The Temperature-Dependent Impact of Thermal-ALA-PDT on Apoptosis and Reactive Oxygen Species Generation in Human Dermal Fibroblasts
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
Abstract Background Actinic keratoses (AKs) are generally accepted as common precursor lesions to invasive squamous cell carcinoma (SCC). Photodynamic Therapy (PDT) is a common, in office, field therapy modality used in the treatment of AKs. Clinical and laboratory observations have demonstrated that temperature modulation can impact PDT efficacy. Objective To demonstrate thermal PDT increases apoptotic cell death and to investigate the mechanistic role of reactive oxygen species (ROS) free radicals in an in vitro human skin fibroblast model. Methods This study was completed us...περισσότερα »
Protein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cell carcinoma
Protein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cell carcinoma: The purpose of this study was to evaluate the expression of the enzymes involved in the biotransformation of tobacco and alcohol. A study group of 41 young patients (≤40 years old) with oral squamous cell carcinoma (OSCC) was compared to 59 control subjects (≥50 years old) with tumours of similar clinical stages and topographies. The immunohistochemical expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 was evaluated using the tissue microarray technique. There was a predomina... περισσότερα »
Helicobacter pylori in children with asthmatic conditions at school age, and their mothers
Helicobacter pylori in children with asthmatic conditions at school age, and their mothers: Summary Background *Helicobacter pylori* prevalence in Western countries has been declining simultaneously with increases in childhood asthma and allergic diseases; prior studies have linked these phenomena. Aims To examine the association between *H. pylori* colonisation in children and risk of asthma and related conditions at school age. We secondly examined additional effects of maternal *H. pylori* status by pairing with children's status. Methods This study was embedded in a multi-ethnic...περισσότερα »
Computer-aided design–computer-aided manufacturing (CAD-CAM) Blocks
From Artisanal to CAD-CAM Blocks: State of the Art of Indirect Composites: Indirect composites have been undergoing an impressive evolution over the last few years. Specifically, recent developments in computer-aided design–computer-aided manufacturing (CAD-CAM) blocks have been associated with new polymerization modes, innovative microstructures, and different compositions. All these recent breakthroughs have introduced important gaps among the properties of the different materials. This critical state-of-the-art review analyzes the strengths and weaknesses of the different variet... περισσότερα »
Mast Cells Contribute to Porphyromonas gingivalis-induced Bone Loss
Mast Cells Contribute to Porphyromonas gingivalis-induced Bone Loss: Periodontitis is a chronic inflammatory and bone-destructive disease. Development of periodontitis is associated with dysbiosis of the microbial community, which may be caused by periodontal bacteria, such as *Porphyromonas gingivalis*. Mast cells are sentinels at mucosal surfaces and are a potent source of inflammatory mediators, including tumor necrosis factors (TNF), although their role in the pathogenesis of periodontitis remains to be elucidated. This study sought to determine the contribution of mast cells t... περισσότερα »
Interleukin-17 Impairs Salivary Tight Junction Integrity in Sjögrens Syndrome
Interleukin-17 Impairs Salivary Tight Junction Integrity in Sjögrens Syndrome: Sjögren’s syndrome (SS) is an inflammatory autoimmune disease that causes secretory dysfunction of the salivary glands. It has been reported that proinflammatory cytokine interleukin-17 (IL-17) was elevated and tight junction (TJ) integrity disrupted in minor salivary glands from SS patients. However, whether the elevated IL-17 in SS affects TJ integrity and thereby alters the function of salivary gland is unknown. Here, by using nonobese diabetic (NOD) mice as SS model, we found that the stimulated s... περισσότερα »
Somatic Symptoms: Prevalence, Co-Occurrence and Associations with Self-Perceived Health and Limitations Due To Physical Health – A Danish Population-Based Study
Somatic Symptoms: Prevalence, Co-Occurrence and Associations with Self-Perceived Health and Limitations Due To Physical Health – A Danish Population-Based Study: by Marie Eliasen, Svend Kreiner, Jeanette F. Ebstrup, Chalotte H. Poulsen, Cathrine J. Lau, Sine Skovbjerg, Per K. Fink, Torben Jørgensen A high number of somatic symptoms have been associated with poor health status and increased health care use. Previous studies focused on number of symptoms without considering the specific symptoms. The aim of the study was to investigate 1) the prevalence of 19 somatic symptoms, 2) the... περισσότερα »
Alternating Polarity and Forward Masking Artifact-Reduction Methods to Resolve the Electrically Evoked Compound Action Potential.
A Comparison of Alternating Polarity and Forward Masking Artifact-Reduction Methods to Resolve the Electrically Evoked Compound Action Potential.: Abstract Objective: Cochlear implant manufacturers utilize different artifact-reduction methods to measure electrically evoked compound action potentials (ECAPs) in the clinical software. Two commercially available artifact-reduction techniques include forward masking (FwdMsk) and alternating polarity (AltPol). AltPol assumes that responses to the opposing polarities are equal, which is likely problematic. On the other hand, FwdMsk ca... περισσότερα »
Intelligibility of the Patient's Speech Predicts the Likelihood of Cochlear Implant Success in Prelingually Deaf Adults.
Intelligibility of the Patient's Speech Predicts the Likelihood of Cochlear Implant Success in Prelingually Deaf Adults.: Objectives: The objective of this study was to determine the validity and clinical applicability of intelligibility of the patient's own speech, measured via a Vowel Identification Test (VOW), as a predictor of speech perception for prelingually deafened adults after 1 year of cochlear implant use. Specifically, the objective was to investigate the probability that a prelingually deaf patient, given a VOW score above (or below) a chosen cutoff point, reaches a po... περισσότερα »
Effects of Modified Hearing Aid Fittings on Loudness and Tone Quality for Different Acoustic Scenes.
Effects of Modified Hearing Aid Fittings on Loudness and Tone Quality for Different Acoustic Scenes.: Objective: To compare loudness and tone-quality ratings for sounds processed via a simulated five-channel compression hearing aid fitted using NAL-NL2 or using a modification of the fitting designed to be appropriate for the type of listening situation: speech in quiet, speech in noise, music, and noise alone. Design: Ratings of loudness and tone quality were obtained for stimuli presented via a loudspeaker in front of the participant. For normal-hearing participants, levels of 50, ... περισσότερα »
Neural Correlates of Phonetic Learning in Postlingually Deafened Cochlear Implant Listeners.
Neural Correlates of Phonetic Learning in Postlingually Deafened Cochlear Implant Listeners.: Objective: The present training study aimed to examine the fine-scale behavioral and neural correlates of phonetic learning in adult postlingually deafened cochlear implant (CI) listeners. The study investigated whether high variability identification training improved phonetic categorization of the /ba/-/da/ and /wa/-/ja/ speech contrasts and whether any training-related improvements in phonetic perception were correlated with neural markers associated with phonetic learning. It was hypoth... περισσότερα »
The Spatial Hearing Questionnaire and Its Short Form
Validation of the Chinese Translation of the Spatial Hearing Questionnaire and Its Short Form: Purpose Few questionnaires address how to measure spatial hearing ability in complex listening situations. The purpose of the study was (a) to validate the Chinese translation of the Spatial Hearing Questionnaire (C-SHQ) among Chinese participants and (b) to provide a shortened version for the purpose of clinical screening. Method This was a cross-sectional study. The C-SHQ was developed from the process of translation and back-translation of the original 24-item, English version (Tyler... περισσότερα »
Edible Plant Exosome Ability to Prevent Oral Mucositis Associated With Chemoradiation Treatment of Head and Neck Cancer
Edible Plant Exosome Ability to Prevent Oral Mucositis Associated With Chemoradiation Treatment of Head and Neck Cancer: *Conditions*: Head and Neck Cancer; Oral Mucositis *Interventions*: Dietary Supplement: Grape extract; Drug: Lortab, Fentanyl patch, mouthwash *Sponsors*: James Graham Brown Cancer Center; University of Louisville ArmsAssigned Interventions Experimental: 1 - Grape extract Grape extract self-administered daily by mouth for 35 days during chemoradiation therapy. Dietary Supplement: Grape extract Grape extract self-administered by mouth daily for 35 days... περισσότερα »
Skin Rash Study Before Chemotherapy in Colorectal & Head and Neck Cancer Patients
Skin Rash Study Before Chemotherapy in Colorectal & Head and Neck Cancer Patients: *Conditions*: Colorectal Cancer; Head and Neck Cancer *Interventions*: Drug: Doxycycline; Drug: Hydrocortisone 1% cream; Other: Sunscreen; Other: Moisturizer; Drug: Clindamycin; Drug: Medrol-dose pack (Steroid) *Sponsors*: James Graham Brown Cancer Center; University of Louisville The purpose of this study is to determine if using preventive treatments such as Doxycycline (an anti-biotic) capsules, sunscreen with SPF 30, Hydrocortisone 1% cream and a moisturizer will help to redu... περισσότερα »
Assessing the Electrode-Neuron Interface with the Electrically Evoked Compound Action Potential, Electrode Position, and Behavioral Thresholds
Assessing the Electrode-Neuron Interface with the Electrically Evoked Compound Action Potential, Electrode Position, and Behavioral Thresholds: AbstractVariability in speech perception scores among cochlear implant listeners may largely reflect the variable efficacy of implant electrodes to convey stimulus information to the auditory nerve. In the present study, three metrics were applied to assess the quality of the electrode-neuron interface of individual cochlear implant channels: the electrically evoked compound action potential (ECAP), the estimation of electrode position usin... περισσότερα »
Elevated Acoustic Startle Responses in Humans: Relationship to Reduced Loudness Discomfort Level, but not Self-Report of Hyperacusis
Elevated Acoustic Startle Responses in Humans: Relationship to Reduced Loudness Discomfort Level, but not Self-Report of Hyperacusis: AbstractIncreases in the acoustic startle response (ASR) of animals have been reported following experimental manipulations to induce tinnitus, an auditory disorder defined by phantom perception of sound. The increases in ASR have been proposed to signify the development of hyperacusis, a clinical condition defined by intolerance of normally tolerable sound levels. To test this proposal, the present study compared ASR amplitude to measures of sound-l...περισσότερα »
Diagnosis of HIV-Associated Oral Lesions in Relation to Early versus Delayed Antiretroviral Therapy: Results from the CIPRA HT001 Trial
Diagnosis of HIV-Associated Oral Lesions in Relation to Early versus Delayed Antiretroviral Therapy: Results from the CIPRA HT001 Trial: by Ashita S. Batavia, Rode Secours, Patrice Espinosa, Marc Antoine Jean Juste, Patrice Severe, Jean William Pape, Daniel W. Fitzgerald Oral mucosal lesions that are associated with HIV infection can play an important role in guiding the decision to initiate antiretroviral therapy (ART). The incidence of these lesions relative to the timing of ART initiation has not been well characterized. A randomized controlled clinical trial was conducted at th... περισσότερα »
Atrial Fibrillation in Patients with Acute Pulmonary Embolism
The Prevalence and Incidence of Atrial Fibrillation in Patients with Acute Pulmonary Embolism: by Austin Chin Chwan Ng, Dona Adikari, David Yuan, Jerrett K. Lau, Andy Sze Chiang Yong, Vincent Chow, Leonard Kritharides Background Symptomatic pulmonary embolism (PE) is a major cause of cardiovascular death and morbidity. Estimated prevalence and incidence of atrial fibrillation (AF) in developed countries are between 388–661 per 100,000, and 90–123 per 100,000 person-years respectively. However, the prevalence and incidence of AF in patients presenting with an acute PE and its pre...περισσότερα »
Packing Material in Middle Ear Trauma
Comparison of Packing Material in an Animal Model of Middle Ear Trauma: [image: gr1.sml] To compare the performance of absorbable gelatin sponge (AGS) with polyurethane foam (PUF) as middle ear packing material after mucosal trauma.
Socioeconomic and Other Demographic Disparities Predicting Survival among Head and Neck Cancer Patients
Socioeconomic and Other Demographic Disparities Predicting Survival among Head and Neck Cancer Patients: by Seung Hee Choi, Jeffrey E. Terrell, Karen E. Fowler, Scott A. McLean, Tamer Ghanem, Gregory T. Wolf, Carol R. Bradford, Jeremy Taylor, Sonia A. Duffy Background The Institute of Medicine (IOM) report, “Unequal Treatment,” which defines disparities as racially based, indicates that disparities in cancer diagnosis and treatment are less clear. While a number of studies have acknowledged cancer disparities, they have limitations of retrospective nature, small sample sizes, in... περισσότερα »
Management and Outcomes of Pediatric Descending Mediastinitis
Retrospective Review of Management and Outcomes of Pediatric Descending Mediastinitis: Objectives To review the management and outcomes of pediatric patients treated for descending mediastinitis at a single institution and contribute to an updated mortality rate. Study Design Case series with chart review. Setting Tertiary care pediatric hospital. Subjects and Methods This study is a 19-patient case series of all patients treated for descending mediastinitis at a tertiary pediatric hospital from 1997 to 2015, and it serves as an update to the case series published from this ins... περισσότερα »
Reoperation following Adult Tonsillectomy: Review of the American College of Surgeons National Surgical Quality Improvement Program
Reoperation following Adult Tonsillectomy: Review of the American College of Surgeons National Surgical Quality Improvement Program: Objective Tonsillectomy remains a common procedure in adults; however, there are few population-level data evaluating risk factors for reoperation. Study Design Retrospective review of national database. Setting American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP), 2005-2013. Subjects and Methods The ACS-NSQIP was queried for patients undergoing tonsillectomy ± adenoidectomy as their primary procedure (*CPT* 42821 o... περισσότερα »
Ciprofloxacin Decreases Collagen in Mouse Tympanic Membrane Fibroblasts
Ciprofloxacin Decreases Collagen in Mouse Tympanic Membrane Fibroblasts: Objectives To determine how collagen production by tympanic membrane fibroblasts is affected by ciprofloxacin at levels found in eardrops. Study Design Prospective, controlled, and blinded cell culture study. Setting Academic tertiary medical center. Subjects Cell culture of mouse fibroblasts. Methods A primary fibroblast culture was established from mouse tympanic membranes. Fibroblasts were cultured until they were 75% confluent, then treated with dilute hydrochloric acid (control) or ciprofloxacin (0.01...περισσότερα »
Sinus Computed Tomography Imaging in Pediatric Cystic Fibrosis: Added Value?
Sinus Computed Tomography Imaging in Pediatric Cystic Fibrosis: Added Value?: Study Objective To evaluate the prevalence of computed tomography (CT) sinus imaging in a pediatric cystic fibrosis (CF) population, determine changes in Lund Mackay (LM) scores over time, and estimate radiation exposure. Study Design Case series with chart review. Setting Tertiary care children’s hospital. Subjects and Methods In total, 202 pediatric patients with CF who underwent endoscopic sinus surgery (ESS) were included. The total number of CT scans was calculated for each patient, with specific ...περισσότερα »
Effects of a Fibrin Sealant on Skin Graft Tissue Adhesion in a Rodent Model
Effects of a Fibrin Sealant on Skin Graft Tissue Adhesion in a Rodent Model: Objective To establish a rodent model for skin grafting with fibrin glue and examine the effects of fibrin glue on the adhesive strength of skin grafts without bolsters. Study Design Animal cohort. Setting Academic hospital laboratory. Subjects and Methods Three skin grafts were created using a pneumatic microtome on the dorsum of 12 rats. Rats were evenly divided into experimental (n = 6) and control (n = 6) groups. The experimental group received a thin layer of fibrin glue between the graft and woun... περισσότερα »
Pediatric Endoscopic Cholesteatoma Surgery
Pediatric Endoscopic Cholesteatoma Surgery: Objectives (1) To describe and review a single center’s pediatric endoscopic cholesteatoma experience, including surgical and audiologic outcomes. (2) To assess the most common locations of residual cholesteatoma following endoscopic removal. Study Design Case series with chart review. Setting Tertiary otologic referral center. Subjects Patients <19 years of age who underwent cholesteatoma removal with either endoscopic or microscopic visualization. Methods In a comparison of patients who underwent total endoscopic ear surgery (TEES)...περισσότερα »
Oral Antibiotic Use for Otitis Media with Effusion: Ongoing Opportunities for Quality Improvement
Oral Antibiotic Use for Otitis Media with Effusion: Ongoing Opportunities for Quality Improvement: Objectives (1) To evaluate the probability of antibiotic administration associated with *ICD-9* diagnosis of otitis media with effusion (OME) in the absence of acute otitis media, (2) to determine whether usage varies according to visit setting, and (3) to ascertain if practice gaps are such that future practice changes might be measured. Study Design Cross-sectional analysis of an administrative database. Setting Ambulatory visits in the United States. Subjects and Methods Nationa... περισσότερα »
Trends in the Incidence of Oropharyngeal Cancers in the United States
Trends in the Incidence of Oropharyngeal Cancers in the United States: Objective The incidence of oropharyngeal squamous cell carcinoma (SCCa) has increased in the United States despite a decrease in tobacco usage, and it may be driven by an increase in oral human papilloma virus (HPV) infection. We studied the incidence of tongue base and tonsillar SCCa over time to understand the changing epidemiology of oropharyngeal SCCa. Setting Large national tumor registry. Subjects and Methods We studied patients diagnosed with oropharyngeal SCCa in SEER data (Surveillance, Epidemiology, ...περισσότερα »
Quantitative Proteomics of Vestibular Schwannoma Cerebrospinal Fluid: A Pilot Study
Quantitative Proteomics of Vestibular Schwannoma Cerebrospinal Fluid: A Pilot Study: This pilot study aimed to identify candidate proteins for future study that are differentially expressed in vestibular schwannoma (VS) cerebrospinal fluid (CSF) and to compare such proteins with those previously identified in perilymph and specimen secretions. CSF was collected intraoperatively prior to removal of untreated sporadic VS (3 translabyrinthine, 3 middle cranial fossa approaches) and compared with reference CSF samples. After proteolytic digestion and iTRAQ labeling, tandem mass spectro...περισσότερα »
Audiometric Testing in the Pediatric Population
A Charge Comparison of Audiometric Testing in the Pediatric Population: Objective To determine the charges associated with performing combined tympanometry and otoacoustic emissions vs a comprehensive audiogram in the pediatric population and to analyze its implications for future practice. Study Design Retrospective charge analysis. Setting Tertiary care academic center. Subjects and Methods Analysis was performed on 538 pediatric patients who underwent audiometric hearing testing from May through October 2014. Results In total, 401 patients had combined tympanometry and otoac...περισσότερα »
Associations of Volume and Thyroidectomy Outcomes
Associations of Volume and Thyroidectomy Outcomes: A Nationwide Study with Systematic Review and Meta-Analysis: Objective This study explored how different hospital volumes and surgeon volumes affect thyroidectomy outcomes in terms of length of stay (LOS), costs, and in-hospital mortality. Data Sources MEDLINE and EMBASE databases. Review Methods This study retrospectively analyzed a cohort of 125,037 thyroidectomy patients treated at Taiwan hospitals from 1996 to 2010. Relationships between hospital/surgeon volume and patient outcomes were retrospectively analyzed by propensity ...περισσότερα »
Titanium Ossiculoplasty in Chronic Otitis Media
Long-Term Outcomes of Titanium Ossiculoplasty in Chronic Otitis Media: Objective The primary objective is to report long-term hearing outcomes (>2 years) after titanium ossiculoplasty in patients with chronic otitis media. Study Design Case series with chart review. Setting Tertiary care hospital. Subjects and Methods In total, 156 patients with chronic otitis media undergoing titanium ossiculoplasty were included. The primary outcome measure was the long-term postoperative ABG. The stability of hearing over time was determined by comparing short-term and long-term postoperative... περισσότερα »
Monothermal Caloric Screening Test Accuracy: A Systematic Review
Monothermal Caloric Screening Test Accuracy: A Systematic Review: Objective To minimize discomfort, time, and costs, vestibular laboratories may perform monothermal caloric irrigations and discontinue testing if responses are symmetric. This systematic review aimed to determine the diagnostic accuracy of the monothermal caloric screening test (MCST) for unilateral vestibular dysfunction compared with bithermal caloric testing (BCT). Data Sources Ovid-MEDLINE, EMBASE, Scopus, Cochrane CENTRAL, and manual bibliographic searches. Review Methods Inclusion criteria specified concurren...περισσότερα »
Postoperative Calcium Management in Same-Day Discharge Thyroid and Parathyroid Surgery
Postoperative Calcium Management in Same-Day Discharge Thyroid and Parathyroid Surgery: Objective To describe a safe and effective postoperative prophylactic calcium regimen for same-day discharge thyroid and parathyroid surgery. Study Design Case series with chart review. Setting Tertiary referral academic institution. Subjects and Methods In total, 162 adult patients who underwent total thyroidectomy, completion thyroidectomy, unilateral parathyroidectomy, parathyroidectomy with bilateral neck exploration, or revision parathyroidectomy were identified preoperatively to be cand... περισσότερα »
"Rounded Insertion": A Useful Cochlear Implantation Technique for Patients with Cochlear Hypoplasia Type I
"Rounded Insertion": A Useful Cochlear Implantation Technique for Patients with Cochlear Hypoplasia Type I:
Inhibition of Inflammation-Associated Olfactory Loss by Etanercept in an Inducible Olfactory Inflammation Mouse Model
Inhibition of Inflammation-Associated Olfactory Loss by Etanercept in an Inducible Olfactory Inflammation Mouse Model: Objective To determine the effect of a soluble human tumor necrosis factor alpha (TNF-α) receptor blocker (etanercept) on an inducible olfactory inflammation (IOI) mouse model. Study Design An in vivo study using a transgenic mouse model. Setting Research laboratory. Subjects and Methods To study the impact of chronic inflammation on the olfactory system, a transgenic mouse model of chronic rhinosinusitis–associated olfactory loss was utilized (IOI mouse), expre... περισσότερα »
Endoscopic Radiofrequency Ablation-Assisted Resection of Juvenile Nasopharyngeal Angiofibroma: Comparison with Traditional Endoscopic Technique
Endoscopic Radiofrequency Ablation-Assisted Resection of Juvenile Nasopharyngeal Angiofibroma: Comparison with Traditional Endoscopic Technique: Objectives To evaluate the feasibility of radiofrequency surgical instrumentation for endoscopic resection of juvenile nasopharyngeal angiofibroma (JNA) and to test the hypothesis that endoscopic radiofrequency ablation–assisted (RFA) resection will have superior intraoperative and/or postoperative outcomes as compared with traditional endoscopic (TE) resection techniques. Study Design Case series with chart review. Setting Two tertiary ... περισσότερα »
Diuretics in the Medical Management of Menieres Disease
A Systematic Review of Diuretics in the Medical Management of Menieres Disease: Objective (1) Review evidence for the use of oral diuretic medications in the management of Ménière’s disease. (2) Analyze therapy-related hearing and vertigo outcomes. Data Sources Literature was obtained through directed searches of MEDLINE, EMBASE, Web of Science, EBSCO Host, Cochrane Reviews, and linked citations through seminal papers. We searched independent electronic databases for articles that reported the use of diuretics in patients with Ménière’s disease. Review Methods All articles of lev... περισσότερα »
Orbital Decompression in the Endoscopic Age: The Modified Inferomedial Orbital Strut
Orbital Decompression in the Endoscopic Age: The Modified Inferomedial Orbital Strut: Objective Postoperative diplopia occurs in up to 45% of patients following orbital decompression for exophthalmos associated with Graves’ orbitopathy. We sought to describe outcomes of our balanced orbital decompression strategy that includes the preservation of a modified inferomedial orbital strut (mIOS). Study Design Case series with chart review. Setting Academic medical center. Subjects and Methods A total of 115 consecutive orbital decompressions were performed on 73 patients (42 bilater... περισσότερα »
Nonvisualization of Sialoliths during Sialendoscopy
Nonvisualization of Sialoliths during Sialendoscopy: Objectives Analyze the characteristics of patients undergoing interventional sialendoscopy for sialolithiasis whose stones were not visualized intraoperatively. Study Design Case series with chart review. Setting Tertiary care hospital. Subjects and Methods Patients (n = 276) undergoing sialendoscopy between June 2008 and December 2014 were reviewed for patient characteristics, imaging characteristics, and outcomes. Nonvisualization was defined as a sialolith that was documented on imaging preoperatively but not visualized int...περισσότερα »
Modeled Analysis of Entrance of Colloid Suspensions into the Middle Ear Cavity
Modeled Analysis of Entrance of Colloid Suspensions into the Middle Ear Cavity: Otic suspensions have a positive effect on the duration of otorrhea in children with a tympanostomy tube. It is still questionable how eardrops reach the middle ear. We hypothesized that otic suspensions do not pass the tympanostomy tube if the middle ear is dry but pass by diffusion when wet. The median concentration of Evans blue (colorant) in the middle ear was <15.6 mg/mL (lower limit of quantification) when diffusion was impossible but 45.3 µg/mL when diffusion was possible (*P* = .01). When the ou... περισσότερα »
Endoscopic Transcanal Retrocochlear Approach to the Internal Auditory Canal with Cochlear Preservation: Pilot Cadaveric Study
Endoscopic Transcanal Retrocochlear Approach to the Internal Auditory Canal with Cochlear Preservation: Pilot Cadaveric Study: Contemporary operative approaches to the internal auditory canal (IAC) require the creation of large surgical portals for visualization with associated morbidity, including hearing loss, vestibular dysfunction, facial nerve injury, and skull base defects that increase the risk of cerebrospinal fluid leak. Transcanal approaches to the IAC have been possible only via a transcochlear technique. To preserve cochlear function, we describe a novel endoscopic tran... περισσότερα »
Wire-Bristle Grill Brush Injury
Epidemiology of Wire-Bristle Grill Brush Injury in the United States, 2002-2014: Objectives The purpose of this study was to investigate the epidemiology of wire-bristle grill brush injury. Study Design and Setting Cross-sectional analysis of national databases; literature review. Subjects and Methods The Consumer Product Safety Commission’s National Electronic Injury Surveillance System (NEISS) was used to derive a national weighted estimate of emergency department visits for wire bristle injury from 2002 to 2014. Date, location of injury, demographics, and outcomes were analyzed... περισσότερα »
Biofilms Role in Chronic Cholesteatomatous Otitis Media: A Pilot Study
Biofilms Role in Chronic Cholesteatomatous Otitis Media: A Pilot Study: Cholesteatoma is a destructive lesion involving the temporal bone, which may induce severe complications due to its expansion and erosion of adjacent structures. Bacterial biofilm plays a crucial role in the pathogenesis of many otolaryngologic inflammatory/infectious chronic diseases. In this pilot study, we investigated, by means of cultural examination and with scanning electron microscope, the presence of bacterial biofilm in a series of samples from the epitympanic and mastoid region in patients affected b... περισσότερα »
Acute Rhinosinusitis: Prescription Patterns in a Real-World Setting
Acute Rhinosinusitis: Prescription Patterns in a Real-World Setting: Objective Understand real-world prescription patterns for patients presenting with a first diagnosis of ARS and evaluate adherence to published medical guidelines. Study Design Retrospective administrative database analysis. Setting US-based outpatient settings. Methods From a US claims database (MarketScan), 99,033 patients were identified with acute rhinosinusitis (ARS) in 2012 ("index"), with a complete medical and prescription history for 12 months preindex and 18 months postindex and no diagnoses of asthm... περισσότερα »
Parathyroid 4D CT and Scintigraphy: What Factors Contribute to Missed Parathyroid Lesions?
Parathyroid 4D CT and Scintigraphy: What Factors Contribute to Missed Parathyroid Lesions?: Objective To determine the prevalence of missed lesions for parathyroid 4-dimensional computed tomography (4D CT) and scintigraphy and to describe the factors leading to missed lesions for both modalities. Study Design Case series with chart review. Setting Single center, hospital based. Subjects and Methods Forty patients undergoing 4D CT and scintigraphy before parathyroidectomy between July 2009 and October 2013 were included. Radiology reports and imaging were reviewed and correlated ... περισσότερα »
Transoral Robotic Surgery for Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis
Transoral Robotic Surgery for Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis: Objective To perform a systematic review of the international biomedical literature evaluating the effectiveness, complications, and safety of transoral robotic surgery (TORS) for the treatment of obstructive sleep apnea (OSA). Data Sources PubMed/MEDLINE, Embase, and EMB Reviews databases were searched up to November 27, 2015. Review Methods Two authors systematically and independently searched for articles on TORS for the treatment of OSA in adults that reported either outcomes for the ... περισσότερα »
Injection Laryngoplasty Using Micronized Acellular Dermis for Vocal Fold Paralysis: Long-term Voice Outcomes
Injection Laryngoplasty Using Micronized Acellular Dermis for Vocal Fold Paralysis: Long-term Voice Outcomes: Objectives Micronized acellular dermis has been used for nearly 15 years to correct glottic insufficiency. With previous demonstration of safety and efficacy, this study aims to evaluate intermediate and long-term voice outcomes in those who underwent injection laryngoplasty for unilateral vocal fold paralysis. Technique and timing of injection were also reviewed to assess their impact on outcomes. Study Design Case series with chart review. Setting Tertiary care center. ... περισσότερα »
Cholesterol Granuloma Development following Temporal Bone Surgery
Cholesterol Granuloma Development following Temporal Bone Surgery: Objective To describe the clinical presentation and management of patients with cholesterol granulomas (CGs) that develop following temporal bone surgery. Study Design Case series with chart review. Setting Two independent tertiary academic referral centers. Subjects and Methods A multicenter retrospective review was performed to identify all patients between 2001 and 2014 who were diagnosed with a CG that developed following temporal bone surgery. Patients with a history of idiopathic petrous apex CGs were exclud...περισσότερα »
Lean Belt Certification: Pathway for Student, Resident, and Faculty Development and Scholarship
Lean Belt Certification: Pathway for Student, Resident, and Faculty Development and Scholarship: Since July 2013, 20 trainee participants have completed the quality improvement curriculum within the Indiana University Department of Otolaryngology–Head & Neck Surgery, including 7 otolaryngology residents, 6 otolaryngology-bound medical students, and 7 psychiatry residents. Nine faculty and staff attended. Participants were highly satisfied with the quality and effectiveness of the program. Following program implementation, 2 otolaryngology residents and 2 medical students initiated ... περισσότερα »
Antibiotic and Duration of Perioperative Prophylaxis Predicts Surgical Site Infection in Head and Neck Surgery
Antibiotic and Duration of Perioperative Prophylaxis Predicts Surgical Site Infection in Head and Neck Surgery: Objective To examine the effect of giving antibiotics on the day of surgery (DOS) vs DOS and first postoperative day (DOS+1) for prophylaxis against surgical site infection (SSI) in clean-contaminated head and neck surgery (CCHNS). Study Design Retrospective multi-institution analysis using University HealthSystem Consortium data. Methods A multivariate logistic regression model of 8836 discharge records from patients undergoing CCHNS was used to determine the odds of SS...περισσότερα »
Five years real-life experience with raltegravir in a large HIV centre
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Raltegravir was the first licensed integrase inhibitor. Real-life experience is informative and complements trial data. We therefore evaluated raltegravir use in adults in a large HIV treatment centre. From pharmacy and departmental HIV database records, we identified all adults taking ≥1 dose of raltegravir from first availability to the end of November 2012. Data were […]
Distance from care predicts in-hospital mortality in HIV-infected patients with severe sepsis from rural and semi-rural Virginia, USA
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
There are few data regarding outcomes from severe sepsis for HIV-infected patients living in rural or semi-rural settings. We aim to describe the characteristics and predictors of mortality in HIV-infected patients admitted with severe sepsis to the University of Virginia located in semi-rural Charlottesville, Virginia, USA. We queried the University of Virginia Clinical Data Repository […]
Sexual health screening in people living with HIV – are we getting the whole story?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Patients’ notes were audited to evaluate sexual health screening in 385 people living with HIV. A total of 76% were offered sexually transmitted infection (STI) screening; 85% of these accepted; 62% reported regular partners of whom 44% were also people living with HIV. In men who have sex with men (MSM), 64% reported consistent condom […]
Sexually transmitted infection screening uptake and knowledge of sexually transmitted infection symptoms among female sex workers participating in a community randomised trial in Peru
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
This study aims to evaluate condom use, sexually transmitted infection (STI) screening, and knowledge of STI symptoms among female sex workers in Peru associated with sex work venues and a community randomised trial of STI control. One component of the Peru PREVEN intervention conducted mobile-team outreach to female sex workers to reduce STIs and increase […]
The association between HPV, intraepithelial lesions and HIV-1 shedding in anogenital specimens in two contrasting populations: Senegalese women and American MSM
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
In light of observational evidence showing an association between human papillomavirus (HPV) and HIV acquisition risk, the potential of HPV vaccination as a HIV prevention strategy is being considered. However, the relationship between HPV and HIV infectiousness is unclear. In this analysis, the relationship between HPV and anogenital HIV shedding (a proxy for transmissibility) was […]
Validation of the Chinese Translation of the Spatial Hearing Questionnaire and Its Short Form
Purpose Few questionnaires address how to measure spatial hearing ability in complex listening situations. The purpose of the study was (a) to validate the Chinese translation of the Spatial Hearing Questionnaire (C-SHQ) among Chinese participants and (b) to provide a shortened version for the purpose of clinical screening. Method This was a cross-sectional study. The C-SHQ was developed from the process of translation and back-translation of the original 24-item, English version (Tyler, Perreau, & Ji, 2009). The C-SHQ was administered to 146 patients at the Department of Otolaryngo...περισσότερα »
Increased expression of bitter taste receptors in human allergic nasal mucosa and their contribution to the shrinkage of human nasal mucosa
Summary Objective Bitter taste receptors (TAS2Rs) are expressed in the extraoral tissues, where they possess various physiological functions. The present study is to characterize TAS2Rs expression in normal and allergic nasal mucosa, and analyze nasal symptom after challenge with bitter tastes to evaluate their pathophysiological function in normal and allergic nasal mucosa. Methods The expression levels of TAS2Rs (TAS2R4, 5, 7, 10, 14, 39, and 43) in nasal mucosa were investigated by real time PCR, Western blot, and Immunohistochemistry. The expression levels of TAS2Rs and Ca2+ ...περισσότερα »
Anatomic Changes Caused by Endoscopic Endonasal Transsphenoidal Surgery and Their Effects on Nasal Functions
Anatomic Changes Caused by Endoscopic Endonasal Transsphenoidal Surgery and Their Effects on Nasal Functions: Objective We evaluated postoperative changes in nasal cavity dimensions and their effects on nasal functions and symptoms. Study Design Case series with chart review. Setting Tertiary referral center. Subjects and Methods We studied patients who underwent binostril, 4-hand endoscopic endonasal transsphenoidal approach surgery with the bilateral modified nasoseptal rescue flap technique. Pre- and postoperative paranasal computed tomography scans were used to assess nasal ... περισσότερα »
ALK Fusion in Colorectal Carcinoma
Purpose:Chromosomal translocations in the anaplastic lymphoma kinase (<i>ALK</i>) gene have been identified as oncogenic drivers in lung adenocarcinomas and other tumors, recently including rare cases of colorectal carcinoma (CRC). We identified a patient with refractory metastatic CRC harboring a <i>STRN-ALK</i> gene fusion who achieved an exceptional clinical benefit to the ALK inhibitor ceritinib. Our goal… Continue reading ALK Fusion in Colorectal Carcinoma
Nipple-sparing mastectomy: A contemporary perspective
Increasing numbers of women are undergoing nipple-sparing mastectomy, and evidence to support its use for cancer treatment and prophylaxis is expanding. An understanding of technical aspects and pitfalls of the procedure is paramount to ensure that the best results are attained. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc. from #ORL-AlexandrosSfakianakis via ola Kala on… Continue reading Nipple-sparing mastectomy: A contemporary perspective
False Hyperchloremia During Anesthesia in 2 Patients Treated With Potassium Bromide for Refractory Epilepsy.
No abstract available from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1RFn4y6 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XZWDG4 via IFTTT
Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated skeletal muscle from old rats
Skeletal muscle insulin resistance is associated with many common age-related diseases, but moderate calorie restriction (CR) can substantially elevate glucose uptake by insulin-stimulated skeletal muscle from both young and old rats. The current study evaluated the isolated epitrochlearis muscle from ~24.5-mo-old rats that were either fed ad libitum (AL) or subjected to CR (consuming ~65%… Continue reading Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated skeletal muscle from old rats
LincRNA-ROR promotes invasion, metastasis and tumor growth in pancreatic cancer through activating ZEB1 pathway
Publication date: 1 May 2016 Source:Cancer Letters, Volume 374, Issue 2 Author(s): Han-xiang Zhan, Yao Wang, Ce Li, Jian-wei Xu, Bin Zhou, Jian-kang Zhu, Hai-feng Han, Lei Wang, Yun-shan Wang, San-yuan Hu Pancreatic cancer (PC) remains one of the most lethal malignant tumors; early distant metastasis commonly results in poor prognosis. Recent studies confirmed the… Continue reading LincRNA-ROR promotes invasion, metastasis and tumor growth in pancreatic cancer through activating ZEB1 pathway
Elevational spatial compounding for enhancing image quality in echocardiography
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 42 δευτερόλεπτα
Introduction Echocardiography is commonly used in clinical practice for the real-time assessment of cardiac morphology and function. Nevertheless, due to the nature of the data acquisition, cardiac ultrasound images are often corrupted by a range of acoustic artefacts, including acoustic noise, speckle and shadowing. Spatial compounding techniques have long been recognised for their ability to […]
Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated skeletal muscle from old rats
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 42 δευτερόλεπτα
Skeletal muscle insulin resistance is associated with many common age-related diseases, but moderate calorie restriction (CR) can substantially elevate glucose uptake by insulin-stimulated skeletal muscle from both young and old rats. The current study evaluated the isolated epitrochlearis muscle from ~24.5-mo-old rats that were either fed ad libitum (AL) or subjected to CR (consuming ~65% […]
Interleukin-17 Impairs Salivary Tight Junction Integrity in Sjögrens Syndrome
Sjögren's syndrome (SS) is an inflammatory autoimmune disease that causes secretory dysfunction of the salivary glands. It has been reported that proinflammatory cytokine interleukin-17 (IL-17) was elevated and tight junction (TJ) integrity disrupted in minor salivary glands from SS patients. However, whether the elevated IL-17 in SS affects TJ integrity and thereby alters the function of salivary gland is unknown. Here, by using nonobese diabetic (NOD) mice as SS model, we found that the stimulated salivary flow rate was significantly decreased in NOD mice. Lymphocyte infiltrati... περισσότερα »
Mast Cells Contribute to Porphyromonas gingivalis-induced Bone Loss
Periodontitis is a chronic inflammatory and bone-destructive disease. Development of periodontitis is associated with dysbiosis of the microbial community, which may be caused by periodontal bacteria, such as *Porphyromonas gingivalis*. Mast cells are sentinels at mucosal surfaces and are a potent source of inflammatory mediators, including tumor necrosis factors (TNF), although their role in the pathogenesis of periodontitis remains to be elucidated. This study sought to determine the contribution of mast cells to local bone destruction following oral infection with *P. gingivalis... περισσότερα »
From Artisanal to CAD-CAM Blocks: State of the Art of Indirect Composites
Indirect composites have been undergoing an impressive evolution over the last few years. Specifically, recent developments in computer-aided design–computer-aided manufacturing (CAD-CAM) blocks have been associated with new polymerization modes, innovative microstructures, and different compositions. All these recent breakthroughs have introduced important gaps among the properties of the different materials. This critical state-of-the-art review analyzes the strengths and weaknesses of the different varieties of CAD-CAM composite materials, especially as compared with direct and...περισσότερα »
An observational case series on dermatoscopic patterns of fading melanocytic naevi
Abstract Background/Objectives The prevalence of melanocytic naevi falls with age. It has been postulated that this could be due to spontaneous involution (fading). Our objective was to provide dermatoscopic evidence of fading naevi and to describe the patterns of fading observed. Methods Serial dermatoscopic images of naevi demonstrating fading were collected from a set of 25 000 images. Any naevi that showed significant fading, as compared to previous imaging of the same lesion, were included in the analysis. Results A total of 47 naevi in 21 patients were found to have signi... περισσότερα »
Angiopoietin-2 concentration in serum is associated with severe asthma phenotype
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Several proangiogenic molecules have been implicated in the pathogenies of asthmatic inflammation and remodeling. The aim of the study was to compare the concentration of proangiogenic factors in the sera of a… from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24Ag0Kd via IFTTT
Neural Correlates of Phonetic Learning in Postlingually Deafened Cochlear Implant Listeners.
Objective: The present training study aimed to examine the fine-scale behavioral and neural correlates of phonetic learning in adult postlingually deafened cochlear implant (CI) listeners. The study investigated whether high variability identification training improved phonetic categorization of the /ba/-/da/ and /wa/-/ja/ speech contrasts and whether any training-related improvements in phonetic perception were correlated with neural markers associated with phonetic learning. It was hypothesized that training would sharpen phonetic boundaries for the speech contrasts and that chang... περισσότερα »
Effects of Modified Hearing Aid Fittings on Loudness and Tone Quality for Different Acoustic Scenes.
Objective: To compare loudness and tone-quality ratings for sounds processed via a simulated five-channel compression hearing aid fitted using NAL-NL2 or using a modification of the fitting designed to be appropriate for the type of listening situation: speech in quiet, speech in noise, music, and noise alone. Design: Ratings of loudness and tone quality were obtained for stimuli presented via a loudspeaker in front of the participant. For normal-hearing participants, levels of 50, 65, and 80 dB SPL were used. For hearing-impaired participants, the stimuli were processed via a simul... περισσότερα »
Intelligibility of the Patient's Speech Predicts the Likelihood of Cochlear Implant Success in Prelingually Deaf Adults.
Objectives: The objective of this study was to determine the validity and clinical applicability of intelligibility of the patient's own speech, measured via a Vowel Identification Test (VOW), as a predictor of speech perception for prelingually deafened adults after 1 year of cochlear implant use. Specifically, the objective was to investigate the probability that a prelingually deaf patient, given a VOW score above (or below) a chosen cutoff point, reaches a postimplant speech perception score above (or below) a critical value. High predictive values for VOW could support preimpla... περισσότερα »
A Comparison of Alternating Polarity and Forward Masking Artifact-Reduction Methods to Resolve the Electrically Evoked Compound Action Potential.
Objective: Cochlear implant manufacturers utilize different artifact-reduction methods to measure electrically evoked compound action potentials (ECAPs) in the clinical software. Two commercially available artifact-reduction techniques include forward masking (FwdMsk) and alternating polarity (AltPol). AltPol assumes that responses to the opposing polarities are equal, which is likely problematic. On the other hand, FwdMsk can yield inaccurate waveforms if the masker does not effectively render all neurons into a refractory state. The goal of this study was to compare ECAP threshold...περισσότερα »
Neural Correlates of Phonetic Learning in Postlingually Deafened Cochlear Implant Listeners.
Objective: The present training study aimed to examine the fine-scale behavioral and neural correlates of phonetic learning in adult postlingually deafened cochlear implant (CI) listeners. The study investigated whether high variability identification training improved phonetic categorization of the /ba/-/da/ and /wa/-/ja/ speech contrasts and whether any training-related improvements in phonetic perception were correlated with neural markers associated with phonetic learning. It was hypothesized that training would sharpen phonetic boundaries for the speech contrasts and that chang... περισσότερα »
Effects of Modified Hearing Aid Fittings on Loudness and Tone Quality for Different Acoustic Scenes.
Objective: To compare loudness and tone-quality ratings for sounds processed via a simulated five-channel compression hearing aid fitted using NAL-NL2 or using a modification of the fitting designed to be appropriate for the type of listening situation: speech in quiet, speech in noise, music, and noise alone. Design: Ratings of loudness and tone quality were obtained for stimuli presented via a loudspeaker in front of the participant. For normal-hearing participants, levels of 50, 65, and 80 dB SPL were used. For hearing-impaired participants, the stimuli were processed via a simul... περισσότερα »
Intelligibility of the Patient's Speech Predicts the Likelihood of Cochlear Implant Success in Prelingually Deaf Adults.
Objectives: The objective of this study was to determine the validity and clinical applicability of intelligibility of the patient's own speech, measured via a Vowel Identification Test (VOW), as a predictor of speech perception for prelingually deafened adults after 1 year of cochlear implant use. Specifically, the objective was to investigate the probability that a prelingually deaf patient, given a VOW score above (or below) a chosen cutoff point, reaches a postimplant speech perception score above (or below) a critical value. High predictive values for VOW could support preimpla... περισσότερα »
A Comparison of Alternating Polarity and Forward Masking Artifact-Reduction Methods to Resolve the Electrically Evoked Compound Action Potential.
Objective: Cochlear implant manufacturers utilize different artifact-reduction methods to measure electrically evoked compound action potentials (ECAPs) in the clinical software. Two commercially available artifact-reduction techniques include forward masking (FwdMsk) and alternating polarity (AltPol). AltPol assumes that responses to the opposing polarities are equal, which is likely problematic. On the other hand, FwdMsk can yield inaccurate waveforms if the masker does not effectively render all neurons into a refractory state. The goal of this study was to compare ECAP threshold...περισσότερα »
Neural Correlates of Phonetic Learning in Postlingually Deafened Cochlear Implant Listeners.
Objective: The present training study aimed to examine the fine-scale behavioral and neural correlates of phonetic learning in adult postlingually deafened cochlear implant (CI) listeners. The study investigated whether high variability identification training improved phonetic categorization of the /ba/-/da/ and /wa/-/ja/ speech contrasts and whether any training-related improvements in phonetic perception were correlated with neural markers associated with phonetic learning. It was hypothesized that training would sharpen phonetic boundaries for the speech contrasts and that chang... περισσότερα »
Effects of Modified Hearing Aid Fittings on Loudness and Tone Quality for Different Acoustic Scenes.
Objective: To compare loudness and tone-quality ratings for sounds processed via a simulated five-channel compression hearing aid fitted using NAL-NL2 or using a modification of the fitting designed to be appropriate for the type of listening situation: speech in quiet, speech in noise, music, and noise alone. Design: Ratings of loudness and tone quality were obtained for stimuli presented via a loudspeaker in front of the participant. For normal-hearing participants, levels of 50, 65, and 80 dB SPL were used. For hearing-impaired participants, the stimuli were processed via a simul... περισσότερα »
Intelligibility of the Patient's Speech Predicts the Likelihood of Cochlear Implant Success in Prelingually Deaf Adults.
Objectives: The objective of this study was to determine the validity and clinical applicability of intelligibility of the patient's own speech, measured via a Vowel Identification Test (VOW), as a predictor of speech perception for prelingually deafened adults after 1 year of cochlear implant use. Specifically, the objective was to investigate the probability that a prelingually deaf patient, given a VOW score above (or below) a chosen cutoff point, reaches a postimplant speech perception score above (or below) a critical value. High predictive values for VOW could support preimpla... περισσότερα »
A Comparison of Alternating Polarity and Forward Masking Artifact-Reduction Methods to Resolve the Electrically Evoked Compound Action Potential.
Objective: Cochlear implant manufacturers utilize different artifact-reduction methods to measure electrically evoked compound action potentials (ECAPs) in the clinical software. Two commercially available artifact-reduction techniques include forward masking (FwdMsk) and alternating polarity (AltPol). AltPol assumes that responses to the opposing polarities are equal, which is likely problematic. On the other hand, FwdMsk can yield inaccurate waveforms if the masker does not effectively render all neurons into a refractory state. The goal of this study was to compare ECAP threshold...περισσότερα »
Angiopoietin-2 concentration in serum is associated with severe asthma phenotype
Several proangiogenic molecules have been implicated in the pathogenies of asthmatic inflammation and remodeling. The aim of the study was to compare the concentration of proangiogenic factors in the sera of a... from #ENT via xlomafota13 on Inoreader http://ift.tt/24Ag0Kd via IFTTT
High occurrence of myelodysplasia after chemotherapy and 177Lu octreotate PRRT
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Introduction: Peptide radionuclide receptor therapy (PRRT) is associated with high tumor control rate and early toxicity seems acceptable. However, long-term hematological toxicity is rarely described. Materials and methods: Twenty patients treated with 177Lu DOTATATE PRRT (4 cycles every 8 weeks, 7.5GBq/injection) between 2004 and 2011 for progressive gastro-entero-pancreatic neuroendocrine tumor (GEP-NETs) had regular hematological follow-up. […]
Study: Participants trust malfunctioning robot during mock fire
from EMS via xlomafota13 on Inoreader http://ift.tt/1TmqbyG
Study: Participants trust malfunctioning robot during mock fire
from EMS via xlomafota13 on Inoreader http://ift.tt/1TmqbyG
Study: Participants trust malfunctioning robot during mock fire
from EMS via xlomafota13 on Inoreader http://ift.tt/1TmqbyG
Study: Participants trust malfunctioning robot during mock fire
from EMS via xlomafota13 on Inoreader http://ift.tt/1TmqbyG
Dexmedetomidine for the Treatment of Hyperactive Delirium Refractory to Haloperidol in Nonintubated ICU Patients: A Nonrandomized Controlled Trial.
[image: wk-health-logo.gif] Objectives: To evaluate the clinical effectiveness, safety, and cost of dexmedetomidine for the treatment of agitated delirium refractory to haloperidol in nonintubated critically ill patients. Design: Nonrandomized, controlled trial. Setting: Intensive care department of a tertiary care nonprofit hospital. Patients: All consecutive admissions to a medical-surgical ICU with a diagnosis of agitated delirium. Interventions: Initial haloperidol titration: all patients received IV bolus doses of haloperidol until agitation was controlled (Richmond Agitation ... περισσότερα »
Neural Correlates of Phonetic Learning in Postlingually Deafened Cochlear Implant Listeners.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective: The present training study aimed to examine the fine-scale behavioral and neural correlates of phonetic learning in adult postlingually deafened cochlear implant (CI) listeners. The study investigated whether high variability identification training improved phonetic categorization of the /ba/-/da/ and /wa/-/ja/ speech contrasts and whether any training-related improvements in phonetic perception were correlated with neural […]
Effects of Modified Hearing Aid Fittings on Loudness and Tone Quality for Different Acoustic Scenes.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective: To compare loudness and tone-quality ratings for sounds processed via a simulated five-channel compression hearing aid fitted using NAL-NL2 or using a modification of the fitting designed to be appropriate for the type of listening situation: speech in quiet, speech in noise, music, and noise alone. Design: Ratings of loudness and tone quality were […]
Intelligibility of the Patient’s Speech Predicts the Likelihood of Cochlear Implant Success in Prelingually Deaf Adults.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives: The objective of this study was to determine the validity and clinical applicability of intelligibility of the patient’s own speech, measured via a Vowel Identification Test (VOW), as a predictor of speech perception for prelingually deafened adults after 1 year of cochlear implant use. Specifically, the objective was to investigate the probability that a […]
A Comparison of Alternating Polarity and Forward Masking Artifact-Reduction Methods to Resolve the Electrically Evoked Compound Action Potential.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective: Cochlear implant manufacturers utilize different artifact-reduction methods to measure electrically evoked compound action potentials (ECAPs) in the clinical software. Two commercially available artifact-reduction techniques include forward masking (FwdMsk) and alternating polarity (AltPol). AltPol assumes that responses to the opposing polarities are equal, which is likely problematic. On the other hand, FwdMsk can yield inaccurate […]
Anatomic Changes Caused by Endoscopic Endonasal Transsphenoidal Surgery and Their Effects on Nasal Functions
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective We evaluated postoperative changes in nasal cavity dimensions and their effects on nasal functions and symptoms. Study Design Case series with chart review. Setting Tertiary referral center. Subjects and Methods We studied patients who underwent binostril, 4-hand endoscopic endonasal transsphenoidal approach surgery with the bilateral modified nasoseptal rescue flap technique. Pre- and postoperative paranasal […]
Antibiotic and Duration of Perioperative Prophylaxis Predicts Surgical Site Infection in Head and Neck Surgery
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective To examine the effect of giving antibiotics on the day of surgery (DOS) vs DOS and first postoperative day (DOS+1) for prophylaxis against surgical site infection (SSI) in clean-contaminated head and neck surgery (CCHNS). Study Design Retrospective multi-institution analysis using University HealthSystem Consortium data. Methods A multivariate logistic regression model of 8836 discharge records […]
Lean Belt Certification: Pathway for Student, Resident, and Faculty Development and Scholarship
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Since July 2013, 20 trainee participants have completed the quality improvement curriculum within the Indiana University Department of Otolaryngology–Head & Neck Surgery, including 7 otolaryngology residents, 6 otolaryngology-bound medical students, and 7 psychiatry residents. Nine faculty and staff attended. Participants were highly satisfied with the quality and effectiveness of the program. Following program implementation, 2 […]
Cholesterol Granuloma Development following Temporal Bone Surgery
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective To describe the clinical presentation and management of patients with cholesterol granulomas (CGs) that develop following temporal bone surgery. Study Design Case series with chart review. Setting Two independent tertiary academic referral centers. Subjects and Methods A multicenter retrospective review was performed to identify all patients between 2001 and 2014 who were diagnosed with […]
Injection Laryngoplasty Using Micronized Acellular Dermis for Vocal Fold Paralysis: Long-term Voice Outcomes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives Micronized acellular dermis has been used for nearly 15 years to correct glottic insufficiency. With previous demonstration of safety and efficacy, this study aims to evaluate intermediate and long-term voice outcomes in those who underwent injection laryngoplasty for unilateral vocal fold paralysis. Technique and timing of injection were also reviewed to assess their impact […]
Transoral Robotic Surgery for Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective To perform a systematic review of the international biomedical literature evaluating the effectiveness, complications, and safety of transoral robotic surgery (TORS) for the treatment of obstructive sleep apnea (OSA). Data Sources PubMed/MEDLINE, Embase, and EMB Reviews databases were searched up to November 27, 2015. Review Methods Two authors systematically and independently searched for articles […]
Neural Correlates of Phonetic Learning in Postlingually Deafened Cochlear Implant Listeners.
Objective: The present training study aimed to examine the fine-scale behavioral and neural correlates of phonetic learning in adult postlingually deafened cochlear implant (CI) listeners. The study investigated whether high variability identification training improved phonetic categorization of the /ba/-/da/ and /wa/-/ja/ speech contrasts and whether any training-related improvements in phonetic perception were correlated with neural markers associated with phonetic learning. It was hypothesized that training would sharpen phonetic boundaries for the speech contrasts and that chang... περισσότερα »
Effects of Modified Hearing Aid Fittings on Loudness and Tone Quality for Different Acoustic Scenes.
Objective: To compare loudness and tone-quality ratings for sounds processed via a simulated five-channel compression hearing aid fitted using NAL-NL2 or using a modification of the fitting designed to be appropriate for the type of listening situation: speech in quiet, speech in noise, music, and noise alone. Design: Ratings of loudness and tone quality were obtained for stimuli presented via a loudspeaker in front of the participant. For normal-hearing participants, levels of 50, 65, and 80 dB SPL were used. For hearing-impaired participants, the stimuli were processed via a simul... περισσότερα »
Intelligibility of the Patient's Speech Predicts the Likelihood of Cochlear Implant Success in Prelingually Deaf Adults.
Objectives: The objective of this study was to determine the validity and clinical applicability of intelligibility of the patient's own speech, measured via a Vowel Identification Test (VOW), as a predictor of speech perception for prelingually deafened adults after 1 year of cochlear implant use. Specifically, the objective was to investigate the probability that a prelingually deaf patient, given a VOW score above (or below) a chosen cutoff point, reaches a postimplant speech perception score above (or below) a critical value. High predictive values for VOW could support preimpla... περισσότερα »
A Comparison of Alternating Polarity and Forward Masking Artifact-Reduction Methods to Resolve the Electrically Evoked Compound Action Potential.
Objective: Cochlear implant manufacturers utilize different artifact-reduction methods to measure electrically evoked compound action potentials (ECAPs) in the clinical software. Two commercially available artifact-reduction techniques include forward masking (FwdMsk) and alternating polarity (AltPol). AltPol assumes that responses to the opposing polarities are equal, which is likely problematic. On the other hand, FwdMsk can yield inaccurate waveforms if the masker does not effectively render all neurons into a refractory state. The goal of this study was to compare ECAP threshold...περισσότερα »
Neural Correlates of Phonetic Learning in Postlingually Deafened Cochlear Implant Listeners.
Objective: The present training study aimed to examine the fine-scale behavioral and neural correlates of phonetic learning in adult postlingually deafened cochlear implant (CI) listeners. The study investigated whether high variability identification training improved phonetic categorization of the /ba/-/da/ and /wa/-/ja/ speech contrasts and whether any training-related improvements in phonetic perception were correlated with neural markers associated with phonetic learning. It was hypothesized that training would sharpen phonetic boundaries for the speech contrasts and that chang... περισσότερα »
Author Guidelines 1
from #ENT via xlomafota13 on Inoreader http://ift.tt/1L4ztwg via IFTTT
Acknowledgements to reviewers
from #ENT via xlomafota13 on Inoreader http://ift.tt/1oO6vpW via IFTTT
Endoscopic Transcanal Retrocochlear Approach to the Internal Auditory Canal with Cochlear Preservation: Pilot Cadaveric Study
Contemporary operative approaches to the internal auditory canal (IAC) require the creation of large surgical portals for visualization with associated morbidity, including hearing loss, vestibular dysfunction, facial nerve injury, and skull base defects that increase the risk of cerebrospinal fluid leak. Transcanal approaches to the IAC have been possible only via a transcochlear technique. To preserve cochlear function, we describe a novel endoscopic transcanal infracochlear approach to the IAC in cadaveric temporal bones. Navigation fiducials were secured on fresh cadaveric hea... περισσότερα »
Modeled Analysis of Entrance of Colloid Suspensions into the Middle Ear Cavity
Otic suspensions have a positive effect on the duration of otorrhea in children with a tympanostomy tube. It is still questionable how eardrops reach the middle ear. We hypothesized that otic suspensions do not pass the tympanostomy tube if the middle ear is dry but pass by diffusion when wet. The median concentration of Evans blue (colorant) in the middle ear was <15.6 mg/mL (lower limit of quantification) when diffusion was impossible but 45.3 µg/mL when diffusion was possible (*P* = .01). When the outward flow was increased to 0.1 mL/h, the concentration of Evans blue in the mi...περισσότερα »
Nonvisualization of Sialoliths during Sialendoscopy
Objectives Analyze the characteristics of patients undergoing interventional sialendoscopy for sialolithiasis whose stones were not visualized intraoperatively. Study Design Case series with chart review. Setting Tertiary care hospital. Subjects and Methods Patients (n = 276) undergoing sialendoscopy between June 2008 and December 2014 were reviewed for patient characteristics, imaging characteristics, and outcomes. Nonvisualization was defined as a sialolith that was documented on imaging preoperatively but not visualized intraoperatively during sialendoscopy, despite succe... περισσότερα »
Orbital Decompression in the Endoscopic Age: The Modified Inferomedial Orbital Strut
Objective Postoperative diplopia occurs in up to 45% of patients following orbital decompression for exophthalmos associated with Graves' orbitopathy. We sought to describe outcomes of our balanced orbital decompression strategy that includes the preservation of a modified inferomedial orbital strut (mIOS). Study Design Case series with chart review. Setting Academic medical center. Subjects and Methods A total of 115 consecutive orbital decompressions were performed on 73 patients (42 bilateral) with Graves' orbitopathy. All patients underwent (1) a balanced decompression t... περισσότερα »
Plasma Proteins Modified by Advanced Glycation Endproducts (AGEs) Reveal Site-specific Susceptibilities to Glycemic Control in Patients with Type 2 Diabetes Genomics and Proteomics
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Protein glycation refers to the reversible reaction between aldoses (or ketoses) and amino groups yielding relatively stable Amadori (or Heyns) products. Consecutive oxidative cleavage reactions of these products or the reaction of amino groups with other reactive substances (e.g. α-dicarbonyls) yield advanced glycation endproducts (AGEs) that can alter the structures and functions of proteins. AGEs […]
Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signalling Microbiology
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The lifecycles of apicomplexan parasites progress in accordance with fluxes in cytosolic Ca2+. Such fluxes are necessary for events like motility and egress from host cells. We used genetically-encoded Ca2+ indicators (GCaMPs) to develop a cell-based phenotypic screen for compounds that modulate Ca2+ signalling in the model apicomplexan Toxoplasma gondii. In doing so, we took […]
Intelligibility of the Patient’s Speech Predicts the Likelihood of Cochlear Implant Success in Prelingually Deaf Adults.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives: The objective of this study was to determine the validity and clinical applicability of intelligibility of the patient’s own speech, measured via a Vowel Identification Test (VOW), as a predictor of speech perception for prelingually deafened adults after 1 year of cochlear implant use. Specifically, the objective was to investigate the probability that a […]
Serum Albumin Stimulates Protein Kinase G-dependent Microneme Secretion in Toxoplasma gondii Microbiology
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Microneme secretion is essential for motility, invasion, and egress in apicomplexan parasites. Although previous studies indicate that Ca2+ and cGMP control microneme secretion, little is known about how these pathways are naturally activated. Here we have developed genetically-encoded indicators for Ca2+ and microneme secretion to better define the signaling pathways that regulate these processes in […]
Neural Correlates of Phonetic Learning in Postlingually Deafened Cochlear Implant Listeners.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objective: The present training study aimed to examine the fine-scale behavioral and neural correlates of phonetic learning in adult postlingually deafened cochlear implant (CI) listeners. The study investigated whether high variability identification training improved phonetic categorization of the /ba/-/da/ and /wa/-/ja/ speech contrasts and whether any training-related improvements in phonetic perception were correlated with neural […]
A Comparison of Alternating Polarity and Forward Masking Artifact-Reduction Methods to Resolve the Electrically Evoked Compound Action Potential.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objective: Cochlear implant manufacturers utilize different artifact-reduction methods to measure electrically evoked compound action potentials (ECAPs) in the clinical software. Two commercially available artifact-reduction techniques include forward masking (FwdMsk) and alternating polarity (AltPol). AltPol assumes that responses to the opposing polarities are equal, which is likely problematic. On the other hand, FwdMsk can yield inaccurate […]
Family-wide characterization of histone binding abilities of human CW domain containing proteins Protein Structure and Folding
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Covalent modifications of histone N-terminal tails play a critical role in regulating chromatin structure and controlling gene expression. These modifications are controlled by histone-modifying enzymes and read out by histone binding proteins. Numerous proteins have been identified as histone modification readers. Here we report the family-wide characterization of histone binding abilities of human CW domain-containing […]
Slope position influences vegetation-atmosphere interactions in a tropical montane cloud forest
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: 1 May 2016 Source:Agricultural and Forest Meteorology, Volume 221 Author(s): Z. Carter Berry, Sybil G. Gotsch, Friso Holwerda, Lyssette E. Muñoz-Villers, Heidi Asbjornsen Throughout a single day, the microclimatic conditions in tropical montane cloud forests vary from strong solar radiation with simultaneous strong atmospheric water demand (high vapor pressure deficit, VPD, values), followed […]
Effects of Modified Hearing Aid Fittings on Loudness and Tone Quality for Different Acoustic Scenes.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objective: To compare loudness and tone-quality ratings for sounds processed via a simulated five-channel compression hearing aid fitted using NAL-NL2 or using a modification of the fitting designed to be appropriate for the type of listening situation: speech in quiet, speech in noise, music, and noise alone. Design: Ratings of loudness and tone quality were […]
Intelligibility of the Patient’s Speech Predicts the Likelihood of Cochlear Implant Success in Prelingually Deaf Adults.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives: The objective of this study was to determine the validity and clinical applicability of intelligibility of the patient’s own speech, measured via a Vowel Identification Test (VOW), as a predictor of speech perception for prelingually deafened adults after 1 year of cochlear implant use. Specifically, the objective was to investigate the probability that a […]
Dietary Supplements: Knowledge and Adverse Event Reporting Among American Medical Society for Sports Medicine Physicians
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
[image: image]Objective: Certain dietary supplements (DSs) used by military populations pose a threat to overall readiness. This study assessed members of the American Medical Society for Sports Medicine (AMSSM) regarding their knowledge of DS use among their patients and reporting of suspected adverse events. Design: A thirteen-question retrospective, cross-sectional, Web-based survey sought data on practices regarding DSs and adverse event reporting. Setting: Anonymous Web-based survey. Participants: Military and civilian sports medicine physicians. Main Outcome Measures: The prima...περισσότερα »
Final 2016 AMSSM Case Abstracts
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
No abstract available from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/217nLTp via IFTTT
Pharmacogenetic Effects of Inhaled Salbutamol on 10-km Time Trial Performance in Competitive Male and Female Cyclists
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
[image: image]Objective: To determine the effects of single nucleotide polymorphisms (SNPs) in the adrenergic β2-receptor gene (ADRB2, rs1042713, and rs1042714) and epithelial Na+ channel gene (SCNN1A, rs2228576) on cycling performance after the inhalation of salbutamol. Design: Randomized double-blind, mixed-model repeated measures. Setting: University Research Setting. Participants: Sixty-nine trained (maximal oxygen consumption: 62.3 ± 7.6 mL·kg−1·min−1) male and female cyclists, aged 19 to 40 years. Interventions: Participants performed two 10-km time trials 60 minutes after the...περισσότερα »
Research Podium Presentations
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
No abstract available from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/1TQk4kG via IFTTT
Masthead
from Neurology via xlomafota13 on Inoreader http://ift.tt/1SgYJkw via IFTTT
Table of Contents
from Neurology via xlomafota13 on Inoreader http://ift.tt/1WUfdyi via IFTTT
Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney
Abstract Metabolic diseases, such as obesity and diabetes, are a serious burden for the health system. Vascular endothelial growth factor (VEGF)-B has been shown to regulate tissue uptake and accumulation of fatty acids and is thus involved in these metabolic diseases. However, the cell-type-specific expression pattern of *Vegfb* and its receptor (VEGFR1, gene *Flt1*) remains unclear. We explore the expression of *Vegfb* and *Flt1* in the murine heart, lung and kidney by utilizing β-galactosidase knock-in mouse models and combining the analysis of reporter gene expression and immu... περισσότερα »
A novel culture system for adult porcine intestinal crypts
Abstract Porcine models are useful for investigating therapeutic approaches to short bowel syndrome and potentially to intestinal stem cell (ISC) transplantation. Whereas techniques for the culture and genetic manipulation of ISCs from mice and humans are well established, similar methods for porcine stem cells have not been reported. Jejunal crypts were isolated from murine, human, and juvenile and adult porcine small intestine, suspended in Matrigel, and co-cultured with syngeneic intestinal subepithelial myofibroblasts (ISEMFs) or cultured without feeder cells in various cultur... περισσότερα »
Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney
Abstract Metabolic diseases, such as obesity and diabetes, are a serious burden for the health system. Vascular endothelial growth factor (VEGF)-B has been shown to regulate tissue uptake and accumulation of fatty acids and is thus involved in these metabolic diseases. However, the cell-type-specific expression pattern of *Vegfb* and its receptor (VEGFR1, gene *Flt1*) remains unclear. We explore the expression of *Vegfb* and *Flt1* in the murine heart, lung and kidney by utilizing β-galactosidase knock-in mouse models and combining the analysis of reporter gene expression and immu... περισσότερα »
Antibiotic and Duration of Perioperative Prophylaxis Predicts Surgical Site Infection in Head and Neck Surgery
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Objective To examine the effect of giving antibiotics on the day of surgery (DOS) vs DOS and first postoperative day (DOS+1) for prophylaxis against surgical site infection (SSI) in clean-contaminated head and neck surgery (CCHNS). Study Design Retrospective multi-institution analysis using University HealthSystem Consortium data. Methods A multivariate logistic regression model of 8836 discharge records […]
Lean Belt Certification: Pathway for Student, Resident, and Faculty Development and Scholarship
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Since July 2013, 20 trainee participants have completed the quality improvement curriculum within the Indiana University Department of Otolaryngology–Head & Neck Surgery, including 7 otolaryngology residents, 6 otolaryngology-bound medical students, and 7 psychiatry residents. Nine faculty and staff attended. Participants were highly satisfied with the quality and effectiveness of the program. Following program implementation, 2 […]
Cholesterol Granuloma Development following Temporal Bone Surgery
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Objective To describe the clinical presentation and management of patients with cholesterol granulomas (CGs) that develop following temporal bone surgery. Study Design Case series with chart review. Setting Two independent tertiary academic referral centers. Subjects and Methods A multicenter retrospective review was performed to identify all patients between 2001 and 2014 who were diagnosed with […]
Injection Laryngoplasty Using Micronized Acellular Dermis for Vocal Fold Paralysis: Long-term Voice Outcomes
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Objectives Micronized acellular dermis has been used for nearly 15 years to correct glottic insufficiency. With previous demonstration of safety and efficacy, this study aims to evaluate intermediate and long-term voice outcomes in those who underwent injection laryngoplasty for unilateral vocal fold paralysis. Technique and timing of injection were also reviewed to assess their impact […]
Transoral Robotic Surgery for Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Objective To perform a systematic review of the international biomedical literature evaluating the effectiveness, complications, and safety of transoral robotic surgery (TORS) for the treatment of obstructive sleep apnea (OSA). Data Sources PubMed/MEDLINE, Embase, and EMB Reviews databases were searched up to November 27, 2015. Review Methods Two authors systematically and independently searched for articles […]
Parathyroid 4D CT and Scintigraphy: What Factors Contribute to Missed Parathyroid Lesions?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Objective To determine the prevalence of missed lesions for parathyroid 4-dimensional computed tomography (4D CT) and scintigraphy and to describe the factors leading to missed lesions for both modalities. Study Design Case series with chart review. Setting Single center, hospital based. Subjects and Methods Forty patients undergoing 4D CT and scintigraphy before parathyroidectomy between July […]
Acute Rhinosinusitis: Prescription Patterns in a Real-World Setting
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Objective Understand real-world prescription patterns for patients presenting with a first diagnosis of ARS and evaluate adherence to published medical guidelines. Study Design Retrospective administrative database analysis. Setting US-based outpatient settings. Methods From a US claims database (MarketScan), 99,033 patients were identified with acute rhinosinusitis (ARS) in 2012 («index»), with a complete medical and prescription […]
Biofilms Role in Chronic Cholesteatomatous Otitis Media: A Pilot Study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Cholesteatoma is a destructive lesion involving the temporal bone, which may induce severe complications due to its expansion and erosion of adjacent structures. Bacterial biofilm plays a crucial role in the pathogenesis of many otolaryngologic inflammatory/infectious chronic diseases. In this pilot study, we investigated, by means of cultural examination and with scanning electron microscope, the […]
Epidemiology of Wire-Bristle Grill Brush Injury in the United States, 2002-2014
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Objectives The purpose of this study was to investigate the epidemiology of wire-bristle grill brush injury. Study Design and Setting Cross-sectional analysis of national databases; literature review. Subjects and Methods The Consumer Product Safety Commission’s National Electronic Injury Surveillance System (NEISS) was used to derive a national weighted estimate of emergency department visits for wire […]
Endoscopic Transcanal Retrocochlear Approach to the Internal Auditory Canal with Cochlear Preservation: Pilot Cadaveric Study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Contemporary operative approaches to the internal auditory canal (IAC) require the creation of large surgical portals for visualization with associated morbidity, including hearing loss, vestibular dysfunction, facial nerve injury, and skull base defects that increase the risk of cerebrospinal fluid leak. Transcanal approaches to the IAC have been possible only via a transcochlear technique. To […]
