at two different body sites: intra- and inter-subject analysis
Publication date: Available online 23 February 2016 *Source:*Gait & Posture Author(s): Janet H. Zhang, Winko W. An, Ivan P.H. Au, Tony L. Chen, Roy T.H. Cheung BackgroundHigh average (VALR) and instantaneous vertical loading rates (VILR) during impact have been associated with many running-related injuries. Peak acceleration (PA), measured with an accelerometer, has provided an alternative method to estimate impact loading during outdoor running. This study sought to compare both intra- and inter-subject correlations between vertical loading rates and PA measured at two body sites du...περισσότερα »
Treadmill Walking is not Equivalent to Overground Walking for the Study of Walking Smoothness and Rhythmicity in Older Adults
Publication date: Available online 22 February 2016 *Source:*Gait & Posture Author(s): Brandi S. Row Lazzarini, Theodore J. Kataras Treadmills are appealing for gait studies, but some gait mechanics are disrupted during treadmill walking. The purpose of this study was to examine the effects of speed and treadmill walking on walking smoothness and rhythmicity of 40 men and women between the ages of 70-96 years. Gait smoothness was examined during overground (OG) and treadmill (TM) walking by calculating the harmonic ratio from linear accelerations measured at the level of the lumbar sp... περισσότερα »
Predictive factors of depressive symptoms of elderly patients with cancer receiving first-line chemotherapy
Abstract Background Depression is the most common psychiatric disorder in geriatrics and oncology. For elderly cancer patients, it has a significant impact on quality of life, morbidity, and mortality. Nevertheless, depression is under-diagnosed and under-treated. Cancer management is key in improving the quality of care in this population. We aim to identify sociodemographic, clinical, and treatment-related factors of depression in elderly patients during chemotherapy, thus allowing early detection of patients in need of specific treatment. Further, we investigate whether chemot... περισσότερα »
Long-term outcomes of a phase II randomized controlled trial comparing intensity-modulated radiotherapy with or without weekly cisplatin for the treatment of locally recurrent nasopharyngeal carcinoma
Salvage treatment for locally recurrent nasopharyngeal carcinoma (NPC) is complicated and relatively limited. Radiotherapy, combined with effective concomitant chemotherapy, may improve clinical treatment out... from Cancer via ola Kala on Inoreader http://ift.tt/1Qe2CFA via IFTTT
Future options of anti-angiogenic cancer therapy
In human patients, drugs that block tumor vessel growth are widely used to treat a variety of cancer types. Many rigorous phase 3 clinical trials have demonstrated significant survival benefits; however, the a... from Cancer via ola Kala on Inoreader http://ift.tt/1Q8gihM via IFTTT
Why some tumours trigger neovascularisation and others don’t: the story thus far
Angiogenesis is not essential for tumours to develop and expand, as cancer can also grow in a non-angiogenic fashion, but why this type of growth occurs is unknown. Surprisingly, our data from mRNA transcripti... from Cancer via ola Kala on Inoreader http://ift.tt/1Qe2E04 via IFTTT
Mechanisms of vascularization in murine models of primary and metastatic tumor growth
Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; in... from Cancer via ola Kala on Inoreader http://ift.tt/1XK3Nya via IFTTT
Body mass index in relation to serum prostate-specific antigen levels and prostate cancer risk
Abstract High Body mass index (BMI) has been directly associated with risk of aggressive or fatal prostate cancer. One possible explanation may be an effect of BMI on serum levels of prostate-specific antigen (PSA). To study the association between BMI and serum PSA as well as prostate cancer risk, a large cohort of men without prostate cancer at baseline was followed prospectively for prostate cancer diagnoses until 2015. Serum PSA and BMI were assessed among 15,827 men at baseline in 2010-2012. During follow-up, 735 men were diagnosed with prostate cancer with 282 (38.4%) classif...περισσότερα »
Adjuvant chemotherapy is not associated with improved survival for all high risk factors in stage II colon cancer
Abstract Adjuvant chemotherapy can be considered in high-risk stage II colon cancer comprising pT4, poor/undifferentiated grade, vascular invasion, emergency surgery and/or <10 evaluated lymph nodes (LNs). Adjuvant chemotherapy administration and its effect on survival was evaluated for each known risk factor. All patients with high risk stage II colon cancer who underwent resection and were diagnosed in the Netherlands between 2008-2012 were included. After stratification by risk factor(s) (vascular invasion could not be included), Cox regression was used to discriminate the indep...περισσότερα »
Molecular basis and current strategies of therapeutic arginine depletion for cancer
Abstract Renewed interest in the use of therapeutic enzymes combined with an improved knowledge of cancer cell metabolism, has led to the translation of several arginine depletion strategies into early phase clinical trials. Arginine auxotrophic tumors are reliant on extracellular arginine, due to the downregulation of arginosuccinate synthetase (ASS-1) or ornithine transcarbamylase (OTC) - key enzymes for intracellular arginine recycling. Engineered arginine catabolic enzymes such as recombinant human arginase (rh-Arg1-PEG) and arginine deiminase (ADI-PEG) have demonstrated cytot...περισσότερα »
Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model
Abstract Neuroblastoma is the most common extra-cranial malignancy in childhood and accounts for approximately 15% of childhood cancer deaths. Amplification of MYCN in neuroblastoma is associated with aggressive disease and predicts for poor prognosis. Novel therapeutic approaches are therefore essential to improving patient outcomes in this setting. The histone deacetylases are known to interact with N-Myc and regulate numerous cellular processes via epigenetic modulation, including differentiation. In this study we utilised the TH-MYCN mouse model of neuroblastoma to investigate ...περισσότερα »
The novel mitochondria-targeted antioxidant SkQ1 modulates angiogenesis and inflammatory micromilieu in a murine orthotopic model of pancreatic cancer
Abstract Our understanding in the last few years about reactive oxygen species (ROS) has changed from being harmful substances to crucial intra- and extracellular messengers as well as important regulators controlling a wide spectrum of signaling pathways, including those in cancer immunology. Therefore, these multiple essential roles of ROS and especially of mitochondria-derived ROS in malignant transformation and cancer progression make them a promising target for anticancer therapy. Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers in the world. A link bet...περισσότερα »
Abrus agglutinin is a potent anti-proliferative and anti-angiogenic agent in human breast cancer
Abstract *Abrus* agglutinin (AGG), a plant lectin isolated from the seeds of *Abrus precatorius*, has documented antitumor and immunostimulation effects in murine models. To examine possible antitumor activity against breast cancer, we established human breast tumor xenografts in athymic nude mice and intraperitoneally administered AGG. AGG inhibited tumor growth and angiogenesis as confirmed by monitoring the expression of Ki-67 and CD-31, respectively. In addition, TUNEL positive cells increased in breast tumors treated with AGG suggesting that AGG mediates anti-tumorigenic activ...περισσότερα »
Age and gender related neuromuscular pattern during trunk flexion-extension in chronic low back pain patients
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
The root mean square surface electromyographic activity of lumbar extensor muscles during dynamic trunk flexion and extension from standing has repeatedly been recommended to objectively assess muscle function... from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1KGCwuD via IFTTT
Kinematic and kinetic assessment of upper limb movements in patients with writer's cramp
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
The assessment and treatment of writer's cramp is complicated due to the variations in the forces and angles of involved joints. Additionally, in some cases compensatory movements for cramp relief further comp... from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1WFWNRE via IFTTT
Journal of NeuroEngineering and Rehabilitation reviewer acknowledgement 2015
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
The editors of Journal of NeuroEngineering and Rehabilitation would like to thank all of our reviewers who have contributed to the journal in volume 12 (2015). from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1KGCyCN via IFTTT
Radiation recall dermatitis induced by sorafenib
Abstract Background Radiation recall dermatitis (RRD) is an acute inflammatory reaction confined to previously irradiated skin, mainly subsequent to the administration of certain chemotherapeutics. Here we present a rare case of RRD induced by the oral multikinase inhibitor sorafenib. Case report A 77-year-old male with hepatocellular carcinoma was irradiated at ten different sites for bone metastases with 20–36 Gray in 5–12 fractions from January to March 2015. Sorafenib 400 mg was administered twice daily from mid-March. One week later the patient presented with fever and erythe... περισσότερα »
IJMS, Vol. 17, Pages 267: The Protective Role of the TOPK/PBK Pathway in Myocardial Ischemia/Reperfusion and H2O2-Induced Injury in H9C2 Cardiomyocytes
[image: ag] T-LAK-cell-originated protein kinase (TOPK) is a PDZ-binding kinase (PBK) that was recently identified as a novel member of the mitogen-activated protein kinase (MAPK) family. It has been shown to play an important role in many cellular functions. However, its role in cardiac function remains unclear. Thus, we have herein explored the biological function of TOPK in myocardial ischemia/reperfusion (I/R) and oxidative stress injury in H9C2 cardiomyocytes. I/R and ischemic preconditioning (IPC) were induced in rats by 3-hour reperfusion after 30-min occlusion of the left a... περισσότερα »
Technologies, Vol. 4, Pages 7: Drilling of Copper Using a Dual-Pulse Femtosecond Laser
The drilling of copper using a dual-pulse femtosecond laser with wavelength of 800 nm, pulse duration of 120 fs and a variable pulse separation time (0.1–150 ps) is investigated theoretically. A one-dimensional two-temperature model with temperature-dependent material properties is considered, including dynamic optical properties and the thermal-physical properties. Rapid phase change and phase explosion models are incorporated to simulate the material ablation process. Numerical results show that under the same total laser fluence of 4 J/cm2, a dual-pulse femtosecond laser with a...περισσότερα »
Molecules, Vol. 21, Pages 258: Typical Monoterpenes as Insecticides and Repellents against Stored Grain Pests
Five monoterpenes naturally occurring in essential oils were tested for their insecticidal and repellent activities against the bruchid beetle Callosobruchus maculatus and the maize weevil Sitophilus zeamais. The monoterpenes were highly efficient as inducers of mortality or repellency against both insect species. They were more efficient in their fumigant activity against C. maculatus than against S. zeamais, while this profile of action was inverted when considering the repellent activities. Eugenol was one the most effective fumigants against both insects and one the most effec... περισσότερα »
Metals, Vol. 6, Pages 43: Temperature Effects on the Tensile Properties of Precipitation-Hardened Al-Mg-Cu-Si Alloys
Because the mechanical performance of precipitation-hardened alloys can be significantly altered with temperature changes, understanding and predicting the effects of temperatures on various mechanical properties for these alloys are important. In the present work, an analytical model has been developed to predict the elastic modulus, the yield stress, the failure stress, and the failure strain taking into consideration the effect of temperatures for precipitation-hardenable Al-Mg-Cu-Si Alloys (Al-A319 alloys). In addition, other important mechanical properties of Al-A319 alloys i... περισσότερα »
Entropy, Vol. 18, Pages 65: New Lagrange Multipliers for the Blind Adaptive Deconvolution Problem Applicable for the Noisy Case
Recently, a new blind adaptive deconvolution algorithm was proposed based on a new closed-form approximated expression for the conditional expectation (the expectation of the source input given the equalized or deconvolutional output) where the output and input probability density function (pdf) of the deconvolutional process were approximated with the maximum entropy density approximation technique. The Lagrange multipliers for the output pdf were set to those used for the input pdf. Although this new blind adaptive deconvolution method has been shown to have improved equalizatio... περισσότερα »
Applied Sciences, Vol. 6, Pages 62: Comfort and Functional Properties of Far-Infrared/Anion-Releasing Warp-Knitted Elastic Composite Fabrics Using Bamboo Charcoal, Copper, and Phase Change Materials
Elastic warp-knitted composite fabrics with far-infrared emissivity and an anion-releasing property were prepared using bamboo charcoal (BC), copper (Cu), and phase-change material (PCM). The functional composite fabric, which was composed of self-made complex yarns with various twisting degrees and material composition, were created using a rotor twister and ring-spinning technique. The fabric structure was diversified by the feeding modes of weft yarn into a crochet-knitting machine. The twist number of complex yarns was optimized by tensile tenacity, twist contraction, and hair...περισσότερα »
Viruses, Vol. 8, Pages 55: Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus Strains
Porcine epidemic diarrhea virus (PEDV), a member of Alphacoronavirus, has caused huge economic losses for the global pork industry recently. The spike (S) protein mediates PEDV entry into host cells. Herein, we investigated the interactions between the S protein and its receptor porcine aminopeptidase N (pAPN) or co-receptor sugars. The C-terminal domain (CTD) of the S1 domain is bound to pAPN. The prototype strain demonstrated similar receptor-binding activity compared with the variant field isolate. Three loops at the tips of the β-barrel domains did not play crucial roles in th... περισσότερα »
Metals, Vol. 6, Pages 41: Picosecond Laser Shock Peening of Nimonic 263 at 1064 nm and 532 nm Wavelength
The paper presents a study on the surface modifications of nickel based superalloy Nimonic 263 induced by laser shock peening (LSP) process. The process was performed by Nd3+:Yttrium Aluminium Garnet (YAG) picosecond laser using the following parameters: pulse duration 170 ps; repetition rate 10 Hz; pulse numbers of 50, 100 and 200; and wavelength of 1064 nm (with pulse energy of 2 mJ, 10 mJ and 15 mJ) and 532 nm (with pulse energy of 25 mJ, 30 mJ and 35 mJ). The following response characteristics were analyzed: modified surface areas obtained by the laser/material interaction wer...περισσότερα »
Remote Sensing, Vol. 8, Pages 164: Spectral Reflectance of Palauan Reef-Building Coral with Different Symbionts in Response to Elevated Temperature
Spectral reflectance patterns of corals are driven largely by the pigments of photosynthetic symbionts within the host cnidarian. The warm inshore bays and cooler offshore reefs of Palau share a variety of coral species with differing endosymbiotic dinoflagellates (genus: Symbiodinium), with the thermally tolerant Symbiodinium trenchii (S. trenchii) (= type D1a or D1-4) predominating under the elevated temperature regimes inshore, and primarily Clade C types in the cooler reefs offshore. Spectral reflectance of two species of stony coral, Cyphastrea serailia (C. serailia) and Pach... περισσότερα »
Econometrics, Vol. 4, Pages 8: Volatility Forecasting: Downside Risk, Jumps and Leverage Effect
We provide empirical evidence of volatility forecasting in relation to asymmetries present in the dynamics of both return and volatility processes. Using recently-developed methodologies to detect jumps from high frequency price data, we estimate the size of positive and negative jumps and propose a methodology to estimate the size of jumps in the quadratic variation. The leverage effect is separated into continuous and discontinuous effects, and past volatility is separated into "good" and "bad", as well as into continuous and discontinuous risks. Using a long history of the S & ... περισσότερα »
Sensors, Vol. 16, Pages 269: An Attachable Electromagnetic Energy Harvester Driven Wireless Sensing System Demonstrating Milling-Processes and Cutter-Wear/Breakage-Condition Monitoring
An attachable electromagnetic-energy-harvester driven wireless vibration-sensing system for monitoring milling-processes and cutter-wear/breakage-conditions is demonstrated. The system includes an electromagnetic energy harvester, three single-axis Micro Electro-Mechanical Systems (MEMS) accelerometers, a wireless chip module, and corresponding circuits. The harvester consisting of magnets with a coil uses electromagnetic induction to harness mechanical energy produced by the rotating spindle in milling processes and consequently convert the harnessed energy to electrical output. ...περισσότερα »
Hydrology, Vol. 3, Pages 10: Comparison between Snow Albedo Obtained from Landsat TM, ETM+ Imagery and the SPOT VEGETATION Albedo Product in a Mediterranean Mountainous Site
Albedo plays an important role in snow evolution modeling quantifying the amount of solar radiation absorbed and reflected by the snowpack, especially in mid-latitude regions with semiarid conditions. Satellite remote sensing is the most extensive technique to determine the variability of snow albedo over medium to large areas; however, scale effects from the pixel size of the sensor source may affect the results of snow models, with different impacts depending on the spatial resolution. This work presents the evaluation of snow albedo values retrieved from (1) Landsat images, L (... περισσότερα »
Administrative Sciences, Vol. 6, Pages 3: Is Self-Regulation Sufficient? Case of the German Transparency Code
The German pharmaceutical industry is stepping ahead with its implementation of a new transparency disclosure code for cooperation between pharmaceutical companies and health care professionals (HCPs) and health care organisations (HCOs). In Germany, this transparency code ("Transparenzkodex") is applicable since January 2015, and data will be publicly available around mid-2016. No empirical work has been done that addresses the impact of the transparency code on cooperation between HCPs, HCOs and the pharmaceutical companies, including the possibilities of competitive analysis of... περισσότερα »
Sensors, Vol. 16, Pages 269: An Attachable Electromagnetic Energy Harvester Driven Wireless Sensing System Demonstrating Milling-Processes and Cutter-Wear/Breakage-Condition Monitoring
An attachable electromagnetic-energy-harvester driven wireless vibration-sensing system for monitoring milling-processes and cutter-wear/breakage-conditions is demonstrated. The system includes an electromagnetic energy harvester, three single-axis Micro Electro-Mechanical Systems (MEMS) accelerometers, a wireless chip module, and corresponding circuits. The harvester consisting of magnets with a coil uses electromagnetic induction to harness mechanical energy produced by the rotating spindle in milling processes and consequently convert the harnessed energy to electrical output. ...περισσότερα »
Hydrology, Vol. 3, Pages 10: Comparison between Snow Albedo Obtained from Landsat TM, ETM+ Imagery and the SPOT VEGETATION Albedo Product in a Mediterranean Mountainous Site
Albedo plays an important role in snow evolution modeling quantifying the amount of solar radiation absorbed and reflected by the snowpack, especially in mid-latitude regions with semiarid conditions. Satellite remote sensing is the most extensive technique to determine the variability of snow albedo over medium to large areas; however, scale effects from the pixel size of the sensor source may affect the results of snow models, with different impacts depending on the spatial resolution. This work presents the evaluation of snow albedo values retrieved from (1) Landsat images, L (... περισσότερα »
Administrative Sciences, Vol. 6, Pages 3: Is Self-Regulation Sufficient? Case of the German Transparency Code
The German pharmaceutical industry is stepping ahead with its implementation of a new transparency disclosure code for cooperation between pharmaceutical companies and health care professionals (HCPs) and health care organisations (HCOs). In Germany, this transparency code ("Transparenzkodex") is applicable since January 2015, and data will be publicly available around mid-2016. No empirical work has been done that addresses the impact of the transparency code on cooperation between HCPs, HCOs and the pharmaceutical companies, including the possibilities of competitive analysis of... περισσότερα »
Compound Profiling and 3D-QSAR Studies of Hydrazone Derivatives with Activity Against Intracellular Trypanosoma cruzi
Publication date: Available online 23 February 2016 *Source:*Bioorganic & Medicinal Chemistry Author(s): Lívia Bandeira Costa, Marcos Veríssimo de Oliveira Cardoso, Gevanio Bezerra de Oliveira Filho, Paulo André Teixeira de Moraes Gomes, José Wanderlan Pontes Espíndola, Thays Gabrielle de Jesus Silva, Pedro Henrique Monteiro Torres, Floriano Paes Silva Junior, Julio Martin, Regina Célia Bressan Queiroz de Figueiredo, Ana Cristina Lima Leite Chagas disease is a tropical disease caused by the parasite Trypanosoma cruzi, which is endemic in Central and South America. Few treatments are ...περισσότερα »
Data on correlation between Aβ42 structural aggregation propensity and toxicity in bacteria
Publication date: June 2016 *Source:*Data in Brief, Volume 7 Author(s): Anita Carija, Susanna Navarro, Salvador Ventura Protein aggregation and amyloid formation is a hallmark of an increasing number of human disorders. Because protein aggregation is deleterious for the cell physiology and results in a decrease in overall cell fitness, it is thought that natural selection acts to purify aggregating proteins during evolution. This data article contains complementary figures and results related to the research article entitled "Selection against toxic aggregation-prone protein sequenc... περισσότερα »
Quantitative super-resolution localization microscopy of DNA in situ using Vybrant® DyeCycle™ Violet fluorescent probe
Publication date: June 2016 *Source:*Data in Brief, Volume 7 Author(s): Dominika Żurek-Biesiada, Aleksander T. Szczurek, Kirti Prakash, Gerrit Best, Giriram K. Mohana, Hyun-Keun Lee, Jean-Yves Roignant, Jurek W. Dobrucki, Christoph Cremer, Udo Birk Single Molecule Localization Microscopy (SMLM) is a recently emerged optical imaging method that was shown to achieve a resolution in the order of tens of nanometers in intact cells. Novel high resolution imaging methods might be crucial for understanding of how the chromatin, a complex of DNA and proteins, is arranged in the eukaryotic c...περισσότερα »
Data on common variants associated with coronary artery disease/myocardial infarction in ethnic Arabs
Publication date: June 2016 *Source:*Data in Brief, Volume 7 Author(s): Salma M. Wakil, Ramesh Ram, Nzioka P. Muiya, Munish Mehta, Editha Andres, Nejat Mazhar, Batoul Baz, Samya Hagos, Maie Alshahid, Brian F. Meyer, Grant Morahan, Nduna Dzimiri The data shows results acquired in a large cohort of 5668 ethnic Arabs involved in a common variants association study for coronary artery disease (CAD) and myocardial infarction (MI) using the Affymetrix Axiom Genotyping platform ("A genome-wide association study reveals susceptibility loci for myocardial infarction/coronary artery disease i...περισσότερα »
Mass-spectrometry analysis of histone post-translational modifications in pathology tissue using the PAT-H-MS approach
Publication date: June 2016 *Source:*Data in Brief, Volume 7 Author(s): Roberta Noberini, Giancarlo Pruneri, Saverio Minucci, Tiziana Bonaldi Aberrant histone post-translational modifications (hPTMs) have been implicated with various pathologies, including cancer, and may represent useful epigenetic biomarkers. The data described here provide a mass spectrometry-based quantitative analysis of hPTMs from formalin-fixed paraffin-embedded (FFPE) tissues, from which histones were extracted through the recently developed PAT-H-MS method. First, we analyzed FFPE samples from mouse spleen... περισσότερα »
Shelf life stability comparison in air for solution processed pristine PDPP3T polymer and doped spiro-OMeTAD as hole transport layer for perovskite solar cell
Publication date: June 2016 *Source:*Data in Brief, Volume 7 Author(s): Ashish Dubey, Nirmal Adhikari, Swaminathan Venkatesan, Shaopeng Gu, Devendra Khatiwada, Qi Wang, Lal Mohammad, Mukesh Kumar, Qiquan Qiao This data in brief includes forward and reverse scanned current density–voltage (J–V) characteristics of perovskite solar cells with PDPP3T and spiro-OMeTAD as HTL, stability testing conditions of perovskite solar cell shelf life in air for both PDPP3T and spiro-OMeTAD as HTL as per the description in Ref. [1], and individual J–V performance parameters acquired with increasing ...περισσότερα »
Remote Sensing, Vol. 8, Pages 166: First Experience with Sentinel-2 Data for Crop and Tree Species Classifications in Central Europe
The study presents the preliminary results of two classification exercises assessing the capabilities of pre-operational (August 2015) Sentinel-2 (S2) data for mapping crop types and tree species. In the first case study, an S2 image was used to map six summer crop species in Lower Austria as well as winter crops/bare soil. Crop type maps are needed to account for crop-specific water use and for agricultural statistics. Crop type information is also useful to parametrize crop growth models for yield estimation, as well as for the retrieval of vegetation biophysical variables using... περισσότερα »
Materials, Vol. 9, Pages 120: Discussion on Microwave-Matter Interaction Mechanisms by In Situ Observation of “Core-Shell” Microstructure during Microwave Sintering
This research aims to deepen the understanding of the interaction mechanisms between microwave and matter in a metal-ceramic system based on in situ synchrotron radiation computed tomography. A special internal "core-shell" microstructure was discovered for the first time and used as an indicator for the interaction mechanisms between microwave and matter. Firstly, it was proved that the microwave magnetic field acted on metal particles by way of inducing an eddy current in the surface of the metal particles, which led to the formation of a "core-shell" microstructure in the metal... περισσότερα »
Sensors, Vol. 16, Pages 273: Investigation of the Performance of HEMT-Based NO, NO2 and NH3 Exhaust Gas Sensors for Automotive Antipollution Systems
We report improved sensitivity to NO, NO2 and NH3 gas with specially-designed AlGaN/GaN high electron mobility transistors (HEMT) that are suitable for operation in the harsh environment of diesel exhaust systems. The gate of the HEMT device is functionalized using a Pt catalyst for gas detection. We found that the performance of the sensors is enhanced at a temperature of 600 °C, and the measured sensitivity to 900 ppm-NO, 900 ppm-NO 2 and 15 ppm-NH 3 is 24%, 38.5% and 33%, respectively, at 600 °C. We also report dynamic response times as fast as 1 s for these three gases. Togeth...περισσότερα »
Materials, Vol. 9, Pages 122: Effect of Friction Stir Process Parameters on the Mechanical and Thermal Behavior of 5754-H111 Aluminum Plates
A study of the Friction Stir Welding (FSW) process was carried out in order to evaluate the influence of process parameters on the mechanical properties of aluminum plates (AA5754-H111). The process was monitored during each test by means of infrared cameras in order to correlate temperature information with eventual changes of the mechanical properties of joints. In particular, two process parameters were considered for tests: the welding tool rotation speed and the welding tool traverse speed. The quality of joints was evaluated by means of destructive and non-destructive tests.... περισσότερα »
IJERPH, Vol. 13, Pages 246: Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells
Dicyclohexyl phthalate (DCHP) is one of the phthalate plasticizers. The objective of the present study was to investigate the effects of DCHP on fetal Leydig cell distribution and function as well as testis development. Female pregnant Sprague Dawley dams orally received vehicle (corn oil, control) or DCHP (10, 100, and 500 mg/kg/day) from gestational day (GD) 12 to GD 21. At GD 21.5, testicular testosterone production, fetal Leydig cell number and distribution, testicular gene and protein expression levels were examined. DCHP administration produced a dose-dependent increase of th... περισσότερα »
IJMS, Vol. 17, Pages 266: Endogenous Sulfur Dioxide Inhibits Vascular Calcification in Association with the TGF-β/Smad Signaling Pathway
The study was designed to investigate whether endogenous sulfur dioxide (SO2) plays a role in vascular calcification (VC) in rats and its possible mechanisms. In vivo medial vascular calcification was induced in rats by vitamin D3 and nicotine for four weeks. In vitro calcification of cultured A7r5 vascular smooth muscle cells (VSMCs) was induced by calcifying media containing 5 mmol/L CaCl2. Aortic smooth muscle (SM) α-actin, runt-related transcription factor 2 (Runx2), transforming growth factor-β (TGF-β) and Smad expression was measured. VC rats showed dispersed calcified nodule... περισσότερα »
Sustainability, Vol. 8, Pages 197: Promoting Sustainability through EMS Application: A Survey Examining the Critical Factors about EMAS Registration in Italian Organizations
One of the tools set by the European Community (EC) to reduce the environmental impact of firms is EMAS Regulation (Regulation (EC) No 1221/2009), setting up an Environmental Management System (EMS), which aims for a continuous improvement of environmental performances. Italy has the highest number of certified organization among all European Member States, accounting for over one thousand registrations. The paper presents the result of a survey conducted through a questionnaire about EMAS implementation and targeted to all Italian registered organizations. Of nearly 1000 organiza...περισσότερα »
Micromachines, Vol. 7, Pages 34: Surface Free Energy Determination of APEX Photosensitive Glass
Surface free energy (SFE) plays an important role in microfluidic device operation. Photosensitive glasses such as APEX offer numerous advantages over traditional glasses for microfluidics, yet the SFE for APEX has not been previously reported. We calculate SFE with the Owens/Wendt geometric method by using contact angles measured with the Sessile drop technique. While the total SFE for APEX is found to be similar to traditional microstructurable glasses, the polar component is lower, which is likely attributable to composition. The SFE was modified at each stage of device fabrica... περισσότερα »
Nutrients, Vol. 8, Pages 108: Metabolic Effects of a 24-Week Energy-Restricted Intervention Combined with Low or High Dairy Intake in Overweight Women: An NMR-Based Metabolomics Investigation
We investigated the effect of a 24-week energy-restricted intervention with low or high dairy intake (LD or HD) on the metabolic profiles of urine, blood and feces in overweight/obese women by NMR spectroscopy combined with ANOVA-simultaneous component analysis (ASCA). A significant effect of dairy intake was found on the urine metabolome. HD intake increased urinary citrate, creatinine and urea excretion, and decreased urinary excretion of trimethylamine-N-oxide (TMAO) and hippurate relative to the LD intake, suggesting that HD intake was associated with alterations in protein ca...περισσότερα »
IFNL4 genotype is associated with jaundice and elevated aminotransferase levels during acute HCV infection: findings from the InC3 Collaborative
Open Forum Infectious Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/1mUySlh via IFTTT
Atorvastatin and fluvastatin are associated with dose-dependent reductions in cirrhosis and HCC, among patients with HCV Results from ERCHIVES
Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1TCsk90 via IFTTT
Diagnostic differentiation of pancreatic neuroendocrine tumor from other neoplastic solid pancreatic lesions during endoscopic ultrasound-guided fine-needle aspiration
Pancreas from #Medicine via ola Kala on Inoreader http://ift.tt/1mUyRh5 via IFTTT
Randomized, double-blind, placebo-controlled phase III trial of apatinib in patients with chemotherapy-refractory advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction
Journal of Clinical Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/1TCshds via IFTTT
Evolving strategy for HCV testing in an Italian tertiary care hospital
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Pulsed dye laser treatment of capillary malformations in infants at 2-weekly versus 3-monthly intervals, reducing the need for general anaesthesia
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Capillary malformations (CM) cause significant psychosocial complications. Pulsed dye laser (PDL) treatment at 6–12-weekly intervals under general anaesthesia (GA) commencing in infants at 6 months of age remains the standard of care in order to achieve maximal improvement prior to school age. The safety of repeated GA in children is controversial. Shortening the time […]
Biorhythms, deciduous enamel thickness, and primary bone growth: a test of the Havers-Halberg Oscillation hypothesis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Across mammalian species, the periodicity with which enamel layers form (Retzius periodicity) in permanent teeth corresponds with average body mass and the pace of life history. According to the Havers–Halberg Oscillation hypothesis (HHO), Retzius periodicity (RP) is a manifestation of a biorhythm that is also expressed in lamellar bone. Potentially, these links provide a […]
Inquiry launched into St Vincent’s Hospital chemotherapy dosage scandal – ABC Online
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
ABC Online Inquiry launched into St Vincent’s Hospital chemotherapy dosage scandal ABC Online NATALIE DUGDALE, WIFE OF CANCER PATIENT: I couldn’t believe it. I was gobsmacked and that, because straight away I knew that Ken fell into that time period. I knew that he was receiving the low-dose chemotherapy with the radiation. So I was […]
Redox Status and Proteostasis in Ageing and Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
PDF´s sobre SERUM AND GLUCOCORTICOID REGULATED KINASE 1. … The serum– and glucocorticoid–inducible kinase SGK1 regulates several … from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mUD5Ft via IFTTT
The role of mutations in the SCN5A gene in cardiomyopathies
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: Available online 23 February 2016 Source:Biochimica et Biophysica Acta (BBA) – Molecular Cell Research Author(s): Elena Zaklyazminskaya, Sergei Dzemeshkevich The SCN5A gene encodes the alpha-subunit of the Nav1.5 ion channel protein, which is responsible for the sodium inward current (INa). Since 1995 several hundred mutations in this gene have been found to be […]
Polymicrobial Pituitary Abscess Predominately Involving Escherichia coli in the Setting of an Apoplectic Pituitary Prolactinoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Pituitary abscess is a rare intracranial infection that can be life-threatening if not appropriately diagnosed and treated upon presentation. The most common presenting symptoms include headache, anterior pituitary hypofunction, and visual field disturbances. Brain imaging with either computed tomography or magnetic resonance imaging usually reveals intra- or suprasellar lesion(s). Diagnosis is typically confirmed intra- or […]
Chemistry and Functionality of Bioactive Compounds Present in Persimmon
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Extensive research has related the consumption of persimmon with the reduced risk of various diseases and particularly highlighted the presence of bioactive phenolic compounds for their therapeutic properties. Major phenolic compounds present in persimmon are ferulic acid, p-coumaric acid, and gallic acid. β-Cryptoxanthin, lycopene, β-carotene, zeaxanthin, and lutein are important carotenoids having antioxidant potential. They […]
Tamoxifen Promotes Axonal Preservation and Gait Locomotion Recovery after Spinal Cord Injury in Cats
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
We performed experiments in cats with a spinal cord penetrating hemisection at T13-L1 level, with and without tamoxifen treatment. The results showed that the numbers of the ipsilateral and contralateral ventral horn neurons were reduced to less than half in the nontreated animals compared with the treated ones. Also, axons myelin sheet was preserved to […]
Overexpression of AaWRKY1 Leads to an Enhanced Content of Artemisinin in Artemisia annua
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Artemisinin is an effective component of drugs against malaria. The regulation of artemisinin biosynthesis is at the forefront of artemisinin research. Previous studies showed that AaWRKY1 can regulate the expression of ADS, which is the first key enzyme in artemisinin biosynthetic pathway. In this study, AaWRKY1 was cloned, and it activated ADSpro and CYPpro in […]
A Comprehensive Updated Review of Pharmaceutical and Nonpharmaceutical Treatment for NAFLD
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the western world with prevalence of 20–33%. NAFLD comprises a pathological spectrum. Nonalcoholic fatty liver (NAFL) is at one end and consists of simple hepatic steatosis. On the contrary, nonalcoholic steatohepatitis (NASH) consists of steatosis, inflammation, and ballooning degeneration and can progress to […]
Correspondence Tracheobronchial transplantation: The Royal Swedish Academy of Sciences’ concerns
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
On behalf of The Royal Swedish Academy of Sciences, we wish to express our concerns regarding a paper by Philipp Jungebluth and colleagues, “Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study”,1 which was published in The Lancet on Dec 10, 2011. Available information shows that the paper does not present the condition of […]
Biorhythms, deciduous enamel thickness, and primary bone growth: a test of the Havers-Halberg Oscillation hypothesis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Across mammalian species, the periodicity with which enamel layers form (Retzius periodicity) in permanent teeth corresponds with average body mass and the pace of life history. According to the Havers–Halberg Oscillation hypothesis (HHO), Retzius periodicity (RP) is a manifestation of a biorhythm that is also expressed in lamellar bone. Potentially, these links provide a […]
Spatial and temporal analysis of tuberculosis in Zhejiang Province, China, 2009-2012
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Background Tuberculosis (TB) is an infectious disease of major public health concern. The disease has demonstrated large space-time variations. This study aims to explore the space-time dynamics of TB cases in an economically and geographically dynamic province in China with specific references of TB control for policy makers. Methods Data on all reported TB […]
Polycyclic aromatic hydrocarbons (PAHs) in atmospheric PM2.5 around 2013 Asian Youth Games period in Nanjing
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: 15 June 2016 Source:Atmospheric Research, Volumes 174–175 Author(s): Xuxu Li, Shaofei Kong, Yan Yin, Li Li, Liang Yuan, Qi Li, Hui Xiao, Kui Chen Eighteen polycyclic aromatic hydrocarbons (PAHs) in PM2.5 collected near the Nanjing Olympic Sports Center across the Asian Youth Games (AYG) period (from August 2 to August 28, 2013) were […]
IL-4 promotes asymmetric dimethylarginine accumulation, oxo-nitrative stress, and hypoxic response–induced mitochondrial loss in airway epithelial cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: Available online 23 February 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Bijay Pattnaik, Manish Bodas, Naveen Kumar Bhatraju, Tanveer Ahmad, Richa Pant, Randeep Guleria, Balaram Ghosh, Anurag Agrawal BackgroundObesity is known to increase asthma risk and severity. Increased levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are associated with […]
Nonsteroidal anti-inflammatory–induced inhibition of signal transducer and activator of transcription 6 (STAT-6) phosphorylation in aspirin-exacerbated respiratory disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: Available online 23 February 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Rohit K. Katial, Michael Martucci, Trever Burnett, Anna Faino, Lindsay Finkas, Sucai Liu, Rafeul Alam BackgroundAspirin desensitization provides long-term clinical benefits. The exact mechanisms of aspirin desensitization are not clearly understood.ObjectiveWe sought to evaluate the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) […]
Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-to-severe asthma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: Available online 23 February 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Eric D. Bateman, Udo-Michael Goehring, Frank Richard, Henrik Watz BackgroundRoflumilast, a selective phosphodiesterase 4 inhibitor, has been shown to provide modest improvements in lung function in patients with mild-to-moderate asthma, but its efficacy in patients with moderate-to-severe asthma has not been […]
Randomized phase 1 study of the phosphatidylinositol 3-kinase δ inhibitor idelalisib in patients with allergic rhinitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: Available online 23 February 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Friedrich Horak, Kamal D. Puri, Bart H. Steiner, Leanne Holes, Guan Xing, Petra Zieglmayer, René Zieglmayer, Patrick Lemell, Albert Yu BackgroundPhosphatidylinositol 3-kinase p110δ isoform (PI3K p110δ) activity is essential for mast cell activation, suggesting that inhibition of PI3K p110δ might be […]
