Objective Measurements of Ossicular Chain Mobility Using a Palpating Instrument Intraoperatively
Objective Measurements of Ossicular Chain Mobility Using a Palpating Instrument Intraoperatively: [image: image]Background: The judgment of a normal or impaired mobility of middle ear ossicles is based on palpation and depends highly on the surgeon's subjective experience. The aim of this study was to develop and test a palpating instrument recording force and vector and allowing to support the surgeon's subjective impression with objective measurement results. Study Design: Prospective recordings at surgery. Setting: Tertiary referral center. Patients and Methods: A fiberoptic force-... περισσότερα »
Eustachian Tube Mucosal Inflammation Scale Validation Based on Digital Video Images
Eustachian Tube Mucosal Inflammation Scale Validation Based on Digital Video Images: Background: The most common cause for Eustachian tube dilatory dysfunction is mucosal inflammation. The aim of this study was to validate a scale for Eustachian tube mucosal inflammation, based on digital video clips obtained during diagnostic rigid endoscopy. Methods: A previously described four-step scale for grading the degree of inflammation of the mucosa of the Eustachian tube lumen was used for this validation study. A tutorial for use of the scale, including static images and 10 second video c... περισσότερα »
The Efficacy of Color-Mapped Diffusion-Weighted Images Combined With CT in the Diagnosis and Treatment of Cholesteatoma Using Transcanal Endoscopic Ear Surgery
The Efficacy of Color-Mapped Diffusion-Weighted Images Combined With CT in the Diagnosis and Treatment of Cholesteatoma Using Transcanal Endoscopic Ear Surgery: Objective: To assess the efficacy of a color-mapped diffusion-weighted image combined with a computed tomography scan (CMDWI-CT) in preoperatively evaluating the anatomical location of cholesteatomas and determining whether a patient is indicated for transcanal endoscopic ear surgery (TEES) to reduce intraoperative switching to microscopic ear surgery (MES). Study Design: Prospective case study. Setting: A single university h... περισσότερα »
Management of Geniculate Ganglion Hemangiomas: Case Series and Systematic Review of the Literature
Management of Geniculate Ganglion Hemangiomas: Case Series and Systematic Review of the Literature: Objective: To analyze facial nerve (FN) outcomes based on duration of FN palsy and surgical strategy in patients with geniculate ganglion hemangiomas (GGH). Study Design: Case series and systematic review of the literature. Setting: Tertiary care center. Subjects and Methods: All patients undergoing surgical resection of GGH from 1992 to 2014 were studied and a review of the English literature was performed. Results: One hundred twenty unique patients (mean age 41.4 yrs, 44% female) wer...περισσότερα »
Otopathology of Vasculitis in Granulomatosis With Polyangitis
Otopathology of Vasculitis in Granulomatosis With Polyangitis: [image: image]Objective: To describe the temporal bone histopathology of vasculitis in granulomatosis with polyangitis. Background: Granulomatosis with polyangitis is an autoimmune disease that presents as granulomatosis and vasculitis. Otologic findings, including otitis media, hearing loss, vertigo, and facial paralysis are common in this condition. Material and Methods: The temporal bones of four subjects with manifestations of vasculitis attributed to granulomatosis with polyangitis were studied under light microscopy... περισσότερα »
Quality of Life in Patients With Vestibular Schwannomas According to Management Strategy
Quality of Life in Patients With Vestibular Schwannomas According to Management Strategy: [image: image]Objective: This study aimed to evaluate the quality of life of patients treated for unilateral vestibular schwannoma via observation, microsurgery, or gamma knife radiosurgery. Study Design: The study design was retrospective and cross-sectional. Methods: Patients treated for vestibular schwannoma at our institute in 2012–2013 completed a standardized questionnaire (Short Form-36) via telephone to evaluate their quality of life at least 6 months after treatment. Patients were catego...περισσότερα »
Temporal Bone Histopathology in NOG-Symphalangism Spectrum Disorder
Temporal Bone Histopathology in NOG-Symphalangism Spectrum Disorder: [image: image]Objective: To describe the human temporal bone histopathology in NOG-related symphalangism spectrum disorder, a spectrum of congenital stape fixation syndromes caused by mutations in the NOG gene. To discuss implications for clinical management. Patient: A patient with a mutation in the NOG gene. Intervention(s): Removal of temporal bones, postmortem temporal bone computed tomography, histologic processing, and review of temporal bones. Main Outcome Measure(s): Temporal bone histopathology and correlatio... περισσότερα »
The Natural History and Management of Petrous Apex Cholesterol Granulomas
The Natural History and Management of Petrous Apex Cholesterol Granulomas: [image: image]Objective: To evaluate the clinical and radiographic characteristics of cholesterol granulomas of the petrous apex, as well as the outcomes of operative and conservative management. Study Design: Retrospective chart review. Setting: Two independent tertiary academic referral centers. Patients: Adult and pediatric patients with cholesterol granulomas of the petrous apex were identified from the experience of two separate centers. Patients were included after radiographic diagnosis and clinical eval... περισσότερα »
Efficacy and Safety of Transcanal Endoscopic Ear Surgery for Congenital Cholesteatomas: A Preliminary Report
Efficacy and Safety of Transcanal Endoscopic Ear Surgery for Congenital Cholesteatomas: A Preliminary Report: Objective: Transcanal endoscopic ear surgery (TEES) can provide greater visual access during resection of middle ear disease than the operating microscope. The purpose of this study was to determine the safety and efficacy of TEES when used for the management of congenital cholesteatoma (CC) in children. Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Twelve children with CC confined to the middle ear underwent TEES. Seven children were Po...περισσότερα »
Histopathologic Findings in Peripheral Vestibular System From Patients With Systemic Lupus Erythematosus: A Human Temporal Bone Study
Histopathologic Findings in Peripheral Vestibular System From Patients With Systemic Lupus Erythematosus: A Human Temporal Bone Study: [image: image]Hypothesis: We hypothesized that a pathologic condition exists in vestibular hair cells in human temporal bones from patients with systemic lupus erythematosus (SLE). Background: A significant association between sensorineural hearing loss and autoimmune disease has been reported. Patients with SLE also frequently have vestibular symptoms whose pathophysiologic mechanism is unclear. Methods: We examined 15 temporal bone samples from 8 pat... περισσότερα »
Speech Perception of Elderly Cochlear Implant Users Under Different Noise Conditions
Speech Perception of Elderly Cochlear Implant Users Under Different Noise Conditions: Objective: The primary objective of this study was the comparison of younger and older (>75 yr) CI recipients’ performance for speech perception in quiet and in competing continuous and fluctuating noise. Study Design: Prospective, comparative clinical study. Setting: University hospital. Patients: Fifty patients, 25 older and 25 younger than 75 years, with a postlingually acquired profound hearing loss who received a cochlear implant at least 1 year before study start were enrolled. Interventions: C... περισσότερα »
Utility of an Abbreviated Dizziness Questionnaire to Differentiate Between Causes of Vertigo and Guide Appropriate Referral: A Multicenter Prospective Blinded Study
Utility of an Abbreviated Dizziness Questionnaire to Differentiate Between Causes of Vertigo and Guide Appropriate Referral: A Multicenter Prospective Blinded Study: [image: image] Objective: Test performance of a focused dizziness questionnaire's ability to discriminate between peripheral and nonperipheral causes of vertigo. Study Design: Prospective multicenter. Setting: Four academic centers with experienced balance specialists. Patients: New dizzy patients. Interventions: A 32-question survey was given to participants. Balance specialists were blinded and a diagnosis was establish... περισσότερα »
The Impact of Postmeningitic Labyrinthitis Ossificans on Speech Performance After Pediatric Cochlear Implantation
The Impact of Postmeningitic Labyrinthitis Ossificans on Speech Performance After Pediatric Cochlear Implantation: [image: image] Objective: 1) To characterize pediatric cochlear implant performance in patients with hearing loss secondary to bacterial meningitis. 2) To evaluate performance differences in patients with and without labyrinthitis ossificans (LO). Study Design: Retrospective case review. Setting: A large university-based multidisciplinary cochlear implant program. Patients: Forty-nine patients with hearing loss from bacterial meningitis who received cochlear implants fr... περισσότερα »
HASTE Diffusion-Weighted Magnetic Resonance Imaging of Middle Ear Teratoma
HASTE Diffusion-Weighted Magnetic Resonance Imaging of Middle Ear Teratoma: [image: image]
Successful Hearing Preservation After Reimplantation of a Failed Hybrid Cochlear Implant
Successful Hearing Preservation After Reimplantation of a Failed Hybrid Cochlear Implant: [image: image]Objective: Superficial siderosis (SS) of the CNS is associated with cerebellar ataxia, sensorineural hearing loss, and pyramidal symptoms, which result from iron depositions on CNS surfaces. SS can produce bilateral vestibulopathy because the vestibulo-cochlear nerve is particularly vulnerable. To our knowledge, however, vestibular dysfunction in SS has not been reported thoroughly in the literature. Here, we describe a case of bilateral vestibulopathy, documented quantitatively b...περισσότερα »
Electro-Mechanical Stimulation of the Cochlea by Vibrating Cochlear Implant Electrodes
Electro-Mechanical Stimulation of the Cochlea by Vibrating Cochlear Implant Electrodes: [image: image] Introduction: Electro-acoustic stimulation (EAS) of the cochlea uses the preserved residual low-frequency hearing for acoustic stimulation in combination with electrical stimulation. The acoustic low-frequency component is amplified and high-frequency hearing is enhanced by a cochlear implant (CI). In this work, the feasibility of EAS by the floating mass transducers (FMTs) firmly attached to the implanted electrode was investigated and the achieved stapes displacement was compare... περισσότερα »
Altered Contralateral Auditory Cortical Morphology in Unilateral Sudden Sensorineural Hearing Loss
Altered Contralateral Auditory Cortical Morphology in Unilateral Sudden Sensorineural Hearing Loss: [image: image]Objective: To investigate the cerebral gray matter volume alterations in unilateral sudden sensorineural hearing loss patients within the acute period by the voxel-based morphometry method, and to determine if hearing impairment is associated with regional gray matter alterations in unilateral sudden sensorineural hearing loss patients. Study Design: Prospective case study. Setting: Tertiary class A teaching hospital. Patients: Thirty-nine patients with left-side unilatera...περισσότερα »
Incidence of Retrocochlear Pathology Found on MRI in Patients With Non-Pulsatile Tinnitus
Incidence of Retrocochlear Pathology Found on MRI in Patients With Non-Pulsatile Tinnitus: [image: image]Objective: To identify the incidence of retrocochlear pathology on MRI in patients with non-pulsatile tinnitus. Study Design: Retrospective review. Setting: Tertiary referral center. Patients: Adults with MRIs performed between March 1, 2008 and February 1, 2014 for non-pulsatile tinnitus with or without hearing loss. Intervention: MRI. Main Outcome Measure: Incidence of retrocochlear pathology. Results: Of the 218 patients who met inclusion criteria, 198 (91.3%) had unremarkable MRI... περισσότερα »
Histopathology of the Human Inner Ear in a Patient With Sensorineural Hearing Loss Caused by a Variant in DFNA5
Histopathology of the Human Inner Ear in a Patient With Sensorineural Hearing Loss Caused by a Variant in DFNA5: [image: image] Hypothesis: Describe the histopathology of the inner ear in a patient with hearing loss caused by a pathogenic variant of the DFNA5 gene. Background: Variants in DFNA5 have been described as causing an autosomal dominant nonsyndromic sensorineural hearing loss. To date, there has been no description of the histopathology of the inner ear in humans with hearing loss because of pathogenic variants in DFNA5. Methods: Temporal bone histopathology by light micros... περισσότερα »
Canal Paresis in Benign Paroxysmal Positional Vertigo Secondary to Sudden Sensorineural Hearing Loss
Canal Paresis in Benign Paroxysmal Positional Vertigo Secondary to Sudden Sensorineural Hearing Loss: [image: image]Objectives: To review the clinical features of benign paroxysmal positional vertigo (BPPV) secondary to sudden sensorineural hearing loss (SNHL) and to analyze the correlation between canal paresis and the effectiveness of canalith repositioning procedures (CRPs) for the treatment. Design: Study case series with chart review. Setting: Academic university hospital. Patients: We retrospectively reviewed 277 patients with BPPV. For sudden SNHL with a recent vertigo, patient... περισσότερα »
Evaluation of Magnetic Resonance Imaging Diagnostic Approaches for Vestibular Schwannoma Based on Hearing Threshold Differences Between Ears: Added Value of Auditory Brainstem Responses
Evaluation of Magnetic Resonance Imaging Diagnostic Approaches for Vestibular Schwannoma Based on Hearing Threshold Differences Between Ears: Added Value of Auditory Brainstem Responses: [image: image]Objective: This study investigates the most appropriate audiometric criterion in deciding which patients with asymmetric hearing loss should be referred to MRI to exclude a lesion in the cerebellopontine angle (CPA). Careful selection of patients could improve resource utilization while preventing unnecessary investigations with accompanying burden and costs. Study Design: Retrospective... περισσότερα »
Hearing Loss Caused by Surgical Antiseptic in the Setting of an Unknown Tympanic Perforation
Hearing Loss Caused by Surgical Antiseptic in the Setting of an Unknown Tympanic Perforation
Efficacy of Concomitant Intratympanic Steroid Injection for Sudden Deafness According to Initial Hearing Loss
Efficacy of Concomitant Intratympanic Steroid Injection for Sudden Deafness According to Initial Hearing Loss: [image: image]Objectives/Hypothesis: We identified the efficacy and appropriate target group for intratympanic steroid injections (ITS) in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Study Design: Retrospective case-control study. Methods: Fifty-five ears treated with concomitant ITS and systemic steroids and 165 ears without ITS treatment were identified. Each case had three controls matched according to the age, sex, and the presence of vertigo. Pa... περισσότερα »
Dexamethasone Protects Against Radiation-induced Loss of Auditory Hair Cells In Vitro
Dexamethasone Protects Against Radiation-induced Loss of Auditory Hair Cells In Vitro: [image: image] Hypothesis: Dexamethasone (DXM) protects against radiation-induced loss of auditory hair cells (HCs) in rat organ of Corti (OC) explants by reducing levels of oxidative stress and apoptosis. Background: Radiation-induced sensorineural hearing loss (HL) is progressive, dose-dependent, and irreversible. Currently, there are no preventative therapeutic modalities for radiation-induced HL. DXM is a synthetic steroid that can potentially target many of the pathways involved in radiation... περισσότερα »
Outcomes in Stapedotomy Surgery: The Learning Curve Redefined
Outcomes in Stapedotomy Surgery: The Learning Curve Redefined: [image: image]Objective: The aim of this study is to determine if the cumulative summation test for the learning curve (LC-CUSUM) and the cumulative summation graph (CUSUM) can be used to demonstrate landmark points of competence and maintenance of proficiency in stapes surgery over a continuous time period. Study Design: Retrospective review from January 1999 until August 2014. Setting: Tertiary referral hospital. Patients: All adult patients with confirmed otosclerosis. Intervention(s): Two-hundred and four primary and re... περισσότερα »
Health Utility Improves After Surgery for Superior Canal Dehiscence Syndrome
Health Utility Improves After Surgery for Superior Canal Dehiscence Syndrome: Objective: Health utility value (HUV) is an outcome measure used to calculate quality adjusted life years (QALYs) and to determine cost-effectiveness of medical treatments. Herein, we measure HUV in patients with superior canal dehiscence syndrome (SCDS) before and after surgical repair. Health utility values of patients with SCDS are compared to normative data of the general United States population. Study Design: Retrospective review of prospectively collected data. Patients: Adult patients with SCDS. Sett... περισσότερα »
Treatment Effectiveness for Symptoms of Patulous Eustachian Tube: A Systematic Review
Treatment Effectiveness for Symptoms of Patulous Eustachian Tube: A Systematic Review: [image: image]Objectives: To determine the effectiveness of currently available medical and surgical interventions for treating symptoms of Patulous Eustachian Tube (PET). Data Sources: A comprehensive search of MEDLINE (January 1948 to July 8, 2015), EMBASE (January 1974 to July 8, 2015), gray literature, hand searches, and cross-reference checking. Study Selection: Original published reports evaluating an intervention to treat the symptoms of patulous eustachian tube in patients 18 years and olde... περισσότερα »
Impact of Elevation of Temporal Lobe During Middle Fossa Acoustic Neuroma Surgery on Contralateral Speech Discrimination
Impact of Elevation of Temporal Lobe During Middle Fossa Acoustic Neuroma Surgery on Contralateral Speech Discrimination: [image: image]Aim: For middle fossa acoustic neuroma approach, retractors are needed to elevate the temporal lobe to be able to access the internal auditory meatus. The temporal lobe hosts the primary and secondary auditory fields. The question arises regarding whether this elevation affects the functionality of the auditory cortex. Material and Methods: In patients, who underwent acoustic neuroma surgery, contralateral speech discrimination was tested pre- and po... περισσότερα »
Sensitivity study of prompt gamma imaging of scanned beam proton therapy in heterogeneous anatomies
[image: gr1.sml] To investigate the use of a fast analytical prediction algorithm in the evaluation of the accuracy in Bragg peak position estimation using prompt gamma imaging in realistic anatomies. from Rathiotherapy via ola Kala on Inoreader http://ift.tt/1PPZRuG via IFTTT
Gadoxetate for direct tumor therapy and tracking with real-time MRI-guided stereotactic body radiation therapy of the liver
SBRT is increasingly utilized in liver tumor treatment. MRI-guided RT allows for real-time MRI tracking during therapy. Liver tumors are often poorly visualized and most contrast agents are transient. Gadoxetate may allow for sustained tumor visualization. Here, we report on the first use of gadoxetate during real-time MRI-guided SBRT. from Rathiotherapy via ola Kala on Inoreader http://ift.tt/1PPZPmJ via IFTTT
Canal Paresis in Benign Paroxysmal Positional Vertigo Secondary to Sudden Sensorineural Hearing Loss
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Canal Paresis in Benign Paroxysmal Positional Vertigo Secondary to Sudden Sensorineural Hearing Loss: [image: image]Objectives: To review the clinical features of benign paroxysmal positional vertigo (BPPV) secondary to sudden sensorineural hearing loss (SNHL) and to analyze the correlation between canal paresis and the effectiveness of canalith repositioning procedures (CRPs) for the treatment. Design: Study case series with chart review. Setting: Academic university hospital. Patients: We retrospectively reviewed 277 patients with BPPV. For sudden SNHL with a recent vertigo, patient... περισσότερα »
Evaluation of Magnetic Resonance Imaging Diagnostic Approaches for Vestibular Schwannoma Based on Hearing Threshold Differences Between Ears: Added Value of Auditory Brainstem Responses
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Evaluation of Magnetic Resonance Imaging Diagnostic Approaches for Vestibular Schwannoma Based on Hearing Threshold Differences Between Ears: Added Value of Auditory Brainstem Responses: [image: image]Objective: This study investigates the most appropriate audiometric criterion in deciding which patients with asymmetric hearing loss should be referred to MRI to exclude a lesion in the cerebellopontine angle (CPA). Careful selection of patients could improve resource utilization while preventing unnecessary investigations with accompanying burden and costs. Study Design: Retrospective... περισσότερα »
Prenatal stress and early-life exposure to fluoxetine have enduring effects on anxiety and hippocampal BDNF gene expression in adult male offspring
ABSTRACT With the growing use of selective serotonin reuptake inhibitor medications (SSRIs) for the treatment of depression during the perinatal period, questions have been raised about the longterm impact of these medications on development. We aimed to investigate how developmental SSRI exposure may alter affect-related behaviors and associated molecular processes in offspring using a rodent model of maternal stress and depression. For this purpose, prenatally stressed or non-stressed male offspring were exposed to fluoxetine (5 mg/kg/day) or vehicle, via lactation, until weaning...περισσότερα »
The distribution of probability values in medical abstracts: an observational study
Background: A relatively high incidence of p values immediately below 0.05 (such as 0.047 or 0.04) compared to p values immediately above 0.05 (such as 0.051 or 0.06) has been noticed anecdotally in published medical abstracts. If p values immediately below 0.05 are over-represented, such a distribution may reflect the true underlying distribution of p values or may be due to error (a false distribution). If due to error, a consistent over-representation of p values immediately below 0.05 would be a systematic error due either to publication bias or (overt or inadvertent) bias wit... περισσότερα »
Hearing Loss Caused by Surgical Antiseptic in the Setting of an Unknown Tympanic Perforation
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Hearing Loss Caused by Surgical Antiseptic in the Setting of an Unknown Tympanic Perforation:
β cell membrane remodelling and procoagulant events occur in inflammation-driven insulin impairment: a GLP-1 receptor dependent and independent control
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Abstract Inflammation and hyperglycaemia are associated with a prothrombotic state. Cell-derived microparticles (MPs) are the conveyors of active procoagulant tissue factor (TF) and circulate at high concentration in diabetic patients. Liraglutide, a glucagon-like peptide (GLP)-1 analogue, is known to promote insulin secretion and β-cell preservation. In this *in vitro* study, we examined the link between insulin impairment, procoagulant activity and plasma membrane remodelling, under inflammatory conditions. Rin-m5f β-cell function, TF activity mediated by MPs and their modulation... περισσότερα »
An epidemiological investigation to reconstruct a probable human immunodeficiency virus -1 transmission network: a case report
Background: Recently published studies have highlighted the importance of phylogenetic and phylodynamic analyses in supporting epidemiological investigations to reconstruct the transmission network of human immunodeficiency virus. Here, we report a case of sexual transmission of human immunodeficiency virus type 1 between a man and a woman that marks once more the importance of a tightened collaboration between phylogeny and epidemiology.Case presentationWe describe a case of human immunodeficiency virus type 1 subtype B transmission in a stable Caucasian heterosexual couple. The ...περισσότερα »
Systematic Review of Treatments for Autoimmune Inner Ear Disease
Systematic Review of Treatments for Autoimmune Inner Ear Disease: Objective: To systematically evaluate the evidence for treatment of autoimmune inner ear disease (AIED). Data Sources: Medline/EMBASE, Cochrane Review. Study Selection: Studies reviewed were English language original articles reporting outcome data for subjects with AIED undergoing any treatment other than oral steroids alone with particular emphasis on prospectively collected data. Data Extraction: The full text of articles meeting selection criteria was reviewed for subject inclusion criteria, number of subjects, trea... περισσότερα »
Tinnitus From Loud Explosion
Tinnitus From Loud Explosion: One of the most common causes of tinnitus is exposure to loud sounds. In many cases, the sounds are heard on a recurring basis. For example, musicians often develop tinnitus due to their exposure to loud music, and construction workers, pilots and others may also hear loud sounds regularly while on the job. However, even a single loud sound can be enough to cause tinnitus in some people. For example, you can develop tinnitus from loud explosion sounds. These include bombs exploding and gunshots as well as various other loud sounds in your environment. ...περισσότερα »
Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections
Sphingolipids as Regulators of the Phagocytic Response to Fungal Infections: Fungal infections pose a significant risk for the increasing population of individuals who are immunocompromised. Phagocytes play an important role in immune defense against fungal pathogens, but the interactions between host and fungi are still not well understood. Sphingolipids have been shown to play an important role in many cell functions, including the function of phagocytes. In this review, we discuss major findings that relate to the importance of sphingolipids in macrophage and neutrophil function a... περισσότερα »
Development of an improved bone washing and demineralisation process to produce large demineralised human cancellous bone sponges
Development of an improved bone washing and demineralisation process to produce large demineralised human cancellous bone sponges: AbstractShaped demineralised bone matrices (DBM) made from cancellous bone have important uses in orthopaedic and dental procedures, where the properties of the material allow its insertion into confined defects, therefore acting as a void filler and scaffold onto which new bone can form. The sponges are often small in size, <1.0 cm3. In this study, we report on an improved bone washing and demineralisation process that allows production of larger DBM s...περισσότερα »
Impact of expiratory strength training in amyotrophic lateral sclerosis.
Impact of expiratory strength training in amyotrophic lateral sclerosis.: *Impact of expiratory strength training in amyotrophic lateral sclerosis.* Muscle Nerve. 2015 Nov 24; Authors: Plowman EK, Watts SA, Tabor L, Robison R, Gaziano J, Domer AS, Richter J, Vu T, Gooch C Abstract INTRODUCTION: We evaluated the feasibility and impact of Expiratory Muscle Strength Training (EMST) on respiratory and bulbar function in persons with amyotrophic lateral sclerosis (ALS). METHODS: 25 ALS patients participated in this delayed intervention open-label clinical trial. Following a lead-in pe... περισσότερα »
A Rare Cause of Dysphagia--Kommerell's Diverticulum.
A Rare Cause of Dysphagia--Kommerell's Diverticulum.: *A Rare Cause of Dysphagia--Kommerell's Diverticulum.* J Assoc Physicians India. 2015 Jan;63(1):59-62 Authors: Parikh P, Nasa M, Patil S, Patel J, Bhate P, Sawant P Abstract A right-sided aortic arch with an aneurysm of the aberrant subclavian artery is a rare disease. We report a case of Kommerell's diverticulum of an aberrant left subclavian artery in a patient with a right-sided aortic arch with associated ventricular septal defect. Fewer than 50 cases have been reported in literature so far. Our patient presented with short... περισσότερα »
Rare medical manifestations of severe restricting and purging: "Zebras," missed diagnoses, and best practices.
Rare medical manifestations of severe restricting and purging: "Zebras," missed diagnoses, and best practices.: *Rare medical manifestations of severe restricting and purging: "Zebras," missed diagnoses, and best practices.* Int J Eat Disord. 2015 Nov 23; Authors: Gaudiani JL, Mehler PS Abstract OBJECTIVE: Medical problems that arise due to severe restricting and/or purging may be misdiagnosed or suboptimally treated, from outpatient clinics to top medical hospitals. A symptom may be presumed to be a psychological manifestation of the eating disorder and inappropriately dismisse... περισσότερα »
Prospective Multicenter Assessment of Early Complication Rates Associated With Adult Cervical Deformity Surgery in 78 Patients.
Prospective Multicenter Assessment of Early Complication Rates Associated With Adult Cervical Deformity Surgery in 78 Patients.: *Prospective Multicenter Assessment of Early Complication Rates Associated With Adult Cervical Deformity Surgery in 78 Patients.* Neurosurgery. 2015 Nov 19; Authors: Smith JS, Ramchandran S, Lafage V, Shaffrey CI, Ailon T, Klineberg E, Protopsaltis T, Schwab FJ, OʼBrien M, Hostin R, Gupta M, Mundis G, Hart R, Kim HJ, Passias P, Scheer JK, Deviren V, Burton DC, Eastlack R, Bess S, Albert TJ, Riew KD, Ames CP, International Spine Study Group Abstract BACK... περισσότερα »
Dysphagia: prevalence, management and the community nurse.
Dysphagia: prevalence, management and the community nurse.: *Dysphagia: prevalence, management and the community nurse.* Community Pract. 2015 Oct;88(10):32-5 Authors: Smithard DG Abstract Swallowing problems are common and may occur in non neurological conditions. Swallowing problems are often insidious and ignored in older people; dysphagia should be recognized as a geriatric syndrome. It is important to identify this to ensure appropriate intervention and management is put into place. A Community Nurse is ideally placed to do this. PMID: 26596131 [PubMed - in process]
Finding the red flags: Swallowing difficulties after cardiac surgery in patients with prolonged intubation.
Finding the red flags: Swallowing difficulties after cardiac surgery in patients with prolonged intubation.: *Finding the red flags: Swallowing difficulties after cardiac surgery in patients with prolonged intubation.* J Crit Care. 2015 Oct 20; Authors: Daly E, Miles A, Scott S, Gillham M Abstract PURPOSE: This retrospective audit set out to identify referral rates, swallowing characteristics, and risk factors for dysphagia and silent aspiration in at-risk patients after cardiac surgery. Dysphagia and silent aspiration are associated with poorer outcomes post cardiac surgery. ME... περισσότερα »
The effects of bolus volume and texture on pharyngeal pressure events using high resolution manometry and its comparison with videofluoroscopic swallowing study.
The effects of bolus volume and texture on pharyngeal pressure events using high resolution manometry and its comparison with videofluoroscopic swallowing study.: *The effects of bolus volume and texture on pharyngeal pressure events using high resolution manometry and its comparison with videofluoroscopic swallowing study.* J Neurogastroenterol Motil. 2015 Nov 24; Authors: Ryu JS, Park D, Oh Y, Lee ST, Kang JY Abstract Background/Aims: The purpose of this study was to develop new parameters of high-resolution manometry (HRM) and to applicate those to quantify the effect of bolu... περισσότερα »
Dysphagia Rehabilitation in Japan.
Dysphagia Rehabilitation in Japan.: *Dysphagia Rehabilitation in Japan.* J Nutr Sci Vitaminol (Tokyo). 2015;61(Supplement):S72-S73 Authors: Inoue M Abstract In Japan, one of the most common causes of death in elderly people is aspiration pneumonia. Maintenance of oral hygiene and feeding functions are important elements, especially in patients with dysphagia caused by stroke, neurological diseases, and after operations on the head and neck cancer, as well as in the elderly to prevent aspiration pneumonia. It should also be noted that not only oral health care and physical therapy... περισσότερα »
Large-Cell Neuroendocrine Carcinoma of the Esophagus: A Case from Saudi Arabia.
Large-Cell Neuroendocrine Carcinoma of the Esophagus: A Case from Saudi Arabia.: *Large-Cell Neuroendocrine Carcinoma of the Esophagus: A Case from Saudi Arabia.* Case Rep Gastroenterol. 2015 Sep-Dec;9(3):327-334 Authors: Kuriry H, Swied AM Abstract Neuroendocrine carcinomas of the esophagus are very rare, and the majority are high grade (poorly differentiated). They occur most frequently in males in their sixth and seventh decades of life. There have been no concrete data published on clinical features or on prognosis. We report a case of large-cell neuroendocrine carcinoma of ...περισσότερα »
Capsule Endoscope Aspiration after Repeated Attempts for Ingesting a Patency Capsule.
Capsule Endoscope Aspiration after Repeated Attempts for Ingesting a Patency Capsule.: *Capsule Endoscope Aspiration after Repeated Attempts for Ingesting a Patency Capsule.* Case Rep Gastroenterol. 2015 Sep-Dec;9(3):347-352 Authors: Mannami T, Ikeda G, Seno S, Sonobe H, Fujiwara N, Komoda M, Edahiro S, Ohtawa Y, Fujimoto Y, Sato N, Kambara T, Waku T Abstract Capsule endoscope aspiration into the respiratory tract is a rare complication of capsule endoscopy. Despite the potential seriousness of this complication, no accepted methods exist to accurately predict and therefore prev...περισσότερα »
Brain Herniation in Neurofibromatosis with Dysplasia of Occipital Bone and Posterior Skull Base.
Brain Herniation in Neurofibromatosis with Dysplasia of Occipital Bone and Posterior Skull Base.: *Brain Herniation in Neurofibromatosis with Dysplasia of Occipital Bone and Posterior Skull Base.* Case Rep Neurol Med. 2015;2015:816079 Authors: Rangarajan V, Mahore A, Patil M, Sathe P, Kaswa A, Gore S, Dharurkar P, Kawale J Abstract A 22-year-old female, a known case of neurofibromatosis 1 (NF1), presented with a congenital swelling in the left occipital region. She had developed recent onset dysphagia and localized occipital headache. Neuroradiology revealed a left occipital men...περισσότερα »
Eosinophilic esophagitis: From pathophysiology to treatment.
Eosinophilic esophagitis: From pathophysiology to treatment.: *Eosinophilic esophagitis: From pathophysiology to treatment.* World J Gastrointest Pathophysiol. 2015 Nov 15;6(4):150-158 Authors: D'Alessandro A, Esposito D, Pesce M, Cuomo R, De Palma GD, Sarnelli G Abstract Eosinophilic esophagitis (EoE) is a chronic immune disease, characterized by a dense eosinophilic infiltrate in the esophagus, leading to bolus impaction and reflux-like symptoms. Traditionally considered a pediatric disease, the number of adult patients with EoE is continuously increasing, with a relatively hig...περισσότερα »
Effect of dynamic seeding methods on the distribution of fibroblasts within human acellular dermis
Effect of dynamic seeding methods on the distribution of fibroblasts within human acellular dermis: AbstractThe purpose of this investigation was to compare different dynamic cell seeding methods regarding their seeding efficiency, homogeneity, infiltration depth and proliferation within a human acellular dermis. In addition, the growth behaviour was observed during a 12-day static in vitro culture. The dynamic methods included orbital-shaker seeding and the use of a plate centrifuge with different rotational speeds, combinations of low-pressure for matrix degassing and centrifugal... περισσότερα »
Review of the cellular and biological principles of Distraction Osteogenesis: An in vivo bioreactor tissue-engineering model
The surgical technique of distraction osteogenesis is widely used in plastic and orthopaedic surgery. During the process mechanical force is applied to fractured bone to enhance the regenerative processes and induce new bone formation.Although there is an abundance of literature on the clinical process of distraction osteogenesis, there is a distinct lack of focus on the underlying biological principles governing this process. Distraction osteogenesis obeys the basic premises of tissue engineering. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1YvtLpA via I...περισσότερα »
Correcting epicanthal folds by using asymmetric Z-plasty with a two curve design
The epicanthus is the oblique or vertical skin fold located medial to the medial canthus. A significant epicanthal fold can partially cover the caruncula lacrimalis and extend the space between the inner canthi. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1Ic6Mfp via IFTTT
Impact of Increasing Age on Breast Reduction Surgery: A Single Center Analysis
Women with hypertrophic breasts suffer for physical and psychological reasons. Breast reduction surgery is a safe procedure that can effectively improve symptoms and quality of life. As most studies have been performed in younger women, little is known about complications and long-term patient satisfaction in elderly women. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1Ic6Mfl via IFTTT
Living donor bone banking: processing and discarding—from procurement to therapeutic use
Living donor bone banking: processing and discarding—from procurement to therapeutic use: AbstractSkeletal muscle and osteoarticular tissue banks are responsible to procure, process, store and distribute tissues, from living and cadaveric donors. The procedures involve the application of protocols covering all aspects of the banking, ensuring the best tissue quality and maximum safety for the recipient. An analysis on the causes of bone tissue discarded by Biotar Tissue Bank between January 2005 and December 2012 was carried. Bone tissue was obtained from both hip and knee replacem...περισσότερα »
Cerebellar EBV-associated diffuse large B cell lymphoma following angioimmunoblastic T cell lymphoma
Cerebellar EBV-associated diffuse large B cell lymphoma following angioimmunoblastic T cell lymphoma: AbstractEpstein-Barr virus (EBV)-associated B cell lymphoproliferative disorders may be seen in patients with angioimmunoblastic T cell lymphoma (AITL). Although both nodal and extranodal sites of involvement have been described, central nervous system involvement by B cell lymphoma following AITL has not previously been documented. We report a first example of such unusual presentation, in which an 80-year-old man developed diffuse large B cell lymphoma (DLBCL) in the cerebellum 4...περισσότερα »
Structural studies of novel glycoconjugates from polymerized allergens (allergoids) and mannans as allergy vaccines
Structural studies of novel glycoconjugates from polymerized allergens (allergoids) and mannans as allergy vaccines: AbstractImmunotherapy for treating IgE-mediated allergies requires high doses of the corresponding allergen. This may result in undesired side effects and, to avoid them, hypoallergenic allergens (allergoids) polymerized with glutaraldehyde are commonly used. Targeting allergoids to dendritic cells to enhance cell uptake may result in a more effective immunotherapy. Allergoids coupled to yeast mannan, as source of polymannoses, would be suitable for this purpose, sin... περισσότερα »
Proliferative verrucous leukoplakia
Clinicopathologic diagnostic criteria of an enigmatic entity: Proliferative verrucous leukoplakia: *Ramnarayan Belur Krishna Prasad, Prathima Mallappa Maligi, Smitha Thimappa, Shashi Ram* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):432-436 Proliferative verrucous leukoplakia (PVL) is a rare, unique type of oral leukoplakia, which is enigmatic in etiology and behaves in a far more aggressive fashion than other forms of leukoplakia. Diagnosis is often late with the disease in an advanced stage when it is especially refractory to treatment. There are no defi... περισσότερα »
Oral hemangioma or vascular malformation: Different entities!
Oral hemangioma or vascular malformation: Different entities!: *Ujwala Rohan Newadkar* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):497-499 The confusing and often misleading terminology used to define oral vascular tumescences along with the generic use of the term hemangioma has led to inappropriate grouping of a number of entities that are known to be biologically distinct. In many cases, the differential diagnosis between hemangioma and vascular malformation cannot be made on the basis of routine analysis. Hemangiomas were differentiated from vascular ...περισσότερα »
Lipoid proteinosis with oral manifestation.Urbach–Wiethe disease
Lipoid proteinosis with oral manifestation in a geriatric patient: A unique case report: *Jayachandran Sadaksharam, Bakyalakshmi Karthikeyan, Sureshkumar Mahalingam, Sarala Kessavalou* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):428-431 Lipoid proteinosis is a very rare, autosomal recessive disorder, characterized by hoarseness of voice, skin scarring, beaded papules along the eyelid margins, and an inability to protrude the enlarged tongue. Infiltration of hyaline material to various organs is found to be responsible for the various manifestations of thi... περισσότερα »
Non-exposed variant of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with a plasmacytoma: A rare case report
Non-exposed variant of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with a plasmacytoma: A rare case report: *Arvind Muthukrishnan, Gowri Shankar Sekar* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):423-427 Bisphoshonate-related osteonecrosis of the jaw (BRONJ) is an avascular osteo-chemonecrosis of the jaw which results after administration of the group of drugs called as bisphosphonates. Bisphosphonates are given to prevent bone resorption in osteolytic diseases such as Paget's, osteoporosis, osteogenic carcinoma, and other carcinomas where the...περισσότερα »
Oral health presentations and considerations in gastrointestinal diseases
Oral health presentations and considerations in gastrointestinal diseases: *Christeffi Mabel Rolands* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):412-415 Lesions of the gastrointestinal tract (GIT) run the gamut from the merely annoying heartburn that has affected many a partakers of a large and spicy meal to the highly lethal cancers. Distressing to the physician is that all disorders of the esophagus tend to produce similar symptoms, namely heartburn, dysphagia, pain, and/or hematemesis. The GIT plays a prominent part in the immune system. The pH (rangi... περισσότερα »
Acquired partial lipodystrophy
Acquired partial lipodystrophy: An atypical presentation with therapeutic challenge: *Komali Garlapati, Anusha Rembers, Balaji Dara, Mamatha Boringi* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):464-467 Lipodystrophy is regarded as a functional disturbance of the hypothalamus. Typically, face is the first part to be affected, and its aspect in an advanced case is characteristic: hollowed temples, prominent zygomatic bones, and sunken cheeks. When the patient smiles, numerous wrinkles appear in the cheeks, giving the appearance of premature senility. Here is... περισσότερα »
Intraoral hydatid cyst: A rare case report
Intraoral hydatid cyst: A rare case report: *Ravi Kiran Alaparthi, Samatha Yelamanchili, Purnachandrarao Naik Nunsavathu, Udaya Sode* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):457-460 "Hydatid" is a Greek word which means "a drop of water." Hydatid cysts occur in hydatid disease or echinococcosis, which is one of the most geographically prevalent zoonosis. This zoonotic infection in humans is mainly caused by infection by the larval stage of the dog tapeworm Echinococcus granulosus. This tapeworm infestation is widespread in sheep, goats, cattle, and do...περισσότερα »
Sexual dimorphism in permanent maxillary and mandibular canines and intermolar arch width: Endemic study
Sexual dimorphism in permanent maxillary and mandibular canines and intermolar arch width: Endemic study: *Mohammed Asif Syed, Bhargav Selarka, Vivek Tarsariya* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):405-411 Aims and Objectives: The purpose of this study was to investigate whether dimorphism of permanent mandibular and maxillary canine teeth as well as intercanine and intermolar distance plays a role in establishing sex identity. Materials and Methods: Four hundred volunteers comprising 200 males and 200 females, with age ranging from 18 to 50 years,...περισσότερα »
Personal identification and sex determination using cheiloscopy
Personal identification and sex determination using cheiloscopy: *Ravindra Naik Gugulothu, Ravi Kiran Alaparthi, Kotya Naik Maloth, Sunitha Kesidi, Vinay Kundoor, Mallika Mahalakshmi Palutla* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):399-404 Introduction: Identification of an individual is a prerequisite for certification of death and for personal, social, and legal reasons. The study of lip prints (cheiloscopy) was thought of as a method of identification of a person. It is safe to assume that cheiloscopy, in its present stage of development, has becom... περισσότερα »
Palatal Rugoscopy: A new era for forensic identification
Palatal Rugoscopy: A new era for forensic identification: *Namrata Harchandani, Swati Marathe, Rahul Rochani, Shams Ul Nisa* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):393-398 Aims and Objectives: To observe and compare the distribution of various palatal rugae patterns in western and northern Indian populations and to study the variations in male and female subjects respectively. Materials and Methods: The study consisted of 100 subjects, 50 each from the two groups of geographically different regions of western and northern India. After obtaining infor... περισσότερα »
Presentation of hypohidrotic ectodermal dysplasia in two siblings
Presentation of hypohidrotic ectodermal dysplasia in two siblings: *Uday Ginjupally, Balaji Babu Bangi, Lavanya Gadapa, Pooja Madki* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):476-478 Ectodermal dysplasias are a large hereditary group of disorders which are usually manifested as X-linked recessive disorders and have a full expression in males, whereas females show little to no signs of the disorder. The two most common types of ectodermal dysplasias are hypohidrotic ectodermal dysplasia (Christ-Siemens-Touraine syndrome) and hidrotic ectodermal dysplasia... περισσότερα »
Determination of salivary flow rate, pH, and dental caries during pregnancy: A study
Determination of salivary flow rate, pH, and dental caries during pregnancy: A study: *Amruta A Karnik, Sandeep S Pagare, Vasavi Krishnamurthy, Sonal P Vahanwala, Mandavi Waghmare* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):372-376 Introduction: Saliva is an important diagnostic biofluid and the salivary composition is affected by various systemic conditions including pregnancy. Aims: The study was conducted to evaluate the salivary flow rate and pH in pregnant and non-pregnant Indian women and, consequently, to compare and correlate the salivary flow ra... περισσότερα »
Unilateral condylar aplasia: A case report
Unilateral condylar aplasia: A case report: *Sagar S Joshi, Abhijeet Rajendra Sande, Mysore K Sunil, Ashwinirani Suragimath* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):445-448 Growth disturbances in the mandibular condyle region include aplasia, hypoplasia, and hyperplasia. Non-syndromic aplasia of the mandibular condyle is very rare, and may be due to congenital or acquired causes. The mandibular condyle is regarded as the center of mandibular growth. Therefore, regional disturbances during the growth phase may negatively impact mandibular growth. We pr...περισσότερα »
Efficacy of scintigraphy as a diagnostic aid in oral and maxillofacial pathologies: A comparative radionuclide-radiographic study
Efficacy of scintigraphy as a diagnostic aid in oral and maxillofacial pathologies: A comparative radionuclide-radiographic study: *Ankur Singh, Nitin Agarwal, Kamala Rawson, Basavaraj N Kallalli, Abhishek Sinha, Yatriben Sandesara* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):359-365 Aims and Objectives: The aim of this study was to investigate various lesions involving the oral and maxillofacial region by using scintigraphy and to compare the findings with those of conventional radiograph. Materials and Methods: Nineteen subjects of all age groups and bo... περισσότερα »
Familial non-syndromic oligodontia
Familial non-syndromic oligodontia: *Seema Basoya, Sridevi Koduri, Ishita Gupta, Vinod Vijay Chandar* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):437-440 Oligodontia, a rare genetic disorder, represents the congenital absence of more than six teeth in primary, permanent, or both dentitions and is usually the feature of a syndrome. Its occurrence as an isolated entity is even rarer. This article reports non-syndromic oligodontia in two siblings. One case also had concurrent maxillary canine transmigration as one of the rarest associated entities.
A study on the radiographic features of jaws and teeth in patients with thalassemia major using orthopantomograph
A study on the radiographic features of jaws and teeth in patients with thalassemia major using orthopantomograph: *Neera Ohri, Mubeen Khan, Nikita Gupta, Garima Bhatt, Parul Malhotra, Abhishek Ranjanpati* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):343-348 Aims and Objectives: Thalassemia is the most common gene disorder caused by mutations that decrease the rate of synthesis of α- or β-globin chains. Every year approximately 100,000 children with thalassemia major are born the world over, of which 10,000 are born in India. This study aimed to compare th... περισσότερα »
Bifid mandibular canal: An unusual presentation
Bifid mandibular canal: An unusual presentation: *Ajay Parihar, Shilpa A Warhekar, Harshakant P Gharote, Ashish M Warhekar* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):453-456 Bifid mandibular canal could be an interesting variation in the mandible. This condition can pose complications during surgical procedures in the mandible, such as extraction of lower molars, placement of implants, and surgery. Therefore, identification of this variation is sometimes very crucial and can assist in minimizing postoperative complications. Hereby, we report the presenc...περισσότερα »
Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET).Destructive radiolucent lesion involving right maxillary alveolus
Destructive radiolucent lesion involving right maxillary alveolus: Report of a rare case: *Manjiri Joshi, Rajendrasinh S Rathod, Arpan Shah, Rahul Thakkur* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):449-452 Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) usually arises in the long bones of extremities. It is uncommon to find ES in the head and neck region, particularly in gnathic bones. It comprises 6-8% of all primary bone malignancies. Only 1% of cases is reported with jaw involvement and has mandibular predilection. Even with early intervent... περισσότερα »
"Out of the ordinary": A case report of osteoma of mandibular condyle
"Out of the ordinary": A case report of osteoma of mandibular condyle: *Vaishali Mysore Rajshekar, Neelakantam Rajarathnam Basetty, Roopashri Govindaraju, Maria Priscilla David* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):441-444 Osteomas are relatively rare in the jaws. The causes of these lesions are unknown, although trauma, infection, and developmental abnormalities have been suggested as contributing factors. To the best of our knowledge, only 13 cases of osteomas of the condyle have been reported in literature. Here we report a rare case of osteoma ... περισσότερα »
Efficacy of vitamin E in oral submucous fibrosis: A clinical and histopathologic study
Efficacy of vitamin E in oral submucous fibrosis: A clinical and histopathologic study: *Venkateswarlu Nallapu, Bhavya Balasankulu, Hima Bindu Vuppalapati, Sailaja Sambhana, Dayanandam Mala, Sri Krishna Koppula* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):387-392 Introduction: Oral submucous fibrosis is a scarring progressive disease characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues, i.e., lamina propria and deeper connective tissues. An attempt was made in this study to evaluate the role of vitamin... περισσότερα »
Prevalence of oral soft tissue lesions and medical assessment of geriatric outpatients
Prevalence of oral soft tissue lesions and medical assessment of geriatric outpatients in North India: *Sameer Rastogi, Pallak Arora, Shalini Kapoor, Sartaj Singh Wazir, Shirin Vashishth, Vandana Sharma* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):382-386 Introduction: Oral health reflects overall well-being for the elderly population. Compromised oral health may be a risk factor for systemic diseases commonly occurring in old age. Oral health evaluation should be an integral part of the physical examination, and dentistry is essential to qualify geriatri... περισσότερα »
Hay-Wells syndrome: Report of a rare disorder with dental management
Hay-Wells syndrome: Report of a rare disorder with dental management: *Sonal B Dudhia, Bhavin B Dudhia, Jigna S Shah* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):492-496 Hay-Wells syndrome is a rare autosomal dominant disorder characterized by ankyloblepharon, ectodermal dysplasia, and cleft palate and/or cleft lip [ankyloblepharon-ectodermal dysplasia-clefting (AEC) syndrome]. Initially described by Hay and Wells in 1976, it is a rare form of ectodermal dysplasia with varying forms of expression featuring congenital abnormalities of the skin, hair, teeth...περισσότερα »
Detection of human papilloma virus (HPV) and human immunodeficiency virus (HIV) in oral squamous cell carcinoma: A polymerized chain reaction (PCR) study
Detection of human papilloma virus (HPV) and human immunodeficiency virus (HIV) in oral squamous cell carcinoma: A polymerized chain reaction (PCR) study: *Suresh Dirasantchu, Manjula Marthala, Sameeulla Shaik, Raviraj Jayam, Suman Sreeram Venkata, Vijaykumar Bokkasam* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):377-381 Aims and Objectives: Certain strains of human papillomavirus (HPV) have been shown to be etiologically related to the development of uterine, cervical, and other genital cancers, but their role in the development of malignancies at other s...περισσότερα »
Chameleon of head and neck diseases: Intraoral actinomycosis
Chameleon of head and neck diseases: Intraoral actinomycosis: *Srisha Basappa, Bharathi Ullagaddi, Mahesh Mysore Shivalingu, Late Naresh Lingaraju* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):461-463 Actinomycosis is a chronic infectious granulomatous disease caused by saprophytic Actinomyces species. The case discussed in this report is of an adult female patient with a large actinomycotic lesion in the region of the mandibular left second premolar, first and second molars. Provisional diagnosis was made as extragingival pyogenic granuloma. Definitive d... περισσότερα »
Correlation of morphological variants of soft palate and types of malocclusion: A digital lateral cephalometric study
Correlation of morphological variants of soft palate and types of malocclusion: A digital lateral cephalometric study: *Deepak Samdani, Anjali Saigal, Esha Garg* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):366-371 Aims and Objectives: The morphology of soft palate has variable presentations on lateral cephalometry. The aim of our study was to investigate the correlation between various shapes of soft palate and types of malocclusion in different gender groups among North Indian individuals. Materials and Methods: The study sample comprised randomly select... περισσότερα »
An etiological dilemma in osteomyelitis: A case report
An etiological dilemma in osteomyelitis: A case report: *Aparna Muraleedharan* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):500-503 Osteomyelitis is an acute or chronic inflammatory process that can involve cortical and trabecular aspects of bone or bone marrow. This case report describes an interesting presentation of chronic suppurative osteomyelitis in a 22-year-old male patient who visited the dental clinic with a chief complaint of facial asymmetry and esthetic concern only. The history, examination, radiographic and histopathological investigations c... περισσότερα »
Fractal analysis in oral leukoplakia
Fractal analysis in oral leukoplakia: *Prashant Bhai Pandey, Srinivas Kandakurti, Vasu S Saxena, Payal Tripathi, Ratnakar Pamula, Monu Yadav* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):354-358 Introduction: Fractal analysis (FA) quantifies complex geometric structures by generating a fractal dimension (FD), which can measure the complexity of mucosa. FA is a quantitative tool used to measure the complexity of self-similar or semi-self-similar structures. Aim and Objective: The study was done to perform the FA of oral mucosa with keratotic changes, as it i...περισσότερα »
Rare case of palatal schwannoma
Rare case of palatal schwannoma: Case report and review of literature: *Uday Shankar Yaga, Ashwini Kumar Mengji, Radhika Besta, Nishanth Gollamudi* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):484-487 Schwannomas, also known as neurilemmoma, are benign, slow-growing nerve sheath tumors arising from Schwann cells. Approximately 25-40% of schwannomas occur in the head and neck region. However, schwannomas that present in the oral cavity are relatively rare, constituting around 1% of all described cases in the head and neck region. [1],[2] Here, we report a r... περισσότερα »
FGF23-Associated Tumor-Induced Osteomalacia
FGF23-Associated Tumor-Induced Osteomalacia in a Patient With Small Cell Carcinoma: A Case Report and Regulatory Mechanism Study: Tumor-induced osteomalacia (TIO) is typically caused by phosphaturic mesenchymal tumor (PMT) that secretes the phosphaturic hormone, fibroblast growth factor-23 (FGF23), resulting in decreased phosphate reabsorption in kidneys, hypophosphatemia, and finally osteomalacia. Rare cases of malignant tumor manifesting with TIO other than PMT had been reported, although in most of these reports, except one, circulating FGF23 levels were not evaluated and tissue...περισσότερα »
Correlation of blood glucose level in gingival crevicular blood and finger capillary blood using glucometer
Correlation of blood glucose level in gingival crevicular blood and finger capillary blood using glucometer: *Supreet Jain, Mathod C Shashikanth, Jaideep Sur, Fatima Khan, Sheetal Mujoo, Deeplaxmi Dewangan* Journal of Indian Academy of Oral Medicine and Radiology 2015 27(3):338-342 Aim: The aim of the study was to assess the reliability of gingival crevicular blood (GCB) glucose level compared with finger capillary blood (FCB) glucose level using a glucose self-monitoring device (Contour ® TS). Materials and Methods: One hundred randomly selected patients with gingivitis (45 sub...περισσότερα »
A regional method for craniofacial reconstruction based on coordinate adjustments and a new fusion strategy
A regional method for craniofacial reconstruction based on coordinate adjustments and a new fusion strategy: Craniofacial reconstruction is a useful tool in the identification of skeletal remains when there is a lack of other forensic evidence to suggest an identity. For example, when human remains are disfigured, burnt, decomposed, or badly mutilated, craniofacial reconstruction can be a last resort to assist the investigation out of the impasse. The aim of craniofacial reconstruction is to recreate a likeness of the real face using the relationship between the soft tissues and the ... περισσότερα »
Postradiation dermatofibrosarcoma protuberans
Acta Chir Belg. Postradiation dermatofibrosarcoma protuberans : case report and literature review. Lin CT1, Chang SC, Chen TM, Lin HC, Chen SG. Author information 1Division of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Abstract Radiotherapy has long been known to induce soft tissue sarcomas. However, there are only six cases of postradiation dermatofibrosarcoma protuberans (DFSP) reported in the literature, and no case in Asians has been reported so far. Herein, we report a case of DFSP, con...περισσότερα »
A study of mastoid pneumatisation and the presence of cholesteatoma in 393 patients.
A study of mastoid pneumatisation and the presence of cholesteatoma in 393 patients.: CONCLUSION: The findings demonstrate the presence of cholesteatoma in well-pneumatised mastoids. It is hypothesised that a well-pneumatised mastoid may lead to cholesteatoma formation. PMID: 26592097 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology) J Laryngol Otol. 2015 Nov 23:1-3. [Epub ahead of print] A study of mastoid pneumatisation and the presence of cholesteatoma in 393 patients. Iqbal IZ1, Watson C2. Author information 1Department of Otolaryngology,North... περισσότερα »
Neodymium-doped yttrium aluminium garnet laser photocoagulation surgery for patients with epistaxis.
Long-term result of out-patient neodymium-doped yttrium aluminium garnet laser photocoagulation surgery for patients with epistaxis.: CONCLUSION: Neodymium-doped yttrium aluminium garnet laser photocoagulation is desirable in the treatment of both acute and recurrent epistaxis, and has long-lasting efficacy. PMID: 26600379 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology) J Laryngol Otol. 2015 Nov 24:1-6. [Epub ahead of print] Long-term result of out-patient neodymium-doped yttrium aluminium garnet laser photocoagulation surgery for patients with epi... περισσότερα »
Assessing potentially inappropriate prescribing (PIP) and predicting patient outcomes in older population
Assessing potentially inappropriate prescribing (PIP) and predicting patient outcomes in Ontarios older population: a population-based cohort study applying subsets of the STOPP/START and Beers criteria in large health administrative databases: Introduction Adverse drug events (ADEs) are common in older people and contribute significantly to emergency department (ED) visits, unplanned hospitalisations, healthcare costs, morbidity and mortality. Many ADEs are avoidable if attention is directed towards identifying and preventing inappropriate drug use and undesirable drug combinations...περισσότερα »
Chikungunya virus-associated encephalitis
Chikungunya virus-associated encephalitis: A cohort study on La Reunion Island, 2005-2009: Objective: To estimate the cumulative incidence rate (CIR) of Chikungunya virus (CHIKV)–associated CNS disease during the La Réunion outbreak, and assess the disease burden and patient outcome after 3 years. Methods: CHIKV-associated CNS disease was characterized retrospectively in a cohort of patients with positive CHIKV reverse transcriptase PCR or anti-CHIKV immunoglobulin M antibodies in the CSF and fulfilling International Encephalitis Consortium criteria for encephalitis or encephalopat...περισσότερα »
The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells
The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer [ANTIGEN RECOGNITION AND RESPONSES]: NY-ESO-1–specific CD4+ T cells are of interest for immune therapy against tumors, because it has been shown that their transfer into a patient with melanoma resulted in tumor regression. Therefore, we investigated how NY-ESO-1 is processed onto MHC class II molecules for direct CD4+ T cell recognition of melanoma cells. We could rule out proteasome and autophagy-dependent endogenous Ag processing for MHC class II presenta... περισσότερα »
Bidirectional Counterregulation of Human Lung Mast Cell and Airway Smooth Muscle {beta}2 Adrenoceptors
Bidirectional Counterregulation of Human Lung Mast Cell and Airway Smooth Muscle {beta}2 Adrenoceptors [ALLERGY AND OTHER HYPERSENSITIVITIES]: Human lung mast cells (HLMCs) play a central role in asthma pathogenesis through their relocation to the airway smooth muscle (ASM) bundles. β2 adrenoceptor (β2-AR)-agonists are used to relieve bronchoconstriction in asthma, but may reduce asthma control, particularly when used as monotherapy. We hypothesized that HLMC and human ASM cell (HASMC) responsiveness to β2-AR agonists would be attenuated when HLMCs are in contact with HASMCs. Cells... περισσότερα »
Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development
Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development [IMMUNE SYSTEM DEVELOPMENT]: Lunatic, Manic, and Radical Fringe (LFNG, MFNG, and RFNG) are N-acetylglucosaminyltransferases that modify Notch receptors and regulate Notch signaling. Loss of LFNG affects thymic T cell development, and LFNG and MFNG are required for marginal zone (MZ) B cell development. However, roles for MFNG and RFNG in T cell development, RFNG in B cell development, or Fringes in T and B cell activation are not identified. In this study, we show that *Lfng/Mfng/Rfng* triple knockout (*Fng* t... περισσότερα »
The Group B Streptococcus-Secreted Protein CIP Interacts with C4, Preventing C3b Deposition
The Group B Streptococcus-Secreted Protein CIP Interacts with C4, Preventing C3b Deposition via the Lectin and Classical Complement Pathways [INFECTIOUS DISEASE AND HOST RESPONSE]: The group B *Streptococcus* (GBS) is a leading cause of neonatal invasive disease. GBS bacteria are surrounded by a thick capsular polysaccharide that is a potent inhibitor of complement deposition via the alternative pathway. Several of its surface molecules can however activate the classical and lectin complement pathways, rendering this species still vulnerable to phagocytic killing. In this study we ...περισσότερα »
Serum Lipoproteins Are Critical for Innate Defense against Staphylococcus aureus Quorum Sensing
Serum Lipoproteins Are Critical for Pulmonary Innate Defense against Staphylococcus aureus Quorum Sensing [INFECTIOUS DISEASE AND HOST RESPONSE]: Hyperlipidemia has been extensively studied in the context of atherosclerosis, whereas the potential health consequences of the opposite extreme, hypolipidemia, remain largely uninvestigated. Circulating lipoproteins are essential carriers of insoluble lipid molecules and are increasingly recognized as innate immune effectors. Importantly, severe hypolipidemia, which may occur with trauma or critical illness, is clinically associated wit... περισσότερα »
Markerless Analysis of Articulatory Movements in Patients With Parkinson's Disease
Markerless Analysis of Articulatory Movements in Patients With Parkinson's Disease: A large percentage of patients with Parkinson's disease have hypokinetic dysarthria, exhibiting reduced peak velocities of jaw and lips during speech. This limitation implies a reduction of speech intelligibility for such patients. This work aims at testing a cost-effective markerless approach for assessing kinematic parameters of hypokinetic dysarthria. (Source: Journal of Voice)
Single-Immunization Protection against Inhaled Anthrax
A CpG-Ficoll Nanoparticle Adjuvant for Anthrax Protective Antigen Enhances Immunogenicity and Provides Single-Immunization Protection against Inhaled Anthrax in Monkeys [IMMUNOTHERAPY AND VACCINES]: Nanoparticulate delivery systems for vaccine adjuvants, designed to enhance targeting of secondary lymphoid organs and activation of APCs, have shown substantial promise for enhanced immunopotentiation. We investigated the adjuvant activity of synthetic oligonucleotides containing CpG-rich motifs linked to the sucrose polymer Ficoll, forming soluble 50-nm particles (DV230-Ficoll), each ... περισσότερα »
Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance
Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance: Article The high expression of the DNA repair enzyme O6-methylguanine DNA methyltransferase (MGMT) often confers resistance to chemotherapy in several cancers. In this study, the authors propose the inhibition of the Wnt signalling pathway as an alternative strategy to modulate MGMT expression and sensitize tumours to chemotherapy. Nature Communications doi: 10.1038/ncomms9904 Authors: Malin Wickström, Cecilia Dyberg, Jelena Milosevic, Christer Einvik, Raul Ca... περισσότερα »
Fazialisparese – wenn die Mimik erlischt
Fazialisparese – wenn die Mimik erlischt: Ursachen, Diagnose & Therapie Die mimische Gesichtsmuskulatur wird vom VII. Hirnnerven (N. facialis) innerviert. Erlischt seine Funktion, können funktionelle, ästhetische und psychosoziale Probleme resultieren. Wann und wie die Mimik wieder hergestellt werden kann. Original enclosures:
Visual processing in migraine
Visual processing in migraine: Background Migraine is a common neurological condition that often involves differences in visual processing. These sensory processing differences provide important information about the underlying causes of the condition, and for the development of treatments. Review of psychophysical literature Psychophysical experiments have shown consistent impairments in contrast sensitivity, orientation acuity, and the perception of global form and motion. They have also established that the addition of task-irrelevant visual noise has a greater effect, and that ... περισσότερα »
Spontaneous extracranial hemorrhagic phenomena in primary headache disorders
Spontaneous extracranial hemorrhagic phenomena in primary headache disorders: A systematic review of published cases: Background Head pain is a cardinal feature of primary headache disorders (PHDs) and is often accompanied by autonomic and vasomotor symptoms and/or signs. Spontaneous extracranial hemorrhagic phenomena (SEHP), including epistaxis, ecchymosis, and hematohidrosis (a disorder of bleeding through sweat glands), are poorly characterized features of PHDs. Aim To critically appraise the association between SEHP and PHDs by systematically reviewing and pooling all reports o...περισσότερα »
Software-Tool für Reintonaudiometrie
Software-Tool für Reintonaudiometrie: Zusammenfassung HintergrundDie Einschlusskriterien klinischer Studien zur Therapie von Hörverlust basieren oft auf dem Reintonaudiogramm. Bei Studien zur Therapie des idiopathischen plötzlichen sensorineuralen Hörverlusts (Hörsturz) wird das aktuelle Audiogramm oft mit einem Voraudiogramm, dem Audiogramm des nicht betroffenen Ohrs oder einem Normalaudiogramm nach ISO 7029 verglichen. Üblicherweise werden deutlich mehr Patienten gescreent als tatsächlich die Einschlusskriterien erfüllen. Bei allen müssen oftmals aufwendige Berechnungen des Hörv... περισσότερα »
Inhibition of STAT3 activity delays obesity-induced thyroid carcinogenesis
Inhibition of STAT3 activity delays obesity-induced thyroid carcinogenesis in a mouse model: Compelling epidemiologic studies indicate that obesity is a risk factor for many human cancers, including thyroid cancer. In recent decades, the incidence of thyroid cancer has dramatically increased along with a marked rise in obesity prevalence. We previously demonstrated that a high fat diet (HFD) effectively induced the obese phenotype in a mouse model of thyroid cancer (*Thrb**PV/PV**Pten**+/–* mice). Moreover, HFD activates the STAT3 signal pathway to promote more aggressive tumor phe... περισσότερα »
Food-antigen–specific immunoglobulin E is not a predictor of food allergies in atopic dermatitis
Food-antigen–specific immunoglobulin E is not a predictor of food allergies in atopic dermatitis: Food-antigen–specific immunoglobulin E (sIgE) levels were not clinically useful for predicting food allergy development in a study of infants with atopic dermatitis (AD). The dual-phase study included 1,087 patients aged 3-18 months who had been diagnosed with AD for no more than 3 months prior to... (Source: Skin and Allergy News)
Psoriasis and Migraine: What's the Connection?Psoriasis and Migraine: What's the Connection?
Psoriasis and Migraine: What's the Connection?Psoriasis and Migraine: What's the Connection?: A disease severity-dependent increased risk for migraine in psoriasis and increased risk for new-onset migraine in psoriatic arthritis could be mediated by the usual suspects--proinflammatory cytokines. Medscape Dermatology (Source: Medscape Allergy Headlines)
Subglottic Squamous Cell Carcinoma: A Population-Based Study
Subglottic Squamous Cell Carcinoma: A Population-Based Study of 889 Cases: Objective Subglottic squamous cell carcinoma (SCCa) is a rare malignancy representing <5% of all laryngeal cancers. Patients often present with late-stage disease, and survival outcomes are reportedly worse than those for SCCa in other regions of the larynx. Study Design Analysis of a population-based tumor registry. Setting Academic medical center. Subjects and Methods The US National Cancer Institute’s Surveillance, Epidemiology, and End Results database was queried for cases of subglottic SCCa from 197... περισσότερα »
Reoperative Parathyroidectomy: Overly Descended Superior Adenoma
Reoperative Parathyroidectomy: Overly Descended Superior Adenoma: Objectives To identify the importance of the ectopic, overly descended superior parathyroid adenoma variant and its prevalence in primary and reoperative parathyroid surgery and the implications for successful initial parathyroidectomy. Study Design Case series with planned data collection. Setting Tertiary endocrine surgery practice in an academic medical center. Subjects and Methods An analysis was undertaken of 561 consecutive patients undergoing parathyroid surgery in a tertiary endocrine surgery practice from ... περισσότερα »
Drug-induced sleep-endoscopy in children's sleep related breathing disorders
Exploración videosomnoscópica bajo sueño inducido en los trastornos respiratorios del sueño en niños via ScienceDirect Publication Acta Otorrinolaringológica Española Publication date: Available online 25 November 2015 *Source:*Acta Otorrinolaringológica Española Author(s): Eduard Esteller, Demetrio Mulas, Raúl Haspert, Eusebi Matiñó, Roser López, Montserrat Girabent-Farrés Introducción y objetivosLa somnoscopia es una herramienta válida para evaluar los lugares de obstrucción de la vía aérea superior responsables del síndrome de apnea-hipoapnea del sueño infantil.El objetivo es mostrar... περισσότερα »
Orbital emphysema after blowing the nose
Enfisema periorbitario tras sonarse la nariz via ScienceDirect Publication Acta Otorrinolaringológica Española Publication date: Available online 25 November 2015 *Source:*Acta Otorrinolaringológica Española Author(s): Frank Alberto Betances Reinoso, Carlos Miguel Chiesa Estomba, Alejandra Osorio Velasquez Figures and tables 1. [image: Image for figure Figura 1] 2. [image: Image for figure Figura 2] 3. [image: Image for figure Figura 3]
Corticosteroid therapy and airflow obstruction influence the bronchial microbiome
, which is distinct from that of bronchoalveolar lavage in asthmatic airways via Journal of Allergy and Clinical Immunology Publication date: Available online 25 November 2015 *Source:*Journal of Allergy and Clinical Immunology Author(s): Darcy R. Denner, Naseer Sangwan, Julia B. Becker, D. Kyle Hogarth, Justin Oldham, Jamee Castillo, Anne I. Sperling, Julian Solway, Edward T. Naureckas, Jack A. Gilbert, Steven R. White BackgroundThe lung has a diverse microbiome that is modest in biomass. This microbiome differs in asthmatic patients compared with control subjects, but the effects of c...περισσότερα »
Serum 25-hydroxyvitamin D3 levels in children with allergic or nonallergic rhinitis
Serum 25-hydroxyvitamin D3 levels in children with allergic or nonallergic rhinitis: The relationship between vitamin D and allergic diseases such as asthma and atopic dermatitis is shown in several studies. But there is a lack of knowledge about vitamin D status in children with allergic rhinitis (AR). We aimed to investigate serum vitamin D levels of children with AR or nonallergic rhinitis (NAR), to compare with normal subjects and to evaluate the relationship between vitamin D and the severity of AR. AbstractObjectives The relationship between vitamin D and allergic diseases suc... περισσότερα »
Rat model of chronic tympanic membrane perforation: Ventilation tube with mitomycin C and dexamethasone
Rat model of chronic tympanic membrane perforation: Ventilation tube with mitomycin C and dexamethasone: Chronic tympanic membrane perforation (TMP) in a clinical setting may attract surgical intervention. With the advent of modern biomaterials, new options are available for myringoplasty but safety and efficacy need evaluation in a chronic TMP animal model. The aim of this study was to evaluate the efficacy of ventilation tube (VT) insertion in conjunction with topical application of mitomycin C/dexamethasone (M/D) for the creation of chronic TMP. AbstractObjective Chronic tympani...περισσότερα »
Decreased salivary matrix metalloproteinase-8 reflecting a defensive potential in juvenile parotitis
Decreased salivary matrix metalloproteinase-8 reflecting a defensive potential in juvenile parotitis: Matrix metalloproteinases MMP-2 and MMP-9 have been associated with juvenile parotitis. However, the role of MMP-8 has not been addressed previously. This work focuses on salivary MMP-8 and -9 levels in juvenile parotitis. AbstractObjective Matrix metalloproteinases MMP-2 and MMP-9 have been associated with juvenile parotitis. However, the role of MMP-8 has not been addressed previously. This work focuses on salivary MMP-8 and -9 levels in juvenile parotitis. Methods During a fiv...περισσότερα »
Defective sirtuin-1 increases IL-4 expression
Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma via Journal of Allergy and Clinical Immunology Publication date: Available online 25 November 2015 *Source:*Journal of Allergy and Clinical Immunology Author(s): Thomas Colley, Nicolas Mercado, Yuichi Kunori, Christopher Brightling, Pankaj K. Bhavsar, Peter J. Barnes, Kazuhiro Ito Letter to the Editor Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma To the Editor: Patients with severe asthma are poorly responsive to current... περισσότερα »
Tooth injury in anaesthesiology
*Tooth injury in anaesthesiology* *by Brazilian Journal of Anesthesiology via MedWorm Laryngoscopy* *Conclusions Before initiating any medical procedure that requires the use of classic laryngoscopy, a thorough and detailed pre-aesthetic evaluation of the dental status of the patient is imperative, in order to identify teeth at risk, analyze the presence of factors associated with difficult intubation and outline a prevention strategy that is tailored to the risk of dental injury of each patient. (Source: Brazilian Journal of Anesthesiology)* AbstractBackground and objectives *Dental ... περισσότερα »
Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: Randomized multicenter split-mouth clinical trial
Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: Randomized multicenter split-mouth clinical trial: Background: Impacted third molar removal is a routine procedure in oral and maxillofacial surgery. Platelet-rich fibrin (PRF) is a second generation platelet concentration which is produced by simplified protocol. The aim of this study was to assess the effectiveness of PRF in the healing process by evaluating the changes in pain and swelling after third molar surgery. Methods: Fifty-six patients (23 male, 33 female) who prov... περισσότερα »
Thymic choristoma of the middle ear presenting as a red, tympanic mass
Thymic choristoma of the middle ear presenting as a red, tympanic mass: Thymic choristoma is a very rare disease that can arise along the anatomical route through which the thymus, during development, migrates towards the upper mediastinum. Most thymic choristomas are easily mistaken for lymphadenitis or a lymph hemangioma prior to surgery and are very difficult to diagnose clinically.[1] Thymic choristoma arising in the middle ear is a very rare case which has yet to be reported. We have recently experienced a case wherein a thymic choristoma was discovered in the middle ear of a 4...περισσότερα »
Chemotherapy in Children with Head and Neck Cancers
Chemotherapy in Children with Head and Neck Cancers: This article focuses on the common chemotherapeutic agents, with a particular focus on early and late effects, used in the treatment of children with head and neck cancers. (Source: Oral and Maxillofacial Surgery Clinics)
Pediatric Odontogenic Tumors
Pediatric Odontogenic Tumors: This article discusses the diagnosis and treatment of the most common pediatric odontogenic tumors, such as ameloblastoma, keratocystic odontogenic tumor, odontoma, and cementoblastoma. (Source: Oral and Maxillofacial Surgery Clinics)
Nonodontogenic Tumors of the Jaws
Nonodontogenic Tumors of the Jaws: This article focuses on the clinical characteristics and management of the benign nonodontogenic tumors (nonaggressive and aggressive) of the jaws most commonly encountered in children. (Source: Oral and Maxillofacial Surgery Clinics)
Nonodontogenic Cysts of the Jaws and Treatment in the Pediatric Population
Nonodontogenic Cysts of the Jaws and Treatment in the Pediatric Population: This article reviews common clinical findings, radiographic features, histopathologic features, and current treatments of nonodontogenic cysts. (Source: Oral and Maxillofacial Surgery Clinics)
Strategies to Overcome Late Complications from Radiotherapy for Childhood Head and Neck Cancers
Strategies to Overcome Late Complications from Radiotherapy for Childhood Head and Neck Cancers: This article discusses the common long-term complications associated with head and neck radiotherapy for childhood cancers. It reviews approaches to minimize toxicity and details the toxicities that head and neck radiation inflicts on relevant functional measures. In addition, it discusses the risk of radiation-induced secondary cancers in childhood cancer survivors, as well as strategies to reduce them. Thus, this article addresses approaches to minimize long-term radiation toxicities i... περισσότερα »
The proximally-based long peroneal muscle turn-over flap: a novel salvage flap for small to medium-sized defects of the knee
Coverage of soft tissue defects of the knee due to multiple operations, trauma and infection remains a surgical challenge. Often, these defects are repaired using free tissue transfer. The aim of the current study was to find an easy and reliable local method of repair for small to medium-sized defects. The authors describe a new surgical option for tissue coverage using a proximally-based long peroneal muscle turnover flap (LPTF) with split-thickness skin graft. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1YvtL9c via IFTTT
TDAP: Island vs. Propeller
Thoracodorsal artery perforator (TDAP) island flap is a safe and reliable method for breast reconstruction. TDAP propeller flap has been described as a modification of the conventional island technique that saves time and does not require microsurgical skills. However, a substantial portion of the propeller flap remains under the axilla and is not used for breast augmentation. The purpose of this study is to identify the differences in the reaching distances between the propeller and island TDAP flaps. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1Ic6Mfe v... περισσότερα »
Comparative study of intercostal nerve transfer to lower trunk and contralateral C7 root transfer in repair of total brachial plexus injury in rats
The purpose of the experimental study is to compare the treatment outcome of nerve transfer using intercostal nerves (ICNs) or contralateral C7 (cC7) root in rats. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1YvtL93 via IFTTT
Myosonographic Study of Abdominal Wall Dynamics to Assess Donor Site Morbidity after Microsurgical Breast Reconstruction with a DIEAP or ms-2 TRAM Flap
Today, autologous breast reconstruction with a free tissue transfer from the lower abdomen is considered to be a well-established and safe method that provides a stable, long term solution. The DIEAP flap and the ms-2 TRAM flap have helped to reduce donor site morbidity. To assess potential differences between the two techniques, we carried out myosonographic evaluations that assessed the muscle dynamics of the abdominal wall pre- and post-operatively. In addition to investigating the properties of the rectus abdominis muscle post-operatively, this prospective study also allowed u... περισσότερα »
Nonodontogenic Cysts of the Jaws and Treatment in the Pediatric Population
Nonodontogenic Cysts of the Jaws and Treatment in the Pediatric Population: This article reviews common clinical findings, radiographic features, histopathologic features, and current treatments of nonodontogenic cysts. (Source: Oral and Maxillofacial Surgery Clinics)
Pediatric Head and Neck Malignancies
Pediatric Head and Neck Malignancies: This article presents an overview of pediatric head and neck malignancies with emphasis on diagnosis and management. (Source: Oral and Maxillofacial Surgery Clinics)
Pediatric Salivary Gland Malignancies
Pediatric Salivary Gland Malignancies: This article reviews current concepts in demographics, etiology, management, and outcomes of malignant salivary tumors in children. (Source: Oral and Maxillofacial Surgery Clinics)
Pediatric Benign Soft Tissue Oral and Maxillofacial Pathology
Pediatric Benign Soft Tissue Oral and Maxillofacial Pathology: Despite the many types of oral pathologic lesions found in infants and children, the most commonly encountered are benign soft tissue lesions. The clinical features, diagnostic criteria, and treatment algorithms of pathologies in the age group from birth to 18 years of age are summarized based on their prevalence in each given age distribution. Treatment modalities include both medical and surgical management. (Source: Oral and Maxillofacial Surgery Clinics)
Pediatric Odontogenic Cysts of the Jaws
Pediatric Odontogenic Cysts of the Jaws: Odontogenic cysts represent a common form of pathology of the jaws, and the natural history, clinicopathologic findings, and appropriate management strategies are important to the oral and maxillofacial surgeon. Odontogenic cysts in the pediatric populations are important pathologic entities given their potential impact on the growth and development of the maxillofacial complex. Inappropriate management strategies can severely affect the form and function of the growing child. Categorizing pediatric odontogenic cysts into inflammatory or deve... περισσότερα »
Benign Pediatric Salivary Gland Lesions
Benign Pediatric Salivary Gland Lesions: This article reviews benign neoplastic and nonneoplastic salivary gland disorders in pediatric patients to help clinicians to develop an orderly differential diagnosis that will lead to expedient treatment of pediatric patients with salivary gland lesions. (Source: Oral and Maxillofacial Surgery Clinics)
Combination therapy can prevent cytostatic resistance
Researchers at Karolinska Institutet have found a new way of preventing resistance to cytostatics used in the treatment of cancers such as medulloblastoma, the most common form of malignant brain tumour in children. The promising results of this experimental study are based on a combination of the drug temozolomid and other extant drugs that inhibit an enzyme instrumental in DNA repair in cancer cells. The study, which is published in the journal Nature Communications, was conducted on human tumour cells and on mice, and offers hope of a much improved therapy for a severe form of ...περισσότερα »
The isolated orbital floor fracture from a transconjunctival or subciliary perspective-A standardized anthropometric evaluation.
*The isolated orbital floor fracture from a transconjunctival or subciliary perspective-A standardized anthropometric evaluation.* Med Oral Patol Oral Cir Bucal. 2015 Nov 22;:0 Authors: Raschke G, Djedovic G, Peisker A, Wohlrath R, Rieger U, Guentsch A, Gomez-Dammeier M, Schultze-Mosgau S Abstract BACKGROUND: The influence of orbital fractures and their repair on the rate of deformities of the lower eyelid is an ongoing source of discussion in the literature. Most of the present studies include isolated blow-out as well as combined orbital fractures. MATERIAL AND METHODS: We pres...περισσότερα »
Multidisciplinary management of ankyloglossia in childhood. Treatment of 101 cases. A protocol.
*Multidisciplinary management of ankyloglossia in childhood. Treatment of 101 cases. A protocol.* Med Oral Patol Oral Cir Bucal. 2015 Nov 22;:0 Authors: Ferrés-Amat E, Pastor-Vera T, Ferrés-Amat E, Mareque-Bueno J, Prats-Armengol J, Ferrés-Padró E Abstract BACKGROUND: Partial ankyloglossia is a limitation which restricts the possibility of protrusion and elevation of the tip of the tongue due to the shortness of either the lingual frenulum or the genioglossus muscles or both. The principal objective of this paper is to present our protocol of action for the treatment of ankylogl... περισσότερα »
Association of susceptible genotypes to periodontal disease with the clinical outcome and tooth survival after non-surgical periodontal therapy: A systematic review and meta-analysis.
*Association of susceptible genotypes to periodontal disease with the clinical outcome and tooth survival after non-surgical periodontal therapy: A systematic review and meta-analysis.* Med Oral Patol Oral Cir Bucal. 2015 Nov 22;:0 Authors: Chatzopoulos GS, Doufexi AE, Kalogirou F Abstract BACKGROUND: The real clinical utility of genetic testing is the prognostic value of genetic factors in the clinical outcome of periodontal treatment and the tooth survival. A meta-analysis was undertaken to estimate the effect of a susceptible genotype to periodontitis on the clinical outcomes ... περισσότερα »
Expression of NF-κB and IL-6 in oral precancerous and cancerous lesions: An immunohistochemical study.
*Expression of NF-κB and IL-6 in oral precancerous and cancerous lesions: An immunohistochemical study.* Med Oral Patol Oral Cir Bucal. 2015 Nov 22;:0 Authors: Kamperos G, Nikitakis N, Sfakianou A, Avgoustidis D, Sklavounou-Andrikopoulou A Abstract BACKGROUND: The purpose of this study was to evaluate the immunohistochemical expression of NF-κB and IL-6 in oral premalignant and malignant lesions and to investigate their possible correlation with the presence of subepithelial inflammation. MATERIAL AND METHODS: Thirty two oral premalignant lesions, clinically compatible with leuk... περισσότερα »
Evaluation of Xerostomia and salivary flow rate in Hashimoto's Thyroiditis.
*Evaluation of Xerostomia and salivary flow rate in Hashimoto's Thyroiditis.* Med Oral Patol Oral Cir Bucal. 2015 Nov 22;:0 Authors: Agha-Hosseini F, Shirzad N, Moosavi MS Abstract BACKGROUND: One of the most common causes of hypothyroidism is Hashimoto's Thyroiditis (HT). Early detection of dry mouth is critical in preserving and promoting systemic and oral health. In this study we have assessed, for the first time, salivary function and xerostomia in HT patients who have not been involved with Sjögren's syndrome. MATERIAL AND METHODS: HT was diagnosed in 40 patients based on cl...περισσότερα »
Relation between diagnosis of atheromatous plaque from orthopantomographs and cardiovascular risk factors. A study of cases and control subjects.
*Relation between diagnosis of atheromatous plaque from orthopantomographs and cardiovascular risk factors. A study of cases and control subjects.* Med Oral Patol Oral Cir Bucal. 2015 Nov 22;:0 Authors: Barona-Dorado C, Gutierrez-Bonet C, Leco-Berrocal I, Fernández-Cáliz F, Martínez-González JM Abstract BACKGROUND: In recent years the use of orthopantomography has been proposed as a low-cost, reliable and non-invasive diagnostic medium for detecting atheromatous plaque. The purpose of this study was to correlate the presence of carotid calcifications (atheroma) in orthopantomogra... περισσότερα »
Pediatric Odontogenic Cysts of the Jaws
Pediatric Odontogenic Cysts of the Jaws: Odontogenic cysts represent a common form of pathology of the jaws, and the natural history, clinicopathologic findings, and appropriate management strategies are important to the oral and maxillofacial surgeon. Odontogenic cysts in the pediatric populations are important pathologic entities given their potential impact on the growth and development of the maxillofacial complex. Inappropriate management strategies can severely affect the form and function of the growing child. Categorizing pediatric odontogenic cysts into inflammatory or deve... περισσότερα »
Medication‐induced salivary gland dysfunction
World Workshop on Oral Medicine VI: A systematic review of medication‐induced salivary gland dysfunction: ConclusionsAlthough many medications may affect the salivary flow rate and composition, most of the studies considered only xerostomia. Thus, further human studies are necessary to improve our understanding of the association between MISGD and the underlying pathophysiology.This article is protected by copyright. All rights reserved. (Source: Oral Diseases) Clin Oral Investig. 2015;19(7):1563-80. doi: 10.1007/s00784-015-1488-2 World Workshop on Oral Medicine VI: a systematic ... περισσότερα »
Human lactoferrin protects against Streptococcus mutans induced caries
Human lactoferrin protects against Streptococcus mutans induced caries in mice: ConclusionThese results show that endogenous LF protects against S. mutans induced caries and that exogenous hLF can exert a protective effect against caries development.This article is protected by copyright. All rights reserved. (Source: Oral Diseases)
Remodelling the facial bones with a soft moulding helmet
Long-term results of remodelling the facial bones with a soft moulding helmet in beagles: the “reciprocally stimulated growth” hypothesis via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 25 November 2015 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Hyoseob Lim, Jaiho Chung, Dong Ha Park, Soo Han Yoon Facial deformity is often seen in infants with deformational plagiocephaly and it usually improves with conservative management. However, we know of few studies of the effect of helmet treatment on the facial skeleton. Our aim...περισσότερα »
Correcting epicanthal folds by using asymmetric Z-plasty with a two curve design
Correcting epicanthal folds by using asymmetric Z-plasty with a two curve design: The epicanthus is the oblique or vertical skin fold located medial to the medial canthus. A significant epicanthal fold can partially cover the caruncula lacrimalis and extend the space between the inner canthi.
Fructose Coingestion Does Not Accelerate Postexercise Muscle Glycogen Repletion.
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Background: Post-exercise muscle glycogen repletion is largely determined by the systemic availability of exogenous carbohydrate provided. Purpose: This study aimed to assess the effect of the combined ingestion of fructose and glucose on post-exercise muscle glycogen repletion when optimal amounts of carbohydrate are ingested. Methods: Fourteen male cyclists (age: 28+/-6 y; Wmax: 4.8+/-0.4 W[middle dot]kg-1) were studied on 3 different occasions. Each test day started with a glycogen-depleting exercise session. This was followed by a 5 h recovery period, during which subjects inges...περισσότερα »
Longitudinal Relationship Between Cardiorespiratory Fitness and Academic Achievement.
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Purpose: The aim was to examine the prospective associations between CRF and academic achievement in youth. Methods: The sample included 1286 fifth-, sixth-, and seventh-grade students, aged 11 to 14 years (Mage=11.3+/-1.1), from 14 schools followed for 3 years. Academic achievement was assessed using students' marks at baseline and at follow-up three years apart, in Portuguese, Mathematics, Foreign Language (English) and Science. CRF was assessed by the PACER test from Fitnessgram battery. Students were classified as fit-fit, unfit-fit, fit-unfit, and unfit-unfit according to PACER... περισσότερα »
Sensory Enhancing Insoles Modify Gait During Inclined Treadmill Walking With Load.
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Introduction: Inclined walking while carrying a loaded backpack induces fatigue, which may destabilize gait and lead to injury. Stochastic resonance (SR) technology has been used to stabilize spatiotemporal gait characteristics of elderly individuals but has not been tested on healthy recreational athletes. Herein, we determined if sustained vigorous walking on an inclined surface while carrying a load de-stabilizes gait and if SR has a further effect. Methods: Participants were fitted with a backpack weighing 30% of their body weight and asked to walk at a constant self-selected pa... περισσότερα »
Mood disorders in healthy elderly with obstructive sleep apnea: a gender effect
• A link between depression and obstructive sleep apnea (OSA) has been described.• We examined this association in a large group of healthy elderly with OSA.• No association was found between indices of respiratory disorder and depression.• Female gender was the strong predictor of depressive symptoms. from #SleepMedicine via ola Kala on Inoreader http://ift.tt/1OhEG3r via IFTTT
Clinical course of H1N1-vaccine-related narcolepsy
• Clinical course and quality of life in Pandemrix-related narcolepsy was analyzed.• Depression scores were lower on follow-up visit.• Lower hypocretin levels correlated with more severe phenotype.• Clinical course of Pandemrix-related narcolepsy was very heterogeneous.• Evolution of Pandemrix-related narcolepsy seems similar to sporadic narcolepsy. from #SleepMedicine via ola Kala on Inoreader http://ift.tt/1OhEDoe via IFTTT
Sleep-disordered breathing among acute ischemic stroke patients in Brazil
• Obstructive sleep apnea (OSA) is very frequent in Brazilian patients with acute stroke.• Severe OSA was associated with a poor long-term functional outcome following stroke.• OSA is a treatable condition and therefore its treatment seems to be a potential target to improve outcome of acute stroke patients. from #SleepMedicine via ola Kala on Inoreader http://ift.tt/1OhEFMP via IFTTT
