Methods of evaluation of smell in victims of subarachnoid hemorrhage patients: a systematic review
Methods of evaluation of smell in victims of subarachnoid hemorrhage patients: a systematic review: RESUMO Objetivos: Revisar de forma sistemática os métodos para avaliação do olfato em vítimas de hemorragia subaracnóidea aneurismática, e identificar as alterações encontradas com a utilização desses métodos. Estratégia de pesquisa: A pesquisa bibliográfica foi realizada na plataforma de busca PubMed e nas bases de dados Web of Science, Scopus, PsycINFO, CINAHL e ScienceDirect, tendo a busca de dados ocorrida em agosto e setembro de 2014. Critérios de seleção: Artigos originais publi... περισσότερα »
Can speech-evoked Auditory Brainstem Response become a useful tool in clinical practice?
Can speech-evoked Auditory Brainstem Response become a useful tool in clinical practice?: RESUMO Objetivo: Discutir a aplicabilidade clínica do Potencial Evocado Auditivo com Estímulo de Fala (PEATEf) no auxílio à identificação dos transtornos do processamento auditivo. Métodos : Foram selecionados os prontuários de 27 crianças e adolescentes, com idade entre sete e 15 anos, que apresentaram alteração no PEATEf. Foram levantados os dados referentes à avaliação comportamental do processamento auditivo desses indivíduos. Resultados: Observou-se que das 27 crianças com PEATEf alterado,... περισσότερα »
Oropharyngeal swallowing in chronic renal failure
Oropharyngeal swallowing in chronic renal failure: RESUMO Objetivo: Caracterizar o perfil de deglutição orofaríngea em indivíduos com insuficiência renal crônica (IRC). Métodos: Estudo clínico transversal do qual participaram 20 indivíduos adultos com diagnóstico médico de IRC, durante o período de internação hospitalar. A avaliação objetiva da deglutição foi realizada por videofluoroscopia de deglutição (VFD), sendo a caracterização e classificação dos achados baseada em parâmetros de eficácia e segurança. Além disso, foi aplicada a Functional Oral Intake Scale (FOIS). Resultados: ...περισσότερα »
Frequency and factors associated with dysphagia in stroke
Frequency and factors associated with dysphagia in stroke: RESUMO Objetivo: Verificar a frequência de disfagia em pacientes acometidos por acidente vascular cerebral (AVC) e investigar possíveis fatores sociodemográficos e clínicos associados. Método: Trata-se de estudo descritivo do tipo transversal em que foram avaliados 100 pacientes admitidos com o diagnóstico de AVC no Hospital Público Regional de Minas Gerais. Dados sociodemográficos e clínicos foram obtidos, e os pacientes, submetidos à avaliação clínica da deglutição por meio da escala Gugging Swallowing Screen (GUSS). Resul... περισσότερα »
Immediate effect of laryngeal manual therapy in dysphonic individuals
Immediate effect of laryngeal manual therapy in dysphonic individuals: RESUMO Objetivos: Verificar o efeito imediato da terapia manual laríngea (TML) na dor musculoesquelética, na voz e nas sensações autorreferidas em indivíduos com disfonia funcional/organofuncional de origem comportamental e em indivíduos sem disfonia. Métodos: Participaram 30 indivíduos do gênero feminino e masculino, com idade entre 18 e 45 anos. Foram divididos em grupo disfônico (GD), 15 indivíduos com disfonia funcional/organofuncional; e grupo controle (GC), 15 indivíduos com vozes saudáveis, sem queixas voc... περισσότερα »
Condition of Vocal Production-Teacher questionnaire: comparison of responses on Likert scale and visual analog scale
Condition of Vocal Production-Teacher questionnaire: comparison of responses on Likert scale and visual analog scale: RESUMO Objetivo: Comparar as respostas referentes aos sintomas vocais em duas versões do questionário Condição de Produção Vocal - Professor (CPV-P), com respostas em escala Likert e em escala visual analógica (EVA), para avaliar qual é a melhor forma de aferição. Métodos: Estudo observacional transversal realizado com professoras em atendimento por distúrbio de voz no período de julho de 2011 a julho de 2012. Todas responderam ao questionário CPV-P em duas versões: ... περισσότερα »
The antioxidant α-tocopherol succinate on cisplatin-induced ototoxicity in HEI-OC1 auditory cells
The effects of via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 12 April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Sung Kyun Kim, Gi Jung Im, Yun Suk An, Se Hee Lee, Hak Hyun Jung, Sang Yoo Park ConclusionD-α-tocopherol succinate significantly reduced a cisplatin-induced hair cell loss in HEI-OC1 cell lines. These effects were mediated by its scavenging activity against reactive oxygen species (ROS) and inhibition of apoptosis.ObjectivesAlpha-tocopherol is a class of methylated phenols, known as fat-sol... περισσότερα »
Asymptomatic group a streptococcus carriage in children with recurrent tonsillitis and tonsillar hypertrophy
Asymptomatic group a streptococcus carriage in children with recurrent tonsillitis and tonsillar hypertrophy via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 12 April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Isabela P Olivetti Pontin, Daniela Cristina Janolli Sanchez, Renata Di Francesco BackgroundGroup A Streptococcus (GAS) is the most important bacterial cause of acute tonsillitis in children. Some children are chronic GAS carriers, and this carriage is poorly understood. We determined the frequency of... περισσότερα »
Deaf or hard of hearing children : early intervention services
in saudi arabia: status of early intervention services via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 12 April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Huda Alyami, Maggi Soer, Lidia Pottas ObjectiveTo determine the status of early intervention services provided to children who are deaf or hard of hearing and their parents/caregivers from birth to five years of age at two main state hospitals in Riyadh, Saudi Arabia, based on their parents' perceptions.MethodA descriptive quantitative research design ... περισσότερα »
Mucocele of the hard palate
in children via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Mosaad Abdel-Aziz, Badawy Khalifa, Ahmed Nassar, Ahmed Kamel, Nader Naguib, Abdel-Rahman El-Tahan ObjectiveMucus retention cyst of the hard palate may result from obstruction of the ducts of the minor salivary glands, and it was defined as a mucocele. Although, the disease is not common in the hard palate, it was previously reported by many authors in the soft palate. The aim of our study was to present... περισσότερα »
Infants with profound hearing loss : Diverse etiologies manifesting auditory neuropathy characteristics
from infants with profound hearing loss and clinical implications via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 12 April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Shin Hye Kim, Hyun Seok Choi, Young Eun Han, Byung Yoon Choi ObjectiveAuditory neuropathy spectrum disorder (ANSD) is a hearing disorder with impaired signal transmission from the inner ear to the brain. The electrophysiological characteristics of auditory neuropathy (AN characteristics) are marked with presence of otoacoustic emissions (OAE)...περισσότερα »
CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy Study for Early-stage Glottic Larynx Cancer
CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy Study for Early-stage Glottic Larynx Cancer: *Condition*: Early-stage Glottic Larynx Cancer *Intervention*: Radiation: CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy *Sponsor*: University of Texas Southwestern Medical Center ArmsAssigned Interventions Experimental: Radiation CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy Radiation: CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy Detailed Description:Patients enrolled at ...περισσότερα »
Pregabalin in the Management of Mucositis Pain in Patients Undergoing Chemoradiation Therapy to the Head and Neck.
A Pilot Study at a Single-Institution of *Conditions*: Oropharyngeal Cancer; Squamous Cell Carcinoma to the Head and Neck *Intervention*: Drug: Lyrica 300 mg *Sponsor*: Abramson Cancer Center of the University of Pennsylvania To assess the efficacy of pregabalin in the management of mucositis pain in patients receiving radiotherapy to the head and neck. Eligible study subjects will be enrolled among those being treated for oropharyngeal cancer with definitive chemotherapy and radiation therapy (photons) to the head and neck in the Department of Radiation Oncology at the ... περισσότερα »
Mucosal Sparing Proton Beam Therapy (PBT) in Resected Oropharyngeal Tumors
A Study of Mucosal Sparing Proton Beam Therapy (PBT) in Resected Oropharyngeal Tumors: *Condition*: Oropharyngeal Tumor *Intervention*: *Sponsor*: Mayo Clinic This study is an observational study evaluating the clinical outcomes of deintensified proton beam therapy (PBT) after resection of favorable risk oropharyngeal cancer patients. Subjects will be screened at outpatient clinic visit appointments and interested qualified subjects will be consented and offered participation in this study. Once consent has been obtained baseline adverse event and Quality of Life (QOL) dat... περισσότερα »
Congenital Temporomandibular Joint Ankylosis
Case Report and Literature Review: Congenital temporomandibular joint (TMJ) ankylosis is an uncommon condition that presents itself at or soon after birth in the absence of acquired factors that could have contributed to the ankylosis such as infection and trauma. The experience of managing one such case is reported in light of a review of the literature on this condition. Key management principles include adequate removal of the ankylotic mass, costochondral grafting, and post-op physiotherapy. Most patients reported in the literature with the condition experienced relapse. This ech... περισσότερα »
Primary Mammary Analog Secretory Carcinoma (MASC) of the Thyroid Masquerading as Papillary Thyroid Carcinoma: Potentially More than a One Off
A Case of AbstractWe present the second reported mammary analog secretory carcinoma (MASC) apparently arising in the thyroid and propose a potential close relationship to *ETV6*-*NTRK3* fusion papillary thyroid carcinoma. The patient, a 36 year old woman, presented with a neck mass of 1 year’s duration. Imaging studies showed a tumor involving most of the thyroid with enlarged regional lymph nodes. FNA biopsy yielded a diagnosis of “papillary thyroid carcinoma”. Resection revealed a 4.5 cm infiltrative tumor. Final diagnosis was “papillary thyroid carcinoma (PTC) consistent with di... περισσότερα »
Pseudoaneurysm of an aberrant internal carotid artery in the middle ear caused by myringotomy
Pseudoaneurysm of an aberrant internal carotid artery in the middle ear caused by myringotomy: Abstract An aberrant internal carotid artery (ICA) is a rare abnormality associated with life-threatening otorrhagia if inadvertently injured during middle-ear surgery including myringotomy. We present a case where a 3-year-old girl experienced massive otorrhagia following myringotomy, and computed tomographic scan showed the aberrant ICA. Bleeding was controlled by ear canal packing, but rebleeding occurred. Investigations by carotid angiography demonstrated a pseudoaneurysm of the ab...περισσότερα »
Human papillomavirus in oral cavity and oropharynx carcinomas
in the central region of Brazil via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 9 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Guilherme Petito, Megmar Aparecida dos Santos Carneiro, Sílvia Helena de Rabello Santos, Antonio Marcio Teodoro Cordeiro Silva, Rita de Cassia Alencar, Antonio Paulo Gontijo, Vera Aparecida Saddi IntroductionMolecular studies about carcinomas of the oral cavity and oropharynx demonstrate the presence of human papilomavirus genome in these tumors, reinforcing the participation ...περισσότερα »
Cavernous hemangioma in the pterygopalatine fossa
*Cavernous hemangioma in unusual location: pterygopalatine fossa* *via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology* *Publication date: Available online 13 April 2016Source:Brazilian Journal of OtorhinolaryngologyAuthor(s): Bayram Şahin, Said Sönmez, Emine Dilek Yılmazbayhan, Kadir Serkan Orhan* Introduction *Hemangiomas are a benign vascular tumor and the most common benign tumors of the head and neck region. Although they usually present at birth or arise early in life, most of them involute spontaneously before adulthood. However, typically these tumors are ... περισσότερα »
Bilateral inferior concha bullosa connecting to maxillary sinus
*A case of * *via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology* *Publication date: Available online 11 April 2016Source:Brazilian Journal of OtorhinolaryngologyAuthor(s): Soo Kweon Koo, Ji Seung Moon, Sung Hoon Jung, Mi Jin Mun* Introduction *Nasal turbinates are important structures for the maintenance of normal nasal functions including humidification, filtration, lubrication, and thermoregulation of air inhaled through the nose arising from the lateral nasal wall. In general, individuals have three turbinates located at each side of the nasal cavity (superi... περισσότερα »
Caregivers
Quality of life impairment in patients with head and neck cancer and their caregivers: a comparative study via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 11 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Laís Rigoni, Raphaella Falco Bruhn, Rafael De Cicco, Jossi Ledo Kanda, Leandro Luongo de Matos IntroductionHead and neck cancer represents 3% of all the types of malignant neoplasms and squamous cell carcinoma (SCC) is responsible for 90% of these cases. There have been some studies evaluating the quali...περισσότερα »
Management of hyperacusis in children
* – two case reports* *via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology* *Publication date: Available online 11 April 2016Source:Brazilian Journal of OtorhinolaryngologyAuthor(s): Tanit Ganz Sanchez, Isabella Marques Pereira* Introduction *Hyperacusis is known as an abnormal reduced tolerance to environmental sounds.1 Such patients describe that everyday sounds are too loud and cause them discomfort or even pain.* *This medical condition may induce a strong impact on the quality of life because subjects usually avoid common situations, such as social, familiar ...περισσότερα »
Transient ischemic attack: an unusual presentation of a carotid body tumor
*Transient ischemic attack: an unusual presentation of a carotid body tumor* *via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology* *Publication date: Available online 13 April 2016Source:Brazilian Journal of OtorhinolaryngologyAuthor(s): Mojtaba Maleki, Mahdi Safdarian, Ali Daneshvar* Introduction *Carotid body tumors (CBTs) are the most common paragangliomas, with an incidence of one in every 30,000 people in the general population.1* *They usually affect middle-aged patients with chronic hypoxia and present as a cervical mass with lower cranial nerve palsies. CBT... περισσότερα »
Genomic Alterations of Anaplastic Thyroid Carcinoma Detected by Targeted Massive Parallel Sequencing in a BRAFV600E Mutation-Prevalent Area
Genomic Alterations of Anaplastic Thyroid Carcinoma Detected by Targeted Massive Parallel Sequencing in a BRAFV600E Mutation-Prevalent Area: Thyroid , Vol. 0, No. 0. Author information Min Ji Jeon,1* Sung-Min Chun,2* Deokhoon Kim,3 Hyemi Kwon,1 Eun Kyung Jang,1 † Tae Yong Kim,1 Won Bae Kim,1 Young Kee Shong,1 Se Jin Jang,2 Dong Eun Song ,2 and Won Gu Kim1 1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 2Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 3Center for Cancer ... περισσότερα »
The auditory feature found after the cancer treatment was a symmetrical bilateral sensorineural hearing loss. Chemotherapy with cisplatin proved to be a risk factor, while head and neck radiotherapy was not critical for the occurrence of hearing loss.
Audiological profile of patients treated for childhood cancer via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 13 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Patricia Helena Pecora Liberman, Maria Valéria Schmidt Goffi-Gomez, Christiane Schultz, Paulo Eduardo Novaes, Luiz Fernando Lopes ObjectiveTo characterize the hearing loss after cancer treatment, according to the type of treatment, with identification of predictive factors.MethodsTwo hundred patients who had cancer in childhood were prospectively ... περισσότερα »
Optimal timing of saliva collection to detect pepsin in patients with laryngopharyngeal reflux
Optimal timing of saliva collection to detect pepsin in patients with laryngopharyngeal reflux: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis To determine salivary pepsin levels as a function of collection time. Study Design A prospective, case-control study. Methods We selected 57 patients with clinical symptoms and signs of laryngopharyngeal reflux who underwent 24-hour multichannel intraluminal impedance-pH (24h MII-pH) monitoring tests, and 12 control subjects without clinical symptoms and signs of laryngopharyngeal reflux. All subjects were instruct... περισσότερα »
The effect of anchors on reliability of endoscopic tremor ratings
The effect of anchors on reliability of endoscopic tremor ratings: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis The purpose of this study was to determine the effects of anchors and training on intrarater and inter-rater reliability for visual-perceptual, endoscopic tremor ratings. Study Design Prospective cohort study. Methods Nasoendoscopy recordings of 10 participants with a diagnosis of essential voice tremor were evaluated by five voice specialists using the Vocal Tremor Scoring System. Ratings were performed before, immediately after, and 4 weeks ... περισσότερα »
Complication rates of open surgical versus percutaneous tracheostomy in critically ill patients
Complication rates of open surgical versus percutaneous tracheostomy in critically ill patients: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Background In the setting of critical care, the most common indications for tracheostomy include: prolonged intubation, to facilitate weaning from mechanical ventilation, and for pulmonary toileting. In this setting, tracheostomy can be performed either via open surgical or percutaneous technique. Advantages for percutaneous dilatational tracheostomy (PDT) include: simplicity, smaller incision, less tissue trauma, lower incidence of ... περισσότερα »
Effect of low frequency on speech performance with bimodal hearing in bilateral severe hearing loss
Effect of low frequency on speech performance with bimodal hearing in bilateral severe hearing loss: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis Unilateral cochlear implantation has emerged as a widely accepted procedure to treat severe to profound hearing loss, but many studies have reported benefits in terms of speech comprehension when listeners with residual low-frequency hearing in the nonimplanted ear use a hearing aid. Study Design Retrospective study. Methods In this study, we analyzed the speech performance and satisfaction of bimodal hearing ...περισσότερα »
Supramaximal neurostimulation with laryngeal palpation to predict postoperative vocal fold mobility
Supramaximal neurostimulation with laryngeal palpation to predict postoperative vocal fold mobility: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis Recurrent laryngeal nerve (RLN) injury during thyroidectomy or parathyroidectomy is a challenging issue and causes significant morbidity. We adopted the supramaximal stimulation protocol for neurostimulation with laryngeal palpation (NSLP) and tried to evaluate the predictive values of supramaximal NSLP for immediate postoperative vocal fold (VF) mobility. Study Design Prospective cohort study. Methods Prospec... περισσότερα »
NBI improves observer reliability in evaluation of upper aerodigestive tract lesions
Narrow band imaging improves observer reliability in evaluation of upper aerodigestive tract lesions: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis Visualization by endoscopy is essential in the diagnosis of upper aerodigestive tract lesions. Recent studies showed that narrow band imaging (NBI) increases the diagnostic potential of conventional white light imaging (WLI) by highlighting the superficial vessels. The objective of this study was to evaluate whether the use of NBI would influence inter- and intraobserver agreement while making diagnostic dec... περισσότερα »
Juvenile recurrent respiratory papillomatosis
10-year audit and Australian prevalence estimates: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis To estimate the prevalence of juvenile onset recurrent respiratory papillomatosis (RRP) in Australia, describe its epidemiological profile, and assess the positive predictive value of International Classification of Disease, 10th revision (ICD-10) code D14.1 (benign neoplasm of larynx) in children for hospitalization due to RRP. Study Design Retrospective case series. Methods Retrospective case review undertaken at the three tertiary pediatric hospitals in Ne... περισσότερα »
Lipofilling in post-treatment oropharyngeal dysfunction
Feasibility and potential value of [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis Head and neck cancer (HNC) patients may develop oropharyngeal dysfunction as result of volume loss or muscle atrophy of the tongue or pharyngeal musculature following treatment with surgery and/or chemoradiotherapy. If intensive swallowing therapy offers no further improvement, and the functional problems persist, transplantation of autologous adipose tissue (lipofilling) might restore functional outcomes by compensating the existing tissue defects or tissue loss. Study Des... περισσότερα »
Comparing nasal blood sampling and venipuncture for the assessment of hemoglobin levels and International normalized ratio (INR)
A prospective pilot study Objectives/Hypothesis This study is a pilot study evaluating the feasibility of sampling nose blood during an emergency using a commercially available rapid test device. It also compares the accuracy of rapid nasal blood test results to the results of standard laboratory methods using venous blood sampling. Methods Nose blood was collected in patients suffering from active epistaxis. In an emergency setting, hemoglobin levels and the international normalized ratio (INR) were assessed using a rapid point-of-care test device. These results were compared to st... περισσότερα »
Antibiotic prescription for acute rhinosinusitis
Emergency departments versus primary care providers: Objectives/Hypothesis We have previously identified patient characteristics associated with emergency department (ED) rather than primary-care provider (PCP) presentation for uncomplicated acute rhinosinusitis (ARS). Here we investigate potential disparities in prescription of antibiotics for patients presenting to a PCP versus ED for uncomplicated ARS. Study Design Cross-sectional study of the 2005 to 2010 National Ambulatory Medical Care Surveys and National Hospital Ambulatory Medical Care Surveys. Methods A total of 37,975,715... περισσότερα »
Mapping the plateau of novices in virtual reality simulation training of mastoidectomy
Mapping the plateau of novices in virtual reality simulation training of mastoidectomy: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis To explore why novices' performance plateau in directed, self-regulated virtual reality (VR) simulation training and how performance can be improved. Study Design Prospective study. Methods Data on the performances of 40 novices who had completed repeated, directed, self-regulated VR simulation training of mastoidectomy were included. Data were analyzed to identify key areas of difficulty as well as the procedures termina... περισσότερα »
Mondini dysplasia, also known as Mondini malformation and Mondini defect, is an abnormality of the inner ear that is associated with sensorineural hearing loss.
Mondini dysplasia From Wikipedia, the free encyclopedia *Mondini dysplasia*, also known as *Mondini malformation* and *Mondini defect*, is an abnormality of the inner ear that is associated with sensorineural hearing loss. This deformity was first described in 1791 by Carlo Mondini after examining the inner ear of a deaf boy. The Mondini dysplasia describes a cochlea with incomplete partitioning and a reduced number of turns, an enlarged vestibular aqueduct and a dilated vestibule. A normal cochlea has two and a half turns, a cochlea with Mondini dysplasia has one and a half turns; t... περισσότερα »
Peripheral vestibular pathology in Mondini dysplasia
Peripheral vestibular pathology in Mondini dysplasia: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis In this study, our objective was to histopathologically analyze the peripheral vestibular system in patients with Mondini dysplasia. Study Design Comparative human temporal bone study. Methods We assessed the sensory epithelium of the human vestibular system with a focus on the number of type I and type II hair cells, as well as the total number of hair cells. We compared those numbers in our Mondini dysplasia group versus our control group. Results The los... περισσότερα »
Impact of cochlear implantation on quality of life and mental comorbidity in patients aged 80 years
Impact of cochlear implantation on quality of life and mental comorbidity in patients aged 80 years: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis The objective of this study was to evaluate the outcome of cochlear implantation in elderly patients (80 or older) with progressive bilateral deafening. The measured outcomes included the quality of life, speech understanding, tinnitus distress, stress level, anxiety, and depressiveness. Study Design Prospective cohort study. Methods Seventeen 80+ years (mean 82.9 ± 2.7 years) patients with progressive, postli... περισσότερα »
Impact of a mentored student clerkship on underrepresented minority diversity in otolaryngology-head and neck surgery
Impact of a mentored student clerkship on underrepresented minority diversity in otolaryngology-head and neck surgery: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis To describe the impact of a mentored clerkship initiative on underrepresented minority medical students interested in otolaryngology–head and neck surgery (OHNS). Study Design Prospective observational study. Methods An outreach effort to recruit underrepresented minority students was initiated in 2008, consisting of either a 3-month research clerkship or a 1-month clinical rotation. Financia... περισσότερα »
Recognizing a cervical origin of the right subclavian artery
The importance of [image: cover.gif?v=1&s=634ce17de2958347d854769c] Cervical origin of the right subclavian artery is rare and is associated with DiGeorge syndrome. During total thyroidectomy and right lateral neck dissection for metastatic thyroid cancer in a 26-year-old female, the right subclavian artery was found to be cervical in origin. This was identifiable on preoperative computerized tomography. Screening for DiGeorge syndrome and other cardiovascular abnormalities in this patient was negative. However, all reported cases of this right subclavian artery anomaly tested p... περισσότερα »
Optimal bovine collagen concentration to achieve tracheal epithelial coverage of collagen sponges
Optimal bovine collagen concentration to achieve tracheal epithelial coverage of collagen sponges: [image: cover.gif?v=1&s=634ce17de2958347d854769c] Objectives/Hypothesis Artificial tracheas prepared using a collagen sponge and polypropylene mesh have been implanted in patients who received tracheal resections, but epithelialization in the reconstructed area is slow. We determined the optimal bovine atelocollagen concentration necessary for the rapid and complete tracheal epithelial coverage of collagen sponge implants. Study Design Preliminary animal experiment. Methods Collagen... περισσότερα »
Guided bone regeneration in standardized calvarial defects
using beta-tricalcium phosphate and collagen membrane: a real-time in vivo micro-computed tomographic experiment in rats: AbstractGuided bone regeneration (GBR) procedures using graft materials have been used for reconstruction of osseous defects. The aim of the present in vivo micro-computed tomographic (µCT) and histologic study was to assess in real time the bone regeneration at GBR sites in standardized experimental calvarial defects (diameter 3.3 mm) using β-tricalcium phosphate (β-TCP) with and without collagen membrane (CM). A single full-thickness calvarial defect was crea...περισσότερα »
Novel bioinformatic developments for exome sequencing
Abstract With the widespread adoption of next generation sequencing technologies by the genetics community and the rapid decrease in costs per base, exome sequencing has become a standard within the repertoire of genetic experiments for both research and diagnostics. Although bioinformatics now offers standard solutions for the analysis of exome sequencing data, many challenges still remain; especially the increasing scale at which exome data are now being generated has given rise to novel challenges in how to efficiently store, analyze and interpret exome data of this magnitude. I... περισσότερα »
Assessing the genetic architecture of epithelial ovarian cancer histological subtypes
Abstract Epithelial ovarian cancer (EOC) is one of the deadliest common cancers. The five most common types of disease are high-grade and low-grade serous, endometrioid, mucinous and clear cell carcinoma. Each of these subtypes present distinct molecular pathogeneses and sensitivities to treatments. Recent studies show that certain genetic variants confer susceptibility to all subtypes while other variants are subtype-specific. Here, we perform an extensive analysis of the genetic architecture of EOC subtypes. To this end, we used data of 10,014 invasive EOC patients and 21,233 con... περισσότερα »
Hangeshashinto on calprotectin expression in human oral epithelial cells
Effect of AbstractOral epithelial cells produce antimicrobial peptides (AMPs) to prevent microbial infection. Calprotectin (S100A8/S100A9) is one of these AMPs in oral epithelial cells, the expression of which is up-regulated by interleukin-1α (IL-1α). Hangeshashinto (HST) is a traditional Japanese herbal medicine that has anti-inflammatory effects. The purpose of this study was to investigate the effect of HST on the expression of calprotectin through the regulation of IL-1α in oral epithelial cells. Human oral epithelial cells (TR146) were cultured with HST in the presence or ... περισσότερα »
Application of the transtheoretical model of behaviour change for identifying older clients’ readiness for hearing rehabilitation during history-taking in audiology appointments
Application of the transtheoretical model of behaviour change for identifying older clients’ readiness for hearing rehabilitation during history-taking in audiology appointments: 10.3109/14992027.2015.1136080<br>Katie Ekberg Abstract *Objectives*: The transtheoretical model (TTM) of behaviour change focuses on clients’ readiness for adopting new health behaviours. This study explores how clients’ readiness for change can be identified through their interactions with audiologists during history-taking in initial appointments; and whether clients’ readiness has consequences for th... περισσότερα »
Effects of language experience on pre-categorical perception
Distinguishing general from specialized processes in speech perception: [image: cm_sbs_024_plain.png] Cross-language differences in speech perception have traditionally been linked to phonological categories, but it has become increasingly clear that language experience has effects beginning at early stages of perception, which blurs the accepted distinctions between general and speech-specific processing. The present experiments explored this distinction by playing stimuli to English and Japanese speakers that manipulated the acoustic form of English /r/ and /l/, in order to dete... περισσότερα »
On the variation of interaural time differences with frequency
On the variation of interaural time differences with frequency: [image: cm_sbs_024_plain.png] Interaural time difference(ITD) is a major cue to sound localization in humans and animals. For a given subject and position in space, ITD depends on frequency. This variation is analyzed here using a head related transfer functions (HRTFs) database collected from the literature and comprising human HRTFs from 130 subjects and animal HRTFs from six specimens of different species. For humans, the ITD is found to vary with frequency in a way that shows consistent differences with respect to ... περισσότερα »
Benefit of pediatric cochlear implantation before 12 months of age
A Systematic Review to Define the Speech and Language Benefit of Early (: *Objective:* This review aimed to evaluate the additional benefit of pediatric cochlear implantation before 12 months of age considering improved speech and language development and auditory performance. *Materials and Methods:* We conducted a search in PubMed, EMBASE and CINAHL databases and included studies comparing groups with different ages at implantation and assessing speech perception and speech production, receptive language and/or auditory performance. We included studies with a high directness of ev... περισσότερα »
Video Feedback in Key Word Signing Training for Preservice Direct Support Staff
Video Feedback in Key Word Signing Training for Preservice Direct Support Staff: Purpose Research has demonstrated that formal training is essential for professionals to learn key word signing. Yet, the particular didactic strategies have not been studied. Therefore, this study compared the effectiveness of verbal and video feedback in a key word signing training for future direct support staff. Method Forty-nine future direct support staff were randomly assigned to 1 of 3 key word signing training programs: modeling and verbal feedback (classical method [CM]), additional video f... περισσότερα »
KinectOne to quantify kinematics of the upper body
Accuracy of via Gait & Posture Publication date: Available online 13 April 2016 *Source:*Gait & Posture Author(s): Roman P. Kuster, Bernd Heinlein, Christoph M. Bauer, Eveline S. Graf Motion analysis systems deliver quantitative information, e.g. on the progress of rehabilitation programs aimed at improving range of motion. Markerless systems are of interest for clinical application because they are low-cost and easy to use. The first generation of the Kinect™ sensor showed promising results in validity assessment compared to an established marker-based system. However, no literature... περισσότερα »
Tonal frequency affects amplitude but not topography of cranial EEG components
rhesus monkey via Hearing Research Publication date: Available online 13 April 2016 *Source:*Hearing Research Author(s): Tobias Teichert The rhesus monkey is an important model of human auditory function in general and auditory deficits in neuro-psychiatric diseases such as schizophrenia in particular. Several rhesus monkey studies have described homologs of clinically relevant auditory evoked potentials such as pitch-based mismatch negativity, a fronto-central negativity that can be observed when a series of regularly repeating sounds is disrupted by a sound of different tonal freq... περισσότερα »
Visual information to the perception of speech in noise
The contribution of visual information to the perception of speech in noise with and without informative temporal fine structure via Hearing Research Publication date: Available online 13 April 2016 *Source:*Hearing Research Author(s): Paula C. Stacey, Pádraig T. Kitterick, Saffron D. Morris, Christian J. Sumner Understanding what is said in demanding listening situations is assisted greatly by looking at the face of a talker. Previous studies have observed that normal-hearing listeners can benefit from this visual information when a talker’s voice is presented in background noise. Th... περισσότερα »
Meat intake and non-Hodgkin lymphoma: a meta-analysis of observational studies
Abstract Purpose High intake of meat has been inconsistently associated with increased risk of non-Hodgkin lymphoma (NHL). We carried out a meta-analysis to summarize the evidence of published observational studies reporting association between red meat and processed meat intake and NHL risk. Methods Analytical studies reporting relative risks with 95 % confidence intervals (95 %… Continue reading Meat intake and non-Hodgkin lymphoma: a meta-analysis of observational studies
A subtype of thyroid tumor isn’t cancer, Pitt experts find – Pittsburgh Post-Gazette
A subtype of thyroid tumor isn’t cancer, Pitt experts find Pittsburgh Post-Gazette People diagnosed with a particular type of thyroid cancer and aggressively treated for it actually didn’t have cancer after all. That’s the conclusion of 24 endocrinology pathologists from seven countries empaneled by the University of Pittsburgh … from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader… Continue reading A subtype of thyroid tumor isn’t cancer, Pitt experts find – Pittsburgh Post-Gazette
In Vivo Bone Formation Within Engineered Hydroxyapatite Scaffolds in a Sheep Model
Abstract Large bone defects still represent a major burden in orthopedics, requiring bone-graft implantation to promote the bone repair. Along with autografts that currently represent the gold standard for complicated fracture repair, the bone tissue engineering offers a promising alternative strategy combining bone-graft substitutes with osteoprogenitor cells able to support the bone tissue ingrowth within… Continue reading In Vivo Bone Formation Within Engineered Hydroxyapatite Scaffolds in a Sheep Model
Screen time is associated with depressive symptomatology among obese adolescents: a HEARTY study
Abstract Obese adolescents spend a disproportionate time in screen-based activities and are at higher risk for clinical depression compared to their normal-weight peers. While screen time is associated with obesity and cardiometabolic risk factors, little is known about the relationship between screen time and mental health. This cross-sectional study examines the association between duration and… Continue reading Screen time is associated with depressive symptomatology among obese adolescents: a HEARTY study
Fig 2. Human Auditory System
The Central Nervous System (CNS) = brain and spinal cord. The auditory system is the sensory system for the sense of hearing. The sound waves … from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SbF0Ba via IFTTT
Evaluation of Serum Creatinine Changes With Integrase Inhibitor Use in Human Immunodeficiency Virus-1 Infected Adults
This retrospective chart review evaluated changes in serum creatinine and creatinine clearance (CrCl) after initiation of an integrase inhibitor (INSTI)-based regimen as initial treatment in human immunodeficiency virus-infected adults. Serum creatinine and CrCl changes were similar to those seen in clinical trials for INSTIs. No renal-related serious adverse events or discontinuations occurred. from #ORL-AlexandrosSfakianakis via… Continue reading Evaluation of Serum Creatinine Changes With Integrase Inhibitor Use in Human Immunodeficiency Virus-1 Infected Adults
The Implications of Low Absolute CD4 Counts in Patients With Cirrhosis and Human Immunodeficiency Virus
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1XwNYu1 via IFTTT
Pre- and post-conditioning hormesis in elderly mice, rats, and humans: its loss and restoration
Abstract This paper assessed differences and similarities in the capacity for preconditioning (PC) and post-conditioning (PostC) to prevent ischemic reperfusion (IR) damage to the heart in the old/elderly as compared to young adult mice, rats, and humans. While PC reliably reduces myocardial ischemia-induced heart damage by about 30–60 % in young adult (2–3 months old)… Continue reading Pre- and post-conditioning hormesis in elderly mice, rats, and humans: its loss and restoration
Ist beim diffus großzelligen B‑Zell-Lymphom im frühen Stadium nach der Chemotherapie eine konsolidieren de Strahlentherapie erforderlich?
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/261a8dH via IFTTT
MLB Unveils 300 New Looks as 2016 Specialty Uniforms Released – SportsLogos.Net News
MLB Unveils 300 New Looks as 2016 Specialty Uniforms Released SportsLogos.Net News Proceeds from the sales of the holiday jerseys will be donated to various cancer and veteran charities (the details of which will be provided in each holidays section below. We’ll present …. They needed to take a throat culture to see if I… Continue reading MLB Unveils 300 New Looks as 2016 Specialty Uniforms Released – SportsLogos.Net News
Mediation of Racial and Ethnic Disparities in Estrogen/Progesterone Receptor-Negative Breast Cancer by Socioeconomic Position and Reproductive Factors
Hispanic and non-Hispanic black breast cancer patients are more likely than non-Hispanic white patients to be diagnosed with breast cancer that is negative for estrogen and progesterone receptors (ER/PR-negative). This disparity might be transmitted through socioeconomic and reproductive factors. Data on 746 recently diagnosed breast cancer patients (300 non-Hispanic white, 303 non-Hispanic black, 143 Hispanic) were obtained from the population-based Breast Cancer Care in Chicago Study (Chicago, Illinois, 2005–2008). Income, educational level, and census tract measures of concentr...περισσότερα »
MEDIATION ANALYSIS WITH MATCHED CASE-CONTROL STUDY DESIGNS
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Is there a role for a bespoke app on antimicrobial stewardship targeting patients and the public?
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Transmission of Hepatitis B core Antibody and Galactomannan Enzyme Immunoassay positivity via immunoglobulin products: a comprehensive analysis
Therapeutic immunoglobulins can transmit clinically important antibodies, including those directed against Hepatitis B virus (HBV), and antigens producing false-positive results for galactomannan EIA. We demonstrate that immunoglobulin administration commonly leads to positive HBV core antibody and galactomannan but is product-dependent. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/23GGt7I via IFTTT
Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: Available online 13 April 2016 Source:European Journal of Cancer Author(s): Lars Hofmann, Andrea Forschner, Carmen Loquai, Simone M. Goldinger, Lisa Zimmer, Selma Ugurel, Maria I. Schmidgen, Ralf Gutzmer, Jochen S. Utikal, Daniela Göppner, Jessica C. Hassel, Friedegund Meier, Julia K. Tietze, Ioannis Thomas, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, […]
Toenail selenium status and risk of subtypes of head-neck cancer: The Netherlands Cohort Study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: June 2016 Source:European Journal of Cancer, Volume 60 Author(s): Denise H.E. Maasland, Leo J. Schouten, Bernd Kremer, Piet A. van den Brandt BackgroundThere is limited prospective data on the relationship between selenium status and the risk of head-neck cancer (HNC) and HNC subtypes (i.e., oral cavity cancer [OCC], oro-/hypopharyngeal cancer [OHPC] and laryngeal […]
Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: Available online 13 April 2016 Source:European Journal of Cancer Author(s): Lisa Zimmer, Simone M. Goldinger, Lars Hofmann, Carmen Loquai, Selma Ugurel, Ioannis Thomas, Maria I. Schmidgen, Ralf Gutzmer, Jochen S. Utikal, Daniela Göppner, Jessica C. Hassel, Friedegund Meier, Julia K. Tietze, Andrea Forschner, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, […]
Reproducibility of Contrast-Enhanced Ultrasound in Mice with Controlled Injection
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Abstract Purpose Sensitivity of contrast-enhanced ultrasound (CEUS) to microvascular flow modifications can be limited by intra-injection variability (injected dose, rate, volume). Procedures To evaluate the effect of injection variability on microvascular flow evaluation, CEUS was compared between controlled and manual injections where enhancement was assessed in vitro within a flow phantom, in normal murine kidney […]
Comparative Study of Tumor Targeting and Biodistribution of pH (Low) Insertion Peptides (pHLIP ® Peptides) Conjugated with Different Fluorescent Dyes
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Abstract Purpose Acidification of extracellular space promotes tumor development, progression, and invasiveness. pH (low) insertion peptides (pHLIP® peptides) belong to the class of pH-sensitive membrane peptides, which target acidic tumors and deliver imaging and/or therapeutic agents to cancer cells within tumors. Procedures Ex vivo fluorescent imaging of tissue and organs collected at various time points […]
Effects of antioxidant system on coronary artery lesions in patients with abnormal glucose metabolism
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Abstract Objective To evaluate the effects of catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) system on the range and severity of coronary artery lesions in patients with abnormal glucose metabolism. Methods This study included 766 patients with abnormal glucose metabolism. Levels of fasting blood lipids, blood glucose, CAT, SOD, GSH, glutathione reductase (GR), and […]
A matter of dispersal: REVEALSinR introduces state-of-the-art dispersal models to quantitative vegetation reconstruction
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Abstract The REVEALS model is applied in quantitative vegetation reconstruction to translate pollen percentage data from large lakes and peatlands into regional vegetation composition. The model was first presented in 2007 and has gained increasing attention. It is a core element of the Landcover 6k initiative within the PAGES project. The REVEALS model has two […]
Adhesion molecules in peritoneal dissemination: function, prognostic relevance and therapeutic options
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Abstract Peritoneal dissemination is diagnosed in 10–25 % of colorectal cancer patients. Selected patients are treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. For these patients, earlier diagnosis, optimised selection criteria and a personalised approach are warranted. Biomarkers could play a crucial role here. However, little is known about possible candidates. Considering tumour cell adhesion […]
New Insights into Old Waves. Matching Stimulus- and Response-Locked ERPs on the Same Time-Window
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: Available online 13 April 2016 Source:Biological Psychology Author(s): M. Berchicci, D. Spinelli, F.Di Russo We compared the effect of locking the event-related potentials (ERPs) on the stimulus vs. the response in a simple (SRT) and in a discriminative (DRT, equally probable Go/No-go) visuo-motor task. The accurate alignment of stimulus- and response-locked ERPs on […]
Determinants of altered intracellular endocrine-immune interplay in Bosnian war refugees suffering from PTSD
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: Available online 13 April 2016 Source:Biological Psychology Author(s): Kenneth P. Pitts, Ljiljana Joksimovic, Susann Steudte-Schmiedgen, Nicolas Rohleder, Jutta M. Wolf Posttraumatic Stress Disorder (PTSD) has been repeatedly linked to changes in glucocorticoid (GC) sensitivity. To increase our understanding of this phenomenon and its potential relevance for PTSD development and treatment, the current study […]
Evaluation of Serum Creatinine Changes With Integrase Inhibitor Use in Human Immunodeficiency Virus-1 Infected Adults
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
This retrospective chart review evaluated changes in serum creatinine and creatinine clearance (CrCl) after initiation of an integrase inhibitor (INSTI)-based regimen as initial treatment in human immunodeficiency virus-infected adults. Serum creatinine and CrCl changes were similar to those seen in clinical trials for INSTIs. No renal-related serious adverse events or discontinuations occurred. from Infectious Diseases […]
The Implications of Low Absolute CD4 Counts in Patients With Cirrhosis and Human Immunodeficiency Virus
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
from Infectious Diseases via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XwNYu1 via IFTTT
Microcephaly, dysmorphic features, corneal dystrophy, hairy nipples, underdeveloped labioscrotal folds, and small cerebellum in four patients
Pontocerebellar hypoplasia (PCH) can occur as an isolated entity or part of a syndrome. PCH has been reported with facial dysmorphism, ocular anomalies, and genital anomalies, but the co-occurrence of all four has not been previously described. We report on four patients, born to two consanguineous families that are not related to one another, with distinctive facial features (short forehead, laterally extended, medially flared eyebrows), corneal dystrophy, underdevelopment of labioscrotal folds, and nonprogressive PCH. In addition, the patients show hair extruding from the lacti... περισσότερα »
Novel splicing mutation in the ASXL3 gene causing Bainbridge–Ropers syndrome
Bainbridge–Ropers syndrome (BRPS) is characterized by severe developmental delay, feeding problems, short stature, characteristic facal appearance including arched eyebrows and anteverted nares, and ulnar deviation of the hands. BRPS is caused by a heterozygous mutation in the *additional sex combs-like 3* (*ASXL3*) gene. We describe a patient with severe developmental delay, feeding problems, short stature, autism, and sleep disturbance with a heterozygous de novo splicing mutation in the *ASXL3* gene. Reported disease-causing mutations in *ASXL3* are located mostly in the first...περισσότερα »
Genomic Alterations of Anaplastic Thyroid Carcinoma Detected by Targeted Massive Parallel Sequencing in a BRAFV600E Mutation-Prevalent Area
Thyroid , Vol. 0, No. 0. from thyroid via a.lsfakia on Inoreader http://ift.tt/1VqWA8g via IFTTT
Lipopolysaccharide modification in Gram-negative bacteria during chronic infection
The Gram-negative bacterial lipopolysaccharide (LPS) is a major component of the outer membrane that plays a key role in host–pathogen interactions with the innate immune system. During infection, bacteria are exposed to a host environment that is typically dominated by inflammatory cells and soluble factors, including antibiotics, which provide cues about regulation of gene expression. Bacterial adaptive changes including modulation of LPS synthesis and structure are a conserved theme in infections, irrespective of the type or bacteria or the site of infection. In general, these c... περισσότερα »
Bilateral axillary and infrahilar nodal metastases in follicular variant of papillary thyroid carcinoma (transformed into poorly differentiated subtype) in the setting of elevated thyroglobulin and negative radioiodine scintigraphy
*Sandip Basu* Journal of Cancer Research and Therapeutics 2016 12(1):423-424 from thyroid via a.lsfakia on Inoreader http://ift.tt/1qIWID4 via IFTTT
Influence of repeat surgery on treatment time in the interdisciplinary management of impacted maxillary canines-A retrospective cohort study
To evaluate the effect of repeat surgery on treatment time in the interdisciplinary management of impacted maxillary canines. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1T58ocq via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Evaluation of two formulations containing mineral trioxide aggregate on delayed tooth replantation: relevance of RANKL/RANK/OPG system
Abstract This study aimed to evaluate the effects of White MTA (WMTA) and MTA Fillapex® on root resorption, when used for root canal filling, in a rat model of delayed tooth replantation, with special focus on the RANKL/RANK/OPG system. Maxillary right central incisors of male rats were extracted (total *N* = 48), and exposed to dry environment for 30 min. The animals were allocated into four groups: (1) WMTA; (2) MTA Fillapex; (3) Calcium hydroxide; (4) Negative control. After periodontal ligament removal, root canals were filled with the corresponding material and replanted. Aft... περισσότερα »
Effect of triple antibiotic paste with or without ethylenediaminetetraacetic acid on surface loss and surface roughness of radicular dentine
Abstract This study aimed to compare the effect of two concentrations of triple antibiotic paste (TAP) with or without ethylenediaminetetraacetic acid (EDTA) on surface loss and surface roughness of radicular dentine. Human radicular dentine specimens were randomized into six experimental groups ( *n* = 16 per group). The first and second groups were treated with 1,000 mg/mL or 1 mg/mL of TAP for 4 weeks. The third and fourth groups were treated with 1,000 mg/mL or 1 mg/mL of TAP for 4 weeks followed by 17 % EDTA for 5 min. The fifth group was treated with 17 % EDTA for 5 min and t...περισσότερα »
Isolation, characterization and investigation of differentiation potential of human periodontal ligament cells and dental follicle progenitor cells and their response to BMP-7 in vitro
Abstract The aim of this study was to assess the factors, mechanisms and the differences between periodontal ligament (PDL) cells and denta l follicle (DF) progenitor cells towards the osteoblastic/cementoblastic differentiation and to investigate the effects of BMP-7 on developmental (DF) and mature tissue-derived (PDL) cells, respectively. Primary cell culture of PDL cells and DF progenitor cells was performed. Osteogenic differentiation was evaluated using von Kossa, Alizarin Red S and immuno-histo-chemistry staining of osteocalcin. Gene expression pattern was evaluated via rea... περισσότερα »
Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy
Publication date: Available online 13 April 2016 *Source:*European Journal of Cancer Author(s): Lisa Zimmer, Simone M. Goldinger, Lars Hofmann, Carmen Loquai, Selma Ugurel, Ioannis Thomas, Maria I. Schmidgen, Ralf Gutzmer, Jochen S. Utikal, Daniela Göppner, Jessica C. Hassel, Friedegund Meier, Julia K. Tietze, Andrea Forschner, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, Michael C. Kirchberger, Thomas Eigentler, Carola Berking, Anja Gesierich, Angela M. Krackhardt, Dirk Schadendorf, Gerold Schuler, Reinhard Dummer, Lucie M. Heinzerling BackgroundAn... περισσότερα »
Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy
Publication date: Available online 13 April 2016 *Source:*European Journal of Cancer Author(s): Lars Hofmann, Andrea Forschner, Carmen Loquai, Simone M. Goldinger, Lisa Zimmer, Selma Ugurel, Maria I. Schmidgen, Ralf Gutzmer, Jochen S. Utikal, Daniela Göppner, Jessica C. Hassel, Friedegund Meier, Julia K. Tietze, Ioannis Thomas, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, Michael C. Kirchberger, Thomas Eigentler, Carola Berking, Anja Gesierich, Angela M. Krackhardt, Dirk Schadendorf, Gerold Schuler, Reinhard Dummer, Lucie M. Heinzerling BackgroundAn... περισσότερα »
Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy
Publication date: Available online 13 April 2016 *Source:*European Journal of Cancer Author(s): Lisa Zimmer, Simone M. Goldinger, Lars Hofmann, Carmen Loquai, Selma Ugurel, Ioannis Thomas, Maria I. Schmidgen, Ralf Gutzmer, Jochen S. Utikal, Daniela Göppner, Jessica C. Hassel, Friedegund Meier, Julia K. Tietze, Andrea Forschner, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, Michael C. Kirchberger, Thomas Eigentler, Carola Berking, Anja Gesierich, Angela M. Krackhardt, Dirk Schadendorf, Gerold Schuler, Reinhard Dummer, Lucie M. Heinzerling BackgroundAn... περισσότερα »
Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy
Publication date: Available online 13 April 2016 *Source:*European Journal of Cancer Author(s): Lars Hofmann, Andrea Forschner, Carmen Loquai, Simone M. Goldinger, Lisa Zimmer, Selma Ugurel, Maria I. Schmidgen, Ralf Gutzmer, Jochen S. Utikal, Daniela Göppner, Jessica C. Hassel, Friedegund Meier, Julia K. Tietze, Ioannis Thomas, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, Michael C. Kirchberger, Thomas Eigentler, Carola Berking, Anja Gesierich, Angela M. Krackhardt, Dirk Schadendorf, Gerold Schuler, Reinhard Dummer, Lucie M. Heinzerling BackgroundAn... περισσότερα »
Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy
Publication date: Available online 13 April 2016 *Source:*European Journal of Cancer Author(s): Lisa Zimmer, Simone M. Goldinger, Lars Hofmann, Carmen Loquai, Selma Ugurel, Ioannis Thomas, Maria I. Schmidgen, Ralf Gutzmer, Jochen S. Utikal, Daniela Göppner, Jessica C. Hassel, Friedegund Meier, Julia K. Tietze, Andrea Forschner, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, Michael C. Kirchberger, Thomas Eigentler, Carola Berking, Anja Gesierich, Angela M. Krackhardt, Dirk Schadendorf, Gerold Schuler, Reinhard Dummer, Lucie M. Heinzerling BackgroundAn... περισσότερα »
Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy
Publication date: Available online 13 April 2016 *Source:*European Journal of Cancer Author(s): Lars Hofmann, Andrea Forschner, Carmen Loquai, Simone M. Goldinger, Lisa Zimmer, Selma Ugurel, Maria I. Schmidgen, Ralf Gutzmer, Jochen S. Utikal, Daniela Göppner, Jessica C. Hassel, Friedegund Meier, Julia K. Tietze, Ioannis Thomas, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, Michael C. Kirchberger, Thomas Eigentler, Carola Berking, Anja Gesierich, Angela M. Krackhardt, Dirk Schadendorf, Gerold Schuler, Reinhard Dummer, Lucie M. Heinzerling BackgroundAn... περισσότερα »
Impact of Squamous Differentiation in Breast Carcinoma
This study attempted to review the impact of extent of squamous differentiation in 56 infiltrating duct carcinomas (IDC) with squamous differentiation (metaplastic squamous carcinomas [MSC]). Tumors showing 100% squamous elements were labeled as primary squamous carcinomas (PSC; n = 28) and compared with 28 MSC showing lesser squamous components. A clinicopathological comparison revealed that lymphovascular emboli were never seen in any PSC but were noted in 7/28 of other MSC, while perineural invasion was seen only in PSC and not in MSC. Nodal metastasis was significantly more in... περισσότερα »
Thyreoglossal Duct Cyst with Evidence of Solid Cell Nests and Atypical Thyroid Follicles
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RETRACTED ARTICLE: A variety of pesticides trigger in vitro α-synuclein accumulation, a key event in Parkinson’s disease
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1XwFp2p via IFTTT
miR-138-1* regulates aflatoxin B1-induced malignant transformation of BEAS-2B cells by targeting PDK1
Abstract Environmental carcinogens-induced lung cancer and potential mechanisms have attracted widespread attention. Currently, microRNAs (miRNAs) have been recognized as key players in development of cancer, among which guide strand of miRNA has been well documented rather than its passenger strand (miRNA*). Our previous study showed that treatment of 0.1 nM AFB1 for 50 passages could… Continue reading miR-138-1* regulates aflatoxin B1-induced malignant transformation of BEAS-2B cells by targeting PDK1
Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increa se in GSK-3β enzyme, β-amyloid and tau protein levels
Abstract Cadmium is a neurotoxic compound which induces cognitive alterations similar to those produced by Alzheimer’s disease (AD). However, the mechanism through which cadmium induces this effect remains unknown. In this regard, we described in a previous work that cadmium blocks cholinergic transmission and induces a more pronounced cell death on cholinergic neurons from basal… Continue reading Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increa se in GSK-3β enzyme, β-amyloid and tau protein levels
