[Head and neck paragangliomas : An interdisciplinary challenge].
*[Head and neck paragangliomas : An interdisciplinary challenge].* HNO. 2015 Nov 4; Authors: Künzel J, Bahr K, Hainz M, Rossmann H, Matthias C Abstract BACKGROUND: Current treatment strategies for head and neck paragangliomas are moving away from radical resection and toward surgical tumor reduction, in order to preserve function and reduce morbidity. Radiotherapy modalities are alternative primary treatment options. MATERIALS AND METHODS: A PubMed search of the relevant literature on genetics and treatment of head and neck paragangliomas was conducted. RESULTS: The rapid progress... περισσότερα »
[Tonsillectomy in adults : Length of hospital stay has no influence on the frequency of postoperative hemorrhage].
*[Tonsillectomy in adults : Length of hospital stay has no influence on the frequency of postoperative hemorrhage].* HNO. 2015 Nov 4; Authors: Coordes A, Soudry J, Hofmann VM, Lenarz M Abstract BACKGROUND: Tonsillectomies (TE) in Germany are traditionally performed during inpatient hospital stays. Socioeconomic changes in the healthcare system have resulted in shorter hospital stays. OBJECTIVES: The aim of the study was to investigate whether a shorter hospital stay of 2 days leads to increased postoperative bleeding after TE. Factors affecting the duration of hospitalization wer...περισσότερα »
Number of infants who were able to avoid tracheostomy or achieve decannulation, who were able to avoid placement or achieve removal of a gastrostomy tube, and in whom there were no intraoperative complications, no open-bite deformity, no malocclusion, no asymmetry, and no postoperative complications.
External Distractor Use Prior to Mandibular Distraction for Pierre Robin Sequence and Stickler Syndrome: This observational study evaluates external distractor use and the need for preoperative computed tomographic imaging in infants with isolated Pierre Robin sequence or Stickler syndrome who are undergoing mandibular distraction osteogenesis. *Importance* Computed tomographic (CT) scans are often obtained before mandibular distraction osteogenesis in patients with isolated Pierre Robin sequence. There is concern regarding the risk of radiation exposure from CT in children. *Obje... περισσότερα »
Electronic Data Repository for Patients With Nasal Obstruction
Electronic Data Repository for Patients With Nasal Obstruction: The data collection tool described herein contains a standardized nasal examination, operative details, and patient-reported outcomes measures for patients with nasal obstruction. The data collection tool described herein contains a standardized nasal examination, operative details, and patient-reported outcomes measures for patients with nasal obstruction. Outcomes research for patients with nasal obstruction has been hampered by infrequent objective and quantitative evaluation of nasal function.1 The Nasal Obstructio... περισσότερα »
Salivary gland FNA: New markers and new opportunities for improved diagnosis
Salivary gland FNA: New markers and new opportunities for improved diagnosis: Salivary gland fine-needle aspiration represents 1 of the most challenging areas of cytopathology; however, the discovery of several novel and/or next-generation immunocytochemical and molecular markers for salivary gland tumors has resulted in greater diagnostic accuracy in cytologic diagnosis. In this commentary, recent advances in salivary gland cytopathology are reviewed with a focus on salivary gland tumors associated with gene rearrangements.
Although polysomnographic (PSG) testing is the gold standard for the diagnosis of obstructive sleep apnea syndrome (OSAS) in children, the number of pediatric sleep laboratories is limited. Developing new screening methods for identifying OSAS may reduce the need for PSG testing.
Pediatric Sleep Apnea Syndrome in Limited-Resource Settings: This study, conducted over a 10-month period, uses the clinical sleep record and McGill oximetry score in tandem to predict obstructive sleep apnea syndrome in children and found that the combined use has moderate success when polysomnographic testing is not an option. *Importance* Although polysomnographic (PSG) testing is the gold standard for the diagnosis of obstructive sleep apnea syndrome (OSAS) in children, the number of pediatric sleep laboratories is limited. Developing new screening methods for identifying OSAS...περισσότερα »
Ethics of Disclosure and Counseling of Patients With Thyroid Cancer
Ethics of Disclosure and Counseling of Patients With Thyroid Cancer: This Viewpoint discusses the importance of shared decision-making and observation protocol in patients with thyroid cancer. This Viewpoint discusses the importance of shared decision-making and observation protocol in patients with thyroid cancer. The ethical basis for the interactions between physicians and patients is primarily grounded in the principles of beneficence and respect for persons. Beneficence emphasizes the importance of acting in such a way that patients will benefit from the interaction. The princi... περισσότερα »
Childhood hearing disorders associated with tinnitus in adulthood include sensorineural hearing loss, chronic suppurative otitis media, and hearing loss associated with a history of recurrent acute otitis media. After adjustment for the adult hearing threshold, none of the childhood hearing disorders was positively associated with tinnitus. Hence, it appears that these significant associations are mediated or transmitted through adult hearing loss.
Association Between Childhood Hearing Disorders and Tinnitus in Adults: This longitudinal study evaluates the effect of childhood hearing disorders on the occurrence of tinnitus in adulthood and found that childhood disorders were not positively associated with tinnitus when adjusted for adult hearing threshold. examined in longitudinal cohort studies. *Objectives* To determine the association between different types of childhood hearing loss and tinnitus in adulthood and evaluate whether tinnitus risk is mediated by adult hearing loss. *Design, Setting, and Participants* Popula... περισσότερα »
Neutralizing TAF-derived HGF with ficlatuzumab effectively mitigates c-Met signaling and decreases HNSCC proliferation, migration, and invasion. Thus, ficlatuzumab effectively mitigates stromal influences on HNSCC progression.
Fibroblast-Facilitated Head and Neck Cancer and Ficlatuzumab: This Original Investigation demonstrates that neutralizing tumor-associated fibroblast–derived hepatocyte growth factor with ficlatuzumab effectively mitigates c-Met signaling and decreases HNSCC proliferation, migration, and invasion. *Importance* Ficlatuzumab can be used to treat head and neck squamous cell carcinoma (HNSCC) by inhibiting c-Met receptor-mediated cell proliferation, migration, and invasion. *Objective* To understand the effect of ficlatuzumab on HNSCC proliferation, migration, and invasion. *Design, S...περισσότερα »
Surgery for lymph node metastases of medullary thyroid carcinoma: A review
Surgery for lymph node metastases of medullary thyroid carcinoma: A review: Medullary thyroid carcinoma (MTC) is a neuroendocrine malignancy of the thyroid C cells that occurs in hereditary and sporadic clinical settings. Metastatic spread commonly occurs to cervical and mediastinal lymph nodes. MTC cells do not concentrate radioactive iodine and are not sensitive to hormonal manipulation, and therefore surgery is the most effective option for curative therapy, reduction in tumor burden, or effective palliation. In patients undergoing preventative surgery for hereditary MTC, central... περισσότερα »
Undiagnosed Hepatocellular Carcinoma Presenting as Nasal Metastases
Undiagnosed Hepatocellular Carcinoma Presenting as Nasal Metastases: Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with up to half of cases suffering from extrahepatic metastasis in the later stages of the disease. Commonly reported and encountered metastatic sites include the lymph nodes, lung, bone, and adrenal glands. This is an effort to throw a spotlight on a rare case of metastatic HCC which presented to us as two distinct lesions in the nose. It focuses on the presentation and the steps that were taken to reach this rare and unusual diagnosis. It sparks ...περισσότερα »
The Effect of Transconjunctival Blepharoplasty on Margin Reflex Distance 2
The Effect of Transconjunctival Blepharoplasty on Margin Reflex Distance 2: Abstract BackgroundThe objective of this study was to determine the effects of lower eyelid transconjunctival blepharoplasty (TCB) on lower eyelid position. MethodsTransconjunctival blepharoplasty was performed alone in 15 lower eyelids without simultaneous canthoplasty or upper eyelid procedure. In this study, blepharoplasty was performed by the transconjunctival approach without removal of skin. Four eyes received TCB plus Erbium laser, two patients received TCB plus trichloroacetic acid peel (TCA), an...περισσότερα »
Outcomes of Tissue Expander Application for Scalp Reconstruction in Extensive Aplasia Cutis Congenita
Outcomes of Tissue Expander Application for Scalp Reconstruction in Extensive Aplasia Cutis Congenita: Abstract IntroductionAplasia cutis congenita (ACC) is a rare congenital disorder. The purpose of this study was to present outcomes of tissue expander application for scalp reconstruction in extensive ACC. Patient/MethodsIn this retrospective study, medical records were reviewed for six patients who underwent serial tissue expander application for scalp reconstruction in ACC between 2000 and 2015. Patient average age was 14.5 (range, 4–25 years). One of the six cases had front...περισσότερα »
Inorganic Selenium Supplements
Rumen Microorganisms Decrease Bioavailability of Inorganic Selenium Supplements: AbstractDespite the availability of selenium (Se)-enriched trace mineral supplements, we have observed low Se status in cattle and sheep offered traditional inorganic Se supplements. Reasons for this may include inadequate intake or low bioavailability of inorganic Se sources. The objective of this study was to determine whether rumen microorganisms (RMO) alter the bioavailability of Se sources commonly used in Se supplements. Rumen microorganisms were isolated from ewes (*n* = 4) and incubated ex viv...περισσότερα »
Aortic Involvement in Behçet's Disease
Endovascular Repair and Adjunctive Immunosuppressive Therapy of στο ScienceDirect Publication: European Journal of Vascular and Endovascular Surgery Publication date: November 2015 *Source:*European Journal of Vascular and Endovascular Surgery, Volume 50, Issue 5 Author(s): O. Balcioglu, S. Ertugay, H. Bozkaya, M. Parildar, H. Posacioglu ObjectivesAortic aneurysm is a serious problem in Behçet's disease, but open surgical therapy carries the risk of recurrent pseudoaneurysm. Here the outcomes of endovascular repair and adjunctive immunosuppressive therapy for aortic disease in Behçet'... περισσότερα »
Thoracolaparoscopic esophagectomy with cervical anastomosis with McKeown esophagectomy for middle esophageal cancer
Comparison of thoracolaparoscopic esophagectomy with cervical anastomosis with McKeown esophagectomy for middle esophageal cancer: Abstract BackgroundIn China, the middle esophageal squamous cell cancer is the most common tumor type, and Mckeown esophagectomy (ME) is preferably adopted by thoracic surgeon. But, the surgical trauma of ME is great. Thoracolaparoscopic esophagectomy (TE) was developed to decrease the operative stress; however, the safety and efficacy were not defined. In this study, clinical outcomes were compared between patients who received ME and TE. MethodsTh... περισσότερα »
Chemotherapy promotes tumour cell hybridization in vivo
Chemotherapy promotes tumour cell hybridization in vivo: AbstractSpontaneous cell-cell fusion has been recognized to be an important mechanism for tissue and organ development and repair. In cancer, cell fusion is critically involved in tumourigenesis, metastasis and drug resistance, as illustrated by in vitro experiments. However, there has been no direct detection of tumour cell fusion or hybridization in an in vivo tumour environment, and the features of hybridized cells under selective pressures, such as chemotherapy, are unknown. Here, we expressed two fluorescent marker prote... περισσότερα »
Stereotactic intracavitary brachytherapy with P-32 for cystic craniopharyngiomas in children
Stereotactic intracavitary brachytherapy with P-32 for cystic craniopharyngiomas in children: Abstract PurposeAlthough microsurgery remains the first-line treatment, gross total resection of cystic craniopharyngeomas (CP) is associated with significant morbidity and mortality and the addition of external irradiation to subtotal resection proves to achieve similar tumor control. However, concern regarding long-term morbidity associated with external irradiation in children still remains. With this retrospective analysis, the authors emphasize intracavitary brachytherapy using phosp... περισσότερα »
Autologous Fat Transfer for Esthetic Contouring of Face in Posttraumatic Nonfunctional Maxillofacial Deformities
Autologous Fat Transfer for Esthetic Contouring of Face in Posttraumatic Nonfunctional Maxillofacial Deformities: Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0035-1566163 The transfer of autologous fat has been performed since the 1890s; however, its popularity has increased owing to better understanding of fat harvesting and processing techniques. In this article, fat grafting procedure has been used to correct posttraumatic facial deformities in 25 cases. As healing of grafted fat is unpredictable, we have used longer follow-up of 2 years. Evaluation was performed usi... περισσότερα »
Dislocation of Fractured Mandibular Condyle
A Rare Case Report of an Unusual Dislocation of Fractured Mandibular Condyle: Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0035-1566161 Several cases have been reported regarding superolateral, posterior, or superior dislocation of mandibular condyle. The anteromedial dislocation of fractured condyle is the most common among all. This article reports an unusual and unique case of dislocated fractured mandibular condyle wherein the fractured left condylar head was dislocated to the left anatomic angle of mandible. We have not found a single such case in the world English ...περισσότερα »
Deformation of a Titanium Calvarial Implant following Trauma: A Case Report
Deformation of a Titanium Calvarial Implant following Trauma: A Case Report: Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0035-1567810 Alloplastic material is widely used for the reconstruction of calvarial defects. The objective of this article is to describe the effect of mechanical impact on a titanium calvarial implant and to discuss mechanical properties of alternative implant materials. The patient is a 19-year-old man who was involved in a traffic accident and underwent decompressive craniectomy for an extensive subdural hematoma. Reimplantation of the skull flap... περισσότερα »
DDX3, a potential target for cancer treatment
DDX3, a potential target for cancer treatment: AbstractRNA helicases are a large family of proteins with a distinct motif, referred to as the DEAD/H (Asp-Glu-Ala-Asp/His). The exact functions of all the human DEAD/H box proteins are unknown. However, it has been consistently demonstrated that these proteins are associated with several aspects of energy-dependent RNA metabolism, including translation, ribosome biogenesis, and pre-mRNA splicing. In addition, DEAD/H box proteins participate in nuclear-cytoplasmic transport and organellar gene expression. A member of this RNA helicase ...περισσότερα »
Teaching New Words to Children With Specific Language Impairment Using Interactive Book Reading
Teaching New Words to Children With Specific Language Impairment Using Interactive Book Reading: This article will review the evidence base for interactive book reading to facilitate new word learning for preschool and school age children. Methods from an ongoing clinical trial of interactive book reading will be described to illustrate how this treatment approach can be delivered at a high intensity to children with specific language impairment (SLI). Preliminary results from this clinical trial indicate that children with SLI need a modified intensity that is three times higher th... περισσότερα »
Learning and Remembering New Words: Clinical Illustrations From Children With Specific Language Impairment
Learning and Remembering New Words: Clinical Illustrations From Children With Specific Language Impairment: The learning of a new word involves at least two processes: learning from input and memory evolution in the absence of input. The authors will review the literature and describe the relationship between these two processes and novel word learning by children with specific language impairment (SLI). Cases from an ongoing preliminary clinical trial of word learning in kindergarten children with SLI will serve as clinical illustrations. In particular, one case will be used to dem... περισσότερα »
Selecting Vocabulary Words to Teach
Selecting Vocabulary Words to Teach: Although speech-language pathologists may understand the importance of vocabulary for oral language, listening, and reading comprehension and the need for vocabulary instruction, they may not have a clear rationale for selecting specific words to teach. The purpose of this article is to review different strategies for selecting vocabulary words for direct instruction and to discuss the pros and cons of each strategy.
Morphological Awareness Intervention to Improve Vocabulary and Reading Success
Morphological Awareness Intervention to Improve Vocabulary and Reading Success: The application of a morphological awareness strategy can be used to improve vocabulary and reading skills in school-age students. The purpose of this article is to briefly review the evidence for using a morphological awareness strategy and provide an example for how a speech-language pathologist can integrate such a skill in practice.
Age-related inhibitory deficit, or lack of familiarity benefit? Evidence from letter identification among visual distractors
Age-related inhibitory deficit, or lack of familiarity benefit? Evidence from letter identification among visual distractors: AbstractAge-related deficits in processing complex visual scenes are often attributed to age-related declines in the cognitive abilities required for such tasks. For example, poorer or slower performance of a complex task in the presence of distractor items is often attributed to an age-related deficit in the ability to inhibit the processing of irrelevant information. To investigate the relative contributions of sensory and cognitive factors in such tasks, ... περισσότερα »
Effect of explicit dimensional instruction on speech category learning
Effect of explicit dimensional instruction on speech category learning: AbstractLearning nonnative speech categories is often considered a challenging task in adulthood. This difficulty is driven by cross-language differences in weighting critical auditory dimensions that differentiate speech categories. For example, previous studies have shown that differentiating Mandarin tonal categories requires attending to dimensions related to pitch height and direction. Relative to native speakers of Mandarin, the pitch direction dimension is underweighted by native English speakers. In the... περισσότερα »
Streptococcal Infections
Also called: Strep On this page Basics - Summary - Start Here - Diagnosis/Symptoms - Prevention/Screening Learn More - Related Issues - Specific Conditions See, Play and Learn - No links available Research - Clinical Trials - Journal Articles Resources - Find an Expert For You - Children - Teenagers - Women - Patient Handouts Summary Strep is short for Streptococcus, a type of bacteria. There are two types: group A and group B. Group A strep causes - Strep throat - a sore, red throat, sometimes with white s... περισσότερα »
S. pyogenes human pharyngitis S. agalactiae human, cattle neonatal meningitis and sepsis S. equisimilis human, animals endocarditis, bacteremia, pneumonia, meningitis, respiratory infections S. bovis human, animals biliary or urinary tract infections, endocarditis S. anginosus human, animals subcutaneous/organ abscesses, meningitis, respiratory infections S. sanguinis human endocarditis, dental caries S. suis swine meningitis S. mitis human endocarditis S. mutans human dental caries S. pneumoniae human pneumonia
*Streptococcus* From Wikipedia, the free encyclopedia Not to be confused with Staphylococcus. *Streptococcus*[image: Streptococci.jpg]Scientific classificationKingdom: BacteriaPhylum:FirmicutesClass:Bacilli[1]Order:LactobacillalesFamily: StreptococcaceaeGenus:*Streptococcus* Rosenbach, 1884Species[2] - *Streptococcus agalactiae* - *Streptococcus anginosus* - *Streptococcus bovis* - *Streptococcus canis* - *Streptococcus constellatus* - *Streptococcus dysgalactiae* - *Streptococcus equinus* - *Streptococcus iniae* - *Streptococcus intermedius* - *Streptococ... περισσότερα »
The Management of Low-Risk Papillary Microcarcinoma of the Thyroid by Active Surveillance Versus Immediate Surgery
Incidences of Unfavorable Events in από Hitomi Oda στο liebertpub1 Thyroid , Vol. 0, No. 0. Author information Hitomi Oda,1 Akira Miyauchi,1 Yasuhiro Ito,1,2 Kana Yoshioka,3 Ayako Nakayama,3 Hisanori Sasai,3Hiroo Masuoka,1 Tomonori Yabuta,1 Mitsuhiro Fukushima,1 Takuya Higashiyama,1 Minoru Kihara,1Kaoru Kobayashi,1 and Akihiro Miya1 1Department of Surgery, Kuma Hospital, Kobe, Japan. 2Clinical Trial Management Center, Kuma Hospital, Kobe, Japan. 3Department of Head and Neck Surgery, Kuma Hospital, Kobe, Japan. © Oda *et al.* 2015; Published by Mary Ann Liebert, Inc. This Open Access a... περισσότερα »
Update on Brain tumors: New developments in neuro-oncologic diagnosis and treatment, and impact on rehabilitation strategies
Update on Brain tumors: New developments in neuro-oncologic diagnosis and treatment, and impact on rehabilitation strategies: Brain tumors can be a source of functional impairment to patients due to neurologic sequelae associated with the tumor itself as well as treatment side effects. As a result, many of these patients may require rehabilitation services. Surgery, chemotherapy, and radiotherapy have been longstanding, primary treatment modalities in the management of brain tumors, though these treatments continue to evolve given new developments in research and technology. A bette...περισσότερα »
A review of current progress in acquired cholesteatoma management
A review of current progress in acquired cholesteatoma management: AbstractThe aim of this study was to review recent advances in the management of acquired cholesteatoma. All papers referring to acquired cholesteatoma management were identified in Medline via OVID (1948 to December 2013), PubMed (to December 2013), and Cochrane Library (to December 2013). A total of 86 papers were included in the review. Cholesteatoma surgery can be approached using either a canal wall up (CWU) or canal wall down (CWD) mastoidectomy with or without reconstruction of the middle ear cleft. In recent...περισσότερα »
Reduced dosage of bevacizumab in treatment of vestibular schwannomas in patients with neurofibromatosis type 2
Reduced dosage of bevacizumab in treatment of vestibular schwannomas in patients with neurofibromatosis type 2: AbstractNeurofibromatosis type 2 (NF2) is a tumor suppressor syndrome associated with vestibular schwannomas and other benign tumors of the central nervous system. Bevacizumab is used for treatment of progressive vestibular schwannomas, with the intent to reduce tumor size or preserve/improve hearing. Prolonged treatment can cause side effects such as hypertension and proteinuria, which can be cause for discontinuation of therapy. We report on 3 patients who were treated ... περισσότερα »
Monaural or binaural sound deprivation in postlingual hearing loss
: Cochlear implant in the worse ear από Andrea Canale, Giulia Dalmasso, Federico Dagna, Michelangelo Lacilla, Carla Montuschi, Rosalba Di Rosa, Roberto Alberaστο The Laryngoscope Objectives/Hypothesis To determine whether speech recognition scores (SRS) differ between adults with long-term auditory deprivation in the implanted ear and adults who received cochlear implant (CI) in the nonsound-deprived ear, either for hearing aid–assisted or due to rapidly deteriorating hearing loss. Study Design Retrospective study. Methods Speech recognition scores at evaluations (3 and 14 months postim... περισσότερα »
Nasopharyngectomy using partial maxillectomy approach
Long-term outcomes of από Li Shia Ng, Chwee Ming Lim, Kwok Seng Loh στο The Laryngoscope Objectives/Hypothesis To determine the long-term outcomes of a prospective cohort of 20 patients who had nasopharyngectomy using an open partial-maxillectomy approach. Method A prospective cohort study of the surgical outcomes of patients with recurrent T1 (rT1) and rT2 nasopharyngeal carcinoma recurrence. Results There were 14 male and six female patients. The mean age was 49 years. The mean duration of follow-up was 60.4 months. All of the surgical margins were free of malignancy. Ten patients (5... περισσότερα »
Clinicopathologic Features Associated With Human Papillomavirus/p16 in Patients With Metastatic Squamous Cell Carcinoma
of the Anal Canal: Background. The incidence of anal carcinoma in the U.S. continues to increase steadily, and infection with the human papillomavirus (HPV) is an established risk factor for the development of anal carcinoma. However, the clinicopathologic characteristics of patients with metastatic squamous cell carcinoma of the anal canal according to HPV status have not yet been defined. Materials and Methods. The records of patients treated for metastatic squamous cell carcinoma of the anal canal at the MD Anderson Cancer Center from June 2005 to August 2013 were reviewed. Th...περισσότερα »
Gianni Bonadonna: A Tribute
Gianni Bonadonna: A Tribute: Gianni Bonadonna: A Tribute 1. Stephan Tanneberger and 2. Franco Pannuti -Author Affiliations 1. Fondazione ANT Italia, Bologna, Italy 1. Correspondence: Stephan Tanneberger, M.D., Ph.D., Hauptstrasse 11, 17406 Rankwitz/Liepe, Germany. Telephone: 49-38372-76169; E-Mail: h.s.tanneberger@gmx.de - Received September 15, 2015. - Accepted September 18, 2015. - Published online before print October 8, 2015. - Disclosures of potential conflicts of interest may be found at the end of this article. On September 6, 2015... περισσότερα »
Gemcitabine and Docetaxel in Combination With Pazopanib for the Neoadjuvant Treatment of Soft Tissue Sarcomas
A Phase Ib/II Study of Gemcitabine and Docetaxel in Combination With Pazopanib for the Neoadjuvant Treatment of Soft Tissue Sarcomas: Lessons Learned Our results highlight some of the challenges in the management of soft tissue sarcomas, which requires close cooperation between surgeons and medical oncologists and a careful selection of patients. The incidence of hepatotoxicity was a concerning finding and had been previously reported in patients treated with pazopanib. Although pharmacokinetic analysis was not part of this study, concomitant treatment with pazopanib has been recen... περισσότερα »
Supportive and Palliative Care Referral Among Hematologic and Solid Tumor Oncology Specialists
Attitudes and Beliefs Toward Supportive and Palliative Care Referral Among Hematologic and Solid Tumor Oncology Specialists: Background. Palliative care (PC) referrals are often delayed for patients with hematologic malignancies. We examined the differences in attitudes and beliefs toward PC referral between hematologic and solid tumor specialists and how their perception changed with use of the service name "supportive care" (SC). Materials and Methods. We randomly surveyed 120 hematologic and 120 solid tumor oncology specialists at our tertiary care cancer center to examine their...περισσότερα »
Phase II Trial of Nilotinib in Patients With Metastatic Malignant Melanoma Harboring KIT Gene Aberration
Phase II Trial of Nilotinib in Patients With Metastatic Malignant Melanoma Harboring KIT Gene Aberration: A Multicenter Trial of Korean Cancer Study Group (UN10-06): Background. KIT has been suggested to be a potential therapeutic target for malignant melanoma. We evaluated the antitumor activity and safety of the KIT inhibitor nilotinib in metastatic melanoma patients harboring *KIT* gene mutations or amplifications. Methods. We conducted a phase II multicenter trial of nilotinib in metastatic malignant melanoma with *KIT* mutations or amplifications. Patients received 400 mg ora... περισσότερα »
A Holistic Approach to Cancer Health Disparities
A Holistic Approach to Cancer Health Disparities: *The following is the fourth in a series of posts from senior NCI scientists and leaders on *NCI’s Annual Plan and Budget Proposal for Fiscal Year (FY) 2017*, which was submitted to the President on September 17, 2015. The proposal provides an overview of NCI’s priorities and key initiatives and the institute’s funding request for the President to consider in formulating his own FY 2017 budget proposal.* *In this fourth post, L. Michelle Bennett, Ph.D., director of the NCI Center for Research Strategies; Worta McCaskill-Stevens, M.D... περισσότερα »
Severe Obstructive Sleep Apnea Induced by Neck Radiotherapy Treated with an Oral Device
Two Cases of Severe Obstructive Sleep Apnea Induced by Neck Radiotherapy Treated with an Oral Device: AbstractSleep apnea has been shown to be more prevalent in patients who underwent radiotherapy and or surgery for head and neck cancer. Here we describe two cases of severe OSAS induced by surgery and radiotherapy, treated by Mandibular Advancing Devices as an alternative option to continuous positive airway pressure.
Staged laryngeal reconstruction with a prefabricated flap for radiation recurrent glottic carcinoma
Staged laryngeal reconstruction with a prefabricated flap for radiation recurrent glottic carcinoma: Objectives/Hypothesis Although salvage total laryngectomy remains the definitive approach to recurrent/persistent glottic cancer following failed radiation therapy for favorable early-stage disease, it comes at the price of a permanent laryngostome and an impact on quality of life. We describe a three-stage method of laryngeal reconstruction for salvage partial laryngectomy to address the unique challenges of operating on radiation recurrent/persistent cancer. Study Design This was ... περισσότερα »
Group differences in MD Anderson Dysphagia Inventory (MDADI) scores among head and neck cancer (HNC) patients
What is a clinically relevant difference in MDADI scores between groups of head and neck cancer patients?: Objective/Hypothesis To describe clinically relevant between-group differences in MD Anderson Dysphagia Inventory (MDADI) scores among head and neck cancer (HNC) patients. Study Design Retrospective cross-sectional study was conducted in 1,136 HNC patients seen for modified barium swallow (MBS) studies. Methods The MDADI was administered by written questionnaire at the MBS appointment. MD Anderson Dysphagia Inventory global, composite, and subscale scores were calculated. Ancho... περισσότερα »
Detection of human papillomavirus in laryngeal squamous cell carcinoma: Systematic review and meta-analysis
Detection of human papillomavirus in laryngeal squamous cell carcinoma: Systematic review and meta-analysis: Background Recent studies have reported a human papillomavirus (HPV) prevalence of 20% to 30% in laryngeal squamous cell carcinoma (LSCC), although clinical data on HPV involvement remain largely inconsistent, ascribed by some to differences in HPV detection methods or in geographic origin of the studies. Objective To perform a systematic review and formal meta-analysis of the literature reporting on HPV detection in LSCC. Methods Literature was searched from January 1964 unti... περισσότερα »
Both exhaled nitric oxide and blood eosinophil count were associated with mild allergic asthma only in non-smokers
Both exhaled nitric oxide and blood eosinophil count were associated with mild allergic asthma only in non-smokers: *Abstract* Background The fractional exhaled nitric oxide (FENO) and the blood eosinophil count (B-eos) are markers of eosinophilic inflammation used in the diagnosis and management of asthma. The relationships between smoking cigarette and both FENO and B-eos are complex and raise questions about the association between these markers and asthma in smokers. Objective To determine the relationships between both FENO and B-eos on one hand and asthma and atopy on the othe... περισσότερα »
Administration of roflumilast regulates airway inflammation, AHR, and airway remodeling in a model of chronic asthma. The beneficial effects from roflumilast may be related to the SCF/c-kit pathway.
Effect of roflumilast on airway remodeling in a murine model of chronic asthma: Abstract Background Airway remodeling is associated with irreversible, or partially reversible, airflow obstruction and ultimately unresponsiveness to asthma therapies such as corticosteroids. Roflumilast is a selective phosphodiesterase-4 inhibitor that has an anti-inflammatory effect in chronic obstructive pulmonary disease (COPD). Objective To study the effect of roflumilast on airway inflammation and remodeling in a murine model of chronic asthma. Methods BALB/c mice sensitized to ovalbumin (OVA) wer... περισσότερα »
Retrospective complication rate comparison between surgical techniques in paediatric cochlear implantation
Manuscript title: Retrospective complication rate comparison between surgical techniques in paediatric cochlear implantation: Abstract Objective To compare paediatric complication occurrence between the SupraMeatal Approach and the Mastoidectomy with Posterior Tympanotomy Approach for cochlear implantation. Design Retrospective cohort study. Setting Postoperative complications in children younger than 5 years of age, receiving a cochlear implant between 1996 and 2014 at our institution were assessed. Participants 144 patients receiving a cochlear implant (121 by Mastoidectomy with P... περισσότερα »
Elongated Uvula Causing Chronic Cough: Role of the Modified Uvulopalatoplasty Procedure
Elongated Uvula Causing Chronic Cough: Role of the Modified Uvulopalatoplasty Procedure: Objective: A subset of patients previously diagnosed with idiopathic chronic cough were found to have an elongated uvula contacting the laryngeal surface of the epiglottis and inducing a cough reflex. These patients were successfully treated with an in-office modified uvulopalatoplasty procedure (mUPP) at our institution. We aim to further categorize this subset of patients and describe the mUPP that can potentially offer this group of patients cure for their chronic cough. Study Design: Insti... περισσότερα »
Non-invasive measurement of baroreflex during Valsalva maneuver: evaluation of alpha and beta-adrenergic components
Non-invasive measurement of baroreflex during Valsalva maneuver: evaluation of alpha and beta-adrenergic components: Arterial baroreflex plays a pivotal role in maintaining blood pressure (BP), which must constantly adapt in response to both external and internal stressors. Baroreflex sensitivity (BRS) is an important and validated cardiovascular marker, which provides an estimate of the level of hemodynamic adaptation (La Rovere et al. 1998, 2011). BRS consists of vagal (BRSv) and adrenergic (BRSa) components, which relate to beat-to-beat BP responses to heart rate (HR) and total p... περισσότερα »
Effects of rate (0.3-40/s) on simultaneously recorded auditory brainstem, middle and late responses using deconvolution
Effects of rate (0.3-40/s) on simultaneously recorded auditory brainstem, middle and late responses using deconvolution: Auditory evoked potentials (AEPs) are small amplitude electrical potentials generated by overlapping streams of neural activity in response to any sufficiently intense stimulus. For clinical purposes, AEPs are commonly acquired via scalp surface electrodes to assess the function and integrity of the auditory system. The recorded AEP is sensitive to the stimulus content, intensity, presentation rate, subject age, and sex among others. Two types of responses are typ...περισσότερα »
Can a one-day practical lesson in surgical skills encourage medical students to consider a surgical career?
Can a one-day practical lesson in surgical skills encourage medical students to consider a surgical career?: Interest in a surgical career is declining among medical students, and many more need to commit themselves to becoming surgeons to cope with this. We have therefore developed a one-day practical lesson in surgical skills to find out whether a short course such as this can make students more enthusiastic about surgery, and about subsequently pursuing a career in one of its subspecialties. Fifty-four randomly-selected medical students did a one-day practical course in the skill... περισσότερα »
It's not just obstructive sleep apnea
It's not just obstructive sleep apnea: A 61- year-old man with a diagnosis of blastic plasmacytoid dendritic cell neoplasm of the skin presented to our institution for induction chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone. His wife reported snoring for many years, with sudden worsening in the past 3 months and associated with witnessed apneas in the past month. Sleep medicine service was consulted because of an abnormal overnight oximetry study that showed severe oscillatory desaturations suggestive for severe sleep disordered breathing (Figure 1).
Landing Biomechanics and Postural Stability During Adolescence: A Systematic Review with Meta-Analyses
Sex Differences in Landing Biomechanics and Postural Stability During Adolescence: A Systematic Review with Meta-Analyses: Abstract BackgroundThe adolescent ‘growth spurt’ results in rapid growth of the skeletal system. It has been theorised that absence of a concomitant increase in muscular adaptations in female athletes may predispose them to an increased risk of anterior cruciate ligament injuries. ObjectivesTo determine if sex differences exist in landing biomechanics and postural stability of adolescent athletes; with a further objective of determining if such differences a... περισσότερα »
Completeness of cytoreduction is a significant predictor of long-term outcome after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).
Laparoscopy is Safe and Accurate to Evaluate Peritoneal Surface Metastasis Prior to Cytoreductive Surgery: Abstract BackgroundCompleteness of cytoreduction is a significant predictor of long-term outcome after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Imaging has limited sensitivity to identify peritoneal metastases and therefore predict whether complete cytoreduction is possible. We reviewed our experience using laparoscopy to determine candidates for complete cytoreduction and HIPEC. MethodsThis single-center, retrospective study examin...περισσότερα »
Limited Parathyroidectomy in Multiple Endocrine Neoplasia Type 1-Associated Primary Hyperparathyroidism: A Setup for Failure
Limited Parathyroidectomy in Multiple Endocrine Neoplasia Type 1-Associated Primary Hyperparathyroidism: A Setup for Failure: Abstract BackgroundRecently, some surgeons have suggested that minimally invasive parathyroidectomy guided by preoperative localizing studies of patients with multiple endocrine neoplasia type 1 (MEN1)-associated primary hyperparathyroidism (pHPT) provides an acceptable outcome while minimizing the risk of hypoparathyroidism. This study aimed to evaluate the outcome for MEN1 patients who underwent limited parathyroidectomy compared with subtotal parathyroid... περισσότερα »
Complex formation between Tg and Gal-3 through high affinity binding and the sensitivity of the complex to free Tg and Gal-3 can potentially influence their biological functions. Interactions between Tg and Gal-3 might also interfere with their clinical detection, the same way Tg autoantibody (TgAb) is reported to interfere with Tg assays. The data support a model of Gal-3-mediated homeostatic process of Tg.
Glycan-Dependent Mutual and Reversible Sequestration of Two Thyroid Cancer Biomarkers από Ni Fan στο liebertpub1 Thyroid , Vol. 0, No. 0. Author information Ni Fan,1* Melanie L. Talaga,1* Robert K. Brown,1 Ashli L. Fueri,1 Purnima Bandyopadhyay,2 and Tarun K. Dam1,3 1Laboratory of Mechanistic Glycobiology, Department of Chemistry, Michigan Technological University, Houghton, Michigan. 2Department of Biological Sciences, Michigan Technological University, Houghton, Michigan. 3Biotechnology Research Center, Michigan Technological University, Houghton, Michigan. *These authors contribute... περισσότερα »
Radioiodine Therapy for Well-Differentiated Thyroid Cancer : Effects of Thyroid Hormone Withdrawal and Recombinant Human Thyrotropin on Glomerular Filtration Rate
Effects of Thyroid Hormone Withdrawal and Recombinant Human Thyrotropin on Glomerular Filtration Rate During Radioiodine Therapy for Well-Differentiated Thyroid Cancer από George Barberio Coura-Filho στο liebertpub1 Thyroid , Vol. 0, No. 0. Author information George Barberio Coura-Filho,1 Jose Willegaignon,1 Carlos Alberto Buchpiguel, 1,2 and Marcelo Tatit Sapienza1,2 1Nuclear Medicine Service, Instituto do Cancer do Estado de Sao Paulo, University of Sao Paulo, Sao Paulo, Brazil. 2Nuclear Medicine Center, Radiology Institute, University of Sao Paulo General Hospital, Sao Paulo, Brazil...περισσότερα »
Streptococcus pyogenes and Streptococcal Disease
© Kenneth Todar, PhD *Introduction* *Streptococcus pyogenes *(*Group A streptococcus*) is a Gram-positive, nonmotile, nonsporeforming coccus that occurs in chains or in pairs of cells. Individual cells are round-to-ovoid cocci, 0.6-1.0 micrometer in diameter (Figure 1). Streptococci divide in one plane and thus occur in pairs or (especially in liquid media or clinical material) in chains of varying lengths. The metabolism of *S. pyogenes* is fermentative; the organism is a catalase-negative aerotolerant anaerobe (facultative anaerobe), and requires enriched medium containing blood... περισσότερα »
Online Textbook of Bacteriology
* Table of ContentsGeneral BacteriologyOverview of BacteriologyThe Impact of Microbes on the Environment and Human ActivitiesStructure and Function of ProcaryotesNutrition and Growth of BacteriaGrowth of Bacterial PopulationsControl of Microbial GrowthThe Diversity of Procaryotic MetabolismRegulation and Control of Metabolic ActivitiesBacteriophageProcaryotes in the EnvironmentImportant Groups of ProcaryotesBacterial Relationships with AnimalsThe Nature of Host-Parasite InteractionsThe Bacterial Flora of HumansMechanisms ... περισσότερα »
Surgical anatomy of oropharynx and supraglottic larynx for transoral robotic surgery
Surgical anatomy of oropharynx and supraglottic larynx for transoral robotic surgery: Traditional external surgical approaches have been used for the surgical management of the oropharyngeal and laryngeal tumors. Trans-oral robotic surgery allows surgeon to operate oropharyngeal and supraglottic tumors through the mouth with preservation of functions. The surgeons must be knowledgeable about the anatomy of the oral cavity and oropharynx medial to lateral perspective. In this article, we will describe the relevant inside out surgical anatomy and its clinical implications for trans-o... περισσότερα »
Cancer incidence in patients with type 2 diabetes mellitus: a population-based cohort study in Shanghai
Cancer incidence in patients with type 2 diabetes mellitus: a population-based cohort study in Shanghai: Abstract BackgroundType 2 diabetes mellitus (T2DM) has been suggested to increase the risk of cancers. The aim of this study was to investigate the risk of common cancers in Chinese patients with T2DM. MethodsA population-based retrospective cohort study including 36,379 T2DM patients was conducted in Minhang District of Shanghai, China, during 2004 to 2010. All T2DM patients were enrolled from the standardized management system based on local electronic information system. ...περισσότερα »
Histopathologic patterns among achalasia subtypes
Histopathologic patterns among achalasia subtypes: Abstract Background Achalasia has three distinct manometric phenotypes. This study aimed to determine if there were corresponding histopathologic patterns. Methods We retrospectively examined surgical muscularis propria biopsies obtained from 46 patients during laparoscopic esophagomyotomy. Pre-operative (conventional) manometry tracings were reviewed by two expert gastroenterologists who categorized patients into Chicago Classification subtypes. Pathology specimens were graded on degree of neuronal loss, inflammation, fibrosis, and...περισσότερα »
Local release of pioglitazone (a peroxisome proliferator-activated receptor γ agonist) accelerates proliferation and remodeling phases of wound healing
Local release of pioglitazone (a peroxisome proliferator-activated receptor γ agonist) accelerates proliferation and remodeling phases of wound healing: Abstract Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor superfamily known for its anti-inflammatory and macrophage differentiation effects, as well as its ability to promote fat cell differentiation and reduce insulin resistance. Pioglitazone (Pio) is a PPARγ agonist used clinically as an anti-diabetic agent for improving insulin sensitivity in patients with diabetes. The objective of this ... περισσότερα »
Quantifying and correcting for tail vein extravasation in small animal PET scans in cancer research: is there an impact on therapy assessment?
Quantifying and correcting for tail vein extravasation in small animal PET scans in cancer research: is there an impact on therapy assessment?: Abstract BackgroundTail vein injection under short anesthesia is the most commonly used route for administering radiopharmaceuticals. However, the small caliber of the vein in rodents may lead to tracer extravasation and thereby compromise quantitative accuracy of PET. We aimed to evaluate a method for correction of interstitial radiotracer leakage in the context of pre-clinical therapeutic response assessment. MethodsIn two separate st... περισσότερα »
Fascia compared to one-piece composite cartilage-perichondrium grafting for tympanoplasty
Fascia compared to one-piece composite cartilage-perichondrium grafting for tympanoplasty: Objective To evaluate the effectiveness of type 1 tympanoplasty with one-piece composite cartilage-perichondrium (CCP) grafts compared to temporalis fascia (TF) grafts for tympanic membrane (TM) closure and hearing improvement in adult patients with a subtotal TM perforation and chronic otitis media (COM). Data Sources PubMed, Embase, Cochrane Library. Review Methods A systematic search was conducted. Relevance and validity of selected articles were assessed. Studies that scored moderate or hi... περισσότερα »
Urgent resection of a giant left atrial appendage aneurysm and mitral valve replacement in a complex case of Hurler-Scheie syndrome
Hurler-Scheie syndrome is a rare lysosomal storage disease affecting the cardiovascular system. Besides the cardiac manifestations, it presents with complications from abnormal proteoglycan deposition in soft tissues in many locations, resulting in joint contractures, paraplegia, impaired vision, airway narrowing and restrictive lung function, to name a few. There are very few reports of surgical management of valvular heart disease due to mucopolysaccharidosis (MPS). We describe the successful management of a patient with an extremely challenging case of mitral valve stenosis and ...περισσότερα »
Thyroid papillary microcarcinoma: an incidental finding in a patient with coronoid hyperplasia
Description A patient with a history of partial mandibular resection and subsequent reconstruction following a nasopharyngeal carcinoma was referred for evaluation of orofacial pain and restricted mouth opening. Considering the patient's medical history and the diagnostic limitations of standard panoramic X-rays (presence of artefacts, image distortions, etc), further advance imaging (eg, MRI or CT) was considered as a diagnostic and management planning tool, which, due to its accuracy, could enable the identification of the coronoid process volume and morphology, and would also...περισσότερα »
Combined surgical treatment for severe sleep apnoea, to improve BiPAP compliance
Positive airway pressure (PAP) devices are used in the treatment of obstructive sleep apnoea syndrome (OSAS). In cases of PAP failure, many different surgical methods can be used for the treatment. The authors present an unusual case of a patient with Bi-level PAP (BiPAP)-intolerant severe OSAS who was treated with combined surgical methods. A 55-year-old man was treated with BiPAP due to OSAS; he was admitted to the clinic with nose stuffiness, respiratory distress and BiPAP adherence with tolerance and compliance problems. Septal deviation, concha hypertrophy, lateral pharyngeal...περισσότερα »
Chondrosarcoma of the hyoid bone: an atypical site of a sarcoma of the head and the neck
We describe a case of a 73-year-old man with a chondrosarcoma of the hyoid bone. The patient presented with a painless palpable lump in the upper anterior cervical region that had been growing for over 10 months. Fine-needle aspiration cytology suggested pleomorphic adenoma but further imaging investigation with CT revealed an exophytic tumour originating from the body of the hyoid bone with prominent chondroid-like calcifications typical of a chondrosarcoma. Histopathology of the surgical specimen confirmed the diagnosis of a moderately differentiated chondrosarcoma. Chondrosarco... περισσότερα »
The Sonopet for endoscopic posterior split and cartilage graft laryngoplasty
*Sonopet Ultrasonic Aspirator* The Sonopet Ultrasonic Aspirator is a versatile system for precise control of soft tissue while simultaneously allowing fine bone dissection in close proximity to delicate structures. The Sonopet Ultrasonic Aspirator, with its simplistic set up, delivers precise fragmentation, while allowing users to independently control power, suction, and irrigation with one handpiece. Patented LT technology, which is offered on a variety of tips, is a true synergy of control and efficiency. *Features* & Benefits Key advantages include: *Proprietary LT Technology:* Lo... περισσότερα »
Enterobius vermicularis infection of the liver in a patient with colorectal carcinoma with suspected liver metastasis
A 68-year-old man diagnosed with cT3N2 adenocarcinoma of the rectum presented with a synchronous solitary liver metastasis on CT scan. Neoadjuvant chemoradiotherapy was started to downstage the primary tumour. Resection of the rectal tumour followed 3 months after the last radiotherapy session and primary resection of the isolated liver lesion was performed in the intervening period. Histopathological assessment of the liver lesion, however, showed no malignancy, but did reveal a necrotic infection due to *Enterobius vermicularis*. This parasite is frequently found in the intestin...περισσότερα »
A rare case of metachronous penile and urethral metastases from a rectal mucinous adenocarcinoma
Metastatic lesions in the penis are uncommon in patients with prostate or bladder cancer but penile metastatic lesions from rectal tumours are rare with only 65 cases reported in the literature. We describe the case of a 70-year-old man who developed metastatic lesions within his corpus cavernosum 2 years after being diagnosed and treated for a mucinous adenocarcinoma of the rectum and a year after a wedge resection of an isolated lung metastasis. He proceeded with total penectomy and intraoperatively two skip lesions were also found within the wall of his urethra; histological an... περισσότερα »
Think beyond simple pneumonia
Description A 30-year-old African–American man, a truck driver, with a known history of gastro-oesophageal reflux disease, presented with shortness of breath, dry cough and malaise. He was recently hospitalised for community-acquired pneumonia and treated with moxifloxacin, initially intravenously and later orally, after discharge. He felt subjectively better for a few days and then started having more symptoms, which prompted him to return to the emergency department. On examination, he was febrile, tachycardic and tachypnoeic. On auscultation, he had coarse crackles on the rig...περισσότερα »
