Adverse event potentially due to an interaction between ibrutinib and verapamil: a case report
Adverse event potentially due to an interaction between ibrutinib and verapamil: a case report: Summary What is known and objective Ibrutinib is a recently approved oral anticancer agent with pharmacokinetics that is very sensitive to metabolic inhibition. We report a serious side effect of ibrutinib potentially attributable to interaction with the moderate CYP3A4 inhibitor verapamil. Case description A patient with mantle cell lymphoma was admitted to our emergency department with severe diarrhoea. During a prescription review, the clinical pharmacist identified a potential drug in... περισσότερα »
Who uses pharmacy for flu vaccinations?
Who uses pharmacy for flu vaccinations? Population profiling through a UK pharmacy chain: Abstract*Background* There is a need to increase influenza vaccination rates in England particularly among those who are under 65 years of age and at-risk because of other conditions and treatments. *Objective* To understand the profile of people accessing flu vaccination services within a large pharmacy chain. *Method* Pharmacists requested people who had been vaccinated in 2014/15 to complete a questionnaire. Data was captured electronically on vaccine delivery levels across 1201 pharmacies....περισσότερα »
Elderly patients with polypharmacy
Clinical medication reviews in elderly patients with polypharmacy: a cross-sectional study on drug-related problems in the Netherlands: Abstract*Background* Knowledge of drug-related problems (DRPs) identified in the medication of home-dwelling elderly patients with polypharmacy has been based predominantly on medication reviews conducted in research settings rather than in daily practice. *Objective* To evaluate the prevalence of DRPs identified by means of a clinical medication review (CMR) and the implementation rate of proposed interventions in a large group of older patients w...περισσότερα »
Adverse drug reactions identification and reporting in a Pediatric Emergency Department
A comprehensive intervention for adverse drug reactions identification and reporting in a Pediatric Emergency Department: Abstract*Background* Physicians identify from 45.7 to 96.2 % of Adverse Drug Reactions (ADRs) in their patients, with under-reporting ranging from 6 to 100 %. In order to improve ADR reporting, several interventions have been evaluated in different studies, but not with regard to ADR identification. In addition, it is not known whether some patient characteristics might influence on ADR identification and reporting by physicians. *Objectives* (a) To assess the e... περισσότερα »
Colloidal silica-induced hypersensitivity
Colloidal silica-induced hypersensitivity: myth or reality: Abstract*Background* Many excipients have been reported to induce drug hypersensitivity (e.g. colouring additives, preservatives). Colloidal silica has never been reported to induce drug hypersensitivity reactions. *Case report* We report herein a 40-year-old patient who developed a skin eruption 2 days after Voltarene® (diclofenac) intake, confirmed by a positive patch test. Investigation of cross reactivity, assessed by patch testing to other non steroidal anti-inflammatory drugs, have showed a positive reaction only to ... περισσότερα »
Antibiotic dosing recommendations for sustained low-efficiency dialysis
Survey of pharmacists’ antibiotic dosing recommendations for sustained low-efficiency dialysis: Abstract*Background* The use of hybrid renal replacement therapies like sustained low efficiency dialysis (SLED) is increasing in ICUs worldwide. However, pharmacokinetic studies designed to inform therapeutic antibiotic dosing in critically ill patients receiving SLED are limited. SLED operational characteristics vary across institutions. Pharmacists in institutions that utilize SLED are challenged to recommend therapeutic doses for antibiotics. *Objective* To characterize pharmacist-re... περισσότερα »
When Many is not Too Many
Appropriate Polypharmacy and Medicine Safety: When Many is not Too Many: AbstractThe use of multiple medicines (polypharmacy) is increasingly common in middle-aged and older populations. Ensuring the correct balance between the prescribing of ‘many’ drugs and ‘too many’ drugs is a significant challenge. Clinicians are tasked with ensuring that patients receive the most appropriate combinations of medications based on the best available evidence, and that medication use is optimised according to patients’ clinical needs (appropriate polypharmacy). Historically, polypharmacy has been...περισσότερα »
Drug Interactions that Prolong the QT Interval
An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval: Abstract IntroductionDrug-induced prolongation of the QT interval on the electrocardiogram (long QT syndrome, LQTS) can lead to a potentially fatal ventricular arrhythmia known as* torsades de pointes* (TdP). Over 40 drugs with both cardiac and non-cardiac indications are associated with increased risk of TdP, but drug–drug interactions contributing to LQTS (QT-DDIs) remain poorly characterized. Traditional methods for mining observational healthcare data are poorly equipped to d...περισσότερα »
Evidence of Misclassification of Drug–Event Associations Classified as Gold Standard ‘Negative Controls’ by the Observational Medical Outcomes Partnership (OMOP)
Evidence of Misclassification of Drug–Event Associations Classified as Gold Standard ‘Negative Controls’ by the Observational Medical Outcomes Partnership (OMOP): Abstract IntroductionPharmacovigilance includes analysis of large databases of information on drugs and events using algorithms that detect disproportional frequencies of associations. In order to test such algorithms, attempts have been made to provide canonical reference lists of so-called ‘positive controls’ and ‘negative controls’. Reference sets with even modest levels of misclassification may result in under- or o... περισσότερα »
Prochlorperazine is recommended for adults with breakthrough or refractory chemotherapy-induced nausea and vomiting (CINV)
The Safety of Prochlorperazine in Children: A Systematic Review and Meta-Analysis: Abstract IntroductionProchlorperazine is recommended for adults with breakthrough or refractory chemotherapy-induced nausea and vomiting (CINV). The objective of this review was to describe its safety in children when given for any indication to help define its role for CINV control in children. MethodsElectronic searches of MEDLINE, EMBASE, PsycINFO, and the Cochrane Central Register of Controlled Trials were performed as of 9 March 2015. All studies in English reporting adverse effects (AEs) as... περισσότερα »
Rotavirus Vaccination
Post-Marketing Benefit–Risk Assessment of Rotavirus Vaccination in Japan: A Simulation and Modelling Analysis: Abstract IntroductionRotarix™, GSK’s live attenuated rotavirus vaccine, was introduced in Japan in 2011. A recent trend in reduction of rotavirus gastroenteritis (RVGE) due to this vaccine was described. However, an observed/expected analysis showed a temporal association with intussusception within 7 days post dose 1. ObjectiveIn this paper, we compare the benefit and risk of vaccination side-by-side in a benefit–risk analysis. MethodsThe number of vaccine-prevent... περισσότερα »
Hepatotoxicity Associated with the Use of Anti-TNF-α Agents
Hepatotoxicity Associated with the Use of Anti-TNF-α Agents: AbstractMedications to inhibit the actions of tumour necrosis factor alpha have revolutionized the treatment of several pro-inflammatory autoimmune conditions. Despite their many benefits, several serious side effects exist and adverse reactions do occur from these medications. While many of the medications’ potential adverse effects were anticipated and recognized in clinical trials prior to drug approval, several more rare adverse reactions were recorded in the literature as the popularity, availability and distribution... περισσότερα »
Clinicians’ Reports in Electronic Health Records Versus Patients’ Concerns in Social Media: A Pilot Study of Adverse Drug Reactions of Aspirin and Atorvastatin
Clinicians’ Reports in Electronic Health Records Versus Patients’ Concerns in Social Media: A Pilot Study of Adverse Drug Reactions of Aspirin and Atorvastatin: Abstract IntroductionLarge databases of clinician reported (e.g., allergy repositories) and patient reported (e.g., social media) adverse drug reactions (ADRs) exist; however, whether patients and clinicians report the same concerns is not clear. ObjectivesOur objective was to compare electronic health record data and social media data to better understand differences and similarities between clinician-reported ADRs an... περισσότερα »
Use of Prescription Drug Samples
Use of Prescription Drug Samples in the USA: A Descriptive Study with Considerations for Pharmacoepidemiology: Abstract IntroductionFree prescription drug samples provided in physician offices can lead to exposure misclassification in pharmacoepidemiologic studies that rely on pharmacy claims data. MethodsWe quantified drug-specific sample provision rates based on nationally projected data from a survey of over 3200 US office-based physicians for 1993–2013. ResultsBetween 2009 and 2013, a total of 44.7 % of newly initiated brand-only sitagliptin but only 3.6 % of genericall...περισσότερα »
Toxicovigilance: Automatic Monitoring of Prescription Medication Abuse
Social Media Mining for Toxicovigilance: Automatic Monitoring of Prescription Medication Abuse from Twitter: Abstract IntroductionPrescription medication overdose is the fastest growing drug-related problem in the USA. The growing nature of this problem necessitates the implementation of improved monitoring strategies for investigating the prevalence and patterns of abuse of specific medications. ObjectivesOur primary aims were to assess the possibility of utilizing social media as a resource for automatic monitoring of prescription medication abuse and to devise an automatic c... περισσότερα »
The Pharmacokinetics of Potassium in Humans is Unusual
The Pharmacokinetics of Potassium in Humans is Unusual: Abstract Potassium is critical for maintaining cellular tonicity, propagation of nerve impulses, contraction of cardiac, skeletal and smooth muscles and normal renal function. The focus of the review is on the pharmacokinetics of potassium, K+, after administration of liquid and solid formulations of potassium chloride, KCl, to healthy subjects. Potassium can be considered an endogenous and exogenous compound. The amounts of endogenous K+ are kept constant by balancing intake and loss of exogenous K+. Food and ingestion of KCl...περισσότερα »
Safety Concerns Surrounding Quinolone Use in Children
Safety Concerns Surrounding Quinolone Use in Children: Abstract Fluoroquinolones are highly effective antibiotics with many desirable pharmacokinetic and pharmacodynamic properties including high bioavailability, large volume of distribution, and a broad spectrum of antimicrobial activity. Despite the attractive profile as anti-infective agents, their use in children is limited, primarily due to safety concerns. In this review, we highlight the pharmacological properties of fluoroquinolones and describe their current use in pediatrics. In addition, we provide a comprehensive assess... περισσότερα »
Cabozantinib is a tyrosine kinase inhibitor approved for the treatment of patients with progressive, metastatic medullary thyroid cancer
Effect of Renal and Hepatic Impairment on the Pharmacokinetics of Cabozantinib: [image: cover.gif?v=1&s=7d6711fd3b3a3dbb6f549ca7] ABSTRACT Cabozantinib is a tyrosine kinase inhibitor approved for the treatment of patients with progressive, metastatic medullary thyroid cancer. Two clinical pharmacology studies were conducted to characterize single dose pharmacokinetics (PK) of cabozantinib in renal- or hepatic-impaired subjects. Study 1 enrolled 10 subjects each with mild or moderate impairment of renal function; 12 healthy subjects were matched to the moderate group for age, se... περισσότερα »
Identification of novel S-nitrosation sites in soluble guanylyl cyclase, the nitric oxide receptor
Publication date: Available online 18 February 2016 *Source:*Journal of Proteomics Author(s): Annie Beuve, Changgong Wu, Chuanlong Cui, Tong Liu, Mohit Raja Jain, Can Huang, Lin Yan, Vladyslav Kholodovych, Hong Li Soluble Guanylyl Cyclase (sGC) is the main receptor for nitric oxide (NO). NO activates sGC to synthesize cGMP, triggering a plethora of signals. Recently, we discovered that NO covalently modifies select sGC cysteines via a post-translational modification termed S-nitrosation or S-nitrosylation. Earlier characterization was conducted on a purified sGC treated with S-nitro...περισσότερα »
Carcinosarcoma of the upper urinary tract with an aggressive angiosarcoma component.
*Carcinosarcoma of the upper urinary tract with an aggressive angiosarcoma component.* Cancer Biol Ther. 2016 Feb 18;:0 Authors: Urteaga JL, Pous AF, Tapia G, Areal J, Taron M Abstract Carcinosarcomas (CS) are biphasic tumors with malignant epithelial and mesenchymal elements. The sarcomatoid elements of CS can include chondrosarcoma, malignant fibrous histiocytoma, osteosarcoma, leiomyosarcoma, fibrosarcoma, or liposarcoma. CS of the upper urinary tract are extremely rare but are associated with a poor prognosis. We report a case of a 44-year-old man with a localized right renal... περισσότερα »
Rapid induction of apoptosis in chronic lymphocytic leukemia cells by the microtubule disrupting agent BNC105.
*Rapid induction of apoptosis in chronic lymphocytic leukemia cells by the microtubule disrupting agent BNC105.* Cancer Biol Ther. 2016 Jan 30;:1-9 Authors: Bates D, Feris EJ, Danilov AV, Eastman A Abstract Microtubule targeting agents, such as vinblastine, are usually thought to arrest cells in mitosis and subsequently induce apoptosis. However, they can also cause rapid induction of apoptosis in a cell-cycle phase independent manner. BNC105 is a novel vascular and microtubule disrupting drug that also induces apoptosis rapidly but with markedly increased potency compared to vin... περισσότερα »
Propofol-Induced Loss of Consciousness
Race-Specific Pharmacodynamic Model of Propofol-Induced Loss of Consciousness: [image: cover.gif?v=1&s=7d6711fd3b3a3dbb6f549ca7] Abstract We present a race-specific model of propofol-induced loss of consciousness that is based on pharmacodynamic data collected and adapted from the peer-reviewed literature. In the proposed race-specific model that includes EC05 and EC95 concentrations, the median (EC50) (and where available 95% CI) propofol concentrations at the effect site compartment for propofol-induced loss of consciousness for Caucasians, Chinese, Blacks, and Indians are 2.... περισσότερα »
Inhalation of ambroxol inhibits cigarette smoke-induced acute lung injury
in a mouse model by inhibiting the Erk pathway via ScienceDirect Publication: International Immunopharmacology Publication date: April 2016 *Source:*International Immunopharmacology, Volume 33 Author(s): Ling-tian Ge, Ya-nan Liu, Xi-xi Lin, Hui-juan Shen, Yong-liang Jia, Xin-wei Dong, Yun Sun, Qiang-min Xie Oral and injection administration of ambroxol has been clinically used to treat airway disease. However, little is known about its potentials in inhalation therapy. In present studies, we tested the effects of ambroxol by inhalation with intravenous administration, and explored the ... περισσότερα »
The Effect of a High-Fat Meal on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor, in Patients with Advanced Solid Tumors or Lymphoma
The Effect of a High-Fat Meal on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor, in Patients with Advanced Solid Tumors or Lymphoma: [image: cover.gif?v=1&s=7d6711fd3b3a3dbb6f549ca7] Abstract Ixazomib is the first oral proteasome inhibitor to be investigated in the clinic. This clinical study assessed whether the pharmacokinetics of ixazomib would be altered if administered after a high-calorie, high-fat meal. Using a two-period, two-sequence, cross-over study design, adult patients with advanced solid tumors or lymphoma received a 4 mg oral dose of ixazomib as i...περισσότερα »
Novel delivery of Chlorin e6 using anti-EGFR antibody tagged virosomes for fluorescence diagnosis of oral cancer
in a hamster cheek pouch model via ScienceDirect Publication: European Journal of Pharmaceutical Sciences Publication date: 15 February 2016 *Source:*European Journal of Pharmaceutical Sciences, Volume 83 Author(s): Kar Perng Low, Ramaswamy Bhuvaneswari, Patricia S. Thong, Ralph M. Bunte, Khee Chee Soo PurposeOverexpression of epidermal growth factor receptor (EGFR) is observed in oral squamous cell carcinoma (OSCC) and is associated with increased proliferation, metastasis and therapeutic resistance. We aim to develop a novel drug delivery system comprised of a photosensitizer Chlorin... περισσότερα »
Polymeric micelles for anti-cancer drug delivery
Recent advances in via ScienceDirect Publication: European Journal of Pharmaceutical Sciences Publication date: 15 February 2016 *Source:*European Journal of Pharmaceutical Sciences, Volume 83 Author(s): Swati Biswas, Preeti Kumari, Prit Manish Lakhani, Balaram Ghosh Block co-polymeric micelles receive increased attention due to their ability to load therapeutics, deliver the cargo to the site of action, improve the pharmacokinetic of the loaded drug and reduce off-target cytotoxicity. While polymeric micelles can be developed with improved drug loading capabilities by modulating hydro... περισσότερα »
Dose and risk of hemorrhage among warfarin users
Race-specific influence of CYP4F2 on dose and risk of hemorrhage among warfarin users: Summary Objective The p.V433M in cytochrome P450 4F2 (rs2108622, *CYP4F2*3*) is associated with higher warfarin dose and lower risk of hemorrhage among European Americans. Herein, we evaluate the influence of *CYP4F2*3* on warfarin dose, time to target INR and stable dose, proportion of time spent in target range (PTTR), as well as the risk of overanticoagulation and hemorrhage among European and African Americans. Design *CYP4F2*3* was genotyped in 1238 patients initiated on warfarin in a prospe... περισσότερα »
Lenvatinib was recently approved for the treatment of radioiodine-refractory differentiated thyroid cancer (RR-DTC)
Population Pharmacokinetic Analysis of Lenvatinib in Healthy Subjects and Patients with Cancer: Aims Lenvatinib was recently approved for the treatment of radioiodine-refractory differentiated thyroid cancer (RR-DTC). Here we characterized the pharmacokinetic (PK) profile of lenvatinib and identified intrinsic and extrinsic factors that explain interindividual PK variability in humans. Methods This population PK analysis used pooled data from 15 clinical studies including 8 phase 1 studies in healthy subjects, 4 phase 1 studies in patients with solid tumours, 2 phase 2 studies in p... περισσότερα »
Co-administered azithromycin and piperaquine in pregnant women
Safety, tolerability and pharmacokinetic properties of co-administered azithromycin and piperaquine in pregnant Papua New Guinean women: [image: cover.gif?v=1&s=6cc8e1b4d994f104b1a5b1e0] Aims To investigate the safety, tolerability and pharmacokinetics of co-administered azithromycin (AZI) and piperaquine (PQ) in pregnant Papua New Guinean women. Methods Thirty women (median age 22 years; 16-32 weeks gestation) were given three daily doses of 1 g AZI plus 960 mg PQ tetraphosphate with detailed monitoring/blood sampling over 42 days. Plasma AZI and PQ were assayed using liquid ch... περισσότερα »
Investigation of novel solid lipid microparticles based on homolipids from Bos indicus for the delivery of gentamicin
Investigation of novel solid lipid microparticles based on homolipids from Bos indicus for the delivery of gentamicin: *Franklin C Kenechukwu, Mumuni A Momoh, Emmanuel C Umeyor, Emmanuel M Uronnachi, Anthony A Attama* International Journal of Pharmaceutical Investigation 2016 6(1):32-38 Background: The aim of this study was to formulate solidified reverse micellar solution (SRMS)-based solid lipid microparticles (SLMs) using homolipids from tallow fat (Bos indicus) and evaluate its potential for enhanced delivery of gentamicin. Materials and Methods: SLMs were formulated by melt...περισσότερα »
Balance training with and without an oscillating vibratory pole
Equilibrium in women with osteoporosis submitted to via ScienceDirect Publication: Journal of Bodywork and Movement Therapies Publication date: January 2016 *Source:*Journal of Bodywork and Movement Therapies, Volume 20, Issue 1 Author(s): Juliana Rodrigues Soares Ruzene, Mary Hellen Morcelli, Marcelo Tavella Navega ObjectivesAn eight-week balance training program, with and without oscillation of vibratory pole, was shown to have a medium-term persistence effect on the performance of elderly physically-active women with osteoporosis.MethodsThe 29 women who completed the study were rand... περισσότερα »
Training for improved neuro-muscular control of balance
in middle aged females via ScienceDirect Publication: Journal of Bodywork and Movement Therapies Publication date: January 2016 *Source:*Journal of Bodywork and Movement Therapies, Volume 20, Issue 1 Author(s): Gregory S. Anderson, Fabio Deluigi, Guido Belli, Claudio Tentoni, Michael B. Gaetz This study examined improvements in static balance and muscle electromyographic (EMG) activity following a four week progressive training program in 16 middle aged females (mean age = 46.9 ± 8.7 yrs; height 161.1 ± 6.0 cm; weight 65.4 ± 11.2 kg). Participants trained 3 times per week for 4 weeks,... περισσότερα »
Mixed light touch manual therapies on active duty soldiers with chronic post-traumatic stress disorder and injury to the head
Pilot study of the effects of via ScienceDirect Publication: Journal of Bodywork and Movement Therapies Publication date: January 2016 *Source:*Journal of Bodywork and Movement Therapies, Volume 20, Issue 1 Author(s): Lauren Davis, Brenda Hanson, Sara Gilliam This pilot study was designed to examine the effects of mixed Light Touch Manual Therapies (LTMT) on headache, anxiety and other symptoms suffered by active duty United States service members experiencing chronic Post-Traumatic Stress Disorder (PTSD). Ten service members diagnosed with PTSD and having a self-reported injury to the... περισσότερα »
Regulation of cancer-related genes – Cyp1a1, Cyp1b1, Cyp19, Nqo1 and Comt – expression in β-naphthoflavone-treated mice by miroestrol
Regulation of cancer-related genes – Cyp1a1, Cyp1b1, Cyp19, Nqo1 and Comt – expression in β-naphthoflavone-treated mice by miroestrol: Abstract Objective The effects of miroestrol (MR), an active phytoestrogen from *Pueraria candollei* var. *mirifica*, on expression of cancer-related genes were determined. Methods Seven-week-old female ICR mice (*n* = 5 each) were subcutaneously administered estradiol (E2, 0.5 mg/kg/day) or MR (0.5 or 5 mg/kg/day) daily for 7 days. Some were given ER or MR in combination with β-naphthoflavone (BNF, 30 mg/kg/day) for the last 3 days. The expression o...περισσότερα »
Chemosensitization of doxorubicin in multidrug-resistant cells by unimolecular micelles via increased cellular accumulation and apoptosis
Chemosensitization of doxorubicin in multidrug-resistant cells by unimolecular micelles via increased cellular accumulation and apoptosis: Abstract Objectives Unimolecular micelles were prepared by modification of polyamidoamine (PAMAM) dendrimers using Pluronic F127 (PF127), which is expected to reverse multidrug resistance (MDR). And the reversal mechanisms have been studied. Methods Characterization of the products was carried on. MTT assay was used to evaluate the cytotoxicity of the DOX-loaded conjugates. Cellular uptake study was measured by confocal laser scanning microscope ... περισσότερα »
Proton beam radiation therapy for adjuvant and definitive treatment of thymoma and thymic carcinoma: Early response and toxicity assessment
Prospective study of proton beam radiation therapy for adjuvant and definitive treatment of thymoma and thymic carcinoma: Early response and toxicity assessment: [image: gr1.sml] Radiation is an important modality in treatment of thymic tumors. However, toxicity may reduce its overall benefit. We hypothesized that double-scattering proton beam therapy (DS-PT) can achieve excellent local control with limited toxicity in patients with thymic malignancies.
Endoscopic Photography as a New and Objective Diagnostic Method for Chronic Tonsillitis
RGB Measurements From via Clinical Therapeutics Publication date: Available online 16 February 2016 *Source:*Clinical Therapeutics Author(s): Alper Yenigun, Remzi Dogan, Orhan Ozturan, Aysenur Meric Hafiz PurposeThis study assessed the diagnostic role of a digital photographic assessment of chronic tonsillitis. This study was performed at a tertiary referral center.MethodsThree cohorts of children were studied based on their diagnoses: current chronic tonsillitis (before tonsillectomy), previous chronic tonsillitis (3 months after tonsillectomy), and healthy children (control group). ...περισσότερα »
RGMa in modulation of bone marrow-derived dendritic cells maturation induced by lipopolysaccharide
A novel role for via ScienceDirect Publication: International Immunopharmacology Publication date: April 2016 *Source:*International Immunopharmacology, Volume 33 Author(s): Xuxu Xu, Yan Gao, Fengping Shan, Juan Feng Repulsive guidance molecule a (RGMa) is known to mediate immune responses and has been indicated to modulates T cell activation and autoimmune diseases by dendritic cells (DCs), which hints its significant function in the latter cells. The aim of our study, therefore, was to evaluate the function of RGMa in DC maturation. We found that small interfering RNA (siRNA) succes... περισσότερα »
Breath-to-breath reflex modulation of genioglossus muscle activity in obstructive sleep apnea
[image: S13899457.gif] Publication date: Available online 18 February 2016 *Source:*Sleep Medicine Author(s): Rodrigo T Martins, Jayne C Carberry, Danny J Eckert from #SleepMedicine via ola Kala on Inoreader http://ift.tt/1oP1Og4 via IFTTT
Beyond mean pharyngeal constrictor dose for beam path toxicity in non-target swallowing muscles
: Dose–volume correlates of chronic radiation-associated dysphagia (RAD) after oropharyngeal intensity modulated radiotherapy via Radiotherapy and Oncology Publication date: Available online 17 February 2016 *Source:*Radiotherapy and Oncology Author(s): MD Anderson Head and Neck Cancer Symptom Working GroupContributing authors:TimothyDaleKatherineHutchesonAbdallah S.R.MohamedJan S.LewinG. BrandonGunnArvind U.K.RaoJayashreeKalpathy-CramerSteven J.FrankAdam S.GardenJay A.MesserBenjaminWarrenStephen Y.LaiBeth M.BeadleWilliam H.MorrisonJackPhanHeathSkinnerNeilGrossRenataFerrarottoRandal S... περισσότερα »
Hospital re-admission associated with adverse drug reactions in patients over the age of 65 years
Hospital re-admission associated with adverse drug reactions in patients over the age of 65 years: Abstract ContextAdverse drug reactions (ADRs) are responsible for 5 % of hospital admissions, but hospital re-admission induced by ADRs remains poorly documented. ObjectiveThe aim of this study was to estimate the rate of hospital re-admission and the factors associated with re-admission in the patients over the age of 65 years. Secondary, we described the characteristics of cases of ADRs leading to re-admission for drugs other than chemotherapy agents. MethodsData were extra... περισσότερα »
Beyond mean pharyngeal constrictor dose for beam path toxicity in non-target swallowing muscles: Dose–volume correlates of chronic radiation-associated dysphagia (RAD) after oropharyngeal intensity modulated radiotherapy
Beyond mean pharyngeal constrictor dose for beam path toxicity in non-target swallowing muscles: Dose–volume correlates of chronic radiation-associated dysphagia (RAD) after oropharyngeal intensity modulated radiotherapy: [image: gr1.sml] We sought to identify swallowing muscle dose–response thresholds associated with chronic radiation-associated dysphagia (RAD) after IMRT for oropharyngeal cancer.
Anti-angiogenic therapy (bevacizumab) in the management of oral lichen planus
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Oral lichen planus (OLP), a mucocutaneous chronic inflammatory disease, is conventionally managed using topical corticosteroid therapy. Given the fact that OLP is strongly linked to angiogenesis, anti-angiogenic drugs, such as bevacizumab, might be introduced as an alternative treatment for contraindicated, non-responsive patients. The aim of the present study was to report the short-term effectiveness and […]
Breath-to-breath reflex modulation of genioglossus muscle activity in obstructive sleep apnea
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Publication date: Available online 18 February 2016 Source:Sleep Medicine Author(s): Rodrigo T Martins, Jayne C Carberry, Danny J Eckert from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1oP1Og4 via IFTTT
Three cases of pigmented cosmetic dermatitis-like eruptions associated with primary Sjögren’s syndrome or anti-SSA antibody
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Abstract Pigmented cosmetic dermatitis-like (Riehl’s melanosis-like) pigmentation was reported in three of 27 patients with primary Sjögren’s syndrome. But case reports of such eruptions are rare. We describe three cases of such eruptions associated with primary Sjögren’s syndrome or anti-SSA antibody and possible associations with specific types of human leukocyte antigen (HLA) and infiltrating lymphocytes. […]
Drug-induced hypersensitivity syndrome by ethambutol: A case report
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1osqjz2 via IFTTT
Detection and identification of Trichophyton tonsurans from clinical isolates and hairbrush samples by loop-mediated isothermal amplification system
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Abstract Since the 1990s, there have been reports of the spread of dermatophytosis caused by Trichophyton tonsurans among contact sports athletes in several countries, including Japan. This study was performed to develop a loop-mediated isothermal amplification (LAMP) system for rapid and accurate detection and identification of T. tonsurans from clinical isolates or hairbrush samples for […]
Inhibitory effect of a histamine 4 receptor antagonist on CCL17 and CCL22 production by monocyte-derived Langerhans cells in patients with atopic dermatitis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Abstract We examined the inhibitory effect of a histamine 4 receptor (H4R) antagonist (JNJ7777120) on CCL17 and CCL22 chemokine production by human monocyte-derived Langerhans cells (MoLC) in patients with atopic dermatitis (AD) and healthy controls (HC). We confirmed the significantly higher production of both CCL17 and CCL22 in the MoLC of AD patients compared with […]
Generalized granuloma annulare successfully treated with narrowband ultraviolet B and anti-hepatitis C virus therapy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Q5cL7k via IFTTT
Dermoscopy of Grover’s disease: Variability according to histological subtype
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
Abstract Distinguishing Grover’s disease from other papular dermatoses is often a troublesome task. According to two relatively recent case reports, dermoscopy may be useful in assisting the diagnosis of such a disorder by showing a peculiar pattern. The aim of this study was to evaluate the dermoscopic features of Grover’s disease in a larger series […]
Reticulate acropigmentation of Kitamura with a novel ADAM10 mutation: A case report
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1osqjiI via IFTTT
Toxic epidermal necrolysis with isolated neutropenia related to the use of levetiracetam
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 26 δευτερόλεπτα
from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Q5cMs4 via IFTTT
Neuronavigated left temporal continuous theta burst stimulation in chronic tinnitus.
*Neuronavigated left temporal continuous theta burst stimulation in chronic tinnitus.* Restor Neurol Neurosci. 2016 Jan 30; Authors: Schecklmann M, Giani A, Tupak S, Langguth B, Raab V, Polak T, Várallyay C, Harnisch W, Herrmann MJ, Fallgatter AJ Abstract PURPOSE: Clinical effects of repetitive transcranial magnetic stimulation (rTMS) in chronic tinnitus are moderate. More precise coil localisation strategies, innovative stimulation protocols, and identification of predictors for treatment response were proposed as promising attempts to enhance treatment efficacy. In this pilot s... περισσότερα »
[Middle ear adenoma: clinical and pathologic analysis].
*[Middle ear adenoma: clinical and pathologic analysis].* Zhonghua Bing Li Xue Za Zhi. 2015 Dec;44(12):900-4 Authors: Bai Y, Yue C, Yang D, Han Y, Zhang Y, Liu H Abstract OBJECTIVE: To investigate the clinical and pathologic features of middle ear adenoma (MEA). METHODS: Eight cases of MEA were collected from Beijing Tongren Hospital, Capital Medical University between 2004 and 2014, and immunohistochemical staining was performed. RESULTS: The patients included five women and three men (mean age, 37.5 years; median 37 years; range, 21-51 years). All patients had unilateral lesions...περισσότερα »
[Clinical features of sudden sensorineural hearing loss accompanied with inner ear hemorrhage].
*[Clinical features of sudden sensorineural hearing loss accompanied with inner ear hemorrhage].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;50(12):996-1000 Authors: Chen X, Lin C, Fang Z, Chen X, Ye S, Cheng J, Zhang R Abstract OBJECTIVE: To investigate the clinical features, diagnosis and prognosis of sudden sensorineural hearing loss accompanied with inner ear hemorrhage. METHODS: Eleven cases of sudden sensorineural hearing loss accompanied with inner ear hemorrhage were retrospectively analyzed, including clinical manifestation, hematological and audiological exam...περισσότερα »
[Cinical and genetic characteristics of familial Meniere's disease: three families report].
*[Cinical and genetic characteristics of familial Meniere's disease: three families report].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Nov;50(11):915-24 Authors: Gao Y, Wang D, Wang H, Guan J, Lan L, Wu Z, Xie L, Yu L, Zhang S, Shan X, Wang Q Abstract OBJECTIVE: To investigate the clinical and genetic characteristics of three Chinese Meniere's disease(MD) families and decipher the mechanism of MD further. METHODS: Personal and family medical evidence of hearing loss, vestibular symptoms, and other clinical abnormalities of the participants were identified, clinical and...περισσότερα »
A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies.
*A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies.* Phytother Res. 2016 Feb 17; Authors: Izzo AA, Hoon-Kim S, Radhakrishnan R, Williamson EM Abstract Systematic reviews and meta-analyses represent the uppermost ladders in the hierarchy of evidence. Systematic reviews/meta-analyses suggest preliminary or satisfactory clinical evidence for agnus castus (Vitex agnus castus) for premenstrual complaints, flaxseed (Linum usitatissimum) for hypertension, feverfew (Tanacetum partenium) for migraine prevention, ginger (Zingiber o...περισσότερα »
Streptolysin S Promotes Programmed Cell Death and Enhances Inflammatory Signaling in Epithelial Keratinocytes during Group A Streptococcus Infection.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Streptolysin S Promotes Programmed Cell Death and Enhances Inflammatory Signaling in Epithelial Keratinocytes during Group A Streptococcus Infection.* Infect Immun. 2015 Oct;83(10):4118-33 Authors: Flaherty RA, Puricelli JM, Higashi DL, Park CJ, Lee SW Abstract Streptococcus pyogenes, or group A Streptococcus (GAS), is a pathogen that causes a multitude of human diseases from pharyngitis to severe infections such as toxic shock syndrome and necrotizing fasciitis. One of the primary virulence factors produced by G...περισσότερα »
Diagnostic value of vestibular-evoked myogenic potentials in Ménière's disease and vestibular migraine.
*Diagnostic value of vestibular-evoked myogenic potentials in Ménière's disease and vestibular migraine.* J Vestib Res. 2016 Jan 28;25(5-6):261-266 Authors: Salviz M, Yuce T, Acar H, Taylan I, Yuceant GA, Karatas A Abstract Overlaps can be seen between vestibular migraine (VM) Ménière's Disease (MD) and diagnosis is difficult if hearing is normal. We aimed to investigate the sacculo-collic pathway in VM patients, MD patients, and healthy controls to define the diagnostic role of cervical VEMP (cVEMP). VEMP testing in response to 500 Hz and 1000 Hz air-conducted tone burst (TB) st... περισσότερα »
Falls and fear of falling in vertigo and balance disorders: A controlled cross-sectional study.
*Falls and fear of falling in vertigo and balance disorders: A controlled cross-sectional study.* J Vestib Res. 2016 Jan 28;25(5-6):241-251 Authors: Schlick C, Schniepp R, Loidl V, Wuehr M, Hesselbarth K, Jahn K Abstract BACKGROUND: Vertigo and dizziness are among the most prevalent symptoms in neurologic disorders. Although many of these patients suffer from postural instability and gait disturbances, there is only limited data on their risk of falling. METHODS: We conducted a controlled cross-sectional study at the tertiary care outpatient clinic of the German Center for Vertigo...περισσότερα »
Retrospective data suggests that the higher prevalence of benign paroxysmal positional vertigo in individuals with type 2 diabetes is mediated by hypertension.
*Retrospective data suggests that the higher prevalence of benign paroxysmal positional vertigo in individuals with type 2 diabetes is mediated by hypertension.* J Vestib Res. 2016 Jan 28;25(5-6):233-239 Authors: D'Silva LJ, Staecker H, Lin J, Sykes KJ, Phadnis MA, McMahon TM, Connolly D, Sabus CH, Whitney SL, Kluding PM Abstract OBJECTIVE: Benign Paroxysmal Positional Vertigo (BPPV) has been linked to comorbidities like diabetes and hypertension. However, the relationship between type 2 diabetes (DM) and BPPV is unclear. The purpose of this retrospective study was to examine the... περισσότερα »
[Clinical features of sudden sensorineural hearing loss accompanied with inner ear hemorrhage].
*[Clinical features of sudden sensorineural hearing loss accompanied with inner ear hemorrhage].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;50(12):996-1000 Authors: Chen X, Lin C, Fang Z, Chen X, Ye S, Cheng J, Zhang R Abstract OBJECTIVE: To investigate the clinical features, diagnosis and prognosis of sudden sensorineural hearing loss accompanied with inner ear hemorrhage. METHODS: Eleven cases of sudden sensorineural hearing loss accompanied with inner ear hemorrhage were retrospectively analyzed, including clinical manifestation, hematological and audiological exam...περισσότερα »
How many Epley manoeuvres are required to treat benign paroxysmal positional vertigo?
Related Articles *How many Epley manoeuvres are required to treat benign paroxysmal positional vertigo?* J Laryngol Otol. 2015 May;129(5):421-4 Authors: Hughes D, Shakir A, Goggins S, Snow D Abstract OBJECTIVE: To evaluate the total number of Epley manoeuvres required to provide symptomatic relief to patients newly diagnosed with benign paroxysmal positional vertigo. METHODS: This retrospective audit assessed every patient referred to the audiology department for investigations of their symptoms over a period of one year. Only patients diagnosed with benign paroxysmal positional v...περισσότερα »
Pattern of failure in patients treated for glottic squamous cell carcinoma with curative intent – A population based study from the DAHANCA group
Pattern of failure in 5001 patients treated for glottic squamous cell carcinoma with curative intent – A population based study from the DAHANCA group: [image: gr1.sml] To describe the pattern of failure in a national consecutive cohort of patients with glottic squamous cell carcinomas (SCC) treated with primary radiotherapy (RT) with curative intent over a 41-year period.
Emerging Role of Olanzapine for Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting
Emerging Role of Olanzapine for Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting: [image: cover.gif?v=1&s=40faf98dcbd9f62ccc5a442c] The prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) continues to pose a challenge for clinicians. The development of 5-hydroxytryptamine (serotonin) antagonists and neurokinin-1 receptor antagonists (NK1-RAs) have demonstrated significant improvements in acute and delayed CINV for highly and moderately emetogenic chemotherapy. Delayed and breakthrough CINV, however, continue to be difficult to manage d... περισσότερα »
Endothelial progenitor cells in angiogenic-mediated tumour metastasis
Significance and therapeutic implications of via anti-angiogenic drug Publication date: Available online 18 February 2016 *Source:*Critical Reviews in Oncology/Hematology Author(s): Valentina Flamini, Wen G. Jiang, Jane Lane, Yu-Xin Cui Cancer conveys profound social and economic consequences throughout the world. Metastasis is responsible for approximately 90% of cancer-associated mortality and, when it occurs, cancer becomes almost incurable. During metastatic dissemination, cancer cells pass through a series of complex steps including the establishment of tumour-associated angiogene... περισσότερα »
Non-melanoma skin cancer of the head and neck: the aid of reflectance confocal microscopy for the accurate diagnosis and management.
*Non-melanoma skin cancer of the head and neck: the aid of reflectance confocal microscopy for the accurate diagnosis and management.* G Ital Dermatol Venereol. 2016 Feb 18; Authors: Ferrari B, Salgarelli AC, Mandel VD, Bellini P, Reggiani C, Farnetani F, Pellacani G, Magnoni C Abstract BACKGOUND: Non-melanoma skin cancer (NMSC) represents the most common cutaneous neoplasms of the head and neck. In recent years, novel non-invasive diagnostic tool have been developed, and among these we have the reflectance confocal microscopy (RCM), that offers the evaluation of the skin at real... περισσότερα »
Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma.
[image: http:--images.hindawi.com-linkout-hindaw] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma.* Biomed Res Int. 2015;2015:432479 Authors: Curioni-Fontecedro A, Pitocco R, Schoenewolf NL, Holzmann D, Soldini D, Dummer R, Calvieri S, Moch H, Mihic-Probst D, Fitsche A Abstract Mucosal melanoma is a rare disease, which differs from its cutaneous counterpart genetically and for its clinical behaviour. Moreover this is a heterogeneous disease based on the tissue of origin. As CT7 and C... περισσότερα »
Cancer Risk and Eicosanoid Production: Interaction between the Protective Effect of Long Chain Omega-3 Polyunsaturated Fatty Acid Intake and Genotype.
*Cancer Risk and Eicosanoid Production: Interaction between the Protective Effect of Long Chain Omega-3 Polyunsaturated Fatty Acid Intake and Genotype.* J Clin Med. 2016;5(2) Authors: Lenihan-Geels G, Bishop KS, Ferguson LR Abstract Dietary inclusion of fish and fish supplements as a means to improve cancer prognosis and prevent tumour growth is largely controversial. Long chain omega-3 polyunsaturated fatty acids (LCn-3 PUFA), eicosapentaenoic acid and docosahexaenoic acid, may modulate the production of inflammatory eicosanoids, thereby influencing local inflammatory status, wh...περισσότερα »
[Vitamin D--A New Vector of Cancer Prevention?].
Related Articles *[Vitamin D--A New Vector of Cancer Prevention?].* Vestn Ross Akad Med Nauk. 2015;(5):526-33 Authors: Kobyakova OS, Deev IA, Tyufilin DS, Kulikov ES Abstract Currently, a great number of research projects are focused on finding new treatment methods for cancer and carcinogenesis predictors, as well as the ways to dicrease cancer development risks. This article provides an overview of research on vitamin D as cancer prevention factor. The results of independent experiments and in vitro tests explaining the mechanisms of protective effect of vitamin D and its deriv...περισσότερα »
Development and evaluation of targeting ligand-anchored CNTs as prospective targeted drug delivery system.
*Development and evaluation of targeting ligand-anchored CNTs as prospective targeted drug delivery system.* Artif Cells Nanomed Biotechnol. 2016 Feb 18;:1-9 Authors: Kaur S, Mehra NK, Jain K, Jain NK Abstract Our main investigation in the present research was to developt and evaluate targeting ligand-anchored multiwalled carbon nanotubes (MWCNTs) as prospective targeted drug delivery system, with a special focus on the MWCNTs surface functionalization (FA-PEG bis-amine functionalized, carboxylated MWCNTs). In vitro release of 5-fluorouracil (5-FU) was studied at pH 7.4 phosphate...περισσότερα »
Fatty acid vesicles acting as expanding horizon for transdermal delivery.
*Fatty acid vesicles acting as expanding horizon for transdermal delivery.* Artif Cells Nanomed Biotechnol. 2016 Feb 18;:1-10 Authors: Kumar L, Verma S, Kumar S, Prasad DN, Jain AK Abstract The body is protected against the external environment by the skin due to its physical barrier nature. Stratum corneum composed of corneocytes surrounded by lipid region performs a major barrier function as it lies in the uppermost area of skin. Alteration in barrier function, increase in permeability, and disorganization of stratum corneum represent diseased skin. Drugs applied to the diseased...περισσότερα »
Progressive Generalized Lipodystrophy as a Manifestation of Autoimmune Polyglandular Syndrome Type 1.
*Progressive Generalized Lipodystrophy as a Manifestation of Autoimmune Polyglandular Syndrome Type 1.* J Clin Endocrinol Metab. 2016 Feb 18;:jc20153722 Authors: Sorkina E, Frolova E, Rusinova D, Polyakova S, Roslavtseva E, Vasilyev E, Petrov V, Tiulpakov A Abstract CONTEXT: The classic clinical triad of autoimmune polyglandular syndrome type 1 (APS1) is composed of Addison disease, hypoparathyroidism, and chronic mucocutaneous candidiasis, however other endocrine and non-endocrine features of APS1 may occur. Here we report on a challenging diagnosis of APS 1 in a patient who was... περισσότερα »
Iodine supplementation of mildly iodine deficient adults lowers thyroglobulin: a randomized controlled trial.
*Iodine supplementation of mildly iodine deficient adults lowers thyroglobulin: a randomized controlled trial.* J Clin Endocrinol Metab. 2016 Feb 18;:jc20153591 Authors: Feei Ma Z, Venn BJ, Manning PJ, Cameron CM, Skeaff SA Abstract CONTEXT: An inverse relationship between thyroglobulin (Tg) and urinary iodine concentration (UIC) has been found in children potentially making Tg a viable blood marker of iodine status. The application of Tg in adults is unknown. OBJECTIVE: To determine the efficacy of Tg to assess iodine status in adults. DESIGN: A randomized, double-blind, placebo-... περισσότερα »
Nephrotoxicity as a Dose-Limiting Factor in a High-Dose Cisplatin-Based Chemoradiotherapy Regimen for Head and Neck Carcinomas.
*Nephrotoxicity as a Dose-Limiting Factor in a High-Dose Cisplatin-Based Chemoradiotherapy Regimen for Head and Neck Carcinomas.* Cancers (Basel). 2016;8(2) Authors: Hoek J, Bloemendal KM, van der Velden LA, van Diessen JN, van Werkhoven E, Klop WM, Tesselaar ME Abstract Purpose: Loco-regional control and organ preservation are significantly improved with concomitant cisplatin/radiotherapy and are compromised with less than 5% grade 3 nephrotoxicity (creatinine clearance 15-29 mL/min). However, although clinically important, in none of the randomized trials is grade 2 nephrotoxic...περισσότερα »
Variations of mucosal-sparing septectomy for endonasal approach to the craniocervical junction.
*Variations of mucosal-sparing septectomy for endonasal approach to the craniocervical junction.* Laryngoscope. 2016 Feb 18; Authors: Eloy JA, Vazquez A, Marchiano E, Baredes S, Liu JK Abstract OBJECTIVES/HYPOTHESIS: Recent advances in surgical techniques have rendered the craniocervical junction (CCJ) accessible transnasally. Endoscopic endonasal transclival and transodontoid approaches are routinely performed in leading skull base centers. Usually, these approaches involve a posterior bony and mucosal septectomy, which may compromise the vascularized pedicled nasoseptal flap (P... περισσότερα »
Narrow band imaging for the diagnosis of head and neck squamous cell carcinoma: A systematic review.
*Narrow band imaging for the diagnosis of head and neck squamous cell carcinoma: A systematic review.* Head Neck. 2016 Feb 18; Authors: Cosway B, Drinnan M, Paleri V Abstract Narrow band imaging (NBI) is reported to improve the diagnostic accuracy of head and neck cancers. The purpose of this review was to evaluate the diagnostic accuracy of NBI in the literature. A systematic review was performed in PubMed, Web of Knowledge, and the Cochrane Library until March 2015. Two reviewers independently assessed articles and extracted data. Meta-analyses were performed in MetaDisc 1.6. F... περισσότερα »
Risk of swallowing-related chest infections in patients with nasopharyngeal carcinoma treated with definitive intensity-modulated radiotherapy.
*Risk of swallowing-related chest infections in patients with nasopharyngeal carcinoma treated with definitive intensity-modulated radiotherapy.* Head Neck. 2016 Feb 18; Authors: Xiong J, Krishnaswamy G, Raynor S, Loh KS, Kwa AL, Lim CM Abstract BACKGROUND: Pulmonary complications secondary to dysphagia may be encountered in patients with nasopharyngeal carcinoma (NPC) after definitive intensity-modulated radiotherapy. The purpose of this study was to identify patients with NPC at risk of developing swallowing-related chest infections (SRCIs). METHODS: Retrospective chart review ... περισσότερα »
Induction docetaxel and S-1 followed by concomitant radiotherapy with low-dose daily cisplatin in locally advanced head and neck carcinoma.
*Induction docetaxel and S-1 followed by concomitant radiotherapy with low-dose daily cisplatin in locally advanced head and neck carcinoma.* Head Neck. 2016 Feb 18; Authors: Kim HR, Lee CG, Choi EC, Kim JH, Koh YW, Cho BC Abstract BACKGROUND: The purpose of this study was to assess the efficacy and safety of induction chemotherapy with docetaxel-S-1, and radiotherapy (RT) with concurrent daily cisplatin in locally advanced head and neck carcinoma. METHOD: Fifty patients received 2 cycles of induction chemotherapy with induction chemotherapy with docetaxel and S-1, followed by 7 cy... περισσότερα »
Association between multidisciplinary team care approach and survival rates in patients with oral cavity squamous cell carcinoma.
*Association between multidisciplinary team care approach and survival rates in patients with oral cavity squamous cell carcinoma.* Head Neck. 2016 Feb 18; Authors: Liao CT, Kang CJ, Lee LY, Hsueh C, Lin CY, Fan KH, Wang HM, Ng SH, Lin CH, Tsao CK, Fang TJ, Huang SF, Chang KP, Chang YL, Yang LY, Yen TC Abstract BACKGROUND: The purpose of this study was to investigate whether multidisciplinary team care (MDTC) is associated with outcomes in oral cavity squamous cell carcinoma (SCC). METHODS: We retrospectively examined 1616 patients with oral cavity SCC who underwent radical surger... περισσότερα »
Rare cases of benign tumors of the head and neck: lipoma of larynx and sternocleidomastoid muscle.
*Rare cases of benign tumors of the head and neck: lipoma of larynx and sternocleidomastoid muscle.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):118-22 Authors: Demir D, Eraslan Ö, Güven M, Kösem M Abstract In this article, we report two rare cases of lipoma in the head and neck region. Thirty-four-year-old case 1 presented with hoarseness and sensation of foreign body in throat. While 54-year-old case 2 presented with complaint of a mass in left side of neck. The imaging methods showed the masses in false vocal fold and the sternocleidomastoid muscle. Diagnosis and treatmen...περισσότερα »
Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis.
*Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis.* Head Neck. 2016 Feb 18; Authors: Zhang WB, Peng X Abstract Cervical treatment of oral maxillary squamous cell carcinoma (SCC) remains controversial. We determined the metastases incidence and evaluated its predictive factors. Systematic review and meta-analysis was conducted of 23 Chinese and English-language articles retrieved from PubMed, Ovid, Embase, Cochrane Library, China National Knowledge Infrastructure, and Chinese Scientific and Technological Journal databases. Total ...περισσότερα »
Local 'free-style' perforator flaps in head and neck reconstruction: an update and a useful classification.
*Local 'free-style' perforator flaps in head and neck reconstruction: an update and a useful classification.* Plast Reconstr Surg. 2016 Feb 11; Authors: Kokkoli E, Shih HS, Spyropoulou GA, Jeng SF PMID: 26890505 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1PVWI8x via IFTTT
A Huge Ancient Schwannoma of the Epiglottis.
*A Huge Ancient Schwannoma of the Epiglottis.* J Craniofac Surg. 2016 Feb 15; Authors: Lee DH, Kim JH, Yoon TM, Lee JK, Lim SC Abstract Ancient schwannoma of the epiglottis is extremely rare. The authors report the first case of a patient with a huge ancient schwannoma of the epiglottis. Clinicians should consider the possibility that ancient schwannoma may originate in the epiglottis mimicking the other more frequently observed lesions. PMID: 26890461 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1SE2wZR via IFTTT
Retrospective data suggests that the higher prevalence of benign paroxysmal positional vertigo in individuals with type 2 diabetes is mediated by hypertension.
*Retrospective data suggests that the higher prevalence of benign paroxysmal positional vertigo in individuals with type 2 diabetes is mediated by hypertension.* J Vestib Res. 2016 Jan 28;25(5-6):233-239 Authors: D'Silva LJ, Staecker H, Lin J, Sykes KJ, Phadnis MA, McMahon TM, Connolly D, Sabus CH, Whitney SL, Kluding PM Abstract OBJECTIVE: Benign Paroxysmal Positional Vertigo (BPPV) has been linked to comorbidities like diabetes and hypertension. However, the relationship between type 2 diabetes (DM) and BPPV is unclear. The purpose of this retrospective study was to examine the... περισσότερα »
Future Oncology; +22 new citations
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *Future Oncology* These pubmed results were generated on 2016/02/19 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1LwQHx4 via IFTTT
Prevalence of Airflow Limitation Defined by Pre- and Post-Bronchodilator Spirometry in a Community-Based Health Checkup: The Hisayama Study.
*Prevalence of Airflow Limitation Defined by Pre- and Post-Bronchodilator Spirometry in a Community-Based Health Checkup: The Hisayama Study.* Tohoku J Exp Med. 2016;238(2):179-84 Authors: Fukuyama S, Matsumoto K, Kaneko Y, Kan-O K, Noda N, Tajiri-Asai Y, Nakano T, Ishii Y, Kiyohara Y, Nakanishi Y, Inoue H, Hisayama Pulmonary Physiology Study Group Abstract Spirometry in health checkup may contribute to early diagnosis of chronic obstructive pulmonary disease (COPD) and asthma. Although post-bronchodilator airflow limitation is essential for definite diagnosis of COPD and post-br... περισσότερα »
MUC1–MBP/BCG anti-tumor vaccine
Pre-clinical toxicity and immunogenicity evaluation of a via ScienceDirect Publication: International Immunopharmacology Publication date: April 2016 *Source:*International Immunopharmacology, Volume 33 Author(s): Boqi Hu, Juan Wang, Yingying Guo, Tanxiu Chen, Weihua Ni, Hongyan Yuan, Nannan Zhang, Fei Xie, Guixiang Tai Mucin 1 (MUC1), as an oncogene, plays a key role in the progression and tumorigenesis of many human adenocarcinomas and is an attractive target in tumor immunotherapy. Our previous study showed that the MUC1–MBP/BCG anti-tumor vaccine induced a MUC1-specific Th1-dominan... περισσότερα »
Very high-energy electron radiotherapy planning
Assessment of the quality of via Radiotherapy and Oncology Publication date: Available online 18 February 2016 *Source:*Radiotherapy and Oncology Author(s): Bianey Palma, Magdalena Bazalova-Carter, Björn Hårdemark, Elin Hynning, Bradley Qu, Billy W. Loo, Peter G. Maxim Background and purposeTo assess the quality of very-high energy electron (VHEE) scanning pencil beam radiation therapy in relation to state-of-the-art volumetric modulated arc therapy (VMAT) and to determine the extent of its application.Material and methodsWe planned five clinical cases with VHEE scanning pencil beams ... περισσότερα »
Management of Eosinophilic Esophagitis During Pregnancy
Management of Eosinophilic Esophagitis During Pregnancy: AbstractThere are currently limited data on the management of eosinophilic esophagitis (EoE) during pregnancy. At our center, however, we have followed several pregnant women with EoE and others have asked pertinent questions in pre-pregnancy counseling. The relatively young age of patients with EoE implies that many practitioners will also encounter patients with these questions. In this review, we use four cases to prompt a discussion about concerns focused on the safety of steroids and diet therapy during pregnancy and bre... περισσότερα »
Reticulate acropigmentation of Kitamura with a novel ADAM10 mutation: A case report
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1osqjiI via IFTTT
Toxic epidermal necrolysis with isolated neutropenia related to the use of levetiracetam
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Q5cMs4 via IFTTT
Stereological assessment of sexual dimorphism in the rat liver reveals differences in hepatocytes and Kupffer cells but not hepatic stellate cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
Abstract There is long-standing evidence that male and female rat livers differ in enzyme activity. More recently, differences in gene expression profiling have also been found to exist; however, it is still unclear whether there is morphological expression of male/female differences in the normal liver. Such differences could help to explain features seen at the […]
Musculoskeletal architecture of the prey capture apparatus in salamandrid newts with multiphasic lifestyle: does anatomy change during the seasonal habitat switches?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
Abstract Some newt species change seasonally between an aquatic and a terrestrial life as adults, and are therefore repeatedly faced with different physical circumstances that affect a wide range of functions of the organism. For example, it has been observed that seasonally habitat-changing newts display notable changes in skin texture and tail fin anatomy, allowing […]
Mini Review of the Cost-Effectiveness of Unilateral Osseointegrated Implants in Adults: Possibly Cost-Effective for the Correct Indication
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
An osseointegrated implant (e.g. bone-anchored hearing aid, BAHA) is a surgically implantable device for unilateral sensorineural and unilateral or bilateral conductive hearing loss in patients who otherwise cannot use or do not prefer a conventional air conduction hearing aid (ACHA). The specific indications for an osseointegrated implant are evolving and dependent upon the country or […]
Predictive value of repeated F-18 FDG PET/CT parameters changes during preoperative chemoradiotherapy to predict pathologic response and overall survival in locally advanced esophageal adenocarcinoma patients
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
Abstract Introduction The goal of the current study was to investigate the predictive and prognostic values of repeated F-18 FDG PET/CT parameter changes for prediction of complete pathologic response (pCR) in patients with adenocarcinoma of locally advanced esophageal cancer (LAEC) who received preoperative concurrent chemoradiotherapy (PCRT). Methods A total 53 patients with LAEC patients were […]
IJMS, Vol. 17, Pages 256: Recent Advances in Disease Modeling and Drug Discovery for Diabetes Mellitus Using Induced Pluripotent Stem Cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
Diabetes mellitus (DM) is a widespread metabolic disease with a progressive incidence of morbidity and mortality worldwide. Despite extensive research, treatment options for diabetic patients remains limited. Although significant challenges remain, induced pluripotent stem cells (iPSCs) have the capacity to differentiate into any cell type, including insulin-secreting pancreatic β cells, highlighting its potential as a […]
A simple and sensitive flow injection method based on catalytic activity of CdS quantum dots in acidic permanganate chemiluminescence system for determination of formaldehyde in water and wastewater
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
Photochem. Photobiol. Sci., 2016, Accepted Manuscript DOI: 10.1039/C5PP00452G, Paper Alireza Khataee, Roya Lotfi, Aliyeh Hasanzadeh, M Iranifam A simple and sensitive flow injection chemiluminescence (CL) method in which CdS quantum dots (QDs) enhanced the CL intensity of KMnO4-formaldehyde (HCHO) reaction was offered for determination of HCHO. This… The content of this RSS Feed (c) The […]
An Adjuvant-Free Mouse Model of Transdermal Sensitization and Oral Elicitation of Anaphylaxis to Shellfish
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
Background: Shellfish (SF) allergy is a leading cause of systemic anaphylaxis in humans. An adjuvant-free mouse model to evaluate allergenicity and oral anaphylaxis to SF is currently unavailable. Here, we tested the hypothesis that transdermal exposure (TDE) to SF protein extract (SFPE) not only elicits a systemic allergic immune response but also will clinically sensitize […]
The Impact of Mast Cell Density on the Progression of Bone Disease in Multiple Myeloma Patients
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
Background: Osteolytic bone disease is a major hallmark in multiple myeloma (MM) progression and affects many patients. Several inflammatory cells are involved in MM progression. Among them, mast cells (MCs) accumulated in the bone marrow (BM) microenvironment are known to play an important role in the mechanism of neovascularization. Methods: In 52 newly diagnosed active […]
Stereological assessment of sexual dimorphism in the rat liver reveals differences in hepatocytes and Kupffer cells but not hepatic stellate cells
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
Abstract There is long-standing evidence that male and female rat livers differ in enzyme activity. More recently, differences in gene expression profiling have also been found to exist; however, it is still unclear whether there is morphological expression of male/female differences in the normal liver. Such differences could help to explain features seen at the […]
Musical experience sharpens human cochlear tuning
Musical experience sharpens human cochlear tuning via Hearing Research Publication date: Available online 18 February 2016 *Source:*Hearing Research Author(s): Gavin M. Bidelman, Caitlin Nelms, Shaum P. Bhagat The mammalian cochlea functions as a filter bank that performs a spectral, Fourier-like decomposition on the acoustic signal. While tuning can be compromised (e.g., broadened with hearing impairment), whether or not human cochlear frequency resolution can be sharpened through experiential factors (e.g., training or learning) has not yet been established. Previous studies have de...περισσότερα »
"Physiological" Ear Clicking: Its Origin and Potential Usability as a Test Tool for the Eustachian Tube Function.
"Physiological" Ear Clicking: Its Origin and Potential Usability as a Test Tool for the Eustachian Tube Function.: Objective: To explore the origin of "physiological" ear clicks during deglutition or other pharyngeal movements, which, in contrast to disturbing frequent clicks under pathologic conditions, mostly remain unnoticed by the patient. Study Design: Clinical experimental study at a tertiary referral center. Methods: Ear clicks were recorded by a microphone sealing the external ear canal parallel to endoscopic or manometric evaluations of the Eustachian tube function. Result... περισσότερα »
Mandarin Tone Identification in Cochlear Implant Users Using Exaggerated Pitch Contours.
Mandarin Tone Identification in Cochlear Implant Users Using Exaggerated Pitch Contours.: Objective: To determine whether exaggerating the variations in fundamental frequency (F0) contours of Mandarin-based pitch fluctuations could improve tone identification by cochlear implant (CI) users. Methods: Twelve normal-hearing (NH) listeners and 11 CI users were tested for their ability to recognize F0 contours modeled after Mandarin tones, in 4- or 5-alternatives forced-choice paradigms. Two types of stimuli were used: computer-generated complex tones and voice recordings. Four contours ... περισσότερα »
Auditory neuropathy spectrum disorder with Brown-Vialetto-Van Laere syndrome: challenges in hearing rehabilitation.
Auditory neuropathy spectrum disorder with Brown-Vialetto-Van Laere syndrome: challenges in hearing rehabilitation.: Authors: Chandran R, Alexander M, Naina P, Balraj A Abstract BACKGROUND: Brown-Vialetto-Van Laere syndrome is a rare neurological disorder characterised by pontobulbar palsy and sensorineural hearing loss. Hearing rehabilitation continues to be a challenge because the exact lesion site is unknown. CASE REPORT: We examined the clinical and audiological profiles of a case series comprising four siblings with Brown-Vialetto-Van Laere syndrome who had decreased hearing ... περισσότερα »
Comparison of Consanguinity between Parents of Hearing Impaired and Public School Children with Estimation of Risk.
Comparison of Consanguinity between Parents of Hearing Impaired and Public School Children with Estimation of Risk Authors: Sattar MA, Sultana MT Abstract Deafness is the hidden disability and the most common human sensory defects which lead to poor educational and employment prospects of childhood. Is there any association of consanguinity and hearing loss or are there any difference of association of consanguinity and hearing loss in specialized and public school children and how much risk is associated?--were the research questions of this study. Total 428 participants have been...περισσότερα »
Familial Meniere's disease
[Cinical and genetic characteristics of familial Meniere's disease: three families report] Authors: Gao Y, Wang D, Wang H, Guan J, Lan L, Wu Z, Xie L, Yu L, Zhang S, Shan X, Wang Q Abstract OBJECTIVE: To investigate the clinical and genetic characteristics of three Chinese Meniere's disease(MD) families and decipher the mechanism of MD further. METHODS: Personal and family medical evidence of hearing loss, vestibular symptoms, and other clinical abnormalities of the participants were identified, clinical and genetic features were analyzed. Targeted 307 genes capture and high-thro...περισσότερα »
Mini Review of the Cost-Effectiveness of Unilateral Osseointegrated Implants in Adults: Possibly Cost-Effective for the Correct Indication
Mini Review of the Cost-Effectiveness of Unilateral Osseointegrated Implants in Adults: Possibly Cost-Effective for the Correct Indication: An osseointegrated implant (e.g. bone-anchored hearing aid, BAHA) is a surgically implantable device for unilateral sensorineural and unilateral or bilateral conductive hearing loss in patients who otherwise cannot use or do not prefer a conventional air conduction hearing aid (ACHA). The specific indications for an osseointegrated implant are evolving and dependent upon the country or regulatory body overseeing the provision of these devices. H... περισσότερα »
Anti-angiogenic therapy (bevacizumab) in the management of oral lichen planus
Oral lichen planus (OLP), a mucocutaneous chronic inflammatory disease, is conventionally managed using topical corticosteroid therapy. Given the fact that OLP is strongly linked to angiogenesis, anti-angiogenic drugs, such as bevacizumab, might be introduced as an alternative treatment for contraindicated, non-responsive patients. The aim of the present study was to report the short-term effectiveness and… Continue reading Anti-angiogenic therapy (bevacizumab) in the management of oral lichen planus
A comparative histopathological study of vocal fold polyps in smokers versus non-smokers.
Related Articles A comparative histopathological study of vocal fold polyps in smokers versus non-smokers. J Laryngol Otol. 2015 May;129(5):484-8 Authors: Effat KG, Milad M Abstract BACKGROUND: A large proportion of patients with vocal fold polyps are cigarette smokers. However, prior to this report no comparative study of polyp histopathology in smokers versus non-smokers had been… Continue reading A comparative histopathological study of vocal fold polyps in smokers versus non-smokers.
Variations of mucosal‐sparing septectomy for endonasal approach to the craniocervical junction
ConclusionThese variations/refinements of the mucosal‐sparing approach to the CCJ allowed adequate surgical access with sufficient maneuverability while preserving both PNSFs. Level of EvidenceNA. Laryngoscope, 2015 (Source: The Laryngoscope) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too. from #Head and Neck by Sfakianakis via simeraentaxei on… Continue reading Variations of mucosal‐sparing septectomy for endonasal approach to the craniocervical junction
Update on current evaluation and management of pediatric nasal dermoid
ConclusionPreoperative imaging of nasal dermoid is crucial to evaluate for intracranial extension, thus facilitating complete removal. Thin section, high‐resolution magnetic resonance with contrast provides excellent detail of the extent of the nasal dermoid including intracranial extension. Thin‐section high‐resolution computed tomography with multiplanar reformatted images provides complimentary information regarding the bone anatomy of the frontonasal region.… Continue reading Update on current evaluation and management of pediatric nasal dermoid
Rapidly Growing Lateral Neck Mass
A man in his 50s has a rapidly enlarging neck mass and recent weight loss; flexible laryngoscopy reveals reduced movement of the vocal cord, laryngeal deviation, and asymmetry and CT reveals a well-vascularized mass. What is your diagnosis? (Source: JAMA Otolaryngology – Head and Neck Surgery) MedWorm Sponsor Message: Directory of the best January Sales… Continue reading Rapidly Growing Lateral Neck Mass
Fiberoptic intubation or video tube for trauma patient intubation—which method to choose? Randomized crosso ver manikin trial
We read with interest the article of Bilge et al [1] concerning on endotracheal intubation (ETI) with tactical fiberoptic imaging systems. Under the conditions of cervical spine suspected damage and to limit the movements of the spine, direct laryngoscopy using laryngoscope with Macintosh or Miller blade may be difficult [1–3]. In such cases, we should… Continue reading Fiberoptic intubation or video tube for trauma patient intubation—which method to choose? Randomized crosso ver manikin trial
Hyperocclusion stimulates the expression of collagen type XII in periodontal ligament
Publication date: Available online 18 February 2016 Source:Archives of Oral Biology Author(s): Takashi Tsuzuki, Hiroshi Kajiya, Kazuko T-Goto, Takashi Tsutsumi, Tetsuomi Nemoto, Koji Okabe, Yutaka Takahashi ObjectivesIt is known that excessive mechanical force exerted by hyperocclusion induces occlusal trauma. However, the mechanism of the process remains unclear. In the present study, we employed an in… Continue reading Hyperocclusion stimulates the expression of collagen type XII in periodontal ligament
Tympanic paraganglioma—Resection techniques
Tympanic paragangliomas (TP) arise in the middle ear along the course of Jacobson׳s or Arnold׳s nerve. These lesions can vary from small masses on the cochlear promontory to tumors that extend into the mastoid and external auditory canal. Surgical excision is the treatment of choice for TP with very low-recurrence rates. The various surgical approaches… Continue reading Tympanic paraganglioma—Resection techniques
Allergic rhinitis affects the duration of rapid eye movement sleep in children with sleep-disordered breathing without sleep apnea
Background Our goals were to assess whether allergic rhinitis (AR) is an aggravating factor that affects the severity of sleep apnea in children with tonsils/adenoid hypertrophy (T&A) and to compare polysomnographic data from children with and without AR. Methods This prospective study included 135 children (age range, 3 to 14 years) with sleep-disordered breathing (SDB)… Continue reading Allergic rhinitis affects the duration of rapid eye movement sleep in children with sleep-disordered breathing without sleep apnea
Sphenoid sinus malignancies: a population-based comprehensive analysis
Background Sinonasal malignancies are rare, representing less than 1% of all cancers, with the sphenoid sinus accounting for 1% to 2% of these cases. Sphenoid sinus malignancies exhibit very poor outcomes. There is a paucity of literature describing their histopathological features, incidence trends, treatment, and survival. We seek to elucidate these factors using a national… Continue reading Sphenoid sinus malignancies: a population-based comprehensive analysis
Mini Review of the Cost-Effectiveness of Unilateral Osseointegrated Implants in Adults: Possibly Cost-Effective for the Correct Indication
An osseointegrated implant (e.g. bone-anchored hearing aid, BAHA) is a surgically implantable device for unilateral sensorineural and unilateral or bilateral conductive hearing loss in patients who otherwise cannot use or do not prefer a conventional air conduction hearing aid (ACHA). The specific indications for an osseointegrated implant are evolving and dependent upon the country or regulatory body overseeing the provision of these devices. However, there are general groups of patients who would be likely to benefit, one such group being patients with congenital aural atresia. ... περισσότερα »
Outcomes in adult survivors of childhood burn injuries as compared with matched controls
Journal of Burn Care & Research from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RTdLNe via IFTTT
Ketamine as rescue treatment for difficult-to-sedate severe acute behavioral disturbance in the emergency department
Annals of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RTdLwG via IFTTT
Overdose deaths from common sedatives have surged, new study finds
Montefiore Medical Center News from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PKl4En via IFTTT
Patients with burns versus patients with complex skin and soft-tissue disease: an analysis of outcomes in the United States
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Lymphocytic choriomeningitis virus infection induced by percutaneous exposure
Occupational Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PKl47f via IFTTT
Nanoemulsion therapy for burn wounds is effective as a topical antimicrobial against gram-negative and gram-positive bacteria
Journal of Burn Care & Research from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PKl474 via IFTTT
Alkalis and Skin
Journal of Burn Care & Research from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PKl3Qw via IFTTT
The use of CO2 fractional photothermolysis for the treatment of burn scars
Journal of Burn Care & Research from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PKl5rJ via IFTTT
Post traumatic intra thoracic spleen presenting with upper GI bleed! – a case report
BMC Gastroenterology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PKl337 via IFTTT
Therapy induces widespread reorganization of motor cortex after complete spinal transection that supports motor recovery
Experimental Neurology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PKl2fw via IFTTT
Clot-busting drug reduces death risk in hemorrhagic stroke patients
Johns Hopkins Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PKkZAt via IFTTT
Using fixed anatomical landmarks to avoid medial rectus injury: A radiographic analysis in patients with and without Graves’ disease
American Journal of Otolaryngology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PKl1Iy via IFTTT
Comparison of high- and low-dose dexamethasone for preventing postextubation airway obstruction in adults: a prospective, randomized, double blind, placebo-controlled study
International Journal of Gerontology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PKkZjO via IFTTT
Traumatic brain injury and obesity induce persistent central insulin resistance
European Journal of Neuroscience from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PKl1rV via IFTTT
Neutrophil accumulation in the small intestine contributes to local tissue destruction following combined radiation and burn injury
Journal of Burn Care & Research from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PKkYMI via IFTTT
Complications associated with operative fixation of acute midshaft clavicle fractures
Injury from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PKkYwn via IFTTT
Hasbro Children's Hospital study finds nearly half of all teens visiting emergency department report peer violence and cyberbullying, many showing signs of PTSD
Lifespan from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PKkYfI via IFTTT
Stereological assessment of sexual dimorphism in the rat liver reveals differences in hepatocytes and Kupffer cells but not hepatic stellate cells
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
Abstract There is long-standing evidence that male and female rat livers differ in enzyme activity. More recently, differences in gene expression profiling have also been found to exist; however, it is still unclear whether there is morphological expression of male/female differences in the normal liver. Such differences could help to explain features seen at the pathological level, such as the greater regenerative potential generally attributed to the female liver. In this paper, hepatocytes (HEP), Kupffer cells (KC) and hepatic stellate cells (HSC) of male and female rats were ex... περισσότερα »
Musculoskeletal architecture of the prey capture apparatus in salamandrid newts with multiphasic lifestyle: does anatomy change during the seasonal habitat switches?
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
Abstract Some newt species change seasonally between an aquatic and a terrestrial life as adults, and are therefore repeatedly faced with different physical circumstances that affect a wide range of functions of the organism. For example, it has been observed that seasonally habitat-changing newts display notable changes in skin texture and tail fin anatomy, allowing one to distinguish an aquatic and a terrestrial morphotype. One of the main functional challenges is the switch between efficient aquatic and terrestrial prey capture modes. Recent studies have shown that newts adapt ... περισσότερα »
[Clinical study of the influence of laryngopharyngeal reflux on quality of life in patients with dysphonia].
*[Clinical study of the influence of laryngopharyngeal reflux on quality of life in patients with dysphonia].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;50(12):973-7 Authors: Wang Y, Zhang L, Yu L, Li J, Li J, Zhao Y, Cao J Abstract OBJECTIVE: To explore the morbidity of laryngopharyngeal reflux in patients with dysphonic diseases and to investigate the influence of LPR on the patients. METHODS: One hundred and twenty-seven patients with dysphonic diseases were encountered in Peking University of the People Hospital. Under the agreement, the patients were asked to fi... περισσότερα »
Future Oncology; +22 new citations
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *Future Oncology* These pubmed results were generated on 2016/02/19 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1LwQHx4 via IFTTT
Errata.
*Errata.* Radiat Res. 2016 Feb;185(2):e52 Authors: PMID: 26890301 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1XBxdyl via IFTTT
James William Osborne, PhD 1928-2015.
*James William Osborne, PhD 1928-2015.* Radiat Res. 2016 Feb;185(2):214-216 Authors: Spitz DR, Hauer-Jensen M PMID: 26890300 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1owV3Q5 via IFTTT
[Neurobrucellosis: a treatable cause of sensorineural hearing loss not to ignore].
*[Neurobrucellosis: a treatable cause of sensorineural hearing loss not to ignore].* Pan Afr Med J. 2015;22:122 Authors: Malhi AB, Ridal M, Bouchal S, Belahsen MF, El Alami MN PMID: 26889303 [PubMed - in process] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1Qox5Tg via IFTTT
Prevalence of Airflow Limitation Defined by Pre- and Post-Bronchodilator Spirometry in a Community-Based Health Checkup: The Hisayama Study.
*Prevalence of Airflow Limitation Defined by Pre- and Post-Bronchodilator Spirometry in a Community-Based Health Checkup: The Hisayama Study.* Tohoku J Exp Med. 2016;238(2):179-84 Authors: Fukuyama S, Matsumoto K, Kaneko Y, Kan-O K, Noda N, Tajiri-Asai Y, Nakano T, Ishii Y, Kiyohara Y, Nakanishi Y, Inoue H, Hisayama Pulmonary Physiology Study Group Abstract Spirometry in health checkup may contribute to early diagnosis of chronic obstructive pulmonary disease (COPD) and asthma. Although post-bronchodilator airflow limitation is essential for definite diagnosis of COPD and post-br... περισσότερα »
Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders.
*Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders.* Tohoku J Exp Med. 2016;238(2):165-77 Authors: Liu D, Zhao X, Zeng X, Dan H, Chen Q Abstract Oral squamous cell carcinoma (OSCC) is the most common oral and maxillofacial malignancy, and its morbidity and mortality rates are still high in most countries. Oral potentially malignant disorders (PMDs) are used to refer to a heterogeneous group of conditions that are characterized by increased risk for malignant transformation to OSCC. Currently identified oral PMDs include leukoplakia, eryth...περισσότερα »
Falls and fear of falling in vertigo and balance disorders: A controlled cross-sectional study.
*Falls and fear of falling in vertigo and balance disorders: A controlled cross-sectional study.* J Vestib Res. 2016 Jan 28;25(5-6):241-251 Authors: Schlick C, Schniepp R, Loidl V, Wuehr M, Hesselbarth K, Jahn K Abstract BACKGROUND: Vertigo and dizziness are among the most prevalent symptoms in neurologic disorders. Although many of these patients suffer from postural instability and gait disturbances, there is only limited data on their risk of falling. METHODS: We conducted a controlled cross-sectional study at the tertiary care outpatient clinic of the German Center for Vertigo...περισσότερα »
Retrospective data suggests that the higher prevalence of benign paroxysmal positional vertigo in individuals with type 2 diabetes is mediated by hypertension.
*Retrospective data suggests that the higher prevalence of benign paroxysmal positional vertigo in individuals with type 2 diabetes is mediated by hypertension.* J Vestib Res. 2016 Jan 28;25(5-6):233-239 Authors: D'Silva LJ, Staecker H, Lin J, Sykes KJ, Phadnis MA, McMahon TM, Connolly D, Sabus CH, Whitney SL, Kluding PM Abstract OBJECTIVE: Benign Paroxysmal Positional Vertigo (BPPV) has been linked to comorbidities like diabetes and hypertension. However, the relationship between type 2 diabetes (DM) and BPPV is unclear. The purpose of this retrospective study was to examine the... περισσότερα »
[Clinical features of sudden sensorineural hearing loss accompanied with inner ear hemorrhage].
*[Clinical features of sudden sensorineural hearing loss accompanied with inner ear hemorrhage].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;50(12):996-1000 Authors: Chen X, Lin C, Fang Z, Chen X, Ye S, Cheng J, Zhang R Abstract OBJECTIVE: To investigate the clinical features, diagnosis and prognosis of sudden sensorineural hearing loss accompanied with inner ear hemorrhage. METHODS: Eleven cases of sudden sensorineural hearing loss accompanied with inner ear hemorrhage were retrospectively analyzed, including clinical manifestation, hematological and audiological exam...περισσότερα »
How many Epley manoeuvres are required to treat benign paroxysmal positional vertigo?
Related Articles *How many Epley manoeuvres are required to treat benign paroxysmal positional vertigo?* J Laryngol Otol. 2015 May;129(5):421-4 Authors: Hughes D, Shakir A, Goggins S, Snow D Abstract OBJECTIVE: To evaluate the total number of Epley manoeuvres required to provide symptomatic relief to patients newly diagnosed with benign paroxysmal positional vertigo. METHODS: This retrospective audit assessed every patient referred to the audiology department for investigations of their symptoms over a period of one year. Only patients diagnosed with benign paroxysmal positional ...περισσότερα »
Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis.
*Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis.* Head Neck. 2016 Feb 18; Authors: Zhang WB, Peng X Abstract Cervical treatment of oral maxillary squamous cell carcinoma (SCC) remains controversial. We determined the metastases incidence and evaluated its predictive factors. Systematic review and meta-analysis was conducted of 23 Chinese and English-language articles retrieved from PubMed, Ovid, Embase, Cochrane Library, China National Knowledge Infrastructure, and Chinese Scientific and Technological Journal databases. Total ...περισσότερα »
CAN HALF VALUE LAYER MEASUREMENTS BE USED TOGETHER WITH THE EFFECTIVE ENERGY TO OBTAIN CONVERSION COEFFICIENTS FOR X-RAY SPECTRA?
*CAN HALF VALUE LAYER MEASUREMENTS BE USED TOGETHER WITH THE EFFECTIVE ENERGY TO OBTAIN CONVERSION COEFFICIENTS FOR X-RAY SPECTRA?* Radiat Prot Dosimetry. 2016 Feb 16; Authors: Behnke B, Hupe O Abstract Conversion coefficients are a substantial vehicle in practical radiation protection to determine the dose (rate) of a given radiation field. According to ICRU report 57, their values shall be obtained by means of spectrometry. This is, however, a time-consuming complicated procedure that cannot be performed by all dosimetry laboratories. Therefore, it is desired to find acceptable... περισσότερα »
Croup as Unusual Presentation of Post-transplantation Lymphoproliferative Disorder after Liver Transplantation in an 18-month-old Child.
*Croup as Unusual Presentation of Post-transplantation Lymphoproliferative Disorder after Liver Transplantation in an 18-month-old Child.* Int J Organ Transplant Med. 2016;7(1):57-60 Authors: Keshtkari A, Dehghani SM, Haghighat M, Imanieh MH, Nasimfard A, Yousefi G, Javaherizadeh H Abstract Post-transplantation lymphoproliferative disorder (PTLD) is a serious complication of solid organ transplantation that occurs due to immunosuppression and other risk factors. PTLD may present with involvement of other organs and with unusual presentation. The presentation is often extranodal (... περισσότερα »
[Clinical and Immunological Features of Infectious Complications in Patients with Multiple Myeloma].
Related Articles *[Clinical and Immunological Features of Infectious Complications in Patients with Multiple Myeloma].* Vestn Ross Akad Med Nauk. 2015;(5):534-40 Authors: Smirnova OV, Manchuk VT, Agilova YN Abstract BACKGROUND: Infectious complications--the leading cause of mortality in patients with multiple myeloma (MM), their appearance is regarded as an adverse prognostic factor in the course of the disease. OBJECTIVE: The aim of our study was to evaluate the clinical and immunological features of infectious complications in patients with G-immunochemical MM to find the most ... περισσότερα »
[Clinical study of the influence of laryngopharyngeal reflux on quality of life in patients with dysphonia].
*[Clinical study of the influence of laryngopharyngeal reflux on quality of life in patients with dysphonia].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;50(12):973-7 Authors: Wang Y, Zhang L, Yu L, Li J, Li J, Zhao Y, Cao J Abstract OBJECTIVE: To explore the morbidity of laryngopharyngeal reflux in patients with dysphonic diseases and to investigate the influence of LPR on the patients. METHODS: One hundred and twenty-seven patients with dysphonic diseases were encountered in Peking University of the People Hospital. Under the agreement, the patients were asked to fi... περισσότερα »
Future Oncology; +22 new citations
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *Future Oncology* These pubmed results were generated on 2016/02/19 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1LwQHx4 via IFTTT
Errata.
*Errata.* Radiat Res. 2016 Feb;185(2):e52 Authors: PMID: 26890301 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1XBxdyl via IFTTT
James William Osborne, PhD 1928-2015.
*James William Osborne, PhD 1928-2015.* Radiat Res. 2016 Feb;185(2):214-216 Authors: Spitz DR, Hauer-Jensen M PMID: 26890300 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1owV3Q5 via IFTTT
[Neurobrucellosis: a treatable cause of sensorineural hearing loss not to ignore].
*[Neurobrucellosis: a treatable cause of sensorineural hearing loss not to ignore].* Pan Afr Med J. 2015;22:122 Authors: Malhi AB, Ridal M, Bouchal S, Belahsen MF, El Alami MN PMID: 26889303 [PubMed - in process] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1Qox5Tg via IFTTT
Prevalence of Airflow Limitation Defined by Pre- and Post-Bronchodilator Spirometry in a Community-Based Health Checkup: The Hisayama Study.
*Prevalence of Airflow Limitation Defined by Pre- and Post-Bronchodilator Spirometry in a Community-Based Health Checkup: The Hisayama Study.* Tohoku J Exp Med. 2016;238(2):179-84 Authors: Fukuyama S, Matsumoto K, Kaneko Y, Kan-O K, Noda N, Tajiri-Asai Y, Nakano T, Ishii Y, Kiyohara Y, Nakanishi Y, Inoue H, Hisayama Pulmonary Physiology Study Group Abstract Spirometry in health checkup may contribute to early diagnosis of chronic obstructive pulmonary disease (COPD) and asthma. Although post-bronchodilator airflow limitation is essential for definite diagnosis of COPD and post-br... περισσότερα »
Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders.
*Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders.* Tohoku J Exp Med. 2016;238(2):165-77 Authors: Liu D, Zhao X, Zeng X, Dan H, Chen Q Abstract Oral squamous cell carcinoma (OSCC) is the most common oral and maxillofacial malignancy, and its morbidity and mortality rates are still high in most countries. Oral potentially malignant disorders (PMDs) are used to refer to a heterogeneous group of conditions that are characterized by increased risk for malignant transformation to OSCC. Currently identified oral PMDs include leukoplakia, eryth...περισσότερα »
Falls and fear of falling in vertigo and balance disorders: A controlled cross-sectional study.
*Falls and fear of falling in vertigo and balance disorders: A controlled cross-sectional study.* J Vestib Res. 2016 Jan 28;25(5-6):241-251 Authors: Schlick C, Schniepp R, Loidl V, Wuehr M, Hesselbarth K, Jahn K Abstract BACKGROUND: Vertigo and dizziness are among the most prevalent symptoms in neurologic disorders. Although many of these patients suffer from postural instability and gait disturbances, there is only limited data on their risk of falling. METHODS: We conducted a controlled cross-sectional study at the tertiary care outpatient clinic of the German Center for Vertigo...περισσότερα »
Retrospective data suggests that the higher prevalence of benign paroxysmal positional vertigo in individuals with type 2 diabetes is mediated by hypertension.
*Retrospective data suggests that the higher prevalence of benign paroxysmal positional vertigo in individuals with type 2 diabetes is mediated by hypertension.* J Vestib Res. 2016 Jan 28;25(5-6):233-239 Authors: D'Silva LJ, Staecker H, Lin J, Sykes KJ, Phadnis MA, McMahon TM, Connolly D, Sabus CH, Whitney SL, Kluding PM Abstract OBJECTIVE: Benign Paroxysmal Positional Vertigo (BPPV) has been linked to comorbidities like diabetes and hypertension. However, the relationship between type 2 diabetes (DM) and BPPV is unclear. The purpose of this retrospective study was to examine the... περισσότερα »
[Clinical features of sudden sensorineural hearing loss accompanied with inner ear hemorrhage].
*[Clinical features of sudden sensorineural hearing loss accompanied with inner ear hemorrhage].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Dec;50(12):996-1000 Authors: Chen X, Lin C, Fang Z, Chen X, Ye S, Cheng J, Zhang R Abstract OBJECTIVE: To investigate the clinical features, diagnosis and prognosis of sudden sensorineural hearing loss accompanied with inner ear hemorrhage. METHODS: Eleven cases of sudden sensorineural hearing loss accompanied with inner ear hemorrhage were retrospectively analyzed, including clinical manifestation, hematological and audiological exam...περισσότερα »
How many Epley manoeuvres are required to treat benign paroxysmal positional vertigo?
Related Articles *How many Epley manoeuvres are required to treat benign paroxysmal positional vertigo?* J Laryngol Otol. 2015 May;129(5):421-4 Authors: Hughes D, Shakir A, Goggins S, Snow D Abstract OBJECTIVE: To evaluate the total number of Epley manoeuvres required to provide symptomatic relief to patients newly diagnosed with benign paroxysmal positional vertigo. METHODS: This retrospective audit assessed every patient referred to the audiology department for investigations of their symptoms over a period of one year. Only patients diagnosed with benign paroxysmal positional ...περισσότερα »
Induction docetaxel and S-1 followed by concomitant radiotherapy with low-dose daily cisplatin in locally advanced head and neck carcinoma.
*Induction docetaxel and S-1 followed by concomitant radiotherapy with low-dose daily cisplatin in locally advanced head and neck carcinoma.* Head Neck. 2016 Feb 18; Authors: Kim HR, Lee CG, Choi EC, Kim JH, Koh YW, Cho BC Abstract BACKGROUND: The purpose of this study was to assess the efficacy and safety of induction chemotherapy with docetaxel-S-1, and radiotherapy (RT) with concurrent daily cisplatin in locally advanced head and neck carcinoma. METHOD: Fifty patients received 2 cycles of induction chemotherapy with induction chemotherapy with docetaxel and S-1, followed by 7 cy... περισσότερα »
Association between multidisciplinary team care approach and survival rates in patients with oral cavity squamous cell carcinoma.
*Association between multidisciplinary team care approach and survival rates in patients with oral cavity squamous cell carcinoma.* Head Neck. 2016 Feb 18; Authors: Liao CT, Kang CJ, Lee LY, Hsueh C, Lin CY, Fan KH, Wang HM, Ng SH, Lin CH, Tsao CK, Fang TJ, Huang SF, Chang KP, Chang YL, Yang LY, Yen TC Abstract BACKGROUND: The purpose of this study was to investigate whether multidisciplinary team care (MDTC) is associated with outcomes in oral cavity squamous cell carcinoma (SCC). METHODS: We retrospectively examined 1616 patients with oral cavity SCC who underwent radical surger... περισσότερα »
Diagnostic usefulness of FDG-PET/CT in advanced malignant lymphoma of the uterus: report of two cases.
Related Articles *Diagnostic usefulness of FDG-PET/CT in advanced malignant lymphoma of the uterus: report of two cases.* Eur J Gynaecol Oncol. 2015;36(6):737-41 Authors: Okuda T, Ijichil S, Yamashita S, Yoshioka T, Nishigaki H, Kitawaki J Abstract Summary Malignant lymphoma of the uterus is difficult to diagnose because of its rarity and nonspecific symptoms. However, recently, 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has become an important non-invasive diagnostic tool for the management of lymphoma patients. The authors report tw... περισσότερα »
[Significance of IKZF1 gene copy number abnormalities in BCR/ABL-negative B-lineage acute lymphoblastic leukemia in children].
Related Articles *[Significance of IKZF1 gene copy number abnormalities in BCR/ABL-negative B-lineage acute lymphoblastic leukemia in children].* Zhongguo Dang Dai Er Ke Za Zhi. 2015 Nov;17(11):1154-9 Authors: Zou Y, Liu XM, Zhang L, Chen YM, Guo Y, Chen XJ, Yang WY, Wang SC, Ruan M, Liu TF, Zhang JY, Liu F, Qi BQ, Zhu XF Abstract OBJECTIVE: To identify IKZF1 gene copy number abnormalities in BCR/ABL-negative B-lineage acute lymphoblastic leukemia (B-ALL) in children, and to investigate the association between such abnormalities and prognosis. METHODS: Multiplex ligation-dependen... περισσότερα »
Prediction of Central Nervous System Relapse of Diffuse Large B-Cell Lymphoma Using Pretherapeutic [18F]2-Fluoro-2-Deoxyglucose (FDG) Positron Emission Tomography/Computed Tomography.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Prediction of Central Nervous System Relapse of Diffuse Large B-Cell Lymphoma Using Pretherapeutic [18F]2-Fluoro-2-Deoxyglucose (FDG) Positron Emission Tomography/Computed Tomography.* Medicine (Baltimore). 2015 Nov;94(44):e1978 Authors: Song YS, Lee WW, Lee JS, Kim SE Abstract Central nervous system (CNS) relapse of diffuse large B-cell lymphoma (DLBCL) is a rare complication, but has a poor prognosis with unknown pathophysiology. Recent trials of CNS prophylaxis have shown to be ineffective, despite patient's s... περισσότερα »
Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis.
*Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis.* Head Neck. 2016 Feb 18; Authors: Zhang WB, Peng X Abstract Cervical treatment of oral maxillary squamous cell carcinoma (SCC) remains controversial. We determined the metastases incidence and evaluated its predictive factors. Systematic review and meta-analysis was conducted of 23 Chinese and English-language articles retrieved from PubMed, Ovid, Embase, Cochrane Library, China National Knowledge Infrastructure, and Chinese Scientific and Technological Journal databases. Total ...περισσότερα »
CAN HALF VALUE LAYER MEASUREMENTS BE USED TOGETHER WITH THE EFFECTIVE ENERGY TO OBTAIN CONVERSION COEFFICIENTS FOR X-RAY SPECTRA?
*CAN HALF VALUE LAYER MEASUREMENTS BE USED TOGETHER WITH THE EFFECTIVE ENERGY TO OBTAIN CONVERSION COEFFICIENTS FOR X-RAY SPECTRA?* Radiat Prot Dosimetry. 2016 Feb 16; Authors: Behnke B, Hupe O Abstract Conversion coefficients are a substantial vehicle in practical radiation protection to determine the dose (rate) of a given radiation field. According to ICRU report 57, their values shall be obtained by means of spectrometry. This is, however, a time-consuming complicated procedure that cannot be performed by all dosimetry laboratories. Therefore, it is desired to find acceptable... περισσότερα »
Croup as Unusual Presentation of Post-transplantation Lymphoproliferative Disorder after Liver Transplantation in an 18-month-old Child.
*Croup as Unusual Presentation of Post-transplantation Lymphoproliferative Disorder after Liver Transplantation in an 18-month-old Child.* Int J Organ Transplant Med. 2016;7(1):57-60 Authors: Keshtkari A, Dehghani SM, Haghighat M, Imanieh MH, Nasimfard A, Yousefi G, Javaherizadeh H Abstract Post-transplantation lymphoproliferative disorder (PTLD) is a serious complication of solid organ transplantation that occurs due to immunosuppression and other risk factors. PTLD may present with involvement of other organs and with unusual presentation. The presentation is often extranodal (... περισσότερα »
[Clinical and Immunological Features of Infectious Complications in Patients with Multiple Myeloma].
Related Articles *[Clinical and Immunological Features of Infectious Complications in Patients with Multiple Myeloma].* Vestn Ross Akad Med Nauk. 2015;(5):534-40 Authors: Smirnova OV, Manchuk VT, Agilova YN Abstract BACKGROUND: Infectious complications--the leading cause of mortality in patients with multiple myeloma (MM), their appearance is regarded as an adverse prognostic factor in the course of the disease. OBJECTIVE: The aim of our study was to evaluate the clinical and immunological features of infectious complications in patients with G-immunochemical MM to find the most ... περισσότερα »
Diagnostic usefulness of FDG-PET/CT in advanced malignant lymphoma of the uterus: report of two cases.
Related Articles *Diagnostic usefulness of FDG-PET/CT in advanced malignant lymphoma of the uterus: report of two cases.* Eur J Gynaecol Oncol. 2015;36(6):737-41 Authors: Okuda T, Ijichil S, Yamashita S, Yoshioka T, Nishigaki H, Kitawaki J Abstract Summary Malignant lymphoma of the uterus is difficult to diagnose because of its rarity and nonspecific symptoms. However, recently, 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has become an important non-invasive diagnostic tool for the management of lymphoma patients. The authors report tw... περισσότερα »
[Significance of IKZF1 gene copy number abnormalities in BCR/ABL-negative B-lineage acute lymphoblastic leukemia in children].
Related Articles *[Significance of IKZF1 gene copy number abnormalities in BCR/ABL-negative B-lineage acute lymphoblastic leukemia in children].* Zhongguo Dang Dai Er Ke Za Zhi. 2015 Nov;17(11):1154-9 Authors: Zou Y, Liu XM, Zhang L, Chen YM, Guo Y, Chen XJ, Yang WY, Wang SC, Ruan M, Liu TF, Zhang JY, Liu F, Qi BQ, Zhu XF Abstract OBJECTIVE: To identify IKZF1 gene copy number abnormalities in BCR/ABL-negative B-lineage acute lymphoblastic leukemia (B-ALL) in children, and to investigate the association between such abnormalities and prognosis. METHODS: Multiplex ligation-dependen... περισσότερα »
Prediction of Central Nervous System Relapse of Diffuse Large B-Cell Lymphoma Using Pretherapeutic [18F]2-Fluoro-2-Deoxyglucose (FDG) Positron Emission Tomography/Computed Tomography.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Prediction of Central Nervous System Relapse of Diffuse Large B-Cell Lymphoma Using Pretherapeutic [18F]2-Fluoro-2-Deoxyglucose (FDG) Positron Emission Tomography/Computed Tomography.* Medicine (Baltimore). 2015 Nov;94(44):e1978 Authors: Song YS, Lee WW, Lee JS, Kim SE Abstract Central nervous system (CNS) relapse of diffuse large B-cell lymphoma (DLBCL) is a rare complication, but has a poor prognosis with unknown pathophysiology. Recent trials of CNS prophylaxis have shown to be ineffective, despite patient's s... περισσότερα »
Long-Term use of Modified Dietsin Huntington's Disease: A Descriptive Clinical Practice Analysis on Improving Dietary Enjoyment.
*Long-Term use of Modified Dietsin Huntington's Disease: A Descriptive Clinical Practice Analysis on Improving Dietary Enjoyment.* J Huntingtons Dis. 2016 Feb 3; Authors: Moorhouse B, Fisher CA Abstract Dysphagia is a very common occurrence in Huntington's disease (HD). As such, many people with HD require texture modified diets. This commentary discusses the implications for individuals living long-term on modified diets, including the loss of sensory stimulation and dietary enjoyment. Clinical practice analyses of two interventions aimed at promoting dietary satisfaction and in...περισσότερα »
Objective prediction of pharyngeal swallow dysfunction in dysphagia through artificial neural network modeling.
*Objective prediction of pharyngeal swallow dysfunction in dysphagia through artificial neural network modeling.* Neurogastroenterol Motil. 2016 Mar;28(3):336-344 Authors: Kritas S, Dejaeger E, Tack J, Omari T, Rommel N Abstract BACKGROUND: Pharyngeal pressure-flow analysis (PFA) of high resolution impedance-manometry (HRIM) with calculation of the swallow risk index (SRI) can quantify swallow dysfunction predisposing to aspiration. We explored the potential use of artificial neural networks (ANN) to model the relationship between PFA swallow metrics and aspiration and to predict ...περισσότερα »
Swallowing in primary progressive aphasia.
*Swallowing in primary progressive aphasia.* NeuroRehabilitation. 2016 Feb 10;38(1):85-92 Authors: Marin SM, Bertolucci PH, Marin LF, de Oliveira FF, Wajman JR, Bahia VS, Mansur LL Abstract BACKGROUND: Few studies have described characteristics of swallowing in primary progressive aphasia (PPA) and its variants. OBJECTIVE: To describe and characterize swallowing and eating behaviors of patients with PPA, as well as their correlates with neuropsychiatric symptoms and patterns of communication. METHODS: We studied 16 patients with PPA and 16 their caregivers. PPA was subdivided in a... περισσότερα »
Physiology Of Drowning: A Review.
*Physiology Of Drowning: A Review.* Physiology (Bethesda). 2016 Mar;31(2):147-66 Authors: Bierens JJ, Lunetta P, Tipton M, Warner DS Abstract Drowning physiology relates to two different events: immersion (upper airway above water) and submersion (upper airway under water). Immersion involves integrated cardiorespiratory responses to skin and deep body temperature, including cold shock, physical incapacitation, and hypovolemia, as precursors of collapse and submersion. The physiology of submersion includes fear of drowning, diving response, autonomic conflict, upper airway reflex...περισσότερα »
Sensors, Vol. 16, Pages 247: Social Milieu Oriented Routing: A New Dimension to Enhance Network Security in WSNs
In large-scale wireless sensor networks (WSNs), in order to enhance network security, it is crucial for a trustor node to perform social milieu oriented routing to a target a trustee node to carry out trust evaluation. This challenging social milieu oriented routing with more than one end-to-end Quality of Trust (QoT) constraint has proved to be NP-complete. Heuristic algorithms with polynomial and pseudo-polynomial-time complexities are often used to deal with this challenging problem. However, existing solutions cannot guarantee the efficiency of searching; that is, they can har... περισσότερα »
Sensitive Zn2+ Sensor based on Biofunctionalized Nanopores by Combination of DNAzyme and DNA Supersandwich Structures
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C6AN00171H, Communication nannan liu, Ruizuo Hou, Pengcheng Gao, Xiaoding Lou, fan xia The sensitivity of the detection based on biofunctionalized nanopores is limited since the target-to-signal ratio is 1:1. Isothermal amplification is a promising amplified strategy at constant temperature due to its... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1LwI5Xb Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greec...περισσότερα »
IJMS, Vol. 17, Pages 250: Assessment of Radiation Induced Therapeutic Effect and Cytotoxicity in Cancer Patients Based on Transcriptomic Profiling
Toxicity induced by radiation therapy is a curse for cancer patients undergoing treatment. It is imperative to understand and define an ideal condition where the positive effects notably outweigh the negative. We used a microarray meta-analysis approach to measure global gene-expression before and after radiation exposure. Bioinformatic tools were used for pathways, network, gene ontology and toxicity related studies. We found 429 differentially expressed genes at fold change >2 and p-value <0.05. The most significantly upregulated genes were synuclein alpha (SNCA), carbonic anhyd...περισσότερα »
IJMS, Vol. 17, Pages 257: Deletion of Phytochelatin Synthase Modulates the Metal Accumulation Pattern of Cadmium Exposed C. elegans
Environmental metal pollution is a growing health risk to flora and fauna. It is therefore important to fully elucidate metal detoxification pathways. Phytochelatin synthase (PCS), an enzyme involved in the biosynthesis of phytochelatins (PCs), plays an important role in cadmium detoxification. The PCS and PCs are however not restricted to plants, but are also present in some lower metazoans. The model nematode Caenorhabditis elegans, for example, contains a fully functional phytochelatin synthase and phytochelatin pathway. By means of a transgenic nematode strain expressing a pcs...περισσότερα »
Nutrients, Vol. 8, Pages 104: Cysteic Acid in Dietary Keratin is Metabolized to Glutathione and Liver Taurine in a Rat Model of Human Digestion
Poultry feathers, consisting largely of keratin, are a low-value product of the poultry industry. The safety and digestibility of a dietary protein produced from keratin (KER) was compared to a cysteine-supplemented casein-based diet in a growing rat model for four weeks. KER proved to be an effective substitute for casein at 50% of the total dietary protein, with no changes in the rats' food intake, weight gain, organ weight, bone mineral density, white blood cell counts, liver glutathione, or blood glutathione. Inclusion of KER in the diet reduced total protein digestibility fro... περισσότερα »
IJMS, Vol. 17, Pages 250: Assessment of Radiation Induced Therapeutic Effect and Cytotoxicity in Cancer Patients Based on Transcriptomic Profiling
Toxicity induced by radiation therapy is a curse for cancer patients undergoing treatment. It is imperative to understand and define an ideal condition where the positive effects notably outweigh the negative. We used a microarray meta-analysis approach to measure global gene-expression before and after radiation exposure. Bioinformatic tools were used for pathways, network, gene ontology and toxicity related studies. We found 429 differentially expressed genes at fold change >2 and p-value <0.05. The most significantly upregulated genes were synuclein alpha (SNCA), carbonic anhyd...περισσότερα »
IJERPH, Vol. 13, Pages 240: E-Cigarette as a Harm Reduction Approach among Tobacco Smoking Khat Chewers: A Promising Bullet of Multiple Gains
Khat chewing/use, a green leaf with amphetamine-like effects is socially integrated in the Middle East and Africa. Khat chewing is often associated with tobacco smoking and occurs in closed places, such as a family home setting where the smoke-free laws cannot be implemented. Tobacco cigarette smoking among khat chewers is a significant concern, but there is also second-hand exposure to smoke at home or in places where khat users gather. Evidence suggests that e-cigarettes represent a significantly less harmful form of nicotine intake. Evaluating the effects of e-cigarettes among k...περισσότερα »
Fermentation, Vol. 2, Pages 4: Metabolic Engineering for Production of Small Molecule Drugs: Challenges and Solutions
Production of small molecule drugs in a recombinant host is becoming an increasingly popular alternative to chemical synthesis or production in natural hosts such as plants due to the ease of growing microorganisms with higher titers and less cost. While there are a wide variety of well-developed cloning techniques to produce small molecule drugs in a heterologous host, there are still many challenges towards efficient production. Therefore, this paper reviews some of these recently developed tools for metabolic engineering and categorizes them according to a chronological series ... περισσότερα »
Viruses, Vol. 8, Pages 54: A Toolbox for Herpesvirus miRNA Research: Construction of a Complete Set of KSHV miRNA Deletion Mutants
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes 12 viral microRNAs (miRNAs) that are expressed during latency. Research into KSHV miRNA function has suffered from a lack of genetic systems to study viral miRNA mutations in the context of the viral genome. We used the Escherichia coli Red recombination system together with a new bacmid background, BAC16, to create mutants for all known KSHV miRNAs. The specific miRNA deletions or mutations and the integrity of the bacmids have been strictly quality controlled using PCR, restriction digestion, and sequencing. In addition, sta... περισσότερα »
Narrow band imaging for the diagnosis of head and neck squamous cell carcinoma: A systematic review.
*Narrow band imaging for the diagnosis of head and neck squamous cell carcinoma: A systematic review.* Head Neck. 2016 Feb 18; Authors: Cosway B, Drinnan M, Paleri V Abstract Narrow band imaging (NBI) is reported to improve the diagnostic accuracy of head and neck cancers. The purpose of this review was to evaluate the diagnostic accuracy of NBI in the literature. A systematic review was performed in PubMed, Web of Knowledge, and the Cochrane Library until March 2015. Two reviewers independently assessed articles and extracted data. Meta-analyses were performed in MetaDisc 1.6. F... περισσότερα »
Risk of swallowing-related chest infections in patients with nasopharyngeal carcinoma treated with definitive intensity-modulated radiotherapy.
*Risk of swallowing-related chest infections in patients with nasopharyngeal carcinoma treated with definitive intensity-modulated radiotherapy.* Head Neck. 2016 Feb 18; Authors: Xiong J, Krishnaswamy G, Raynor S, Loh KS, Kwa AL, Lim CM Abstract BACKGROUND: Pulmonary complications secondary to dysphagia may be encountered in patients with nasopharyngeal carcinoma (NPC) after definitive intensity-modulated radiotherapy. The purpose of this study was to identify patients with NPC at risk of developing swallowing-related chest infections (SRCIs). METHODS: Retrospective chart review ... περισσότερα »
Induction docetaxel and S-1 followed by concomitant radiotherapy with low-dose daily cisplatin in locally advanced head and neck carcinoma.
*Induction docetaxel and S-1 followed by concomitant radiotherapy with low-dose daily cisplatin in locally advanced head and neck carcinoma.* Head Neck. 2016 Feb 18; Authors: Kim HR, Lee CG, Choi EC, Kim JH, Koh YW, Cho BC Abstract BACKGROUND: The purpose of this study was to assess the efficacy and safety of induction chemotherapy with docetaxel-S-1, and radiotherapy (RT) with concurrent daily cisplatin in locally advanced head and neck carcinoma. METHOD: Fifty patients received 2 cycles of induction chemotherapy with induction chemotherapy with docetaxel and S-1, followed by 7 cy... περισσότερα »
Association between multidisciplinary team care approach and survival rates in patients with oral cavity squamous cell carcinoma.
*Association between multidisciplinary team care approach and survival rates in patients with oral cavity squamous cell carcinoma.* Head Neck. 2016 Feb 18; Authors: Liao CT, Kang CJ, Lee LY, Hsueh C, Lin CY, Fan KH, Wang HM, Ng SH, Lin CH, Tsao CK, Fang TJ, Huang SF, Chang KP, Chang YL, Yang LY, Yen TC Abstract BACKGROUND: The purpose of this study was to investigate whether multidisciplinary team care (MDTC) is associated with outcomes in oral cavity squamous cell carcinoma (SCC). METHODS: We retrospectively examined 1616 patients with oral cavity SCC who underwent radical surger... περισσότερα »
Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis.
*Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis.* Head Neck. 2016 Feb 18; Authors: Zhang WB, Peng X Abstract Cervical treatment of oral maxillary squamous cell carcinoma (SCC) remains controversial. We determined the metastases incidence and evaluated its predictive factors. Systematic review and meta-analysis was conducted of 23 Chinese and English-language articles retrieved from PubMed, Ovid, Embase, Cochrane Library, China National Knowledge Infrastructure, and Chinese Scientific and Technological Journal databases. Total ...περισσότερα »
Rare cases of benign tumors of the head and neck: lipoma of larynx and sternocleidomastoid muscle.
*Rare cases of benign tumors of the head and neck: lipoma of larynx and sternocleidomastoid muscle.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):118-22 Authors: Demir D, Eraslan Ö, Güven M, Kösem M Abstract In this article, we report two rare cases of lipoma in the head and neck region. Thirty-four-year-old case 1 presented with hoarseness and sensation of foreign body in throat. While 54-year-old case 2 presented with complaint of a mass in left side of neck. The imaging methods showed the masses in false vocal fold and the sternocleidomastoid muscle. Diagnosis and treatmen...περισσότερα »
[Application of special larynx polypus forceps for difficult laryngeal exposure in microlaryngosurgery].
*[Application of special larynx polypus forceps for difficult laryngeal exposure in microlaryngosurgery].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Nov;50(11):948-9 Authors: Deng J, Sima G, Shi F PMID: 26888002 [PubMed - in process] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1Tq6eFr via IFTTT
Cricoid pressure during rapid sequence induction: using the force or not.
Related Articles *Cricoid pressure during rapid sequence induction: using the force or not.* Br J Hosp Med (Lond). 2015 Dec;76(12):730 Authors: Melia D PMID: 26646342 [PubMed - indexed for MEDLINE] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1mLMS0F via IFTTT
Clinical Characteristics of Arytenoid Dislocation After Endotracheal Intubation.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Clinical Characteristics of Arytenoid Dislocation After Endotracheal Intubation.* J Craniofac Surg. 2015 Jun;26(4):1358-60 Authors: Lee DH, Yoon TM, Lee JK, Lim SC Abstract OBJECTIVE: The objective of this study was to review the clinical characteristics of the arytenoid dislocations after the endotracheal intubation and to identify the factors affecting voice recovery in the arytenoid dislocation after the endotracheal intubation. METHODS: A retrospective chart review was performed at Chonnam National University... περισσότερα »
A comparative histopathological study of vocal fold polyps in smokers versus non-smokers.
Related Articles *A comparative histopathological study of vocal fold polyps in smokers versus non-smokers.* J Laryngol Otol. 2015 May;129(5):484-8 Authors: Effat KG, Milad M Abstract BACKGROUND: A large proportion of patients with vocal fold polyps are cigarette smokers. However, prior to this report no comparative study of polyp histopathology in smokers versus non-smokers had been performed. METHODS: A prospective histopathological study of vocal fold polyps excised from 29 patients was undertaken. This comprised a comparative analysis of polyp histopathology in smokers versus...περισσότερα »
A comparison between left molar direct laryngoscopy and the use of a Bonfils intubation fibrescope for tracheal intubation in a simulated difficult airway.
[image: http:--production.springer.de-OnlineReso] Related Articles *A comparison between left molar direct laryngoscopy and the use of a Bonfils intubation fibrescope for tracheal intubation in a simulated difficult airway.* Can J Anaesth. 2015 Jun;62(6):609-17 Authors: Gupta A, Thukral S, Lakra A, Kumar S Abstract BACKGROUND: Tracheal intubation in patients with an immobilized cervical spine can be difficult because of a restricted mouth opening and limited neck movements. Use of the Bonfils intubation fibrescope (BIF) or left molar (LM) laryngoscopy may be suitable options for ... περισσότερα »
Variations of mucosal-sparing septectomy for endonasal approach to the craniocervical junction.
*Variations of mucosal-sparing septectomy for endonasal approach to the craniocervical junction.* Laryngoscope. 2016 Feb 18; Authors: Eloy JA, Vazquez A, Marchiano E, Baredes S, Liu JK Abstract OBJECTIVES/HYPOTHESIS: Recent advances in surgical techniques have rendered the craniocervical junction (CCJ) accessible transnasally. Endoscopic endonasal transclival and transodontoid approaches are routinely performed in leading skull base centers. Usually, these approaches involve a posterior bony and mucosal septectomy, which may compromise the vascularized pedicled nasoseptal flap (P... περισσότερα »
Reconstructive Indications of Anterolateral Thigh Free Flaps in Head and Neck Reconstruction.
*Reconstructive Indications of Anterolateral Thigh Free Flaps in Head and Neck Reconstruction.* Craniomaxillofac Trauma Reconstr. 2016 Mar;9(1):40-5 Authors: Khadakban D, Kudpaje A, Thankappan K, Jayaprasad K, Gorasia T, Vidhyadharan S, Mathew J, Sharma M, Iyer S Abstract Anterolateral thigh (ALT) free flap is a common flap with multitude of indications. The purpose of this article is to review the reconstructive indications of the flap in head and neck defects. This is a retrospective study of 194 consecutive ALT flaps. Data including patient characteristics (age, sex, comorbidi... περισσότερα »
Extragnathic and gnathic odontome.
*Extragnathic and gnathic odontome.* Indian J Dent Res. 2015 Nov-Dec;26(6):641-3 Authors: Sekhar M, Selvaraj L Abstract This is a very rare case report of a multiple odontome involving the upper jaws, lower jaws and an extragnathic site. A thirty seven year-old male complained of missing teeth in his left upper and lower jaw since childhood. Radiographic examination revealed multiple calcified teeth like structures in the left side of the patient's maxilla, mandible and mastoid region of skull base. We arrived at the diagnosis of compound odontome. Patient was otherwise systemica... περισσότερα »
[Surgical anatomy, technique and application of endoscopic endonasal transpterygoid approach in skull base surgery].
*[Surgical anatomy, technique and application of endoscopic endonasal transpterygoid approach in skull base surgery].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Nov;50(11):909-14 Authors: Liu J, Han J, Yang D, Liu D, Li R, Yu Y, Zhang Q, Fernandez Miranda JC, Gardner PA, Snyderman CH Abstract OBJECTIVE: To identify the landmarks of transpterygoid approach and to report its application in a series of cases. METHODS: Two silicon-injected adult cadaveric heads(4 sides) were dissected by performing an endoscopic endonasal transpterygoid approach after CT scanning for imaging... περισσότερα »
Laser biospectroscopy and 5-ALA fluorescence navigation as a helpful tool in the meningioma resection.
*Laser biospectroscopy and 5-ALA fluorescence navigation as a helpful tool in the meningioma resection.* Neurosurg Rev. 2016 Feb 18; Authors: Potapov AA, Goryaynov SA, Okhlopkov VA, Shishkina LV, Loschenov VB, Savelieva TA, Golbin DA, Chumakova AP, Goldberg MF, Varyukhina MD, Spallone A Abstract 5-aminolevulinic acid (5-ALA) is a natural precursor of protoporphyrin IX (PP IX), which possesses fluorescent properties and is more intensively accumulated in tumor cells than in normal tissue. Therefore, the use of 5-ALA in the surgical treatment of intracranial tumors, particularly g... περισσότερα »
A clivus plate fixation for reconstruction of ventral defect of the craniovertebral junction: a novel fixation device for craniovertebral instability.
[image: http:--production.springer.de-OnlineReso] Related Articles *A clivus plate fixation for reconstruction of ventral defect of the craniovertebral junction: a novel fixation device for craniovertebral instability.* Eur Spine J. 2015 Aug;24(8):1658-65 Authors: Ji W, Tong J, Huang Z, Zheng M, Wu X, Chen J, Zhu Q Abstract PURPOSE: A fabricated mesh cage and/or posterior occipitocervical instrumentation alone has been used for reconstruction of ventral defect of the upper cervical spine. However, using a trimmed mesh cage it was hard to achieve optimal clival screw purchase and ... περισσότερα »
Variations of mucosal-sparing septectomy for endonasal approach to the craniocervical junction.
*Variations of mucosal-sparing septectomy for endonasal approach to the craniocervical junction.* Laryngoscope. 2016 Feb 18; Authors: Eloy JA, Vazquez A, Marchiano E, Baredes S, Liu JK Abstract OBJECTIVES/HYPOTHESIS: Recent advances in surgical techniques have rendered the craniocervical junction (CCJ) accessible transnasally. Endoscopic endonasal transclival and transodontoid approaches are routinely performed in leading skull base centers. Usually, these approaches involve a posterior bony and mucosal septectomy, which may compromise the vascularized pedicled nasoseptal flap (P... περισσότερα »
Transdural retrieval of a retropulsed lumbar interbody cage: Technical case report.
*Transdural retrieval of a retropulsed lumbar interbody cage: Technical case report.* Asian J Neurosurg. 2016 Jan-Mar;11(1):71 Authors: Zaidi HA, Shah A, Kakarla UK Abstract The purpose of this case report was to describe a novel method to retrieve a herniated lumbar interbody cage. Transforaminal lumbar interbody fusion (TLIF) is an increasingly popular method of spinal fixation and fusion. Unexpected retropulsion of an interbody is a rare event that can result in intractable pain or motor compromise necessitating surgical retrieval of the interbody. Both anterior and posterior ...περισσότερα »
[Surgical anatomy, technique and application of endoscopic endonasal transpterygoid approach in skull base surgery].
*[Surgical anatomy, technique and application of endoscopic endonasal transpterygoid approach in skull base surgery].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Nov;50(11):909-14 Authors: Liu J, Han J, Yang D, Liu D, Li R, Yu Y, Zhang Q, Fernandez Miranda JC, Gardner PA, Snyderman CH Abstract OBJECTIVE: To identify the landmarks of transpterygoid approach and to report its application in a series of cases. METHODS: Two silicon-injected adult cadaveric heads(4 sides) were dissected by performing an endoscopic endonasal transpterygoid approach after CT scanning for imaging... περισσότερα »
Implications of different patterns of "double-layer sign" in cervical ossification of the posterior longitudinal ligament.
[image: http:--production.springer.de-OnlineReso] Related Articles *Implications of different patterns of "double-layer sign" in cervical ossification of the posterior longitudinal ligament.* Eur Spine J. 2015 Aug;24(8):1631-9 Authors: Yang H, Yang L, Chen D, Wang X, Lu X, Yuan W Abstract PURPOSE: To make a preliminary classification of double-layer sign according to the morphological characteristics of the ossified and central hypodense mass and clarify implications of different patterns of "double-layer sign". METHODS: The 268 patients of cervical ossification of the posterior ... περισσότερα »
Validating the Disruption of Proliferating Cell Nuclear Antigen Interactions in the Development of Targeted Cancer Therapeutics.
*Validating the Disruption of Proliferating Cell Nuclear Antigen Interactions in the Development of Targeted Cancer Therapeutics.* Cancer Biol Ther. 2016 Feb 18;:0 Authors: Smith SJ, Hickey RJ, Malkas LH Abstract Human DNA replication and repair is a highly coordinated process involving the specifically timed actions of numerous proteins and enzymes. Many of these proteins require interaction with proliferating cell nuclear antigen (PCNA) for activation within the process. The interdomain connector loop (IDCL) of PCNA provides a docking site for many of those proteins, suggesting...περισσότερα »
Carcinosarcoma of the upper urinary tract with an aggressive angiosarcoma component.
*Carcinosarcoma of the upper urinary tract with an aggressive angiosarcoma component.* Cancer Biol Ther. 2016 Feb 18;:0 Authors: Urteaga JL, Pous AF, Tapia G, Areal J, Taron M Abstract Carcinosarcomas (CS) are biphasic tumors with malignant epithelial and mesenchymal elements. The sarcomatoid elements of CS can include chondrosarcoma, malignant fibrous histiocytoma, osteosarcoma, leiomyosarcoma, fibrosarcoma, or liposarcoma. CS of the upper urinary tract are extremely rare but are associated with a poor prognosis. We report a case of a 44-year-old man with a localized right renal... περισσότερα »
Rapid induction of apoptosis in chronic lymphocytic leukemia cells by the microtubule disrupting agent BNC105.
*Rapid induction of apoptosis in chronic lymphocytic leukemia cells by the microtubule disrupting agent BNC105.* Cancer Biol Ther. 2016 Jan 30;:1-9 Authors: Bates D, Feris EJ, Danilov AV, Eastman A Abstract Microtubule targeting agents, such as vinblastine, are usually thought to arrest cells in mitosis and subsequently induce apoptosis. However, they can also cause rapid induction of apoptosis in a cell-cycle phase independent manner. BNC105 is a novel vascular and microtubule disrupting drug that also induces apoptosis rapidly but with markedly increased potency compared to vin... περισσότερα »
Validating the Disruption of Proliferating Cell Nuclear Antigen Interactions in the Development of Targeted Cancer Therapeutics.
*Validating the Disruption of Proliferating Cell Nuclear Antigen Interactions in the Development of Targeted Cancer Therapeutics.* Cancer Biol Ther. 2016 Feb 18;:0 Authors: Smith SJ, Hickey RJ, Malkas LH Abstract Human DNA replication and repair is a highly coordinated process involving the specifically timed actions of numerous proteins and enzymes. Many of these proteins require interaction with proliferating cell nuclear antigen (PCNA) for activation within the process. The interdomain connector loop (IDCL) of PCNA provides a docking site for many of those proteins, suggesting...περισσότερα »
Negotiating identity: a qualitative analysis of stigma and support seeking for individuals with cerebral palsy.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Negotiating identity: a qualitative analysis of stigma and support seeking for individuals with cerebral palsy.* Disabil Rehabil. 2015;37(13):1162-9 Authors: Read SA, Morton TA, Ryan MK Abstract PURPOSE: The current research investigates how adults with cerebral palsy construct their personal and social identities in the face of stigma when support seeking, and considers the dilemmas they might face when doing so. METHOD: Participants were 28 adults with cerebral palsy who completed an online survey reporting on their identit...περισσότερα »
Changes in self-reported disability after performance-based tests in obese and non-obese individuals diagnosed with osteoarthritis of the knee.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Changes in self-reported disability after performance-based tests in obese and non-obese individuals diagnosed with osteoarthritis of the knee.* Disabil Rehabil. 2015;37(13):1152-61 Authors: Coriolano K, Aiken A, Pukall C, Harrison M Abstract PURPOSE: The purposes of this study are three-fold: (1) To examine whether the WOMAC questionnaire should be obtained before or after performance-based tests. (2) To assess whether self-reported disability scores before and after performance-based tests differ between obese and non-obes... περισσότερα »
Place attachment in stroke rehabilitation: a transdisciplinary encounter between cultural geography, environmental psychology and rehabilitation medicine.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Place attachment in stroke rehabilitation: a transdisciplinary encounter between cultural geography, environmental psychology and rehabilitation medicine.* Disabil Rehabil. 2015;37(13):1125-34 Authors: Nanninga CS, Meijering L, Schönherr MC, Postema K, Lettinga AT Abstract PURPOSE: To increase understanding of stroke survivor's needs to successfully re-establish attachment to meaningful places at home and in the community. METHODS: Qualitative research methodology including in-depth interviews with stroke survivors in the cl...περισσότερα »
Client-centred practices and work in inpatient rehabilitation teams: results from four case studies.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Client-centred practices and work in inpatient rehabilitation teams: results from four case studies.* Disabil Rehabil. 2015;37(13):1135-43 Authors: Papadimitriou C, Cott C Abstract PURPOSE: To explore the relationship between client-centredness (CC) and work in teams in inpatient rehabilitation. METHODS: Case study, mixed-method design, with strong qualitative component. Methods include ethnographic observations of team and clinical encounters for 6 months; healthcare professional (HCP) interviews. HCP n=45; Observations = 4... περισσότερα »
Crosswalk of participation self-report measures for aphasia to the ICF: what content is being measured?
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Crosswalk of participation self-report measures for aphasia to the ICF: what content is being measured?* Disabil Rehabil. 2015;37(13):1113-24 Authors: Brandenburg C, Worrall L, Rodriguez A, Bagraith K Abstract PURPOSE: Community participation is of importance to people with aphasia, who are at risk of becoming socially isolated. This study investigates the content of measures of community and social participation for this population by crosswalking items to the ICF. This will evaluate: (1) to what extent the included assessm... περισσότερα »
Which dimensions of disability does the HIV Disability Questionnaire (HDQ) measure? A factor analysis.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Which dimensions of disability does the HIV Disability Questionnaire (HDQ) measure? A factor analysis.* Disabil Rehabil. 2015;37(13):1193-201 Authors: O'Brien KK, Bayoumi AM, Stratford P, Solomon P Abstract PURPOSE: To assess the dimensions of disability measured by the HIV Disability Questionnaire (HDQ), a newly developed 72-item self-administered questionnaire that describes the presence, severity and episodic nature of disability experienced by people living with HIV. METHODS: We recruited adults living with HIV from hospi... περισσότερα »
Localized peritoneal carcinomatosis mimicking an irreducible left inguinal hernia.
*Localized peritoneal carcinomatosis mimicking an irreducible left inguinal hernia.* Ann R Coll Surg Engl. 2016 Mar;98(3):e52-e54 Authors: Buchs NC, Bloemendaal A, Guy RJ Abstract Perforated colonic cancers are not rare and leave patients at risk of developing peritoneal carcinomatosis. We present a 68-year-old male patient with a perforated transverse colonic tumour who underwent emergency extended right hemicolectomy. He made an uneventful postoperative recovery, and received adjuvant chemotherapy. Unfortunately, a routine positron emission tomography-computed tomography scan 1... περισσότερα »
A rare gallbladder ciliated foregut cyst in chronic cholecystitis.
*A rare gallbladder ciliated foregut cyst in chronic cholecystitis.* Int J Surg Case Rep. 2016 Jan 22;20:155-158 Authors: Lee MJ, Salinas J, Varikatthas W, Alsnih G Abstract INTRODUCTION: Ciliated foregut cysts (CFC) are rare anomalies due to aberrant embryological development. It is thought to arise from a remnant of the embryologic foregut. The solitary cysts are characterised by ciliated pseudostratified columnar epithelium. They are usually located above the diaphragm but they can also arise in relation to the liver, gallbladder and pancreas. PRESENTATION OF CASE: We present t... περισσότερα »
How Effective Are Percutaneous Liver-Directed Therapies in Patients with Non-Colorectal Liver Metastases?
*How Effective Are Percutaneous Liver-Directed Therapies in Patients with Non-Colorectal Liver Metastases?* Viszeralmedizin. 2015 Dec;31(6):406-13 Authors: Vogl TJ, Emam A, Naguib NN, Eichler K, Zangos S Abstract BACKGROUND: The purpose of this review is to demonstrate the clinical indications, technical developments, and outcome of liver-directed therapies in interventional oncology of non-colorectal liver metastases. METHODS: Liver-directed therapies are classified into vascular transarterial techniques such as chemoperfusion (TACP), chemoembolization (TACE), radioembolization (... περισσότερα »
Low prevalence of HER2 positivity amongst BRCA1 and BRCA2 mutation carriers and in primary BRCA screens.
*Low prevalence of HER2 positivity amongst BRCA1 and BRCA2 mutation carriers and in primary BRCA screens.* Breast Cancer Res Treat. 2016 Feb 18; Authors: Evans DG, Lalloo F, Howell S, Verhoef S, Woodward ER, Howell A Abstract The aim of this study is to delineate more clearly the prevalence of HER2+ breast cancer in women with germline BRCA1/2 mutations. For this purpose, we analysed primary mutation screens on women with breast cancer with unequivocal HER2 amplification and assessed the proportion of BRCA1 and BRCA2 breast cancers that were HER2+ comparing this with the existing ... περισσότερα »
Appendicular mucocele: two case reports and literature review.
*Appendicular mucocele: two case reports and literature review.* G Chir. 2016 Nov-Dec;36(6):276-9 Authors: Anania G, Giaccari S, Solfrini G, Scagliarini L, Vedana L, Resta G Abstract The classification of mucinous tumors of the vermiform appendix is quite controversial, and includes a spectrum of neoplastic lesions ranging from benign proliferations, intraluminal, to invasive adenocarcinomas. Among the complications of appendicular mucinous neoplasms we should mention the "pseudomyxoma peritonei", a condition caused by cancerous cells (mucinous adenocarcinoma) that produce abundan... περισσότερα »
Chronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-Pick type C disease in a mouse model.
*Chronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-Pick type C disease in a mouse model.* Sci Transl Med. 2016 Feb 17;8(326):326ra23 Authors: Alam MS, Getz M, Haldar K Abstract Histone deacetylase inhibitors (HDACi) are approved for treating rare cancers and are of interest as potential therapies for neurodegenerative disorders. We evaluated a triple combination formulation (TCF) comprising the pan-HDACi vorinostat, the caging agent 2-hydroxypropyl-β-cyclodextrin (HPBCD), and polyethylene glycol (PEG) for treating a mouse model (the Npc1(nm... περισσότερα »
TRENDS AND ALTERNATIVES IN TREATMENT OF MALIGNANT TUMORS OF EXTRAHEPATIC BILE DUCTS.
*TRENDS AND ALTERNATIVES IN TREATMENT OF MALIGNANT TUMORS OF EXTRAHEPATIC BILE DUCTS.* Khirurgiia (Sofiia). 2015;81(3):149-60 Authors: Stoyanov V, Dimitrova V Abstract Neoplasms of extrahepatic bile ducts are rare and represent about 2% of all malignant diseases. Their clinical manifestation is delayed, when they are in advanced stage and the opportunities for radical treatment are limited. The resectability rate of the tumors of the middle and distal part of the bile ducts is higher than the percentage of the neoplasms with perihilar localization. Improved methods for preoperati...περισσότερα »
[Thyroid Adenomas in Children].
Related Articles *[Thyroid Adenomas in Children].* Vestn Ross Akad Med Nauk. 2015;(5):513-8 Authors: Morozov DA, Pimenova ES, Mirokova ED Abstract According to the papers thyroid nodules are quite rare in the first two decades of life. However, there are some exceptions, relating to areas with an iodine deficiency or affected by radioactive fallout, where the risk of nodules and carcinomas is increased. Therefore, it is a great challenge for the physician to distinguish between benign and malignant lesions preoperatively, and not only in these areas of greater risk. The authors ... περισσότερα »
Orthokeratinized Odontogenic Cyst: Case of a Rare Peripheral Counterpart.
Related Articles *Orthokeratinized Odontogenic Cyst: Case of a Rare Peripheral Counterpart.* J Calif Dent Assoc. 2015 May;43(5):251-4 Authors: Pakchoian AJ, Mahdian M, Durschlag ME Abstract In this paper, we describe a case of a 57-year-old male with an orthokeratinized odontogenic cyst (OOC), which presented as a diffuse, asymptomatic swelling located on the left posterior aspect of the mandible that together with radiographic and histopathologic findings was diagnosed as a peripheral OOC. PMID: 26798900 [PubMed - indexed for MEDLINE] from #PubMed 3 via ola Kala on Inoreader h... περισσότερα »
Gestational Trophoblastic Neoplasia Metastasis to the Pituitary: A Case Report.
Related Articles *Gestational Trophoblastic Neoplasia Metastasis to the Pituitary: A Case Report.* J Reprod Med. 2015 Nov-Dec;60(11-12):547-52 Authors: Ding H, Tao GS, Fan H, Zhang TT, Liu J Abstract BACKGROUND: Pituitary metastasis secondary to gestational trophoblastic neoplasia (GTN) is an extremely rare condition that has not been previously reported in the literature. CASE: A 23-year-old female presented with symptoms of amenorrhea for 6 months. She was diagnosed with choriocarcinoma, and chemotherapy was scheduled. Three months after drug withdrawal she complained of headac...περισσότερα »
Primary melanoma of the vagina: a case report and review of literature.
Related Articles *Primary melanoma of the vagina: a case report and review of literature.* Eur J Gynaecol Oncol. 2015;36(6):755-7 Authors: Stefanović A, Jeremić J, Jeremić K, Likić I, Mitrović M, Stojnić J Abstract Summary Primary melanoma of the vagina is a rare and very aggressive tumor with an incidence of only 0.46 per one million women per year and less than 250 cases reported in the literature. Here the authors present a case of a 60-year-old woman, gravida 5, para 5, post-menopausal by 28 years, admitted to the Clinic for Obstetrics and Gynecology, with recurrent vaginal b...περισσότερα »
Is gastrointestinal stromal tumor (GIST) originating from the rectovaginal septum GIST or extra-GIST (EGIST)? A case report with literature review.
Related Articles *Is gastrointestinal stromal tumor (GIST) originating from the rectovaginal septum GIST or extra-GIST (EGIST)? A case report with literature review.* Eur J Gynaecol Oncol. 2015;36(6):750-4 Authors: Lee YH, Chong GO, Hong DG Abstract Gastrointestinal stromal tumors (GISTs) are rare tumors of the gastrointestinal (GI) tract that arise from primitive mesenchymal cells. Extragastrointestinal stromal tumors (EGISTs) are extremely rare tumors that show the features of GISTs outside the GI tract. Their most common locations are the omentum, mesentery, and retroperitoneu...περισσότερα »
Ovarian fibrosarcoma: case report and latest trends in diagnostic and therapeutic management.
Related Articles *Ovarian fibrosarcoma: case report and latest trends in diagnostic and therapeutic management.* Eur J Gynaecol Oncol. 2015;36(6):742-5 Authors: Grauso F, Messalli EM, Salzillo ME, Di Martino L, Falcone F, Orabona P, Caiola A, Balbi G Abstract The authors describe a rare case of primary ovarian fibrosarcoma and the latest trends in diagnosis and therapy. The rarity of this dis-ease and the scarce number of reported cases pose serious problems in differentiating it from other fibrous forms. A 58-year-old woman presented intermittent pelvic pain and a demarcated, m...περισσότερα »
Diagnostic usefulness of FDG-PET/CT in advanced malignant lymphoma of the uterus: report of two cases.
Related Articles *Diagnostic usefulness of FDG-PET/CT in advanced malignant lymphoma of the uterus: report of two cases.* Eur J Gynaecol Oncol. 2015;36(6):737-41 Authors: Okuda T, Ijichil S, Yamashita S, Yoshioka T, Nishigaki H, Kitawaki J Abstract Summary Malignant lymphoma of the uterus is difficult to diagnose because of its rarity and nonspecific symptoms. However, recently, 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has become an important non-invasive diagnostic tool for the management of lymphoma patients. The authors report tw... περισσότερα »
Effect of oxygen pressure during incubation with a 10B-carrier on 10B uptake capacity of cultured p53 wild-type and mutated tumor cells: dependency on p53 status of tumor cells and types of 10B-carriers
10.3109/09553002.2016.1137104<br>Shin-ichiro Masunaga from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1osmFFp via IFTTT
Synergistic anti-oral cancer effects of UVC and methanolic extracts of Cryptocarya concinna roots via apoptosis, oxidative stress and DNA damage
10.3109/09553002.2016.1145753<br>Hsueh-Wei Chang from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1osmDgJ via IFTTT
Exposure to a 50-Hz magnetic field induced ceramide generation in cultured cells
10.3109/09553002.2016.1144943<br>Liping Qiu from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1Q57blr via IFTTT
Long-Term use of Modified Dietsin Huntington's Disease: A Descriptive Clinical Practice Analysis on Improving Dietary Enjoyment.
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
*Long-Term use of Modified Dietsin Huntington's Disease: A Descriptive Clinical Practice Analysis on Improving Dietary Enjoyment.* J Huntingtons Dis. 2016 Feb 3; Authors: Moorhouse B, Fisher CA Abstract Dysphagia is a very common occurrence in Huntington's disease (HD). As such, many people with HD require texture modified diets. This commentary discusses the implications for individuals living long-term on modified diets, including the loss of sensory stimulation and dietary enjoyment. Clinical practice analyses of two interventions aimed at promoting dietary satisfaction and in...περισσότερα »
Ageing, Muscle Power and Physical Function: A Systematic Review and Implications for Pragmatic Training Interventions
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Background The physiological impairments most strongly associated with functional performance in older people are logically the most efficient therapeutic targets for exercise training interventions aimed at improving function and maintaining independence in later life. Objectives The objectives of this review were to (1) systematically review the relationship between muscle power and functional performance in older people; (2) systematically review the effect of power training (PT) interventions on functional performance in older people; and (3) identify components of s... περισσότερα »
Endostatin gene therapy inhibits intratumoral macrophage M2 polarization
Publication date: April 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 79 Author(s): Karen Foguer, Marina de Souza Braga, Jean Pierre Schatzmann Peron, Karina Ramalho Bortoluci, Maria Helena Bellini BackgroundRenal cell carcinoma (RCC) is a highly vascularized cancer resistant to chemotherapy and radiotherapy. RCC is frequently infiltrated with immune cells, with macrophages being the most abundant cell type. Alternatively activated M2 macrophages are known to contribute to tumor progression. Endostatin (ES) is a fragment of collagen XVIII that possesses antiangiogenic activity... περισσότερα »
Pristimerin inhibits proliferation, migration and invasion, and induces apoptosis in HCT-116 colorectal cancer cells
Publication date: April 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 79 Author(s): Bashir A. Yousef, Hozeifa M. Hassan, Mounia Guerram, Aida M. Hamdi, Bin Wang, Lu-Yong Zhang, Zhen-Zhou Jiang Colorectal cancer (CRC) is one of the world's most common cancers with a high mortality rate mainly due to metastasis. Our previous study showed that pristimerin had potent antitumor activities against human CRC cells. In the present study, we further evaluated pristimerin anti-tumor and anti-metastatic properties. MTT assay, Hoechst staining, Annexin V/PI double staining, reactive oxyge... περισσότερα »
[Cinical and genetic characteristics of familial Meniere's disease: three families report].
*[Cinical and genetic characteristics of familial Meniere's disease: three families report].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Nov;50(11):915-24 Authors: Gao Y, Wang D, Wang H, Guan J, Lan L, Wu Z, Xie L, Yu L, Zhang S, Shan X, Wang Q Abstract OBJECTIVE: To investigate the clinical and genetic characteristics of three Chinese Meniere's disease(MD) families and decipher the mechanism of MD further. METHODS: Personal and family medical evidence of hearing loss, vestibular symptoms, and other clinical abnormalities of the participants were identified, clinical and...περισσότερα »
An update on civilian spinal gunshot wounds: treatment, neurological recovery, and complications.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *An update on civilian spinal gunshot wounds: treatment, neurological recovery, and complications.* Spine (Phila Pa 1976). 2015 Apr 1;40(7):450-61 Authors: Bumpass DB, Buchowski JM, Park A, Gray BL, Agarwal R, Baty J, Zebala LP, Riew KD, Santiago P, Ray WZ, Wright NM Abstract STUDY DESIGN: Retrospective analysis of inpatient and outpatient data from a single academic trauma center. OBJECTIVE: To test the effectiveness of a conservative treatment algorithm for civilian spinal gunshot wounds (CSGSWs) by comprehensive... περισσότερα »
[Outpatient surgical practices in otorhinolaryngology].
*[Outpatient surgical practices in otorhinolaryngology].* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):123-8 Authors: Kurtoğlu G, Erdağ TK Abstract OBJECTIVES: In this study, we report outpatient surgical procedures in an ear nose and throat (ENT) clinic of a university hospital for the first time in Turkey. MATERIAL AND METHODS: All patients who were operated between January 2012 and December 2013 by our ENT surgeons either in central operating room or in outpatient surgery unit were retrospectively analyzed. Age of the patients, type of operation, type of anesthesia, and the...περισσότερα »
Rare cases of benign tumors of the head and neck: lipoma of larynx and sternocleidomastoid muscle.
*Rare cases of benign tumors of the head and neck: lipoma of larynx and sternocleidomastoid muscle.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):118-22 Authors: Demir D, Eraslan Ö, Güven M, Kösem M Abstract In this article, we report two rare cases of lipoma in the head and neck region. Thirty-four-year-old case 1 presented with hoarseness and sensation of foreign body in throat. While 54-year-old case 2 presented with complaint of a mass in left side of neck. The imaging methods showed the masses in false vocal fold and the sternocleidomastoid muscle. Diagnosis and treatmen...περισσότερα »
Unilateral sudden hearing loss: a rare symptom of Moyamoya disease.
*Unilateral sudden hearing loss: a rare symptom of Moyamoya disease.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):114-7 Authors: Gül F, Berçin S, Müderris T, Yalçıner G, Ünal Ö, Kırış M Abstract A 38-year-old female patient experienced a sudden onset of unilateral sensorineural hearing loss due to Moyamoya disease. A detailed summary of audiological and neurological findings indicated that the sudden hearing loss might be due to Moyamoya disease resulting in occlusion of posterior and middle cerebral arteries. Intravenous prednisolone and trimetazidine dihydrochloride may imp...περισσότερα »
Effect of oxygen pressure during incubation with a 10B-carrier on 10B uptake capacity of cultured p53 wild-type and mutated tumor cells: dependency on p53 status of tumor cells and types of 10B-carriers
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
10.3109/09553002.2016.1137104<br>Shin-ichiro Masunaga from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1osmFFp via IFTTT
Synergistic anti-oral cancer effects of UVC and methanolic extracts of Cryptocarya concinna roots via apoptosis, oxidative stress and DNA damage
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
10.3109/09553002.2016.1145753<br>Hsueh-Wei Chang from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1osmDgJ via IFTTT
Exposure to a 50-Hz magnetic field induced ceramide generation in cultured cells
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
10.3109/09553002.2016.1144943<br>Liping Qiu from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Q57blr via IFTTT
Hyperocclusion stimulates the expression of collagen type XII in periodontal ligament
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 18 February 2016 Source:Archives of Oral Biology Author(s): Takashi Tsuzuki, Hiroshi Kajiya, Kazuko T-Goto, Takashi Tsutsumi, Tetsuomi Nemoto, Koji Okabe, Yutaka Takahashi ObjectivesIt is known that excessive mechanical force exerted by hyperocclusion induces occlusal trauma. However, the mechanism of the process remains unclear. In the present study, we employed an in […]
Non-melanoma skin cancer of the head and neck: the aid of reflectance confocal microscopy for the accurate diagnosis and management.
*Non-melanoma skin cancer of the head and neck: the aid of reflectance confocal microscopy for the accurate diagnosis and management.* G Ital Dermatol Venereol. 2016 Feb 18; Authors: Ferrari B, Salgarelli AC, Mandel VD, Bellini P, Reggiani C, Farnetani F, Pellacani G, Magnoni C Abstract BACKGOUND: Non-melanoma skin cancer (NMSC) represents the most common cutaneous neoplasms of the head and neck. In recent years, novel non-invasive diagnostic tool have been developed, and among these we have the reflectance confocal microscopy (RCM), that offers the evaluation of the skin at real... περισσότερα »
Visual perception of upright: Head tilt, visual errors and viewing eye.
*Visual perception of upright: Head tilt, visual errors and viewing eye.* J Vestib Res. 2016 Jan 28;25(5-6):201-209 Authors: Kheradmand A, Gonzalez G, Otero-Millan J, Lasker A Abstract BACKGROUND: Perception of upright is often assessed by aligning a luminous line to the subjective visual vertical (SVV). OBJECTIVE: Here we investigated the effects of visual line rotation and viewing eye on SVV responses and whether there was any change with head tilt. METHODS: SVV was measured using a forced-choice paradigm and by combining the following conditions in 22 healthy subjects: head posi...περισσότερα »
Matricellular Protein Periostin Mediates Intestinal Inflammation through the Activation of Nuclear Factor κB Signaling.
*Matricellular Protein Periostin Mediates Intestinal Inflammation through the Activation of Nuclear Factor κB Signaling.* PLoS One. 2016;11(2):e0149652 Authors: Koh SJ, Choi Y, Kim BG, Lee KL, Kim DW, Kim JH, Kim JW, Kim JS Abstract Periostin is a matricellular protein that interacts with various integrin molecules on the cell surface. Although periostin is expressed in inflamed colonic mucosa, its role in the regulation of intestinal inflammation remains unclear. We investigated the role of periostin in intestinal inflammation using Postn-deficient (Postn-/-) mice. Intestinal epi... περισσότερα »
Neuronavigated left temporal continuous theta burst stimulation in chronic tinnitus.
*Neuronavigated left temporal continuous theta burst stimulation in chronic tinnitus.* Restor Neurol Neurosci. 2016 Jan 30; Authors: Schecklmann M, Giani A, Tupak S, Langguth B, Raab V, Polak T, Várallyay C, Harnisch W, Herrmann MJ, Fallgatter AJ Abstract PURPOSE: Clinical effects of repetitive transcranial magnetic stimulation (rTMS) in chronic tinnitus are moderate. More precise coil localisation strategies, innovative stimulation protocols, and identification of predictors for treatment response were proposed as promising attempts to enhance treatment efficacy. In this pilot s... περισσότερα »
Mandarin Tone Identification in Cochlear Implant Users Using Exaggerated Pitch Contours.
*Mandarin Tone Identification in Cochlear Implant Users Using Exaggerated Pitch Contours.* Otol Neurotol. 2016 Feb 15; Authors: He A, Deroche ML, Doong J, Jiradejvong P, Limb CJ Abstract OBJECTIVE: To determine whether exaggerating the variations in fundamental frequency (F0) contours of Mandarin-based pitch fluctuations could improve tone identification by cochlear implant (CI) users. METHODS: Twelve normal-hearing (NH) listeners and 11 CI users were tested for their ability to recognize F0 contours modeled after Mandarin tones, in 4- or 5-alternatives forced-choice paradigms. Tw... περισσότερα »
Secondary Structures in Inorganic Helicates of an Octadentate Phenanthroline-Type Schiff Base Ligand
Abstract To analyze the contribution of supramolecular interactions to helical architectures and to investigate whether ligand folding can be induced by only protons in a similar fashion in the absence of metal ions, a new 1,10-phenanthroline (phen)-based extended ligand, C12H6N2[CHNC6H4NH(C10H6N)] 2 (L1), its copper(I) complexes, [Cu2(C12H6N2{CHNC6H4NH(C10H6N)}2)2] [PF6]2 (*1*), [Cu2(C12H6N2{CHNC6H4NH(C10H6N)}2)2][BF4]2 (*2*), [Cu2(C12H6N2{CHNC6H4 NH(C10H6N)}2)2][CuCl2]2*·*CH2Cl2 (*3*), and [Cu4(C12H6N2{CHNC6H4NH(C10H6N)}2 )2][Cu2I4] (*4*), were prepared and structurally characterize... περισσότερα »
Cationic BPI-Gold(III) Complexes: Controlling Ligating and Nonligating Anions
Abstract A new synthetic protocol has been devised to access cationic gold(III) bis(2-pyridylimino)isoindolato (BPI) complexes. The rigid BPI framework was shown to stabilize this type of coordination compound and allowed different substitution patterns in the ligand periphery. The synthesis of these complexes tolerates both air and moisture and does not require transmetalation steps with toxic thallium or mercury compounds. Notably, control of the counterion was achieved through the use of an ion-exchange resin and salt metathesis. The selective modification and transformation of ...περισσότερα »
Rabdomiosarcoma infantile, scoperta l’alterazione genetica per diagnosticarlo
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
I tumori congeniti e del primo anno di vita sono difficili da diagnosticare perché rari e difficili da curare. Il rabdomiosarcoma rappresenta il più frequente sarcoma dell’età pediatrica… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Tu86OF via IFTTT
Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Klebsiella pneumoniae is a common cause of hospital-acquired pneumonia. Granzymes (gzms), mainly found in cytotoxic lymphocytes, have been implicated as mediators of infection and inflammation. We here sought to investigate the role of gzmA and gzmB in the host response to K. pneumoniae-induced airway infection and sepsis. For this purpose, pneumonia was induced in wild-type […]
Viruses, Vol. 8, Pages 54: A Toolbox for Herpesvirus miRNA Research: Construction of a Complete Set of KSHV miRNA Deletion Mutants
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes 12 viral microRNAs (miRNAs) that are expressed during latency. Research into KSHV miRNA function has suffered from a lack of genetic systems to study viral miRNA mutations in the context of the viral genome. We used the Escherichia coli Red recombination system together with a new bacmid background, BAC16, to […]
If Chemotherapy Is Indicated, Give the Optimal Regimen!
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Breast Care from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Tu86hD via IFTTT
IJERPH, Vol. 13, Pages 241: Sex and Age Differences in Exposure to Secondhand Smoke at Home among Korean Adolescents: A Nationally Representative Survey
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The authors assessed sex and age differences in secondhand smoke (SHS) exposure among vulnerable adolescent populations. Data from the 2013 Korea Youth Risk Behavior Web-based Survey of 64,499 non-smokers aged 13–18 years were analyzed using multiple logistic regression. Girls were exposed 1.26 times (95% confidence interval, 1.21–1.32) more to home SHS than boys, and the […]
IJERPH, Vol. 13, Pages 240: E-Cigarette as a Harm Reduction Approach among Tobacco Smoking Khat Chewers: A Promising Bullet of Multiple Gains
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Khat chewing/use, a green leaf with amphetamine-like effects is socially integrated in the Middle East and Africa. Khat chewing is often associated with tobacco smoking and occurs in closed places, such as a family home setting where the smoke-free laws cannot be implemented. Tobacco cigarette smoking among khat chewers is a significant concern, but there […]
How do scientists perceive the current publication culture? A qualitative focus group interview study among Dutch biomedical researchers.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
How do scientists perceive the current publication culture? A qualitative focus group interview study among Dutch biomedical researchers. BMJ Open. 2016;6(2):e008681 Authors: Tijdink JK, Schipper K, Bouter LM, Maclaine Pont P, de Jonge J, Smulders YM Abstract OBJECTIVE: To investigate the biomedical scientist’s perception of the prevailing publication culture. DESIGN: Qualitative focus group interview study. […]
Cleft Lip Cleft Palate and Craniofacial Deformities Care: An Anesthesiologist’s Perspective at the Tawanchai Center.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Related Articles Cleft Lip Cleft Palate and Craniofacial Deformities Care: An Anesthesiologist’s Perspective at the Tawanchai Center. J Med Assoc Thai. 2015 Aug;98 Suppl 7:S33-7 Authors: Thongrong C, Sriraj W, Rojanapithayakorn N, Bunsangjaroen P, Kasemsiri P Abstract BACKGROUND: The increasing number of pediatric patients with cleft lip-palate and craniofacial anomalies is a nuisance problem in […]
Nursing and Daoism: Wading in the River of Practice.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Related Articles Nursing and Daoism: Wading in the River of Practice. Creat Nurs. 2015;21(4):245-9 Authors: Chung S, Fitzsimons V Abstract The study of philosophy has shaped and continues to shape thinking in many disciplines. One may not initially associate philosophy with a grounding idea in the nursing profession; however, its ideas fit the contour of […]
The Promise of Integrative Nursing.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Related Articles The Promise of Integrative Nursing. Creat Nurs. 2015;21(4):193-9 Authors: Koithan M Abstract The U.S. health care system requires transformative changes that reduce risk and improve overall well-being while increasing access, quality, safety, and affordability. Integrative nursing can serve as a road map to care that is culturally safe, personalized, and meaningful. Using exemplar […]
An update on civilian spinal gunshot wounds: treatment, neurological recovery, and complications.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *An update on civilian spinal gunshot wounds: treatment, neurological recovery, and complications.* Spine (Phila Pa 1976). 2015 Apr 1;40(7):450-61 Authors: Bumpass DB, Buchowski JM, Park A, Gray BL, Agarwal R, Baty J, Zebala LP, Riew KD, Santiago P, Ray WZ, Wright NM Abstract STUDY DESIGN: Retrospective analysis of inpatient and outpatient data from a single academic trauma center. OBJECTIVE: To test the effectiveness of a conservative treatment algorithm for civilian spinal gunshot wounds (CSGSWs) by comprehensive... περισσότερα »
[Outpatient surgical practices in otorhinolaryngology].
*[Outpatient surgical practices in otorhinolaryngology].* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):123-8 Authors: Kurtoğlu G, Erdağ TK Abstract OBJECTIVES: In this study, we report outpatient surgical procedures in an ear nose and throat (ENT) clinic of a university hospital for the first time in Turkey. MATERIAL AND METHODS: All patients who were operated between January 2012 and December 2013 by our ENT surgeons either in central operating room or in outpatient surgery unit were retrospectively analyzed. Age of the patients, type of operation, type of anesthesia, and the...περισσότερα »
Rare cases of benign tumors of the head and neck: lipoma of larynx and sternocleidomastoid muscle.
*Rare cases of benign tumors of the head and neck: lipoma of larynx and sternocleidomastoid muscle.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):118-22 Authors: Demir D, Eraslan Ö, Güven M, Kösem M Abstract In this article, we report two rare cases of lipoma in the head and neck region. Thirty-four-year-old case 1 presented with hoarseness and sensation of foreign body in throat. While 54-year-old case 2 presented with complaint of a mass in left side of neck. The imaging methods showed the masses in false vocal fold and the sternocleidomastoid muscle. Diagnosis and treatmen...περισσότερα »
Unilateral sudden hearing loss: a rare symptom of Moyamoya disease.
*Unilateral sudden hearing loss: a rare symptom of Moyamoya disease.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):114-7 Authors: Gül F, Berçin S, Müderris T, Yalçıner G, Ünal Ö, Kırış M Abstract A 38-year-old female patient experienced a sudden onset of unilateral sensorineural hearing loss due to Moyamoya disease. A detailed summary of audiological and neurological findings indicated that the sudden hearing loss might be due to Moyamoya disease resulting in occlusion of posterior and middle cerebral arteries. Intravenous prednisolone and trimetazidine dihydrochloride may imp...περισσότερα »
Well differentiated papillary carcinoma of thyroid presenting as metastatic liver mass.
*Well differentiated papillary carcinoma of thyroid presenting as metastatic liver mass.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):109-13 Authors: Mishra B, Tandon A, Wadhwa N, Mehrotra G, Bhatt S, Rajaram S Abstract Well differentiated papillary carcinoma of thyroid frequently metastasizes to regional lymph nodes and the patients usually present with cervical or mediastinal lymphadenopathy. In this article, we report a case of papillary thyroid carcinoma with hepatic metastasis presenting as liver mass in absence of lymph nodal metastasis, a presentation not previously re...περισσότερα »
Voice evaluation in asthma patients using inhaled corticosteroids.
*Voice evaluation in asthma patients using inhaled corticosteroids.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):101-8 Authors: Hassen HE, Abo Hasseba AM Abstract OBJECTIVES: This study aims to assess voice changes and laryngeal abnormalities in asthmatic patients using inhaled corticosteroids (ICSs). PATIENTS AND METHODS: This study included 30 patients (15 females; mean age 21.3±2.6 years; range, 17 to 26 years and 15 males; mean age 20.7±2.3 years; range, 16 to 27 years) with bronchial asthma treated with ICSs between May 2013 and December 2013. A speech sample from each pa... περισσότερα »
Assessment of nasal airway patency during pregnancy and postpartum period: correlation between subjective and objective techniques.
*Assessment of nasal airway patency during pregnancy and postpartum period: correlation between subjective and objective techniques.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):92-100 Authors: Karataş M, Çam OH, Tekin M Abstract OBJECTIVES: This study aims to determine the physiological changes in a pregnant woman's nasal airway, the frequency of pregnancy rhinitis, and the correlation among anterior rhinoscopy (AnR), anterior rhinomanometry (ARM), and subjective nasal obstruction score as she progresses through pregnancy into the postpartum period (PPP). PATIENTS AND METHOD... περισσότερα »
[Relationship between preoperative patient learning need and anxiety of patients hospitalized at Ear Nose Throat and Head Neck Surgery clinic for surgical treatment].
*[Relationship between preoperative patient learning need and anxiety of patients hospitalized at Ear Nose Throat and Head Neck Surgery clinic for surgical treatment].* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):79-91 Authors: Vermişli S, Çukurova İ, Baydur H, Yılmaz E Abstract OBJECTIVES: This study aims to evaluate the relationship between preoperative patient learning need and anxiety in patients hospitalized at Ear Nose Throat and Head Neck Surgery (ENT and HNS) clinic for surgical treatment. PATIENTS AND METHODS: The study sample comprised 98 patients (56 males, 42 fem...περισσότερα »
Pepsinogen identification in the middle ear fluid of children with otitis media with effusion.
*Pepsinogen identification in the middle ear fluid of children with otitis media with effusion.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):73-8 Authors: Buyruk A, Osma Ü, Yılmaz MD, Eyigör H Abstract OBJECTIVES: This study aims to investigate the presence and concentration of pepsin/pepsinogen in middle ear fluid and to discuss the potential mechanisms involved in the pathogenesis of this condition. PATIENTS AND METHODS: A total of 33 children (21 boys, 12 girls; mean age 5.7±2.4 years; range 3 to 13 years) diagnosed with otitis media with effusion and scheduled for operati...περισσότερα »
Effect of laryngopharyngeal reflux on the improvement of chronic rhinosinusitis without polyposis after primary endoscopic sinus surgery.
*Effect of laryngopharyngeal reflux on the improvement of chronic rhinosinusitis without polyposis after primary endoscopic sinus surgery.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):65-72 Authors: Verim A, Şeneldir L, Naiboğlu B, Tepe Karaca Ç, Kadıoğlu D, Zer Toros S Abstract OBJECTIVES: This study aims to investigate the influence of laryngopharyngeal reflux on the improvement of chronic rhinosinusitis (CRS) in patients who underwent endoscopic sinus surgery (ESS). PATIENTS AND METHODS: A total of 48 patients (28 males, 20 females; mean age 41.6±15.1 years; range 18 to 75... περισσότερα »
[Outpatient surgical practices in otorhinolaryngology].
*[Outpatient surgical practices in otorhinolaryngology].* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):123-8 Authors: Kurtoğlu G, Erdağ TK Abstract OBJECTIVES: In this study, we report outpatient surgical procedures in an ear nose and throat (ENT) clinic of a university hospital for the first time in Turkey. MATERIAL AND METHODS: All patients who were operated between January 2012 and December 2013 by our ENT surgeons either in central operating room or in outpatient surgery unit were retrospectively analyzed. Age of the patients, type of operation, type of anesthesia, and the...περισσότερα »
Rare cases of benign tumors of the head and neck: lipoma of larynx and sternocleidomastoid muscle.
*Rare cases of benign tumors of the head and neck: lipoma of larynx and sternocleidomastoid muscle.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):118-22 Authors: Demir D, Eraslan Ö, Güven M, Kösem M Abstract In this article, we report two rare cases of lipoma in the head and neck region. Thirty-four-year-old case 1 presented with hoarseness and sensation of foreign body in throat. While 54-year-old case 2 presented with complaint of a mass in left side of neck. The imaging methods showed the masses in false vocal fold and the sternocleidomastoid muscle. Diagnosis and treatmen...περισσότερα »
Unilateral sudden hearing loss: a rare symptom of Moyamoya disease.
*Unilateral sudden hearing loss: a rare symptom of Moyamoya disease.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):114-7 Authors: Gül F, Berçin S, Müderris T, Yalçıner G, Ünal Ö, Kırış M Abstract A 38-year-old female patient experienced a sudden onset of unilateral sensorineural hearing loss due to Moyamoya disease. A detailed summary of audiological and neurological findings indicated that the sudden hearing loss might be due to Moyamoya disease resulting in occlusion of posterior and middle cerebral arteries. Intravenous prednisolone and trimetazidine dihydrochloride may imp...περισσότερα »
Well differentiated papillary carcinoma of thyroid presenting as metastatic liver mass.
*Well differentiated papillary carcinoma of thyroid presenting as metastatic liver mass.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):109-13 Authors: Mishra B, Tandon A, Wadhwa N, Mehrotra G, Bhatt S, Rajaram S Abstract Well differentiated papillary carcinoma of thyroid frequently metastasizes to regional lymph nodes and the patients usually present with cervical or mediastinal lymphadenopathy. In this article, we report a case of papillary thyroid carcinoma with hepatic metastasis presenting as liver mass in absence of lymph nodal metastasis, a presentation not previously re...περισσότερα »
Voice evaluation in asthma patients using inhaled corticosteroids.
*Voice evaluation in asthma patients using inhaled corticosteroids.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):101-8 Authors: Hassen HE, Abo Hasseba AM Abstract OBJECTIVES: This study aims to assess voice changes and laryngeal abnormalities in asthmatic patients using inhaled corticosteroids (ICSs). PATIENTS AND METHODS: This study included 30 patients (15 females; mean age 21.3±2.6 years; range, 17 to 26 years and 15 males; mean age 20.7±2.3 years; range, 16 to 27 years) with bronchial asthma treated with ICSs between May 2013 and December 2013. A speech sample from each pa... περισσότερα »
Assessment of nasal airway patency during pregnancy and postpartum period: correlation between subjective and objective techniques.
*Assessment of nasal airway patency during pregnancy and postpartum period: correlation between subjective and objective techniques.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):92-100 Authors: Karataş M, Çam OH, Tekin M Abstract OBJECTIVES: This study aims to determine the physiological changes in a pregnant woman's nasal airway, the frequency of pregnancy rhinitis, and the correlation among anterior rhinoscopy (AnR), anterior rhinomanometry (ARM), and subjective nasal obstruction score as she progresses through pregnancy into the postpartum period (PPP). PATIENTS AND METHOD... περισσότερα »
[Relationship between preoperative patient learning need and anxiety of patients hospitalized at Ear Nose Throat and Head Neck Surgery clinic for surgical treatment].
*[Relationship between preoperative patient learning need and anxiety of patients hospitalized at Ear Nose Throat and Head Neck Surgery clinic for surgical treatment].* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):79-91 Authors: Vermişli S, Çukurova İ, Baydur H, Yılmaz E Abstract OBJECTIVES: This study aims to evaluate the relationship between preoperative patient learning need and anxiety in patients hospitalized at Ear Nose Throat and Head Neck Surgery (ENT and HNS) clinic for surgical treatment. PATIENTS AND METHODS: The study sample comprised 98 patients (56 males, 42 fem...περισσότερα »
Pepsinogen identification in the middle ear fluid of children with otitis media with effusion.
*Pepsinogen identification in the middle ear fluid of children with otitis media with effusion.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):73-8 Authors: Buyruk A, Osma Ü, Yılmaz MD, Eyigör H Abstract OBJECTIVES: This study aims to investigate the presence and concentration of pepsin/pepsinogen in middle ear fluid and to discuss the potential mechanisms involved in the pathogenesis of this condition. PATIENTS AND METHODS: A total of 33 children (21 boys, 12 girls; mean age 5.7±2.4 years; range 3 to 13 years) diagnosed with otitis media with effusion and scheduled for operati...περισσότερα »
Effect of laryngopharyngeal reflux on the improvement of chronic rhinosinusitis without polyposis after primary endoscopic sinus surgery.
*Effect of laryngopharyngeal reflux on the improvement of chronic rhinosinusitis without polyposis after primary endoscopic sinus surgery.* Kulak Burun Bogaz Ihtis Derg. 2016 Mar-Apr;26(2):65-72 Authors: Verim A, Şeneldir L, Naiboğlu B, Tepe Karaca Ç, Kadıoğlu D, Zer Toros S Abstract OBJECTIVES: This study aims to investigate the influence of laryngopharyngeal reflux on the improvement of chronic rhinosinusitis (CRS) in patients who underwent endoscopic sinus surgery (ESS). PATIENTS AND METHODS: A total of 48 patients (28 males, 20 females; mean age 41.6±15.1 years; range 18 to 75... περισσότερα »
[Cinical and genetic characteristics of familial Meniere's disease: three families report].
*[Cinical and genetic characteristics of familial Meniere's disease: three families report].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Nov;50(11):915-24 Authors: Gao Y, Wang D, Wang H, Guan J, Lan L, Wu Z, Xie L, Yu L, Zhang S, Shan X, Wang Q Abstract OBJECTIVE: To investigate the clinical and genetic characteristics of three Chinese Meniere's disease(MD) families and decipher the mechanism of MD further. METHODS: Personal and family medical evidence of hearing loss, vestibular symptoms, and other clinical abnormalities of the participants were identified, clinical and...περισσότερα »
RT @eurordis : Call for launch of 3rd French #raredisease plan at @rarediseaseday press conference #appelplan3 @AllianceMR https://t.co/jk8…
RT @eurordis : Call for launch of 3rd French #raredisease plan at @rarediseaseday press conference #appelplan3 @AllianceMR https://t.co/jk8… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/700631302932811776 via IFTTT
Fermentation, Vol. 2, Pages 4: Metabolic Engineering for Production of Small Molecule Drugs: Challenges and Solutions
Production of small molecule drugs in a recombinant host is becoming an increasingly popular alternative to chemical synthesis or production in natural hosts such as plants due to the ease of growing microorganisms with higher titers and less cost. While there are a wide variety of well-developed cloning techniques to produce small molecule drugs in… Continue reading Fermentation, Vol. 2, Pages 4: Metabolic Engineering for Production of Small Molecule Drugs: Challenges and Solutions
Signaling via the CytoR/JAK/STAT/SOCS pathway: Emergence during evolution
Publication date: March 2016 Source:Molecular Immunology, Volume 71 Author(s): Clifford Liongue, Tarannum Taznin, Alister C. Ward Cell–cell signaling represents an essential hallmark of multicellular organisms, which necessarily require a means of communicating between different cell populations, particularly immune cells. Cytokine receptor signaling through the Janus kinase/Signal Transducer and Activator of Transcription/Suppressor of Cytokine Signaling (CytoR/JAK/STAT/SOCS)… Continue reading Signaling via the CytoR/JAK/STAT/SOCS pathway: Emergence during evolution
Viruses, Vol. 8, Pages 54: A Toolbox for Herpesvirus miRNA Research: Construction of a Complete Set of KSHV miRNA Deletion Mutants
Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes 12 viral microRNAs (miRNAs) that are expressed during latency. Research into KSHV miRNA function has suffered from a lack of genetic systems to study viral miRNA mutations in the context of the viral genome. We used the Escherichia coli Red recombination system together with a new bacmid background, BAC16, to… Continue reading Viruses, Vol. 8, Pages 54: A Toolbox for Herpesvirus miRNA Research: Construction of a Complete Set of KSHV miRNA Deletion Mutants
C1 Inhibitor as a glycoprotein: The influence of polysaccharides on its function and autoantibody target
Publication date: March 2016 Source:Molecular Immunology, Volume 71 Author(s): Arije Ghannam, Pauline Sellier, Olivier Fain, Ludovic Martin, Denise Ponard, Christian Drouet C1 Inhibitor (C1Inh), a member of the Serine proteinase inhibitor family, is the most heavily glycosylated plasma protein. This work investigated the impact of C1Inh glycosylation on its function regarding protease targets and autoantibody… Continue reading C1 Inhibitor as a glycoprotein: The influence of polysaccharides on its function and autoantibody target
RT @RCSnews : RCS One Year Fellowship – Deadline for applications is Monday 29th @3pm https://t.co/xUCxkeQzsV https://t.co/U9peqyXNH8
RT @RCSnews : RCS One Year Fellowship – Deadline for applications is Monday 29th @3pm https://t.co/xUCxkeQzsV https://t.co/U9peqyXNH8 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/700631241222017025 via IFTTT
Exercise-induced oxidative stress: past, present and future
Abstract The existence of free radicals in living cells was first reported in 1954 and this important finding helped launch the field of free radical biology. However, the discovery that muscular exercise is associated with increased biomarkers of oxidative stress did not occur until 1978. Following the initial report that exercise promotes oxidative stress in… Continue reading Exercise-induced oxidative stress: past, present and future
What factors affect non-compliance with endocrine therapy among young women with breast cancer? https://t.co/ZQhFNrohA1
What factors affect non-compliance with endocrine therapy among young women with breast cancer? https://t.co/ZQhFNrohA1 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/700627867529445377 via IFTTT
Researchers Make Progress in Genomic Classification of Bladder Cancers
Investigators from seven centers of excellence from around the world met at the Spanish National Cancer Research Centre-CNIO (Madrid, Spain) in 2015. Each group, having proposed a genome-based molecular taxonomy of urothelial bladder cancer (UBC), recognized the value of an agreement that could then help facilitate progress in the field and stimulate collaboration. Lead author… Continue reading Researchers Make Progress in Genomic Classification of Bladder Cancers
Learn palliative care in our new online course for Indian healthcare professionals https://t.co/1XsbJMCQ99 https://t.co/iQy34u4o2B
Learn palliative care in our new online course for Indian healthcare professionals https://t.co/1XsbJMCQ99 https://t.co/iQy34u4o2B from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/700623390189740032 via IFTTT
Vocational rehabilitation case manager factors associated with vocational rehabilitation service program outcomes for people with disabilities in Taiwan - an exploratory study.
*Vocational rehabilitation case manager factors associated with vocational rehabilitation service program outcomes for people with disabilities in Taiwan - an exploratory study.* Disabil Rehabil. 2016 Feb 18;:1-7 Authors: Wang YT, Lin YJ Abstract Purpose The aim of this study is to explore whether/which vocational rehabilitation case manager (VRCMer) factors were significantly associated with the vocational rehabilitation service (VRS) program outcomes in Taiwan. Method This study used the 2011 VRS Program for People with Disabilities Database in a metropolitan city in Taiwan (N ... περισσότερα »
Discourse level reading comprehension interventions following acquired brain injury: a systematic review.
*Discourse level reading comprehension interventions following acquired brain injury: a systematic review.* Disabil Rehabil. 2016 Feb 18;:1-23 Authors: Watter K, Copley A, Finch E Abstract Purpose Reading comprehension can change following acquired brain injury (ABI), impacting independence and participation. This review aims to identify and evaluate the interventions used for rehabilitation of discourse level reading in adults with ABI. Methods A systematic review was conducted of published journal articles. Methodological quality of studies was reviewed using formal and informa...περισσότερα »
Coronectomy for the mandibular third molar: Respect for the inferior alveolar nerve
The aim of this study was to evaluate the outcomes of coronectomy as an alternative surgical procedure to complete removal of the impacted mandibular third molar in patients with a suspected close relationship between the tooth root(s) and the mandibular canal. A total of 151 patients underwent coronectomy and were followed up with clinical examinations… Continue reading Coronectomy for the mandibular third molar: Respect for the inferior alveolar nerve
Antioxidants, Vol. 5, Pages 7: Mitochondrial Dysfunction in Cancer and Neurodegenerative Diseases: Spotlight on Fatty Acid Oxidation and Lipoperoxidation Products
In several human diseases, such as cancer and neurodegenerative diseases, the levels of reactive oxygen species (ROS), produced mainly by mitochondrial oxidative phosphorylation, is increased. In cancer cells, the increase of ROS production has been associated with mtDNA mutations that, in turn, seem to be functional in the alterations of the bioenergetics and the biosynthetic… Continue reading Antioxidants, Vol. 5, Pages 7: Mitochondrial Dysfunction in Cancer and Neurodegenerative Diseases: Spotlight on Fatty Acid Oxidation and Lipoperoxidation Products
Diagnosing oral squamous cell carcinoma: How much imaging do we really need? A review of the current literature
Complementary imaging techniques that round out the clinical examination are fundamentally important in the work-up of patients with oral squamous cell carcinoma (OSCC). Above all, exact determination of primary tumour extent, metastatic spread, and treatment response highly depend on accurate imaging methods. Despite a multitude of recently published reviews, there is still an ongoing debate… Continue reading Diagnosing oral squamous cell carcinoma: How much imaging do we really need? A review of the current literature
Voice Signals Produced With Jitter Through a Stochastic One-mass Mechanical Model
The quasiperiodic oscillation of the vocal folds causes perturbations in the length of the glottal cycles, which are known as jitter. The observation of the glottal cycles variations suggests that jitter is a random phenomenon described by random deviations of the glottal cycle lengths in relation to a corresponding mean value and, in general, its… Continue reading Voice Signals Produced With Jitter Through a Stochastic One-mass Mechanical Model
IJMS, Vol. 17, Pages 250: Assessment of Radiation Induced Therapeutic Effect and Cytotoxicity in Cancer Patients Based on Transcriptomic Profiling
Toxicity induced by radiation therapy is a curse for cancer patients undergoing treatment. It is imperative to understand and define an ideal condition where the positive effects notably outweigh the negative. We used a microarray meta-analysis approach to measure global gene-expression before and after radiation exposure. Bioinformatic tools were used for pathways, network, gene ontology… Continue reading IJMS, Vol. 17, Pages 250: Assessment of Radiation Induced Therapeutic Effect and Cytotoxicity in Cancer Patients Based on Transcriptomic Profiling
Assessments of Voice Use and Voice Quality Among College/University Singing Students Ages 18–24 Through Ambula tory Monitoring With a Full Accelerometer Signal
The multiple social and performance demands placed on college/university singers could put their still-developing voices at risk. Previous ambulatory monitoring studies have analyzed the duration, intensity, and frequency (in Hertz) of voice use among such students. Nevertheless, no studies to date have incorporated the simultaneous acoustic voice quality measures into the acquisition of these measures… Continue reading Assessments of Voice Use and Voice Quality Among College/University Singing Students Ages 18–24 Through Ambula tory Monitoring With a Full Accelerometer Signal
Sensitive Zn2+ Sensor based on Biofunctionalized Nanopores by Combination of DNAzyme and DNA Supersandwich Structures
Analyst, 2016, Accepted Manuscript DOI: 10.1039/C6AN00171H, Communication nannan liu, Ruizuo Hou, Pengcheng Gao, Xiaoding Lou, fan xia The sensitivity of the detection based on biofunctionalized nanopores is limited since the target-to-signal ratio is 1:1. Isothermal amplification is a promising amplified strategy at constant temperature due to its… The content of this RSS Feed (c) The… Continue reading Sensitive Zn2+ Sensor based on Biofunctionalized Nanopores by Combination of DNAzyme and DNA Supersandwich Structures
Toxins, Vol. 8, Pages 49: Heterologous Expression of Toxins from Bacterial Toxin-Antitoxin Systems in Eukaryotic Cells: Strategies and Applications
Toxin-antitoxin (TA) systems are found in nearly all prokaryotic genomes and usually consist of a pair of co-transcribed genes, one of which encodes a stable toxin and the other, its cognate labile antitoxin. Certain environmental and physiological cues trigger the degradation of the antitoxin, causing activation of the toxin, leading either to the death or… Continue reading Toxins, Vol. 8, Pages 49: Heterologous Expression of Toxins from Bacterial Toxin-Antitoxin Systems in Eukaryotic Cells: Strategies and Applications
IJMS, Vol. 17, Pages 257: Deletion of Phytochelatin Synthase Modulates the Metal Accumulation Pattern of Cadmium Exposed C. elegans
Environmental metal pollution is a growing health risk to flora and fauna. It is therefore important to fully elucidate metal detoxification pathways. Phytochelatin synthase (PCS), an enzyme involved in the biosynthesis of phytochelatins (PCs), plays an important role in cadmium detoxification. The PCS and PCs are however not restricted to plants, but are also present… Continue reading IJMS, Vol. 17, Pages 257: Deletion of Phytochelatin Synthase Modulates the Metal Accumulation Pattern of Cadmium Exposed C. elegans
Variations of mucosal‐sparing septectomy for endonasal approach to the craniocervical junction
ConclusionThese variations/refinements of the mucosal‐sparing approach to the CCJ allowed adequate surgical access with sufficient maneuverability while preserving both PNSFs. Level of EvidenceNA. Laryngoscope, 2015 (Source: The Laryngoscope) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Tu0QCk via IFTTT
Obesity as a risk factor for atrial fibrillation.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
[Obesity as a risk factor for atrial fibrillation]. Pol Merkur Lekarski. 2016 Jan 28;40(235):5-8 Authors: Duraj I, Broncel M Abstract Atrial fibrillation (AF) and obesity is a growing problem of public health both in Poland and in the whole world. AF risk factors may be summarized as elderliness, male sex, smoking, hypertension, diabetes, obesity, coronary […]
In Response.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In Response. Anesth Analg. 2016 Mar;122(3):915-916 Authors: Correa D, Farney RJ, Chung F, Prasad A, Lam D, Wong J PMID: 26891400 [PubMed – as supplied by publisher] from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LwJSf4 via IFTTT
Opioids and Sleep Apnea: More Than Perioperative Impact.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Opioids and Sleep Apnea: More Than Perioperative Impact. Anesth Analg. 2016 Mar;122(3):915 Authors: Fan X, Straube S PMID: 26891399 [PubMed – as supplied by publisher] from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UbRWJg via IFTTT
Melatonin and Sleep-Wake Rhythms before and after Ocular Lens Replacement in Elderly Humans.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Melatonin and Sleep-Wake Rhythms before and after Ocular Lens Replacement in Elderly Humans. Biology (Basel). 2016;5(1) Authors: Giménez M, Beersma D, Daan S, Pol BV, Kanis M, van Norren D, Gordijn M Abstract Light of short wavelengths has been shown to play a key role in non-image forming responses. Due to aging, the ocular lens […]
The borderlands of waking: Quantifying the transition from reflective thought to hallucination in sleep onset.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The borderlands of waking: Quantifying the transition from reflective thought to hallucination in sleep onset. Conscious Cogn. 2016 Feb 15;41:57-63 Authors: Speth C, Speth J Abstract We lose waking consciousness spontaneously and regularly over the circadian cycle. It seems that every time we fall asleep, reflective thinking gradually gives way to our interactions with an […]
Multi-scale finite element modeling of eustachian tube function: influence of mucosal adhesion.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Multi-scale finite element modeling of eustachian tube function: influence of mucosal adhesion. Int J Numer Method Biomed Eng. 2016 Feb 18; Authors: Malik JE, Swarts JD, Ghadiali SN Abstract The inability to open the collapsible Eustachian tube (ET) leads to the development of chronic Otitis Media (OM). Although mucosal inflammation during OM leads to increased […]
Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs Cooperative Study #504.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs Cooperative Study #504. J Clin Psychiatry. 2016 Feb 2; Authors: Krystal JH, Pietrzak RH, Rosenheck RA, Cramer JA, Vessicchio J, Jones KM, Huang GD, Vertrees JE, Collins J, Krystal AD, Veterans Affairs Cooperative Study #504 Group Abstract OBJECTIVE: […]
Spontaneous complete resolutıon of pneumomedıastınum and pneumatosıs ıntestınalıs caused by acute GVHD.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Spontaneous complete resolutıon of pneumomedıastınum and pneumatosıs ıntestınalıs caused by acute GVHD. Am J Hematol. 2016 Feb 18; Authors: Keklik F, Cayci Z, Arndt P, Ustun C PMID: 26890819 [PubMed – as supplied by publisher] from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LwJU6y via IFTTT
Delusions in Patients with Alzheimer’s Disease: A Multidimensional Approach.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Delusions in Patients with Alzheimer’s Disease: A Multidimensional Approach. J Alzheimers Dis. 2016 Feb 5; Authors: D’Onofrio G, Panza F, Sancarlo D, Paris FF, Cascavilla L, Mangiacotti A, Lauriola M, Paroni GH, Seripa D, Greco A Abstract In Alzheimer’s disease (AD) patients with delusions, clinical outcomes and mortality result from a combination of psychological, biological, […]
Mechanisms of microglial activation in models of INFLAMMATION AND hypoxia: implications for chronic intermittent hypoxia.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Mechanisms of microglial activation in models of INFLAMMATION AND hypoxia: implications for chronic intermittent hypoxia. J Physiol. 2016 Feb 18; Authors: Kiernan EA, Smith SM, Mitchell GS, Watters JJ Abstract Chronic intermittent hypoxia (CIH) is a hallmark of sleep apnea, a condition associated with diverse clinical disorders. CIH and sleep apnea are characterized by increased […]
A new technique to improve velopharyngeal dysfunction by combining the radical intravelar veloplasty and overlapping intravelar veloplasty for primary palatoplasty.
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Reply Letter to Editor: Dynamics of Gluteal Cleft Morphology in Lower Body Lift: Predictors of Unfavorable Outcomes.
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Growing Body of Evidence Supports Safety of Female Genital Cosmetic Surgery.
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Comparison of Outcomes for Normal Saline and an Antiseptic Solution for Negative-Pressure Wound Therapy with Instillation.
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Reply to: Commentary on 'Abdominoplasty: risk factors, complication rates, and safety of combined procedures'.
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Reply to letter: Response to "Fibrous Dysplasia: Management of the Optic Canal".
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Local 'free-style' perforator flaps in head and neck reconstruction: an update and a useful classification.
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AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High Fat Diet
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Effect of n-3 and n-6 Polyunsaturated Fatty Acids on Microsomal P450 Steroidogenic Enzyme Activities and In Vitro Cortisol Production in Adrenal Tissue from Male Yorkshire Boars
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Reduced sensitivity to context in language comprehension: A characteristic of Autism Spectrum Disorders or of poor structural language ability?
Publication date: Available online 18 February 2016 *Source:*Research in Developmental Disabilities Author(s): Melanie Eberhardt, Aparna Nadig We present two experiments examining the universality and uniqueness of reduced context sensitivity in language processing in Autism Spectrum Disorders (ASD), as proposed by the Weak Central Coherence account (Happé & Frith, 2006, Journal of Autism and Developmental Disorders, 36(1), 25). That is, do all children with ASD exhibit decreased context sensitivity, and is this characteristic specific to ASD versus other neurodevelopmental conditio... περισσότερα »
Exercise-induced oxidative stress: past, present and future
Abstract The existence of free radicals in living cells was first reported in 1954 and this important finding helped launch the field of free radical biology. However, the discovery that muscular exercise is associated with increased biomarkers of oxidative stress did not occur until 1978. Following the initial report that exercise promotes oxidative stress in humans, many studies have confirmed that prolonged or short-duration high intensity exercise results in increased radical production in active skeletal muscles resulting in the formation of oxidized lipids and proteins in th... περισσότερα »
Researchers Make Progress in Genomic Classification of Bladder Cancers
Investigators from seven centers of excellence from around the world met at the Spanish National Cancer Research Centre-CNIO (Madrid, Spain) in 2015. Each group, having proposed a genome-based molecular taxonomy of urothelial bladder cancer (UBC), recognized the value of an agreement that could then help facilitate progress in the field and stimulate collaboration. Lead author of the consensus document Seth P. Lerner, MD, Editor-in-Chief of *Bladder Cancer*, and Professor of Urology, Scott Department of Urology, Baylor College of Medicine, Houston, explained, "The need to reach co... περισσότερα »
Hyperocclusion stimulates the expression of collagen type XII in periodontal ligament
Publication date: Available online 18 February 2016 *Source:*Archives of Oral Biology Author(s): Takashi Tsuzuki, Hiroshi Kajiya, Kazuko T-Goto, Takashi Tsutsumi, Tetsuomi Nemoto, Koji Okabe, Yutaka Takahashi ObjectivesIt is known that excessive mechanical force exerted by hyperocclusion induces occlusal trauma. However, the mechanism of the process remains unclear. In the present study, we employed an in vivo hyperocclusion rodent model to examine morphological and biological mechanisms of occlusal trauma in periodontal ligament tissue.DesignTo investigate alveolar bone resorption,...περισσότερα »
Comparison of Consanguinity between Parents of Hearing Impaired and Public School Children with Estimation of Risk.
Related Articles *Comparison of Consanguinity between Parents of Hearing Impaired and Public School Children with Estimation of Risk.* Mymensingh Med J. 2015 Oct;24(4):743-9 Authors: Sattar MA, Sultana MT Abstract Deafness is the hidden disability and the most common human sensory defects which lead to poor educational and employment prospects of childhood. Is there any association of consanguinity and hearing loss or are there any difference of association of consanguinity and hearing loss in specialized and public school children and how much risk is associated?--were the rese...περισσότερα »
Auditory neuropathy spectrum disorder with Brown-Vialetto-Van Laere syndrome: challenges in hearing rehabilitation.
Related Articles *Auditory neuropathy spectrum disorder with Brown-Vialetto-Van Laere syndrome: challenges in hearing rehabilitation.* J Laryngol Otol. 2015 May;129(5):504-8 Authors: Chandran R, Alexander M, Naina P, Balraj A Abstract BACKGROUND: Brown-Vialetto-Van Laere syndrome is a rare neurological disorder characterised by pontobulbar palsy and sensorineural hearing loss. Hearing rehabilitation continues to be a challenge because the exact lesion site is unknown. CASE REPORT: We examined the clinical and audiological profiles of a case series comprising four siblings with Br...περισσότερα »
Is non-invasive neuromuscular electrical stimulation effective in severe chronic neurogenic dysphagia? Reporton a post-traumatic brain injury patient.
*Is non-invasive neuromuscular electrical stimulation effective in severe chronic neurogenic dysphagia? Reporton a post-traumatic brain injury patient.* NeuroRehabilitation. 2016 Feb 10;38(1):53-57 Authors: Calabrò RS, Nibali VC, Naro A, Floridia D, Pizzimenti M, Salmeri L, Salviera C, Bramanti P Abstract BACKGROUND: Neurogenic dysphagia is a difficulty in swallowing induced by nervous system disease. It often causes serious complications, which are preventable if dysphagia is properly managed. There is growing debate concerning the usefulness of non-invasive neuromuscular electr... περισσότερα »
Physiology Of Drowning: A Review.
*Physiology Of Drowning: A Review.* Physiology (Bethesda). 2016 Mar;31(2):147-66 Authors: Bierens JJ, Lunetta P, Tipton M, Warner DS Abstract Drowning physiology relates to two different events: immersion (upper airway above water) and submersion (upper airway under water). Immersion involves integrated cardiorespiratory responses to skin and deep body temperature, including cold shock, physical incapacitation, and hypovolemia, as precursors of collapse and submersion. The physiology of submersion includes fear of drowning, diving response, autonomic conflict, upper airway reflex...περισσότερα »
Intestinal microbiome disruption in patients in a long-term acute care hospital: A case for development of microbiome disruption indices to improve infection prevention
Publication date: Available online 19 February 2016 *Source:*American Journal of Infection Control Author(s): Alison Laufer Halpin, Tom J.B. de Man, Colleen S. Kraft, K. Allison Perry, Austin W. Chan, Sung Lieu, Jeffrey Mikell, Brandi M. Limbago, L. Clifford McDonald BackgroundComposition and diversity of intestinal microbial communities (microbiota) are generally accepted as a risk factor for poor outcomes; however, we cannot yet use this information to prevent adverse outcomes.MethodsStool was collected from 8 long-term acute care hospital patients experiencing diarrhea and 2 feca...περισσότερα »
Simulation education as a single intervention does not improve hand hygiene practices: A randomized controlled follow-up study
Publication date: Available online 18 February 2016 *Source:*American Journal of Infection Control Author(s): Miia M. Jansson, Hannu P. Syrjälä, Pasi P. Ohtonen, Merja H. Meriläinen, Helvi A. Kyngäs, Tero I. Ala-Kokko BackgroundTo evaluate how critical nurses' knowledge of and adherence to current care hand hygiene (HH) guidelines differ between randomly allocated intervention and control groups before and after simulation education in both a simulation setting and clinical practice during a 2-year follow-up period. It was hypothesized that intervention group knowledge of and adhere...περισσότερα »
Evaluating the impact of an antimicrobial stewardship program on the length of stay of immune-competent adult patients admitted to a hospital ward with a diagnosis of community-acquired pneumonia: A quasi-experimental study
Publication date: Available online 18 February 2016 *Source:*American Journal of Infection Control Author(s): Giulio DiDiodato, Leslie McArthur, Joseph Beyene, Marek Smieja, Lehana Thabane BackgroundThe purpose of this study was to demonstrate an antimicrobial stewardship intervention can reduce length of stay for patients admitted to hospital with community-acquired pneumonia (CAP).MethodsStarting April 1, 2013, consecutive adult patients with CAP admitted to an acute care community hospital in Barrie, Ontario, Canada, were eligible for enrollment until March 31, 2015. The antimicr...περισσότερα »
Performance characteristics and associated outcomes for an automated surveillance tool for bloodstream infection
Publication date: Available online 18 February 2016 *Source:*American Journal of Infection Control Author(s): Jessica P. Ridgway, Xiaowu Sun, Ying P. Tabak, Richard S. Johannes, Ari Robicsek BackgroundThe objective of this study was to evaluate performance metrics and associated patient outcomes of an automated surveillance system, the blood Nosocomial Infection Marker (NIM).MethodsWe reviewed records of 237 patients with and 36,927 patients without blood NIM using the National Healthcare Safety Network (NHSN) definition for laboratory-confirmed bloodstream infection (BSI) as the go...περισσότερα »
