Selenium in cisplatin-induced testicular damage
Ameliorative effect of selenium in cisplatin-induced testicular damage in rats via Acta Histochemica Publication date: Available online 23 February 2016 *Source:*Acta Histochemica Author(s): Nejdet Simsek, Akif Koc, Ali Karadeniz, Mehmet Erol Yildirim, Hüseyin Tuğrul Celik, Erhan Sari, Adem Kara In this study, we investigated the protective effect of selenium (Se) on cisplatin (Cis) induced testicular damage using histopathological, immunohistochemical and biochemical approaches. Twenty-one male Wistar rats were equally divided into three groups of seven rats each: control (C), Cis, a...περισσότερα »
Malignancy rate associated with Bethesda category III (AUS/FLUS) with and without repeat fine needle aspiration biopsy
Malignancy rate associated with Bethesda category III (AUS/FLUS) with and without repeat fine needle aspiration biopsy: Background Selection of nodules for surgery diagnosed as Bethesda category III [atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) category] is important. It was aimed to define the malignancy rates associated with and without repeat fine needle aspiration biopsy (FNAB) and to define the contribution of repeat FNAB to triage to surgery or observation in nodules with AUS/FLUS FNAB. Methods The records of all patients with n... περισσότερα »
The Possible Role of Mast Cells in the Odontogenic Cyst’s Pathogenesis: A Comparative Study between Dentigerous Cyst and Keratocystic Odontogenic Tumor
The Possible Role of Mast Cells in the Odontogenic Cyst’s Pathogenesis: A Comparative Study between Dentigerous Cyst and Keratocystic Odontogenic Tumor: Background. Recently, mast cells were recognized in the pathogenesis of more aggressive pathologic lesions. This study was aimed to evaluate and compare the density of mast cells in Dentigerous cyst (DC) and Keratocystic odontogenic tumor (KCOT) regarding their different clinical behavior. Method. This study was conducted on 23 and 26 cases of DC and KCOT, respectively. Four-micron sections were prepared for Toluidine blue staining ... περισσότερα »
Multifocal Pulmonary Langerhans Cell Histiocytosis
Mutually exclusive ERK Pathway Mutations are present in different stages of multifocal Pulmonary Langerhans Cell Histiocytosis supporting clonal nature of the disease: [image: cover.gif?v=1&s=8f136cff64026803a483ac56] Abstract Aims Pulmonary Langerhans Cell Histiocytosis (PLCH) is an idiopathic cigarette smoking related disorder of the lung. Molecular changes in cellular or fibrotic stages of PLCH have not been investigated. We studied the prevalence of ERK pathway mutations in different PLCH stages and other non-PLCH smoking related lung diseases. Methods and results The cohort... περισσότερα »
Plasmacytoid-Type Cellular Differentiation in Polymorphous Low-Grade Adenocarcinoma
Plasmacytoid-Type Cellular Differentiation in Polymorphous Low-Grade Adenocarcinoma: *Introduction.* *Polymorphous low-grade adenocarcinoma (PLGA) occurs more frequently in minor salivary glands. *The diagnosis of PLGA, in general, is not difficult but in occasional tumors showing limited invasion or in small biopsy specimens, PLGA may be confused with cellular pleomorphic adenoma (PA). Plasmacytoid cells, a usual component of PAs, have been considered helpful for correct tumor identification. *Objective.* The aim of this study was to verify the frequency (if any) of plasmacytoid-t...περισσότερα »
Aldosterone mediates metastatic spread of renal cancer via the G protein-coupled estrogen receptor (GPER) Research
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
Although aldosterone is a known regulator of renal and cardiovascular function, its role as a regulator of cancer growth and spread has not been widely considered. This study tested the hypothesis that aldosterone regulates cancer cell growth/spread via G protein–coupled estrogen receptor (GPER) activation. In vitro in murine renal cortical adenocarcinoma (RENCA) cells, a widely […]
Giving back: Harvard Lions Club shows love of community by more than fundraising – Harvard Press
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
Giving back: Harvard Lions Club shows love of community by more than fundraising Harvard Press The Harvard Lions Club offers similar kinds of programs and support, from hosting the Bare Hill Triathlon each year, to supporting cancer organizations in town, such as the Virginia Thurston Healing Garden, and providing assistance for families in need … […]
A writer is put to the test by the Mariners’ medical staff – The Seattle Times
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
The Seattle Times A writer is put to the test by the Mariners’ medical staff The Seattle Times So if he sees something, we fix it in the spring. He also does a pre-cancer screening. They check their tongue, their glands, they check the inside of the mouth for any cancerous lesions. We’ve been doing […]
Liposomal nanocarriers for plasminogen activators
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
Publication date: 10 April 2016 Source:Journal of Controlled Release, Volume 227 Author(s): Stepan Koudelka, Robert Mikulik, Josef Mašek, Milan Raška, Pavlína Turánek Knotigová, Andrew D. Miller, Jaroslav Turánek Several plasminogen activators (PAs) have been found effective in treating different thromboembolic diseases. However, administration of conventional thrombolytic therapy is limited by a low efficacy of present […]
Analyzing spatiotemporal distribution of uniquely fluorescent nanoparticles in xenograft tumors
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
Publication date: 10 April 2016 Source:Journal of Controlled Release, Volume 227 Author(s): Darren L. Stirland, Yu Matsumoto, Kazuko Toh, Kazunori Kataoka, You Han Bae A dose circulating through the blood at one time will have different opportunities to access the tumor compared to a dose circulating hours later. Methods to test this hypothesis allowed us […]
Nanocarriers for the treatment of glioblastoma multiforme: Current state-of-the-art
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
Publication date: 10 April 2016 Source:Journal of Controlled Release, Volume 227 Author(s): Reatul Karim, Claudio Palazzo, Brigitte Evrard, Geraldine Piel Glioblastoma multiforme, a grade IV glioma, is the most frequently occurring and invasive primary tumor of the central nervous system, which causes about 4% of cancer-associated-deaths, making it one of the most fatal cancers. With […]
Improvement of adventitious root formation in flax using hydrogen peroxide
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
Publication date: Available online 24 February 2016 Source:New Biotechnology Author(s): Tomáš Takáč, Bohuš Obert, Jakub Rolčík, Jozef Šamaj Flax (Linum usitatissimum L.) is an important crop for the production of oil and fiber. In vitro manipulations of flax are used for genetic improvement and breeding while improvements in adventitious root formation are important for biotechnological […]
Risk of breast cancer after false-positive results in mammographic screening
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
Abstract Women with false-positive results are commonly referred back to routine screening. Questions remain regarding their long-term outcome of breast cancer. We assessed the risk of screen-detected breast cancer in women with false-positive results. We conducted a joint analysis using individual level data from the population-based screening programs in Copenhagen and Funen in Denmark, Norway, […]
Sanford Head, Neck Cancer Clinical Trial Will Aim to Activate Immune System – Newswise (press release)
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
Sanford Head, Neck Cancer Clinical Trial Will Aim to Activate Immune System Newswise (press release) Newswise — SIOUX FALLS, S.D. – A new Sanford Health clinical trial will explore a drug’s ability to activate the body’s immune system to fight head and neck cancer. Oncologist and cancer researcher Steven Powell, M.D., developed and will lead […]
Animal venom study may lead to discovery of new drugs – BDlive
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
Animal venom study may lead to discovery of new drugs BDlive And that is precisely how the pharmaceutical industry could use these proteins: to produce new, more precise treatments with fewer side effects and to treat pain and illnesses such as diabetes, cancer and cardiovascular diseases. Of course, because of … from #ORL-AlexandrosSfakianakis via simeraentaxei […]
Interleukin-33 Expression Indicates a Favorable Prognosis in Malignant Salivary Gland Tumors
Interleukin-33 Expression Indicates a Favorable Prognosis in Malignant Salivary Gland Tumors: The cytokine interleukin-33 (IL-33) is abundantly expressed in epithelial barrier tissues such as salivary glands. Here, we characterized nuclear IL-33 protein expression by immunohistochemistry in benign and malignant salivary gland tumors and associated it with disease outcome. Most benign salivary gland tumors expressed IL-33, and all Warthin’s tumors showed strong and consistent IL-33 expression in the basally oriented cells of their bilayered epithelium. In the malignant group of neop... περισσότερα »
Incidence and risk factors for food hypersensitivity in infants
Incidence and risk factors for food hypersensitivity in UK infants: results from a birth cohort study: Kate E. C. GrimshawEmail authorView ORCID ID profile, Trevor Bryant, Erin M. Oliver, Jane Martin, Joe Maskell, Terri Kemp, E. N. Clare Mills, Keith D. Foote, Barrie M. Margetts, Kirsten Beyer and Graham Roberts Clinical and Translational Allergy20166:1 DOI: 10.1186/s13601-016-0089-8© Grimshaw et al. 2016 Received: 3 July 2015Accepted: 7 December 2015Published: 26 January 2016 Abstract Background The prevalence of food hypersensitivity in the UK is still largely open to ... περισσότερα »
Allergen immunotherapy for allergic asthma: protocol for a systematic review
*Allergen immunotherapy for allergic asthma: protocol for a systematic review: * *- Sangeeta DhamiEmail authorView ORCID ID profile, - Ulugbek Nurmatov, - Ioana Agache, - Susanne Lau, - Antonella Muraro, - Marek Jutel, - Graham Roberts, - Cezmi Akdis,- Matteo Bonini, - Moises Calderon, - Thomas Casale, - Ozlem Cavkaytar, - Linda Cox, - Pascal Demoly, - Breda Flood, - Eckard Hamelmann,- Kenji Izuhara, - Ömer Kalayci, - Jörg Kleine-Tebbe, - Antonio Nieto, - Nikolaos Papadopoulos, - Oliver Pfaar, - Lanny Rosenwasser, - Dermot Ryan,- Carsten Schmidt-Weber,... περισσότερα »
Allergen immunotherapy for insect venom allergy: protocol for a systematic review
*Allergen immunotherapy for insect venom allergy: protocol for a systematic review * *- Sangeeta DhamiEmail authorView ORCID ID profile, - Ulugbek Nurmatov, - Eva-Maria Varga, - Gunter Sturm, - Antonella Muraro, - Cezmi A. Akdis, - Darío Antolín-Amérigo,- M. Beatrice Bilò, - Danijela Bokanovic, - Moises A. Calderon, - Ewa Cichocka-Jarosz, - Joanna N. G. Oude Elberink, - Radoslaw Gawlik, - Thilo Jakob,- Mitja Kosnik, - Joanna Lange, - Ervin Mingomataj, - Dimitris I. Mitsias, - Holger Mosbech, - Oliver Pfaar, - Constantinos Pitsios, - Valerio Pravettoni,... περισσότερα »
High immunosuppressive burden in cancer patients: a major hurdle for cancer immunotherapy
High immunosuppressive burden in cancer patients: a major hurdle for cancer immunotherapy: AbstractA bottleneck for immunotherapy of cancer is the immunosuppressive microenvironment in which the tumor cells are located. Regardless of the fact that large numbers of tumor-specific T cells can be generated in patients by active immunization or adoptive transfer, these T cells do not readily translate to tumor cell killing in vivo. The immune regulatory mechanism that prevents autoimmunity may be harnessed by tumor cells for the evasion of immune destruction. Regulatory T cells, myeloi...περισσότερα »
Screening of Herbal-Based Bioactive Extract Against Carbapenem-Resistant Strain of Acinetobacter baumannii
Microbial Drug Resistance , Vol. 0, No. 0. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1WKpxbU via IFTTT
Novel window on early human neurodevelopment via fetal exosomes in maternal blood
Abstract Adverse in utero exposures can disrupt fetal brain development, deplete subpopulations of neurons and inhibit formation of normal synaptic connections. A major roadblock to unraveling the precise mechanisms and timing of human neurodevelopmental derangement is the almost complete absence of sensitive noninvasive assessments. We present novel methods for isolating fetal neuronal exosomes from maternal plasma as a noninvasive platform for testing aspects of fetal neurodevelopment as early as the 1st trimester. Our methodology represents an important breakthrough both in unde...περισσότερα »
High-throughput sequencing of immune repertoires in multiple sclerosis
Abstract T cells and B cells are crucial in the initiation and maintenance of multiple sclerosis (MS), and the activation of these cells is believed to be mediated through specific recognition of antigens by the T- and B-cell receptors. The antigen receptors are highly polymorphic due to recombination (T- and B-cell receptors) and mutation (B-cell receptors) of the encoding genes, which can therefore be used as fingerprints to track individual T- and B-cell clones. Such studies can shed light on mechanisms driving the immune responses and provide new insights into the pathogenesis.... περισσότερα »
Reply to comment on: A second trigeminal CGRP receptor: function and expression of the AMY1 receptor
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The Grooved Rodent Incisor Recapitulates Rudimentary Teeth Characteristics of Ancestral Mammals
It is known from the paleontology studies of eutherian mammals that incisor numbers were reduced during evolution. The evolutionary lost incisors may remain as vestigial structures at embryonic stages. The recapitulation of the incisor patterns among mammalian species will potentially uncover the mechanisms underlying the phenotypic transition of incisors during evolution. Here, we showed that a minute tooth formed in the presumptive groove region of the gerbil upper incisor at the early developmental stages, during which multiple epithelial swellings and *Shh* transcription domai... περισσότερα »
Epithelial Microvesicles Promote an Inflammatory Phenotype in Fibroblasts
Microvesicles (MVs) are extracellular vesicles secreted by various cell types that are involved in intercellular communication. We hypothesized that in human periodontal disease, the pocket epithelium releases MVs, which then modulate gene expression in the underlying fibroblasts to control periodontal inflammation. MVs were isolated from culture medium of gingival epithelial cells (GECs) treated with oral bacterial biofilm extract or left untreated. Biofilm treatment significantly increased MV release from the GECs. Mass spectrometry of GEC-MVs identified a total of 2,173 protein... περισσότερα »
Effective Expansion: Balance between Shrinkage and Hygroscopic Expansion
The purpose of this study was to investigate the relationship between hygroscopic expansion and polymerization shrinkage for compensation of polymerization shrinkage stresses in a restored tooth. One resin-modified glass-ionomer (RMGI) (Ketac Nano, 3M ESPE), 2 compomers (Dyract, Dentsply; Compoglass, Ivoclar), and a universal resin-based composite (Esthet•X HD, Dentsply) were tested. Volumetric change after polymerization ("total shrinkage") and during 4 wk of water storage at 37°C was measured using an optical method (*n* = 10). Post-gel shrinkage was measured during polymerizati...περισσότερα »
Directly Placed Restorative Materials: Review and Network Meta-analysis
For restoring cavitated dental lesions, whether carious or not, a large number of material combinations are available. We aimed to systematically review and synthesize data of comparative dental restorative trials. A systematic review was performed. Randomized controlled trials published between 2005 and 2015 were included that compared the survival of ≥2 restorative and/or adhesive materials (i.e., no need for restorative reintervention). Pairwise and Bayesian network meta-analyses were performed, with separate evaluations for cervical cavitated lesions and load-bearing posterior... περισσότερα »
Thrombin Activates Latent TGF{beta}1 via Integrin {alpha}v{beta}1 in Gingival Fibroblasts
Transforming growth factor β (TGFβ) regulates cell proliferation, differentiation, migration, apoptosis, and extracellular matrix production. It also plays a pivotal role in the pathogenesis of gingival overgrowth. Thrombin is a key player in tissue repair, remodeling, and fibrosis after an injury, and it exerts profibrotic effects by activating protease-activated receptors. Connective tissue growth factor (CTGF or CCN2) modulates cell adhesion, migration, proliferation, matrix production, and wound healing. It is overexpressed in many fibrotic disorders, including gingival overgr... περισσότερα »
Enamelin Directs Crystallite Organization at the Enamel-Dentine Junction
Enamel is an acellular material formed by the intricate process of amelogenesis. Disruption caused at the initial stages of development, by means of mutations in the *ENAM* gene encoding the enamelin protein, results in enamel hypoplasia. Little is known about the consequence of *ENAM* mutation on the enamel structure at a crystallographic level. The aim of this study was to characterize the structure of *ENAM-*mutated enamel to develop a deeper understanding of the role of enamelin protein during formation with regard to crystal organization. Synchrotron X-ray microdiffraction (S... περισσότερα »
Increased Apoptosis of Inflamed Odontoblasts Is Associated with CD47 Loss
Survival of odontoblasts during infection and inflammation determines prognosis of the dental pulp. CD47 is a "self"-label surface marker on viable cells. The aim of the present study is to investigate the interaction between CD47, autophagy, and apoptosis in inflamed human dental pulp and lipopolysaccharide (LPS)–treated mDPC6T cells. We identified activation of autophagy and apoptosis in the odontoblasts due to inflammation of the human dental pulp. Furthermore, downregulation of CD47 correlated with increased autophagy and apoptosis in dental pulp of the patients afflicted with... περισσότερα »
Dispatcher-assisted compression-only cardiopulmonary resuscitation provides best quality cardiopulmonary resuscitation by laypersons: A randomised controlled single-blinded manikin trial.
Dispatcher-assisted compression-only cardiopulmonary resuscitation provides best quality cardiopulmonary resuscitation by laypersons: A randomised controlled single-blinded manikin trial.: BACKGROUND: High-quality cardiopulmonary resuscitation (CPR) by laypersons is a key determinant of both outcome and survival for out-of-hospital cardiac arrest. Dispatcher-assisted CPR (telephone-CPR, T-CPR) increases the frequency and correctness of bystander-CPR but results in prolonged time to first chest compressions. However, it remains unclear whether instructions for rescue ventilation and/...περισσότερα »
Determination of the appropriate sizes of oropharyngeal airways in adults: correlation with external facial measurements: A randomised crossover study.
Determination of the appropriate sizes of oropharyngeal airways in adults: correlation with external facial measurements: A randomised crossover study.: BACKGROUND: Two external facial measurements have been recommended as reference criteria for estimating appropriate oropharyngeal airway sizes: the distances between the maxillary incisors to the angle of the mandible, and that from the corner of the mouth to the angle of the mandible. OBJECTIVE: To compare the two guidelines and to determine the optimal external facial measurements for the selection of an appropriately sized airway...περισσότερα »
Patients prone for postoperative delirium: preoperative assessment, perioperative prophylaxis, postoperative treatment.
Patients prone for postoperative delirium: preoperative assessment, perioperative prophylaxis, postoperative treatment.: Purpose of review: The aim of this study was to review current literature on identification of patients at risk for postoperative delirium (POD) and to summarize recent findings on prophylaxis and treatment. Recent findings: Age and preoperative cognitive impairment are among the most important risk factors of POD. POD is the result of a complex interplay of predisposing and precipitating factors. Thus, both prophylaxis and treatment require multicomponent interve... περισσότερα »
Transaural experiments and a revised duplex theory for the localization of low-frequency tones
Transaural experiments and a revised duplex theory for the localization of low-frequency tones: [image: cm_sbs_024_plain.png] The roles of interaural time difference(ITD) and interaural level difference (ILD) were studied in free-field source localization experiments for sine tones of low frequency (250–750 Hz). Experiments combined real-source trials with virtual trials created through transaural synthesis based on real-time ear canal measurements. Experiments showed the following: (1) The naturally occurring ILD is physically large enough to exert an influence on sound localizat... περισσότερα »
Insertion Depth in Cochlear Implantation and Outcome in Residual Hearing and Vestibular Function
Insertion Depth in Cochlear Implantation and Outcome in Residual Hearing and Vestibular Function: [image: image]Objectives: It has long been known that cochlear implantation may cause loss of residual hearing and vestibular function. Different insertion depths may cause varying degrees of intracochlear trauma in the apical region of the cochlea. The present study investigated the correlation between the insertion depth and postoperative loss of residual hearing and vestibular function. Design: Thirty-nine adults underwent unilateral cochlear implantation. One group received a Med-El...περισσότερα »
The Relation Between Child Versus Parent Report of Chronic Fatigue and Language/Literacy Skills in School-Age Children with Cochlear Implants
The Relation Between Child Versus Parent Report of Chronic Fatigue and Language/Literacy Skills in School-Age Children with Cochlear Implants: [image: image]Objectives: Preliminary evidence suggests that children with hearing loss experience elevated levels of chronic fatigue compared with children with normal hearing. Chronic fatigue is associated with decreased academic performance in many clinical populations. Children with cochlear implants as a group exhibit deficits in language and literacy skills; however, the relation between chronic fatigue and language and literacy skills f... περισσότερα »
Corneal-Reflection Eye-Tracking Technique for the Assessment of Horizontal Sound Localization Accuracy from 6 Months of Age
Corneal-Reflection Eye-Tracking Technique for the Assessment of Horizontal Sound Localization Accuracy from 6 Months of Age: [image: image]Objectives: The evaluation of sound localization accuracy (SLA) requires precise behavioral responses from the listener. Such responses are not always possible to elicit in infants and young children, and procedures for the assessment of SLA are time consuming. The aim of this study was to develop a fast, valid, and objective method for the assessment of SLA from 6 months of age. To this end, pupil positions toward spatially distributed continuou... περισσότερα »
The Audiometric and Mechanical Effects of Partial Ossicular Discontinuity
The Audiometric and Mechanical Effects of Partial Ossicular Discontinuity: [image: image]Objectives: Ossicular discontinuity may be complete, with no contact between the disconnected ends, or partial, where normal contact at an ossicular joint or along a continuous bony segment of an ossicle is replaced by soft tissue or simply by contact of opposing bones. Complete ossicular discontinuity typically results in an audiometric pattern of a large, flat conductive hearing loss. In contrast, in cases where otomicroscopy reveals a normal external ear canal and tympanic membrane, high-freq...περισσότερα »
Interleaved Processors Improve Cochlear Implant Patients’ Spectral Resolution
Interleaved Processors Improve Cochlear Implant Patients’ Spectral Resolution: [image: image]Objective: Cochlear implant patients have difficulty in noisy environments, in part, because of channel interaction. Interleaving the signal by sending every other channel to the opposite ear has the potential to reduce channel interaction by increasing the space between channels in each ear. Interleaving still potentially provides the same amount of spectral information when the two ears are combined. Although this method has been successful in other populations such as hearing aid users, i... περισσότερα »
Revealing Hearing Loss: A Survey of How People Verbally Disclose Their Hearing Loss
Revealing Hearing Loss: A Survey of How People Verbally Disclose Their Hearing Loss: [image: image] Objective: Hearing loss is the most common sensory deficit and congenital anomaly, yet the decision-making processes involved in disclosing hearing loss have been little studied. To address this issue, we have explored the phrases that adults with hearing loss use to disclose their hearing loss. Design: Since self-disclosure research has not focused on hearing loss-specific issues, we created a 15-question survey about verbally disclosing hearing loss. English speaking adults (>18 ye... περισσότερα »
Immediate and Short-Term Therapeutic Results Between Direction-Changing Positional Nystagmus with Short- and Long-Duration Groups
Immediate and Short-Term Therapeutic Results Between Direction-Changing Positional Nystagmus with Short- and Long-Duration Groups: [image: image]Objectives: Clinicians sometimes treat patients with relatively long-duration geotropic direction-changing positional nystagmus (DCPN), without latency. Recently, the concept of a “light cupula” in the lateral canal that reveals persistent geotropic DCPN has been introduced. In the present study, we investigated the immediate and short-term therapeutic findings in long-duration DCPN. Design: The authors prospectively compared the therapeuti...περισσότερα »
Asymmetric Hearing Loss in Chinese Workers Exposed to Complex Noise
Asymmetric Hearing Loss in Chinese Workers Exposed to Complex Noise: [image: image]Objectives: Evaluate the audiometric asymmetry in Chinese industrial workers and investigate the effects of noise exposure, sex, and binaural average thresholds on audiometric asymmetry. Design: Data collected from Chinese industrial workers during a cross-sectional study were reanalyzed. Of the 1388 workers, 266 met the inclusion criteria for this study. Each subject underwent a physical examination and an otologic examination and completed a health-related questionnaire. χ2 and t tests were used to ... περισσότερα »
Auditory Discrimination of Lexical Stress Patterns in Hearing-Impaired Infants with Cochlear Implants Compared with Normal Hearing: Influence of Acoustic Cues and Listening Experience to the Ambient Language
Auditory Discrimination of Lexical Stress Patterns in Hearing-Impaired Infants with Cochlear Implants Compared with Normal Hearing: Influence of Acoustic Cues and Listening Experience to the Ambient Language: [image: image]Objectives: To assess discrimination of lexical stress pattern in infants with cochlear implant (CI) compared with infants with normal hearing (NH). While criteria for cochlear implantation have expanded to infants as young as 6 months, little is known regarding infants’ processing of suprasegmental-prosodic cues which are known to be important for the first stage...περισσότερα »
Distribution Characteristics of Air-Bone Gaps: Evidence of Bias in Manual Audiometry
Distribution Characteristics of Air-Bone Gaps: Evidence of Bias in Manual Audiometry: [image: image]Objectives: Five databases were mined to examine distributions of air-bone gaps obtained by automated and manual audiometry. Differences in distribution characteristics were examined for evidence of influences unrelated to the audibility of test signals. Design: The databases provided air- and bone-conduction thresholds that permitted examination of air-bone gap distributions that were free of ceiling and floor effects. Cases with conductive hearing loss were eliminated based on air-b... περισσότερα »
Auditory Lexical Decision and Repetition in Children: Effects of Acoustic and Lexical Constraints
Auditory Lexical Decision and Repetition in Children: Effects of Acoustic and Lexical Constraints: [image: image]Objectives: The objective of this study was to identify factors that may detract from children’s ability to identify words they do and do not know. Factors investigated were acoustic constraints stemming from the presence of hearing loss (HL) or an acoustic competitor, and lexical constraints due to an impoverished or cluttered vocabulary. Design: Eleven children with normal hearing (NH) and 11 children with bilateral, mild to moderately severe sensorineural HL were asked... περισσότερα »
Text as a Supplement to Speech in Young and Older Adults
Text as a Supplement to Speech in Young and Older Adults: [image: image]Objective: The purpose of this experiment was to quantify the contribution of visual text to auditory speech recognition in background noise. Specifically, the authors tested the hypothesis that partially accurate visual text from an automatic speech recognizer could be used successfully to supplement speech understanding in difficult listening conditions in older adults, with normal or impaired hearing. The working hypotheses were based on what is known regarding audiovisual speech perception in the elderly from...περισσότερα »
Within- and Across-Subject Variability of Repeated Measurements of Medial Olivocochlear-Induced Changes in Transient-Evoked Otoacoustic Emissions
Within- and Across-Subject Variability of Repeated Measurements of Medial Olivocochlear-Induced Changes in Transient-Evoked Otoacoustic Emissions: [image: image]Objectives: Measurement of changes in transient-evoked otoacoustic emissions (TEOAEs) caused by activation of the medial olivocochlear reflex (MOCR) may have clinical applications, but the clinical utility is dependent in part on the amount of variability across repeated measurements. The purpose of this study was to investigate the within- and across-subject variability of these measurements in a research setting as a step ...περισσότερα »
Factors Predicting Postoperative Unilateral and Bilateral Speech Recognition in Adult Cochlear Implant Recipients with Acoustic Hearing
Factors Predicting Postoperative Unilateral and Bilateral Speech Recognition in Adult Cochlear Implant Recipients with Acoustic Hearing: [image: image]Objectives: The first objective was to examine factors that could be predictive of postoperative unilateral (cochlear implant alone) speech recognition ability in a group of subjects with greater degrees of preoperative acoustic hearing than has been previously examined. Second, the study aimed to identify factors predictive of speech recognition in the best-aided, bilateral listening condition. Design: Participants were 65 postlingui... περισσότερα »
The Benefits of a Multimedia Educational Program for First-Time Hearing Aid Users
A Randomized Controlled Trial to Evaluate the Benefits of a Multimedia Educational Program for First-Time Hearing Aid Users: [image: image]Objectives: The aims of this study were to (1) develop a series of short interactive videos (or reusable learning objects [RLOs]) covering a broad range of practical and psychosocial issues relevant to the auditory rehabilitation for first-time hearing aid users; (2) establish the accessibility, take-up, acceptability and adherence of the RLOs; and (3) assess the benefits and cost-effectiveness of the RLOs. Design: The study was a single-center, ... περισσότερα »
Effects of Reverberation and Compression on Consonant Identification in Individuals with Hearing Impairment
Effects of Reverberation and Compression on Consonant Identification in Individuals with Hearing Impairment: [image: image]Objectives: Hearing aids are frequently used in reverberant environments; however, relatively little is known about how reverberation affects the processing of signals by modern hearing-aid algorithms. The purpose of this study was to investigate the acoustic and behavioral effects of reverberation and wide-dynamic range compression (WDRC) in hearing aids on consonant identification for individuals with hearing impairment. Design: Twenty-three listeners with mil...περισσότερα »
Eliciting Cervical Vestibular-Evoked Myogenic Potentials by Bone-Conducted Vibration via Various Tapping Sites
Eliciting Cervical Vestibular-Evoked Myogenic Potentials by Bone-Conducted Vibration via Various Tapping Sites: [image: image]Objectives: This study compared bone-conducted vibration (BCV) cervical vestibular-evoked myogenic potentials (cVEMPs) via tapping at various skull sites in healthy subjects and patients with vestibular migraine (VM) to optimize stimulation conditions. Design: Twenty healthy subjects underwent a series of cVEMP tests by BCV tapping via a minishaker at the Fz (forehead), Cz (vertex), and inion (occiput) sites in a randomized order of tapping sites. Another 20 ...περισσότερα »
Working Memory, Compressor Speed, and Background Noise Characteristics
Exploring the Relationship Between Working Memory, Compressor Speed, and Background Noise Characteristics: [image: image] Objectives: Previous work has shown that individuals with lower working memory demonstrate reduced intelligibility for speech processed with fast-acting compression amplification. This relationship has been noted in fluctuating noise, but the extent of noise modulation that must be present to elicit such an effect is unknown. This study expanded on previous study by exploring the effect of background noise modulations in relation to compression speed and working... περισσότερα »
Human Frequency Following Response: Neural Representation of Envelope and Temporal Fine Structure in Listeners with Normal Hearing and Sensorineural Hearing Loss
Human Frequency Following Response: Neural Representation of Envelope and Temporal Fine Structure in Listeners with Normal Hearing and Sensorineural Hearing Loss: [image: image]Objective: Listeners with sensorineural hearing loss (SNHL) typically experience reduced speech perception, which is not completely restored with amplification. This likely occurs because cochlear damage, in addition to elevating audiometric thresholds, alters the neural representation of speech transmitted to higher centers along the auditory neuroaxis. While the deleterious effects of SNHL on speech percepti...περισσότερα »
Tinnitus And Musical Genius
Tinnitus And Musical Genius: Famed German composers Ludwig van Beethoven and Robert Schumann both suffered from tinnitus. Beethoven eventually went deaf, but in spite of his inability to hear, he went on to compose “Ode to Joy”, one of the most recognized pieces of classical music in Western history. In an article in *Psychology Today*, George Michelson Foy explores the link between tinnitus and musical genius, questioning whether Beethoven was able to compose his masterpieces in spite of tinnitus or *because* of it. *Can You Hear That?* According to Foy, our hearing organs are al...περισσότερα »
Prevalence and Outcomes of Head and Neck versus Non-Head and Neck Second Primary Malignancies in Head and Neck Squamous Cell Carcinoma: An Analysis of the Surveillance, Epidemiology, and End Results Database
Prevalence and Outcomes of Head and Neck versus Non-Head and Neck Second Primary Malignancies in Head and Neck Squamous Cell Carcinoma: An Analysis of the Surveillance, Epidemiology, and End Results Database: Background/Aims: Patients with head and neck squamous cell carcinoma (HNSCC) are at risk for second primary malignancies (SPMs). The prevalence, distribution, and patient survival in head and neck versus non-head and neck SPMs are not fully elucidated. The objective of this study was to quantify the rate of SPMs in patients with HNSCC. Methods: This is a population-based cohort... περισσότερα »
Video laryngoscopy during chest compressions
Video laryngoscopy during chest compressions: DALLAS — Advanced airway placement during cardiac arrest resuscitation may interrupt chest compressions and lead to excessive ventilations. Scott Youngquist, MD, the medical director for Salt Lake City, presented a process to implement video laryngoscopy and determine if VL could lead to less interruptions in chest compressions than direct laryngoscopy at the 2016 Gathering of Eagles XVIII EMS State of the Science program. The success of intubation with direct laryngoscopy and video laryngoscopy were reviewed. During the trial period th...περισσότερα »
Hearing loss and cognition in the Busselton Baby Boomer cohort: An epidemiological study
Hearing loss and cognition in the Busselton Baby Boomer cohort: An epidemiological study: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis To determine the relationship between peripheral hearing loss (HL) in baby boomers (better-ear measure) and cognitive function, taking into account the impact of depression or cognitive reserve on this relationship and exploring binaural hearing. Study Design A prospective, epidemiology study. Methods Data from 1,969 participants aged 45 to 66 years were collected in the Busselton Healthy Ageing Study. Participants were ... περισσότερα »
Immunmodulation als innovative Therapie bei Kopf-Hals-Tumoren
Immunmodulation als innovative Therapie bei Kopf-Hals-Tumoren: Zusammenfassung Das Plattenepithelkarzinom des Kopf-Hals-Bereichs (PKH) ist durch seine starke Immunsuppression und ausgeprägte Immune-escape-Mechanismen gekennzeichnet. Die immuntherapeutischen Ansätze gewinnen weiter an Bedeutung, wobei sich die Studienlandschaft deutlich in Richtung antikörperbasierter Immuncheckpointmodulation verschoben hat. Der Einsatz der Immuntherapie als kurativer Ansatz oder als Rezidivprophylaxe ist anzustreben. from #Med Blogs by… Continue reading Immunmodulation als innovative Therapie bei K... περισσότερα »
Risk of breast cancer after false-positive results in mammographic screening
Abstract Women with false-positive results are commonly referred back to routine screening. Questions remain regarding their long-term outcome of breast cancer. We assessed the risk of screen-detected breast cancer in women with false-positive results. We conducted a joint analysis using individual level data from the population-based screening programs in Copenhagen and Funen in Denmark, Norway,… Continue reading Risk of breast cancer after false-positive results in mammographic screening
Safety and Effectiveness of Total Thyroidectomy and Its Comparison with Subtotal Thyroidectomy and Other Thyroid Surgeries: A Systematic Review
Safety and Effectiveness of Total Thyroidectomy and Its Comparison with Subtotal Thyroidectomy and Other Thyroid Surgeries: A Systematic Review: Diseases associated with the thyroid gland are one of the most frequently seen endocrine disorders across the globe. Total thyroidectomy is currently the preferred treatment for many thyroid diseases. Controversies exist among surgeons regarding safety of… Continue reading Safety and Effectiveness of Total Thyroidectomy and Its Comparison with Subtotal Thyroidectomy and Other Thyroid Surgeries: A Systematic Review
Chronic Sclerosing Sialadenitis (Küttner’s Tumor)
Diagnostic Challenges in the Fine Needle Aspiration Biopsy of Chronic Sclerosing Sialadenitis (Küttner’s Tumor) in the Context of Head and Neck Malignancy: A Series of 4 Cases: Abstract Chronic sclerosing sialadenitis (CSS) is a benign chronic inflammatory condition of the salivary gland. Clinically, CSS patients may present with a neck mass, often suggesting a neoplastic… Continue reading Chronic Sclerosing Sialadenitis (Küttner’s Tumor)
Bacteria Other Than Helicobacter pylori in the Gastric Carcinogenesis
Analysis of Gastric Microbiota by Pyrosequencing: Minor Role of Bacteria Other Than Helicobacter pylori in the Gastric Carcinogenesis by Hyun Jin Jo, Jaeyeon Kim, Nayoung Kim, Ji Hyun Park, Ryoung Hee Nam, Yeong-Jae Seok, Yeon-Ran Kim, Joo Sung Kim, Jung Mogg Kim, Jung Min Kim, Dong Ho Lee, Hyun Chae Jung via Helicobacter Abstract Background… Continue reading Bacteria Other Than Helicobacter pylori in the Gastric Carcinogenesis
Endolaryngeal suture technique using a silicon piece
Endolaryngeal suture technique using a silicon piece: A fast and convenient method: *Suture *lateralization in patients *with *bilateral vocal fold paralysis WF Su, SC Liu, WS Tang, MC Yang, YY Lin, TT Huang - Journal of Voice, 2014 - Elsevier *...* The skin incision was then closed *with* *sutures*. *...* *with* traditional *techniques*, we observed that the successful rate of reinnervation procedures was low 3 and 14 and that *endolaryngeal* laser arytenoidectomy 4 or *...* (B) A maximal tie produces less vector force when the *suture* line is *...*
The superficial musculoaponeurotic system flap in the prevention of Frey syndrome: A meta-analysis
The superficial musculoaponeurotic system flap in the prevention of Frey syndrome: A meta-analysis: Objectives/Hypothesis Evaluate the difference of the incidence in clinical Frey syndrome in studies comparing classical parotidectomy and parotidectomy with superficial musculoaponeurotic system (SMAS) flap elevation and suturing through meta-analysis methodology. Study Design Meta-analysis of controlled studies with and without SMAS flap. Methods Database search with the following key word combination: “Frey syndrome” and “SMAS.” Inclusion criteria: parotidectomy, SMAS flap and contro... περισσότερα »
Racial differences in vestibular schwannoma
Racial differences in vestibular schwannoma: Objectives/Hypothesis To estimate the impact of race on disease presentation and treatment of vestibular schwannoma (VS) in the United States. Study Design Analysis of a national population-based tumor registry. Methods Analysis of the Surveillance, Epidemiology, and End Results database was performed, including all patients identified with a diagnosis of VS. Associations between race, disease presentation, treatment strategy, and overall survival were analyzed in a univariate and multivariable model. Results A total of 9,782 patients with ... περισσότερα »
Desensitization-resistant and -sensitive GPCR-mediated inhibition of GABA release occurs by Ca2+-dependent and -independent mechanisms at a hypothalamic synapse
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 18 δευτερόλεπτα
While the activation of Gαi/o-coupled receptors commonly results in postsynaptic responses that show acute desensitization, the presynaptic inhibition of transmitter release caused by many Gαi/o-coupled receptors is maintained during agonist exposure. However, an exception has been noted where GABAB receptor-mediated inhibition of inhibitory postsynaptic currents (IPSCs) recorded in mouse proopiomelanocortin (POMC) neurons exhibit acute desensitization in ~25% of experiments. To determine if differential effector coupling confers sensitivity to desensitization, voltage-clamp recor... περισσότερα »
Effects of GABAA kinetics on cortical population activity: Computational studies and physiological confirmations
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 18 δευτερόλεπτα
Voltage-Sensitive Dye (VSD) imaging produces an unprecedented real-time and high-resolution mesoscopic the cortical population activity. We have previously shown that the neuronal compartments contributions to the signal are dynamic and stimulus-dependent (Chemla and Chavane 2010a). Moreover, the VSD signal can also be strongly affected by the network state, such as in anesthetized vs. awake preparations. Here, we investigated the impact of the network state, through GABAA receptors modulation, on the VSD signal using a computational approach. We therefore measured systematically t... περισσότερα »
Large-scale imaging of cortical dynamics during sensory perception and behavior
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 18 δευτερόλεπτα
Sensory-driven behaviors engage a cascade of cortical regions to process sensory input and generate motor output. To investigate the temporal dynamics of neural activity at this global scale, we have developed methods to perform functional imaging across large areas of cortex using a transgenic mouse expressing GCaMP6s, integrated with a head-fixed visual discrimination behavior. This technique allows imaging of activity across the dorsal surface of cortex at a spatial resolution of approximately 50μm and temporal resolution of approximately 100 msec. Imaging during an orientation... περισσότερα »
A chronic neural interface to the macaque dorsal column nuclei
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 18 δευτερόλεπτα
The dorsal column nuclei (DCN) of the brainstem contain secondary afferent neurons, which process ascending somatosensory information. Most of the known physiology of the DCN in primates has been acquired in acute experiments with anesthetized animals. Here, we developed a technique to implant a multielectrode array (MEA) chronically in the DCN of macaque monkeys to enable experiments with the animals awake. Two monkeys were implanted with brainstem MEAs for 2-5 months with no major adverse effects. Responses of the cuneate and gracile nuclei were quantified at the level of both f... περισσότερα »
Determinants of racial differences in survival for sinonasal cancer
Determinants of racial differences in survival for sinonasal cancer: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis Racial differences in survival are present across multiple cancer types, including sinonasal cancer. Thus far in the literature, reasons for this have been theorized but not proven. We aimed to examine proposed potential factors and understand the true determinants in racial differences for survival in sinonasal cancer. Study Design Utilizing the U.S. National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER)-Medicare dat... περισσότερα »
Prospective Analysis of Robot-Assisted Surgery
Prospective Analysis of Robot-Assisted Surgery: *Conditions*: Esophageal Cancer; Gastric Cancer; Pancreatic Cancer; Rectal Cancer; Bladder Cancer; Prostate Cancer; Renal Cancer; Uterus Cancer; Head and Neck Cancer; Lung Cancer *Interventions*: Procedure: Robot-assisted surgery; Procedure: Conventional Surgery *Sponsor*: Instituto do Cancer do Estado de São Paulo The robot-assisted surgery allows three-dimensional view, detailed access of small structures, depth perception and articulated movements with wide latitude. Thinking about the inclusion of this ... περισσότερα »
MRI Iron Oxide Imaging for Lymph Node Staging in Esophageal Cancer
MRI Iron Oxide Imaging for Lymph Node Staging in Esophageal Cancer: *Condition*: Esophageal Cancer *Interventions*: Drug: Ferumoxytol; Device: MRI 3T scanner *Sponsors*: Dana-Farber Cancer Institute; AMAG Pharmaceuticals, Inc. ArmsAssigned Interventions Experimental: Ferumoxtyol (Feraheme) with MRI Patients will undergo a pre-contrast MRI followed by a pre determined dose of of IV Ferumoxyto. Post-contrast MRI imaging will be performed immediately following Ferumoxytol infusion and 48 hours after Ferumoxytol administration with subsequent image analysis. Drug: Ferumoxytol...περισσότερα »
Die konnatale Dakryostenose aus ophthalmologischer Sicht
Die konnatale Dakryostenose aus ophthalmologischer Sicht: Zusammenfassung HintergrundDie konnatale Dakryostenose (KDS) stellt eine der häufigsten kinderophthalmologischen Fragestellungen dar. Verschiedene Behandlungsoptionen stehen zur Verfügung und umfassen konservative sowie invasive Maßnahmen. Diese lassen sich in ein therapeutisches Stufenkonzept einordnen. FragestellungWie sieht das derzeit bei KDS anzuwendende therapeutische Stufenkonzept aus ophthalmologischer Sicht aus? MethodenIn diesem Übersichtsartikel wird auf die verschiedenen Formen der KDS eingegangen. Die be... περισσότερα »
Immunmodulation als innovative Therapie bei Kopf-Hals-Tumoren
Immunmodulation als innovative Therapie bei Kopf-Hals-Tumoren: ZusammenfassungDas Plattenepithelkarzinom des Kopf-Hals-Bereichs (PKH) ist durch seine starke Immunsuppression und ausgeprägte Immune-escape-Mechanismen gekennzeichnet. Die immuntherapeutischen Ansätze gewinnen weiter an Bedeutung, wobei sich die Studienlandschaft deutlich in Richtung antikörperbasierter Immuncheckpointmodulation verschoben hat. Der Einsatz der Immuntherapie als kurativer Ansatz oder als Rezidivprophylaxe ist anzustreben.
Safety and Effectiveness of Total Thyroidectomy and Its Comparison with Subtotal Thyroidectomy and Other Thyroid Surgeries: A Systematic Review
Safety and Effectiveness of Total Thyroidectomy and Its Comparison with Subtotal Thyroidectomy and Other Thyroid Surgeries: A Systematic Review: Diseases associated with the thyroid gland are one of the most frequently seen endocrine disorders across the globe. Total thyroidectomy is currently the preferred treatment for many thyroid diseases. Controversies exist among surgeons regarding safety of total thyroidectomy due to the risk associated with it like postoperative hypoparathyroidism or recurrent laryngeal nerve damage. Since, in the recent years, the incidence of thyroidectomy... περισσότερα »
Chronic Sclerosing Sialadenitis (Küttner’s Tumor)
Diagnostic Challenges in the Fine Needle Aspiration Biopsy of Chronic Sclerosing Sialadenitis (Küttner’s Tumor) in the Context of Head and Neck Malignancy: A Series of 4 Cases: AbstractChronic sclerosing sialadenitis (CSS) is a benign chronic inflammatory condition of the salivary gland. Clinically, CSS patients may present with a neck mass, often suggesting a neoplastic process. Fine-needle aspiration (FNA) is frequently used to evaluate these lesions. We present a series of 4 patients with CSS, in whom all but one had history of squamous cell carcinoma. The previous diagnosis of ...περισσότερα »
Bacteria Other Than Helicobacter pylori in the Gastric Carcinogenesis
Analysis of Gastric Microbiota by Pyrosequencing: Minor Role of Bacteria Other Than Helicobacter pylori in the Gastric Carcinogenesis by Hyun Jin Jo, Jaeyeon Kim, Nayoung Kim, Ji Hyun Park, Ryoung Hee Nam, Yeong-Jae Seok, Yeon-Ran Kim, Joo Sung Kim, Jung Mogg Kim, Jung Min Kim, Dong Ho Lee, Hyun Chae Jung via Helicobacter Abstract Background Little is known about the role of gastric microbiota except for *Helicobacter pylori* (HP) in human health and disease. We compared the differences of human gastric microbiota according to gastric cancer or control and HP infection status and asse... περισσότερα »
Effects of Round Window Opening Size and Moisturized Electrodes on Intracochlear Pressure Related to the Insertion of a Cochlear Implant Electrode
Effects of Round Window Opening Size and Moisturized Electrodes on Intracochlear Pressure Related to the Insertion of a Cochlear Implant Electrode: Intracochlear pressure changes during the cochlear implant insertion are assumed to be an important contributor to hearing preservation. The aim was to observe intracochlear pressure changes by different round window opening sizes and different hydrophilic electrode conditions. The experiments were performed in a cochlear model with a micropressure sensor in the helicotrema area. Different artificial round window membrane and different m...περισσότερα »
Pediatric central auditory processing disorder showing elevated threshold on pure tone audiogram
Pediatric central auditory processing disorder showing elevated threshold on pure tone audiogram: Central auditory processing disorder (CAPD) is a condition in which dysfunction in the central auditory system causes difficulty in listening to conversations, particularly under noisy conditions, despite normal peripheral auditory function. Central auditory testing is generally performed in patients with normal hearing on the pure tone audiogram (PTA). This report shows that diagnosis of CAPD is possible even in the presence of an elevated threshold on the PTA, provided that the normal... περισσότερα »
Salivary secretory leukocyte protease inhibitor (SLPI) and head and neck cancer
: The Cancer Prevention Study II Nutrition Cohort via ScienceDirect Publication: Oral Oncology Publication date: April 2016 *Source:*Oral Oncology, Volume 55 Author(s): Christine M. Pierce Campbell, Anna R. Giuliano, B. Nelson Torres, Michael T. O’Keefe, Donna J. Ingles, Rebecca L. Anderson, Lauren R. Teras, Susan M. Gapstur ObjectivesSecretory leukocyte protease inhibitor (SLPI) is an innate-immunity protein displaying antimicrobial and anti-inflammatory properties that is found in high concentrations in saliva. The role of extracellular salivary SLPI in head and neck squamous cell ca... περισσότερα »
Antithyroglobulin Antibody Concentrations Before and After Ablation with 131I
Comparison of Antithyroglobulin Antibody Concentrations Before and After Ablation with 131I as a Predictor of Structural Disease in Differentiated Thyroid Carcinoma Patients with Undetectable Basal Thyroglobulin and Negative Neck Ultrasonography: Thyroid , Vol. 0, No. 0. Author information Pedro Weslley Rosario,1,2 Marina Carvalho,1 Gabriela Franco Mourão,1,2 and Maria Regina Calsolari2 1Postgraduation Program, Santa Casa de Belo Horizonte, Minas Gerais, Brazil. 2Endocrinology Service, Santa Casa de Belo Horizonte, Minas Gerais, Brazil. Address correspondence to: *Pedro Weslley Rosá... περισσότερα »
SALUTE – Il sesso orale può condurre ai tumori della testa e del collo – Liveunict | Magazine sull’Università di Catania
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
Liveunict | Magazine sull’Università di Catania SALUTE – Il sesso orale può condurre ai tumori della testa e del collo Liveunict | Magazine sull’Università di Catania Sesso-orale-e–tumore-orofaringeo-trovato-un-pericoloso- Il sesso orale può condurre ai tumori della testa e del collo, oltre a quello già noto della gola. È quanto è stato dimostrato da una ricerca condotta […]
Aldosterone mediates metastatic spread of renal cancer via the G protein-coupled estrogen receptor (GPER) Research
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
Although aldosterone is a known regulator of renal and cardiovascular function, its role as a regulator of cancer growth and spread has not been widely considered. This study tested the hypothesis that aldosterone regulates cancer cell growth/spread via G protein–coupled estrogen receptor (GPER) activation. In vitro in murine renal cortical adenocarcinoma (RENCA) cells, a widely […]
Comparison of Antithyroglobulin Antibody Concentrations Before and After Ablation with 131I as a Predictor of Structural Disease in Differentiated Thyroid Carcinoma Patients with Undetectable Basal Thyroglobulin and Negative Neck Ultrasonography
Thyroid , Vol. 0, No. 0. from thyroid via a.lsfakia on Inoreader http://ift.tt/1OwcGUI via IFTTT
Clinical Presentation of Oropharyngeal Squamous Cell Carcinoma in the Modern Era: Does Risk Stratification Using Human Papillomavirus and Smoking Status Matter?
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Patterns of cervical lymph node metastases (LNMs) in patients with oropharyngeal squamous cell carcinoma (OPSCC) have historically been described. Here we compare the distribution of cervical LNMs in the human papillomavirus (HPV) era to historical controls. We also evaluated the influence of HPV and smoking status on the clinical presentation of OPSCC. (Source: International Journal of Radiation Oncology * Biology * Physics) from squamous cell carcinoma via ok on Inoreader http://ift.tt/1LegoHL via IFTTT
Novel insights into early neuroanatomical evolution in penguins from the oldest described penguin brain endocast
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Digital methodologies for rendering the gross morphology of the brain from X-ray computed tomography data have expanded our current understanding of the origin and evolution of avian neuroanatomy and provided new perspectives on the cognition and behavior of birds in deep time. However, fossil skulls germane to extracting digital endocasts from early stem members […]
Prevalent diabetes mellitus in patients with heart failure and disease determinants in sub-Saharan Africans having diabetes with heart failure: a protocol for a systematic review and meta-analysis
Introduction Heart failure (HF) is the final common pathway for most cardiovascular disease (CVDs). Diabetes mellitus (DM) is a major contributor to CVD burden and an independent predictor of mortality in patients with HF. However, the epidemiology of DM in African patients with HF is less well described. The current proposal is for a systematic… Continue reading Prevalent diabetes mellitus in patients with heart failure and disease determinants in sub-Saharan Africans having diabetes with heart failure: a protocol for a systematic review and meta-analysis
Scientists Discover Vessels That Connect The Immune System & Brain – Collective Evolution
Scientists Discover Vessels That Connect The Immune System & Brain Collective Evolution “We fooled ourselves into thinking the genome was going to be a transparent blueprint, but it’s not,” Mel Greaves, cell biologist at the Institute of Cancer Research stated. We also believed that chemicals could only harm us in large doses, yet … from… Continue reading Scientists Discover Vessels That Connect The Immune System & Brain – Collective Evolution
Donor Sibling Networks as a Vehicle for Expanding Kinship: A Replication and Extension
This article replicates an earlier study of mothers who had used the same sperm donor to conceive their children and connected through the Internet. The original study finds that these groups interact mainly on the Internet; donor siblings are latent affiliations that could answer questions about the paternal side. This new study of 2,217 parents… Continue reading Donor Sibling Networks as a Vehicle for Expanding Kinship: A Replication and Extension
Predicting the outcome of hip fracture patients by using N-terminal fragment of pro-B-type natriuretic peptide
Objective To examine the prognostic value of perioperative N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) in hip fracture patients. Design Blinded prospective cohort study. Setting Single centre trial at Turku University Hospital in Finland. Participants Inclusion criterion was admittance to the study hospital due to hip fracture during the trial period of October 2009—May 2010.… Continue reading Predicting the outcome of hip fracture patients by using N-terminal fragment of pro-B-type natriuretic peptide
Development of the Chinese version of the Hospital Autonomy Questionnaire: a cross-sectional study in Guangdong Province
Objective We aimed to develop a questionnaire for quantitative evaluation of the autonomy of public hospitals in China. Method An extensive literature review was conducted to select possible items for inclusion in the questionnaire, which was then reviewed by 5 experts. After a two-round Delphi method, we distributed the questionnaire to 404 secondary and tertiary… Continue reading Development of the Chinese version of the Hospital Autonomy Questionnaire: a cross-sectional study in Guangdong Province
Multiple lifestyle behaviours and overweight and obesity among children aged 9-11 years: results from the UK site of the International Study of Childhood Obesity, Lifestyle and the Environment
Objectives The purpose of this study was to explore the independent associations between multiple lifestyle behaviours (physical activity, sleep, screen time (ST) and diet) and overweight and obesity in UK children. The second objective was to compare body mass index (BMI) z-score between children who meet health guidelines for each lifestyle behaviour and those who… Continue reading Multiple lifestyle behaviours and overweight and obesity among children aged 9-11 years: results from the UK site of the International Study of Childhood Obesity, Lifestyle and the Environment
Secular trends for age at spermarche among Chinese boys from 11 ethnic minorities, 1995-2010: a multiple cross-sectional study
Objectives We compared the differences in median age at spermarche among 11 ethnic minorities in 2010, estimated the trends regarding age at spermarche in different ethnic minorities from 1995 to 2010, and explored the association of spermarche with body mass index (BMI). Methods We used four cross-sectional Chinese National Surveys on Students’ Constitution and Health… Continue reading Secular trends for age at spermarche among Chinese boys from 11 ethnic minorities, 1995-2010: a multiple cross-sectional study
SGLT-2 receptor inhibitors for treating patients with type 2 diabetes mellitus: a systematic review and network meta-analysis
Objective Because of the lack of head-to-head trials, the aim was to indirectly compare sodium glucose transporter-2 (SGLT-2) inhibitors in the treatment of type 2 diabetes. Design Systematic review and network meta-analysis. Data sources MEDLINE and EMBASE were searched from January 2005 to January 2015. Eligibility criteria Randomised controlled trials assessing the efficacy of SGLT-2… Continue reading SGLT-2 receptor inhibitors for treating patients with type 2 diabetes mellitus: a systematic review and network meta-analysis
Salivary secretory leukocyte protease inhibitor (SLPI) and head and neck cancer: The Cancer Prevention Study II Nutrition Cohort
Publication date: April 2016 Source:Oral Oncology, Volume 55 Author(s): Christine M. Pierce Campbell, Anna R. Giuliano, B. Nelson Torres, Michael T. O’Keefe, Donna J. Ingles, Rebecca L. Anderson, Lauren R. Teras, Susan M. Gapstur ObjectivesSecretory leukocyte protease inhibitor (SLPI) is an innate-immunity protein displaying antimicrobial and anti-inflammatory properties that is found in high concentrations in… Continue reading Salivary secretory leukocyte protease inhibitor (SLPI) and head and neck cancer: The Cancer Prevention Study II Nutrition Cohort
Cost-efficiency of specialist inpatient rehabilitation for working-aged adults with complex neurological disabilities: a multicentre cohort analysis of a national clinical data set
Objectives To evaluate functional outcomes, care needs and cost-efficiency of specialist rehabilitation for a multicentre cohort of inpatients with complex neurological disability, comparing different diagnostic groups across 3 levels of dependency. Design A multicentre cohort analysis of prospectively collected clinical data from the UK Rehabilitation Outcomes Collaborative (UKROC) national clinical database, 2010–2015. Setting All 62… Continue reading Cost-efficiency of specialist inpatient rehabilitation for working-aged adults with complex neurological disabilities: a multicentr... περισσότερα »
Auditory Discrimination of Lexical Stress Patterns in Hearing-Impaired Infants with Cochlear Implants Compared with Normal Hearing: Influence of Acoustic Cues and Listening Experience to the Ambient Language
[image: image]Objectives: To assess discrimination of lexical stress pattern in infants with cochlear implant (CI) compared with infants with normal hearing (NH). While criteria for cochlear implantation have expanded to infants as young as 6 months, little is known regarding infants' processing of suprasegmental-prosodic cues which are known to be important for the first stages of language acquisition. Lexical stress is an example of such a cue, which, in hearing infants, has been shown to assist in segmenting words from fluent speech and in distinguishing between words that differ... περισσότερα »
Asymmetric Hearing Loss in Chinese Workers Exposed to Complex Noise
[image: image]Objectives: Evaluate the audiometric asymmetry in Chinese industrial workers and investigate the effects of noise exposure, sex, and binaural average thresholds on audiometric asymmetry. Design: Data collected from Chinese industrial workers during a cross-sectional study were reanalyzed. Of the 1388 workers, 266 met the inclusion criteria for this study. Each subject underwent a physical examination and an otologic examination and completed a health-related questionnaire. χ2 and t tests were used to examine the differences between the asymmetric and symmetric hearing ...περισσότερα »
Immediate and Short-Term Therapeutic Results Between Direction-Changing Positional Nystagmus with Short- and Long-Duration Groups
[image: image]Objectives: Clinicians sometimes treat patients with relatively long-duration geotropic direction-changing positional nystagmus (DCPN), without latency. Recently, the concept of a "light cupula" in the lateral canal that reveals persistent geotropic DCPN has been introduced. In the present study, we investigated the immediate and short-term therapeutic findings in long-duration DCPN. Design: The authors prospectively compared the therapeutic efficacy of a canalith-repositioning procedure (CRP) in short- and long-duration geotropic DCPN. Results: In patients with long-d...περισσότερα »
Intracellular soluble alpha Synuclein oligomers reduce pyramidal cell excitability
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract The presynaptic protein alpha-Synuclein (αSyn) aggregates during Parkinson's disease (PD) to form large proteinaceous amyloid plaques, the spread of which throughout the brain clinically defines the severity of the disease. During early stages of aggregation, αSyn forms soluble annular oligomers that show greater toxicity than much larger fibrils. These oligomers produce toxicity through a number of possible mechanisms including the production of pore-forming complexes that permeabilise membranes. In this study, two well-defined species of soluble αSyn oligomers were prod...περισσότερα »
Screening of Herbal-Based Bioactive Extract Against Carbapenem-Resistant Strain of Acinetobacter baumannii
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Microbial Drug Resistance , Vol. 0, No. 0. from Mary Ann Liebert, Inc. publishers via xlomafota13 on Inoreader http://ift.tt/1KMtbkS via IFTTT
Gelam honey potentiates ex vivo corneal keratocytes proliferation with desirable phenotype expression
This study aimed to evaluate the effects of Gelam honey on corneal keratocytes proliferative capacity and phenotypic characterization via MTT assay, gene expression and immunocytochemistry. from #Medicine via ola Kala on Inoreader http://ift.tt/1Q27iNt Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Evaluation of Hepatoprotective activity of Eriocaulon quinquangulare in vitro using porcine liver slices against ethanol induced liver toxicity and free radical scavenging capacity
Production of reactive oxygen species is a common cause in alcohol induced liver diseases. Decoction prepared from the whole plant of Eriocaulon quinquingulare is prescribed to treat liver disorders. The aim of t... from #Medicine via ola Kala on Inoreader http://ift.tt/1oIzZ9w Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Reasons for continuing use of Complementary and Alternative Medicine (CAM) in students: a consumer commitment model
Research on continued CAM use has been largely atheoretical and has not considered the broader range of psychological and behavioral factors that may be involved. The purpose of this study was to test a new co... from #Medicine via ola Kala on Inoreader http://ift.tt/1Q27iNl Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Long-term exercise-specific neuroprotection in Spinal Muscular Atrophy-like mice
Abstract Spinal Muscular Atrophy (SMA) is a group of autosomal recessive neurodegenerative diseases differing in their clinical outcome, characterized by the specific loss of spinal motor neurons, caused by insufficient level of SMN protein expression. No cure is presently available for SMA. While physical exercise might represent a promising approach for alleviating SMA symptoms, the lack of data dealing with the effects of different exercise types on diseased motor units still precludes the use of active physiotherapy in SMA patients. In the present study, we have evaluated the ... περισσότερα »
Tinnitus And Musical Genius
Famed German composers Ludwig van Beethoven and Robert Schumann both suffered from tinnitus. Beethoven eventually went deaf, but in spite of his inability to hear, he went on to compose "Ode to Joy", one of the most recognized pieces of classical music in Western history. In an article in *Psychology Today*, George Michelson Foy explores the link between tinnitus and musical genius, questioning whether Beethoven was able to compose his masterpieces in spite of tinnitus or *because* of it. *Can You Hear That?* According to Foy, our hearing organs are always creating a faint noise, ...περισσότερα »
Nanoporous Au-based chronocoulometric aptasensor for amplified detection of Pb2+ using DNAzyme modified with Au nanoparticles
[image: S09565663.gif] Publication date: 15 July 2016 *Source:*Biosensors and Bioelectronics, Volume 81 Author(s): Chen Zhang, Cui Lai, Guangming Zeng, Danlian Huang, Lin Tang, Chunping Yang, Yaoyu Zhou, Lei Qin, Min Cheng The authors herein described an amplified detection strategy employing nanoporous Au (NPG) and gold nanoparticles (AuNPs) to detect Pb2+ ions in aqueous solution. The thiol modified Pb2+-specific DNAzyme was self-assembled onto the surface of the NPG modified electrode for hybridizing with the AuNPs labeled oligonucleotide and for forming the DNA double helix stru...περισσότερα »
Quantification of cooperativity in heterodimer-DNA binding improves the accuracy of binding specificity models Computational Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Many transcription factors (TFs) have the ability to cooperate on DNA elements as heterodimers. Despite the significance of TF heterodimerization for gene regulation, a quantitative understanding of cooperativity between various TF dimer partners and its impact on heterodimer DNA binding specificity models is still lacking. Here, we used a novel integrative approach, combining microfluidics-steered measurements […]
An Essential Role for Cdc42 in the Functioning of the Adult Mammary Gland Cell Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Rho family small GTPase Cdc42 has been implicated in a wide range of cellular functions including the establishment of cell polarity and the remodeling of the actin cytoskeletal architecture, resulting in the tight regulation of cell growth and survival during developmental processes. The complete knock-out of Cdc42 in the mouse is embryonic-lethal, and its […]
Allosteric Inhibition of Bcr-Abl Kinase by High-Affinity Monobody Inhibitors Directed to the SH2-Kinase Interface Signal Transduction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Bcr-Abl is a constitutively active kinase that causes chronic myelogenous leukemia (CML). We have shown that a tandem fusion of two designed binding proteins, termed monobodies, respectively directed to the interaction interface between the SH2 and kinase domains and to the phosphotyrosine-binding site of the SH2 domain inhibits the of Bcr-Abl kinase activity. Because the […]
TORC2-Gad8 is found in the nucleus where it interacts with the MBF transcriptional complex to regulate the response to DNA replication stress. Signal Transduction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Target of Rapamycin (TOR) kinase is found at the core of two evolutionarily conserved complexes, known as TOR complexes 1 and 2 (TORC1 and TORC2). In fission yeast, TORC2 is dispensable for proliferation under optimal growth conditions but is required for starvation and stress responses. We have previously reported that loss of function of […]
SIRT3 regulates {alpha}-SMA production through the succinate dehydrogenase-GPR91 pathway in hepatic stellate cells Metabolism
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Sirtuin 3 (SIRT3) is an NAD+-dependent protein deacetylase. Recent studies have shown that SIRT3 expression is decreased in nonalcoholic fatty liver disease (NAFLD). Moreover, SIRT3 is a key regulator of succinate dehydrogenase (SDH), which catalyzes the oxidation of succinate to fumarate. Increased succinate concentrations and the specific G protein-coupled receptor 91 (GPR91) are involved in […]
Transcriptional reprogramming and resistance to colonic mucosal injury in Poly(ADP-ribose) polymerase 1 (PARP1)-deficient mice Immunology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Poly(ADP-ribose) polymerases (PARPs) synthesize and bind branched polymers of ADP-ribose to acceptor proteins using NAD as a substrate, and participate to the control of gene transcription and DNA repair. PARP1, the most abundant isoform, regulates the expression of proinflammatory mediator – cytokines, chemokines and adhesion molecules, and inhibition of PARP1 enzymatic activity reduced or ameliorated […]
Plasmacytoid-Type Cellular Differentiation in Polymorphous Low-Grade Adenocarcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Introduction. Polymorphous low-grade adenocarcinoma (PLGA) occurs more frequently in minor salivary glands. The diagnosis of PLGA, in general, is not difficult but in occasional tumors showing limited invasion or in small biopsy specimens, PLGA may be confused with cellular pleomorphic adenoma (PA). Plasmacytoid cells, a usual component of PAs, have been considered helpful for correct […]
Recruitment strategies and challenges in a large intervention trial: Systolic Blood Pressure Intervention Trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: The Systolic Blood Pressure Intervention Trial is a multicenter, randomized clinical trial of 9361 participants with hypertension who are ≥50 years old. The trial is designed to evaluate the effect of intensive systolic blood pressure control (systolic blood pressure goal <120 mm Hg) compared to standard control (systolic blood pressure goal <140 mm Hg) […]
Masthead
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:The Journal of Pediatrics, Volume 170 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1oIQ5jr via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
50 Years Ago in The Journal of Pediatrics
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:The Journal of Pediatrics, Volume 170 Author(s): Sarah S. Long from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R34mxN via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Information for Readers
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:The Journal of Pediatrics, Volume 170 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1oIQ3rG via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
50 Years Ago in The Journal of Pediatrics
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:The Journal of Pediatrics, Volume 170 Author(s): Philip Toltzis from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R34oFL via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Nerve injury associated with orthognathic surgery. Part 2: inferior alveolar nerve
The inferior alveolar nerve (IAN) is the most commonly injured structure during mandibular osteotomies. The prevalence of temporary injury has been reported as 70/100 patients (95% CI 67 to 73/100) or 56/100 nerves (95% CI 46 to 65/100), and the prevalence of permanent alteration in sensation was 33/100 patients (95% CI 30 to 35/100) or 20/100 nerves (95% CI 18 to 21/100) when assessed subjectively. The prevalence varied significantly between different operations (p<0.0001). It was significantly higher for sagittal split osteotomy (SSO) combined with genioplasty than for SSO alone ... περισσότερα »
Customised bite blocks
Taking patients off mechanical ventilation has been associated with recurrent biting of endotracheal tubes,1 and alternatives to oral intubation such as nasal intubation or tracheostomy may not always be appropriate. Recently, three patients who were being weaned off the ventilator were referred to our team after biting the tubes, which caused serious difficulties with their treatment and anaesthesia. Conventional McKeeson bite blocks were easily dislodged and difficult to retrieve, which distressed the staff and the patient, so we made new ones. from #ΓναθοΧειρουργική via xlomafo... περισσότερα »
Delayed death caused by haematoma after manual strangulation: a rare case
We report the case of a 58-year-old man who had an altercation with his neighbour after drinking. He was seized by the neck, and although he did not complain of any discomfort at the time, he was found dead two hours later. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1LGQ83X via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Suitability of the Patient Concerns Inventory as a holistic screening tool in routine head and neck cancer follow-up clinics
In patients with cancer of the head and neck, efficient screening for problems can improve care and the management of resources. We explored use of the Patient Concerns Inventory (PCI-HN) as a holistic screening tool in the follow up of these patients. Between August 2007 and January 2013, 464 patients completed the PCI-HN and the University of Washington Quality of Life questionnaire version 4 (UWQoL) immediately before their routine follow-up consultations. The median (IQR) number of items selected on the inventory was 3 (1-6). from #ΓναθοΧειρουργική via xlomafota13 on Inoreader... περισσότερα »
Salivary secretory leukocyte protease inhibitor (SLPI) and head and neck cancer: The Cancer Prevention Study II Nutrition Cohort
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: April 2016 *Source:*Oral Oncology, Volume 55 Author(s): Christine M. Pierce Campbell, Anna R. Giuliano, B. Nelson Torres, Michael T. O'Keefe, Donna J. Ingles, Rebecca L. Anderson, Lauren R. Teras, Susan M. Gapstur ObjectivesSecretory leukocyte protease inhibitor (SLPI) is an innate-immunity protein displaying antimicrobial and anti-inflammatory properties that is found in high concentrations in saliva. The role of extracellular salivary SLPI in head and neck squamous cell carcinoma (HNSCC) remains unclear. Thus, we aimed to evaluate the association between SLPI an...περισσότερα »
Novel insights into early neuroanatomical evolution in penguins from the oldest described penguin brain endocast
Abstract Digital methodologies for rendering the gross morphology of the brain from X-ray computed tomography data have expanded our current understanding of the origin and evolution of avian neuroanatomy and provided new perspectives on the cognition and behavior of birds in deep time. However, fossil skulls germane to extracting digital endocasts from early stem members of extant avian lineages remain exceptionally rare. Data from early-diverging species of major avian subclades provide key information on ancestral morphologies in Aves and shifts in gross neuroanatomical structu... περισσότερα »
Vascular Aneurysm Secondary to a Femoral Intertrochanteric Fracture Concealed by Anticoagulation Therapy.
Related Articles Vascular Aneurysm Secondary to a Femoral Intertrochanteric Fracture Concealed by Anticoagulation Therapy. Isr Med Assoc J. 2015 Dec;17(12):777-9 Authors: Luria S, Eylon S, Peyser A PMID: 26897982 [PubMed – in process] from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/21sIYcu via IFTTT
Long-term exercise-specific neuroprotection in Spinal Muscular Atrophy-like mice
Abstract Spinal Muscular Atrophy (SMA) is a group of autosomal recessive neurodegenerative diseases differing in their clinical outcome, characterized by the specific loss of spinal motor neurons, caused by insufficient level of SMN protein expression. No cure is presently available for SMA. While physical exercise might represent a promising approach for alleviating SMA symptoms, the… Continue reading Long-term exercise-specific neuroprotection in Spinal Muscular Atrophy-like mice
Non-Radiographic Axial Spondyloarthritis.
Related Articles Non-Radiographic Axial Spondyloarthritis. Isr Med Assoc J. 2015 Dec;17(12):770-6 Authors: Slobodin G, Eshed I Abstract The term non-radiographic axial spondyloarthritis (nrAxSpA) was coined for patients who have a clinical picture of ankylosing spondylitis (AS) but do not exhibit radiographic sacroiliitis. The ASAS classification criteria for nrAxSpA, ensuring the recruitment of homogenous study cohorts,… Continue reading Non-Radiographic Axial Spondyloarthritis.
50 Years Ago in The Journal of Pediatrics
Publication date: March 2016 Source:The Journal of Pediatrics, Volume 170 Author(s): Philip Toltzis from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R34oFL via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SW5IjE via IFTTT
The Road to Modified D2 Gastrectomy.
Related Articles The Road to Modified D2 Gastrectomy. Isr Med Assoc J. 2015 Dec;17(12):768-9 Authors: Avital S, Shpitz B PMID: 26897980 [PubMed – in process] from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/21sIVgR via IFTTT
Tinnitus And Musical Genius
Famed German composers Ludwig van Beethoven and Robert Schumann both suffered from tinnitus. Beethoven eventually went deaf, but in spite of his inability to hear, he went on to compose «Ode to Joy», one of the most recognized pieces of classical music in Western history. In an article in Psychology Today, George Michelson Foy explores… Continue reading Tinnitus And Musical Genius
Non-Valvular Findings before Trans-Catheter Aortic Valve Implantation and their Impact on the Procedure.
Related Articles Non-Valvular Findings before Trans-Catheter Aortic Valve Implantation and their Impact on the Procedure. Isr Med Assoc J. 2015 Dec;17(12):764-7 Authors: Goitein O, Di Segni E, Eshet Y, Guetta V, Segev A, Nahum E, Raanani E, Konen E, Hamdan A Abstract UNLABELLED: Background: Trans-cathetervalve implantation (TAVI) is a non- surgical alternative for patients with… Continue reading Non-Valvular Findings before Trans-Catheter Aortic Valve Implantation and their Impact on the Procedure.
Incidence of Implantable Cardioverter Defibrillator Therapy and Mortality in Primary and Secondary Prevention of Sudden Cardiac Death.
Related Articles Incidence of Implantable Cardioverter Defibrillator Therapy and Mortality in Primary and Secondary Prevention of Sudden Cardiac Death. Isr Med Assoc J. 2015 Dec;17(12):760-3 Authors: Konstantino Y, Shafat T, Novack V, Novack L, Amit G Abstract BACKGROUND: Implantable cardioverter defibrillators (ICDs) reduce mortality in patients implanted for primary and secondary prevention of sudden cardiac… Continue reading Incidence of Implantable Cardioverter Defibrillator Therapy and Mortality in Primary and Secondary Prevention of Sudden Cardiac Death.
A Validated Method for Identifying Unplanned Pediatric Readmission
Publication date: March 2016 Source:The Journal of Pediatrics, Volume 170 Author(s): Katherine A. Auger, Emily L. Mueller, Steven H. Weinberg, Catherine S. Forster, Anita Shah, Christine Wolski, Grant Mussman, Anna J. Ipsaro, Matthew M. Davis ObjectiveTo validate the accuracy of pre-encounter hospital designation as a novel way to identify unplanned pediatric readmissions and describe the… Continue reading A Validated Method for Identifying Unplanned Pediatric Readmission
Establishment of a Registry to Monitor Trends in Cataract Surgical Procedures and Outcomes in Israel, 1990-2014.
Related Articles Establishment of a Registry to Monitor Trends in Cataract Surgical Procedures and Outcomes in Israel, 1990-2014. Isr Med Assoc J. 2015 Dec;17(12):755-9 Authors: Abulafia A, Rosen E, Assia EI, Kleinmann G Abstract BACKGROUND: Cataract extraction is the most commonly performed ophthalmic surgical procedure. There is no registry for documenting cataract surgical procedures and… Continue reading Establishment of a Registry to Monitor Trends in Cataract Surgical Procedures and Outcomes in Israel, 1990-2014.
Choline-induced selective fluorescence quenching of acetylcholinesterase conjugated Au@BSA clusters
[image: S09565663.gif] Publication date: 15 July 2016 *Source:*Biosensors and Bioelectronics, Volume 81 Author(s): Meegle S. Mathew, Ananya Baksi, T. Pradeep, Kuruvilla Joseph We have developed a highly selective sensitive fluorescent detection of acetylcholine (ACh) using bovine serum albumin (BSA) protected atomically precise clusters of gold. The gold quantum clusters (AuQC@BSA) synthesized using bovine serum albumin and conjugated with acetylcholinesterase (AChE), an enzyme specific for acetylcholine, resulting in AuQC@BSA-AChE. The enzyme, AChE hydrolyzes acetylcholine (ACh) to ... περισσότερα »
A highly sensitive and selective impedimetric aptasensor for interleukin-17 receptor A
[image: S09565663.gif] Publication date: 15 July 2016 *Source:*Biosensors and Bioelectronics, Volume 81 Author(s): Hunho Jo, Seong-Kyeong Kim, Hyungjun Youn, Heehyun Lee, Kwanghyun Lee, Jian Jeong, Jihyun Mok, Seung-Hyun Kim, Hae-Sim Park, Changill Ban Interleukin-17 receptor A (IL-17RA) has been recognized as a valuable biomarker for diverse diseases, including autoimmune diseases. In this work, an electrochemical biosensor with great sensitivity and selectivity toward IL-17RA was fabricated using an IL-17RA aptamer (Kd=14.00nM) for the first time. The aptasensor was manufactured u... περισσότερα »
Bacteria counting method based on polyaniline/bacteria thin film
[image: S09565663.gif] Publication date: 15 July 2016 *Source:*Biosensors and Bioelectronics, Volume 81 Author(s): Li Zhihua, Hu Xuetao, Shi Jiyong, Zou Xiaobo, Huang Xiaowei, Zhou Xucheng, Haroon Elrasheid Tahir, Mel Holmes, Malcolm Povey A simple and rapid bacteria counting method based on polyaniline (PANI)/bacteria thin film was proposed. Since the negative effects of immobilized bacteria on the deposition of PANI on glass carbon electrode (GCE), PANI/bacteria thin films containing decreased amount of PANI would be obtained when increasing the bacteria concentration. The prepared...περισσότερα »
Venous thromboembolism in a patient with persistent inhibitor to coagulation factor V – a case report
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1T8iIDh via IFTTT
