Publication date: Available online 16 November 2016
Source:International Journal of Oral and Maxillofacial Surgery
Author(s): J.C. Barbalho, R.J. Vasconcellos, H.H. de Morais, L.A.M. Santos, Rde.A. Almeida, H.L. Rêbelo, E.E. Lucena, S.Q. de Araújo
This study aimed to determine the effect of the co-administration of dexamethasone 8mg and nimesulide 100mg given 1h before mandibular third molar surgery. A prospective, randomized, triple-blind, split-mouth clinical trial was developed at the study institution in Pernambuco, Brazil. A pilot study was first performed (95% confidence interval, 80% test power, and 5% error), and a sample of 40 patients aged between 18 and 40 years was selected. The patients were randomized and divided into two groups: dexamethasone+placebo and dexamethasone+nimesulide. The following parameters were evaluated: pain (visual analogue scale), total number of rescue analgesics taken, time taken to first rescue analgesic consumption, oedema, trismus, and patient satisfaction. The paired t-test and the Wilcoxon test were used to compare means. Statistically significant differences were found between the groups in pain values at 2, 4, and 12h postoperative, and in the total number of rescue analgesics and time taken to first rescue analgesic ingestion (P<0.05), with results in favour of dexamethasone+nimesulide administration. Oedema and trismus were similar in the two treatment groups and decreased over time postoperatively. The co-administration of dexamethasone and nimesulide reduces pain intensity and the need for rescue medication after third molar surgery.
http://ift.tt/2g0GkKr
Τετάρτη 16 Νοεμβρίου 2016
Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial
The influence of cortical bone perforation on guided bone regeneration in humans
Source:International Journal of Oral and Maxillofacial Surgery
Author(s): S.A. Danesh-Sani, D. Tarnow, J.K. Yip, R. Mojaver
The purpose of this study was to evaluate the effect of cortical bone perforation on angiogenesis and osteogenesis of the augmented ridge in guided bone regeneration. Eighteen patients who had osseous defects in the mandible were selected. In the test group (n=9), alveolar cortical bone in the area of regeneration was perforated. No decortication was performed in the control group (n=9). Subsequently, defects were augmented by guided bone regeneration using resorbable membrane and bovine bone. After a healing period of 7 months, trephine cores were harvested for histological and histomorphometric analysis of the grafted areas. Histomorphometry demonstrated that the amount of newly formed bone in the test group (27.8%) was greater than that in the control group (25.3%), but the difference was not statistically significant (P=0.13). However, the mean number of microvessels in the test group was significantly higher than that in the control group (P=0.01). This study found that cortical bone perforation favourably affects the amount of new bone formation in the grafted sites after 7 months of healing. Cortical bone perforation significantly increase number of new vessels (angiogenesis) of the regenerated bone. Further randomized clinical trials are required to confirm these results.
http://ift.tt/2fyJgiD
RAS Mutations, and RET/PTC and PAX8/PPAR-gamma Chromosomal Rearrangements Are Also Prevalent in Benign Thyroid Lesions: Implications Thereof and A Systematic Review
http://ift.tt/2f6CuAl
Dysphagie bei Neutropenie unklarer Genese
Laryngo-Rhino-Otol
DOI: 10.1055/s-0042-117637
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
http://ift.tt/2fH58WG
Metastases in the cervical spine from primary head and neck cancers: current concepts of diagnosis and management
Vertebral metastases from primary head and neck cancers are uncommon, and so there are no clear guidelines about management. The spinal cord can be compressed by a vertebral fracture or invasion of a tumour, and may present as an oncological and spinal emergency. The goals of treatment are to relieve pain and maintain neurological function. However, surgical treatments in this group of patients have not been defined, and primary operative treatment of spinal metastases remains controversial. Here we discuss their contemporary management.
http://ift.tt/2f63NuC
The influence of cortical bone perforation on guided bone regeneration in humans
The purpose of this study was to evaluate the effect of cortical bone perforation on angiogenesis and osteogenesis of the augmented ridge in guided bone regeneration. Eighteen patients who had osseous defects in the mandible were selected. In the test group (n=9), alveolar cortical bone in the area of regeneration was perforated. No decortication was performed in the control group (n=9). Subsequently, defects were augmented by guided bone regeneration using resorbable membrane and bovine bone. After a healing period of 7 months, trephine cores were harvested for histological and histomorphometric analysis of the grafted areas.
http://ift.tt/2fiz9LT
Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial
This study aimed to determine the effect of the co-administration of dexamethasone 8mg and nimesulide 100mg given 1h before mandibular third molar surgery. A prospective, randomized, triple-blind, split-mouth clinical trial was developed at the study institution in Pernambuco, Brazil. A pilot study was first performed (95% confidence interval, 80% test power, and 5% error), and a sample of 40 patients aged between 18 and 40 years was selected. The patients were randomized and divided into two groups: dexamethasone+placebo and dexamethasone+nimesulide.
http://ift.tt/2eHKuck
Impact of childhood psoriasis on parents of affected children
Childhood diseases, such as atopic dermatitis, have a negative impact on quality of life (QoL) of parents. How pediatric psoriasis affects a parent's QoL is unknown.
http://ift.tt/2fyiG9o
First report of prevalence c.IVS1+1G>A and del (GJB6-13S1854) mutations in Syrian families with non-syndromic sensorineural hearing loss
Publication date: Available online 15 November 2016
Source:International Journal of Pediatric Otorhinolaryngology
Author(s): Walid AL-Achkar, Bassel AL-Halabi, Bashar Ali, Faten Moassass
ObjectiveMutations in GJB2 and GJB6 genes are a frequent cause of congenital non-syndromic hearing loss (NSHL). Mutational screening has usually focused on coding region of GJB2 gene. A few studies have been conducted on the non-coding region and exon 1. c.IVS1+1G>A (a splice site mutation in GJB2 gene have been detected as disruptive mutation. Del (GJB6 D13S1830) is found in many populations, but del (GJB6 D13S1854) is reported from a few restricted countries. This study was carried out to investigate the prevalence of splice site mutation c.IVS1+1G>A and two common deletions in GJB6 gene as the genetic etiology of hearing impairment in 70 Syrian families.MethodsThe frequency of the c.IVS1+1G>A mutation and two deletions were determined by PCR-RFLP and A multiplex PCR assay.ResultOur results showed a high prevalence of IVS1+1G>A mutation (20%) and del(GJB6-D13S1854) (15.7%) in deaf families. The homozygous genotype (c.IVS1+1G>A/c.IVS1+1G>A) was observed in one family and the compound heterozygous genotypes (c.35delG/c.IVS1+1G>A) and (c.IVS1+1G>A/V153I) were observed in 7 families and one family respectively. Also, the heterozygous state (c.IVS1+1G>A/unknown) was detected in 5 families. The study of del((GJB6-D13S1854) was showed a compound heterozygous genotype del((GJB6-D13S1854)/c.IVS1+1G>A) in the same families (5 families) having heterozygous genotype of c.IVS1+1G>A mutation. Also, del(GJB6-D13S1854) is combined with c.35delG mutation in 2 families and it was observed in the heterozygous state del(GJB6-D13S1854)/unknown) in 4 families. In contrast, the del(GJB6-D13S1830) described in many population was absent in our patients.ConclusionOur findings indicate to significant contribution of the splice site mutation and del(GJB6-D13S1854) in our deaf families and these mutations were important causes of hearing impairment.
http://ift.tt/2eHECjk
Changes in the inner ear structures in cystic fibrosis patients
Publication date: Available online 16 November 2016
Source:International Journal of Pediatric Otorhinolaryngology
Author(s): Henrique F. Pauna, Rafael C. Monsanto, Natsuko Kurata, Michael M. Paparella, Sebahattin Cureoglu
ObjectiveAlthough prolonged use of antibiotics is very common in cystic fibrosis (CF) patients, no studies have assessed the changes in both cochlear and peripheral vestibular systems in this population.MethodsWe used human temporal bones to analyze the density of vestibular dark, transitional, and hair cells in specimens from CF patients who were exposed to several types of antibiotics, as compared with specimens from an age-matched control group with no history of ear disease or antibiotic use. Additionally, we analyzed the changes in the elements of the cochlea (hair cells, spiral ganglion neurons, and the area of the stria vascularis). Data was gathered using differential interference contrast microscopy and light microscopy.ResultsIn the CF group, 83% of patients were exposed to some ototoxic drugs, such as aminoglycosides. As compared with the control group, the density of both type I and type II vestibular hair cells was significantly lower in all structures analyzed; the number of dark cells was significantly lower in the lateral and posterior semicircular canals. We noted a trend toward a lower number of both inner and outer cochlear hair cells at all turns of the cochlea. The number of spiral ganglion neurons in Rosenthal's canal at the apical turn of the cochlea was significantly lower; furthermore, the area of the stria vascularis at the apical turn of the cochlea was significantly smaller.ConclusionsDeterioration of cochlear and vestibular structures in CF patients might be related to their exposure to ototoxic antibiotics. Well-designed case-control studies are necessary to rule out the effect of CF itself.
http://ift.tt/2fiuCJG
Editorial Board
Source:International Journal of Pediatric Otorhinolaryngology, Volume 91
http://ift.tt/2eHGYyN
Utilization of a submental island flap and 3D printed model for skull base reconstruction: Infantile giant cranio-cervicofacial teratoma
Source:International Journal of Pediatric Otorhinolaryngology
Author(s): Diego Preciado, Joshua P. Wiedermann, Arjun Joshi, Aria Jamshidi, Carolyn Conchenour
Transcranial masses in the infant population can leave considerable skull base defects following resection. Traditional reconstructive techniques can result in significant morbidity or poor cosmetic results. We present a case of a large skull base defect in a six week-old infant, after removal of a giant cranio-cervicofacial teratoma, which was reconstructed using a versatile submental island flap. Additionally, preoperative planning and intraoperative navigation was advanced with the use of a 3D constructed model of the patient's mass.
http://ift.tt/2finVY1
Eosinophilic esophagitis as possible complication of aspirin treatment in patient with aspirin-exacerbated respiratory disease
A 44-year-old African American woman with severe, persistent asthma and chronic rhinosinusitis with nasal polyposis due to aspirin-exacerbated respiratory disease (AERD) and allergic rhinoconjunctivitis presented to an outpatient allergy clinic with chief symptoms of epigastric pain and dysphagia while taking aspirin for AERD. The patient was diagnosed with asthma and rhinosinusitis at 31 and 34 years of age, respectively. She initially had symptoms compatible with AERD at 38 years of age when she first reacted to ibuprofen and was diagnosed with sinonasal polyposis.
http://ift.tt/2f21qpr
Common variable immune deficiency associated with pemphigoid
Common variable immune deficiency (CVID) is a primary humoral immunodeficiency of adulthood characterized by reduced levels of at least 2 serum immunoglobulins isotypes and impaired antibody response to polysaccharide antigens. These immunologic defects predispose the patient to recurrent respiratory tract infections, such as recurrent sinusitis, otitis media, bronchitis, and pneumonia.1,2
http://ift.tt/2giptoO
Short-term prophylactic use of C1-inhibitor concentrate in hereditary angioedema
Although most hereditary angioedema (HAE) attacks appear to occur spontaneously, they can be precipitated by emotional stressors or physical triggers, including invasive medical or dental procedures or other physical trauma.1,2 Short-term prophylaxis (STP) is appropriate for patients anticipating situations that might precipitate an HAE attack.1,3–6 HAE guidelines recommend that plasma-derived C1 inhibitor (C1-INH) (10–20 U/kg of Berinert [CSL Behring, King of Prussia, Pennsylvania] or 1,000 to 2,000 U of Cinryze [ViroPharma Biologics, Inc, Lexington, Massachusetts]), administered within 6 hours (within 24 hours for Cinryze) before the stressor event, be used as first-line treatment, if available, in situations in which STP is desired.
http://ift.tt/2f1YA3x
Time-dependent severity change during treatment of pediatric patients hospitalized for acute asthma exacerbations
Pediatric acute asthma exacerbations result in 640,000 emergency department (ED) visits yearly and are the most frequent reason for childhood hospitalization in the United States.1–4 Hospitalization decisions are most often made in the ED, and there is substantial variability of admission rates (median, 24%; interquartile range [IQR], 19%–29%; range, 12%–52%) across US children's hospitals.2 This variability likely results, at least in part, from limited knowledge of what defines need for hospitalization in clinical practice and in National Institutes of Health (NIH) guidelines.
http://ift.tt/2gilusH
Risk Factors of Early Otitis Media in the Danish National Birth Cohort
by Asbjørn Kørvel-Hanquist, Anders Koch, Janni Niclasen, Jesper Dammeye, Jørgen Lous, Sjurdur Frodi Olsen, Preben Homøe
ObjectiveTo assess risk factors of otitis media (OM) in six-months-old children.
MethodThe sample consisted of 69,105 mothers and their children from the Danish National Birth Cohort. The women were interviewed twice during pregnancy and again 6 months after birth. The outcome "one or more" maternal reported episodes of OM at age six months. In total 37 factors were assessed, covering prenatal, maternal, perinatal and postnatal factors.
ResultsAt age six months 5.3% (95% CI 5.1–5.5) of the children had experienced one or more episodes of OM. From the regression analysis, 11 variables were associated with a risk of OM. When a Bonferroni correction was introduced, gender, prematurity, parity, maternal age, maternal self-estimated health, taking penicillin during pregnancy, and terminating breastfeeding before age six months, was associated with a risk of early OM. The adjusted ORs of OM for boys versus girls was 1.30 (95% CI 1.18–1.44). The OR having one sibling versus no siblings was 3.0 (95% CI 2.64–3.41). If the woman had been taking penicillin during pregnancy, the OR was 1.35 (95% CI 1.15–1.58). Children born before 38th gestational week had an increased OR for early OM of 1.49 (95% CI 1.21–1.82). Children of young women had an increased OR of early OM compared to children of older women. Additionally, children of women who rated their own health low compared to those rating their health as high, had an increased OR of 1.38 (95% CI 1.10–1.74). Finally, children being breastfeed less than 6 months, had an increased OR of 1.42 (95% CI 1.28–1.58) compared to children being breastfeed beyond 6 months.
ConclusionThese findings indicate that prenatal factors are of less importance regarding early OM before the age of six months. Postnatal risk factors seem to pose the main risk of early OM.
http://ift.tt/2ghXsPc
Diagnostic guide enabling distinction between taphonomic stains and enamel hypomineralisation in an archaeological context
Source:Archives of Oral Biology, Volume 74
Author(s): Elsa Garot, Christine Couture-Veschambre, David Manton, Vincent Rodriguez, Yannick Lefrais, Patrick Rouas
ObjectiveMolar Incisor Hypomineralisation (MIH) is a structural anomaly that affects the quality of tooth enamel and has important consequences for oral health. The developmentally hypomineralised enamel has normal thickness and can range in colour from white to yellow or brown with or without surface breakdown. The possibility of finding MIH in 'ancient populations' could downplay several current aetiological hypotheses (e.g., dioxin derivatives, bisphenols, antibiotics) without excluding the possible multifactorial aspect of the anomaly. In an archaeological context, chemical elements contained in the burial ground can stain teeth yellow or brown and therefore might create a taphonomic bias. The purpose of the present study is to test a proposed diagnostic guide enabling determination of the pathological or taphonomic cause of enamel discolouration and defects that resemble MIH present on 'ancient teeth'.DesignTwo sample groups including MIH discoloration (n=12 teeth) from living patients, taphonomic discoloration (n=9 teeth) and unknown discoloration (n=2 teeth) from medieval specimens were tested. Three non-destructive methods—Raman spectroscopy, X-ray micro-computed tomography and X-ray fluorescence were utilised.ResultsHypomineralised enamel has decreased mineral density (p<0.0001) and increased phosphate/β-carbonate ratio (p<0.01) compared to normal enamel whereas relative concentrations of manganese, copper, iron and lead are similar. In taphonomic discoloration, relative concentrations of these elements are significantly different (p<0.05) to normal enamel whereas mineral density and Raman spectra profile are comparable.ConclusionsEnamel hypomineralisation can be distinguished from taphonomic staining in archaeological teeth.
http://ift.tt/2f5Sgvk
Diagnostic guide enabling distinction between taphonomic stains and enamel hypomineralisation in an archaeological context
Source:Archives of Oral Biology, Volume 74
Author(s): Elsa Garot, Christine Couture-Veschambre, David Manton, Vincent Rodriguez, Yannick Lefrais, Patrick Rouas
ObjectiveMolar Incisor Hypomineralisation (MIH) is a structural anomaly that affects the quality of tooth enamel and has important consequences for oral health. The developmentally hypomineralised enamel has normal thickness and can range in colour from white to yellow or brown with or without surface breakdown. The possibility of finding MIH in 'ancient populations' could downplay several current aetiological hypotheses (e.g., dioxin derivatives, bisphenols, antibiotics) without excluding the possible multifactorial aspect of the anomaly. In an archaeological context, chemical elements contained in the burial ground can stain teeth yellow or brown and therefore might create a taphonomic bias. The purpose of the present study is to test a proposed diagnostic guide enabling determination of the pathological or taphonomic cause of enamel discolouration and defects that resemble MIH present on 'ancient teeth'.DesignTwo sample groups including MIH discoloration (n=12 teeth) from living patients, taphonomic discoloration (n=9 teeth) and unknown discoloration (n=2 teeth) from medieval specimens were tested. Three non-destructive methods—Raman spectroscopy, X-ray micro-computed tomography and X-ray fluorescence were utilised.ResultsHypomineralised enamel has decreased mineral density (p<0.0001) and increased phosphate/β-carbonate ratio (p<0.01) compared to normal enamel whereas relative concentrations of manganese, copper, iron and lead are similar. In taphonomic discoloration, relative concentrations of these elements are significantly different (p<0.05) to normal enamel whereas mineral density and Raman spectra profile are comparable.ConclusionsEnamel hypomineralisation can be distinguished from taphonomic staining in archaeological teeth.
http://ift.tt/2f5Sgvk
The role of aspirin desensitization in the management of aspirin-exacerbated respiratory disease.
http://ift.tt/2fXleL9
Polyps, asthma, and allergy: what's new.
http://ift.tt/2f5X17R
Practical Performance of the 2015 American Thyroid Association Guidelines for Predicting Tumor Recurrence in Patients with Papillary Thyroid Cancer in South Korea
Thyroid , Vol. 0, No. 0.
http://ift.tt/2eHqSFk
A rare case of gestational thyrotoxicosis as a cause of acute myocardial infarction
Summary
Angina pectoris in pregnancy is unusual and Prinzmetal's angina is much rarer. It accounts for 2% of all cases of angina. It is caused by vasospasm, but the mechanism of spasm is unknown but has been linked with hyperthyroidism in some studies. Patients with thyrotoxicosis-induced acute myocardial infarction are unusual and almost all reported cases have been associated with Graves' disease. Human chorionic gonadotropin hormone-induced hyperthyroidism occurs in about 1.4% of pregnant women, mostly when hCG levels are above 70–80 000 IU/L. Gestational transient thyrotoxicosis is transient and generally resolves spontaneously in the latter half of pregnancy, and specific antithyroid treatment is not required. Treatment with calcium channel blockers or nitrates reduces spasm in most of these patients. Overall, the prognosis for hyperthyroidism-associated coronary vasospasm is good. We describe a very rare case of an acute myocardial infarction in a 27-year-old female, at 9 weeks of gestation due to right coronary artery spasm secondary to gestational hyperthyroidism with free thyroxine of 7.7 ng/dL and TSH <0.07 IU/L.
Learning points:AMI and cardiac arrest due to GTT despite optimal medical therapy is extremely rare.
Gestational hyperthyroidism should be considered in pregnant patients presenting with ACS-like symptoms especially in the setting of hyperemesis gravidarum.
Our case highlights the need for increased awareness of general medical community that GTT can lead to significant cardiac events. Novel methods of controlling GTT as well as medical interventions like ICD need further study.
http://ift.tt/2fYoOIB
A rare case of gestational thyrotoxicosis as a cause of acute myocardial infarction
Summary
Angina pectoris in pregnancy is unusual and Prinzmetal's angina is much rarer. It accounts for 2% of all cases of angina. It is caused by vasospasm, but the mechanism of spasm is unknown but has been linked with hyperthyroidism in some studies. Patients with thyrotoxicosis-induced acute myocardial infarction are unusual and almost all reported cases have been associated with Graves' disease. Human chorionic gonadotropin hormone-induced hyperthyroidism occurs in about 1.4% of pregnant women, mostly when hCG levels are above 70–80 000 IU/L. Gestational transient thyrotoxicosis is transient and generally resolves spontaneously in the latter half of pregnancy, and specific antithyroid treatment is not required. Treatment with calcium channel blockers or nitrates reduces spasm in most of these patients. Overall, the prognosis for hyperthyroidism-associated coronary vasospasm is good. We describe a very rare case of an acute myocardial infarction in a 27-year-old female, at 9 weeks of gestation due to right coronary artery spasm secondary to gestational hyperthyroidism with free thyroxine of 7.7 ng/dL and TSH <0.07 IU/L.
Learning points:AMI and cardiac arrest due to GTT despite optimal medical therapy is extremely rare.
Gestational hyperthyroidism should be considered in pregnant patients presenting with ACS-like symptoms especially in the setting of hyperemesis gravidarum.
Our case highlights the need for increased awareness of general medical community that GTT can lead to significant cardiac events. Novel methods of controlling GTT as well as medical interventions like ICD need further study.
http://ift.tt/2fYoOIB
Hypersensitivity Reactions to Metallic Implants Containing Vanadium
No abstract availablehttp://ift.tt/2fX4Nii
Botanicals in Dermatology: Essential Oils, Botanical Allergens, and Current Regulatory Practices
Largely because of their perceived safety, the use of essential oils and other botanically derived products has become increasingly popular. Recent evidence raises concern about the safety of these products, frequently found in cosmetics and sought as an alternative to standard medical treatments. Essential oils are challenging to standardize because of the variable growing conditions, genetics, and harvesting of botanicals. There exists a potential for adverse reactions, in particular allergic contact dermatitis. Furthermore, these products are often sold without prior Food and Drug Administration approval of efficacy and safety. This review focuses on the composition of essential oils, their common associated botanical allergens, and current regulation practices of botanical drug products in the United States and Europe.http://ift.tt/2fX5Xu7
Essential Oils, Part V: Peppermint Oil, Lavender Oil, and Lemongrass Oil
Some aspects of peppermint oil, lavender oil, and lemongrass oil are discussed including their botanical origin, uses of the plants and the oils, chemical composition, contact allergy to and allergic contact dermatitis from these essential oils, and causative allergenic ingredients.http://ift.tt/2fX17wG
Allergic Contact Dermatitis to Ophthalmic Medications: Relevant Allergens and Alternative Testing Methods
Allergic contact dermatitis is an important cause of periorbital dermatitis. Topical ophthalmic agents are relevant sensitizers. Contact dermatitis to ophthalmic medications can be challenging to diagnose and manage given the numerous possible offending agents, including both active and inactive ingredients. Furthermore, a substantial body of literature reports false-negative patch test results to ophthalmic agents. Subsequently, numerous alternative testing methods have been described. This review outlines the periorbital manifestations, causative agents, and alternative testing methods of allergic contact dermatitis to ophthalmic medications.http://ift.tt/2fX2ziR
Epidemiology and Co-Reactivity of Novel Surfactant Allergens: A Double-Blind Randomized Controlled Study
Background: Surfactants are cleansing agents used in products such as shampoos and soaps. Objectives: The aims of this study were to identify positivity rates to 3 novel amide-containing surfactants (sodium lauroyl sarcosinate, isostearamidopropyl morpholine lactate, and disodium lauroamphodiacetate) and evaluate co-reactivity with other surfactants in patients with known surfactant sensitivity. Methods: Previously patch-tested, surfactant-positive patients were identified via chart review and invited to participate. Participants were patch tested to screening surfactants (cocamidopropyl betaine, amidoamine, dimethylaminopropylamine, cocamide diethanolamine [DEA], oleamidopropyl dimethylamine, and decyl glucoside), as well as 3 novel surfactants: sodium lauroyl sarcosinate 0.5% and 1.0% aq, isostearamidopropyl morpholine lactate 0.5% and 1.0% aq, disodium lauroamphodiacetate 1.0 and 2.0% aq, and a hypoallergenic liquid cleanser (tested semiopen). Participants and clinicians were blinded. The order of tested allergens was randomized. Results: Forty-seven participants completed the study. Excluding doubtful reactions, positive reactions were most common to oleamidopropyl dimethylamine (34%) and dimethylaminopropylamine (34%), followed by isostearamidopropyl morpholine lactate (23%). Reactivity was not associated with history of childhood eczema. Co-reactivity was high among oleamidopropyl dimethylamine, dimethylaminopropylamine, cocamidopropyl betaine, amidoamine, and isostearamidopropyl morpholine lactate. None of the participants who reacted to cocamide DEA reacted to an additional surfactant. Conclusions: Isostearamidopropyl morpholine lactate may be an important emerging allergen with sensitivity rates comparable with those of oleamidopropyl dimethylamine and dimethylaminopropylamine. Co-reactivity among surfactants was frequent except for cocamide DEA.http://ift.tt/2f5xEmO
Erythema Multiforme–Like Allergic Contact Dermatitis to Turmeric Essential Oil
No abstract availablehttp://ift.tt/2f5sp6E
Tolerance to a Hair Dye Product Containing 2-Methoxymethyl-P-Phenylenediamine in an Ethnically Diverse Population of P-Phenylenediamine-Allergic Individuals
Background: Allergic contact dermatitis after exposure to p-phenylenediamine (PPD)-containing hair dye products is a common and important clinical problem. Because there is a high rate of cross-elicitation of allergic contact dermatitis to other important hair dye products (such as p-toluene diamine and other aminophenol hair dyes) in PPD-allergic patients, safer alternative dyes with excellent hair coloring options are needed. Objective: This study aimed to study tolerance to Me-PPD in a PPD-allergic cohort. Methods: Twenty ethnically diverse volunteers with a history of contact dermatitis to hair dyes or other PPD-containing chemicals and positive patch test results to 1% PPD in petrolatum were recruited to study their immediate and delayed skin reactivity to PPD, vehicle control, and 2-methoxy-methyl-PPD (Me-PPD) using the allergy alert test (simulating hair dyeing conditions) on volar forearm skin. This test is a short-contact open patch test. Conclusions: The Me-PPD may offer a safer alternative for PPD-allergic patients with an absent or reduced elicitation response in the allergy alert test simulating hair dye use conditions. The absent or reduced response to Me-PPD diagnosed using the allergy alert test has been shown to help reduce the possibility of moderate to severe cross-elicitation reactions among consumers during hair dyeing.http://ift.tt/2f5xCeG
Disease Severity and Quality of Life Measurements in Contact Dermatitis: A Systematic Review 2005–2015
Background: Contact dermatitis (CD) has been assessed by numerous disease severity indices resulting in heterogeneity across published research. Objective: This study aims to evaluate published CD severity scales and identify a criterion standard for assessment. Methods: Scopus and Ovid MEDLINE were searched for human randomized controlled trials (RCTs) on CD severity measures published during a 10-year period. Eligible studies were English-language RCTs reporting disease severity outcome measures for CD in humans. Studies were excluded if they were duplicates, not available in English, not related to CD, not RCTs, not conducted on human subjects, or did not report relevant outcome measures. Results: A total of 22 disease outcome measures were used in 81 included RCTs. Instrument-based measures were used in 40 (49.4%) studies, and visual assessments were used in 66 (81.5%) RCTs. Only 5 (6.2%) studies reported quality of life (QoL) outcomes. Two (2.5%) studies used a clinical severity scale, which combined both QoL and visual assessments. Limitations: This study was limited by the exclusion of non-RCTs and gray literature. Conclusions: Wide variation in CD outcome measures exists including instrument-based measures, visual assessments, and QoL outcomes. A standardized outcome measure must be generated to reduce heterogeneity.http://ift.tt/2f5zGn5
The Scourge of the Spurge Family—An Imitator of Rhus Dermatitis
Abstract: The Euphorbiaceae family (commonly known as "spurge") is a large, diverse, and widely distributed family of plants that encompass around 300 genera and more than 8000 species. Their attractiveness and hearty nature have made them popular for both indoor ornamentation and outdoor landscaping. Despite their ubiquity, the potential to cause irritant contact dermatitis (ICD) is often overlooked in favor of more notorious causes of phytodermatitis, namely, Toxicodendron species and nettles. We examined case reports spanning 40 years and discovered that spurge-induced ICD tends to befall children and middle-aged adults who unwittingly encounter the plant through play or horticulture, respectively. Clinical presentation is pleomorphic. Erythema, edema, burning, vesicles, and pruritus of acute onset and rapid resolution are frequently observed. We present a classic case of ICD in a 12-year-old girl after exposure to Euphorbia myrsinites and review the literature on phytodermatitis caused by members of the Euphorbiaceae family.http://ift.tt/2fXaHQc
Risk factors for recurrent wheezing in the first year of life in the city of Córdoba, Argentina
Publication date: Available online 16 November 2016
Source:Allergologia et Immunopathologia
Author(s): A. Teijeiro, H. Badellino, M.G. Raiden, M.N. Cuello, G. Kevorkof, C. Gatti, V.H. Croce, D. Solé
BackgroundWheezing is a very common respiratory symptom in infants. The prevalence of wheezing in infants, conducted in developed countries shows prevalence rates ranging between 20% and 30%. However, we do not know the risk factors in our population of wheezing infants.MethodsA standardised written questionnaire (WQ-P1-EISL) in infants between 12 and 18 months of age residing in the city of Cordoba was used; population/sample included 1031 infants. Recurrent wheezing (RW) was defined as three or more episodes of wheezing reported by the parents during the first 12 months of life. Data obtained were coded in Epi-Info™ (version 7) and statistically analysed with SPSS (version 17.5) software in Spanish. Parametric tests (one-way ANOVA) were performed for identifying significantly associated variables.ResultsThe prevalence of wheezing infants was 39.7%; recurrent wheezing 33%; and severe wheezing 14.7%; 13.7% had pneumonia before the first year and of these 6.3% were hospitalised, multiple variables as risk factors for wheezing were found such as: >6 high airway infections and bronchiolitis in the first three months of life, smokers who smoke in the home among other risk factors and protective factors in those who have an elevated socioeconomic status.ConclusionIt is known that persistent respiratory problems in children due to low socioeconomic status is a risk factor for wheezing, pneumonia and could be a determining factor in the prevalence and severity of RW in infants. Research suggests that there are areas for improvement in the implementation of new educational strategies.
http://ift.tt/2eGY9Ad
Cisplatin-refraktäre Keimzelltumoren
Zusammenfassung
Hintergrund
Trotz der im Allgemeinen exzellenten Heilungsaussichten für Keimzelltumorpatienten sind Patienten mit Cisplatin-refraktärer Erkrankung weiterhin mit einer sehr ungünstigen Prognose konfrontiert.
Fragestellung
Der Beitrag vermittelt einen Überblick über Resistenzmechanismen, etablierte Therapieoptionen, mögliche therapeutische Zielstrukturen und aktuelle Entwicklungen neuer Therapieansätze.
Material und Methodik
Die Arbeit basiert auf einer umfassenden Literaturrecherche von Pubmed, MEDLINE und EMBASE aus den Jahren 1990–2016 sowie den Kongressbeiträgen der Jahrestagungen der ASCO und ESMO der Jahre 2013–2016.
Ergebnisse
Die Mechanismen einer Cisplatin-Resistenz sind vielschichtig. Bei primär Cisplatin-refraktärer Erkrankung, multiplen Rezidiven sowie nach Versagen einer Hochdosischemotherapie sind die Therapieoptionen stark limitiert und verfolgen oft keinen kurativen Ansatz mehr. Die Substanzen Gemcitabin, Oxaliplatin und Paclitaxel (GOP) sowie orales Etoposid stehen derzeit als wirksame Substanzen zur Verfügung. Hierbei vermag das GOP-Regime in Kombination mit einer sekundären Resektion aller Residuen bei selektierten Patienten sogar Langzeitremissionen zu erreichen. Zielgerichtete Therapeutika spielen bisher keine Rolle in der Therapie von Keimzelltumoren bei Männern.
Schlussfolgerungen
Cisplatin-refraktäre Keimzelltumoren stellen eine therapeutische Herausforderung dar und erfordern multimodale Therapiekonzepte an spezialisierten Zentren, um die Chance auf Langzeitremissionen zu wahren. Neue Therapieansätze, z. B. mit Cabazitaxel oder eine Blockade der PD-1/PD-L1-Achse sind Gegenstand aktueller klinischer Studien.
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Phase II Trial: uPAR-PET/CT for Prognostication in Head- and Neck Cancer
Intervention: Drug: 68Ga-NOTA-AE105
Sponsor: Rigshospitalet, Denmark
Recruiting - verified November 2016
http://ift.tt/2f58i8C
The Correlation Between Adenoid Hypertrophy and Body Temperature in Children Before and After Adenoidectomy
Intervention: Other: Temperature measurements
Sponsor: Hillel Yaffe Medical Center
Not yet recruiting - verified November 2016
http://ift.tt/2fWIgCf
Study of Concurrent Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma
Interventions: Drug: Docetaxel; Drug: Nedaplatin; Radiation: chest radiation
Sponsor: Sun Yat-sen University
Recruiting - verified November 2016
http://ift.tt/2f58B39
Adequately defining tumor cell proportion in tissue samples for molecular testing improves interobserver reproducibility of its assessment
Abstract
Gene mutation status assessment of tumors has become standard practice in diagnostic pathology. This is done using samples comprising tumor cells but also non-tumor cells, which may dramatically dilute the proportion of tumor DNA and induce false negative results. Increasing sensitivity of molecular tests presently allows detection of a targeted mutation in a sample with a small percentage of tumor cells, but assessment of tumor cellularity remains essential to adequately interpret the results of molecular tests. Comprehensive tumor cell counting would provide the most reliable approach but is time consuming, and therefore rough global estimations are used, the reliability of which has been questioned in view of their potential clinical impact. The French association for quality assurance in pathology (AFAQAP) conducted two external quality assurance schemes, partly in partnership with the French group of oncology cytogenomics (GFCO). The purpose of the schemes was to (1) evaluate how tumor cellularity is assessed on tissue samples, (2) identify reasons for discrepancies, and (3) provide recommendations for standardization and improvement. Tumor cell percentages in tissue samples of lung and colon cancer were estimated by 40–50 participants, on 10 H&E virtual slides and 20 H&E conventional slides. The average difference between lowest and highest estimated percentage was 66. This was largely due to inadequate definition of cellularity, reflecting confusion between the percentage of tumor cells and the percentage of the area occupied by tumor in the assessed region. The widest range of interobserver variation was observed for samples with dense or scattered lymphocytic infiltrates or with mucinous stroma. Estimations were more accurate in cases with a low percentage of tumor cells. Macrodissection of the most homogeneous area in the tissue reduced inter-laboratory variation. We developed a rating system indicating potential clinical impact of a discrepancy. Fewer discrepancies were clinically relevant since the study was conducted. Although semi-quantitative estimations remain somewhat subjective, their reliability improves when tumor cellularity is adequately defined and heterogeneous tissue samples are macrodissected for molecular analysis.
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One-and-a-half nostril endoscopic transsphenoidal approach for pituitary adenomas—a technical report
Binostril endoscopic transsphenoidal approach (BETA) provides sufficient manipulation space and wide endoscopic vision, although it increases the trauma of nose. Mononostril endoscopic transsphenoidal approach...
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