Comparative clinical study of gabapentin and pregabalin for postoperative analgesia in laparoscopic cholecystectomy
Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 5 δευτερόλεπτα
*Rajshree Mishra, Manoj Tripathi, HC Chandola* Anesthesia: Essays and Researches 2016 10(2):201-206 Background: Reduction in central sensitization by gabapentinoids that include gabapentin and pregabalin may reduce acute postoperative pain. Aims: The aim of this study is to evaluate postoperative analgesic benefit and efficacy in patients administered with oral gabapentin or pregabalin as premedication for laparoscopic cholecystectomy under general anesthesia. Settings and Design: Randomized, prospective, and comparative study. Materials and Methods: In this study, recruited patient...περισσότερα »
Prospective randomized study to compare between intravenous dexmedetomidine and esmolol for attenuation of hemodynamic response to endotracheal intubation
Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 5 δευτερόλεπτα
*Venkatesh Selvaraj, Karthik Raj Manoharan* Anesthesia: Essays and Researches 2016 10(2):343-348 Background: Esmolol has an established role in attenuation of hemodynamic response to laryngoscopy and endotracheal intubation. We studied the effect of dexmedetomidine compared to that of esmolol in this study. Aim: To study the role of dexmedetomidine in attenuation of hemodynamic response to laryngoscopy and oral endotracheal intubation compared to that of esmolol hydrochloride in patients posted for elective surgery under general anesthesia. Study Design: Prospective randomized study... περισσότερα »
Influence of two anesthetic techniques on blood sugar level in head injury patients: A comparative study
Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 5 δευτερόλεπτα
*Manoj Kumar, Manoj Tripathi, Deepak Malviya, PS Malviya, Virendra Kumar, Amit Tyagi* Anesthesia: Essays and Researches 2016 10(2):207-211 Background: Head injury presents a major worldwide social, economic, and health problem. Hyperglycemia is a significant indicator of the severity of injury and predictor of outcome, which can easily be prevented. There has been a long-standing controversy regarding the use of inhalational or intravenous (i.v.) anesthetic agents for surgery of head injury cases and impact of these agents on blood sugar level. Aims and Objectives: The aim of this ...περισσότερα »
Recurarization in a successfully managed case of posterior reversible encephalopathy syndrome (PRES) for emergency caesarean section
Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 5 δευτερόλεπτα
*Suchita Parikh, Snehlata Tavri, Shubha Mohite* Anesthesia: Essays and Researches 2016 10(2):370-372 Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiologic syndrome of headache, visual changes, altered mental status and seizures with radiologic findings of posterior cerebral white matter edema. It is seen in hypertensive encephalopathy, renal failure, and autoimmune disorders or in patients on immunosuppressants. We report a case of 24-year-old primigravida who presented at term with sudden onset hypertension, neurological deficits, and an episode of the visual b... περισσότερα »
Postanesthetic shivering (PAS)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Postanesthetic shivering From Wikipedia, the free encyclopedia Postanesthetic shivering Classification and external resources *Postanesthetic shivering* (PAS) is shivering after anesthesia.[1] The intensity of PAS may be graded using the scale described by Crossley and Mahajan: 0 = no shivering;1 = no visible muscle activity but piloerection, peripheral vasoconstriction, or both are present (other causes excluded);2 = muscular activity in only one muscle group;3 = moderate muscular activity in more than one muscle group but no generalized shaking;4 = violent muscular activity that inv...περισσότερα »
Role of butorphanol and ondansetron premedication in reducing postoperative shivering
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Role of butorphanol and ondansetron premedication in reducing postoperative shivering *Sujeet Rai, Satyajeet Verma, HP Pandey, Pramod Yadav, Amit Patel* Anesthesia: Essays and Researches 2016 10(2):319-323 Background: Postoperative shivering (PAS) is a common problem following general and spinal anesthesia and may lead to multiple complications. This placebo-controlled, randomized study was performed to evaluate the efficacy of Ondansetron and butorphanol premedication reduces shivering after general and spinal anaesthesia. Aims: The aim of this study to highlight the effica... περισσότερα »
Peroral endoscopic myotomy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
—initial experience with anesthetic management of 24 procedures and systematic review: *Basavana Goudra, Preet Mohinder Singh, Gowri Gouda, Ashish C Sinha* Anesthesia: Essays and Researches 2016 10(2):297-300 Background: Peroral endoscopic myotomy (POEM) is a novel method of treating achalasia of the esophagus. Very little data are available to guide the anesthesia providers caring for these patients. The anesthetic challenges are primarily related to the risk of pulmonary aspiration. There is also a potential risk of pneumomediastinum, pneumoperitoneum, subcutaneous, or submuc... περισσότερα »
The pharyngolaryngeal morbidity of laryngeal mask airway versus endotracheal tube
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
A randomized control study comparing *A Venugopal, Ron Mathew Jacob, Rachel Cherian Koshy* Anesthesia: Essays and Researches 2016 10(2):189-194 Introduction: Endotracheal tube (ETT) has been associated with various pharyngolaryngeal morbidities (PLMs) following general anesthesia (GA). Laryngeal mask airway (LMA), currently the most commonly used supraglottic airway device, has several advantageous over the ETT but has been associated with varying results of PLM. The aim of our study was to compare the PLM between them and to know whether LMA is a better alternative. Materia...περισσότερα »
Anesthetic efficacy of 4% articaine versus 2% lignocaine
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
during the surgical removal of the third molar: A comparative prospective study: *Nikil Kumar Jain, Reena Rachel John* Anesthesia: Essays and Researches 2016 10(2):356-361 Aim: The study aimed at evaluating the clinical efficacy of articaine over lidocaine in the surgical removal of impacted mandibular third molars. Objective: The objectives were to compare the onset of anesthesia, pain during injection, during the procedure and after the procedure, compare the duration of anesthesia, and need for re-anesthesia. Materials and Methods: A prospective study was conducted on 70 sub...περισσότερα »
Regional anesthesia in difficult airway
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
The quest for a solution continues: *Ranjana Khetarpal, Veena Chatrath, Akshay Dhawan, Joginder Pal Attri* Anesthesia: Essays and Researches 2016 10(2):178-183 Difficult airway, a scenario with potentially life threatening outcome, is routinely encountered by an anesthesiologist leaving him with the dilemma of whether to use regional anesthesia (RA) or general anesthesia. Our study aims to look into this problem. The literature search was performed in the Google, PubMed, and Medscape using key words “regional anesthesia, difficult airway, pregnancy, ventilation, intubation, epid... περισσότερα »
Seizures associated with low-dose tramadol for chronic pain treatment
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Seizures associated with low-dose tramadol for chronic pain treatment: *Serbülent Gökhan Beyaz, Tuğba Sonbahar, Fikret Bayar, Ali Fuat Erdem* Anesthesia: Essays and Researches 2016 10(2):376-378 The management of cancer pain still poses a major challenge for clinicians. Tramadol is a centrally acting synthetic opioid analgesic. Its well-known side effects include nausea, vomiting, and dizziness; seizures are a rare side effect. Some reports have found that tramadol triggers seizure activity at high doses, whereas a few preclinical studies have found that this seizure activity is... περισσότερα »
Delayed recovery from anesthesia
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
A postgraduate educational review: *Ullhas Sudhakarrao Misal, Suchita Annasaheb Joshi, Mudassir Mohd Shaikh* Anesthesia: Essays and Researches 2016 10(2):164-172 Delayed awakening from anesthesia remains one of the biggest challenges that involve an anesthesiologist. With the general use of fast-acting anesthetic agents, patients usually awaken quickly in the postoperative period. The time to emerge from anesthesia is affected by patient factors, anesthetic factors, duration of surgery, and painful stimulation. The principal factors responsible for delayed awakening following an...περισσότερα »
Sevoflurane in low-flow anesthesia using “equilibration point”
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Sevoflurane in low-flow anesthesia using “equilibration point”: *Veena Chatrath, Ranjana Khetarpal, Divya Bansal, Harjinder Kaur* Anesthesia: Essays and Researches 2016 10(2):284-290 Context: While giving low-flow anesthesia, it is a routine practice to give fixed duration of initial high-flow. This study was conducted to show the use of equilibration point as changeover point from initial high-flow to low-flow. Aims: It was to compare the use of equilibration point, hemodynamics, end-tidal agent concentration, recovery time, and recovery score between isoflurane and sevofluran... περισσότερα »
Site-specific DNA methylation changes with cow’s milk allergy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Epigenome-wide association study links via Allergy and Clinical Immunology Publication date: Available online 25 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Xiumei Hong, Christine Ladd-Acosta, Ke Hao, Ben Sherwood, Hongkai Ji, Corinne A. Keet, Rajesh Kumar, Deanna Caruso, Xin Liu, Guoying Wang, Zhu Chen, Yuelong Ji, Guanyun Mao, Sheila Ohlsson Walker, Tami R. Bartell, Zhicheng Ji, Yifei Sun, Hui-Ju Tsai, Jacqueline A. Pongracic, Daniel E. Weeks, Xiaobin Wang We demonstrates that DNA methylation alterations at multiple genes, including those in the TH1-TH2... περισσότερα »
Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
by dampening anti-viral immunity via Allergy and Clinical Immunology Publication date: Available online 25 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Jason P. Lynch, Rhiannon B. Werder, Jennifer Simpson, Zhixuan Loh, Vivian Zhang, Ashraful Haque, Kirsten Spann, Peter D. Sly, Stuart B. Mazzone, John W. Upham, Simon Phipps BackgroundFrequent viral lower respiratory infections in early-life are an independent risk factor for asthma onset. This risk, and the development of persistent asthma, is significantly greater in children who later become sensitized.Ob...περισσότερα »
Fish oil supplementation during pregnancy and allergic respiratory disease
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
in the adult offspring via Allergy and Clinical Immunology Publication date: Available online 25 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Susanne Hansen, Marin Strøm, Ekaterina Maslova, Ronald Dahl, Hans Jürgen Hoffmann, Dorte Rytter, Bodil Hammer Bech, Tine Brink Henriksen, Charlotta Granström, Thorhallur I. Halldorsson, Jorge E. Chavarro, Allan Linneberg, Sjurdur F. Olsen BackgroundMaternal supplementation with long chain n-3 polyunsaturated fatty acids (PUFAs) may have immunological effects on the developing fetus through several anti-inflammatory p... περισσότερα »
The canalis sinuosus (CS) between the incisive foramen and the anterior maxillary alveolar ridge
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Location and classification of Canalis sinuosus for cone beam computed tomography: avoiding misdiagnosis: Abstract The aim of this study was to assess the presence, location and, multiplanar distance of the canalis sinuosus (CS) between the incisive foramen and the anterior maxillary alveolar ridge using cone beam computed tomography (CBCT). Therefore, 500 CBCT maxillary images obtained from male and female patients aged 20 to 80 years were selected to assist in the dental treatment. Low-quality tomographic images were discarded. All images were captured with the i-CATTM Classic tom...περισσότερα »
Age-related changes in the woman’s smile
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Brazilian woman’s smile: Abstract The aim of this research was to evaluate age-related changes in the smile of Brazilian women. The sample consisted of 249 Brazilian women who had not undergone previous orthodontic treatment or facial surgery. They were divided into four groups, according to age: G1 (20-29), G2 (30-39), G3 (40-49) and G4 (50 or older). Standardized front view photographs were taken while smiling and at rest. Measurements were evaluated by ANOVA and post-hoc Tukey. The Chi-square test was applied for qualitative variables. Upper lip thickness at rest and exposure of u...περισσότερα »
Oral and craniofacial manifestations of Ellis-van Creveld syndrome
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Article in Press : Case series - Full Text - Images - References - PDF (754 KB) - Download Images(.ppt)About Images & Usage - Email Article - Add to My Reading List - Export Citation - Create Citation Alert - Cited by in Scopus (0) Elif Bahar Tuna , Mine Koruyucu , Esma Kürklü, DDS, Ph.D.[image: correspondence][image: email] , Muhsin Çifter , Koray Gençay , Figen Seymen , Beyhan Tüysüz *Journal of Craniomaxillofacial Surgery* Received: January 9, 2015; Received in revised form: March 21, 2016; Accepted: April 15, 2016; Published Online: April 26, 2... περισσότερα »
Microvascular reconstruction of the tongue using a free anterolateral thigh flap
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Article in Press Microvascular reconstruction of the tongue using a free anterolateral thigh flap: Three-dimensional evaluation of volume loss after radiotherapy - Full Text - Images - References - PDF (1 MB) - Download Images(.ppt)About Images & Usage - Email Article - Add to My Reading List - Export Citation - Create Citation Alert - Cited by in Scopus (0) Achille Tarsitano, MD, FEBOMS[image: correspondence][image: email][image: email] , Salvatore Battaglia, MD , Riccardo Cipriani, MD (Head Dr.) , Claudio Marchetti, MD, DDS (Head Prof.) *Journal of ... περισσότερα »
Postoperative delirium
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
Article in Press Incidence and risk factors for postoperative delirium after major head and neck cancer surgery - Full Text - Images - References - PDF (888 KB) - Download Images(.ppt)About Images & Usage - Email Article - Add to My Reading List - Export Citation - Create Citation Alert - Cited by in Scopus (0) Eisuke Booka, MD, PhD , Tomoyuki Kamijo, MD, PhD[image: correspondence][image: email] , Teruaki Matsumoto, MD , Mari Takeuchi, MD, PhD , Takashi Kitani, MD , Masato Nagaoka, MD, PhD , Atsushi Imai, MD, PhD , Yoshiyuki Iida, MD , Ayako Shim... περισσότερα »
Predictors of free flap loss in the head and neck region
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
a four-year retrospective study with 451 microvascular transplants at a single centre: Microvascular free flaps have become an essential part of reconstructive surgery following head and neck tumour ablation. The authors’ aim was to investigate the influence of cardiovascular risk factors, preoperative irradiation, previous operations and metabolically active medication on free flap loss in order to predict patients at risk and to improve their therapy. AbstractIntroduction Microvascular free flaps have become an essential part of reconstructive surgery following head and neck tu... περισσότερα »
Effect of fronto-orbital advancement on astigmatism in patients with anterior plagiocephaly
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Article in Press Effect of fronto-orbital advancement on astigmatism in patients with anterior plagiocephaly - Full Text - References - Supplemental Materials - PDF (568 KB) - Email Article - Add to My Reading List - Export Citation - Create Citation Alert - Cited by in Scopus (0) Hyun Beom Song, M.D.1 , Hee Kyung Yang, M.D.1 , Rong-Min Baek, M.D. , Jeong-Min Hwang, M.D.[image: correspondence][image: email] , Namju Kim, M.D. , Kyu-Chang Wang, M.D. , Sukwha Kim, M.D. 1The first two authors contributed equally to this work. *Journal of Craniomaxillofacia... περισσότερα »
Extensive oral mucosal hyperkeratosis caused by over-the-counter long lasting snoring relief agent
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Response to letter Re: We are writing with regard to the letter from a representative of the manufacturer of the snoring relief agent Snoreeze,1 which was sent in response to our recent publication “Extensive oral mucosal hyperkeratosis caused by over-the-counter long lasting snoring relief agent”.2
Transoral Segmental Resection and Disarticulation of Mandible with Immediate Nonvascularized Reconstruction
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
A Case Report: Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0036-1582456 Disarticulation resections are required for treatment of variety of pathologies of the jaws. These resections are mostly carried out through extraoral approach, which bear significant postoperative morbidity. The transoral approach may be used for this purpose in benign pathological cases of the mandible to limit the postoperative morbidity of extraoral approach, as it provides sufficient access not only for resection and disarticulation but also for immediate reconstruction. This article shares o... περισσότερα »
The Clinical Management of Chronic Pain
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
The Role of Resilience in AbstractChronic pain affects more individuals than does cancer, heart disease, and diabetes combined. Yet, our treatment options remain remarkably limited. Often, highly effective psychotherapeutic approaches are limited by many barriers such as access, reimbursement, and acceptability; however, resilience-based positive activity interventions could offer a promising alternative. These interventions are engaging, non-stigmatizing, and do not require a mental health professional for their provision. This article reviews the new, but limited, research explor... περισσότερα »
Molecular Systems Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Molecular Systems Biology, published by European Molecular Biology Organization, last updated on 2016-04-26, available at http://ift.tt/1lNUn1h from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lNUn1h via IFTTT
Histone modifications interact with DNA methylation at the GATA4 promoter during differentiation of mesenchymal stem cells into cardiomyocyte-like cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Abstract Objectives A previous study of ours confirmed that Islet-1 specifically induces differentiation of MSCs into cardiomyocytes, and that one of the mechanisms underlying that process is regulation of histone acetylation. Here, we further explore the mechanism of MSC differentiation into cardiomyocytes from the perspective of interactions between epigenetic modifications. Materials and methods We used […]
Sphingosine-1-Phosphate Signaling in Endothelial Disorders
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Abstract Numerous preclinical studies indicate that sustained endothelial activation significantly contributes to tissue edema, perpetuates the inflammatory response, and exacerbates tissue injury ultimately resulting in organ failure. However, no specific therapies aimed at restoring endothelial function are available as yet. Sphingosine-1-phosphate (S1P) is emerging as a potent modulator of endothelial function and endothelial responses to […]
Myocardial Viability and Revascularization: Current Understanding and Future Directions
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Abstract The initial observation of functional recovery in dysfunctional myocardium following revascularization led to the introduction of the concept of hibernating myocardium. Since then, the pathophysiologic basis of hibernating myocardium has been well described. Multiple imaging modalities have been utilized to prospectively detect viable myocardium and thus predict its functional recovery following revascularization. It has […]
Dynamic Contrast-Enhanced MRI to Study Atherosclerotic Plaque Microvasculature
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Abstract Rupture of a vulnerable atherosclerotic plaque of the carotid artery is an important underlying cause of clinical ischemic events, such as stroke. Abundant microvasculature has been identified as an important aspect contributing to plaque vulnerability. Plaque microvasculature can be studied non-invasively with dynamic contrast-enhanced (DCE-)MRI in animals and patients. In recent years, several DCE-MRI […]
Migraine and incidence of ischemic stroke: A nationwide population-based study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Background The association between migraine and the incidence of ischemic stroke varies in different subgroups of patients. We aimed to clarify this association using a population-based database. Method A nationwide cohort study was conducted using data from the Taiwan National Health Insurance Research Database. Two cohorts were extracted: a neurologist-diagnosed migraine cohort, and a non-headache, […]
Botox
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Botox: A highly purified preparation of botulinum toxin A, a toxin produced by the bacterium Clostridium botulinum. Botox is injected, in very small amounts, into specific muscles, as a treatment. It acts by blocking the transmission of nerve impulses to muscles and so paralyzes (relaxes) the muscles. Botox treatment has found a growing number of […]
Anticancer berberine mixed micelles
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Shen R, Kim JJ, Yao M, Elbayoumi TA from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21eOQFY via IFTTT
Response of neural stem cells to SPION exposure
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Pongrac IM, Pavičić I, Milić M, Brkić Ahmed L, Babič M, Horák D, Vinković Vrček I, Gajović S from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UgbTiB via IFTTT
First clinical cases of NDM-1-producing Klebsiella pneumoniae from two hospitals in Bulgaria
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Publication date: Available online 26 April 2016 Source:Journal of Infection and Chemotherapy Author(s): Bozhana Todorova, Stefana Sabtcheva, Ivan N. Ivanov, Magdalena Lesseva, Tzano Chalashkanov, Magda Ioneva, Assya Bachvarova, Elina Dobreva, Todor Kantardjiev We report the first confirmed cases of NDM-1-producing Klebsiella pneumoniae infections in two hospitals in Bulgaria. The isolates were diverse in terms of […]
B-Cell Lymphoma as a Large Isolated Epiglottic Mass
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
Case Report and Literature Review: Extranodal presentation of B-cell lymphoma is uncommon. Isolated primary epiglottic B-cell lymphoma is even rarer. To our knowledge, there has been only one description of isolated B-cell lymphoma presenting as a large epiglottic mass. We report an unusual type of B-cell lymphoma of the epiglottis, as it could not be subtyped based on routine staining and hybridization. The lymphoma presented as a large isolated globular mass pedicled to the epiglottis, occupying most of the oropharynx, but did not have any ball-valving effect or increased respirat... περισσότερα »
Oral lichen planus clinical characteristics
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
in Italian patients: a retrospective analysis: Abstract BackgroundOral lichen Planus (OLP) is a chronic inflammatory disease involving skin and mucous membranes. Its etiology is still uncertain whilst an autoimmune mechanism is known to be implicated. OLP is commonly considered a geriatric disease and gender differences in prevalence are clear, whereby females are generally more frequently affected than males more often during the 5th and 6th decades of life. Lesions are symmetrical and bilateral and the buccal mucosa is frequently involved. The risk of malignant transformation i...περισσότερα »
Drug delivery system of basic fibroblast growth factor using gelatin hydrogel for restoration of acute vocal fold scar
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
Drug delivery system of basic fibroblast growth factor using gelatin hydrogel for restoration of acute vocal fold scar: There continue to be therapeutic challenges in the management of vocal fold scarring. We previously showed that basic fibroblast growth factor (bFGF) injection has therapeutic potential for vocal fold scarring. However, the working time of bFGF is relatively short, and multiple injections were required in many cases to obtain the regenerative effect. An efficacious delivery system for bFGF has yet to be established. We designed a method of sustained drug delivery s... περισσότερα »
In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
in the chick chorioallantoic model: Abstract Background Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with poor overall survival. New therapeutic strategies that target specific molecular lesions driving advanced disease are needed. Herein we demonstrate the utility of the chicken chorioallantoic membrane (CAM) assay for in vivo human HNSCC tumor growth and metastasis and the tumor suppressive effects of a new chemotherapeutic agent. Methods We tested anti-metastatic effects of a WNT pathway inhibitor, WNT974 (also known as LGK974), which targets ...περισσότερα »
Angioedema Phenotypes: Disease Expression and Classification
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract Due to marked heterogeneity of clinical presentations, comprehensive knowledge of angioedema phenotypes is crucial for correct diagnosis and choosing the appropriate therapeutic approach. One of the ways to a meaningful clinical distinction can be made between forms of angioedema occurring “with or without wheals.” Angioedema with wheals (rash) is a hallmark of urticaria, either […]
Genetics of Hereditary Angioedema Revisited
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract Contemporary genetic research has provided evidences that angioedema represents a diverse family of disorders related to kinin metabolism, with a much greater genetic complexity than was initially considered. Convincing data have also recently been published indicating that the clinical heterogeneity of hereditary angioedema due to C1 inhibitor deficiency (classified as C1-INH-HAE) could be attributed […]
Human IgE-independent systemic anaphylaxis
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Anaphylaxis is a rapidly developing, life-threatening, generalized or systemic allergic reaction that is classically elicited by antigen crosslinking of antigen-specific IgE bound to the high-affinity IgE receptor FcεRI on mast cells and basophils. This initiates signals that induce cellular degranulation with release and secretion of vasoactive mediators, enzymes, and cytokines. However, IgE-independent mechanisms of anaphylaxis […]
The Role of IgE in Autoimmunity
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
There is accumulating evidence to suggest that IgE plays a significant role in autoimmunity. The presence of circulating self-reactive IgE in patients with autoimmune disorders has been long known, but at the same time largely understudied. Studies have shown, however, that the increased IgE concentration is not associated with higher prevalence for atopy and allergy […]
Anaphylactic reactions associated with omalizumab administration: Analysis of a case-control study
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
The risk for anaphylactic reactions to omalizumab is greatest in patients with histories of anaphylaxis unrelated to omalizumab and in those with food allergies. Anaphylaxis to omalizumab does not appear to be IgE antibody mediated. from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24iBMkF via IFTTT
IgG subclasses determine pathways of anaphylaxis in mice
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Antibodies of the IgG class can contribute to anaphylaxis. This report reveals pathways induced by each IgG subclass in experimental anaphylaxis, demonstrating varying contributions of cells, mediators and antibody receptors. from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1MXFmMO via IFTTT
CD151, a laminin receptor showing increased expression in asthma, contributes to airway hyperresponsiveness through calcium signaling
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
CD151 expression is increased in human subjects with asthma and its expression impacts on allergen-induced AHR in vivo, supporting a clinically relevant role, and the need to investigate further its contribution in the pathophysiology of allergic asthma. from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24iBKcz via IFTTT
Oral Oncology
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Considering the survivorship care needs of head and neck cancer survivors by Dennis Abbott, Ezra Cohen, Nader Sadeghi, Kevin Stein, Nicole Erb via Oral Oncology The American Cancer Society Head and Neck Cancer Survivorship Care Guideline was recently published in CA: A Cancer Journal for Clinicians. This synthesis of systematic literature review and consensus opinion from a multidisciplinary expert workgroup represents the fourth in a series of cancer site-specific adult post-treatment cancer survivorship care guidelines, with other guidelines addressing breast, colorectal, and prost... περισσότερα »
Marketing von Gesundheitsleistungen in Hals-, Nasen-, Ohrenkliniken
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Marketing von Gesundheitsleistungen in Hals-, Nasen-, Ohrenkliniken: Laryngo-Rhino-Otol DOI: 10.1055/s-0041-110060 Hintergrund: Die Erbringung von Gesundheitsleistungen basiert in Deutschland auf einer solidarischen Grundprämisse und ist hochreglementiert. Es stellt sich die Frage nach den Optionen für ein Marketing von Gesundheitsleistungen in Hals-, Nasen-, Ohrenkliniken. Material und Methoden: Die Marketingoptionen werden mithilfe umweltanalytischer Betrachtungen eruiert. Ergebnisse: Das Erreichen der unternehmensgerichteten oder kundengerichteten Marketingziele kann mit Maßnah...περισσότερα »
Delayed Diagnosis, Leprosy Reactions, and Nerve Injury Among Individuals With Hansen’s Disease Seen at a United States Clinic
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Background. Hansen’s disease (HD), or leprosy, is uncommon in the United States. We sought to describe the characteristics of patients with HD in a US clinic, including an assessment of delays in diagnosis and HD reactions, which have both been associated with nerve damage. Methods. A retrospective chart review was conducted on patients seen at […]
DTC : Significance of Low Levels of Thyroglobulin Autoantibodies
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Associated with Undetectable Thyroglobulin After Thyroidectomy for Differentiated Thyroid Carcinoma: [image: access_free.gif] Thyroid , Vol. 0, No. 0. Author information Francesco Latrofa,1Debora Ricci,1 Eleonora Sisti,1 Paolo Piaggi,2 Chiara Nencetti,1 Michele Marinò,1and Paolo Vitti1 1Endocrinology Unit I, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy. 2Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona. Address corresp... περισσότερα »
The Amsterdam Inventory for Auditory Disability and Handicap Using Item Response Theory
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα
Reevaluation of Purpose We reevaluated the psychometric properties of the Amsterdam Inventory for Auditory Disability and Handicap (AIADH; Kramer, Kapteyn, Festen, & Tobi, 1995) using item response theory. Item response theory describes item functioning along an ability continuum. Method Cross-sectional data from 2,352 adults with and without hearing impairment, ages 18–70 years, were analyzed. They completed the AIADH in the web-based prospective cohort study “Netherlands Longitudinal Study on Hearing.” A graded response model was fitted to the AIADH data. Category response cu... περισσότερα »
The Cost of Ménière’s Disease
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα
A Novel Multisource Approach: [image: image] Objectives: To estimate the annual cost of Ménière’s disease and the cost per person in the UK population and to investigate the direct and indirect costs of the condition. Design: The authors utilized a multidata approach to provide the first estimate of the cost of Ménière’s. Data from the UK Biobank (a study of 500,000 individuals collected between 2007 and 2012), the Hospital Episode Statistics (data on all hospital admissions in England from 2008 to 2012) and the UK Ménière’s Society (2014) were used to estimate the cost of Ménièr... περισσότερα »
Masked Speech Perception Thresholds
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα
in Infants, Children, and Adults: [image: image]Objective: The primary goal of this study was to compare infants’ susceptibility to making produced by a two-talker speech and a speech-shaped noise masker. It is well documented that school-age children experience more difficulty recognizing speech embedded in two-talker speech than spectrally matched noise, a result attributed to immaturity in the ability to segregate target from masker speech, and/or to selectively attend to the target while disregarding the perceptually similar speech masker. However, findings from infant psychoph... περισσότερα »
Monothermal Caloric Screening to Improve Healthcare Value
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα
Monothermal Caloric Screening to Improve Healthcare Value: [image: image]Objectives: To evaluate whether monothermal caloric screening can reduce the number of caloric irrigations required in the vestibular testing battery while maintaining diagnostic accuracy. Design: Prospective controlled cohort study. Three hundred and ninety patients referred for vestibular testing at this tertiary referral health system over a 1-year period were evaluated; 24 patients met exclusion or failure criteria and 366 patients were included in the study. Population was 35.6% male; average age was 50.4 ... περισσότερα »
Salivary Cortisol Profiles of Children with Hearing Loss
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα
Salivary Cortisol Profiles of Children with Hearing Loss: Objectives: It has long been speculated that effortful listening places children with hearing loss at risk for fatigue. School-age children with hearing loss experiencing cumulative stress and listening fatigue on a daily basis might undergo dysregulation of hypothalamic–pituitary–adrenal (HPA) axis activity resulting in elevated or flattened cortisol profiles. The purpose of this study was to examine whether school-age children with hearing loss show different diurnal salivary cortisol patterns than children with normal hea... περισσότερα »
Cortical Activation Patterns Correlate with Speech Understanding
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
After Cochlear Implantation: Objectives: Cochlear implants are a standard therapy for deafness, yet the ability of implanted patients to understand speech varies widely. To better understand this variability in outcomes, the authors used functional near-infrared spectroscopy to image activity within regions of the auditory cortex and compare the results to behavioral measures of speech perception. Design: The authors studied 32 deaf adults hearing through cochlear implants and 35 normal-hearing controls. The authors used functional near-infrared spectroscopy to measure responses wi... περισσότερα »
Description of Adults Seeking Hearing Help
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
for the First Time According to Two Health Behavior Change Approaches: Transtheoretical Model (Stages of Change) and Health Belief Model: Objectives: Several models of health behavior change are commonly used in health psychology. This study applied the constructs delineated by two models—the transtheoretical model (in which readiness for health behavior change can be described with the stages of precontemplation, contemplation and action) and the health belief model (in which susceptibility, severity, benefits, barriers, self-efficacy, and cues to action are thought to determine l... περισσότερα »
A Binaural Cochlear Implant Sound Coding Strategy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Inspired by the Contralateral Medial Olivocochlear Reflex: [image: image] Objectives: In natural hearing, cochlear mechanical compression is dynamically adjusted via the efferent medial olivocochlear reflex (MOCR). These adjustments probably help understanding speech in noisy environments and are not available to the users of current cochlear implants (CIs). The aims of the present study are to: (1) present a binaural CI sound processing strategy inspired by the control of cochlear compression provided by the contralateral MOCR in natural hearing; and (2) assess the benefits of th...περισσότερα »
The Use of the Kurtosis-Adjusted Cumulative Noise Exposure Metric
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Evaluating the Hearing Loss Risk for Complex Noise: [image: image] Objective: To test a kurtosis-adjusted cumulative noise exposure (CNE) metric for use in evaluating the risk of hearing loss among workers exposed to industrial noises. Specifically, to evaluate whether the kurtosis-adjusted CNE (1) provides a better association with observed industrial noise-induced hearing loss, and (2) provides a single metric applicable to both complex (non-Gaussian [non-G]) and continuous or steady state (Gaussian [G]) noise exposures for predicting noise-induced hearing loss (dose–response cur... περισσότερα »
Frequency–Amplitude Ratio of Ocular Vestibular-Evoked Myogenic Potentials for Detecting Meniere’s Disease
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
: A Preliminary Investigation: [image: image] Objective: Several parameters of ocular vestibular-evoked myogenic potential (oVEMP) have been used to identify Meniere’s disease. Nonetheless frequency–amplitude ratio (FAR), which is the ratio of amplitude between two frequencies, is one among the parameters that has failed to attract researchers’ attention despite proving its worth in diagnosis of Meniere’s disease when used in conjunction with cervical VEMP. Thus, the present study aimed at investigating the utility of FAR of oVEMP in identifying Meniere’s disease and finding out an... περισσότερα »
Effects of Threshold Adjustment on Speech Perception
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
in Nucleus Cochlear Implant Recipients: Objective: The objective of this study was to investigate the impact of using smaller and larger electric dynamic ranges on speech perception, aided thresholds, and subjective preference in cochlear implant (CI) subjects with the Nucleus® device. Design: Data were collected from 19 adults using the Nucleus CI system. Current levels (CLs) used to set threshold stimulation levels (T-levels) were set above or below the measured hearing thresholds to create smaller or larger electric output dynamic ranges, respectively, whereas the upper stimulat... περισσότερα »
Having Two Ears Facilitates the Perceptual Separation of Concurrent Talkers
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
for Bilateral and Single-Sided Deaf Cochlear Implantees: Objectives: Listening to speech with multiple competing talkers requires the perceptual separation of the target voice from the interfering background. Normal-hearing listeners are able to take advantage of perceived differences in the spatial locations of competing sound sources to facilitate this process. Previous research suggests that bilateral (BI) cochlear-implant (CI) listeners cannot do so, and it is unknown whether single-sided deaf (SSD) CI users (one acoustic and one CI ear) have this ability. This study investigat... περισσότερα »
Diabetes-Associated Changes in Cortical Auditory-Evoked Potentials
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
in Relation to Normal Aging: [image: image] Objectives: (1) To characterize the influence of type 2 diabetes mellitus (DM) on cortical auditory-evoked potentials (CAEPs) separate from the effects of normal aging, and (2) to determine whether the disease-related effects are modified by insulin dependence. Design: A cross-sectional study was conducted in a large cohort of Veterans to investigate the relationships among type 2 DM, age, and CAEPs in randomly selected participants with (N = 108) and without (N = 114) the disease and who had no more than a moderate hearing loss. Partici... περισσότερα »
The Effects of Acoustic Bandwidth
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
on Simulated Bimodal Benefit in Children and Adults with Normal Hearing: Objectives: The primary purpose of this study was to examine the effect of acoustic bandwidth on bimodal benefit for speech recognition in normal-hearing children with a cochlear implant (CI) simulation in one ear and low-pass filtered stimuli in the contralateral ear. The effect of acoustic bandwidth on bimodal benefit in children was compared with the pattern of adults with normal hearing. Our hypothesis was that children would require a wider acoustic bandwidth than adults to (1) derive bimodal benefit, and... περισσότερα »
Mandarin Tone and Vowel Recognition
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
in Cochlear Implant Users: Effects of Talker Variability and Bimodal Hearing: Objectives: For cochlear implant (CI) users with residual low-frequency acoustic hearing in the nonimplanted ear, bimodal hearing combining the use of a CI and a contralateral hearing aid (HA) may provide more salient talker voice cues than CI alone to handle the variability of talker identity across trials. This study tested the effects of talker variability, bimodal hearing, and their interaction on response accuracy and time of CI users’ Mandarin tone, vowel, and syllable recognition (i.e., combined Ma... περισσότερα »
Hearing Loss
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Is Hearing Loss Associated with Poorer Health in Older Adults Who Might Benefit from Hearing Screening?: Objectives: Hearing screening programs may benefit adults with unacknowledged or unaddressed hearing loss, but there is limited evidence regarding whether such programs are effective at improving health outcomes. The objective was to determine if poorer audiometric hearing thresholds are associated with poorer cognition, social isolation, burden of physical or mental health, inactivity due to poor physical or mental health, depression, and overnight hospitalizations among older A...περισσότερα »
Matching Automatic Gain Control Across Devices
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
in Bimodal Cochlear Implant Users: Objectives: The purpose of this study was to improve bimodal benefit in listeners using a cochlear implant (CI) and a hearing aid (HA) in contralateral ears, by matching the time constants and the number of compression channels of the automatic gain control (AGC) of the HA to the CI. Equivalent AGC was hypothesized to support a balanced loudness for dynamically changing signals like speech and improve bimodal benefit for speech understanding in quiet and with noise presented from the side(s) at 90 degree. Design: Fifteen subjects participated in t...περισσότερα »
Nonlinguistic Outcome Measures in Adult Cochlear Implant Users
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Over the First Year of Implantation: Objectives: Postlingually deaf cochlear implant users’ speech perception improves over several months after implantation due to a learning process which involves integration of the new acoustic information presented by the device. Basic tests of hearing acuity might evaluate sensitivity to the new acoustic information and be less sensitive to learning effects. It was hypothesized that, unlike speech perception, basic spectral and temporal discrimination abilities will not change over the first year of implant use. If there were limited change ov... περισσότερα »
Benefits to Speech Perception in Noise
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
From the Binaural Integration of Electric and Acoustic Signals in Simulated Unilateral Deafness: Objectives: This study used vocoder simulations with normal-hearing (NH) listeners to (1) measure their ability to integrate speech information from an NH ear and a simulated cochlear implant (CI), and (2) investigate whether binaural integration is disrupted by a mismatch in the delivery of spectral information between the ears arising from a misalignment in the mapping of frequency to place. Design: Eight NH volunteers participated in the study and listened to sentences embedded in bac... περισσότερα »
Qualities of Single Electrode Stimulation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
as a Function of Rate and Place of Stimulation with a Cochlear Implant: Objectives: Although it has been shown previously that changes in temporal coding produce changes in pitch in all cochlear regions, research has suggested that temporal coding might be best encoded in relatively apical locations. The authors hypothesized that although temporal coding may provide useable information at any cochlear location, low rates of stimulation might provide better sound quality in apical regions that are more likely to encode temporal information in the normal ear. In the present study, so... περισσότερα »
EMT (EMT, EMT-Advanced, EMT-Intermediate) (Non-Firefighting) - Klamath County Fire District No. 1
Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
from EMS via xlomafota13 on Inoreader http://ift.tt/1T3lioq
EMS Positions (non-firefighting) - Klamath County Fire District No. 1
Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
from EMS via xlomafota13 on Inoreader http://ift.tt/1SNVym3
Chewing efficiency and maximum bite force with different attachment systems of implant overdentures: a crossover study
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 58 δευτερόλεπτα
Abstract Purpose This crossover study aimed to evaluate and compare chewing efficiency and maximum bite force (MBF) with resilient telescopic and bar attachment systems of implant overdentures in patients with atrophied mandibles. Material and methods Ten participants with severely resorbed mandibles and persistent denture problems received new maxillary and mandibular conventional dentures (control, CD). After 3 months of adaptation, two implants were inserted in canine region of the mandible. In a quasi-random method, overdentures were connected to the implants with either bar ... περισσότερα »
The nutritional state of children and adolescents with cerebral palsy is associated with oral motor dysfunction and social conditions: a cross sectional study
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Abstract Background Cerebral palsy (CP) is the main cause of severe physical impairment during childhood and has commonly shown oral motor association. It has been considered as the main cause of the high prevalence of problems in children's nutrition. Respiration, chewing, swallowing, speaking and facial expressionare part of the orofacial motor functions and when affected they can interfere in children's well-being. The aim of this study was to correlate two methods of orofacial motor evaluation, analyze the influence of orofacial motor functional impairment on the nutritional st... περισσότερα »
CNS vasculitis and stroke as a complication of DOCK8 deficiency: a case report
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Abstract Background Primary immunodeficiency disorders associated with autoimmunity are poorly understood. Central nervous system (CNS) vasculitis can complicate the courses of such entities, but it is underappreciated. Deletion of the *dedicator of cytokinesis 8* (*DOCK8*) gene is considered to be the autosomal recessive form of hyperimmunoglobulin E syndrome which is a rare type of primary immunodeficiency disease characterized by elevated levels of IgE antibody, eczema, and recurrent staphylococcal infections. DOCK8 deletion is associated with fatal CNS vasculitis. However, desc...περισσότερα »
Treatment of a Giant Fusiform Basilar Aneurysm with Partial Intra-Aneurysmal Embolization Combined with Mid-Basilar Artery Occlusion in a Child
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
from Neurology via xlomafota13 on Inoreader http://ift.tt/1TcPONc via IFTTT
The Effects of Acoustic Bandwidth on Simulated Bimodal Benefit in Children and Adults with Normal Hearing
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 1 ώρα
[image: image]Objectives: The primary purpose of this study was to examine the effect of acoustic bandwidth on bimodal benefit for speech recognition in normal-hearing children with a cochlear implant (CI) simulation in one ear and low-pass filtered stimuli in the contralateral ear. The effect of acoustic bandwidth on bimodal benefit in children was compared with the pattern of adults with normal hearing. Our hypothesis was that children would require a wider acoustic bandwidth than adults to (1) derive bimodal benefit, and (2) obtain asymptotic bimodal benefit. Design: Nineteen chi... περισσότερα »
Frequency–Amplitude Ratio of Ocular Vestibular-Evoked Myogenic Potentials for Detecting Meniere’s Disease: A Preliminary Investigation
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 1 ώρα
[image: image]Objective: Several parameters of ocular vestibular-evoked myogenic potential (oVEMP) have been used to identify Meniere's disease. Nonetheless frequency–amplitude ratio (FAR), which is the ratio of amplitude between two frequencies, is one among the parameters that has failed to attract researchers' attention despite proving its worth in diagnosis of Meniere's disease when used in conjunction with cervical VEMP. Thus, the present study aimed at investigating the utility of FAR of oVEMP in identifying Meniere's disease and finding out an optimum frequency pair for its d... περισσότερα »
Diabetes-Associated Changes in Cortical Auditory-Evoked Potentials in Relation to Normal Aging
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 1 ώρα
[image: image]Objectives: (1) To characterize the influence of type 2 diabetes mellitus (DM) on cortical auditory-evoked potentials (CAEPs) separate from the effects of normal aging, and (2) to determine whether the disease-related effects are modified by insulin dependence. Design: A cross-sectional study was conducted in a large cohort of Veterans to investigate the relationships among type 2 DM, age, and CAEPs in randomly selected participants with (N = 108) and without (N = 114) the disease and who had no more than a moderate hearing loss. Participants with DM were classified as... περισσότερα »
The Use of the Kurtosis-Adjusted Cumulative Noise Exposure Metric in Evaluating the Hearing Loss Risk for Complex Noise
Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 1 ώρα
[image: image]Objective: To test a kurtosis-adjusted cumulative noise exposure (CNE) metric for use in evaluating the risk of hearing loss among workers exposed to industrial noises. Specifically, to evaluate whether the kurtosis-adjusted CNE (1) provides a better association with observed industrial noise-induced hearing loss, and (2) provides a single metric applicable to both complex (non-Gaussian [non-G]) and continuous or steady state (Gaussian [G]) noise exposures for predicting noise-induced hearing loss (dose–response curves). Design: Audiometric and noise exposure data were... περισσότερα »
Benefits to Speech Perception in Noise From the Binaural Integration of Electric and Acoustic Signals in Simulated Unilateral Deafness
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: image]Objectives: This study used vocoder simulations with normal-hearing (NH) listeners to (1) measure their ability to integrate speech information from an NH ear and a simulated cochlear implant (CI), and (2) investigate whether binaural integration is disrupted by a mismatch in the delivery of spectral information between the ears arising from a misalignment in the mapping of frequency to place. Design: Eight NH volunteers participated in the study and listened to sentences embedded in background noise via headphones. Stimuli presented to the left ear were unprocessed. S...περισσότερα »
Nonlinguistic Outcome Measures in Adult Cochlear Implant Users Over the First Year of Implantation
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: image]Objectives: Postlingually deaf cochlear implant users' speech perception improves over several months after implantation due to a learning process which involves integration of the new acoustic information presented by the device. Basic tests of hearing acuity might evaluate sensitivity to the new acoustic information and be less sensitive to learning effects. It was hypothesized that, unlike speech perception, basic spectral and temporal discrimination abilities will not change over the first year of implant use. If there were limited change over time and the test sco... περισσότερα »
Matching Automatic Gain Control Across Devices in Bimodal Cochlear Implant Users
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: image]Objectives: The purpose of this study was to improve bimodal benefit in listeners using a cochlear implant (CI) and a hearing aid (HA) in contralateral ears, by matching the time constants and the number of compression channels of the automatic gain control (AGC) of the HA to the CI. Equivalent AGC was hypothesized to support a balanced loudness for dynamically changing signals like speech and improve bimodal benefit for speech understanding in quiet and with noise presented from the side(s) at 90 degree. Design: Fifteen subjects participated in the study, all using th... περισσότερα »
Is Hearing Loss Associated with Poorer Health in Older Adults Who Might Benefit from Hearing Screening?
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: image]Objectives: Hearing screening programs may benefit adults with unacknowledged or unaddressed hearing loss, but there is limited evidence regarding whether such programs are effective at improving health outcomes. The objective was to determine if poorer audiometric hearing thresholds are associated with poorer cognition, social isolation, burden of physical or mental health, inactivity due to poor physical or mental health, depression, and overnight hospitalizations among older American adults with unacknowledged or unaddressed hearing loss. Design: The authors perform... περισσότερα »
Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Treatments to reverse peanut allergy remain elusive. Current clinical approaches using peanut oral/sublingual immunotherapy are promising, but concerns about safety and long-term benefit remain a barrier to wide use. Improved methods of delivering peanut-specific immunotherapy are needed. from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1MXFkVl via IFTTT
Immunoglobulin G and G4 to 91 allergenic molecules in early childhood by route of exposure, current and future IgE-sensitization: a MAS birth cohort study
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
IgG responses to an array of 91 allergenic molecules were significantly more frequent in IgE-sensitized than in non-sensitized 2-year-old probands of the MAS birth cohort study, and they followed in both population subsets the same order (animal foodborne>vegetable foodborne>airborne). from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1MXFmMK via IFTTT
Epirubicin dose and sequential hormonal therapy—Mature results of the HMFEC randomised phase III trial in premenopausal patients with node positive early breast cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: June 2016 Source:European Journal of Cancer, Volume 60 Author(s): R.C. Coombes, L.S. Kilburn, N. Tubiana-Mathieu, T. Olmos, A. Van Bochove, F.R. Perez-Lopez, C. Palmieri, J. Stebbing, J.M. Bliss BackgroundThe hormonal manipulation 5-Fluoro-uracil Epirubicin Cyclophosphamide (HMFEC) trial was developed at a time of uncertainty around the dose intensity of chemotherapy given to premenopausal patients […]
Delayed Diagnosis, Leprosy Reactions, and Nerve Injury Among Individuals With Hansen’s Disease Seen at a United States Clinic
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background. Hansen’s disease (HD), or leprosy, is uncommon in the United States. We sought to describe the characteristics of patients with HD in a US clinic, including an assessment of delays in diagnosis and HD reactions, which have both been associated with nerve damage. Methods. A retrospective chart review was conducted on patients seen at […]
Erratum to: Monte Carlo dosimetry of the IRAsource high dose rate 192 Ir brachytherapy source
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TcOtWu via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Review of 3D image data calibration for heterogeneity correction in proton therapy treatment planning
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Correct modelling of the interaction parameters of patient tissues is of vital importance in proton therapy treatment planning because of the large dose gradients associated with the Bragg peak. Different 3D imaging techniques yield different information regarding these interaction parameters. Given the rapidly expanding interest in proton therapy, this review is written to make […]
Inhibition of bone loss with surface-modulated, drug-loaded nanoparticles in an intraosseous model of prostate cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: 28 June 2016 Source:Journal of Controlled Release, Volume 232 Author(s): Isaac M. Adjei, Blanka Sharma, Chiranjeevi Peetla, Vinod Labhasetwar Advanced-stage prostate cancer usually metastasizes to bone and is untreatable due to poor biodistribution of intravenously administered anticancer drugs to bone. In this study, we modulated the surface charge/composition of biodegradable nanoparticles (NPs) to […]
Perivascular sustained release of atorvastatin from a hydrogel-microparticle delivery system decreases intimal hyperplasia
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: 28 June 2016 Source:Journal of Controlled Release, Volume 232 Author(s): Ioanna Mylonaki, Francesco Strano, Sebastien Deglise, Eric Allémann, Florian Alonso, Jean-Marc Corpataux, Céline Dubuis, Jacques-Antoine Haefliger, Olivier Jordan, François Saucy, Florence Delie Intimal hyperplasia (IH) is the major cause of grafted vessel occlusion and occurs frequently after bypass intervention. No pharmaceutical formulation is […]
Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: 28 June 2016 Source:Journal of Controlled Release, Volume 232 Author(s): Jennifer K. Saucier-Sawyer, Young-Eun Seo, Alice Gaudin, Elias Quijano, Eric Song, Andrew J. Sawyer, Yang Deng, Anita Huttner, W. Mark Saltzman Glioblastoma multiforme (GBM) is a fatal brain tumor characterized by infiltration beyond the margins of the main tumor mass and local recurrence […]
Oral hypoglycaemic effect of GLP-1 and DPP4 inhibitor based nanocomposites in a diabetic animal model
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: 28 June 2016 Source:Journal of Controlled Release, Volume 232 Author(s): Neha Shrestha, Francisca Araújo, Mohammad-Ali Shahbazi, Ermei Mäkilä, Maria João Gomes, Mikko Airavaara, Esko I. Kauppinen, Janne Raula, Jarno Salonen, Jouni Hirvonen, Bruno Sarmento, Hélder A. Santos Glucagon-like peptide-1 (GLP-1), an incretin hormone, is used for type 2 diabetes mellitus (T2DM) treatment because […]
Investigations into the absorption of insulin and insulin derivatives from the small intestine of the anaesthetised rat
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: 28 June 2016 Source:Journal of Controlled Release, Volume 232 Author(s): B.J. McGinn, J.D. Morrison Experiments have been undertaken to determine the extent to which cholic acid conjugates of insulin were absorbed from the small intestine of anaesthetised rats by means of the bile salt transporters of the ileum. The measure used to assess […]
An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: 28 June 2016 Source:Journal of Controlled Release, Volume 232 Author(s): Konrad Bienk, Michael Lykke Hvam, Malgorzata Maria Pakula, Frederik Dagnæs-Hansen, Jesper Wengel, Birgitte Mølholm Malle, Ulrich Kragh-Hansen, Jason Cameron, Jens Thostrup Bukrinski, Kenneth A. Howard Major challenges for the clinical translation of small interfering RNA (siRNA) include overcoming the poor plasma half-life, site-specific […]
Respiratory and hemodynamic outcomes following exchange extubation with laryngeal mask airway as compared to traditional awake extubation
Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 1 ώρα
*Ramanathan Kannan Suppiah, Sunil Rajan, Jerry Paul, Lakshmi Kumar* Anesthesia: Essays and Researches 2016 10(2):212-217 Background: Traditional awake extubation leads to respiratory complications and hemodynamic response which are detrimental in neurosurgery, ENT surgery and patients with comorbidities. Aims: The primary objective was to compare the respiratory complications and hemodynamic stress response between traditional awake extubation of a endotracheal tube (ETT) and that following exchange extubation of ETT by using a laryngeal mask airway (LMA). Settings and Design: This ... περισσότερα »
Neuroprotection of ischemic preconditioning is mediated by thioredoxin 2 in the hippocampal CA1 region following a subsequent transient cerebral ischemia
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Preconditioning by brief ischemic episode induces tolerance to a subsequent lethal ischemic insult, and it has been suggested that reactive oxygen species are involved in this phenomenon. Thioredoxin 2 (Trx2), a small protein with redox-regulating function, shows cytoprotective roles against oxidative stress. Here, we had focused on the role of Trx2 in ischemic preconditioning (IPC)-mediated neuroprotection against oxidative stress followed by a subsequent lethal transient cerebral ischemia. Animals used in this study were randomly assigned to 6 groups; sham-operated group... περισσότερα »
Transoral Segmental Resection and Disarticulation of Mandible with Immediate Nonvascularized Reconstruction: A Case Report
Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 2 ώρες
Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0036-1582456 Disarticulation resections are required for treatment of variety of pathologies of the jaws. These resections are mostly carried out through extraoral approach, which bear significant postoperative morbidity. The transoral approach may be used for this purpose in benign pathological cases of the mandible to limit the postoperative morbidity of extraoral approach, as it provides sufficient access not only for resection and disarticulation but also for immediate reconstruction. This article shares our experience wi... περισσότερα »
Cortical Activation Patterns Correlate with Speech Understanding After Cochlear Implantation
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Objectives: Cochlear implants are a standard therapy for deafness, yet the ability of implanted patients to understand speech varies widely. To better understand this variability in outcomes, the authors used functional near-infrared spectroscopy to image activity within regions of the auditory cortex and compare the results to behavioral measures of speech perception. Design: The authors… Continue reading Cortical Activation Patterns Correlate with Speech Understanding After Cochlear Implantation
Frequency–Amplitude Ratio of Ocular Vestibular-Evoked Myogenic Potentials for Detecting Meniere’s Disease: A Preliminary Investigation
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Objective: Several parameters of ocular vestibular-evoked myogenic potential (oVEMP) have been used to identify Meniere’s disease. Nonetheless frequency–amplitude ratio (FAR), which is the ratio of amplitude between two frequencies, is one among the parameters that has failed to attract researchers’ attention despite proving its worth in diagnosis of Meniere’s disease when used in conjunction with… Continue reading Frequency–Amplitude Ratio of Ocular Vestibular-Evoked Myogenic Potentials for Detecting Meniere’s Disease: A Preliminary Investigation
Transoral Segmental Resection and Disarticulation of Mandible with Immediate Nonvascularized Reconstruction: A Case Report
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0036-1582456 Disarticulation resections are required for treatment of variety of pathologies of the jaws. These resections are mostly carried out through extraoral approach, which bear significant postoperative morbidity. The transoral approach may be used for this purpose in benign pathological cases of the mandible to limit the postoperative morbidity of […]
Oral lichen planus clinical characteristics in Italian patients: a retrospective analysis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Oral lichen Planus (OLP) is a chronic inflammatory disease involving skin and mucous membranes. Its etiology is still uncertain whilst an autoimmune mechanism is known to be implicated. OLP is commonly conside… from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1XVX1Fd via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs […]
Considering the survivorship care needs of head and neck cancer survivors
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
The American Cancer Society Head and Neck Cancer Survivorship Care Guideline was recently published in CA: A Cancer Journal for Clinicians. This synthesis of systematic literature review and consensus opinion from a multidisciplinary expert workgroup represents the fourth in a series of cancer site-specific adult post-treatment cancer survivorship care guidelines, with other guidelines addressing breast, […]
Response to letter Re: Extensive oral mucosal hyperkeratosis caused by over-the-counter long lasting snoring relief agent
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
We are writing with regard to the letter from a representative of the manufacturer of the snoring relief agent Snoreeze,1 which was sent in response to our recent publication «Extensive oral mucosal hyperkeratosis caused by over-the-counter long lasting snoring relief agent».2 from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1Ny2QIz via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 […]
Salivary Cortisol Profiles of Children with Hearing Loss
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Objectives: It has long been speculated that effortful listening places children with hearing loss at risk for fatigue. School-age children with hearing loss experiencing cumulative stress and listening fatigue on a daily basis might undergo dysregulation of hypothalamic–pituitary–adrenal (HPA) axis activity resulting in elevated or flattened cortisol profiles. The purpose of this study was to […]
Monothermal Caloric Screening to Improve Healthcare Value
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Objectives: To evaluate whether monothermal caloric screening can reduce the number of caloric irrigations required in the vestibular testing battery while maintaining diagnostic accuracy. Design: Prospective controlled cohort study. Three hundred and ninety patients referred for vestibular testing at this tertiary referral health system over a 1-year period were evaluated; 24 patients met exclusion or […]
Response to letter Re: Extensive oral mucosal hyperkeratosis caused by over-the-counter long lasting snoring relief agent
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
We are writing with regard to the letter from a representative of the manufacturer of the snoring relief agent Snoreeze,1 which was sent in response to our recent publication “Extensive oral mucosal hyperkeratosis caused by over-the-counter long lasting snoring relief agent”.2 from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1Ny2QIz via IFTTT from #Med Blogs by Alexandros […]
Oral and craniofacial manifestations of Ellis-van Creveld syndrome: Case series
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
To evaluate and compare the short-term skeletal and dental changes following surgically assisted rapid maxillary expansion (SARME) with or without pterygomaxillary disjunction (PTMD) using cone beam computed tomography (CBCT). from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1VR7Wmq via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1qRFzXy via IFTTT
Effect of fronto-orbital advancement on astigmatism in patients with anterior plagiocephaly
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
The purpose of this study was to determine the effect of unilateral fronto-orbital advancement (FOA) or bilateral FOA on ocular aspects of plagiocephaly. A retrospective review of ocular findings in 16 patients with plagiocephaly was performed. Patients were divided into 2 groups: 12 patients who underwent bilateral FOA (bFOA) and 4 patients who underwent unilateral […]
Low disease causing threshold in a frog species susceptible to chytridiomycosis
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 3 ώρες
A simple diagnosis of the presence or absence of an infection is an uninformative metric when individuals differ considerably in their tolerance to different infection loads or resistance to rates of disease progression. Models that incorporate the relationship between the progression of the infection with the potential alternate outcomes provide a far more powerful predictive tool than diagnosis alone. The global decline of amphibians has been amplified by *Batrachochytrium dendrobatidis*, a pathogen that can cause the fatal disease chytridiomycosis. We measured the infection loa...περισσότερα »
Lichen-forming fungus Caloplaca flavoruscens inhibits transcription factors and chromatin remodeling system in fungi
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 3 ώρες
Lichen-forming fungi and extracts derived from them have been used as alternative medicine sources for millennia and recently there has been a renewed interest in their known bioactive properties for anticancer agents, cosmetics and antibiotics. Although lichen-forming fungus derived compounds are biologically and commercially valuable, few studies have been performed to determine their modes of action. This study used chemical-genetic and chemogenomic high-throughput analyses to gain insight into the modes of action of *Caloplaca flavoruscens* extracts. High-throughput screening o...περισσότερα »
Diversity and distribution of catechol 2, 3-dioxygenase genes in surface sediments of the Bohai Sea
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 3 ώρες
Catechol 2, 3-dioxygenase (C23O) is the key enzyme for aerobic aromatic degradation. Based on clone libraries and qPCR, we characterized diversity and distribution patterns of C23O genes in surface sediments of the Bohai Sea. The results showed that sediments of the Bohai Sea were dominated by the sequences related to C23O subfamily I.2.A. The samples from wastewater discharge area (DG) and aquaculture farm (KL) showed distinct composition of C23O genes when compared to the samples from Bohai Bay (BH), and TOC was a crucial determinant accounted for the composition variation. C6BH1... περισσότερα »
Zika virus in Brazilian non-human primates
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 3 ώρες
Zika virus RNA has been detected in New World monkeys from the Northeast region of Brazil. This finding suggests that primates may serve as a reservoir host for the virus, as occurs in Africa. from Infection via ola Kala on Inoreader http://ift.tt/1QzbbX0 via IFTTT
An Islanded Rabbit Auricular Skin Flap Model of Hyaluronic Acid Injection-Induced Embolism
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
Abstract Background Hyaluronic acid (HA) injection-induced embolism is a rare but severe complication. This article is aimed to introduce an islanded rabbit auricular skin flap model of HA injection-induced embolism and to study its pathophysiological progress. Methods An islanded skin flap was elevated based on the proximal central auricular artery/vein. Eighteen rabbits were randomized into […]
The Side Effects of Facial Implants
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 3 ώρες
This case report is about a 64-year-old woman who presented at the Emergency Walk-in Center with palpebral edema as well as various erythematous plaques in supraciliary and malar areas that have been gradually worsening a couple of days prior to presentation. While talking about history, the patient mentioned she was attending, for about four months, an Esthetic Private Clinic, where she was injected in various sessions with Metacrill®, as a facial lift, for beauty purpose. Due to suspecting an allergic reaction to the Metacrill and the failure of the initial treatments, she was r... περισσότερα »
World Immunisation Week 2016
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 3 ώρες
*By Hemali Bedi* "The two public health interventions that have had the greatest impact on the world's healt[image: poster-large]h are clean water and vaccines." – *The World Health Organization* [1] World Immunisation week takes place each year during last week of April (24-30). Last year, over 180 countries took part in the campaign, which is coordinated by The World Health Organization (WHO). [2] During this time, WHO encourage the uptake of vaccines and highlight need to improve equitable access to immunisations worldwide. [2] Immunisation prevents between 2 to 3 million deat... περισσότερα »
