Mucosal Lesions in an Allergy Practice
Mucosal Lesions in an Allergy Practice: AbstractThe diagnosis and treatment of mucosal disease with an allergic pathogenesis are challenging. Oral allergy is often a hypersensitivity reaction with variable symptoms and physical exam findings. Clinical diagnosis requires a history of prior allergen exposure, a delay from exposure to clinical findings, and improvement following allergen removal. The past decades have seen great contributions to the field of oral allergy. The aim of this review is to provide an approach to the diagnosis and treatment of oral dermatologic disease with ... περισσότερα »
The middle layer of the silk cocoon supports guided bone regeneration better than unprocessed silk cocoon
Comparison of unprocessed silk cocoon and silk cocoon middle layer membranes for guided bone regeneration: Abstract BackgroundSilk cocoon is composed of multiple layers. The natural silk cocoon containing all layers was cut as a rectangular shape as defined as total group. The inner and outermost layers were removed from the total group and the remained mat was defined as the middle group. The objectives of this study was to compare the total group with the middle group as a barrier membrane for the guided bone regeneration. MethodsThe effects of these materials on the cellular...περισσότερα »
Increasing the survival of transverse rectus abdominis musculocutaneous flaps with a Botulinum Toxin-A Injection: A comparison of surgical and chemical flap delay methods
Increasing the survival of transverse rectus abdominis musculocutaneous flaps with a Botulinum Toxin-A Injection: A comparison of surgical and chemical flap delay methods: Botulinum Toxin type-A (Btx-A) is a commonly used drug for both cosmetic and therapeutic purposes. The effects of Btx-A on skin and muscle flaps and the related mechanisms have been described previously. In this study, we used a rat transverse rectus abdominis musculocutaneous (TRAM) flap model to examine the effects of Btx-A on the skin island, which is perfused by the rectus abdominis muscle according to the ang...περισσότερα »
Freeze-dried and Ready-to-use AlloDerm
Comparison between Freeze-dried and Ready-to-use AlloDerm in Alloplastic Breast Reconstruction: [image: image] Background: AlloDerm, a brand of acellular dermal matrix, is commonly used as an internal hammock to support the tissue expander or permanent implant in breast reconstruction. The aim of our study is to evaluate the complication rates associated with the freeze-dried (FD) AlloDerm and the ready-to-use (RTU) AlloDerm. Methods: This institutional review board–approved retrospective study involved 103 patients who underwent immediate postmastectomy breast reconstructions fro... περισσότερα »
Platysma flap using dual skin paddles
Platysma flap using dual skin paddles: The platysma myocutaneous flap is rarely reported as an option for reconstruction in the head and neck. In our experience it is a reliable flap that is easy to raise, has a limited risk of morbidity at the donor site, and allows for early recommencement of oral function. We report a patient with an unusually aggressive orocutaneous fistula that complicated the simple extraction of teeth. We modified the platysma flap to provide two independent skin paddles so we could reconstruct both the intraoral and cutaneous defects simultaneously with a go... περισσότερα »
Intraorbital aspergilloma: a rare cause of orbital apex syndrome
Intraorbital aspergilloma: a rare cause of orbital apex syndrome: A 43-year-old man presented to our department with weakness of vision, ptosis, proptosis, and impaired eye movement, all on the left side. Magnetic resonance imaging (MRI) (Fig. 1) showed an extraconal mass in the superointernal quadrant of his left eye socket, without extension to the ethmoid sinus. With the presumptive diagnosis of orbital inflammatory pseudotumour, we started him on a course of prednisolone. When there was no improvement, we excised the pearly white, cartilaginous mass through an upper eyelid appro...περισσότερα »
Immediate facial reanimation in oncological parotid surgery with neurorrhaphy of the masseteric-thoracodorsal-facial nerve branch
Immediate facial reanimation in oncological parotid surgery with neurorrhaphy of the masseteric-thoracodorsal-facial nerve branch: The extracranial facial nerve may be sacrificed together with the parotid gland during a radical parotidectomy, and immediate reconstruction of the facial nerve is essential to maintain at least part of its function. We report five patients who had had radical parotidectomy (two with postoperative radiotherapy) and immediate (n=3) or recent (n=2) reconstructions of the masseteric-thoracodorsal-facial nerve branch. The first mimetic musculature movements ... περισσότερα »
Systemic amoxicillin and metronidazole in treating periodontitis
The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: =a systematic review=: Abstract BackgroundThe treatment of periodontitis begins with a non-surgical phase that includes scaling and root planing(SRP) and on occasion the use of systemic antibiotics. The goal was to systematically evaluate in systemic healthy adults the effect of the concomitant administration of amoxicillin (amx) and metronidazole (met) adjunctive to SRP compared to SRP alone. MethodsThe PubMed-MEDLINE, Cochrane-CENTRAL ...περισσότερα »
Host-derived salivary biomarkers in diagnosing periodontal disease: Systematic review and meta-analysis
Host-derived salivary biomarkers in diagnosing periodontal disease: Systematic review and meta-analysis: Abstract Aim To systematically evaluate the accuracy of host-derived salivary biomarkers in the diagnosis of periodontal disease based on the given sensitivity and specificity information. Materials and Methods Studies were eligible for inclusion if they had compared the diagnostic application of salivary biomarkers with clinical examination of periodontal disease. A detailed search was performed in five databases without restrictions on subject age, chronology, or language. Addi... περισσότερα »
Titanium implants coated with UV-irradiated vitamin D precursor and vitamin E: in vivo performance and coating stability
Titanium implants coated with UV-irradiated vitamin D precursor and vitamin E: in vivo performance and coating stability: Abstract Objectives This study aimed at evaluating the biological response of titanium implants coated with UV-irradiated 7-dehydrocholesterol (7-DHC) and vitamin E (VitE) *in vivo* and analyzing the effects of aging on their stability and bioactivity *in vitro*. Material and methods Titanium surfaces were coated with 7-DHC and VitE, UV-irradiated and incubated for 48 h at 23°C to allow cholecalciferol synthesis. The *in vivo* biological response was tested using... περισσότερα »
Pulse-spreading harmonic complex as an alternative carrier for vocoder simulations of cochlear implants
Pulse-spreading harmonic complex as an alternative carrier for vocoder simulations of cochlear implantsa): [image: cm_sbs_024_plain.png] Noise- and sine-carrier vocoders are often used to acoustically simulate the information transmitted by a cochlear implant(CI). However, sine-waves fail to mimic the broad spread of excitation produced by a CI and noise-bands contain intrinsic modulations that are absent in CIs. The present study proposes pulse-spreading harmonic complexes (PSHCs) as an alternative acoustic carrier in vocoders. Sentence-in-noise recognition was measured in 12 nor... περισσότερα »
Compressive sensing with a spherical microphone array
Compressive sensing with a spherical microphone array: A wave expansion method is proposed in this work, based on measurements with a spherical microphone array, and formulated in the framework provided by Compressive Sensing. The method promotes sparse solutions via ℓ1-norm minimization, so that the measured data are represented by few basis functions. This results in fine spatial resolution and accuracy. This publication covers the theoretical background of the method, including experimental results that illustrate some of the fundamental differences with the “conventional” least...περισσότερα »
Best Masking Sound For Tinnitus
Best Masking Sound For Tinnitus: Tinnitus is a condition often described as a “ringing” or “buzzing” sound in the ears. Tinnitus can be continuous or intermittent, and the sound may be loud or soft and subtle. The condition is fairly common, and many people simply adjust to the ongoing sounds in their ears without huge difficulty. For some people, however, the condition can be very loud and extreme. It can interfere with normal hearing, even though the Tinnitus is not necessarily causing the hearing loss. Searching For Relief Tinnitus can appear for many reasons. The top cause is ... περισσότερα »
The Hearing Journal - Current Issue
Mental Well-Being Tightly Linked to Hearing Health [image: image]No abstract available Symptom: Right-Sided Tinnitus [image: image]No abstract available Beyond Hearing Loss: Self-Management in Audiological Practice [image: image]No abstract available Management of Psychosocial Challenges Posed by Communication Breakdowns [image: image]No abstract available Mystery Surrounds Auditory Neuropathy Spectrum Disorder [image: image]No abstract available Complementary Factors in Processing [image: image]No abstract available Education of Audiologists in Underserved Regions [image: image]No abstrac... περισσότερα »
MPR-CT Imaging for Stapes Prosthesis: Accuracy and Clinical Significance.
MPR-CT Imaging for Stapes Prosthesis: Accuracy and Clinical Significance.: Objectives: The aims of this article are: 1) to re-evaluate the accuracy of multiple planar reconstruction computed tomography (MPR-CT) imaging on stapes-prosthesis parameters, and 2) to clarify possible relationships between prosthesis intravestibular depth and postoperative hearing outcomes. Patients: Seventy patients (46 women and 24 men; 32 right and 38 left sides) with the mean age of 40 years (range, 19-62 yr) with clinical otosclerosis. Intervention(s): All patients underwent stapedotomy and were impla...περισσότερα »
Parallel-Transmit-Accelerated 2D Selective RF Excitation MR of the Temporal Bone: Enhanced Resolution of Labyrinthine and IAC Structures.
Parallel-Transmit-Accelerated 2D Selective RF Excitation MR of the Temporal Bone: Enhanced Resolution of Labyrinthine and IAC Structures.: Rationale and Objectives: The purpose of this study was to compare a standard T2 SPACE sequence (standard-SPACE) used in temporal bone imaging at 3 T with a new parallel-transmit-accelerated 2D-selective radio frequency excitation technique for SPACE which was either time-improved or resolution-improved. Materials and Methods: Thirty-two consecutive patients were examined in this IRB-approved study using a standard T2 SPACE sequence, and then a t... περισσότερα »
A Rare Case of Esophageal Dysphagia in Children: Aberrant Right Subclavian Artery.
[image: http:--images.hindawi.com-linkout-hindaw] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *A Rare Case of Esophageal Dysphagia in Children: Aberrant Right Subclavian Artery.* Case Rep Pediatr. 2016;2016:2539374 Authors: Barone C, Carucci NS, Romano C Abstract Dysphagia is an impairment of swallowing that may involve any structures from the mouth to the stomach. Esophageal dysphagia presents with the sensation of food sticking, pain with swallowing, substernal pressure, or chronic heartburn. There are many causes of esophageal dysphagia, such as motility disorders a... περισσότερα »
Neuroanatomical correlates of tube dependency and impaired oral intake after hemispheric stroke.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Neuroanatomical correlates of tube dependency and impaired oral intake after hemispheric stroke.* Eur J Neurol. 2016 Feb 22; Authors: Galovic M, Leisi N, Müller M, Weber J, Tettenborn B, Brugger F, Abela E, Weder B, Kägi G Abstract BACKGROUND AND PURPOSE: Acute stroke patients with severely impaired oral intake are at risk of malnutrition and dehydration. Rapid identification of these patients is necessary to establish early enteral tube feeding. Whether specific lesion location predicts early tube dependency was ... περισσότερα »
Repetitive Transcranial Magnetic Stimulation: a Novel Approach for Treating Oropharyngeal Dysphagia.
[image: http:--production.springer.de-OnlineReso] Related Articles *Repetitive Transcranial Magnetic Stimulation: a Novel Approach for Treating Oropharyngeal Dysphagia.* Curr Gastroenterol Rep. 2016 Feb;18(2):10 Authors: Michou E, Raginis-Zborowska A, Watanabe M, Lodhi T, Hamdy S Abstract In recent years, repetitive transcranial magnetic stimulation, a technique used to produce human central neurostimulation, has attracted increased interest and been applied experimentally in the treatment of dysphagia. This review presents a synopsis of the current research for the application of... περισσότερα »
Current Treatments of Bruxism.
[image: http:--production.springer.de-OnlineReso] Related Articles *Current Treatments of Bruxism.* Curr Treat Options Neurol. 2016 Feb;18(2):10 Authors: Guaita M, Högl B Abstract OPINION STATEMENT: Despite numerous case reports, the evidence for treatment of bruxism is still low. Different treatment modalities (behavioral techniques, intraoral devices, medications, and contingent electrical stimulation) have been applied. A clinical evaluation is needed to differentiate between awake bruxism and sleep bruxism and rule out any medical disorder or medication that could be behind it... περισσότερα »
Objective prediction of pharyngeal swallow dysfunction in dysphagia through artificial neural network modeling.
[image: http:--media.wiley.com-assets-7315-18-Wi] Related Articles *Objective prediction of pharyngeal swallow dysfunction in dysphagia through artificial neural network modeling.* Neurogastroenterol Motil. 2016 Mar;28(3):336-44 Authors: Kritas S, Dejaeger E, Tack J, Omari T, Rommel N Abstract BACKGROUND: Pharyngeal pressure-flow analysis (PFA) of high resolution impedance-manometry (HRIM) with calculation of the swallow risk index (SRI) can quantify swallow dysfunction predisposing to aspiration. We explored the potential use of artificial neural networks (ANN) to model the relat... περισσότερα »
Swallowing in primary progressive aphasia.
[image: http:--ebooks.iospress.nl-content-images] Related Articles *Swallowing in primary progressive aphasia.* NeuroRehabilitation. 2016 Feb 10;38(1):85-92 Authors: Marin Sde M, Bertolucci PH, Marin LF, de Oliveira FF, Wajman JR, Bahia VS, Mansur LL Abstract BACKGROUND: Few studies have described characteristics of swallowing in primary progressive aphasia (PPA) and its variants. OBJECTIVE: To describe and characterize swallowing and eating behaviors of patients with PPA, as well as their correlates with neuropsychiatric symptoms and patterns of communication. METHODS: We studied ...περισσότερα »
Multimodal Swallowing Evaluation with High-Resolution Manometry Reveals Subtle Swallowing Changes in Early and Mid-Stage Parkinson Disease.
[image: http:--ebooks.iospress.nl-content-images] Related Articles *Multimodal Swallowing Evaluation with High-Resolution Manometry Reveals Subtle Swallowing Changes in Early and Mid-Stage Parkinson Disease.* J Parkinsons Dis. 2016 Jan 29; Authors: Jones CA, Ciucci MR Abstract BACKGROUND: Parkinson disease (PD) has detrimental effects on swallowing function. Treatment options are largely behavioral; thus, patients would benefit from an earlier start to therapy. Early swallowing changes in PD are not well-known, so patients do not typically receive swallowing treatment until later ... περισσότερα »
Long-Term use of Modified Dietsin Huntington's Disease: A Descriptive Clinical Practice Analysis on Improving Dietary Enjoyment.
[image: http:--ebooks.iospress.nl-content-images] Related Articles *Long-Term use of Modified Dietsin Huntington's Disease: A Descriptive Clinical Practice Analysis on Improving Dietary Enjoyment.* J Huntingtons Dis. 2016 Feb 3; Authors: Moorhouse B, Fisher CA Abstract Dysphagia is a very common occurrence in Huntington's disease (HD). As such, many people with HD require texture modified diets. This commentary discusses the implications for individuals living long-term on modified diets, including the loss of sensory stimulation and dietary enjoyment. Clinical practice analyses o... περισσότερα »
Physiology Of Drowning: A Review.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Physiology Of Drowning: A Review.* Physiology (Bethesda). 2016 Mar;31(2):147-66 Authors: Bierens JJ, Lunetta P, Tipton M, Warner DS Abstract Drowning physiology relates to two different events: immersion (upper airway above water) and submersion (upper airway under water). Immersion involves integrated cardiorespiratory responses to skin and deep body temperature, including cold shock, physical incapacitation, and hypovolemia, as precursors of collapse and submersion. The physiology of submersion includes fear of ... περισσότερα »
Does a Water Protocol Improve the Hydration and Health Status of Individuals with Thin Liquid Aspiration Following Stroke? A Randomized Controlled Trial.
[image: http:--production.springer.de-OnlineReso] Related Articles *Does a Water Protocol Improve the Hydration and Health Status of Individuals with Thin Liquid Aspiration Following Stroke? A Randomized Controlled Trial.* Dysphagia. 2016 Feb 17; Authors: Murray J, Doeltgen S, Miller M, Scholten I Abstract The benefit of water protocols for individuals with thin liquid aspiration remains controversial, with mixed findings from a small number of randomized controlled trials (RCTs). This study aimed to contribute to the evidence of the effectiveness of water protocols with a particu... περισσότερα »
Editorial: Eosinophilic Esophagitis Dilation in the Community-Try It-You will Like It-But Start Low and Go Slow.
[image: http:--http://ift.tt/1PhFoOl] Related Articles *Editorial: Eosinophilic Esophagitis Dilation in the Community-Try It-You will Like It-But Start Low and Go Slow.* Am J Gastroenterol. 2016 Feb;111(2):214-6 Authors: Richter JE Abstract The saga of esophageal dilation for patients with eosinophilic esophagitis and strictures reads like a historical novel. Currently, data from over 500 eosinophilic esophagitis (EoE) patients now convincingly prove that esophageal dilation is effective for prolonged relief and safe. It can easily be performed in the gastroenterologists community... περισσότερα »
[Efficacy of percutaneous endoscopic gastrostomy in pediatric patients].
[image: http:--journal.yiigle.com-r-cms-jiansuo-] Related Articles *[Efficacy of percutaneous endoscopic gastrostomy in pediatric patients].* Zhonghua Er Ke Za Zhi. 2016 Feb 2;54(2):145-9 Authors: Li HW, Gong ST, Yang M, Chen PY, Xu ZH, Liang CP, Fang TF, Ren L, Liu LY, Li JX, Geng LL Abstract OBJECTIVE: To analyze the efficacy of percutaneous endoscopic gastrostomy (PEG) in pediatric patients. METHOD: From October 2011 to October 2014, children in the gastrointestinal ward of Guangzhou Women and Children's Medical Center received PEG or jejunal tube PEG(JET-PEG). The success rate,...περισσότερα »
A Pilot Study of the Tongue Pull-Back Exercise for Improving Tongue-Base Retraction and Two Novel Methods to Add Resistance to the Tongue Pull-Back.
[image: http:--production.springer.de-OnlineReso] Related Articles *A Pilot Study of the Tongue Pull-Back Exercise for Improving Tongue-Base Retraction and Two Novel Methods to Add Resistance to the Tongue Pull-Back.* Dysphagia. 2016 Feb 9; Authors: Slovarp L, King L, Off C, Liss J Abstract This pilot study investigated the tongue pull-back (TPB) exercise to improve tongue-base retraction as well as two methods to add resistance to the TPB. Surface electromyography (sEMG) to the submental triangle was used as an indication of tongue-base activity on 13 healthy adults during: (1) s... περισσότερα »
Swallowing dysfunction among patients with laryngeal cleft: More than just aspiration?
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Swallowing dysfunction among patients with laryngeal cleft: More than just aspiration?* Int J Pediatr Otorhinolaryngol. 2016 Mar;82:38-42 Authors: Strychowsky JE, Dodrill P, Moritz E, Perez J, Rahbar R Abstract BACKGROUND: The Modified Barium Swallow (MBS) is the most widely utilized instrumental assessment of swallowing disorders in children; however, the exact role in the evaluation of laryngeal clefts remains controversial. METHODS: This study was an IRB-approved retrospective review on patients diagnosed with l... περισσότερα »
Temporal Malignant Solitary Fibrous Tumor.
Temporal Malignant Solitary Fibrous Tumor.:
Iatrogenic Phenol Injury Causing Facial Paralysis With Tympanic Membrane and Ossicular Necrosis.
Iatrogenic Phenol Injury Causing Facial Paralysis With Tympanic Membrane and Ossicular Necrosis.: Objective: To describe a serious iatrogenic injury and propose means of reducing the risk of its reoccurrence. Patients: A 21-year-old man who suffered facial paralysis, complete necrosis of the tympanic membrane, and ossicular discontinuity because of chemical burn from accidental application of copious amounts of topical anesthetic phenol into the ear. Interventions: Conservative management of facial paralysis and delayed reconstruction of the tympanic membrane and ossicular chain. M... περισσότερα »
Risk factors for Barrett’s esophagus : Barrett's esophagus (BE) is a well-recognized precursor for esophageal adenocarcinoma (EAC) and is defined as ≥1 cm segment of salmon colored mucosa extending above the gastroesophageal junction into the tubular esophagus with biopsy confirmation of metaplastic replacement of the normal squamous epithelium by intestinal-type columnar epithelium.
Risk factors for Barrett’s esophagus: ABSTRACT *Barrett's esophagus (BE) is a well-recognized precursor for esophageal adenocarcinoma (EAC) and is defined as ≥1 cm segment of salmon colored mucosa extending above the gastroesophageal junction into the tubular esophagus with biopsy confirmation of metaplastic replacement of the normal squamous epithelium by intestinal-type columnar epithelium.* The incidence of both BE and EAC has been increasing over the past few decades. As a result, preventing the development of BE by identifying and understanding its modifiable and non-modifiabl...περισσότερα »
How do voice restoration methods affect the psychological status of patients after total laryngectomy?
How do voice restoration methods affect the psychological status of patients after total laryngectomy?: Abstract ObjectiveThis study investigated the relationship between psychological well-being and different voice rehabilitation methods in total laryngectomy patients. MethodsThe study enrolled 96 patients who underwent total laryngectomy. The patients were divided into three groups according to the voice rehabilitation method used: esophageal speech (24 patients); a tracheoesophageal fistula and Provox 2 voice prosthesis (57 patients); or an electrolarynx (15 patients). The ... περισσότερα »
Correlation of Obstructive Sleep Apnea and Laryngo-pharyngeal Reflux: pHmetry Study
Correlation of Obstructive Sleep Apnea and Laryngo-pharyngeal Reflux: pHmetry Study: Abstract Objective to study correlation of obstructive sleep apnea (OSA)and laryngo-pharyngeal reflux (LPR). Design A descriptive study. Setting Suez Canal University Hospital, Ismailia, Egypt. Patients 62 patients with polysomnography confirmed OSA. Intervention patients were evaluated with ambulatory 24-hour double channel pH monitoring. Results Mean reflux symptom index in the study group was 9+5.5 and it was > 13 in all patients with severe OSA. Signs of LPR reflux were present in 34 (55%) patien...περισσότερα »
Long term quality of life outcomes following treatment for adult obstructive sleep apnoea: Comparison of upper airway surgery, continuous positive airway pressure and mandibular advancement splints
Long term quality of life outcomes following treatment for adult obstructive sleep apnoea: Comparison of upper airway surgery, continuous positive airway pressure and mandibular advancement splints: [image: cover.gif?v=1&s=46179478ce60d53403034c0f] Abstract Objective Long term quality of life (QOL) outcomes, complications and clinical effectiveness in patients undergoing treatment with upper airway surgery (UAS), continuous positive airway pressure (CPAP) and mandibular advancement splints (MAS) for adult obstructive sleep apnoea (OSA). Design Retrospective cohort study. Setting ... περισσότερα »
Pre-reconstruction of cervical-to-petrous internal carotid artery: An improved technique for treatment of vascular lesions involving internal carotid artery at the lateral skull base
Pre-reconstruction of cervical-to-petrous internal carotid artery: An improved technique for treatment of vascular lesions involving internal carotid artery at the lateral skull base: [image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background Reconstruction of the internal carotid artery (ICA) is an operative challenge for lesions involving the lateral skull base because of excessive blood loss, intraoperative cranial nerve injury, and difficulties in cerebral protection. Methods Between January 2010 and October 2014, 9 patients with vascular lesions at the lateral sk... περισσότερα »
Role of SAMITAL® in the Relief of Chemo-radiation (CT-RT) Induced Oral Mucositis in Head and Neck Cancer Patients
Role of SAMITAL® in the Relief of Chemo-radiation (CT-RT) Induced Oral Mucositis in Head and Neck Cancer Patients: *Conditions*: Head-and-neck Squamous Cell Carcinoma; Oral Mucositis. *Interventions*: Drug: SAMITAL®; Drug: Placebo sachets *Sponsors*: Istituto Oncologico Veneto IRCCS; Indena S.p.A ArmsAssigned Interventions Experimental: SAMITAL® sachets, oral suspension SAMITAL® sachets for oral suspension, 20 mL, four times a day. Drug: SAMITAL® Placebo Comparator: Placebo sachets Placebo sachets for oral suspension, 20 mL, four times a day. Drug: Placebo sachets
the Natural History of Head and Neck Cancer Precursors
Study to Evaluate the Natural History of Head and Neck Cancer Precursors in Taiwan: *Condition*: Head and Neck Neoplasms *Intervention*: *Sponsors*: National Cancer Institute (NCI); National Taiwan University; Academia Sinica, Taiwan; China Medical University, China Oral cancers are ideal candidates for screening, early detection, and secondary prevention given the amenability for visual inspection and specimen collection and the availability of recognized precursors. Yet, there are currently no guidelines for screening, treatment, or follow-up of patients with oral... περισσότερα »
BYL719 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of Head and Neck Who Failed to Respond to Platinum-based Therapy.
An Open Label, Single Arm, Multicenter Phase II Study of BYL719 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of Head and Neck Who Failed to Respond to Platinum-based Therapy.: *Condition*: Recurrent or Metastatic Squamous Cell Carcinoma of Head and Neck *Intervention*: Drug: BYL719 *Sponsor*: Yonsei University One promising approach to the treatment of cancer is inhibition or modulating the crucial signal transduction pathway of PI3K-Akt-mTOR. Several PI3K inhibitors are being tested in the clinical trials for cancer treatment but not for the head and ne... περισσότερα »
Oral corticosteroid prescribing habits of Canadian Otolaryngologist-Head and Neck Surgeons
Abstract Background Oral corticosteroids (OCSs) are widely prescribed in Otolaryngology-Head & Neck surgery (OtoHNS). There is evidence in the literature regarding specific dosing regimens. However, it is not known to what extent these recommendations are being implemented in practice. Methods An anonymous online survey was sent to Canadian Society of Otolaryngology-Head and Neck Surgery members (*N* = 696). Dosing, frequency and tapering of OCSs were assessed in acute rhino-sinusitis (ARS), chronic rhino-sinusitis with (CRSwP) and without polyps (CRSsP), sudden sensori-neural he... περισσότερα »
Decisional conflict in patients considering diagnostic thyroidectomy with indeterminate fine needle aspirate cytopathology
Abstract Background Fine needle aspiration (FNA) cytopathology is the gold standard work-up for thyroid nodules. However, indeterminate lesions are encountered commonly and can lead to difficult treatment decisions. We sought to determine whether patients experienced decisional conflict surrounding management with diagnostic thyroidectomy in the setting of indeterminate FNA results. Methods Patients with indeterminate results of thyroid nodule FNA were prospectively enrolled. All consultations were carried out by three otolaryngologists in a consistent manner. After consultation, ... περισσότερα »
Bilateral Reduction Mammaplasty for Managing Breast Cancer
Is this technique an oncologically safe approach in women with breast cancer and macromastia? *ePlasty, Open Access Journal of Plastic Surgery* from #ENT via xlomafota13 on Inoreader http://ift.tt/1LRK3Sd via IFTTT
Clinical Usage of an Extracellular, Collagen-rich Matrix
How do wounds with different etiologies heal after treatment with this extracellular, collagen-rich matrix? *Wounds* from #ENT via xlomafota13 on Inoreader http://ift.tt/1T5sJB1 via IFTTT
World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Prebiotics
Background: The prevalence of allergic diseases in infants, whose parents and siblings do not have allergy, is approximately 10 % and reaches 20–30 % in those with an allergic first-degree relative. Intestinal microbiota may modulate immunologic and inflammatory systemic responses and, thus, influence development of sensitization and allergy. Prebiotics – non-digestible oligosaccharides that stimulate growth of probiotic bacteria – have been reported to modulate immune responses and their supplementation has been proposed as a preventive intervention.ObjectiveThe World Allergy Org... περισσότερα »
Forkhead Box O1 Regulates Macrophage Polarization Following Staphylococcus aureus Infection: Experimental Murine Data and Review of the Literature
Abstract The functions of macrophages that lead to effective host responses are critical for protection against *Staphylococcus aureus*. Deep tissue-invading *S. aureus* initially countered by macrophages trigger macrophage accumulation and induce inflammatory responses through surface receptors, especially toll-like receptor 2 (TLR2). Here, we found that macrophages formed sporadic aggregates in the liver during infection. Within those aggregates, macrophages co-localized with T cells and were indispensable for their infiltration. In addition, we have focused on the mechanisms un...περισσότερα »
Are the interarytenoid muscles supplied by branches of both the recurrent and superior laryngeal nerves?
[image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis It has been generally accepted that the branches of the internal branch of the superior laryngeal nerve to the interarytenoid muscle are exclusively sensory. However, some experimental studies have suggested that these branches may contain motor axons, and therefore that the interarytenoid muscle is supplied by both the superior and recurrent laryngeal nerves. The aim of this work was to determine whether motor axons to the interarytenoid muscles are present in both laryngeal nerves. Study Design Basic resea...περισσότερα »
Preliminary experiences in trachea scaffold tissue engineering with segmental organ decellularization
[image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis Ideal methods for reconstructing the tracheal structure and restoring tracheal function following damage to the trachea or removal of the trachea have not been developed. The purpose of this study is to evaluate the feasibility of using a whole segment decellularized tracheal scaffold to reconstruct the trachea. Study Design Prospective experimental design. Setting In vivo rabbit model. Methods Trachea scaffolds were created using our previously developed freeze-dry-sonication-sodium dodecyl sulfate (SDS)... περισσότερα »
Intraoperative use of fibrin glue dyed with methylene blue in surgery for branchial cleft anomalies
[image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis We present a new method of optimizing the results of surgery for branchial cleft anomalies based on the intraoperative injection of fibrin glue combined with methylene blue dye. Study Design Retrospective single-center cohort study. Methods The method was applied in 17 patients suffering from branchial anomalies. Six (35.29%) had a preauricular lesion; three (17.65%) had lesions derived from the first arch/pouch/groove (type I), four (23.53%) had lesions derived from the first (type II), one (5.88%) had les...περισσότερα »
Impact of thyroidectomy on cardiac manifestations of Graves' disease
[image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis Graves' disease (GD) has multiple adverse effects on the cardiovascular system. We aimed to examine the outcome of thyroidectomy in patients with cardiac manifestations of GD and evaluate their associated postoperative complications. Study Design Retrospective analysis using a prospectively collected database. Methods A retrospective analysis of our prospectively collected thyroid surgery database was performed. Forty patients with hyperthyroidism due to GD were identified, and each was appropriately age ma... περισσότερα »
Elective central node dissection: Comparison of open to minimally invasive video-assisted approach
[image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis Compare outcomes of concomitant primary thyroidectomy with elective central neck dissection (CND) by the standard open versus minimally invasive video-assisted (MIVA) approach. Study Design Case series chart review, single institution, tertiary referral center. Methods Current Procedural Terminology code 60252 was used to identify patients undergoing CND from February 2005 through June 2012. Therapeutic CND and revision cases were excluded. The MIVA approach was performed in patients with low-risk thyroid c... περισσότερα »
Relationships among measures of physical activity and hearing in African Americans: The Jackson Heart Study
[image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis To evaluate the relationships among measures of physical activity and hearing in the Jackson Heart Study. Study Design Prospective cohort study. Methods We assessed hearing on 1,221 Jackson Heart Study participants who also had validated physical activity questionnaire data on file. Hearing thresholds were measured across frequency octaves from 250 to 8,000 Hz, and various frequency pure-tone averages (PTAs) were constructed, including PTA4 (average of 500, 1,000, 2,000, and 4,000 Hz), PTA-high (average of ...περισσότερα »
New instrumentation in endoscopic medial orbital decompression
[image: cover.gif?v=1&s=91b5c09aa476055defd12367] from #ENT via xlomafota13 on Inoreader http://ift.tt/1QoQDVL via IFTTT
Impact of adenotonsillectomy on nocturnal enuresis in children with sleep-disordered breathing: A prospective study
[image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis To investigate the relationship between sleep-disordered breathing (SDB) and nocturnal enuresis (NE) in children and to prospectively evaluate the effectiveness of adenotonsillectomy on resolving enuresis in indicated SDB patients with NE. Methods We prospectively collected data from 183 children (121 males, mean age 8.17 ± 2.84 years) who underwent adenotonsillectomy to treat SDB between July 2011 and July 2013, and analyzed the prevalence of NE. Before and 3 months after surgery, all parents were requested...περισσότερα »
Brachytherapy for radiotherapy-resistant head and neck cancer: A review of a single center experience
[image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis Despite advances in radiotherapy and chemotherapy treatments for head and neck cancers, the local failure rate is high. In most radiotherapy-resistant cases, surgery is performed; however, some cases are considered unresectable. No standard treatment for these situations has been established. In this study, we review our experience with brachytherapy (BT), which has a different biological mechanism than standard radiotherapy. Methods All patients received prior radiation to the recurrence area. Median high-...περισσότερα »
Maldi-tof ms accelerates pathogen identification and may confer benefit in the outcome of peritoneal dialysis-related peritonitis
Journal of Clinical Microbiology from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1oVdZs6 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UvWo5G via IFTTT
A Study into the Collision-induced Dissociation (CID) Behavior of Cross-Linked Peptides Research
Cross-linking/mass spectrometry resolves protein–protein interactions or protein folds by help of distance constraints. Cross-linkers with specific properties such as isotope-labeled or collision-induced dissociation (CID)-cleavable cross-linkers are in frequent use to simplify the identification of cross-linked peptides. Here, we analyzed the mass spectrometric behavior of 910 unique cross-linked peptides in high-resolution MS1 and MS2 from published… Continue reading A Study into the Collision-induced Dissociation (CID) Behavior of Cross-Linked Peptides Research
Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression Special Issue Articles
Histones, and their modifications, are critical components of cellular programming and epigenetic inheritance. Recently, cancer genome sequencing has uncovered driver mutations in chromatin modifying enzymes spurring high interest how such mutations change histone modification patterns. Here, we applied Top-Down mass spectrometry for the characterization of combinatorial modifications (i.e. methylation and acetylation) on full length histone… Continue reading Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from M... περισσότερα »
Safety and efficacy of sofosbuvir-containing regimens in hepatitis C infected patients with impaired renal function
Liver International from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1RCNn8b via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24ynai4 via IFTTT
Impact of calcium regulation on eccrine sweating and sweating disorders: the view from cells to glands to intact human skin
from Physiology via xlomafota13 on Inoreader http://ift.tt/1L1kzHl via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/216tHMy via IFTTT
Proteomic and Genomic Analyses of the Rvb1 and Rvb2 Interaction Network upon Deletion of R2TP Complex Components Special Issue Articles
The highly conserved yeast R2TP complex, consisting of Rvb1, Rvb2, Pih1, and Tah1, participates in diverse cellular processes ranging from assembly of protein complexes to apoptosis. Rvb1 and Rvb2 are closely related proteins belonging to the AAA+ superfamily and are essential for cell survival. Although Rvbs have been shown to be associated with various protein… Continue reading Proteomic and Genomic Analyses of the Rvb1 and Rvb2 Interaction Network upon Deletion of R2TP Complex Components Special Issue Articles
FOLFOXIRI or FOLFOXIRI plus bevacizumab as first-line treatment of metastatic colorectal cancer: a propensity score-adjusted analysis from two randomized clinical trials
Annals of Oncology from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1RCNnF7 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1nfd1VM via IFTTT
The Proteomic Profile of Deleted in Breast Cancer 1 (DBC1) Interactions Points to a Multifaceted Regulation of Gene Expression Special Issue Articles
Deleted in breast cancer 1 (DBC1) has emerged as an important regulator of multiple cellular processes, ranging from gene expression to cell cycle progression. DBC1 has been linked to tumorigenesis both as an inhibitor of histone deacetylases, HDAC3 and sirtuin 1, and as a transcriptional cofactor for nuclear hormone receptors. However, despite mounting interest in… Continue reading The Proteomic Profile of Deleted in Breast Cancer 1 (DBC1) Interactions Points to a Multifaceted Regulation of Gene Expression Special Issue Articles
Association between long-term lipid profiles and disease severity in a large cohort of patients with inflammatory bowel disease
Digestive Diseases and Sciences from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1oVdX3l via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21FQKjz via IFTTT
Integrative Network Analysis Combined with Quantitative Phosphoproteomics Reveals Transforming Growth Factor-beta Receptor type-2 (TGFBR2) as a Novel Regulator of Glioblastoma Stem Cell Properties Research
Glioblastoma is one of the most malignant brain tumors with poor prognosis and their development and progression are known to be driven by glioblastoma stem cells. Although glioblastoma stem cells lose their cancer stem cell properties during cultivation in serum-containing medium, little is known about the molecular mechanisms regulating signaling alteration in relation to reduction… Continue reading Integrative Network Analysis Combined with Quantitative Phosphoproteomics Reveals Transforming Growth Factor-beta Receptor type-2 (TGFBR2) as a Novel Regulator of Glioblastoma Stem Cel... περισσότερα »
Gastrointestinal tolerance and plasma status of carotenoids, EPA and DHA with a fiber- enriched tube feed in hospitalized patients initiated on tube nutrition: randomized controlled trial
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 40 δευτερόλεπτα
Clinical Nutrition from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1QjadBp via IFTTT
Pancreatoduodenectomy, fifteen years of experience
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 40 δευτερόλεπτα
BMC Cancer from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1nfcbbH via IFTTT
Dietary risk factors for colorectal cancer in Brazil: A case control study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 40 δευτερόλεπτα
Nutrition Journal from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1LsWitI via IFTTT
Three-year monitoring of serum p53 antibody during chemotherapy and surgery for stage IV rectal cancer
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 40 δευτερόλεπτα
Abstract The overexpression of mutant p53 stimulates serum p53 antibody production in patients with colorectal carcinoma even in superficial tumors. Although the short-term perioperative monitoring of serum p53 antibody titers is reported to be useful in predicting tumor recurrence and patient survival in colorectal carcinoma, the clinical utility of the long-term monitoring of serum p53 antibody titers in patients with colorectal cancer remains unknown. Here, we report the 3-year monitoring of serum p53 antibody titers in a 60-year-old man with rectal cancer, clinical stage IV (T2... περισσότερα »
Reactivation of resolved hepatitis B virus infection with immune escape mutations after long-term corticosteroid therapy
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 40 δευτερόλεπτα
Abstract Hepatitis B virus (HBV) reactivation from resolved infection is a serious problem which can frequently lead to severe hepatitis. Generally, it occurs several months after the start of immunosuppressive therapy; however, it sometimes occurs a few years later, even after cessation of therapy. Here we report a patient with de novo HBV infection who had received corticosteroid therapy for pemphigus vulgaris for 6 years. Full-genome HBV sequence analysis using serial serum samples revealed that the patient was infected with HBV subgenotype C2, which had the G1896R mixed mutatio... περισσότερα »
Expanding the phenotype of CRB2 mutations – A new ciliopathy syndrome?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 40 δευτερόλεπτα
Abstract Recessive *CRB2* mutations were recently reported to cause both steroid resistant nephrotic syndrome and prenatal onset ventriculomegaly with kidney disease. We report two Ashkenazi Jewish siblings clinically diagnosed with ciliopathy. Both presented with severe congenital hydrocephalus and mild urinary tract anomalies. One affected sibling also has lung hypoplasia and heart defects. Exome sequencing and further *CRB2* analysis revealed that both siblings are compound heterozygotes for *CRB2* mutations p.N800K and p.Gly1036Alafs*43, and heterozygous for a deleterious spli...περισσότερα »
Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics [Special Issue Articles]
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: inline-graphic-2.gif] The significance of non-histone lysine methylation in cell biology and human disease is an emerging area of research exploration. The development of small molecule inhibitors that selectively and potently target enzymes that catalyze the addition of methyl-groups to lysine residues, such as the protein lysine mono-methyltransferase SMYD2, is an active area of drug discovery. Critical to the accurate assessment of biological function is the ability to identify target enzyme substrates and to define enzyme substrate specificity within the context of the... περισσότερα »
Oral corticosteroid prescribing habits of Canadian Otolaryngologist-Head and Neck Surgeons
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Oral corticosteroids (OCSs) are widely prescribed in Otolaryngology-Head & Neck surgery (OtoHNS). There is evidence in the literature regarding specific dosing regimens. However, it is not known to what extent these recommendations are being implemented in practice. Methods An anonymous online survey was sent to Canadian Society of Otolaryngology-Head and Neck Surgery members […]
Decisional conflict in patients considering diagnostic thyroidectomy with indeterminate fine needle aspirate cytopathology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Fine needle aspiration (FNA) cytopathology is the gold standard work-up for thyroid nodules. However, indeterminate lesions are encountered commonly and can lead to difficult treatment decisions. We sought to determine whether patients experienced decisional conflict surrounding management with diagnostic thyroidectomy in the setting of indeterminate FNA results. Methods Patients with indeterminate results of […]
New Web‐based tool for generating scattergrams to report hearing results
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
(Source: The Laryngoscope) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RCzh6T via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Enhancing Radioiodine Incorporation Into BRAF Mutant Thyroid Cancers With the Combination of Vemurafenib and KTN3379
Enhancing Radioiodine Incorporation Into BRAF Mutant Thyroid Cancers With the Combination of Vemurafenib and KTN3379: *Condition*: Thyroid Cancer *Interventions*: Biological: KTN3379; Drug: vemurafenib *Sponsors*: Kolltan Pharmaceuticals, Inc.; Memorial Sloan Kettering Cancer Center ArmsAssigned Interventions Experimental: Combination of Vemurafenib and KTN3379 Vemurafenib 960 mg po bid KTN3379 1000 mg IV q2weeks Biological: KTN3379 IV every 2 weeks Drug: vemurafenib 960 mg po bid Other Name: Zelboraf Detailed Description:This is a patient pilot study testing the hypothesi... περισσότερα »
Measuring the Effect of Radiation Therapy on Patient Activity Levels
Measuring the Effect of Radiation Therapy on Patient Activity Levels: *Conditions*: Head and Neck Cancer; Prostate Cancer; Breast Cancer; Lung Cancer *Intervention*: *Sponsor*: University of Pittsburgh Groups/Cohorts Head and Neck Subjects with head and neck cancer receiving radiation therapy. Prostate Subjects with prostate cancer receiving radiation therapy. Breast Subjects with breast cancer receiving radiation therapy. Lung Subjects with lung cancer receiving radiation therapy. Detailed Description:At the University of Pittsburgh (UPMC) St. Margaret and UPMC Shadys... περισσότερα »
Nasopharyngeal Tuberculosis
Nasopharyngeal Tuberculosis: Epidemiology, Mechanism of Infection, Clinical Manifestations, and Management: Nasopharyngeal tuberculosis (NPTB) is a noteworthy disease especially in its worldwide spread of the Mycobacterium infection. Although NPTB has been identified in less than one percent of TB cases, recent multiple case reports indicate an either increased awareness or incidence of this disease. The most helpful diagnostic tool is an uncomplicated nasopharyngeal biopsy. However, NPTB is usually ignored because it has varied clinical manifestations and similar presentations with... περισσότερα »
Surgical Approaches to First Branchial Cleft Anomaly Excision: A Case Series
Surgical Approaches to First Branchial Cleft Anomaly Excision: A Case Series: Objectives. First branchial cleft anomalies (BCAs) constitute a rare entity with variable clinical presentations and anatomic findings. Given the high rate of recurrence with incomplete excision, identification of the entire tract during surgical treatment is of paramount importance. The objectives of this paper were to present five anatomic variations of first BCAs and describe the presentation, evaluation, and surgical approach to each one. Methods. A retrospective case review and literature review were p... περισσότερα »
ACE grading—A proposed endoscopic grading system for adenoids
and its clinical correlation via International Journal of Pediatric Otorhinolaryngology Publication date: April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Ajoy Mathew Varghese, P. Naina, Alan T. Cheng, Syed Kamran Asif, Mary Kurien ObjectivesTo propose a novel endoscopic adenoid grading system using a rigid nasal endoscope and to study its correlation with the clinical diagnosis.MethodologyPrerecorded video clips of rigid nasal endoscopy taken during endoscopic adenoidectomy were retrieved. Otolaryngology consultants blinded to the clini...περισσότερα »
Tracheobronchial stents in mucopolysaccharidosis
Tracheobronchial stents in mucopolysaccharidosis via International Journal of Pediatric Otorhinolaryngology Publication date: April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Reiter Karl, Schoen Carola, Ensenauer Regina, Nicolai Thomas, Rudolf M. Huber IntroductionThe mucopolysaccharidoses are a group of hereditary disorders pathologically characterized by tissue accumulation of glycosaminoglycans due to deficient lysosomal metabolism which often leads to progressive airway stenosis and respiratory insufficiency. Relentless and treatment-...περισσότερα »
Embryotoxicity and hair cell toxicity of silver nanoparticles
in zebrafish embryos via International Journal of Pediatric Otorhinolaryngology Publication date: April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Myung Hoon Yoo, Yoon Chan Rah, June Choi, Saemi Park, Hae-Chul Park, Kyoung Ho Oh, Seung Hoon Lee, Soon-Young Kwon ObjectivesThe purpose of the present study was to evaluate silver nanoparticles (AgNP)-induced embryotoxicity and hair cell toxicity during zebrafish development.MethodsWe exposed zebrafish embryos to various AgNP concentrations (30, 60, 120, and 240nM) and evaluated embryotoxicity... περισσότερα »
Paediatric cochlear implant users upgrading to the Nucleus® 6 system
A multicentre clinical evaluation of via International Journal of Pediatric Otorhinolaryngology Publication date: April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Anke Plasmans, Emma Rushbrooke, Michelle Moran, Claire Spence, Leen Theuwis, Andrzej Zarowski, Erwin Offeciers, Beth Atkinson, Jane McGovern, Dimity Dornan, Jaime Leigh, Arielle Kaicer, Rod Hollow, Leigh Martelli, Valerie Looi, Esti Nel, Janine Del Dot, Robert Cowan, Stefan J. Mauger ObjectivesThe aim of this study was to investigate whether experienced paediatric cochlear impl...περισσότερα »
Day-case stapes surgery: Day-case versus inpatient stapes surgery for otosclerosis: a randomized controlled trial
Day-case stapes surgery: Day-case versus inpatient stapes surgery for otosclerosis: a randomized controlled trial: Abstract BackgroundOtosclerosis is characterized by bony deposits in the otic capsule, resulting in stapes fixation and progressive hearing loss. It can be treated effectively by surgically removing (part of) the stapes and replacing it with a prosthesis. Increasingly, stapes surgery is performed as a day-case procedure. The major drive towards day-case surgery has been out of economic considerations. However, it is also increasingly an explicit patient request and le... περισσότερα »
Differential Group Delay of the Frequency Following Response Measured Vertically and Horizontally
Differential Group Delay of the Frequency Following Response Measured Vertically and Horizontally: AbstractThe frequency following response (FFR) arises from the sustained neural activity of a population of neurons that are phase locked to periodic acoustic stimuli. Determining the source of the FFR noninvasively may be useful for understanding the function of phase locking in the auditory pathway to the temporal envelope and fine structure of sounds. The current study compared the FFR recorded with a horizontally aligned (mastoid-to-mastoid) electrode montage and a vertically alig... περισσότερα »
Bildgebung der Kopf-Hals-Region
Bildgebung der Kopf-Hals-Region: ZusammenfassungTumoren der Kopf-Hals-Region sind überwiegend Plattenepithelkarzinome, die der Speicheldrüsen Adenokarzinome, adenoid-zystische Karzinome oder Mukoepidermoidkarzinome. In der Bundesrepublik lag 2011 die Inzidenz von Tumoren der Mundhöhle und des Rachens bei 6839 (5026 Männer und 1813 Frauen), die von Tumoren des Kehlkopfs bei 1878 (1642 Männer und 236 Frauen). Die Inzidenz von Tumoren der Nasenhöhle und der Nasennebenhöhlen war mit 467, die der großen Speicheldrüsen mit 470 deutlich niedriger (www.krebsdaten.de/abfrage). Die vordring... περισσότερα »
New advances in allergy immunotherapy.
New advances in allergy immunotherapy.: Purpose of review: The present article reviews the literature on new methods for administering specific immunotherapy for the treatment of immunoglobulin E-mediated hypersensitivity to airborne and food allergens. The discussion will focus on allergen modifications, and new routes for delivering proteins to allergen-presenting cells. Recent findings: Modified allergens address the issues of supply and standardization, but also have the potential to enhance the allergenicity of the protein, while decreasing the risk of producing severe reaction... περισσότερα »
Rosai–Dorfman Disease Harboring an Activating KRAS K117N Missense Mutation
Rosai–Dorfman Disease Harboring an Activating KRAS K117N Missense Mutation: AbstractRosai–Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy is a rare histiocytic proliferation that is generally considered to be reactive with a benign clinical course. The etiology of RDD is very poorly understood. Recent studies have shown frequent BRAF, NRAS, KRAS, and PIK3CA activating mutations in several histiocytic neoplasms highlighting the emerging importance of the RAF/MEK/ERK pathway in the pathogenesis of these diseases. Here we report a case of Rosai–Dorfman diseas... περισσότερα »
Perfusionsanalyse innerhalb von Speicheldrüsentumoren bei der kontrastmittelverstärkten Sonografie
Perfusionsanalyse innerhalb von Speicheldrüsentumoren bei der kontrastmittelverstärkten Sonografie: Laryngo-Rhino-Otol DOI: 10.1055/s-0042-100282 Hintergrund: Ergänzend zur konventionellen Sonografie erlaubt die kontrastverstärkte Ultraschalluntersuchung (CEUS) eine genauere Perfusionsanalyse von Speicheldrüsentumoren zur Einschätzung ihrer Dignität. Bisher wurde bei der Anwendung von CEUS noch kein Vergleich der Perfusion in unterschiedlichen regions of interest (ROI) innerhalb von Speicheldrüsentumoren durchgeführt. Diese Arbeit soll die Perfusion verschiedener Areale innerhalb ... περισσότερα »
The role of trigeminal function in the sensation of nasal obstruction in chronic rhinosinusitis
The role of trigeminal function in the sensation of nasal obstruction in chronic rhinosinusitis: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis Trigeminal sensation (TS) within the nasal cavity is important for the perception of nasal airflow. The objective of this study is to examine whether impaired TS contributes to the sensation of nasal obstruction in patients with chronic rhinosinusitis (CRS). Study Design Prospective case-control study conducted in a tertiary referral rhinology clinic. Methods Cases consisted of CRS patients with subjective nasal o... περισσότερα »
Does preoperative administration of gabapentin/pregabalin improve postoperative nasal surgery pain?
Does preoperative administration of gabapentin/pregabalin improve postoperative nasal surgery pain?: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives Gabapentin and pregabalin has been shown to reduce postoperative pain effectively. In this meta-analysis, we aimed to assess the role of preoperative gabapentinoids for attenuating postoperative pain after nasal surgery in patients via a meta-analysis of the literature. Data Sources PubMed, Scopus, and Cochrane Database. Methods Literature was screened from inception to December 2015. Nine articles to compare the preoper... περισσότερα »
A second-look tympanoplasty-mastoidectomy strategy for cholesteatoma
Cost analysis and outcomes of a second-look tympanoplasty-mastoidectomy strategy for cholesteatoma: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis To analyze cost and compare cholesteatoma recidivism and hearing outcomes with single-stage and second-look operative strategies. Study Design Retrospective review and cost analysis. Methods Adult and pediatric patients who underwent a tympanoplasty with mastoidectomy for cholesteatoma with a single-stage or second-look operative strategy were identified. Variables included procedure approach, residual or recur...περισσότερα »
Brachytherapy for radiotherapy-resistant head and neck cancer: A review of a single center experience
Brachytherapy for radiotherapy-resistant head and neck cancer: A review of a single center experience: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis Despite advances in radiotherapy and chemotherapy treatments for head and neck cancers, the local failure rate is high. In most radiotherapy-resistant cases, surgery is performed; however, some cases are considered unresectable. No standard treatment for these situations has been established. In this study, we review our experience with brachytherapy (BT), which has a different biological mechanism than st... περισσότερα »
Impact of adenotonsillectomy on nocturnal enuresis in children with sleep-disordered breathing: A prospective study
Impact of adenotonsillectomy on nocturnal enuresis in children with sleep-disordered breathing: A prospective study: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis To investigate the relationship between sleep-disordered breathing (SDB) and nocturnal enuresis (NE) in children and to prospectively evaluate the effectiveness of adenotonsillectomy on resolving enuresis in indicated SDB patients with NE. Methods We prospectively collected data from 183 children (121 males, mean age 8.17 ± 2.84 years) who underwent adenotonsillectomy to treat SDB between July ... περισσότερα »
Impact of thyroidectomy on cardiac manifestations of Graves' disease
Impact of thyroidectomy on cardiac manifestations of Graves' disease: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis Graves' disease (GD) has multiple adverse effects on the cardiovascular system. We aimed to examine the outcome of thyroidectomy in patients with cardiac manifestations of GD and evaluate their associated postoperative complications. Study Design Retrospective analysis using a prospectively collected database. Methods A retrospective analysis of our prospectively collected thyroid surgery database was performed. Forty patients with hyperthyr... περισσότερα »
Intraoperative use of fibrin glue dyed with methylene blue in surgery for branchial cleft anomalies
Intraoperative use of fibrin glue dyed with methylene blue in surgery for branchial cleft anomalies: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis We present a new method of optimizing the results of surgery for branchial cleft anomalies based on the intraoperative injection of fibrin glue combined with methylene blue dye. Study Design Retrospective single-center cohort study. Methods The method was applied in 17 patients suffering from branchial anomalies. Six (35.29%) had a preauricular lesion; three (17.65%) had lesions derived from the first arch/pou... περισσότερα »
Preliminary experiences in trachea scaffold tissue engineering with segmental organ decellularization
Preliminary experiences in trachea scaffold tissue engineering with segmental organ decellularization: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis Ideal methods for reconstructing the tracheal structure and restoring tracheal function following damage to the trachea or removal of the trachea have not been developed. The purpose of this study is to evaluate the feasibility of using a whole segment decellularized tracheal scaffold to reconstruct the trachea. Study Design Prospective experimental design. Setting In vivo rabbit model. Methods Trachea scaff... περισσότερα »
Are the interarytenoid muscles supplied by branches of both the recurrent and superior laryngeal nerves?
Are the interarytenoid muscles supplied by branches of both the recurrent and superior laryngeal nerves?: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis It has been generally accepted that the branches of the internal branch of the superior laryngeal nerve to the interarytenoid muscle are exclusively sensory. However, some experimental studies have suggested that these branches may contain motor axons, and therefore that the interarytenoid muscle is supplied by both the superior and recurrent laryngeal nerves. The aim of this work was to determine whethe... περισσότερα »
Decisional conflict in patients considering diagnostic thyroidectomy with indeterminate fine needle aspirate cytopathology
Decisional conflict in patients considering diagnostic thyroidectomy with indeterminate fine needle aspirate cytopathology: Abstract BackgroundFine needle aspiration (FNA) cytopathology is the gold standard work-up for thyroid nodules. However, indeterminate lesions are encountered commonly and can lead to difficult treatment decisions. We sought to determine whether patients experienced decisional conflict surrounding management with diagnostic thyroidectomy in the setting of indeterminate FNA results. MethodsPatients with indeterminate results of thyroid nodule FNA were pros... περισσότερα »
Oral corticosteroid prescribing habits
Oral corticosteroid prescribing habits of Canadian Otolaryngologist-Head and Neck Surgeons: Abstract BackgroundOral corticosteroids (OCSs) are widely prescribed in Otolaryngology-Head & Neck surgery (OtoHNS). There is evidence in the literature regarding specific dosing regimens. However, it is not known to what extent these recommendations are being implemented in practice. MethodsAn anonymous online survey was sent to Canadian Society of Otolaryngology-Head and Neck Surgery members (*N* = 696). Dosing, frequency and tapering of OCSs were assessed in acute rhino-sinusitis (ARS)... περισσότερα »
A Rare Case of Esophageal Dysphagia in Children: Aberrant Right Subclavian Artery.
[image: http:--images.hindawi.com-linkout-hindaw] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *A Rare Case of Esophageal Dysphagia in Children: Aberrant Right Subclavian Artery.* Case Rep Pediatr. 2016;2016:2539374 Authors: Barone C, Carucci NS, Romano C Abstract Dysphagia is an impairment of swallowing that may involve any structures from the mouth to the stomach. Esophageal dysphagia presents with the sensation of food sticking, pain with swallowing, substernal pressure, or chronic heartburn. There are many causes of esophageal dysphagia, such as motility disorders ... περισσότερα »
Neuroanatomical correlates of tube dependency and impaired oral intake after hemispheric stroke.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Neuroanatomical correlates of tube dependency and impaired oral intake after hemispheric stroke.* Eur J Neurol. 2016 Feb 22; Authors: Galovic M, Leisi N, Müller M, Weber J, Tettenborn B, Brugger F, Abela E, Weder B, Kägi G Abstract BACKGROUND AND PURPOSE: Acute stroke patients with severely impaired oral intake are at risk of malnutrition and dehydration. Rapid identification of these patients is necessary to establish early enteral tube feeding. Whether specific lesion location predicts early tube dependency was... περισσότερα »
Repetitive Transcranial Magnetic Stimulation: a Novel Approach for Treating Oropharyngeal Dysphagia.
[image: http:--production.springer.de-OnlineReso] Related Articles *Repetitive Transcranial Magnetic Stimulation: a Novel Approach for Treating Oropharyngeal Dysphagia.* Curr Gastroenterol Rep. 2016 Feb;18(2):10 Authors: Michou E, Raginis-Zborowska A, Watanabe M, Lodhi T, Hamdy S Abstract In recent years, repetitive transcranial magnetic stimulation, a technique used to produce human central neurostimulation, has attracted increased interest and been applied experimentally in the treatment of dysphagia. This review presents a synopsis of the current research for the application o... περισσότερα »
Current Treatments of Bruxism.
[image: http:--production.springer.de-OnlineReso] Related Articles *Current Treatments of Bruxism.* Curr Treat Options Neurol. 2016 Feb;18(2):10 Authors: Guaita M, Högl B Abstract OPINION STATEMENT: Despite numerous case reports, the evidence for treatment of bruxism is still low. Different treatment modalities (behavioral techniques, intraoral devices, medications, and contingent electrical stimulation) have been applied. A clinical evaluation is needed to differentiate between awake bruxism and sleep bruxism and rule out any medical disorder or medication that could be behind i... περισσότερα »
Objective prediction of pharyngeal swallow dysfunction in dysphagia through artificial neural network modeling.
[image: http:--media.wiley.com-assets-7315-18-Wi] Related Articles *Objective prediction of pharyngeal swallow dysfunction in dysphagia through artificial neural network modeling.* Neurogastroenterol Motil. 2016 Mar;28(3):336-44 Authors: Kritas S, Dejaeger E, Tack J, Omari T, Rommel N Abstract BACKGROUND: Pharyngeal pressure-flow analysis (PFA) of high resolution impedance-manometry (HRIM) with calculation of the swallow risk index (SRI) can quantify swallow dysfunction predisposing to aspiration. We explored the potential use of artificial neural networks (ANN) to model the rela... περισσότερα »
Swallowing in primary progressive aphasia.
[image: http:--ebooks.iospress.nl-content-images] Related Articles *Swallowing in primary progressive aphasia.* NeuroRehabilitation. 2016 Feb 10;38(1):85-92 Authors: Marin Sde M, Bertolucci PH, Marin LF, de Oliveira FF, Wajman JR, Bahia VS, Mansur LL Abstract BACKGROUND: Few studies have described characteristics of swallowing in primary progressive aphasia (PPA) and its variants. OBJECTIVE: To describe and characterize swallowing and eating behaviors of patients with PPA, as well as their correlates with neuropsychiatric symptoms and patterns of communication. METHODS: We studied...περισσότερα »
Multimodal Swallowing Evaluation with High-Resolution Manometry Reveals Subtle Swallowing Changes in Early and Mid-Stage Parkinson Disease.
[image: http:--ebooks.iospress.nl-content-images] Related Articles *Multimodal Swallowing Evaluation with High-Resolution Manometry Reveals Subtle Swallowing Changes in Early and Mid-Stage Parkinson Disease.* J Parkinsons Dis. 2016 Jan 29; Authors: Jones CA, Ciucci MR Abstract BACKGROUND: Parkinson disease (PD) has detrimental effects on swallowing function. Treatment options are largely behavioral; thus, patients would benefit from an earlier start to therapy. Early swallowing changes in PD are not well-known, so patients do not typically receive swallowing treatment until later... περισσότερα »
Long-Term use of Modified Dietsin Huntington's Disease: A Descriptive Clinical Practice Analysis on Improving Dietary Enjoyment.
[image: http:--ebooks.iospress.nl-content-images] Related Articles *Long-Term use of Modified Dietsin Huntington's Disease: A Descriptive Clinical Practice Analysis on Improving Dietary Enjoyment.* J Huntingtons Dis. 2016 Feb 3; Authors: Moorhouse B, Fisher CA Abstract Dysphagia is a very common occurrence in Huntington's disease (HD). As such, many people with HD require texture modified diets. This commentary discusses the implications for individuals living long-term on modified diets, including the loss of sensory stimulation and dietary enjoyment. Clinical practice analyses ... περισσότερα »
Physiology Of Drowning: A Review.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Physiology Of Drowning: A Review.* Physiology (Bethesda). 2016 Mar;31(2):147-66 Authors: Bierens JJ, Lunetta P, Tipton M, Warner DS Abstract Drowning physiology relates to two different events: immersion (upper airway above water) and submersion (upper airway under water). Immersion involves integrated cardiorespiratory responses to skin and deep body temperature, including cold shock, physical incapacitation, and hypovolemia, as precursors of collapse and submersion. The physiology of submersion includes fear of... περισσότερα »
Does a Water Protocol Improve the Hydration and Health Status of Individuals with Thin Liquid Aspiration Following Stroke? A Randomized Controlled Trial.
[image: http:--production.springer.de-OnlineReso] Related Articles *Does a Water Protocol Improve the Hydration and Health Status of Individuals with Thin Liquid Aspiration Following Stroke? A Randomized Controlled Trial.* Dysphagia. 2016 Feb 17; Authors: Murray J, Doeltgen S, Miller M, Scholten I Abstract The benefit of water protocols for individuals with thin liquid aspiration remains controversial, with mixed findings from a small number of randomized controlled trials (RCTs). This study aimed to contribute to the evidence of the effectiveness of water protocols with a partic... περισσότερα »
Editorial: Eosinophilic Esophagitis Dilation in the Community-Try It-You will Like It-But Start Low and Go Slow.
[image: http:--http://ift.tt/1PhFoOl] Related Articles *Editorial: Eosinophilic Esophagitis Dilation in the Community-Try It-You will Like It-But Start Low and Go Slow.* Am J Gastroenterol. 2016 Feb;111(2):214-6 Authors: Richter JE Abstract The saga of esophageal dilation for patients with eosinophilic esophagitis and strictures reads like a historical novel. Currently, data from over 500 eosinophilic esophagitis (EoE) patients now convincingly prove that esophageal dilation is effective for prolonged relief and safe. It can easily be performed in the gastroenterologists communit... περισσότερα »
Magnetic Technique for Sentinel Lymph Node Biopsy in Melanoma: The MELAMAG Trial.
Anninga, B; White, SH; Moncrieff, M; Dziewulski, P; L C Geh, J; Klaase, J; Garmo, H; Anninga, B; White, SH; Moncrieff, M; Dziewulski, P; L C Geh, J; Klaase, J; Garmo, H; Castro, F; Pinder, S; Pankhurst, QA; Hall-Craggs, MA; Douek, M; - view fewer (2016) Magnetic Technique for Sentinel Lymph Node Biopsy in Melanoma: The MELAMAG Trial. Ann Surg Oncol 10.1245/s10434-016-5113-7 . from melanoma2 via als.fakia on Inoreader http://ift.tt/216rz7u via IFTTT
Abstract OT1-02-01: Pilot study of prognostic utility of circulating tumor cells (CTCs) assessed by AdnaGen technology and clinical outcome of patients with stage III breast cancer who completed locoregional and systemic treatment
Background: Detection of high number of CTCs (>5) before initiation of first-line therapy in patients with metastatic breast cancer is associated with shorter progression free survival and overall survival. The most widely used method is CellSearch (Veridex, Raritan, NJ). It relies on immunomagnetic capture of CTCs, using antibodies against the epithelial cell adhesion molecule (EpCAM). Although the US Food and Drug Administration approved CellSearch assay for clinical use. In addition to isolation and enumeration, a promising area of research is genomic CTCs characterization whic... περισσότερα »
Magnetic Technique for Sentinel Lymph Node Biopsy in Melanoma: The MELAMAG Trial.
Anninga, B; White, SH; Moncrieff, M; Dziewulski, P; L C Geh, J; Klaase, J; Garmo, H; Anninga, B; White, SH; Moncrieff, M; Dziewulski, P; L C Geh, J; Klaase, J; Garmo, H; Castro, F; Pinder, S; Pankhurst, QA; Hall-Craggs, MA; Douek, M; - view fewer (2016) Magnetic Technique for Sentinel Lymph Node Biopsy in Melanoma: The MELAMAG Trial. Ann Surg Oncol 10.1245/s10434-016-5113-7 . from melanoma2 via als.fakia on Inoreader http://ift.tt/216rz7u via IFTTT
Abstract OT1-02-01: Pilot study of prognostic utility of circulating tumor cells (CTCs) assessed by AdnaGen technology and clinical outcome of patients with stage III breast cancer who completed locoregional and systemic treatment
Background: Detection of high number of CTCs (>5) before initiation of first-line therapy in patients with metastatic breast cancer is associated with shorter progression free survival and overall survival. The most widely used method is CellSearch (Veridex, Raritan, NJ). It relies on immunomagnetic capture of CTCs, using antibodies against the epithelial cell adhesion molecule (EpCAM). Although the US Food and Drug Administration approved CellSearch assay for clinical use. In addition to isolation and enumeration, a promising area of research is genomic CTCs characterization whic... περισσότερα »
Magnetic Technique for Sentinel Lymph Node Biopsy in Melanoma: The MELAMAG Trial.
Anninga, B; White, SH; Moncrieff, M; Dziewulski, P; L C Geh, J; Klaase, J; Garmo, H; Anninga, B; White, SH; Moncrieff, M; Dziewulski, P; L C Geh, J; Klaase, J; Garmo, H; Castro, F; Pinder, S; Pankhurst, QA; Hall-Craggs, MA; Douek, M; - view fewer (2016) Magnetic Technique for Sentinel Lymph Node Biopsy in Melanoma: The MELAMAG Trial. Ann Surg Oncol 10.1245/s10434-016-5113-7 . from melanoma2 via als.fakia on Inoreader http://ift.tt/216rz7u via IFTTT
Abstract OT1-02-01: Pilot study of prognostic utility of circulating tumor cells (CTCs) assessed by AdnaGen technology and clinical outcome of patients with stage III breast cancer who completed locoregional and systemic treatment
Background: Detection of high number of CTCs (>5) before initiation of first-line therapy in patients with metastatic breast cancer is associated with shorter progression free survival and overall survival. The most widely used method is CellSearch (Veridex, Raritan, NJ). It relies on immunomagnetic capture of CTCs, using antibodies against the epithelial cell adhesion molecule (EpCAM). Although the US Food and Drug Administration approved CellSearch assay for clinical use. In addition to isolation and enumeration, a promising area of research is genomic CTCs characterization whic... περισσότερα »
BVA Voice of the Veterinary Profession survey.
Related Articles BVA Voice of the Veterinary Profession survey. Vet Rec. 2016 Feb 27;178(9):218 Authors: PMID: 26917840 [PubMed – in process] from Speech via xlomafota13 on Inoreader http://ift.tt/1OKOgH9 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21yKNs1 via IFTTT
Commentary on Eagle and Foley: “Cytotoxicity in Human Cell Cultures”
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1LRGg7q via IFTTT
Primary Xenografting Reveals Novel Response Biomarkers
Many promising new cancer drugs proceed through preclinical testing and early-phase trials only to fail in late-stage clinical testing. Thus, improved models that better predict survival outcomes and enable the development of biomarkers are needed to identify patients most likely to respond to and benefit from therapy. Here, we describe a comprehensive approach in which… Continue reading Primary Xenografting Reveals Novel Response Biomarkers
Zenker Diverticulum-Which Surgical Approach Is Superior?
Related Articles Zenker Diverticulum-Which Surgical Approach Is Superior? JAMA Otolaryngol Head Neck Surg. 2016 Feb 25; Authors: Johnson CM, Postma GN Abstract Hypothesis: Endoscopic diverticulostomy is a better first-line treatment than open diverticulectomy for Zenker diverticulum. PMID: 26914440 [PubMed – as supplied by publisher] from Speech via xlomafota13 on Inoreader http://ift.tt/1TCTATv via IFTTT from #Med… Continue reading Zenker Diverticulum-Which Surgical Approach Is Superior?
The In Vivo Chromosome Constitution of Marrow
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1T5pcmb via IFTTT
Current Treatments of Bruxism.
Related Articles Current Treatments of Bruxism. Curr Treat Options Neurol. 2016 Feb;18(2):10 Authors: Guaita M, Högl B Abstract OPINION STATEMENT: Despite numerous case reports, the evidence for treatment of bruxism is still low. Different treatment modalities (behavioral techniques, intraoral devices, medications, and contingent electrical stimulation) have been applied. A clinical evaluation is needed to differentiate… Continue reading Current Treatments of Bruxism.
Cellular Senescence in Radiation-Induced Xerostomia
Head and neck cancer patients treated by radiation commonly suffer from a devastating side effect known as dry-mouth syndrome, which results from the irreversible loss of salivary gland function via mechanisms that are not completely understood. In this study, we used a mouse model of radiation-induced salivary hypofunction to investigate the outcomes of DNA damage… Continue reading Cellular Senescence in Radiation-Induced Xerostomia
Objective prediction of pharyngeal swallow dysfunction in dysphagia through artificial neural network modeling.
Related Articles Objective prediction of pharyngeal swallow dysfunction in dysphagia through artificial neural network modeling. Neurogastroenterol Motil. 2016 Mar;28(3):336-44 Authors: Kritas S, Dejaeger E, Tack J, Omari T, Rommel N Abstract BACKGROUND: Pharyngeal pressure-flow analysis (PFA) of high resolution impedance-manometry (HRIM) with calculation of the swallow risk index (SRI) can quantify swallow dysfunction predisposing to… Continue reading Objective prediction of pharyngeal swallow dysfunction in dysphagia through artificial neural network modeling.
Cancer Stem Cells, Cell Markers, and Radiation Resistance
Reports that a small subset of tumor cells initiate and sustain tumor growth, are resistant to radiation and drugs, and bear specific markers have led to an explosion of cancer stem cell research. These reports imply that the evaluation of therapeutic response by changes in tumor volume is misleading, as volume changes reflect the response… Continue reading Cancer Stem Cells, Cell Markers, and Radiation Resistance
Swallowing in primary progressive aphasia.
Related Articles Swallowing in primary progressive aphasia. NeuroRehabilitation. 2016 Feb 10;38(1):85-92 Authors: Marin Sde M, Bertolucci PH, Marin LF, de Oliveira FF, Wajman JR, Bahia VS, Mansur LL Abstract BACKGROUND: Few studies have described characteristics of swallowing in primary progressive aphasia (PPA) and its variants. OBJECTIVE: To describe and characterize swallowing and eating behaviors of… Continue reading Swallowing in primary progressive aphasia.
Rabbit common calcanean tendon as an animal model: ultrasonographic anatomy and morphometry
*Background:* The aim of the present study was to evaluate usefulness of ultrasonography in assessment of rabbit common calcanean tendon, to describe its ultrasonographic anatomy and to perform morphometric analysis of this structure. *Materials and methods:* Fifteen skeletally-matured New Zealand rabbits were used in the study. Ultrasonographic examinations of common calcanean tendon (CCT) were performed in longitudinal and transverse planes from caudal approach. Sagittal diameters of superficial digital flexor tendon and CCT were measured on longitudinal scans. Sagittal and tr... περισσότερα »
Prevalence of generalised joint hypermobility in school-aged children from east-central European region
*Background:* There is no literature regarding joint mobility in children of the Central and Eastern Europe. Studies describing clinical characteristics and functional outcomes are still needed. The aim of this study was to assess the prevalence of generalised joint hypermobility (GJH) in the group of school-aged children from Vilnius, the capital city of Lithuania, in relation to different cut-off values of the Beighton score (BS), and to identify possible patients with joint hypermobility syndrome. *Materials and methods:* The representative sample of this study was calculated t... περισσότερα »
Morphological predictors of sleep apnoea severity
*Background*: Obstructive sleep apnoea (OSA) does not always depend on obesity but on a certain morphological configuration. The study objective was to verify a hypothesis about a relation between anthropometric features and OSA occurrence and severity. *Materials and methods:* The study involved 138 patients, who had reported in Department and Clinic of Otolaryngology, Warsaw Medical University, due to suspected OSA. Each patient underwent morphological evaluation according to visual analogue scales. The assessment involved nasal septum morphology evaluation according to a 4-grad... περισσότερα »
Comparative anatomical study of standard percutaneous and modified medialised percutaneous Bunnell type repair for artificial Achilles tendon rupture: positive effect of medialisation of the stitches with lower risk of sural nerve injury
*Background:* Less invasive percutaneous acute Achilles tendon rupture (AATR) repair techniques gain popularity because of lower risk of surgical wound complications. But these approaches have an increased risk of sural nerve iatrogenic injury as this sensory nerve is usually not visualised during minimally invasive operative procedures. We compared standard percutaneous Bunnell type and our proposed modified-medialised percutaneous technique in a cadaver study to evaluate potential advantages. *Materials and methods:* Ten pairs of fresh frozen specimens were divided into two grou...περισσότερα »
Does preoperative administration of gabapentin/pregabalin improve postoperative nasal surgery pain?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ConclusionsPreoperative gabapentinoids could attenuate postoperative pain without significant adverse effects in patients who undergo nasal surgery. However, blurred vision may be a handicap that requires consideration for use and education for patients. Further clinical trials will be of help in supporting the results of this study. Level of EvidenceNA Laryngoscope, 2016 (Source: The Laryngoscope) from […]
Brain Injury Alters Volatile Metabolome
Chemical signals arising from body secretions and excretions communicate information about health status as have been reported in a range of animal models of disease. A potential common pathway for diseases to alter chemical signals is via activation of immune function—which is known to be intimately involved in modulation of chemical signals in several species. Based on our prior findings that both immunization and inflammation alter volatile body odors, we hypothesized that injury accompanied by inflammation might correspondingly modify the volatile metabolome to create a signat... περισσότερα »
Our journal: Arjuna's choice, Eklavya's voice.
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Our journal: Arjuna's choice, Eklavya's voice.* Indian J Endocrinol Metab. 2016 Jan-Feb;20(1):3-4 Authors: Kalra S, Unnikrishnan AG PMID: 26904462 [PubMed] from Speech via xlomafota13 on Inoreader http://ift.tt/1TNYHl2 via IFTTT
A Unified Voice Is Needed To Affect Change: Maintenance of Certification in Michigan.
Related Articles *A Unified Voice Is Needed To Affect Change: Maintenance of Certification in Michigan.* Mich Med. 2016 Jan-Feb;115(1):4-5 Authors: Ramirez RM PMID: 26901992 [PubMed - in process] from Speech via xlomafota13 on Inoreader http://ift.tt/1oV5nla via IFTTT
[Efficacy of percutaneous endoscopic gastrostomy in pediatric patients].
[image: http:--journal.yiigle.com-r-cms-jiansuo-] Related Articles *[Efficacy of percutaneous endoscopic gastrostomy in pediatric patients].* Zhonghua Er Ke Za Zhi. 2016 Feb 2;54(2):145-9 Authors: Li HW, Gong ST, Yang M, Chen PY, Xu ZH, Liang CP, Fang TF, Ren L, Liu LY, Li JX, Geng LL Abstract OBJECTIVE: To analyze the efficacy of percutaneous endoscopic gastrostomy (PEG) in pediatric patients. METHOD: From October 2011 to October 2014, children in the gastrointestinal ward of Guangzhou Women and Children's Medical Center received PEG or jejunal tube PEG(JET-PEG). The success rate...περισσότερα »
A Pilot Study of the Tongue Pull-Back Exercise for Improving Tongue-Base Retraction and Two Novel Methods to Add Resistance to the Tongue Pull-Back.
[image: http:--production.springer.de-OnlineReso] Related Articles *A Pilot Study of the Tongue Pull-Back Exercise for Improving Tongue-Base Retraction and Two Novel Methods to Add Resistance to the Tongue Pull-Back.* Dysphagia. 2016 Feb 9; Authors: Slovarp L, King L, Off C, Liss J Abstract This pilot study investigated the tongue pull-back (TPB) exercise to improve tongue-base retraction as well as two methods to add resistance to the TPB. Surface electromyography (sEMG) to the submental triangle was used as an indication of tongue-base activity on 13 healthy adults during: (1) ... περισσότερα »
Swallowing dysfunction among patients with laryngeal cleft: More than just aspiration?
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Swallowing dysfunction among patients with laryngeal cleft: More than just aspiration?* Int J Pediatr Otorhinolaryngol. 2016 Mar;82:38-42 Authors: Strychowsky JE, Dodrill P, Moritz E, Perez J, Rahbar R Abstract BACKGROUND: The Modified Barium Swallow (MBS) is the most widely utilized instrumental assessment of swallowing disorders in children; however, the exact role in the evaluation of laryngeal clefts remains controversial. METHODS: This study was an IRB-approved retrospective review on patients diagnosed with ... περισσότερα »
Brain Injury Alters Volatile Metabolome
Chemical signals arising from body secretions and excretions communicate information about health status as have been reported in a range of animal models of disease. A potential common pathway for diseases to alter chemical signals is via activation of immune function—which is known to be intimately involved in modulation of chemical signals in several species. Based on our prior findings that both immunization and inflammation alter volatile body odors, we hypothesized that injury accompanied by inflammation might correspondingly modify the volatile metabolome to create a signat... περισσότερα »
Are the interarytenoid muscles supplied by branches of both the recurrent and superior laryngeal nerves?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
ConclusionThe present study confirms that the internal branch of the superior laryngeal nerve provides a motor innervation to the interarytenoid muscles. Level of EvidenceN/A. Laryngoscope, 2015 (Source: The Laryngoscope) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RCziYg via IFTTT
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