Review of treatment modalities and outcomes of patients with basal cell adenocarcinoma: Publication date: Available online 6 February 2020Source: American Journal of OtolaryngologyAuthor(s): Claudia N. Gutierrez, Kyriakos Chatzopoulos, Joaquin J. Garcia, Jeffrey R. JanusAbstractPurposeThis study summarizes the treatment modalities of basal cell adenocarcinoma (BCAC) of the parotid gland and subsequent outcome at a single institution to better define the treatment of this rare tumor.Material and methodsA...
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The importance of sublingual gland removal in treatment of ranulas: A large retrospective study: Publication date: Available online 7 February 2020Source: American Journal of OtolaryngologyAuthor(s): Jeffrey K. Than, Tara Rosenberg, Grace Anand, Matthew SittonAbstractPurposeInvestigate the efficacy of sublingual gland removal for the treatment of simple and plunging ranulas.Materials and methodsAfter IRB approval, a retrospective review was performed on patients treated for a ranula from February...
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Predictors of occult lymph node metastases in lip cancer: Publication date: Available online 7 February 2020Source: American Journal of OtolaryngologyAuthor(s): Edward Walton, John CramerAbstractObjectiveThe incidence of lymph node metastases (LNM) in squamous cell carcinoma of the lip is modest (8%), making it challenging to identify patients that may benefit from elective pathologic staging evaluation of the neck. We evaluated predictors of LNM in patients with lip cancer in order to potentially...
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Securing the position of the nasoseptal flap in endoscopic transsphenoidal surgery: No need for a Foley catheter (technical report): Publication date: Available online 8 February 2020Source: American Journal of OtolaryngologyAuthor(s): Emad A.S. Massoud, Andrea L.O. Hebb, David B. ClarkeAbstractBackgroundThe pedicled nasoseptal mucoperiosteal flap is currently widely used for the reconstruction of a skull base defect following transsphenoidal surgery. The flap is generally secured in position by...
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Topical intranasal fluorescein to localize a cerebrospinal fluid leak: A demonstration: Publication date: Available online 11 February 2020Source: American Journal of OtolaryngologyAuthor(s): Jeremy Barr, Jason Ni, Johnathan McGinn, Neerav GoyalAbstractBackgroundIntrathecal fluorescein is commonly used to localize cerebrospinal fluid leaks. This technique is invasive and associated with several potential adverse effects. The purpose of this video presentation is to demonstrate an alternative technique,...
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Urinary paraben concentrations and their implications for human exposure in Iranian pregnant women: AbstractParabens are widely used as preservatives in cosmetics, medicines, and foods due to its antimicrobial properties. Concerns have been raised regarding the estrogenic activity and potential endocrine disruption effects of parabens. Studies on monitoring of paraben exposure in the Iranian population are very scarce. This study was carried out to measure urinary concentrations of parabens, to estimate...
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Oral antimicrobial activity weakened in children with electronic waste lead exposure: AbstractEnvironmental lead (Pb) exposure can induce dysbacteriosis, impair oral health, and is associated with the development of dental caries. However, the mechanism is unclear. The aim of this study was to explore the effects of Pb toxicity on oral antimicrobial activity in children in an e-waste area. Results showed higher blood Pb levels in e-waste-exposed group children, accompanied by decreased saliva SAG...
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A 31-year-old Micronesian Man With Shoulder Fungating Mass: A 31-year-old male, from the Island of Chuuk (Micronesia), presented to our service with a large fungating shoulder mass. The mass originated 1 year ago as a blister-like lesion at the site of a prior tattoo and slowly expanded to encompass most of the shoulder. The lesion was intermittently painful and without dysesthesia. He lived in Missouri for the past 8 years after emigrating from Guam at age 23. He previously worked in construction...
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The effect of ionizing radiation on properties of fluoride-releasing restorative materials: Abstract The purpose of this study was to evaluate the effect of ionizing radiation from high energy X-ray on fluoride release, surface roughness, flexural strength, and surface chemical composition of the materials. The study groups comprised five different restorative materials: Beautifil II, GCP Glass Fill, Amalgomer CR, Zirconomer, and Fuji IX GP. Twenty disk-shaped specimens (8x2 mm) for fluoride release...
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Esthetic perception of facial profile changes after extraction and nonextraction Class II treatment: Abstract This retrospective study evaluated facial profile pleasantness determined by two protocols of Class II treatment. The sample comprised facial profile silhouettes obtained retrospectively from the pretreatment (T1) and posttreatment (T2) cephalograms of 60 patients (42 males and 18 females) divided into two groups. One group of 30 patients (mean age of 12.84 years) was treated with the extraction...
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Dental caries experience and associated factors in 12-year-old-children: a population based-study: Abstract Relevant public policies in oral health have been implemented in Brazil since 2004. Changes in the epidemiological status of dental caries are expected, mainly in the child population. This study aimed to assess the dental caries experience and associated factors among 12-year-old children in the state of São Paulo, Brazil. A cross-sectional population-based study was conducted with data obtained...
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Trigger factors in migraine with aura: The aim of the present study was to identify trigger factors in migraine with aura (MA). A total of 629 MA patients representative of the Danish population were sent a questionnaire listing 16 trigger factors thought to be relevant as well as space for free text. Distinction was made between attacks with or without aura within each patient. The questionnaire was returned by 522 patients of whom 347 had current MA attacks. In total 80% with current attacks (278/347)...
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Central mechanisms of stress‐induced headache: Stress is the most commonly reported trigger of an episode of chronic tension‐type headache (CTTH); however, the causal significance has not been experimentally demonstrated to date. Stress may trigger CTTH through hyperalgesic effects on already sensitized pain pathways in CTTH sufferers. This hypothesis could be partially tested by examining pain sensitivity in an experimental model of stress‐induced headache in CTTH sufferers. Such examinations have...
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Abnormal brain processing of pain in migraine without aura: a high‐density EEG brain mapping study: In the present study we used high‐density EEG brain mapping to investigate spatio‐temporal aspects of brain activity in response to experimentally induced muscle pain in 17 patients with migraine without aura and 15 healthy controls. Painful electrical stimuli were applied to the trapezius muscle and somatosensory‐evoked potentials were recorded with 128‐channel EEG with and without concurrent induced...
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Early treatment of acute migraine: new evidence of benefits: Valade D. Early treatment of acute migraine: new evidence of benefits. Cephalalgia 2009; 29 (Suppl. 3):15–21. London. ISSN 0333‐1024The current management approach to migraine headaches advocates use of triptan medications early in the course of an attack while pain is still mild, rather than waiting to treat the pain when it has progressed to moderate–severe. Recently, strong new evidence for the benefits of early intervention has become...
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Review of comorbidities and risk factors for the development of migraine complications (infarct and chronic migraine): Dodick DW. Review of comorbidities and risk factors for the development of migraine complications (infarct and chronic migraine). Cephalalgia 2009; 29 (Suppl. 3):7–14. London. ISSN 0333‐1024A number of comorbid disorders, behavioural traits and associated risk factors in patients with migraine are known to increase the risk of complications such as ischaemic vascular events and chronic...
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Modulation of trigeminovascular processing: novel insights into primary headache disorders: Holland PR. Modulation of trigeminovascular processing: novel insights into primary headache disorders. Cephalalgia 2009; 29 (Suppl. 3):1–6. London. ISSN 0333‐1024Dysfunction of the descending circuitry that modulates nociceptive processing is thought to facilitate primary headache disorders such as migraine and cluster headache, either by reducing inhibition or increasing facilitation of neural signals. The...
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Hearing Aid Treatment for Patients with Mixed Hearing Loss. Part II: Speech Recognition in Comparison to Direct Acoustic Cochlear Stimulation: Background: The conventional therapy for severe mixed hearing loss is middle ear surgery combined with a power hearing aid. However, a substantial group of patients with severe mixed hearing loss cannot be treated adequately with today's state-of-the-art (SOTA) power hearing aids, as predicted by the accompanying part I of this publication, where we compared...
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Effectiveness of Bone Conduction Stimulation Applied Directly to the Otic Capsule Measured at Promontory: Assessment in Cadavers: Introduction: The aims of this study included: (a) to develop a method of direct acoustic bone conduction (BC) stimulation applied directly to the otic capsule, (b) to investigate the effect of different stimulation sites on the promontory displacement amplitude, and (c) to find the best stimulation site (among 2 located directly on the otic capsule and 1 standard site...
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Cochlear Implantation in Patients with Chronic Suppurative Otitis Media: Surgical Outcomes and a Management Algorithm: Background: Chronic suppurative otitis media (CSOM) was considered as a contraindication of cochlear implantation (CI) in the past. Recently, various surgical options have been adopted for CI in CSOM patients with showing a low complication rate. Objectives: To evaluate surgical outcomes of CI in patients with CSOM and to propose a management algorithm for those patients. Methods:...
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Hearing Aid Treatment in Patients with Mixed Hearing Loss. Part I: Expected Benefit and Limitations after Stapes Surgery: Objective: The purpose of the present study was to determine the fraction of patients with mixed hearing loss who can or cannot expect benefit from power hearing aids (HAs) after stapes surgery. Design: The audiological outcome of 374 stapes surgeries was used to calculate the patients' individual postoperative requirements in terms of gain and output of HAs. These requirements...
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Ethics in Audiology Today: This presentation provides audiologists with practical information on ethical conduct and decision making in clinical and educational settings. Specific topics include ethical concerns and considerations important in the interaction of audiologists with clinical and academic professionals, students, industry representatives, and patients and their families.
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20Q: Utilization of the ICS Impulse vs ICS ChartR VNG for Oculomotor Assessment: This 20Q discussion describes the use of the ICS Impulse for the assessment of the oculomotor pathway in patients with vestibular pathology. Specific attention will be given regarding which tests analyze similar neurological pathways. The use of a different protocol using the ICS goggles compared to using the traditional VNG protocol will be explored.
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New App Could Improve Listening Abilities of Children with Communication Disorders: Smarty Ears has received a grant from the National Institute of Health (NIH) to develop a technology that will help children who have difficulty understanding speech in noisy conditions. With this Small Business Innovation Research (SBIR) grant, the group aims to develop an innovative adaptive listening training system in the form of an iPad application (app) and to gather preliminary data to validate the usability...
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Influence of maternal diet on flavor transfer to amniotic fluid and breast milk and children's responses: a systematic review.: Related ArticlesInfluence of maternal diet on flavor transfer to amniotic fluid and breast milk and children's responses: a systematic review.Am J Clin Nutr. 2019 03 01;109(Suppl_7):1003S-1026SAuthors: Spahn JM, Callahan EH, Spill MK, Wong YP, Benjamin-Neelon SE, Birch L, Black MM, Cook JT, Faith MS, Mennella JA, Casavale KOAbstract BACKGROUND: Maternal diet during...
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Repeated exposure to food and food acceptability in infants and toddlers: a systematic review.: Related ArticlesRepeated exposure to food and food acceptability in infants and toddlers: a systematic review.Am J Clin Nutr. 2019 03 01;109(Suppl_7):978S-989SAuthors: Spill MK, Johns K, Callahan EH, Shapiro MJ, Wong YP, Benjamin-Neelon SE, Birch L, Black MM, Cook JT, Faith MS, Mennella JA, Casavale KOAbstract BACKGROUND: Repeated exposure has been found to be an effective strategy to increase...
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Lipopolysaccharide-Induced Inflammatory Cytokine Expression in Taste Organoids.: Related ArticlesLipopolysaccharide-Induced Inflammatory Cytokine Expression in Taste Organoids.Chem Senses. 2020 Jan 29;:Authors: Feng S, Achoute L, Margolskee RF, Jiang P, Wang HAbstract Inflammatory cytokines are signaling molecules that regulate numerous physiological processes, from tissue homeostasis to metabolism and food intake. Expression of certain cytokines can be markedly induced in subsets of taste...
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Exposure to a slightly sweet lipid-based nutrient supplement during early life does not increase the level of sweet taste most preferred among 4- to 6-year-old Ghanaian children: follow-up of a randomized controlled trial.: Related ArticlesExposure to a slightly sweet lipid-based nutrient supplement during early life does not increase the level of sweet taste most preferred among 4- to 6-year-old Ghanaian children: follow-up of a randomized controlled trial.Am J Clin Nutr. 2019 04 01;109(4):1224-1232Authors:...
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Broncho-Vaxom® (OM-85 BV) soluble components stimulate sinonasal innate immunity.: Related ArticlesBroncho-Vaxom® (OM-85 BV) soluble components stimulate sinonasal innate immunity.Int Forum Allergy Rhinol. 2019 04;9(4):370-377Authors: Triantafillou V, Workman AD, Patel NN, Maina IW, Tong CCL, Kuan EC, Kennedy DW, Palmer JN, Adappa ND, Waizel-Haiat S, Cohen NAAbstract BACKGROUND: Broncho-Vaxom® (OM-85 BV) is an extract of infectious respiratory bacteria that is used as an immunostimulant...
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Non-invasive recording from the human olfactory bulb.: Related ArticlesNon-invasive recording from the human olfactory bulb.Nat Commun. 2020 Jan 31;11(1):648Authors: Iravani B, Arshamian A, Ohla K, Wilson DA, Lundström JNAbstract Current non-invasive neuroimaging methods can assess neural activity in all areas of the human brain but the olfactory bulb (OB). The OB has been suggested to fulfill a role comparable to that of V1 and the thalamus in the visual system and have been closely linked...
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Segregated expression of ENaC subunits in taste cells.: Related ArticlesSegregated expression of ENaC subunits in taste cells.Chem Senses. 2020 Feb 01;:Authors: Lossow K, Hermans-Borgmeyer I, Meyerhof W, Behrens MAbstract Salt taste is one of the 5 basic taste qualities. Depending on the concentration, table salt is perceived either as appetitive or aversive, suggesting the contribution of several mechanisms to salt taste, distinguishable by their sensitivity to the epithelial sodium channel...
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Neuropeptide S displays as a key neuromodulator in olfactory spatial memory.: Related ArticlesNeuropeptide S displays as a key neuromodulator in olfactory spatial memory.Chem Senses. 2020 Feb 03;:Authors: Wang C, Xin L, Cai CC, Cong CY, Xie JF, Kong XP, Dong CY, Li J, Cui GF, Chen HL, Ren YL, Shao YF, Hou YPAbstract Neuropeptide S (NPS) is an endogenous peptide recently recognized to be presented in the brainstem, and believed to play an important role in maintaining memory. The deletion...
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The impact of ovariectomy on olfactory neuron regeneration in mice.: Related ArticlesThe impact of ovariectomy on olfactory neuron regeneration in mice.Chem Senses. 2020 Feb 03;:Authors: Yamada K, Shiga H, Noda T, Harita M, Ishikura T, Nakamura Y, Hatta T, Sakata-Haga H, Shimada H, Miwa TAbstract Estrogen has been shown to affect differentiation and proliferation as a mitogen in various neural systems. Olfactory receptor cells are unique within the nervous system, and have the ability to...
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Exploring Beneficial/Virulence Properties of Two Dairy-Related Strains of Streptococcus infantarius subsp. infantarius.: Related ArticlesExploring Beneficial/Virulence Properties of Two Dairy-Related Strains of Streptococcus infantarius subsp. infantarius.Probiotics Antimicrob Proteins. 2020 Jan 24;:Authors: Dos Santos KMO, de Matos CR, Salles HO, de Melo Franco BDG, Arellano K, Holzapfel WH, Todorov SDAbstract The genus Streptococcus includes various species, remarkably different in their...
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Abundance of Lactobacillus plantarum Strains with Beneficial Attributes in Blackberries (Rubus sp.), Fresh Figs (Ficus carica), and Prickly Pears (Opuntia ficus-indica) Grown and Harvested in Algeria.: Related ArticlesAbundance of Lactobacillus plantarum Strains with Beneficial Attributes in Blackberries (Rubus sp.), Fresh Figs (Ficus carica), and Prickly Pears (Opuntia ficus-indica) Grown and Harvested in Algeria.Probiotics Antimicrob Proteins. 2020 Jan 24;:Authors: Barache N, Ladjouzi R, Belguesmia...
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Potential Probiotics Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895 Co-Aggregate with Clinical Isolates of Proteus mirabilis and Prevent Biofilm Formation.: Related ArticlesPotential Probiotics Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895 Co-Aggregate with Clinical Isolates of Proteus mirabilis and Prevent Biofilm Formation.Probiotics Antimicrob Proteins. 2020 Jan 27;:Authors: Algburi A, Alazzawi SA, Al-Ezzy AIA, Weeks R, Chistyakov V, Chikindas MLAbstract...
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Treatment of chronic subdural hematoma with atorvastatin combined with low-dose dexamethasone: phase II randomized proof-of-concept clinical trial.: Related ArticlesTreatment of chronic subdural hematoma with atorvastatin combined with low-dose dexamethasone: phase II randomized proof-of-concept clinical trial.J Neurosurg. 2020 Jan 31;:1-9Authors: Wang D, Gao C, Xu X, Chen T, Tian Y, Wei H, Zhang S, Quan W, Wang Y, Yue S, Wang Z, Lei P, Anderson C, Dong J, Zhang J, Jiang RAbstract OBJECTIVE:...
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Long-term outcomes after endoscopic endonasal surgery for nonfunctioning pituitary macroadenomas.: Related ArticlesLong-term outcomes after endoscopic endonasal surgery for nonfunctioning pituitary macroadenomas.J Neurosurg. 2020 Jan 31;:1-12Authors: Gerges MM, Rumalla K, Godil SS, Younus I, Elshamy W, Dobri GA, Kacker A, Tabaee A, Anand VK, Schwartz THAbstract OBJECTIVE: Nonfunctioning pituitary adenomas are benign, slow-growing tumors. After gross-total resection (GTR) or subtotal resection...
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Outcomes of Cushing's disease following Gamma Knife radiosurgery: effect of a center's growing experience and era of treatment.: Related ArticlesOutcomes of Cushing's disease following Gamma Knife radiosurgery: effect of a center's growing experience and era of treatment.J Neurosurg. 2020 Jan 31;:1-8Authors: Bunevicius A, Sheehan D, Lee Vance M, Schlesinger D, Sheehan JPAbstract OBJECTIVE: Stereotactic radiosurgery (SRS) is used for the management of residual or recurrent Cushing's disease...
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Deep brain stimulation for aggressiveness: long-term follow-up and tractography study of the stimulated brain areas.: Related ArticlesDeep brain stimulation for aggressiveness: long-term follow-up and tractography study of the stimulated brain areas.J Neurosurg. 2020 Feb 07;:1-10Authors: Torres CV, Blasco G, Navas García M, Ezquiaga E, Pastor J, Vega-Zelaya L, Pulido Rivas P, Pérez Rodrigo S, Manzanares RAbstract OBJECTIVE: Initial studies applying deep brain stimulation (DBS) of the posteromedial...
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MR-guided focused ultrasound cerebellothalamic tractotomy for chronic therapy-resistant essential tremor: anatomical target reappraisal and clinical results.: Related ArticlesMR-guided focused ultrasound cerebellothalamic tractotomy for chronic therapy-resistant essential tremor: anatomical target reappraisal and clinical results.J Neurosurg. 2020 Feb 07;:1-10Authors: Gallay MN, Moser D, Jeanmonod DAbstract OBJECTIVE: In addition to the well-recognized ventral intermediate nucleus (Vim) thalamotomy...
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Epidemiology, natural history, and optimal management of neurohypophyseal germ cell tumors.: Related ArticlesEpidemiology, natural history, and optimal management of neurohypophyseal germ cell tumors.J Neurosurg. 2020 Feb 07;:1-9Authors: Takami H, Graffeo CS, Perry A, Giannini C, Daniels DJAbstract OBJECTIVE: Intracranial germ cell tumors (iGCTs) often arise at the neurohypophysis, their second most common origination, following the pineal region. Neurohypophyseal iGCTs present with stereotypical...
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Objective quantification of contrast enhancement of unruptured intracranial aneurysms: a high-resolution vessel wall imaging validation study.: Related ArticlesObjective quantification of contrast enhancement of unruptured intracranial aneurysms: a high-resolution vessel wall imaging validation study.J Neurosurg. 2020 Feb 07;:1-8Authors: Roa JA, Zanaty M, Osorno-Cruz C, Ishii D, Bathla G, Ortega-Gutierrez S, Hasan DM, Samaniego EAAbstract OBJECTIVE: High-resolution vessel wall imaging (HR-VWI)...
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Early postoperative MRI and detection of residual adenoma after transsphenoidal pituitary surgery.: Related ArticlesEarly postoperative MRI and detection of residual adenoma after transsphenoidal pituitary surgery.J Neurosurg. 2020 Feb 07;:1-10Authors: Alhilali LM, Little AS, Yuen KCJ, Lee J, Ho TK, Fakhran S, White WLAbstract OBJECTIVE: Current practice guidelines recommend delayed (≥ 3 months after operation) postoperative MRI after transsphenoidal surgery for pituitary adenomas, although...
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Short- and long-term cognitive effects of deep brain stimulation in the caudal zona incerta versus best medical treatment in patients with Parkinson's disease.: Related ArticlesShort- and long-term cognitive effects of deep brain stimulation in the caudal zona incerta versus best medical treatment in patients with Parkinson's disease.J Neurosurg. 2020 Feb 07;:1-9Authors: Philipson J, Blomstedt P, Fredricks A, Hariz M, Stenmark Persson R, Jahanshahi MAbstract OBJECTIVE: A growing number of...
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Cranial flap fixation in sheep using a resorbable bone adhesive.: Related ArticlesCranial flap fixation in sheep using a resorbable bone adhesive.J Neurosurg. 2020 Feb 07;:1-9Authors: Foley KT, Woodard EJ, Slotkin JR, Mayotte CK, Baldwin AC, Brown MC, Hess BJAbstract OBJECTIVE: The authors' goal in this study was to investigate the use of a novel, bioresorbable, osteoconductive, wet-field mineral-organic bone adhesive composed of tetracalcium phosphate and phosphoserine (TTCP-PS) for cranial...
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Histone deacetylase (HDAC) inhibitors in cancer: a patent review (2017-present).: Related ArticlesHistone deacetylase (HDAC) inhibitors in cancer: a patent review (2017-present).Expert Opin Ther Pat. 2020 Feb 01;:Authors: Zhao C, Dong H, Xu Q, Zhang YAbstract Introduction: Histone deacetylase (HDAC) inhibitors play a crucial role in restoring the balance of acetylation and deacetylation of lysine residues of histones and non-histone proteins, which are applied to treat several diseases including...
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Advances in patent applications related to cancer vaccine using CpG-ODN and OX40 association.: Related ArticlesAdvances in patent applications related to cancer vaccine using CpG-ODN and OX40 association.Expert Opin Ther Pat. 2020 Feb 01;:Authors: Quintella CM, Quintella HM, Rohweder M, Quintella GMAbstract Introduction: This review aims to assess the available technologies, advances and trends from technological readiness level 4 to level 8 for cancer immunologic therapeutics using the association...
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Antibiotics in wastewater from multiple sources and surface water of the Yangtze River in Chongqing in China.: Related ArticlesAntibiotics in wastewater from multiple sources and surface water of the Yangtze River in Chongqing in China.Environ Monit Assess. 2020 Feb 03;192(3):159Authors: Shi Y, Liu J, Zhuo L, Yan X, Cai F, Luo W, Ren M, Liu Q, Yu YAbstract Antibiotic contamination attracts growing concerns because of their deleterious effects on the ecosystem and human health. In this study,...
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Quantification of heavy metal pollution for environmental assessment of soil condition.: Related ArticlesQuantification of heavy metal pollution for environmental assessment of soil condition.Environ Monit Assess. 2020 Feb 04;192(3):162Authors: Askari MS, Alamdari P, Chahardoli S, Afshari AAbstract The aim of this study was to quantify heavy metal pollution for environmental assessment of soil quality using a flexible approach based on multivariate analysis. The study was conducted using...
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Quantitative assessment of background pollutants using a modified method in data-poor regions.: Related ArticlesQuantitative assessment of background pollutants using a modified method in data-poor regions.Environ Monit Assess. 2020 Feb 04;192(3):160Authors: Duan M, Du X, Peng W, Jiang C, Zhang S, Ding YAbstract Heavy background pollutant loads pose a difficult problem for the assessment and management of regional water quality, especially in areas where surface water quality is less affected...
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Estimation of arsenic background concentration in stream sediments in Zia-Abad area (NW Iran).: Related ArticlesEstimation of arsenic background concentration in stream sediments in Zia-Abad area (NW Iran).Environ Monit Assess. 2020 Feb 06;192(3):165Authors: Maanijou M, Poursheikhi E, Ramezani TAbstract Zia-Abad is in Qazvin Province (NW Iran), with many farmlands that cover all parts of the area. The purpose of this research is to determine the background concentration of arsenic in stream...
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Geoassessment of heavy metals in rural and urban floodplain soils: health implications for consumers of Celosia argentea and Corchorus olitorius vegetables in Sagamu, Nigeria.: Related ArticlesGeoassessment of heavy metals in rural and urban floodplain soils: health implications for consumers of Celosia argentea and Corchorus olitorius vegetables in Sagamu, Nigeria.Environ Monit Assess. 2020 Feb 05;192(3):164Authors: Oguntade OA, Adegbuyi AA, Nassir AL, Olagunju SO, Salami WA, Adewale ROAbstract...
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Nutritional status and follicular-derived thyroid cancer: An update.: Related ArticlesNutritional status and follicular-derived thyroid cancer: An update.Crit Rev Food Sci Nutr. 2020 Jan 30;:1-35Authors: Barrea L, Gallo M, Ruggeri RM, Giacinto PD, Sesti F, Prinzi N, Adinolfi V, Barucca V, Renzelli V, Muscogiuri G, Colao A, Baldelli R, E.O.L.O. GroupAbstract The incidence of differentiated thyroid cancer has been increasing in the last decades all over the world. Such a steady growth cannot...
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Outbreaks, occurrence, and control of norovirus and hepatitis a virus contamination in berries: A review.: Related ArticlesOutbreaks, occurrence, and control of norovirus and hepatitis a virus contamination in berries: A review.Crit Rev Food Sci Nutr. 2020 Feb 03;:1-23Authors: Bozkurt H, Phan-Thien KY, van Ogtrop F, Bell T, McConchie RAbstract Foodborne enteric viruses, in particular HuNoV and HAV, are the most common cause of the berry-linked viral diseases, and outbreaks around the world,...
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Nutritive vitamins as epidrugs.: Related ArticlesNutritive vitamins as epidrugs.Crit Rev Food Sci Nutr. 2020 Feb 05;:1-13Authors: Nur SM, Rath S, Ahmad V, Ahmad A, Ateeq B, Khan MIAbstract Epigenetic modifications play an important role in disease pathogenesis and therefore are a focus of intense investigation. Epigenetic changes include DNA, RNA, and histone modifications along with expression of non-coding RNAs. Various factors such as environment, diet, and lifestyle can influence the...
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Identification of human papillomavirus in oral rinse specimens from women with and without cervical intraepithelial lesions.: Related ArticlesIdentification of human papillomavirus in oral rinse specimens from women with and without cervical intraepithelial lesions.Sex Transm Infect. 2020 Feb 11;:Authors: Nemesio I, Cury F, Longatto-Filho A, Fregnani JH, Musselwhite L, Vazquez F, Peters AC, Oliveira CAbstract OBJECTIVES: The objective of this study was to evaluate the frequency of human papillomavirus...
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Treatment of conjunctival papilloma with topical interferon alpha-2b - case report.: Related ArticlesTreatment of conjunctival papilloma with topical interferon alpha-2b - case report.Medicine (Baltimore). 2020 Feb;99(7):e19181Authors: Bolek B, Wylęgała A, Teper S, Kokot J, Wylęgała EAbstract RATIONALE: Conjunctival papilloma is a benign neoplastic lesion of epithelial origin, with a minimal tendency toward malignancy and an exophytic growth type. Etiological factors that contribute to the...
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Effect of the sense of coherence and associated factors in the quality of life of head and neck cancer patients: Abstract The sense of coherence (SOC) is a measure of global orientation regarding the ability of individuals to cope with stressful situations. The aim of the present study was to evaluate the association between SOC and quality of life (QoL) and clinical and sociodemographic characteristics among survivors of oral, oropharynx, hypopharynx, or larynx cancer. A cross-sectional study was...
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Cyclosporine A impairs bone repair in critical defects filled with different osteoconductive bone substitutes: Abstract The aim of this study was to assess the influence of cyclosporine administration on the repair of critical-sized calvaria defects (CSDs) in rat calvaria filled with diverse biomaterials. Sixty animals were divided into two groups: the control (CTR) group (saline solution) and the cyclosporine (CCP) group (cyclosporine, 10 mg/kg/day). These medications were administered daily by...
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Pam2CSK4 (TLR2 agonist) induces periodontal destruction in mice: Abstract Lipoproteins are important bacterial immunostimulating molecules capable of inducing receptor activator of nuclear factor-κB (RANKL) and osteoclast formation in vitro and in vivo . Although these molecules are present in periodontopathogenic bacteria, their role in periodontitis is not known. In this study, we used Pam2CSK4 (PAM2), a synthetic molecule that mimics bacterial lipoprotein, to investigate the effects of lipoproteins...
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Expression profile of salivary micro RNA-21 and 31 in oral potentially malignant disorders: Abstract Oral potentially malignant disorders (OPMD) possess significant chances of malignancy conversion. In order to develop an early diagnostic tool, the present study evaluated the expression of miRNA-21 and 31 as salivary markers. The case-control study was carried out in 36 healthy participants as controls and in 36 patients who were newly diagnosed as OPMD having four different lesions including leucoplakia,...
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Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA: AbstractNon-coding RNAs do not encode proteins and regulate various oncological processes. They are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics and translation omics have begun to elucidate the roles and modes of action of the functional peptides encoded by ncRNA. Here, recent advances in long non-coding RNA (lncRNA) and circular RNA (circRNA)-encoded small peptides are compiled...
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Immune‐related adverse events correlate with improved survival in patients with advanced mucosal melanoma treated with nivolumab: A single‐center retrospective study in Japan: AbstractImmune‐related adverse events (irAE) were reported to be associated with better outcomes in various cancers treated with the immune checkpoint inhibitor nivolumab. Considering that their development depends on host immune activation, irAE may reflect antitumor response in mucosal melanoma (MM). This single‐center retrospective...
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Immune‐related adverse events correlate with improved survival in patients with advanced mucosal melanoma treated with nivolumab: A single‐center retrospective study in Japan: AbstractImmune‐related adverse events (irAE) were reported to be associated with better outcomes in various cancers treated with the immune checkpoint inhibitor nivolumab. Considering that their development depends on host immune activation, irAE may reflect antitumor response in mucosal melanoma (MM). This single‐center retrospective...
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Retrospective study of photodynamic therapy for pulsed dye laser‐resistant port‐wine stains: AbstractPulsed dye laser‐resistant port‐wine stains present a therapeutic challenge. The aim of this study was to evaluate the efficacy and safety of photodynamic therapy for treating these lesions. A total of 67 patients with pulsed dye laser‐resistant cervicofacial port‐wine stains were retrospectively assessed after undergoing photodynamic therapy mediated with a combination of hemoporfin and 532‐nm light....
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Local and disease control for nasal melanoma treated with radiation and concomitant anti‐programmed death 1 antibody: AbstractMucosal melanoma of the nasal cavity is a rare disease that has been consistently associated with poor outcome. While complete surgical excision offers the only prospect of a cure, it is associated with a high risk of surgical morbidity due to the challenging anatomical location, and most patients still develop incurable metastatic disease. The efficacy of immunotherapy on...
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Prospective trial for the clinical efficacy of anogenital skin care with miconazole nitrate‐containing soap for diaper candidiasis: AbstractAnogenital skin care for the elderly remains an umbrella term concerning protective and non‐interventional regimens, particularly for ordinary diaper users. Our recent investigation has demonstrated the preventive effect of daily anogenital washing with miconazole nitrate‐containing soap to the development of diaper candidiasis. We extended this work to cover...
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Prevalence of infectious diseases in patients with autoimmune blistering diseases: AbstractA long‐term immunosuppressive treatment can provoke latent infections. Autoimmune blistering diseases (AIBD) are mostly treated with systemic immunosuppressive agents. To prevent the reactivation or exacerbation of existing latent infections, patients must be screened for infectious diseases before immunosuppressive treatments are initiated. However, the prevalence of infectious diseases in AIBD remains to...
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Role of BP230 autoantibodies in bullous pemphigoid: AbstractBullous pemphigoid (BP) is an autoimmune disease associated with subepidermal blistering due to autoantibodies directed against BP180 and BP230. BP180 is currently considered as the major pathogenic autoantigen. However, previous clinical findings suggested that anti‐BP230 autoantibodies alone can cause skin lesions in animal models and many BP patients. The characteristics of BP230 and the pathogenic roles of anti‐BP230 antibodies have...
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Iatrogenic Kaposi's sarcoma in a myelofibrosis patient treated with ruxolitinib:
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Prognostication of oral squamous cell carcinoma patients based on tumor‐stroma ratio and tumor budding: AbstractAimsPrevious studies have demonstrated that tumor‐stroma ratio (TSR) and tumor budding are of prognostic value for oral squamous cell carcinomas (OSCC). Herein we evaluated the prognostic significance of those histological parameters, individually and in combination, for OSCC.MethodsTSR and tumor budding (the presence of ≥ 5 buds at the invasive front) were estimated in 254 patients with...
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Lymphovascular Invasion in Early Gastric Cancer: Impact of Ancillary D2‐40 and Elastin Staining on Interobserver Agreement: AbstractBackground and AimLymphatic invasion (LI) and venous invasion (VI) are the strongest risk factors for lymph node metastasis in patients with early gastric cancer, and may predict their prognosis. We aimed to investigate interobserver agreement among pathologists before and after adding ancillary staining for diagnosing LI and VI in this setting.MethodsThis retrospective...
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A novel risk score to predict early and late recurrence in solitary fibrous tumour: AbstractAimsSolitary fibrous tumours (SFTs) are rare mesenchymal neoplasms with recurrence rates of 10‐30%. Current risk stratification systems for extrameningeal SFTs are based on cohorts with limited follow‐up and are not suitable for prediction of late recurrences. In this study we aimed to develop a prognostic model accounting for both early and late recurrences using a relatively large patient cohort with long‐term...
08:26
Recurrent RET Gene Fusions in Pediatric Spindle Mesenchymal Neoplasms: AbstractAimsThe classification of pediatric spindle mesenchymal tumors is evolving, and the spectrum of so‐called "infantile fibrosarcoma" has expanded to include tumors with NTRK, BRAF, and MET gene fusions. RET‐rearranged pediatric spindle cell neoplasms are an emerging group; there is sparse literature on their clinical, pathologic and genetic features, and their nosologic place in the canon of soft tissue tumors is uncertain....
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Digital pathology for primary diagnosis of screen‐detected breast lesions – experimental data, validation and experience from 4 centres: AbstractAimThe rate of deployment of digital pathology (DP) systems for primary diagnosis in the UK is accelerating. The flexibility and resilience of digital slides versus standard glass slides could be of great benefit in the NHS breast screening programme (NHSBSP). This study aims to document the safety and benefits of DP for preoperative tissue diagnosis of...
08:26
Gastric and duodenal ulcers, periodontal disease, and risk of bladder cancer in the Health Professionals Follow-up Study: AbstractPurposeStudies suggest that peptic ulcer and periodontal disease are positively associated with bladder cancer risk. These two factors are likely to share common biologic mechanisms such as inflammation and dysbiosis. We examined the joint association of peptic ulcer (gastric/duodenal) and periodontal disease on bladder cancer risk.MethodsWe conducted a prospective analysis...
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The Climate Crisis and Clinical Practice: "A wave of heat hit us as we opened the door, like we were in the Sahara Desert!" Sweat was beading on the forehead of the emergency medical technician as he wheeled in an elderly man with a reported fever, whose apparent confusion had led his wife to call 911. In the midst of a record-breaking…
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Mesenchymal Tumors with RREB1‐MRTFB Fusion Involving the Mediastinum: Extra‐Glossal Ectomesenchymal Chondromyxoid Tumors?: AbstractAimsEctomesenchymal chondromyxoid tumor (ECT) is a rare benign intraoral tumor, which almost exclusively presents as a small mass of the anterior dorsal tongue. Recently, the RREB1‐MRTFB (previously known as MKL2) fusion gene has been identified in 90% of ECTs, all located in the tongue, emphasizing its genetic distinctiveness. Here, we report two mesenchymal tumors involving...
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Frequent KRAS Mutations in Oncocytic Papillary Renal Neoplasm with Inverted Nuclei: AbstractAimsPapillary renal neoplasm with reverse polarity (PRNRP) is a newly documented rare tumour type. Its molecular pathological features have thus far been studied very little.Methods and resultsThree PRNRPs were found in The Cancer Genome Atlas (TCGA) database using a combination of GATA3 mRNA expression levels and digital slides from the TCGA papillary renal cell carcinoma project. KRAS codon 12 mutations...
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A Novel Coronavirus Emerging in China — Key Questions for Impact Assessment: A novel coronavirus, designated as 2019-nCoV, emerged in Wuhan, China, at the end of 2019. As of January 24, 2020, at least 830 cases had been diagnosed in nine countries: China, Thailand, Japan, South Korea, Singapore, Vietnam, Taiwan, Nepal, and the United States. Twenty-six fatalities occurred,…
08:23
Allergy, asthma, and the risk of breast and prostate cancer: a Mendelian randomization study: AbstractPurposeThe relationship of allergic diseases, such as asthma, hay fever, and eczema, with cancer is under debate. Observational studies have reported conflicting findings, but such studies are susceptible to confounding and reverse causation. Understanding the potential role of allergy in carcinogenesis may shed new light on the biological mechanisms underpinning intrinsic immunity and cancer.MethodsWe...
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Obesity and efficacy of vitamin D 3 supplementation in healthy black adults: AbstractPurposeResults from recent clinical trials suggest that vitamin D efficacy against cancer may be influenced by body mass index. As suppression of parathyroid hormone (PTH) is one indicator of vitamin D efficacy, we examined to what extent doses of vitamin D3 supplementation suppress PTH levels in individuals with and without obesity.MethodsA total of 328 healthy African Americans were randomized into the following...
08:21
The Rate of Incidental Atypical and Malignant Breast Lesions in Reduction Mammoplasty Specimens: AbstractAimsReduction mammoplasty (RM) is one of the most common plastic surgeries in the US. We aimed to demonstrate the rate of incidental atypical and malignant breast lesions (AMBL) found in RM specimens and the impact of the number of submitted tissue sections on the rate of ABL.Methods and ResultsWe analyzed our database for patients who underwent reduction mammoplasty between 2000 and 2018. Patients...
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Post‐radiotherapy vascular lesions of the breast: immunohistochemical and molecular features of 74 cases with long term follow up and literature review: AbstractIntroductionA wide range of post‐radiotherapy vascular lesions can occur, ranging from Benign lymph‐angiomatous papule of the skin (BLAP), to Atypical vascular Lesions (AVL) and post‐RT angiosarcomas (Post‐RT AS). The relationship between benign and malignant post‐RT breast lesions and their prognostic features is still controversial.Aim...
08:20
Whole‐Exome Analysis of Metaplastic Breast Carcinomas with Extensive Osseous Differentiation: AbstractAimsMetaplastic breast carcinoma (MBC) is a rare type of triple‐negative breast cancer that displays vast histologic and genetic heterogeneity. Osseous differentiation can be found in different subtypes of MBC. Whether MBCs with osseous differentiation are underpinned by specific genetic alterations has yet to be defined. Here we investigate the repertoire of somatic mutations and copy number alterations...
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The 2019 WHO classification of tumours of the breast: AbstractThe newly published World Health Organization (WHO) Classification of Tumours of the breast features significant changes compared to earlier editions. In this review, we outline the major changes in this important reference source for those diagnosing tumours, or engaged in cancer research, and describe the significant changes. For breast cancer, the overview acknowledges the treatment‐relevant subtypes of invasive carcinoma (based on...
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Group and Individual fMRI Analysis of the Main Resting State Networks in Healthy Subjects: Analysis of fMRI in the resting state (RS) is a suitable methodological approach to studying basal levels of functional brain activity in humans in health and disease. The inadequate development of this direction in Russia is partly due to the small number of Russian publications describing approaches to data processing. This study uses an algorithm for analysis of fMRI signals in the RS based on independent...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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