Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Πέμπτη 4 Φεβρουαρίου 2016

OtoRhinoLaryngology & Medicine,New Articles,February 4th,2016,a


Auditory risk of air rifles.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 λεπτό
*Auditory risk of air rifles.* Int J Audiol. 2016 Feb;55(sup1):S51-S58 Authors: Lankford JE, Meinke DK, Flamme GA, Finan DS, Stewart M, Tasko S, Murphy WJ Abstract OBJECTIVE: To characterize the impulse noise exposure and auditory risk for air rifle users for both youth and adults. DESIGN: Acoustic characteristics were examined and the auditory risk estimates were evaluated using contemporary damage-risk criteria for unprotected adult listeners and the 120-dB peak limit and LAeq75 exposure limit suggested by the World Health Organization (1999) for children. STUDY SAMPLE: Impulses...περισσότερα »

Speech recognition in noise under hearing protection: A computational study of the combined effects of hearing loss and hearing protector attenuation.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 λεπτό
*Speech recognition in noise under hearing protection: A computational study of the combined effects of hearing loss and hearing protector attenuation.* Int J Audiol. 2016 Feb;55(sup1):S30-S40 Authors: Giguère C, Berger EH Abstract OBJECTIVE: To investigate the effects of hearing protection on speech recognition in noise. DESIGN: Computational study using a speech recognition model that was previously empirically validated. STUDY SAMPLE: Recognition scores were calculated in unprotected and protected conditions for four sets of hearing protector attenuation functions in two diffe...περισσότερα »

Celebrating hearing loss prevention.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 λεπτό
*Celebrating hearing loss prevention.* Int J Audiol. 2016 Feb;55(sup1):S1-S2 Authors: Le Prell CG, Grantham MA PMID: 26840921 [PubMed - as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1NRMQKD via IFTTT

High-grade malignant transformation of a radiation-naïve nasopharyngeal angiofibroma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 λεπτό
*High-grade malignant transformation of a radiation-naïve nasopharyngeal angiofibroma.* Head Neck. 2016 Feb 3; Authors: Allensworth JJ, Troob SH, Lanciault C, Andersen PE Abstract BACKGROUND: Nasopharyngeal angiofibromas are typically considered benign vascular neoplasms, with descriptions of high-grade sarcomatous change found only in lesions with prior radiotherapy. METHODS AND RESULTS: We describe the first reported case of high-grade malignant change in a nasopharyngeal angiofibroma naive to radiation. A 45-year-old man presented with left-sided nasal congestion and fullness a... περισσότερα »

Hypothesis: solid tumours behave as systemic metabolic dictators

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
Abstract Current knowledge regarding mechanisms of carcinogenesis in human beings centres around the accumulation of genetic instability, amplified cellular signalling, disturbed cellular energy metabolism and microenvironmental regulation governed by complicated cell–cell interactions. In this article, we provide an alternative view of cancer biology. We propose that cancer behaves as a systemic dictator that interacts with tissues throughout the body to control their metabolism and eventually homeostasis. The mechanism of development of this endocrine organ–like tumour (EOLT) tis... περισσότερα »

upper respiratory tract infection; +26 new citations

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/02/04 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 2 via ola Kala on Inoreader http://ift.tt/20sSYWk via IFTTT

Abdominal Imaging with Contrast-enhanced Photon-counting CT: First Human Experience.

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
*Abdominal Imaging with Contrast-enhanced Photon-counting CT: First Human Experience.* Radiology. 2016 Feb 3;:152601 Authors: Pourmorteza A, Symons R, Sandfort V, Mallek M, Fuld MK, Henderson G, Jones EC, Malayeri AA, Folio LR, Bluemke DA Abstract Purpose To evaluate the performance of a prototype photon-counting detector (PCD) computed tomography (CT) system for abdominal CT in humans and to compare the results with a conventional energy-integrating detector (EID). Materials and Methods The study was HIPAA-compliant and institutional review board-approved with informed consent. ... περισσότερα »

Relationship of Bowel MR Imaging to Health-related Quality of Life Measures in Newly Diagnosed Pediatric Small Bowel Crohn Disease.

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
*Relationship of Bowel MR Imaging to Health-related Quality of Life Measures in Newly Diagnosed Pediatric Small Bowel Crohn Disease.* Radiology. 2016 Feb 3;:151727 Authors: Dillman JR, Carlos RC, Smith EA, Davenport MS, De Matos Maillard V, Adler J Abstract Purpose To determine if utility measures of health-related quality of life (HRQOL) in pediatric small bowel Crohn disease (a) change in response to infliximab therapy, (b) correlate with proxy parent or guardian assessments, and (c) correlate with magnetic resonance (MR) imaging and laboratory markers of intestinal active infl...περισσότερα »

Cytologic and Histologic Features of Pleomorphic Undifferentiated Sarcoma Arising in a Hybrid Hemosiderotic Fibrolipomatous Tumor and Pleomorphic Hyalinizing Angiectatic Tumor: Report of an Unusual Case with a Literature Review.

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
*Cytologic and Histologic Features of Pleomorphic Undifferentiated Sarcoma Arising in a Hybrid Hemosiderotic Fibrolipomatous Tumor and Pleomorphic Hyalinizing Angiectatic Tumor: Report of an Unusual Case with a Literature Review.* Acta Cytol. 2016 Feb 4; Authors: Morency E, Laskin W, Lin X Abstract BACKGROUND: Pleomorphic hyalinizing angiectatic tumor (PHAT) and hemosiderotic fibrolipomatous tumor (HFLT) are low-grade neoplasms that share clinicopathologic features and recurring translocation t(1;10)(p22;q24) involving the TGFBR3 and MGEA5 genes. Coexistence of these tumors with... περισσότερα »

Can We Be Less Radical with Surgery for Early Cervical Cancer?

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
*Can We Be Less Radical with Surgery for Early Cervical Cancer?* Curr Oncol Rep. 2016 Mar;18(3):16 Authors: Macdonald MC, Tidy JA Abstract Although a rare cancer in the developed world due to the success of cervical screening programmes, cervical cancer remains one of the most common cancers diagnosed in women under the age of 35 years old. Radical hysterectomy and more recently radical trachelectomy have been highly effective in curing the majority of women with early stage disease. Many, however, are left with long-term 'survivorship' issues including bowel, bladder and sexual ...περισσότερα »

Primary alveolar soft part sarcoma of uterine corpus: a case report with immunohistochemical, ultrastructural study and review of literature.

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
*Primary alveolar soft part sarcoma of uterine corpus: a case report with immunohistochemical, ultrastructural study and review of literature.* World J Surg Oncol. 2016;14(1):24 Authors: Giordano G, D'Adda T, Varotti E, Crovini G, Silini EM Abstract BACKGROUND: Alveolar soft part sarcoma (ASPS) is a rare mesenchymal malignancy. ASPS usually occurs most commonly in the deep soft tissues of the thigh and buttock or the head and neck regions. ASPS that originate from the uterine corpus are even more rare, with only 10 previous cases reported in the English literature. CASE PRESENTATI...περισσότερα »

Jakob Erdheim (1874-1937): father of hypophyseal-duct tumors (craniopharyngiomas).

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
[image: http:--production.springer.de-OnlineReso] Related Articles *Jakob Erdheim (1874-1937): father of hypophyseal-duct tumors (craniopharyngiomas).* Virchows Arch. 2015 Oct;467(4):459-69 Authors: Pascual JM, Rosdolsky M, Prieto R, Strauβ S, Winter E, Ulrich W Abstract Jakob Erdheim (1874-1937) was a Viennese pathologist who identified and defined a category of pituitary tumors known as craniopharyngiomas. He named these lesions "hypophyseal duct tumors" (Hypophysenganggeschwülste), a term denoting their presumed origin from cell remnants of the hypophyseal duct, the embryologi... περισσότερα »

Extreme delta brush guides to the diagnosis of anti-NMDAR encephalitis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Extreme delta brush guides to the diagnosis of anti-NMDAR encephalitis.* J Neurol Sci. 2015;353(1-2):81-3 Authors: Wang J, Wang K, Wu D, Liang H, Zheng X, Luo B Abstract Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a treatable but often misdiagnosed autoimmune encephalitis. Diagnosis depends on NMDAR antibody testing, which may not be readily available. Alternatively, the electroencephalogram (EEG) extreme delta brush pattern may provide a valuable immediate indicator for the diagnosis of anti-N... περισσότερα »

Cholecystocolic fistula caused by gallbladder carcinoma: preoperatively misdiagnosed as hepatic colon carcinoma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Cholecystocolic fistula caused by gallbladder carcinoma: preoperatively misdiagnosed as hepatic colon carcinoma.* World J Gastroenterol. 2015 Apr 21;21(15):4765-9 Authors: Ha GW, Lee MR, Kim JH Abstract Cholecystocolic fistula secondary to gallbladder carcinoma is extremely rare and has been reported in very few studies. Most cholecystocolic fistulae are late complications of gallstone disease, but can also develop following carcinoma of the gallbladder when the necrotic tumor penetrates... περισσότερα »

Letter to the Editor: Re: Are Biochemical Markers of Bone Turnover Representative of Bone Histomorphometry in 370 Postmenopausal Women?

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
*Letter to the Editor: Re: Are Biochemical Markers of Bone Turnover Representative of Bone Histomorphometry in 370 Postmenopausal Women?* J Clin Endocrinol Metab. 2016 Feb;101(2):L24-L25 Authors: Reeve J PMID: 26840111 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1S2sJ3X via IFTTT

Response to the Letter: Response to "Use of biomarkers to identify new drug targets and to predict risk of cardiometabolic outcomes" by Abasi A., et al.

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
*Response to the Letter: Response to "Use of biomarkers to identify new drug targets and to predict risk of cardiometabolic outcomes" by Abasi A., et al.* J Clin Endocrinol Metab. 2016 Feb;101(2):L22-L23 Authors: Holmegard HN, Nordestgaard BG, Jensen GB, Tybjærg-Hansen A, Benn M PMID: 26840110 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1PUbiwj via IFTTT

A case of metastatic renal cell carcinoma and bile duct carcinoma treated with a combination of sunitinib and gemcitabine.

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *A case of metastatic renal cell carcinoma and bile duct carcinoma treated with a combination of sunitinib and gemcitabine.* BMC Cancer. 2015;15:426 Authors: Takayoshi K, Sagara K, Uchino K, Kusaba H, Sakamoto N, Iguchi A, Baba E Abstract BACKGROUND: Metastatic renal cell carcinoma (mRCC) had been a chemo-refractory disease, but recent advances in multiple kinase inhibitors such as sunitinib have dramatically changed the clinical course of mRCC. Sunitinib is used for mRCC chemotherapy ba... περισσότερα »

Updates in the management of diabetic macular edema.

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
[image: http:--images.hindawi.com-linkout-hindaw] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Updates in the management of diabetic macular edema.* J Diabetes Res. 2015;2015:794036 Authors: Mathew C, Yunirakasiwi A, Sanjay S Abstract Diabetes mellitus is a chronic disease which has multiple effects on different end-organs, including the retina. In this paper, we discuss updates on diabetic macular edema (DME) and the management options. The underlying pathology of DME is the leakage of exudates from retinal microaneurysms, which trigger subsequent inflammatory reactio...περισσότερα »

The SOFT trial: a Phase III study of the dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine S-1 and oxaliplatin (SOX) plus bevacizumab as first-line chemotherapy for metastatic colorectal cancer.

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
[image: http:--http://ift.tt/1TFZe7K] Related Articles *The SOFT trial: a Phase III study of the dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine S-1 and oxaliplatin (SOX) plus bevacizumab as first-line chemotherapy for metastatic colorectal cancer.* Future Oncol. 2015;11(10):1471-8 Authors: Nakamura M, Yamada Y, Muro K, Takahashi K, Baba H, Sasaki Y, Komatsu Y, Satoh T, Mishima H, Watanabe M, Sakata Y, Morita S, Shimada Y, Sugihara K Abstract A combination of oxaliplatin, leucovorin and 5-fluorouracil (FOLFOX) plus bevacizumab has been widely used for the first-line c... περισσότερα »

Hemiscorpius lepturus venom induces expression and production of interluckin-12 in human monocytes.

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Hemiscorpius lepturus venom induces expression and production of interluckin-12 in human monocytes.* Toxicon. 2015 Jun 15;100:27-31 Authors: Hadaddezfuli R, Khodadadi A, Assarehzadegan MA, Pipelzadeh MH, Saadi S Abstract The objective of this study was to evaluate the capacity of the venom from Hemiscorpius lepturus to induce expression and production of interleukin-12 (IL-12) on isolated human monocytes. For this purpose, isolated human monocytes (250,000-300,000 cells/ml) were exposed to different concentratio... περισσότερα »

Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis.* Autoimmunity. 2015 Jun;48(4):251-8 Authors: Suzuki S, Morimoto S, Fujishiro M, Kawasaki M, Hayakawa K, Miyashita T, Ikeda K, Miyazawa K, Yanagida M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y Abstract OBJECTIVE: We have shown that connective tissue growth factor (CTGF) plays an important role in the pathogenesis of rheumatoid arthritis (RA). Insulin-like growth factor binding proteins (IGFBPs) are modules of CTGF. IGFBPs b...περισσότερα »

Improving the estimation of flavonoid intake for study of health outcomes.

Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Improving the estimation of flavonoid intake for study of health outcomes.* Nutr Rev. 2015 Aug;73(8):553-76 Authors: Peterson JJ, Dwyer JT, Jacques PF, McCullough ML Abstract Imprecision in estimating intakes of non-nutrient bioactive compounds such as flavonoids is a challenge in epidemiologic studies of health outcomes. The sources of this imprecision, using flavonoids as an example, include the variability of bioactive compounds in foods due to differences in growing conditions and processing, the challenges in... περισσότερα »

High-grade malignant transformation of a radiation-naïve nasopharyngeal angiofibroma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*High-grade malignant transformation of a radiation-naïve nasopharyngeal angiofibroma.* Head Neck. 2016 Feb 3; Authors: Allensworth JJ, Troob SH, Lanciault C, Andersen PE Abstract BACKGROUND: Nasopharyngeal angiofibromas are typically considered benign vascular neoplasms, with descriptions of high-grade sarcomatous change found only in lesions with prior radiotherapy. METHODS AND RESULTS: We describe the first reported case of high-grade malignant change in a nasopharyngeal angiofibroma naive to radiation. A 45-year-old man presented with left-sided nasal congestion and fullness a... περισσότερα »

High-grade histology as predictor of early distant metastases and decreased disease-free survival in salivary gland cancer irrespective of tumor subtype.

Alexandros G. SfakianakisστοHead and NeckΠριν από 7 δευτερόλεπτα
*High-grade histology as predictor of early distant metastases and decreased disease-free survival in salivary gland cancer irrespective of tumor subtype.* Head Neck. 2016 Feb 3; Authors: Haderlein M, Scherl C, Semrau S, Lettmaier S, Uter W, Neukam FW, Iro H, Agaimy A, Fietkau R Abstract BACKGROUND: The purpose of this study was to evaluate risk factors that influence overall survival (OS)/disease-free survival (DFS)/locoregional recurrence-free survival (LRFS), and distant metastases-free survival (DMFS) in patients with high-risk primary salivary gland carcinoma who underwent ... περισσότερα »

Development of the Neonatal Intestinal Microbiome and Its Association With Necrotizing Enterocolitis

Alexandros G. SfakianakisστοΘεραπείαΠριν από 7 δευτερόλεπτα
Publication date: Available online 3 February 2016 *Source:*Clinical Therapeutics Author(s): Timothy G. Elgin, Stacy L. Kern, Steven J. McElroy PurposeNeonatal necrotizing enterocolitis (NEC) remains the most devastating gastrointestinal disease for premature infants. In the United States alone, NEC affects >4000 premature infants yearly, has a mortality rate of nearly 33%, and costs the health care system >$1 billion annually. Although NEC has been actively researched for several decades, its pathophysiology remains elusive. One potential mechanism suggests that disruption of the n...περισσότερα »

Daclatasvir and Sofosbuvir Versus Sofosbuvir and Ribavirin in Patients with Chronic Hepatitis C Coinfected with HIV: A Matching-adjusted Indirect Comparison

Alexandros G. SfakianakisστοΘεραπείαΠριν από 7 δευτερόλεπτα
Publication date: Available online 3 February 2016 *Source:*Clinical Therapeutics Author(s): Elyse Swallow, Jinlin Song, Yong Yuan, Anupama Kalsekar, Caroline Kelley, Miranda Peeples, Fan Mu, Peter Ackerman, James Signorovitch PurposeOur aim was to compare the efficacy and tolerability of daclatasvir plus sofosbuvir (DCV+SOF) versus SOF plus ribavirin (SOF+R) in patients coinfected with HIV and hepatitis C virus (HCV).MethodsA systematic literature review of Phase III clinical trials identified 2 trials of SOF+R—PHOTON-1 (A Phase 3, Open-Label Study to Investigate the Efficacy and S... περισσότερα »

Zhen-wu-tang attenuates cationic bovine serum albumin-induced inflammatory response in membranous glomerulonephritis rat through inhibiting AGEs/RAGE/NF-κB pathway activation

Alexandros G. SfakianakisστοΘεραπείαΠριν από 7 δευτερόλεπτα
Publication date: April 2016 *Source:*International Immunopharmacology, Volume 33 Author(s): Junbiao Wu, Bihao Liu, Chunling Liang, Hui Ouyang, Jin Lin, Yanchun Zhong, Yu He, Jie Zhou, Yuan Zhou, Jiuyao Zhou Zhen-wu-tang (ZWT), a traditional Chinese compound formula recorded in the Treatise on Febrile Diseases, has significant inhibitory effects on inflammatory damage and oxidative lesions in rats, but its mechanism of action remains unclear. The aim of the present study was to explore whether the anti-inflammatory and anti-oxidative effects of ZWT were mediated by the AGEs/RAGE/NF-... περισσότερα »

Evidence for the existence of nociceptors in rat thoracolumbar fascia

Alexandros G. SfakianakisστοΘεραπείαΠριν από 7 δευτερόλεπτα
Publication date: Available online 4 February 2016 *Source:*Journal of Bodywork and Movement Therapies Author(s): Siegfried Mense, Ulrich Hoheisel Recently, the existence of nociceptive fibers in fascia tissue has attracted much interest. Fascia can be a source of pain in several disorders such as fasciitis and non-specific low back pain. However, little is known about the properties of fascia nociceptors and possible changes of the fascia innervation by nociceptors under pathological circumstances.In this histologic study, the density of presumably nociceptive fibers and free nerve... περισσότερα »

Language Learning and Brain Reorganization In a 3.5-Year-Old Child With Left Perinatal Stroke Revealed Using Structural and Functional Connectivity

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 8 δευτερόλεπτα
Publication date: Available online 4 February 2016 *Source:*Cortex Author(s): Clément François, Pablo Ripollés, Laura Bosch, Alfredo Garcia-Alix, Jordi Muchart, Joanna Sierpowska, Carme Fons, Jorgina Solé, Monica Rebollo, Helena Gaitán, Antoni Rodriguez-Fornells Brain imaging methods have contributed to shed light on the possible mechanisms of recovery and cortical reorganization after early brain insult. The idea that a functional left hemisphere is crucial for achieving a normalized pattern of language development after left perinatal stroke is still under debate. We report the ca... περισσότερα »

The influence of baseline directional differences in pseudoneglect on distractibility

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 8 δευτερόλεπτα
Publication date: Available online 4 February 2016 *Source:*Cortex Author(s): Nicole A. Thomas, Ellie Aniulis, Michael E.R. Nicholls Neurologically normal individuals demonstrate a reliable bias to the left side of space, known as pseudoneglect. The magnitude of this attentional asymmetry varies, depending on factors such as location within the visual field. Prior research has shown that the presence of distractors in the upper visual field increase leftward biases. The current study investigated whether brief distractors in the periphery, which recruit exogenous attention influence... περισσότερα »

Granulomatosis with polyangiitis and facial palsy: Literature review and insight in the autoimmune pathogenesis

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Publication date: Available online 4 February 2016 *Source:*Autoimmunity Reviews Author(s): Giannicola Iannella, Antonio Greco, Guido Granata, Alessandra Manno, Benedetta Pasquariello, Diletta Angeletti, Dario Didona, Giuseppe Magliulo Granulomatosis with polyangiitis (GPA) is an autoimmune systemic necrotizing small-vessel vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA). Oto-neurological manifestations of ANCA associated vasculitis according to PR3-ANCA positivity and MPO-ANCA positivity are usually reported.Facial nerve palsy is usually re...περισσότερα »

A link: Allergic rhinitis, Asthma & Systemic Lupus Erythematosus

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Publication date: Available online 4 February 2016 *Source:*Autoimmunity Reviews Author(s): Eric Sin, Prachi Anand, Marianne Frieri This review has discussed a link between allergic rhinitis, asthma and systemic lupus erythematosus (SLE) and a case report in this area. A clear link with symptoms of allergic rhinitis, asthma and SLE exists. Several articles found on pubmed in the literature are listed on allergic rhinitis and allergy, Th1-immune responses, mast cells in autoimmunity, total immunoglobulin E levels in lupus, atopic diseases and SLE are reviewed. In addition, risks and ... περισσότερα »

An update on biomarkers in axial spondyloarthritis

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Publication date: Available online 4 February 2016 *Source:*Autoimmunity Reviews Author(s): Klára Prajzlerová, Kristýna Grobelná, Karel Pavelka, Ladislav Šenolt, Mária Filková Axial spondyloarthritis is a chronic inflammatory disease with the onset at a young age, and, if undiagnosed and untreated, it may result in permanent damage and lifelong disability. Rates of early diagnosis have improved, due in particular to the addition of magnetic resonance imaging into the diagnostic armamentaria; however, it is costly, not widely available, and requires experienced readers to interpret t... περισσότερα »

Survival outcomes after surgical resection of pulmonary metastases of head and neck tumours.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Survival outcomes after surgical resection of pulmonary metastases of head and neck tumours. J Laryngol Otol. 2016 Feb 3;:1-5 Authors: Hosokawa S, Funai K, Sugiyama K, Takahashi G, Okamura J, Takizawa Y, Yamatodani T, Mineta H Abstract BACKGROUND: There is limited information available regarding the benefits and outcomes of resection of pulmonary metastases arising from… Continue reading Survival outcomes after surgical resection of pulmonary metastases of head and neck tumours.

Idiopathic First Bite Syndrome

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Publication date: Available online 3 February 2016 Source:Journal of Oral and Maxillofacial Surgery Author(s): Eric T. Stoopler, Sophia Elmuradi, Thomas P. Sollectio, Natasha Mirza from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/20IoAnx via IFTTT

In Reply

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Publication date: Available online 3 February 2016 Source:Journal of Oral and Maxillofacial Surgery Author(s): Nada Alwanni, Mehmet Altay, Faisal Quereshy, Dale Baur from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Sv2Bzn via IFTTT

The compositional difference between ankle and knee cartilage demonstrated by T2 mapping at 7 Tesla MR

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Publication date: Available online 3 February 2016 Source:European Journal of Radiology Author(s): Vladimir Juras, Stefan Zbyn, Vladimir Mlynarik, Pavol Szomolanyi, Benedikt Hager, Peter Baer, Ivan Frollo, Siegfried Trattnig ObjectivesThe aim was to systematically compare T2 relaxation times of the knee and ankle cartilage within subjects at 7T.MethodsTen healthy volunteers were examined by 7 Tesla MR… Continue reading The compositional difference between ankle and knee cartilage demonstrated by T2 mapping at 7 Tesla MR

Head And Neck Cancer Squamous Cell Carcinoma Pipeline Review, H2 2015 – Research and Markets – Business Wire (press release)

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Head And Neck Cancer Squamous Cell Carcinoma Pipeline Review, H2 2015 – Research and Markets Business Wire (press release) This report provides comprehensive information on the therapeutic development for Head And Neck Cancer Squamous Cell Carcinoma, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action … and more »… Continue reading Head And Neck Cancer Squamous Cell Carcinoma Pipeline Review, H2 2015 – Research and Markets – Business Wire (press release)

Woman With Stutter Detained By U.S. Customs

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 12 δευτερόλεπτα
Last month, Kylie Simmons—a Kalamazoo College student returning from studying abroad—was detained by U.S. Customs and Border Patrol at Hartsfield-Jackson Atlanta International Airport. She was expecting to catch a connecting flight home to visit her family after her six-month stay in Costa Rica. When asked where she’d been, she stuttered on her reply and was… Continue reading Woman With Stutter Detained By U.S. Customs

Spontaneously recovered severe thrombocytopaenia following zoledronic acid infusion for osteoporosis

Spontaneously recovered severe thrombocytopaenia following zoledronic acid infusion for osteoporosis: Zoledronic acid is widely used for the treatment of various skeletal disorders. While acute phase reactions are commonly seen, hypocalcaemia, femoral shaft fractures, osteonecrosis of the jaw and renal failure are rare. Two cases of fatal thrombocytopaenic purpura have been reported following zoledronic acid infusion. […]

Opioidtherapie: Erhöhtes Frakturrisiko nicht bestätigt

Prospektive US-Studie MrOS Bei älteren Männern ist eine Opioidtherapie möglichweise nicht mit einem erhöhten Sturz- und Frakturrisiko assoziiert. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20bw5kB via IFTTT

Structure of brain plaques in Huntington’s disease described by Pitt team

Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington’s disease have a distinctive structure, a… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20sRcV3 via IFTTT

Head And Neck Cancer Squamous Cell Carcinoma Pipeline Review, H2 2015 – Research and Markets – Busine ss Wire (press release)

Head And Neck Cancer Squamous Cell Carcinoma Pipeline Review, H2 2015 – Research and Markets Business Wire (press release) This report provides comprehensive information on the therapeutic development for Head And Neck Cancer Squamous Cell Carcinoma, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action … and more » […]

Chemosensors, Vol. 4, Pages 3: Gas Sensing Studies of an n-n Hetero-Junction Array Based on SnO2 and ZnO Composites

A composite metal oxide semiconductor (MOS) sensor array based on tin dioxide (SNO2) and zinc oxide (ZnO) has been fabricated using a straight forward mechanical mixing method. The array was characterized using X-ray photoelectron spectroscopy, scanning electron microscopy, Raman spectroscopy and X-ray diffraction. The array was evaluated against a number of environmentally important reducing and […]

Beginnender Typ-2-Diabetes? Acht Fragen helfen bei der Klärung

Diabetes mellitus Millionen von Diabeteserkrankungen ließen sich verhindern. Die Instrumente dafür sind längst vorhanden. Notwendig sind ein gezieltes Screening und 10000 Schritte pro Tag. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R5xLvC via IFTTT

Extensive pneumocephalus subsequent to an open skull fracture

Extensive pneumocephalus subsequent to an open skull fracture: Description A 35-year-old man presented to the emergency department, with loss of consciousness subsequent to a fall off a wall of six-foot height. He struck his right occipital area against a short metal spike and was noted to have a small scalp laceration with a discharge of […]

Umbilical venous catheters (UVCs)

Advantages of being diligent: lessons learnt from umbilical venous catheterisation in neonates: Umbilical venous catheters (UVCs) are commonly used in neonatal units. Abdominal radiograph, taken soon after the insertion, is used to confirm the correct placement of the catheter. However, as demonstrated by our case series, complacency when an initial UVC is normally positioned can […]

Impfkalender für Kleinkinder präzisiert

STIKO Zur Grundimmunisierung sollten Kleinkinder bis zum 5. Lebensjahr nur Kombiimpfstoffe mit hohem Antigengehalt gegen Diphtherie (D) und Pertussis (aP) bekommen, berichtet die Ständige Impfkommission in einer Stellungnahme (Epi Bull 2016; 4: 31 ). Ältere Kinder könnten dazu auch Kombinationen mit niedrigem Antigengehalt (d und ap) bekommen. Diese sind eigentlich zur Auffrischung vorgesehen. Sie seien […]

Erste Kasuistik: Emetophobie bei einem jungen Mann

Sonst meist bei Frauen Ein 20-jähriger Mann steht kurz vor dem Beginn seines Studiums. Seit der Kollegstufe des Gymnasiums hat er Angst vor dem Erbrechen. An Emetophobie leiden hauptsächlich Frauen. Diese Kasuistik schildert erstmals den Krankheits- und Therapieverlauf bei einem Mann. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R5xLeU via IFTTT

Auditory risk of air rifles.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 18 δευτερόλεπτα
*Auditory risk of air rifles.* Int J Audiol. 2016 Feb;55(sup1):S51-S58 Authors: Lankford JE, Meinke DK, Flamme GA, Finan DS, Stewart M, Tasko S, Murphy WJ Abstract OBJECTIVE: To characterize the impulse noise exposure and auditory risk for air rifle users for both youth and adults. DESIGN: Acoustic characteristics were examined and the auditory risk estimates were evaluated using contemporary damage-risk criteria for unprotected adult listeners and the 120-dB peak limit and LAeq75 exposure limit suggested by the World Health Organization (1999) for children. STUDY SAMPLE: Impulses...περισσότερα »

Iodide mumps following fistulogram in a haemodialysis patient

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
Iodide mumps following fistulogram in a haemodialysis patient: Iodide mumps, or contrast-induced acute sialadenitis, is characterised by rapid, painless enlargement of the salivary glands, following the use of iodinated contrast dye. The underlying mechanism of this adverse reaction is not completely understood. It could be due to an idiosyncratic reaction or related to deposition of iodide in the ductal systems of the salivary glands causing blockage and inflammation. With increasing renal dysfunction, the elimination half-life of the iodine-containing contrast dye gets prolonged.... περισσότερα »

A 19-year-old man with long-standing neurodisability, sensorineural hearing loss and severe keratoderma, presenting with painless rapidly-progressing autoamputation of the little toe

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Hanging on by a thread: a rare case of secondary pseudoainhum: Pseudoainhum is a rare and poorly characterised phenomenon involving autoamputation of a digit associated with an identifiable or related disease process. We describe the case of a 19-year-old man with long-standing neurodisability, sensorineural hearing loss and severe keratoderma, presenting with painless rapidly-progressing autoamputation of his left little toe. Genetic analysis thus far has been inconclusive. The toe appeared to be hanging on by a thread, with no clinical signs of infection. Radiographs showed lysis... περισσότερα »

Schwannoma of cervical sympathetic chain

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
An unusual giant schwannoma of cervical sympathetic chain: a case report: Background: Schwannomas are benign, well-differentiated tumors that originate from Schwann cells. Involvement of the cervical sympathetic nerve is relatively rare. Computed tomography is indispensable for the diagnosis. The treatment is surgical. Histological examination confirms the diagnosis. Horner’s syndrome postoperatively is supportive of the diagnosis. The rarity of giant cervical sympathetic chain schwannoma made the case of our patient interesting to report. Furthermore, our patient’s immense tumor siz...περισσότερα »

Anterior Uveitis Caused by Ocular Side Effects of Afatinib

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Anterior Uveitis Caused by Ocular Side Effects of Afatinib: A Case Report: Afatinib is a second-generation epidermal growth factor receptor (EGFR) inhibitor that has been shown to be effective against *EGFR*-mutated non-small cell lung cancer (NSCLC) resistant to conventional EGFR inhibitors such as gefitinib and erlotinib. Although ocular side effects of gefitinib and erlotinib have been reported, those for afatinib have yet to be definitively established. This report presents details on the first case of unilateral iridocyclitis associated with the side effects of afatinib therapy... περισσότερα »

Spontaneously recovered severe thrombocytopaenia following zoledronic acid infusion for osteoporosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Spontaneously recovered severe thrombocytopaenia following zoledronic acid infusion for osteoporosis: Zoledronic acid is widely used for the treatment of various skeletal disorders. While acute phase reactions are commonly seen, hypocalcaemia, femoral shaft fractures, osteonecrosis of the jaw and renal failure are rare. Two cases of fatal thrombocytopaenic purpura have been reported following zoledronic acid infusion. We report a case of non-fatal thrombocytopaenia with spontaneous recovery. A 70-year woman with osteoporosis participated in a research study. Complete blood and plat... περισσότερα »

Extensive pneumocephalus subsequent to an open skull fracture

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Extensive pneumocephalus subsequent to an open skull fracture: Description A 35-year-old man presented to the emergency department, with loss of consciousness subsequent to a fall off a wall of six-foot height. He struck his right occipital area against a short metal spike and was noted to have a small scalp laceration with a discharge of clear fluid consistent with cerebrospinal fluid (CSF). His Glasgow Coma Score (GCS) was 15 on admission. A plain film radiograph of his skull demonstrated pockets of air (figure 1) and an emergent CT scan demonstrated significant pneumocephaly (fig...περισσότερα »

Umbilical venous catheters (UVCs)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα
Advantages of being diligent: lessons learnt from umbilical venous catheterisation in neonates: Umbilical venous catheters (UVCs) are commonly used in neonatal units. Abdominal radiograph, taken soon after the insertion, is used to confirm the correct placement of the catheter. However, as demonstrated by our case series, complacency when an initial UVC is normally positioned can lead to detecting UVC-related complications very late. We describe cases of three neonates where, despite the initial UVC being confirmed to be well positioned, the patients developed life-threatening comp... περισσότερα »

Cerebral infarction caused by a heart-breaking needle

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Cerebral infarction caused by a heart-breaking needle: a case report: Background: In this report, we describe a case of cerebral infarction caused by cardiac foreign body–induced infective endocarditis. We discuss the paradox of the treatment we used and highlight the need for careful examination of patients without histories and complaints of cardiac disease.Case presentationOur patient was a 48-year-old Asian woman who presented with symptoms of cerebral infarction without any characteristic features of infective endocarditis. Appropriate treatment had been delayed, which made her... περισσότερα »

Cryopyrin-associated periodic fever syndrome manifesting as Tolosa-Hunt syndrome : unilateral orbital pain, ipsilateral oculomotor paresis and a prompt response to treatment with corticosteroids

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Cryopyrin-associated periodic fever syndrome manifesting as Tolosa-Hunt syndrome: Background Tolosa-Hunt syndrome (THS) is characterized by unilateral orbital pain, ipsilateral oculomotor paresis and a prompt response to treatment with corticosteroids. Several reports have demonstrated that the clinical features of THS are not specific to one causal aetiology and can lead to misdiagnosis. Case report We report the case of a patient diagnosed with THS after an episode of unilateral orbital pain and diplopia with demonstration of granulomatous inflammation of both cavernous sinus on... περισσότερα »

Triptans became first-line anti-migraine therapies

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Twenty years of triptans in the United States Medicaid programs: Utilization and reimbursement trends from 1993 to 2013: Objective After sumatriptan was approved by the Food and Drug Administration in 1992, triptans became first-line anti-migraine therapies. Rapidly rising triptan expenditures, however, led payers, including Medicaid, to implement cost-containment policies. We describe triptan utilization and reimbursement trends in Medicaid. Methods Using national summary files for outpatient drug utilization, utilization and expenditure data from 1993 to 2013 were extracted and s...περισσότερα »

Toxins, Vol. 8, Pages 37: Cancer Therapy by Catechins Involves Redox Cycling of Copper Ions and Generation of Reactive Oxygenspecies

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
Catechins, the dietary phytochemicals present in green tea and other beverages, are considered to be potent inducers of apoptosis and cytotoxicity to cancer cells. While it is believed that the antioxidant properties of catechins and related dietary agents may contribute to lowering the risk of cancer induction by impeding oxidative injury to DNA, these properties cannot account for apoptosis induction and chemotherapeutic observations. Catechin (C), epicatechin (EC), epigallocatechin (EGC) and epigallocatechin-3-gallate (EGCG) are the four major constituents of green tea. In this... περισσότερα »

IJERPH, Vol. 13, Pages 193: Simultaneous Detection of Five Pathogens from Cerebrospinal Fluid Specimens Using Luminex Technology

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
Early diagnosis and treatment are crucial for the outcome of central nervous system (CNS) infections. In this study, we developed a multiplex PCR-Luminex assay for the simultaneous detection of five major pathogens, including Mycobacterium tuberculosis, Cryptococcus neoformans, Streptococcus pneumoniae, and herpes simplex virus types 1 and 2, which frequently cause CNS infections. Through the hybridization reaction between multiplex PCR-amplified targets and oligonucleotide "anti-TAG" sequences, we found that the PCR-Luminex assay could detect as low as 101–102 copies of synthetic... περισσότερα »

Entropy, Vol. 18, Pages 48: Thermodynamics of Quantum Feedback Cooling

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
The ability to initialize quantum registers in pure states lies at the core of many applications of quantum technologies, from sensing to quantum information processing and computation. In this paper, we tackle the problem of increasing the polarization bias of an ensemble of two-level register spins by means of joint coherent manipulations, involving a second ensemble of ancillary spins and energy dissipation into an external heat bath. We formulate this spin refrigeration protocol, akin to algorithmic cooling, in the general language of quantum feedback control, and identify the... περισσότερα »

Electronics, Vol. 5, Pages 8: FPGA Implementation of Blue Whale Calls Classifier Using High-Level Programming Tool

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
In this paper, we propose a hardware-based architecture for automatic blue whale calls classification based on short-time Fourier transform and multilayer perceptron neural network. The proposed architecture is implemented on field programmable gate array (FPGA) using Xilinx System Generator (XSG) and the Nexys-4 Artix-7 FPGA board. This high-level programming tool allows us to design, simulate and execute the compiled design in Matlab/Simulink environment quickly and easily. Intermediate signals obtained at various steps of the proposed system are presented for typical blue whale...περισσότερα »

Applied Sciences, Vol. 6, Pages 45: Wavelet Packet Decomposition to Characterize Injection Molding Tool Damage

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
This paper presents measurements of acoustic emission (AE) signals during the injection molding of polypropylene with new and damaged mold. The damaged injection mold has cracks induced by laser surface heat treatment. Standard test specimens were injection molded, commonly used for examining the shrinkage behavior of various thermoplastic materials. The measured AE burst signals during injection molding cycle are presented. For injection molding tool integrity prediction, different AE burst signals' descriptors are defined. To lower computational complexity and increase performanc...περισσότερα »

Biology, Vol. 5, Pages 10: Aboveground Net Primary Productivity in a Riparian Wetland Following Restoration of Hydrology

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
This research presents the initial results of the effects of hydrological restoration on forested wetlands in the Mississippi alluvial plain near Memphis, Tennessee. Measurements were carried out in a secondary channel, the Loosahatchie Chute, in which rock dikes were constructed in the 1960s to keep most flow in the main navigation channel. In 2008–2009, the dikes were notched to allow more flow into the secondary channel. Study sites were established based on relative distance downstream of the notched dikes. Additionally, a reference site was established north of the Loosahatch... περισσότερα »

Metals, Vol. 6, Pages 33: Monte Carlo Modelling of Single-Crystal Diffuse Scattering from Intermetallics

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
Single-crystal diffuse scattering (SCDS) reveals detailed structural insights into materials. In particular, it is sensitive to two-body correlations, whereas traditional Bragg peak-based methods are sensitive to single-body correlations. This means that diffuse scattering is sensitive to ordering that persists for just a few unit cells: nanoscale order, sometimes referred to as "local structure", which is often crucial for understanding a material and its function. Metals and alloys were early candidates for SCDS studies because of the availability of large single crystals. While... περισσότερα »

Diagnostics, Vol. 6, Pages 9: Computed Tomography and Ultrasounds for the Follow-up of Hepatocellular Carcinoma Ablation: What You Need to Know

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
Image-guided tumor ablation provides curative treatment in properly selected patients or appropriate therapeutic options whenever surgical techniques are precluded. Tumor response assessment post ablation is important in determining treatment success and future therapy. Accurate interpretation of post-ablation imaging findings is crucial for therapeutic and follow-up strategies. Computed Tomography (CT) and Ultrasound (US) play important roles in patients' follow-up post liver thermal ablation therapies. Contrast-enhanced ultrasound (CEUS) can provide valuable information on the a... περισσότερα »

Nutrients, Vol. 8, Pages 76: Exogenous Glutamine in Respiratory Diseases: Myth or Reality?

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
Several respiratory diseases feature increased inflammatory response and catabolic activity, which are associated with glutamine depletion; thus, the benefits of exogenous glutamine administration have been evaluated in clinical trials and models of different respiratory diseases. Recent reviews and meta-analyses have focused on the effects and mechanisms of action of glutamine in a general population of critical care patients or in different models of injury. However, little information is available about the role of glutamine in respiratory diseases. The aim of the present revie... περισσότερα »

Applied Sciences, Vol. 6, Pages 46: Biomedical Applications of Antibacterial Nanofiber Mats Made of Electrospinning with Wire Electrodes

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
Twisted stainless steel wires are used as wire electrodes for electrospinning the polyvinyl alcohol (PVA)/zinc citrate nanofiber mats. The morphology and diameter of the nanofibers in PVA/zinc citrate nanofiber mats are evaluated. We measured the antibacterial efficacy against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) of the nanofiber mats. We also examined the cell adhesion affinity of mammalian tissue culture cells on these nanofiber mats. Our results indicate that an increase in zinc citrate increases the viscosity and electrical conductivity of PVA solut...περισσότερα »

Econometrics, Vol. 4, Pages 7: Multiple Discrete Endogenous Variables in Weakly-Separable Triangular Models

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
We consider a model in which an outcome depends on two discrete treatment variables, where one treatment is given before the other. We formulate a three-equation triangular system with weak separability conditions. Without assuming assignment is random, we establish the identification of an average structural function using two-step matching. We also consider decomposing the effect of the first treatment into direct and indirect effects, which are shown to be identified by the proposed methodology. We allow for both of the treatment variables to be non-binary and do not appeal to ... περισσότερα »

Geriatrics, Vol. 1, Pages 6: The Older Driver with Cognitive Impairment: Perceptions of Driving Ability and Results of a Behind the Wheel Test

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
Older adult drivers with cognitive impairment pose a potential safety risk to themselves and others. Providers are often uncertain about when to request a formal evaluation of driving ability, leaving subjective reports of concerns by the patient or family as common initiators of objective driving evaluation referral. This observational study evaluated the correspondence of patient and caregiver report of driving concerns relative to objective behind-the-wheel (BTW) testing. Data were analyzed from occupational therapy driving evaluations of older adult U.S. Veterans referred from... περισσότερα »

Energies, Vol. 9, Pages 96: Elimination of the Inrush Current Phenomenon Associated with Single-Phase Offline UPS Systems

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
Critical load applications always rely on UPS systems to uphold continuous power during abnormal grid conditions. In case of any power disruption, an offline UPS system starts powering the load to avoid blackout. However, this process can root the momentous inrush current for the transformer installed before the load. The consequences of inrush current can be the reduction of output voltage and tripping of protective devices of the UPS system. Furthermore, it can also damage the sensitive load and decrease the transformer's lifetime. To prevent the inrush current, and to avoid its ... περισσότερα »

Microorganisms, Vol. 4, Pages 12: Staphylococcus aureus in Animals and Food: Methicillin Resistance, Prevalence and Population Structure. A Review in the African Continent

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
The interest about Staphylococcus aureus (S. aureus) and methicillin resistant S. aureus (MRSA) in livestock, and domestic and wild animals has significantly increased. The spread of different clonal complexes related to livestock animals, mainly CC398, and the recent description of the new mecC gene, make it necessary to know more about the epidemiology and population structure of this microorganism all over the world. Nowadays, there are several descriptions about the presence of S. aureus and/or MRSA in different animal species (dogs, sheep, donkeys, bats, pigs, and monkeys), a...περισσότερα »

Proteomes, Vol. 4, Pages 6: Proteomics of Skeletal Muscle: Focus on Insulin Resistance and Exercise Biology

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
Skeletal muscle is the largest tissue in the human body and plays an important role in locomotion and whole body metabolism. It accounts for ~80% of insulin stimulated glucose disposal. Skeletal muscle insulin resistance, a primary feature of Type 2 diabetes, is caused by a decreased ability of muscle to respond to circulating insulin. Physical exercise improves insulin sensitivity and whole body metabolism and remains one of the most promising interventions for the prevention of Type 2 diabetes. Insulin resistance and exercise adaptations in skeletal muscle might be a cause, or c...περισσότερα »

JLPEA, Vol. 6, Pages 3: An Open-Source Tool Set Enabling Analog-Digital-Software Co-Design

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
This paper presents an analog-digital hardware-software co-design environment for simulating and programming reconfigurable systems. The tool simulates, designs, as well as enables experimental measurements after compiling to configurable systems in the same integrated design tool framework. High level software in Scilab/Xcos (open-source programs similar to MATLAB/Simulink) that converts the high-level block description by the user to blif format (sci2blif), which acts as an input to the modified VPR tool, including the code v p r 2 s w c s , encoding the specific platform throug...περισσότερα »

Mathematics, Vol. 4, Pages 6: Microtubules Nonlinear Models Dynamics Investigations through the exp(−Φ(ξ))-Expansion Method Implementation

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
In this research article, we present exact solutions with parameters for two nonlinear model partial differential equations(PDEs) describing microtubules, by implementing the exp(−Φ(ξ))-Expansion Method. The considered models, describing highly nonlinear dynamics of microtubules, can be reduced to nonlinear ordinary differential equations. While the first PDE describes the longitudinal model of nonlinear dynamics of microtubules, the second one describes the nonlinear model of dynamics of radial dislocations in microtubules. The acquired solutions are then graphically presented, a...περισσότερα »

Chemosensors, Vol. 4, Pages 3: Gas Sensing Studies of an n-n Hetero-Junction Array Based on SnO2 and ZnO Composites

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
A composite metal oxide semiconductor (MOS) sensor array based on tin dioxide (SNO2) and zinc oxide (ZnO) has been fabricated using a straight forward mechanical mixing method. The array was characterized using X-ray photoelectron spectroscopy, scanning electron microscopy, Raman spectroscopy and X-ray diffraction. The array was evaluated against a number of environmentally important reducing and oxidizing gases across a range of operating temperatures (300–500 °C). The highest response achieved was against 100 ppm ethanol by the 50 wt% ZnO–50 wt% SnO2 device, which exhibited a re... περισσότερα »

IJGI, Vol. 5, Pages 11: An Assessment of Urban Surface Energy Fluxes Using a Sub-Pixel Remote Sensing Analysis: A Case Study in Suzhou, China

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 30 δευτερόλεπτα
Urban surface energy fluxes are closely associated with land-cover types (LCTs) and critical biophysical compositions. This study aims to assess the contribution of LCTs, vegetation fractional coverage (VFC) and percentage of impervious surface area (ISA%) to urban surface energy fluxes using remote sensing. An advanced urban surface energy flux algorithm was used to combine satellite imagery and meteorological station data to investigate the thermal environments in the city of Suzhou, China. The land cover abundances retrieved by multiple endmember spectral unmixing analysis (MES...περισσότερα »

A Review of Michael Stoddart.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 30 δευτερόλεπτα
*A Review of Michael Stoddart.* Chem Senses. 2016 Feb 1; Authors: Krautwurst D, Krautwurst T PMID: 26839358 [PubMed - as supplied by publisher] from #ΓεύσηΌσφρηση via ola Kala on Inoreader http://ift.tt/1nIGYOr via IFTTT

Transcriptome Analysis of Murine Olfactory Sensory Neurons during Development Using Single Cell RNA-Seq.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 30 δευτερόλεπτα
*Transcriptome Analysis of Murine Olfactory Sensory Neurons during Development Using Single Cell RNA-Seq.* Chem Senses. 2016 Feb 2; Authors: Scholz P, Kalbe B, Jansen F, Altmueller J, Becker C, Mohrhardt J, Schreiner B, Gisselmann G, Hatt H, Osterloh S Abstract Mammalian odor reception is achieved by highly specialized olfactory sensory neurons (OSNs) located in the nasal cavity. Despite their importance for the daily survival of most mammals, the gene expression and regulatory profiles of these single neurons are poorly understood. Here, we report the isolation of individual GFP...περισσότερα »

Influence of a Brazilian wild green propolis on the enamel mineral loss and Streptococcus mutans’ count in dental biofilm

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 30 δευτερόλεπτα
Publication date: Available online 3 February 2016 *Source:*Archives of Oral Biology Author(s): Julia Gabiroboertz Cardoso, Natalia Lopes Pontes Iorio, Luís Fernando Rodrigues, Maria Luiza Barra Couri, Adriana Farah, Lucianne Cople Maia, Andréa Gonçalves Antonio ObjectiveThis study investigated the anti-demineralizing and antibacterial effects of a propolis ethanolic extract (EEP) against Streptococcus mutans dental biofilm.DesignBlocks of sound bovine enamel (n=24) were fixed on polystyrene plates. S. mutans inoculum (ATCC 25175) and culture media were added (48h–37°C) to form biof...περισσότερα »

Evaluation of virulence factors of Candida albicans isolated from HIV-positive individuals using HAART

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 30 δευτερόλεπτα
Publication date: Available online 4 February 2016 *Source:*Archives of Oral Biology Author(s): Ralciane Menezes, Érika Riceto, Aércio Borges, Denise Röder, Reginaldo Pedroso The colonization by Candida species is one of the most important factors related to the development of oral candidiasis in HIV-infected individuals. The aim of the study was to evaluate and discuss the phospholipase, proteinase, DNAse and haemolytic activities of C. albicans isolated from the oral cavity of HIV individuals with high efficiency antiretroviral therapy. Seventy-five isolates of C. albicans obtaine... περισσότερα »

A new approach of the Star Excursion Balance Test to assess dynamic postural control in people complaining from chronic ankle instability

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 31 δευτερόλεπτα
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Raphaël Pionnier, Nicolas Découfour, Franck Barbier, Christophe Popineau, Emilie Simoneau-Buessinger The purpose of this study was to quantitatively and qualitatively assess dynamic balance with accuracy in individuals with chronic ankle instability (CAI). To this aim, a motion capture system was used while participants performed the Star Excursion Balance Test (SEBT). Reached distances for the 8 points of the star were automatically computed, thereby excluding any dependence to the experimenter. In addition,...περισσότερα »

A new approach of the Star Excursion Balance Test to assess dynamic postural control in people complaining from chronic ankle instability

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 31 δευτερόλεπτα
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Raphaël Pionnier, Nicolas Découfour, Franck Barbier, Christophe Popineau, Emilie Simoneau-Buessinger The purpose of this study was to quantitatively and qualitatively assess dynamic balance with accuracy in individuals with chronic ankle instability (CAI). To this aim, a motion capture system was used while participants performed the Star Excursion Balance Test (SEBT). Reached distances for the 8 points of the star were automatically computed, thereby excluding any dependence to the experimenter. In addition,...περισσότερα »

Biomechanical risk factors for tripping during obstacle—Crossing with the trailing limb in patients with type II diabetes mellitus

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 31 δευτερόλεπτα
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Wei-Chun Hsu, Ming-Wei Liu, Tung-Wu Lu People with type II diabetes mellitus (DM) are at a high risk of falling especially during more challenging locomotor tasks such as obstacle-crossing. The current study aimed to identify the risk factors for tripping in these patients during trailing-limb obstacle-crossing. Fourteen patients with type II DM with or without mild peripheral neuropathy (PN) and 14 healthy controls walked and crossed obstacles of three different heights while their motion data were measured ... περισσότερα »

Biomechanical risk factors for tripping during obstacle—Crossing with the trailing limb in patients with type II diabetes mellitus

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 31 δευτερόλεπτα
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Wei-Chun Hsu, Ming-Wei Liu, Tung-Wu Lu People with type II diabetes mellitus (DM) are at a high risk of falling especially during more challenging locomotor tasks such as obstacle-crossing. The current study aimed to identify the risk factors for tripping in these patients during trailing-limb obstacle-crossing. Fourteen patients with type II DM with or without mild peripheral neuropathy (PN) and 14 healthy controls walked and crossed obstacles of three different heights while their motion data were measured ... περισσότερα »

Estimation of foot trajectory during human walking by a wearable inertial measurement unit mounted to the foot

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 31 δευτερόλεπτα
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Naoki Kitagawa, Naomichi Ogihara To establish a supportive technology for reducing the risk of falling in older people, it is essential to clarify gait characteristics in elderly individuals that are possibly linked to the risk of falling during actual daily activities. In this study, we developed a system to monitor human gait in an outdoor environment using an inertial measurement unit consisting of a tri-axial accelerometer and tri-axial gyroscope. Step-by-step foot trajectories were estimated from the sen... περισσότερα »

Estimation of foot trajectory during human walking by a wearable inertial measurement unit mounted to the foot

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 31 δευτερόλεπτα
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Naoki Kitagawa, Naomichi Ogihara To establish a supportive technology for reducing the risk of falling in older people, it is essential to clarify gait characteristics in elderly individuals that are possibly linked to the risk of falling during actual daily activities. In this study, we developed a system to monitor human gait in an outdoor environment using an inertial measurement unit consisting of a tri-axial accelerometer and tri-axial gyroscope. Step-by-step foot trajectories were estimated from the sen... περισσότερα »

Knee contact forces are not altered in early knee osteoarthritis

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 31 δευτερόλεπτα
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): S. Meireles, F. De Groote, N.D. Reeves, S. Verschueren, C. Maganaris, F. Luyten, I. Jonkers ObjectiveThis study calculated knee contact forces (KCF) and its relations with knee external knee adduction moments (KAM) and/or flexion moments (KFM) during the stance phase of gait in patients with early osteoarthritis (OA), classified based on early joint degeneration on Magnetic Resonance Imaging (MRI). We aimed at assessing if altered KCF are already present in early structural degeneration.DesignThree-dimensiona...περισσότερα »

Pseudomigraine with transient neurological deficits and cerebrospinal fluid lymphocytosis or HaNDL syndrome: A case report with confusion and positive IgM antibodies to CMV in serum

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Pseudomigraine with transient neurological deficits and cerebrospinal fluid lymphocytosis or HaNDL syndrome: A case report with confusion and positive IgM antibodies to CMV in serum [PDF]Syndrome of Headache Accompanied with Transient ... www.noropsikiyatriarsivi.com/.../52-55.IN... - - από BOSL ve Geçici - ‎Σχετικά άρθρα 7 Ιουν 2013 - Disorders, HaNDL syndrome was defined in secondary headache group as. “Headache ... Key words: Headache, transient neurologic deficits, cerebrospinal fluid lymphocytosis ... as “pseudomigraine accompanied by lymphocytic pleocytosis ... In a...περισσότερα »

Oral leukoplakia treatment with the carbon dioxide laser

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
: A systematic review of the literature via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 4 February 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Alfonso Mogedas-Vegara, Juan-Antonio Hueto-Madrid, Eduardo Chimenos-Küstner, Coro Bescós-Atín We conducted a systematic review of the literature to evaluate treatment of oral leukoplakia with the carbon dioxide (CO2) laser.A comprehensive search of studies published between 1981 and 2015 and listed in the PubMed (National Library of Medicine, NCBI) database yielded 378... περισσότερα »

Traumatic globe dislocation into the paranasal sinuses

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
: literature review and treatment guidelines via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 4 February 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Marcio Bruno Figueiredo Amaral, André Cardoso Nery Traumatic globe dislocation into the paranasal sinuses is rare. Only 24 cases have been reported in the English-language literature indexed in PUBMED. This form of injury frequently occurs as a result of high-energy blunt trauma mainly associated to traffic accidents. Traumatic globe dislocation into the paranasal... περισσότερα »

The use of advanced airway management devices in clinical practice.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
The use of advanced airway management devices in clinical practice.:

Evaluation of double-lumen endotracheal tube extubation force by extraction angle

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Evaluation of double-lumen endotracheal tube extubation force by extraction angle: a prospective randomized clinical trial: [image: gr1.sml] Gentle and noninvasive double-lumen tracheal tube (DLT) extubation is important for both airway and circulatory management, especially after lung resection. We performed a prospective randomized clinical trial comparing DLT extubation force based on 2 different extraction angles.

Use of a bite block to manage the airway of a patient with masticatory muscle tendon-aponeurosis hyperplasia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Use of a bite block to manage the airway of a patient with masticatory muscle tendon-aponeurosis hyperplasia: [image: article_notepad.gif] Masticatory muscle tendon-aponeurosis hyperplasia (MMTAH) is characterized by limited mouth opening due to contracture of the masticatory muscles, resulting from hyperplasia of tendons and aponeuroses. Aponeurectomy of the masseter muscles and coronoidectomy may be undertaken to improve mouth opening [1]. It has been reported that tracheal intubation may be challenging in these patients, as mouth opening is not improved by neuromuscular blockad... περισσότερα »

An ETView tracheoscopic ventilation tube for placement of an EZ-Blocker without bronchoscopy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
One-lung ventilation after rapid-sequence intubation: a novel approach using an ETView tracheoscopic ventilation tube for placement of an EZ-Blocker without bronchoscopy: The ETView tracheoscopic ventilation tube (TVT) (ETView Ltd, Misgav, Israel) is a single-use tracheal tube (TT) incorporating a high-resolution imaging camera and a light source in its tip. An integrated flushing system allows efficient camera lens cleaning in situ. It is available in sizes of 7.0-, 7.5-, and 8.0-mm internal diameter, and the external structure of the ETView TVT is similar to the standard TT. The v... περισσότερα »

One-lung ventilation after rapid-sequence intubation: a novel approach using an ETView tracheoscopic ventilation tube for placement of an EZ-Blocker without bronchoscopy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
One-lung ventilation after rapid-sequence intubation: a novel approach using an ETView tracheoscopic ventilation tube for placement of an EZ-Blocker without bronchoscopy: The ETView tracheoscopic ventilation tube (TVT) (ETView Ltd, Misgav, Israel) is a single-use tracheal tube (TT) incorporating a high-resolution imaging camera and a light source in its tip. An integrated flushing system allows efficient camera lens cleaning in situ. It is available in sizes of 7.0-, 7.5-, and 8.0-mm internal diameter, and the external structure of the ETView TVT is similar to the standard TT. The v... περισσότερα »

Intravenous labetolol in treating hypertensive crisis following dexmedetomidine infusion for procedural sedation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Intravenous labetolol in treating hypertensive crisis following dexmedetomidine infusion for procedural sedation: [image: article_notepad.gif] Dexmedetomidine is widely used for procedural sedation because of its unique combination of sedation, analgesia, and anxiolysis with minimal respiratory depression. Transient hypertension has been reported during the use of dexmedetomidine which is usually benign and is taken over by the hypotensive response on continuing the infusion. We report a case of hypertensive crisis following dexmedetomidine infusion used for procedural sedation, n... περισσότερα »

Trauma-associated bleeding: management of massive transfusion.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Trauma-associated bleeding: management of massive transfusion.: Purpose of review: Early treatment goals in the bleeding trauma patient have changed based on recent research findings. Trauma patients requiring a massive transfusion protocol have shown a decreased mortality based on a more aggressive and balanced approach to blood product resuscitation. This chapter will review the recent advances in managing the bleeding trauma patient. Recent findings: Recent data have suggested a combined approach of early ratio-based blood product use, bedside viscoelastic hemostatic assays, hemo...περισσότερα »

Attenuation of High-Frequency (50-200 Hz) Thalamocortical Electroencephalographic Rhythms by Isoflurane in Rats Is More Pronounced for the Thalamus than for the Cortex.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Attenuation of High-Frequency (50-200 Hz) Thalamocortical Electroencephalographic Rhythms by Isoflurane in Rats Is More Pronounced for the Thalamus than for the Cortex.: BACKGROUND: Thalamocortical electroencephalographic rhythms in gamma (30-80 Hz) and high-gamma (80-200 Hz) ranges have been linked to arousal and conscious processes. We have recently shown that propofol causes a concentration-dependent attenuation of the power of thalamocortical rhythms in the 50 to 200 Hz range and that this effect is far more pronounced for the thalamus. To determine whether similar attenuation o... περισσότερα »

Targeting oliguria reversal in perioperative restrictive fluid management does not influence the occurrence of renal dysfunction: A systematic review and meta-analysis.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Targeting oliguria reversal in perioperative restrictive fluid management does not influence the occurrence of renal dysfunction: A systematic review and meta-analysis.: BACKGROUND: Interest in perioperative fluid restriction has increased, but it could lead to hypovolaemia. Urine output is viewed as a surrogate for renal perfusion and is frequently used to guide perioperative fluid therapy. However, the rationale behind targeting oliguria reversal - achieving and maintaining urine output above a previously defined threshold by additional fluid boluses - is often questioned. OBJECTI... περισσότερα »

Interleukins

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
*Name* *Source* [39] *Target receptors*[39][40] *Target cells*[39] *Function*[39] IL-1 macrophages, B cells,monocytes,[41]dendritic cells [41] CD121a/IL1R1, CD121b/IL1R2 T helper cells co-stimulation [41] B cells maturation & proliferation [41] NK cells activation[41] macrophages,endothelium, other inflammation,[41] small amounts induce acute phase reaction, large amounts induce fever IL-2 Th1-cells CD25/IL2RA,CD122/IL2RB,CD132/IL2RG activated[41] T cells and B cells,NK cells,macrophages,oligodendrocytes stimulates growth and differentiation of T cell response. Can be used inimmunother... περισσότερα »

The compositional difference between ankle and knee cartilage demonstrated by T2 mapping at 7 Tesla MR

Publication date: Available online 3 February 2016 Source:European Journal of Radiology Author(s): Vladimir Juras, Stefan Zbyn, Vladimir Mlynarik, Pavol Szomolanyi, Benedikt Hager, Peter Baer, Ivan Frollo, Siegfried Trattnig ObjectivesThe aim was to systematically compare T2 relaxation times of the knee and ankle cartilage within subjects at 7T.MethodsTen healthy volunteers were examined by 7 Tesla MR […]

Brain formation pattern shows why early trauma may leave no clues

Some of the earliest nerve cells to develop in the womb shape brain circuits that process sights and sounds, but then give way to mature networks that convert this sensory information into thoughts. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23KCmZd via IFTTT

In Reply

Publication date: Available online 3 February 2016 Source:Journal of Oral and Maxillofacial Surgery Author(s): Nada Alwanni, Mehmet Altay, Faisal Quereshy, Dale Baur from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1Sv2Bzn via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Plans unveiled for UK’s new global hub for cancer research and treatment https://t.co/8Gg6aN1vkU

Plans unveiled for UK’s new global hub for cancer research and treatment https://t.co/8Gg6aN1vkU from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/695198148487208960 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Aspirin-Exacerbated Respiratory Disease — New Prime Suspects

The Clinical Implications of Basic Research series has focused on highlighting laboratory research that could lead to advances in clinical therapeutics. However, the path between the laboratory and the bedside runs both ways: clinical observations often pose new questions for laboratory… from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1R54yky via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos […]

RT @being_bolder : #WorldCancerDay «I have no intention of retiring anyway because we haven’t cured cancer yet» #beatcancer @ecancer https:/…

RT @being_bolder : #WorldCancerDay «I have no intention of retiring anyway because we haven’t cured cancer yet» #beatcancer @ecancer https:/… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/695194881094979585 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

From Dancing to Debilitated

Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors’ commentary follows. Stage. A 69-year-old man sought care… from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1X57i1F via IFTTT […]

Survivor realises his dream with new Sheffield deli bar – Sheffield Telegraph

Survivor realises his dream with new Sheffield deli bar Sheffield Telegraph After beating throat cancer at the age of 21, he was determined to follow his dream. He arrived in Sheffield in search of a better life and has already used his skills to boost the food offering at three city schools. Now he is […]

A new approach of the Star Excursion Balance Test to assess dynamic postural control in people complaining from chronic ankle instability

Publication date: March 2016 Source:Gait & Posture, Volume 45 Author(s): Raphaël Pionnier, Nicolas Découfour, Franck Barbier, Christophe Popineau, Emilie Simoneau-Buessinger The purpose of this study was to quantitatively and qualitatively assess dynamic balance with accuracy in individuals with chronic ankle instability (CAI). To this aim, a motion capture system was used while participants performed the […]

Biomechanical risk factors for tripping during obstacle—Crossing with the trailing limb in patients with type II diabetes mellitus

Publication date: March 2016 Source:Gait & Posture, Volume 45 Author(s): Wei-Chun Hsu, Ming-Wei Liu, Tung-Wu Lu People with type II diabetes mellitus (DM) are at a high risk of falling especially during more challenging locomotor tasks such as obstacle-crossing. The current study aimed to identify the risk factors for tripping in these patients during trailing-limb […]

Estimation of foot trajectory during human walking by a wearable inertial measurement unit mounted to the foot

Publication date: March 2016 Source:Gait & Posture, Volume 45 Author(s): Naoki Kitagawa, Naomichi Ogihara To establish a supportive technology for reducing the risk of falling in older people, it is essential to clarify gait characteristics in elderly individuals that are possibly linked to the risk of falling during actual daily activities. In this study, we […]

Knee contact forces are not altered in early knee osteoarthritis

Publication date: March 2016 Source:Gait & Posture, Volume 45 Author(s): S. Meireles, F. De Groote, N.D. Reeves, S. Verschueren, C. Maganaris, F. Luyten, I. Jonkers ObjectiveThis study calculated knee contact forces (KCF) and its relations with knee external knee adduction moments (KAM) and/or flexion moments (KFM) during the stance phase of gait in patients with […]

Interleukin are a group of cytokines (secreted proteins and signal molecules) that were first seen to be expressed by white blood cells (leukocytes)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Interleukin *From Wikipedia, the free encyclopedia* *Interleukin are a group of cytokines (secreted proteins and signal molecules) that were first seen to be expressed by white blood cells (leukocytes).[1]* *The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiatio... περισσότερα »

The Notch Ligand DLL4 Defines a Capability of Human Dendritic Cells in Regulating Th1 and Th17 Differentiation [CLINICAL AND HUMAN IMMUNOLOGY]

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα
The Notch Ligand DLL4 Defines a Capability of Human Dendritic Cells in Regulating Th1 and Th17 Differentiation [CLINICAL AND HUMAN IMMUNOLOGY]: Notch signaling regulates multiple helper CD4+ T cell programs. We have recently demonstrated that dendritic cells (DCs) expressing the Notch ligand DLL4 are critical for eliciting alloreactive T cell responses and induction of graft-versus-host disease in mice. However, the human counterpart of murine DLL4+ DCs has yet to be examined. We report the identification of human DLL4+ DCs and their critical role in regulating Th1 and Th17 differe... περισσότερα »

Langerhans cells,Dendritic cells (DCs),Plasmacytoid dendritic cell (pDC),Myeloid dendritic cells,Conventional dendritic cells (cDC or mDC), : Altered function of dendritic cells is also known to play a major or even key role in allergy and autoimmune diseases like lupus erythematosus and inflammatory bowel diseases (Crohn's disease and ulcerative colitis).

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα
Dendritic cell From Wikipedia, the free encyclopedia *Dendritic cell* [image: Dendritic cells.jpg] Dendritic cells in skin [image: Dendritic cell revealed.jpg] Artistic rendering of the surface of a human dendritic cell illustrating sheet-like processes that fold back onto the membrane surface. When exposed toHIV, these sheets entrap viruses in the vicinity and focus them to contact zones with T cells targeted for infection. These studies were carried out using ion abrasion scanning electron microscopy, a new technology theNIH has been developing and applying for 3D cellular imaging. ... περισσότερα »

Carbon content of electricity futures in Phase II of the EU ETS

We estimate the relationship between electricity, fuel and carbon prices in Germany, France, the Netherlands, the Nord Pool market and Spain, using one-year futures for base and peakload prices for the years 2009–2012, corresponding to physical settlement during the second market phase of the EU ETS. We employ a series of estimation methods that allow […]

Toxins, Vol. 8, Pages 37: Cancer Therapy by Catechins Involves Redox Cycling of Copper Ions and Generation of Reactive Oxygenspecies

Catechins, the dietary phytochemicals present in green tea and other beverages, are considered to be potent inducers of apoptosis and cytotoxicity to cancer cells. While it is believed that the antioxidant properties of catechins and related dietary agents may contribute to lowering the risk of cancer induction by impeding oxidative injury to DNA, these properties […]

Molecular mechanism of apoptosis induction by Gaillardin, a sesquiterpene lactone, in breast cancer cell lines

Abstract Medicinal plant extracts have been widely used for cancer treatment. Gaillardin is a natural sesquiterpene lactone that has recently been reported to have anticancer properties. The ability to induce apoptosis is an important property of a candidate anticancer drug, which discriminates between anticancer drugs and toxic compounds. The current study was therefore carried out […]

Human kidney proximal tubule cells are vulnerable to the effects of Rauwolfia serpentina

Abstract Rauwolfia serpentina (or Snake root plant) is a botanical dietary supplement marketed in the USA for maintaining blood pressure. Very few studies have addressed the safety of this herb, despite its wide availability to consumers. Its reported pleiotropic effects underscore the necessity for evaluating its safety. We used a human kidney cell line to […]

Chemosensors, Vol. 4, Pages 3: Gas Sensing Studies of an n-n Hetero-Junction Array Based on SnO2 and ZnO Composites

A composite metal oxide semiconductor (MOS) sensor array based on tin dioxide (SNO2) and zinc oxide (ZnO) has been fabricated using a straight forward mechanical mixing method. The array was characterized using X-ray photoelectron spectroscopy, scanning electron microscopy, Raman spectroscopy and X-ray diffraction. The array was evaluated against a number of environmentally important reducing and […]

Evaluation of Disaster Preparedness Based on Simulation Exercises: A Comparison of Two Models

Brief Report Andres Rüter, Lisa Kurland, Dan Gryth, Jason Murphy, Monica Rådestad, Ahmadreza Djalali Disaster Medicine and Public Health Preparedness,FirstView Article(s), 5 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20IiTWK via IFTTT

Viruses, Vol. 8, Pages 39: Generation of Recombinant Polioviruses Harboring RNA Affinity Tags in the 5′ and 3′ Noncoding Regions of Genomic RNAs

Despite being intensely studied for more than 50 years, a complete understanding of the enterovirus replication cycle remains elusive. Specifically, only a handful of cellular proteins have been shown to be involved in the RNA replication cycle of these viruses. In an effort to isolate and identify additional cellular proteins that function in enteroviral RNA […]

Viruses, Vol. 8, Pages 43: To Infection and Beyond: The Multi-Pronged Anti-Cancer Mechanisms of Oncolytic Viruses

Over the past 1–2 decades we have witnessed a resurgence of efforts to therapeutically exploit the attributes of lytic viruses to infect and kill tumor cells while sparing normal cells. We now appreciate that the utility of viruses for treating cancer extends far beyond lytic cell death. Viruses are also capable of eliciting humoral and […]

Topical Issue: Acu-Obesity&Diabetes

Publication date: Available online 3 February 2016 Source:Journal of Acupuncture and Meridian Studies Author(s): Philip V. Peplow from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1S2ijRS via IFTTT

Schulungen für Ärzte zu sexualisierter Gewalt gegen Frauen

Wegen gestiegener Nachfragen Viele Frauen, die bei uns Zuflucht suchen, sind Opfer von Sexualstraftaten. Die medizinische Hilfs- und Frauenrechtsorganisation Medica Mondiale will helfen. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nIGdFl via IFTTT

PSM Peptides of Staphylococcus aureus Activate the p38-CREB Pathway in Dendritic Cells

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Thereby Modulating Cytokine Production and T Cell Priming [INFECTIOUS DISEASE AND HOST RESPONSE]: The challenging human pathogen *Staphylococcus aureus* has highly efficient immune evasion strategies for causing a wide range of diseases, from skin and soft tissue to life-threatening infections. Phenol-soluble modulin (PSM) peptides are major pathogenicity factors of community-associated methicillin-resistant *S. aureus* strains. In previous work, we demonstrated that PSMs in combination with TLR2 ligand from *S. aureus* induce tolerogenic dendritic cells (DCs) characterized by...περισσότερα »

Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells [TUMOR IMMUNOLOGY]

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells [TUMOR IMMUNOLOGY]: One of the mechanisms by which malignancies can induce immune suppression is through the production of cytokines that affect the maturation and differentiation of inflammatory cells in the tumor microenvironment. Semaphorin 4D (Sema4D) is a proangiogenic cytokine produced by several malignancies, which has been described in the regulation of the immune system. In the present study, we examined the role of human head and neck squamous cell ca... περισσότερα »

Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells [TUMOR IMMUNOLOGY]

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells [TUMOR IMMUNOLOGY]: One of the mechanisms by which malignancies can induce immune suppression is through the production of cytokines that affect the maturation and differentiation of inflammatory cells in the tumor microenvironment. Semaphorin 4D (Sema4D) is a proangiogenic cytokine produced by several malignancies, which has been described in the regulation of the immune system. In the present study, we examined the role of human head and neck squamous cell ca... περισσότερα »

Insular thyroid carcinoma (ITC) is a rare but aggressive thyroid malignancy

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Treatment and survival of patients with insular thyroid carcinoma: 508 cases from the National Cancer Data Base: Abstract Background Insular thyroid carcinoma (ITC) is a rare but aggressive thyroid malignancy. Methods Patients with ITC (*n* = 508) reported to the National Cancer Data Base from 1998 to 2012 were evaluated for patient, tumor, and treatment characteristics and outcomes. Results Compared to papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC), patients with ITC cancer were older, more often were men, had larger tumors, were more likely to present with...περισσότερα »

The SOFT trial: a Phase III study of the dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine S-1 and oxaliplatin (SOX) plus bevacizumab as first-line chemotherapy for metastatic colorectal cancer.

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
[image: http:--http://ift.tt/1TFZe7K] Related Articles *The SOFT trial: a Phase III study of the dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine S-1 and oxaliplatin (SOX) plus bevacizumab as first-line chemotherapy for metastatic colorectal cancer.* Future Oncol. 2015;11(10):1471-8 Authors: Nakamura M, Yamada Y, Muro K, Takahashi K, Baba H, Sasaki Y, Komatsu Y, Satoh T, Mishima H, Watanabe M, Sakata Y, Morita S, Shimada Y, Sugihara K Abstract A combination of oxaliplatin, leucovorin and 5-fluorouracil (FOLFOX) plus bevacizumab has been widely used for the first-line ch... περισσότερα »

Hemiscorpius lepturus venom induces expression and production of interluckin-12 in human monocytes.

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Hemiscorpius lepturus venom induces expression and production of interluckin-12 in human monocytes.* Toxicon. 2015 Jun 15;100:27-31 Authors: Hadaddezfuli R, Khodadadi A, Assarehzadegan MA, Pipelzadeh MH, Saadi S Abstract The objective of this study was to evaluate the capacity of the venom from Hemiscorpius lepturus to induce expression and production of interleukin-12 (IL-12) on isolated human monocytes. For this purpose, isolated human monocytes (250,000-300,000 cells/ml) were exposed to different concentration... περισσότερα »

Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis.

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis.* Autoimmunity. 2015 Jun;48(4):251-8 Authors: Suzuki S, Morimoto S, Fujishiro M, Kawasaki M, Hayakawa K, Miyashita T, Ikeda K, Miyazawa K, Yanagida M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y Abstract OBJECTIVE: We have shown that connective tissue growth factor (CTGF) plays an important role in the pathogenesis of rheumatoid arthritis (RA). Insulin-like growth factor binding proteins (IGFBPs) are modules of CTGF. IGFBPs bi...περισσότερα »

The presence of high-risk human papillomavirus (HPV) E6/E7 mRNA transcripts in a subset of sinonasal carcinomas is evidence of involvement of HPV in its etiopathogenesis.

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
[image: http:--production.springer.de-OnlineReso] Related Articles *The presence of high-risk human papillomavirus (HPV) E6/E7 mRNA transcripts in a subset of sinonasal carcinomas is evidence of involvement of HPV in its etiopathogenesis.* Virchows Arch. 2015 Oct;467(4):405-15 Authors: Laco J, Sieglová K, Vošmiková H, Dundr P, Němejcová K, Michálek J, Čelakovský P, Chrobok V, Mottl R, Mottlová A, Tuček L, Slezák R, Chmelařová M, Sirák I, Vošmik M, Ryška A Abstract The aim of the study was to investigate prevalence of high-risk human papillomavirus (HR-HPV) infection in sinonasal c...περισσότερα »

Improving the estimation of flavonoid intake for study of health outcomes.

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Improving the estimation of flavonoid intake for study of health outcomes.* Nutr Rev. 2015 Aug;73(8):553-76 Authors: Peterson JJ, Dwyer JT, Jacques PF, McCullough ML Abstract Imprecision in estimating intakes of non-nutrient bioactive compounds such as flavonoids is a challenge in epidemiologic studies of health outcomes. The sources of this imprecision, using flavonoids as an example, include the variability of bioactive compounds in foods due to differences in growing conditions and processing, the challenges in ... περισσότερα »

High-grade malignant transformation of a radiation-naïve nasopharyngeal angiofibroma.

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
*High-grade malignant transformation of a radiation-naïve nasopharyngeal angiofibroma.* Head Neck. 2016 Feb 3; Authors: Allensworth JJ, Troob SH, Lanciault C, Andersen PE Abstract BACKGROUND: Nasopharyngeal angiofibromas are typically considered benign vascular neoplasms, with descriptions of high-grade sarcomatous change found only in lesions with prior radiotherapy. METHODS AND RESULTS: We describe the first reported case of high-grade malignant change in a nasopharyngeal angiofibroma naive to radiation. A 45-year-old man presented with left-sided nasal congestion and fullness a... περισσότερα »

High-grade histology as predictor of early distant metastases and decreased disease-free survival in salivary gland cancer irrespective of tumor subtype.

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
*High-grade histology as predictor of early distant metastases and decreased disease-free survival in salivary gland cancer irrespective of tumor subtype.* Head Neck. 2016 Feb 3; Authors: Haderlein M, Scherl C, Semrau S, Lettmaier S, Uter W, Neukam FW, Iro H, Agaimy A, Fietkau R Abstract BACKGROUND: The purpose of this study was to evaluate risk factors that influence overall survival (OS)/disease-free survival (DFS)/locoregional recurrence-free survival (LRFS), and distant metastases-free survival (DMFS) in patients with high-risk primary salivary gland carcinoma who underwent ... περισσότερα »

The evolution of the meatal chamber in crocodyliforms

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Abstract The unique outer ear of crocodylians consists of a large meatal chamber (MC) concealed by a pair of muscular earlids that shape a large part of the animal's head. This chamber is limited medially by the enlarged tympanic membrane. Yet, the anatomy of this distinctive and complex region is underexplored and its evolutionary history untraced. The osteology and soft tissues of the MC in extant crocodylians was analysed to describe it and establish osteological correlates within this region. A broad survey of the osteological correlates was conducted in major clades of fossil ...περισσότερα »

Endothelial progenitor cells (EPC) combined with barrier membrane for the reconstruction of peri-implant osseous defects: An animal experimental study

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
The use of endothelial progenitor cells (EPC) combined with barrier membrane for the reconstruction of peri-implant osseous defects: An animal experimental study: Abstract Background The aim of this research was to study the efficacy of endothelial progenitor cells (EPC) with ß tri-calcium phosphate (ß-TCP) and barrier in the treatment of experimental periimplantitis. Methods 30 implants were placed in 5 American foxhounds. Following osseointegration, ligature-induced periimplantitis was initiated. EPC were isolated from peripheral blood. Two months later, open flap debridement was ...περισσότερα »

Periodontitis and vasculogenic erectile dysfunction

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
The association between chronic periodontitis and vasculogenic erectile dysfunction: A systematic review and meta-analysis: Abstract Aim The purpose of this systematic review and meta-analysis was to explore the association between erectile dysfunction (ED) and chronic periodontitis (CP) in observational studies. Materials and Methods A literature search of PubMed, EMBASE, and Cochrane up to and including May 22, 2015, was conducted by two independent reviewers. Statistical analysis was performed using Review Manager 5.3, and the results are expressed as odds ratios (ORs) together wi... περισσότερα »

Facial morphology in children and adolescents with juvenile idiopathic arthritis and moderate to severe temporomandibular joint involvement

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Facial morphology in children and adolescents with juvenile idiopathic arthritis and moderate to severe temporomandibular joint involvement: [image: gr1.sml] The aims of this study were to (1) assess lateral facial morphology in children and adolescents with juvenile idiopathic arthritis and moderate to severe temporomandibular joint (TMJ) involvement, (2) compare the lateral facial morphology of these subjects with and without TMJ involvement using cephalograms and 3-dimensional (3D) facial photographs, and (3) compare and correlate the results of the 3D photographic and cephalo... περισσότερα »

Occlusal and maxillofacial changes after osteochondroma extirpation

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Preoperative and postoperative examination of occlusal and maxillofacial changes after osteochondroma extirpation: [image: gr1.sml] A patient came with left-side temporomandibular arthralgia, limited mandibular opening, frontal facial asymmetry, and a significant anterolateral open bite. Severe alterations in the occlusal and maxillofacial anatomy resulted from an osteochondroma associated with the mandibular condyle. We describe the changes associated with extirpation of the mandibular condylar osteochondroma and subsequent orthodontic treatment. These clinical changes resulted...περισσότερα »

Inferior alveolar nerve lateralization and atrophied mandibles

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Implant survival and complications in cases of inferior alveolar nerve lateralization and atrophied mandibles with 5-year follow-up via Oral and Maxillofacial Surgery Publication date: Available online 3 February 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): N. Martínez-Rodríguez, C. Barona-Dorado, J. Cortes-Breton Brinkmann, M. Martín-Ares, M.I. Leco-Berrocal, J.C. Prados-Frutos, M. Peñarrocha-Diago, J.M. Martínez-González The objectives of this study were to evaluate the survival after 5 years of implants placed using inferior alveolar nerve (IAN) la... περισσότερα »

Transcriptome Analysis of Olfactory Sensory Neurons during Development Using Single Cell RNA-Seq.

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Transcriptome Analysis of Murine Olfactory Sensory Neurons during Development Using Single Cell RNA-Seq.: Chem Senses. 2016 Feb 2; Authors: Scholz P, Kalbe B, Jansen F, Altmueller J, Becker C, Mohrhardt J, Schreiner B, Gisselmann G, Hatt H, Osterloh S Abstract Mammalian odor reception is achieved by highly specialized olfactory sensory neurons (OSNs) located in the nasal cavity. Despite their importance for the daily survival of most mammals, the gene expression and regulatory profiles of these single neurons are poorly understood. Here, we report the isolation of individual GFP-l...περισσότερα »

Insular thyroid carcinoma (ITC) is a rare but aggressive thyroid malignancy

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Treatment and survival of patients with insular thyroid carcinoma: 508 cases from the National Cancer Data Base: Abstract Background Insular thyroid carcinoma (ITC) is a rare but aggressive thyroid malignancy. Methods Patients with ITC (*n* = 508) reported to the National Cancer Data Base from 1998 to 2012 were evaluated for patient, tumor, and treatment characteristics and outcomes. Results Compared to papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC), patients with ITC cancer were older, more often were men, had larger tumors, were more likely to present with ...περισσότερα »

The evolution of the meatal chamber in crocodyliforms

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Abstract The unique outer ear of crocodylians consists of a large meatal chamber (MC) concealed by a pair of muscular earlids that shape a large part of the animal’s head. This chamber is limited medially by the enlarged tympanic membrane. Yet, the anatomy of this distinctive and complex region is underexplored and its evolutionary history untraced. The osteology and soft tissues of the MC in extant crocodylians was analysed to describe it and establish osteological correlates within this region. A broad survey of the osteological correlates was conducted in major clades of fossil ...περισσότερα »

Treatment and survival of patients with insular thyroid carcinoma

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Treatment and survival of patients with insular thyroid carcinoma: 508 cases from the National Cancer Data Base: Abstract Background Insular thyroid carcinoma (ITC) is a rare but aggressive thyroid malignancy. Methods Patients with ITC (*n* = 508) reported to the National Cancer Data Base from 1998 to 2012 were evaluated for patient, tumor, and treatment characteristics and outcomes. Results Compared to papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC), patients with ITC cancer were older, more often were men, had larger tumors, were more likely to present with ...περισσότερα »

Assessment of nasal mucociliary activity in patients with Behçet's disease

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Main ArticleAssessment of nasal mucociliary activity in patients with Behçet's diseaseI Ozbaya1 c1, C Kucura1, F Temİzturka2, Y Ozkana2, C Kahramana3 and F Oghana1 a1 Department of ORL, Dumlupinar University, Kutahya, Turkey a2 Department of Physical Therapy and Rehabilitation, Dumlupinar University, Kutahya, Turkey a3 Department of Internal Medicine, Dumlupinar University, Kutahya, Turkey Abstract Objective: To investigate nasal mucociliary clearance in patients with Behçet's disease. Methods: Thirty patients with Behçet's disease, diagnosed on the basis of criteria defined by the Int... περισσότερα »

Bedside tests to predict laryngoscopic difficulty in pediatric patients : Groups by age. Weight, height, neck circumference, BMI (body mass index), inter incisors distance thyromental distance, sternomental distance, frontal plane to chin distance (FPCD) and the Mallampati index were determined and were correlated with the CML (Cormack & Lehane classification)

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
Bedside tests to predict laryngoscopic difficulty in pediatric patients via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 3 February 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): André Marques Mansano, Norma Sueli Pinheiro Módolo, Leopoldo Muniz da Silva, Eliana Maria Ganem, Leandro Gobbo Braz, Andrea de Carvalho Knabe, Fernanda Moreira de Freitas BACKGROUND AND OBJECTIVESPediatric airway management is a priority during anesthesia, critical care and emergency medicine. The purpose of this study is to validate ... περισσότερα »

DEFB1 polymorphisms and susceptibility to recurrent tonsillitis

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 1 ώρα
in Italian children via International Journal of Pediatric Otorhinolaryngology Publication date: April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Luisa Zupin, Vania Polesello, Domenico Leonardo Grasso, Sergio Crovella, Ludovica Segat IntroductionThe tonsils are secondary lymphoid organs fundamental for immune system response against pathogens within the oral cavity. Tonsillitis refers to inflammation of the pharyngeal tonsils that may include the adenoids and the lingual tonsils and that can be acute, recurrent, and chronic. Viral or bac... περισσότερα »

Immunotherapies for allergic diseases related to animal dander (other than cat, which is the most studied), such as dog, molds, occupational allergens, and insects

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Orphan immunotherapies for allergic diseases via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online 1 February 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Erminia Ridolo, Marcello Montagni, Cristoforo Incorvaia, Gianenrico Senna, Giovanni Passalacqua ObjectiveAs confirmed by systematic reviews and meta-analyses, allergen immunotherapy is clinically effective in the treatment of allergic diseases. In particular, subcutaneous immunotherapy is a pivotal treatment in patients with severe reactions to Hymenoptera venom, wh... περισσότερα »

How should occupational anaphylaxis be investigated and managed?.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
How should occupational anaphylaxis be investigated and managed?.: Purpose of review: Anaphylaxis is a systemic allergic reaction that can be life-threatening or fatal and can result from work-related exposures. This review study focuses on the assessment, main triggers, and management of occupational anaphylaxis. Recent findings: Exposed workers can be sensitized through inhalation and skin contact, and the risks increase with penetration of the allergen through the skin. The main eliciting agents of occupational anaphylaxis include stinging insects and animal bites, natural rubber ... περισσότερα »

Parents of children with food allergy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Evaluating a handbook for parents of children with food allergy: a randomized clinical trial via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online 3 February 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Jennifer S. LeBovidge, Alexis Michaud, Ashley Deleon, Laurie Harada, Susan Waserman, Lynda Schneider BackgroundEducational materials are needed to support parent management of and coping with childhood food allergy.ObjectivesTo evaluate whether a food allergy handbook can improve parental knowledge, confidence, and qua... περισσότερα »

Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change Arch Iran Med. 2016 Feb;19(2):87-91 Authors: Tafakhori A, Yu Jin Ng A, Tohari S, Venkatesh B, Lee H, Eskin A, Nelson SF, Bonnard C, Reversade B, Kariminejad A Abstract BACKGROUND: TWINKLE (c10orf2) gene is responsible for autosomal dominant progressive external ophthalmoplegia (PEO). In rare cases, additional features such as muscle weakness, peripheral neuropathy, ataxia, cardiomyopathy, dysphagia, dysphonia, cataracts, depression, dementi... περισσότερα »

Endothelial progenitor cells (EPC) combined with barrier membrane for the reconstruction of peri-implant osseous defects: An animal experimental study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
The use of endothelial progenitor cells (EPC) combined with barrier membrane for the reconstruction of peri-implant osseous defects: An animal experimental study: Abstract Background The aim of this research was to study the efficacy of endothelial progenitor cells (EPC) with ß tri-calcium phosphate (ß-TCP) and barrier in the treatment of experimental periimplantitis. Methods 30 implants were placed in 5 American foxhounds. Following osseointegration, ligature-induced periimplantitis was initiated. EPC were isolated from peripheral blood. Two months later, open flap debridement was ...περισσότερα »

Evaluating the Training Effects of Two Swallowing Rehabilitation Therapies Using Surface Electromyography-Chin Tuck Against Resistance (CTAR) Exercise and the Shaker Exercise.

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
*Evaluating the Training Effects of Two Swallowing Rehabilitation Therapies Using Surface Electromyography-Chin Tuck Against Resistance (CTAR) Exercise and the Shaker Exercise.* Dysphagia. 2016 Feb 2; Authors: Sze WP, Yoon WL, Escoffier N, Rickard Liow SJ Abstract In this study, the efficacy of two dysphagia interventions, the Chin Tuck against Resistance (CTAR) and Shaker exercises, were evaluated based on two principles in exercise science-muscle-specificity and training intensity. Both exercises were developed to strengthen the suprahyoid muscles, whose contractions facilitate...περισσότερα »

Molecular mechanism of apoptosis induction by Gaillardin, a sesquiterpene lactone, in breast cancer cell lines

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Medicinal plant extracts have been widely used for cancer treatment. Gaillardin is a natural sesquiterpene lactone that has recently been reported to have anticancer properties. The ability to induce apoptosis is an important property of a candidate anticancer drug, which discriminates between anticancer drugs and toxic compounds. The current study was therefore carried out to address the issue if Gaillardin is able to induce apoptosis in the breast cancer cell lines MCF-7 and MDA-MB-468 and to determine the underlying mechanism of its anticancer effects. Apoptosis induct... περισσότερα »

Extranodal natural killer/T cell lymphoma: we should and we can do more.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--http://ift.tt/1Pkbci8] Related Articles *Extranodal natural killer/T cell lymphoma: we should and we can do more.* Chin Clin Oncol. 2015 Mar;4(1):12 Authors: Ying Z, Zhu J Abstract Extranodal natural killer/T cell lymphoma, nasal type (ENKL) is a rare disease, which is much more prevalent in Asia. With the advent of L-asparaginase-based regimen, the outcome of ENKL was improved obviously. Sequential chemotherapy and radiotherapy is the standard treatment for early-stage ENKL. However, the outcome of advanced-stage diseases is not satisfactory. Therefore, risk-strat... περισσότερα »

Successful treatment with alectinib after crizotinib-induced esophageal ulceration.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Successful treatment with alectinib after crizotinib-induced esophageal ulceration.* Lung Cancer. 2015 Jun;88(3):349-51 Authors: Yoneshima Y, Okamoto I, Takano T, Enokizu A, Iwama E, Harada T, Takayama K, Nakanishi Y Abstract Crizotinib was the first clinically available inhibitor of the tyrosine kinase ALK, and next-generation ALK inhibitors, such as alectinib, are now under development. Although crizotinib is generally well tolerated, severe esophageal injury has been reported as a rare but serious adverse even... περισσότερα »

Barriers and facilitators to establishing a national public health observatory.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Barriers and facilitators to establishing a national public health observatory.* Rev Panam Salud Publica. 2015 Nov;38(5):403-9 Authors: Pooransingh S, Misir A, Ramdath D, Ramsewak S, Jaglal S, Cameron C, Goel V Abstract OBJECTIVE: To determine what stakeholders perceive as barriers and facilitators to creating a national public health observatory (PHO) in Trinidad and Tobago. METHODS: A descriptive study was conducted based on 15 key informant interviews carried out from April to September 2013. The key informants worked within the health care sector in Trinidad and Tobago. Usin... περισσότερα »

Lucy Montoro Rehabilitation Network mobile unit: an alternative public healthcare policy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Lucy Montoro Rehabilitation Network mobile unit: an alternative public healthcare policy.* Disabil Rehabil Assist Technol. 2015 Jul;10(4):309-15 Authors: Battistella LR, Juca SS, Tateishi M, Oshiro MS, Yamanaka EI, Lima E, Ramos VD Abstract PURPOSE: The aim is to analyze rehabilitation services provided by a mobile rehabilitation clinic (MU) in nine regions of the State of São Paulo, demonstrating the distribution of orthoses, prostheses and other mobility aids for persons with physical disabilities according to age groups a... περισσότερα »

Comparison between performances of three types of manual wheelchairs often distributed in low-resource settings.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Comparison between performances of three types of manual wheelchairs often distributed in low-resource settings.* Disabil Rehabil Assist Technol. 2015 Jul;10(4):316-22 Authors: Rispin K, Wee J Abstract PURPOSE: This study was conducted to compare the performance of three types of chairs in a low-resource setting. The larger goal was to provide information which will enable more effective use of limited funds by wheelchair manufacturers and suppliers in low-resource settings. METHODS: The Motivation Rough Terrain and Whirlwind...περισσότερα »

Using SMS as a tool to reduce exclusions experienced by caregivers of people with disabilities in a resource-limited Colombian community.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Using SMS as a tool to reduce exclusions experienced by caregivers of people with disabilities in a resource-limited Colombian community.* Disabil Rehabil Assist Technol. 2015 Jul;10(4):347-54 Authors: Barlott T, Adams K, Díaz FR, Molina MM Abstract PURPOSE: The community of El Codito, located in the mountainside on the perimeter of Bogota, Colombia, is considered one of the most vulnerable and resource-limited communities in the region. This community-based research (CBR) project used short message service (SMS) messaging as... περισσότερα »

Convention on the rights of persons with disabilities, assistive technology and information and communication technology requirements: where do we stand on implementation?

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Convention on the rights of persons with disabilities, assistive technology and information and communication technology requirements: where do we stand on implementation?* Disabil Rehabil Assist Technol. 2015 Jul;10(4):295-300 Authors: Gould M, Leblois A, Cesa Bianchi F, Montenegro V Abstract PURPOSE: This article presents 2013 data from a survey provided by G3ict and Disabled Peoples International (DPI). The Progress Report identifies the degree that each of the CRPD dispositions on ATs and ICTs accessibility are enacted i...περισσότερα »

Mobile devices and weak ties: a study of vision impairments and workplace access in Bangalore.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Mobile devices and weak ties: a study of vision impairments and workplace access in Bangalore.* Disabil Rehabil Assist Technol. 2015 Jul;10(4):323-31 Authors: Pal J, Lakshmanan M Abstract PURPOSE: To explore ways in which social and economic interactions are changed by access to mobile telephony. METHOD: This is a mixed-methods study of mobile phone use among 52 urban professionals with vision impairments in Bangalore, India. RESULTS: Interviews and survey results indicated that mobile devices, specifically those with adaptiv... περισσότερα »

Users' perspectives on the provision of assistive technologies in Bangladesh: awareness, providers, costs and barriers.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Users' perspectives on the provision of assistive technologies in Bangladesh: awareness, providers, costs and barriers.* Disabil Rehabil Assist Technol. 2015 Jul;10(4):301-8 Authors: Borg J, Östergren PO Abstract PURPOSE: The purpose of this work was to contribute to a better understanding of challenges and solutions to equitable provision of assistive technologies in resource limited environments by (i) describing sources of awareness, types of providers and costs of assistive technologies; (ii) describing common reasons fo... περισσότερα »

Eye gaze technology: a South African perspective.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Eye gaze technology: a South African perspective.* Disabil Rehabil Assist Technol. 2015 Jul;10(4):340-6 Authors: van Niekerk K, Tönsing K Abstract PURPOSE: Based on the bioecological model by Bronfenbrenner, this paper will provide a broad perspective on factors that need to be taken into account in order to facilitate communication and participation in preliterate children making use of electronic Augmentative and Alternative Communication (AAC) systems accessed through eye gaze. METHOD: Two case studies of children who have...περισσότερα »

The use of mobile devices as assistive technology in resource-limited environments: access for learners with visual impairments in Kenya.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *The use of mobile devices as assistive technology in resource-limited environments: access for learners with visual impairments in Kenya.* Disabil Rehabil Assist Technol. 2015 Jul;10(4):332-9 Authors: Foley AR, Masingila JO Abstract PURPOSE: In this paper, the authors explore the use of mobile devices as assistive technology for students with visual impairments in resource-limited environments. This paper provides initial data and analysis from an ongoing project in Kenya using tablet devices to provide access to education a... περισσότερα »

Literature review on monitoring technologies and their outcomes in independently living elderly people.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Literature review on monitoring technologies and their outcomes in independently living elderly people.* Disabil Rehabil Assist Technol. 2015 Jul;10(4):271-94 Authors: Peetoom KK, Lexis MA, Joore M, Dirksen CD, De Witte LP Abstract PURPOSE: To obtain insight into what kind of monitoring technologies exist to monitor activity in-home, what the characteristics and aims of applying these technologies are, what kind of research has been conducted on their effects and what kind of outcomes are reported. METHODS: A systematic docum... περισσότερα »

PET/MR - a rapidly growing technique of imaging in oncology and neurology.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*PET/MR - a rapidly growing technique of imaging in oncology and neurology.* Nucl Med Rev Cent East Eur. 2016;19(1):37-41 Authors: Sałyga A, Guzikowska-Ruszkowska I, Czepczyński R, Ruchała M Abstract INTRODUCTION: The combination of positron emission tomography (PET) and magnetic resonance (MR) has become a subject of interest for researchers in the recent several years. Positron emission tomography in combination with magnetic resonance (PET/MR) is the most recent imaging technique classified in the so called hybrid systems category. AIM: This review briefly discusses the developm... περισσότερα »

Frequent Emergency Department Utilizers Among Children with Cancer.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Frequent Emergency Department Utilizers Among Children with Cancer.* Pediatr Blood Cancer. 2016 Feb 3; Authors: Mueller EL, Hall M, Carroll AE, Shah SS, Macy ML Abstract BACKGROUND: Pediatric frequent emergency department (ED) utilizers contribute a significant proportion of ED visits, but no studies specifically address children with cancer. METHODS: A retrospective study of Pediatric Health Information System analyzing ED visits for children with cancer, including ED visits within 365 days from the first inpatient encounter with a discharge diagnosis code for malignancy. We def... περισσότερα »

The Promise of Chimeric Antigen Receptor Engineered T Cells in the Treatment of Hematologic Malignancies.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*The Promise of Chimeric Antigen Receptor Engineered T Cells in the Treatment of Hematologic Malignancies.* Cancer J. 2016 Jan-Feb;22(1):27-33 Authors: Nagle SJ, Garfall AL, Stadtmauer EA Abstract Relapsed and refractory hematologic malignancies have a very poor prognosis. Chimeric antigen receptor T cells are emerging as a powerful therapy in this setting. Early clinical trials of genetically modified T cells for the treatment of non-Hodgkin lymphoma, chronic lymphocytic leukemia, and acute lymphoblastic leukemia have shown high complete response rates in patients with few thera...περισσότερα »

The presence of high-risk human papillomavirus (HPV) E6/E7 mRNA transcripts in a subset of sinonasal carcinomas is evidence of involvement of HPV in its etiopathogenesis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
[image: http:--production.springer.de-OnlineReso] Related Articles *The presence of high-risk human papillomavirus (HPV) E6/E7 mRNA transcripts in a subset of sinonasal carcinomas is evidence of involvement of HPV in its etiopathogenesis.* Virchows Arch. 2015 Oct;467(4):405-15 Authors: Laco J, Sieglová K, Vošmiková H, Dundr P, Němejcová K, Michálek J, Čelakovský P, Chrobok V, Mottl R, Mottlová A, Tuček L, Slezák R, Chmelařová M, Sirák I, Vošmik M, Ryška A Abstract The aim of the study was to investigate prevalence of high-risk human papillomavirus (HR-HPV) infection in sinonasal ...περισσότερα »

The evolution of the meatal chamber in crocodyliforms

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
Abstract The unique outer ear of crocodylians consists of a large meatal chamber (MC) concealed by a pair of muscular earlids that shape a large part of the animal's head. This chamber is limited medially by the enlarged tympanic membrane. Yet, the anatomy of this distinctive and complex region is underexplored and its evolutionary history untraced. The osteology and soft tissues of the MC in extant crocodylians was analysed to describe it and establish osteological correlates within this region. A broad survey of the osteological correlates was conducted in major clades of fossil ...περισσότερα »

The evolution of the meatal chamber in crocodyliforms

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract The unique outer ear of crocodylians consists of a large meatal chamber (MC) concealed by a pair of muscular earlids that shape a large part of the animal's head. This chamber is limited medially by the enlarged tympanic membrane. Yet, the anatomy of this distinctive and complex region is underexplored and its evolutionary history untraced. The osteology and soft tissues of the MC in extant crocodylians was analysed to describe it and establish osteological correlates within this region. A broad survey of the osteological correlates was conducted in major clades of fossil ...περισσότερα »

Periodontitis and vasculogenic erectile dysfunction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
The association between chronic periodontitis and vasculogenic erectile dysfunction: A systematic review and meta-analysis: Abstract Aim The purpose of this systematic review and meta-analysis was to explore the association between erectile dysfunction (ED) and chronic periodontitis (CP) in observational studies. Materials and Methods A literature search of PubMed, EMBASE, and Cochrane up to and including May 22, 2015, was conducted by two independent reviewers. Statistical analysis was performed using Review Manager 5.3, and the results are expressed as odds ratios (ORs) together w... περισσότερα »

Facial morphology in children and adolescents with juvenile idiopathic arthritis and moderate to severe temporomandibular joint involvement

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Facial morphology in children and adolescents with juvenile idiopathic arthritis and moderate to severe temporomandibular joint involvement: [image: gr1.sml] The aims of this study were to (1) assess lateral facial morphology in children and adolescents with juvenile idiopathic arthritis and moderate to severe temporomandibular joint (TMJ) involvement, (2) compare the lateral facial morphology of these subjects with and without TMJ involvement using cephalograms and 3-dimensional (3D) facial photographs, and (3) compare and correlate the results of the 3D photographic and cephal... περισσότερα »

Occlusal and maxillofacial changes after osteochondroma extirpation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Preoperative and postoperative examination of occlusal and maxillofacial changes after osteochondroma extirpation: [image: gr1.sml] A patient came with left-side temporomandibular arthralgia, limited mandibular opening, frontal facial asymmetry, and a significant anterolateral open bite. Severe alterations in the occlusal and maxillofacial anatomy resulted from an osteochondroma associated with the mandibular condyle. We describe the changes associated with extirpation of the mandibular condylar osteochondroma and subsequent orthodontic treatment. These clinical changes resulte... περισσότερα »

Inferior alveolar nerve lateralization and atrophied mandibles

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Implant survival and complications in cases of inferior alveolar nerve lateralization and atrophied mandibles with 5-year follow-up via Oral and Maxillofacial Surgery Publication date: Available online 3 February 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): N. Martínez-Rodríguez, C. Barona-Dorado, J. Cortes-Breton Brinkmann, M. Martín-Ares, M.I. Leco-Berrocal, J.C. Prados-Frutos, M. Peñarrocha-Diago, J.M. Martínez-González The objectives of this study were to evaluate the survival after 5 years of implants placed using inferior alveolar nerve (IAN) la... περισσότερα »

Transcriptome Analysis of Olfactory Sensory Neurons during Development Using Single Cell RNA-Seq.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Transcriptome Analysis of Murine Olfactory Sensory Neurons during Development Using Single Cell RNA-Seq.: Chem Senses. 2016 Feb 2; Authors: Scholz P, Kalbe B, Jansen F, Altmueller J, Becker C, Mohrhardt J, Schreiner B, Gisselmann G, Hatt H, Osterloh S Abstract Mammalian odor reception is achieved by highly specialized olfactory sensory neurons (OSNs) located in the nasal cavity. Despite their importance for the daily survival of most mammals, the gene expression and regulatory profiles of these single neurons are poorly understood. Here, we report the isolation of individual GFP-l...περισσότερα »

Treatment and survival of patients with insular thyroid carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Treatment and survival of patients with insular thyroid carcinoma: 508 cases from the National Cancer Data Base: Abstract Background Insular thyroid carcinoma (ITC) is a rare but aggressive thyroid malignancy. Methods Patients with ITC (*n* = 508) reported to the National Cancer Data Base from 1998 to 2012 were evaluated for patient, tumor, and treatment characteristics and outcomes. Results Compared to papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC), patients with ITC cancer were older, more often were men, had larger tumors, were more likely to present with...περισσότερα »

The evolution of the meatal chamber in crocodyliforms

Abstract The unique outer ear of crocodylians consists of a large meatal chamber (MC) concealed by a pair of muscular earlids that shape a large part of the animal’s head. This chamber is limited medially by the enlarged tympanic membrane. Yet, the anatomy of this distinctive and complex region is underexplored and its evolutionary history […]

Assessment of nasal mucociliary activity in patients with Behçet's disease

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Main ArticleAssessment of nasal mucociliary activity in patients with Behçet's diseaseI Ozbaya1 c1, C Kucura1, F Temİzturka2, Y Ozkana2, C Kahramana3 and F Oghana1 a1 Department of ORL, Dumlupinar University, Kutahya, Turkey a2 Department of Physical Therapy and Rehabilitation, Dumlupinar University, Kutahya, Turkey a3 Department of Internal Medicine, Dumlupinar University, Kutahya, Turkey Abstract Objective: To investigate nasal mucociliary clearance in patients with Behçet's disease. Methods: Thirty patients with Behçet's disease, diagnosed on the basis of criteria defined by the Int... περισσότερα »

Bedside tests to predict laryngoscopic difficulty in pediatric patients : Groups by age. Weight, height, neck circumference, BMI (body mass index), inter incisors distance thyromental distance, sternomental distance, frontal plane to chin distance (FPCD) and the Mallampati index were determined and were correlated with the CML (Cormack & Lehane classification)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Bedside tests to predict laryngoscopic difficulty in pediatric patients via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 3 February 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): André Marques Mansano, Norma Sueli Pinheiro Módolo, Leopoldo Muniz da Silva, Eliana Maria Ganem, Leandro Gobbo Braz, Andrea de Carvalho Knabe, Fernanda Moreira de Freitas BACKGROUND AND OBJECTIVESPediatric airway management is a priority during anesthesia, critical care and emergency medicine. The purpose of this study is to validate ... περισσότερα »

DEFB1 polymorphisms and susceptibility to recurrent tonsillitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
in Italian children via International Journal of Pediatric Otorhinolaryngology Publication date: April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Luisa Zupin, Vania Polesello, Domenico Leonardo Grasso, Sergio Crovella, Ludovica Segat IntroductionThe tonsils are secondary lymphoid organs fundamental for immune system response against pathogens within the oral cavity. Tonsillitis refers to inflammation of the pharyngeal tonsils that may include the adenoids and the lingual tonsils and that can be acute, recurrent, and chronic. Viral or bac... περισσότερα »

The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
in a rat model via Oral Biology Publication date: Available online 3 February 2016 *Source:*Archives of Oral Biology Author(s): Suzuro Hitomi, Ono Kentaro, Kiichiro Yamaguchi, Kiyoshi Terawaki, Ryota Imai, Kunitsugu Kubota, Yuji Omiya, Tomohisa Hattori, Yoshio Kase, Kiyotoshi Inenaga ObjectiveRecent studies have demonstrated that mouthwash made with the traditional Japanese medicine hangeshashinto exhibits anti-inflammatory action and alleviates oral mucositis scores, including pain complaints, in patients undergoing chemoradiotherapy. However, no study has demonstrated the mechanism... περισσότερα »

Human Neutrophil Peptide-1 Affects Matrix Metalloproteinase-2, -8 and -9 Secretions of Oral Squamous Cell Carcinoma Cell Lines

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Human Neutrophil Peptide-1 Affects Matrix Metalloproteinase-2, -8 and -9 Secretions of Oral Squamous Cell Carcinoma Cell Lines in vitro via Oral Biology Publication date: Available online 4 February 2016 *Source:*Archives of Oral Biology Author(s): Ahmed Ali Musrati, Taina Tervahartiala, Mervi Gürsoy, Eija Könönen, Dareen Fteita, Timo Sorsa, Veli-Jukka Uitto, Ulvi Kahraman Gürsoy ObjectivesThe present study aimed to investigate the effect of HNP-1 on the matrix metalloproteinase (MMP)-2, -8 and -9 secretions of two oral squamous cell carcinoma (OSCC) cell lines (UT-SCC-43A and UT-SCC-43...περισσότερα »

Virulence factors of Candida albicans

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Evaluation of virulence factors of Candida albicans isolated from HIV-positive individuals using HAART via Oral Biology Publication date: Available online 4 February 2016 *Source:*Archives of Oral Biology Author(s): Ralciane Menezes, Érika Riceto, Aércio Borges, Denise Röder, Reginaldo Pedroso The colonization by Candida species is one of the most important factors related to the development of oral candidiasis in HIV-infected individuals. The aim of the study was to evaluate and discuss the phospholipase, proteinase, DNAse and haemolytic activities of C. albicans isolated from the or... περισσότερα »

Human Neutrophil Peptide-1 Affects Matrix Metalloproteinase-2, -8 and -9 Secretions of Oral Squamous Cell Carcinoma Cell Lines

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
in vitro via Oral Biology Publication date: Available online 4 February 2016 *Source:*Archives of Oral Biology Author(s): Ahmed Ali Musrati, Taina Tervahartiala, Mervi Gürsoy, Eija Könönen, Dareen Fteita, Timo Sorsa, Veli-Jukka Uitto, Ulvi Kahraman Gürsoy ObjectivesThe present study aimed to investigate the effect of HNP-1 on the matrix metalloproteinase (MMP)-2, -8 and -9 secretions of two oral squamous cell carcinoma (OSCC) cell lines (UT-SCC-43A and UT-SCC-43B).DesignIn all experiments, the two OSCC cell lines were incubated with graded concentrations (0, 1, 5, and 10μg/ml) of HNP-... περισσότερα »

Wild green propolis on the enamel mineral loss and Streptococcus mutans’ count in dental biofilm

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Influence of a Brazilian via Oral Biology Publication date: Available online 3 February 2016 *Source:*Archives of Oral Biology Author(s): Julia Gabiroboertz Cardoso, Natalia Lopes Pontes Iorio, Luís Fernando Rodrigues, Maria Luiza Barra Couri, Adriana Farah, Lucianne Cople Maia, Andréa Gonçalves Antonio ObjectiveThis study investigated the anti-demineralizing and antibacterial effects of a propolis ethanolic extract (EEP) against Streptococcus mutans dental biofilm.DesignBlocks of sound bovine enamel (n=24) were fixed on polystyrene plates. S. mutans inoculum (ATCC 25175) and culture ...περισσότερα »

Tripping during obstacle

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Biomechanical risk factors for tripping during obstacle—Crossing with the trailing limb in patients with type II diabetes mellitus via Gait & Posture Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Wei-Chun Hsu, Ming-Wei Liu, Tung-Wu Lu People with type II diabetes mellitus (DM) are at a high risk of falling especially during more challenging locomotor tasks such as obstacle-crossing. The current study aimed to identify the risk factors for tripping in these patients during trailing-limb obstacle-crossing. Fourteen patients with type II DM with or without mil... περισσότερα »

The Star Excursion Balance Test (SEBT) : Dynamic postural control

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
A new approach of the Star Excursion Balance Test to assess dynamic postural control in people complaining from chronic ankle instability via Gait & Posture Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Raphaël Pionnier, Nicolas Découfour, Franck Barbier, Christophe Popineau, Emilie Simoneau-Buessinger The purpose of this study was to quantitatively and qualitatively assess dynamic balance with accuracy in individuals with chronic ankle instability (CAI). To this aim, a motion capture system was used while participants performed the Star Excursion Balance T... περισσότερα »

Knee contact forces are not altered in early knee osteoarthritis

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 1 ώρα
Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): S. Meireles, F. De Groote, N.D. Reeves, S. Verschueren, C. Maganaris, F. Luyten, I. Jonkers ObjectiveThis study calculated knee contact forces (KCF) and its relations with knee external knee adduction moments (KAM) and/or flexion moments (KFM) during the stance phase of gait in patients with early osteoarthritis (OA), classified based on early joint degeneration on Magnetic Resonance Imaging (MRI). We aimed at assessing if altered KCF are already present in early structural degeneration.DesignThree-dimensiona...περισσότερα »

Analytical evaluation of the effects of inconsistent anthropometric measurements on joint kinematics in motion capturing

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 1 ώρα
Publication date: Available online 3 February 2016 *Source:*Gait & Posture Author(s): Dominik Krumm, John Cockcroft, Falk Zaumseil, Stephan Odenwald, Thomas L. Milani, Quinette Louw Clinical decisions based on gait data obtained by optoelectronic motion capturing require profound knowledge about the repeatability of the used measurement systems and methods. The purpose of this study was to evaluate the effects of inconsistent anthropometric measurements on joint kinematics calculated with the Plug-in Gait model. Therefore, a sensitivity study was conducted to ascertain how joint kin... περισσότερα »

Analytical evaluation of the effects of inconsistent anthropometric measurements on joint kinematics in motion capturing

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 1 ώρα
Publication date: Available online 3 February 2016 *Source:*Gait & Posture Author(s): Dominik Krumm, John Cockcroft, Falk Zaumseil, Stephan Odenwald, Thomas L. Milani, Quinette Louw Clinical decisions based on gait data obtained by optoelectronic motion capturing require profound knowledge about the repeatability of the used measurement systems and methods. The purpose of this study was to evaluate the effects of inconsistent anthropometric measurements on joint kinematics calculated with the Plug-in Gait model. Therefore, a sensitivity study was conducted to ascertain how joint kin... περισσότερα »

Auditory risk of air rifles.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 1 ώρα
*Auditory risk of air rifles.* Int J Audiol. 2016 Feb;55(sup1):S51-S58 Authors: Lankford JE, Meinke DK, Flamme GA, Finan DS, Stewart M, Tasko S, Murphy WJ Abstract OBJECTIVE: To characterize the impulse noise exposure and auditory risk for air rifle users for both youth and adults. DESIGN: Acoustic characteristics were examined and the auditory risk estimates were evaluated using contemporary damage-risk criteria for unprotected adult listeners and the 120-dB peak limit and LAeq75 exposure limit suggested by the World Health Organization (1999) for children. STUDY SAMPLE: Impulses...περισσότερα »

A 32-channel head coil and a 2-channel surface coil for MR imaging of the temporomandibular joint at 3.0 Tesla.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Comparison of a 32-channel head coil and a 2-channel surface coil for MR imaging of the temporomandibular joint at 3.0 Tesla Dentomaxillofac Radiol. 2016 Feb 3;:20150420 Authors: Manoliu A, Spinner G, Wyss M, Filli L, Erni S, Ettlin DA, Ulbrich EJ, Kuhn FP, Gallo LM, Andreisek G Abstract PURPOSE: To quantitatively and qualitatively compare MR imaging of the temporomandibular joint (TMJ) using a standard TMJ surface coil and a head coil at 3.0 Tesla (T). MATERIALS AND METHODS: Twenty-two asymptomatic volunteers were MR-imaged using a 2-channel surface coil (standard TMJ coil) and a... περισσότερα »

Letter: gluten challenge in the era of noncoeliac gluten sensitivity – a change in clinical practice? Author's reply

Alexandros G. SfakianakisστοThe OesophagusΠριν από 1 ώρα
from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/1Qe1UUy via IFTTT

Letter: effectiveness of golimumab to induce remission in outpatient ulcerative colitis in Italy

Alexandros G. SfakianakisστοThe OesophagusΠριν από 1 ώρα
from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/1JZplV7 via IFTTT

Editorial: how to interpret risks and prediction of complications in Crohn's disease – can our patients interpret them? Authors' reply

Alexandros G. SfakianakisστοThe OesophagusΠριν από 1 ώρα
from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/1Qe1WvS via IFTTT

Letter: nucleos(t)ide analogues are good, but not sufficient for hepatitis B virus clearance – author's reply

Alexandros G. SfakianakisστοThe OesophagusΠριν από 1 ώρα
from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/1Qe0fOW via IFTTT

Optimizing Human Bile Preparation for Two-Dimensional Gel Electrophoresis

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Aims. Bile is an important body fluid which assists in the digestion of fat and excretion of endogenous and exogenous compounds. In the present study, an improved sample preparation for human bile was established. Methods and Material. The method involved acetone precipitation followed by protein extraction using commercially available 2D Clean-Up kit. The effectiveness was evaluated by 2-dimensional electrophoresis (2DE) profiling quality, including number of protein spots and spot distribution. Results. The total protein of bile fluid in benign biliary disorders was 0.797 ± 0.465... περισσότερα »

Human Neutrophil Peptide-1 Affects Matrix Metalloproteinase-2, -8 and -9 Secretions of Oral Squamous Cell Carcinoma Cell Lines in vitro

Publication date: Available online 4 February 2016 *Source:*Archives of Oral Biology Author(s): Ahmed Ali Musrati, Taina Tervahartiala, Mervi Gürsoy, Eija Könönen, Dareen Fteita, Timo Sorsa, Veli-Jukka Uitto, Ulvi Kahraman Gürsoy ObjectivesThe present study aimed to investigate the effect of HNP-1 on the matrix metalloproteinase (MMP)-2, -8 and -9 secretions of two oral squamous cell carcinoma (OSCC) cell lines (UT-SCC-43A and UT-SCC-43B).DesignIn all experiments, the two OSCC cell lines were incubated with graded concentrations (0, 1, 5, and 10μg/ml) of HNP-1 for 24 and 48h. Cell v... περισσότερα »

The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model

Publication date: Available online 3 February 2016 *Source:*Archives of Oral Biology Author(s): Suzuro Hitomi, Ono Kentaro, Kiichiro Yamaguchi, Kiyoshi Terawaki, Ryota Imai, Kunitsugu Kubota, Yuji Omiya, Tomohisa Hattori, Yoshio Kase, Kiyotoshi Inenaga ObjectiveRecent studies have demonstrated that mouthwash made with the traditional Japanese medicine hangeshashinto exhibits anti-inflammatory action and alleviates oral mucositis scores, including pain complaints, in patients undergoing chemoradiotherapy. However, no study has demonstrated the mechanism underlying how hangeshashinto ...περισσότερα »

Multidisciplinary Clinical Case Study.

Multidisciplinary Clinical Case Study. South Med J. 2016 Feb;109(2):77 Authors: Holt GR PMID: 26840959 [PubMed – as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1NRMKCR via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Pk1zQs via IFTTT

PET/MR – a rapidly growing technique of imaging in oncology and neurology.

PET/MR – a rapidly growing technique of imaging in oncology and neurology. Nucl Med Rev Cent East Eur. 2016;19(1):37-41 Authors: Sałyga A, Guzikowska-Ruszkowska I, Czepczyński R, Ruchała M Abstract INTRODUCTION: The combination of positron emission tomography (PET) and magnetic resonance (MR) has become a subject of interest for researchers in the recent several years. Positron […]

Frequent Emergency Department Utilizers Among Children with Cancer.

Frequent Emergency Department Utilizers Among Children with Cancer. Pediatr Blood Cancer. 2016 Feb 3; Authors: Mueller EL, Hall M, Carroll AE, Shah SS, Macy ML Abstract BACKGROUND: Pediatric frequent emergency department (ED) utilizers contribute a significant proportion of ED visits, but no studies specifically address children with cancer. METHODS: A retrospective study of Pediatric Health […]

The endoscopic modified Lothrop procedure: finally ready for prime time in the management of inflammatory sinus disease.

The endoscopic modified Lothrop procedure: finally ready for prime time in the management of inflammatory sinus disease. Int Forum Allergy Rhinol. 2016 Feb 3; Authors: Smith TL PMID: 26840660 [PubMed – as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1SuXSOb via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis […]

Congenital and developmental cataract: axial length and keratometry study in Brazilian children.

Congenital and developmental cataract: axial length and keratometry study in Brazilian children. Arq Bras Oftalmol. 2016 Feb;79(1):19-23 Authors: Prado RB, Silva VF, Schellini SA, Rodrigues AC Abstract PURPOSE: To evaluate the ocular axial length (AL) and keratometry (K) in Brazilian children with congenital/developmental cataract, assess the differences and evolution of AL and K according to […]

Analytical calculation of proton linear energy transfer in voxelized geometries including secondary protons.

Analytical calculation of proton linear energy transfer in voxelized geometries including secondary protons. Phys Med Biol. 2016 Feb 3;61(4):1705-1721 Authors: Sanchez-Parcerisa D, Cortés-Giraldo MA, Dolney D, Kondrla M, Fager M, Carabe A Abstract In order to integrate radiobiological modelling with clinical treatment planning for proton radiotherapy, we extended our in-house treatment planning system FoCa with […]

Marital status independently predicts gastric cancer survival after surgical resection– an analysis of the SEER database.

Marital status independently predicts gastric cancer survival after surgical resection– an analysis of the SEER database. Oncotarget. 2016 Jan 31; Authors: Shi RL, Chen Q, Yang Z, Pan G, Zhang Z, Wang W, Liu S, Zhang D, Jiang D, Liu W Abstract Marital status was found to be an independent prognostic factor for survival in […]

Evaluation of virulence factors of Candida albicans isolated from HIV-positive individuals using HAART

Publication date: Available online 4 February 2016 Source:Archives of Oral Biology Author(s): Ralciane Menezes, Érika Riceto, Aércio Borges, Denise Röder, Reginaldo Pedroso The colonization by Candida species is one of the most important factors related to the development of oral candidiasis in HIV-infected individuals. The aim of the study was to evaluate and discuss the […]

Human Neutrophil Peptide-1 Affects Matrix Metalloproteinase-2, -8 and -9 Secretions of Oral Squamous Cell Carcinoma Cell Lines in vitro

Publication date: Available online 4 February 2016 Source:Archives of Oral Biology Author(s): Ahmed Ali Musrati, Taina Tervahartiala, Mervi Gürsoy, Eija Könönen, Dareen Fteita, Timo Sorsa, Veli-Jukka Uitto, Ulvi Kahraman Gürsoy ObjectivesThe present study aimed to investigate the effect of HNP-1 on the matrix metalloproteinase (MMP)-2, -8 and -9 secretions of two oral squamous cell carcinoma […]

The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model

Publication date: Available online 3 February 2016 Source:Archives of Oral Biology Author(s): Suzuro Hitomi, Ono Kentaro, Kiichiro Yamaguchi, Kiyoshi Terawaki, Ryota Imai, Kunitsugu Kubota, Yuji Omiya, Tomohisa Hattori, Yoshio Kase, Kiyotoshi Inenaga ObjectiveRecent studies have demonstrated that mouthwash made with the traditional Japanese medicine hangeshashinto exhibits anti-inflammatory action and alleviates oral mucositis scores, including pain […]

DEFB1 polymorphisms and susceptibility to recurrent tonsillitis in Italian children

Publication date: April 2016 Source:International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Luisa Zupin, Vania Polesello, Domenico Leonardo Grasso, Sergio Crovella, Ludovica Segat IntroductionThe tonsils are secondary lymphoid organs fundamental for immune system response against pathogens within the oral cavity. Tonsillitis refers to inflammation of the pharyngeal tonsils that may include the adenoids and the […]

Bedside tests to predict laryngoscopic difficulty in pediatric patients

Publication date: Available online 3 February 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): André Marques Mansano, Norma Sueli Pinheiro Módolo, Leopoldo Muniz da Silva, Eliana Maria Ganem, Leandro Gobbo Braz, Andrea de Carvalho Knabe, Fernanda Moreira de Freitas BACKGROUND AND OBJECTIVESPediatric airway management is a priority during anesthesia, critical care and emergency medicine. The purpose […]

Assessment of nasal mucociliary activity in patients with Behçet’s disease

Research Articles I Ozbay, C Kucur, F Temİzturk, Y Ozkan, C Kahraman, F Oghan The Journal of Laryngology & Otology,FirstView Article(s), 4 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PC6z6H via IFTTT

Abstracts presented at the South West ENT Academic Meeting 2015, Bath, UK

Abstracts The Journal of Laryngology & Otology,FirstView Article(s), 6 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mfB7Pz via IFTTT

【Events】»ECR 2016″ added to Events.

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1S2edJB via IFTTT

Speech recognition in noise under hearing protection: A computational study of the combined effects of hearing loss and hearing protector attenuation.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 1 ώρα
*Speech recognition in noise under hearing protection: A computational study of the combined effects of hearing loss and hearing protector attenuation.* Int J Audiol. 2016 Feb;55(sup1):S30-S40 Authors: Giguère C, Berger EH Abstract OBJECTIVE: To investigate the effects of hearing protection on speech recognition in noise. DESIGN: Computational study using a speech recognition model that was previously empirically validated. STUDY SAMPLE: Recognition scores were calculated in unprotected and protected conditions for four sets of hearing protector attenuation functions in two diffe...περισσότερα »

Celebrating hearing loss prevention.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 1 ώρα
*Celebrating hearing loss prevention.* Int J Audiol. 2016 Feb;55(sup1):S1-S2 Authors: Le Prell CG, Grantham MA PMID: 26840921 [PubMed - as supplied by publisher] from #Audiology via ola Kala on Inoreader http://ift.tt/1NRMQKD via IFTTT

From Dancing to Debilitated

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
[image: nejmcps1311794.fp.png_v03] Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors' commentary follows. Stage. A 69-year-old man sought care… from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1X57i1F via IFTTT

Tolerable Risks? Physicians and Youth Tackle Football

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
At least 11 U.S. high-school athletes died playing football during the fall 2015 season. Their deaths attracted widespread media attention and provided fodder for ongoing debates over the safety of youth tackle football. In October 2015, the American Academy of Pediatrics (AAP) issued its first… from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1QenGaT via IFTTT

Climatic Factors and Epidemiologic Characteristics of Head and Neck Skin Malignancies in Osijek Baranja County, Croatia.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Climatic Factors and Epidemiologic Characteristics of Head and Neck Skin Malignancies in Osijek Baranja County, Croatia.* Cent Eur J Public Health. 2015 Dec;23(4):275-285 Authors: Orkić Ž, Puntarić D, Vidosavljević D, Puntarić I, Puntarić E, Gvozdić V, Mayer D, Vidosavljević M, Vranješ AM Abstract AIM: The aim of this study was to investigate and compare the incidence and epidemiological characteristics of head and/or neck skin malignancies in Osijek-Baranja County, Croatia, and to connect them with relative climatic indicators such as the number and intensity of sunny and cloudy...περισσότερα »

A Multidisciplinary Approach to Castleman Disease of the Neck.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*A Multidisciplinary Approach to Castleman Disease of the Neck.* South Med J. 2016 Feb;109(2):78-82 Authors: Shams AA, Ahmed MM, Scalzitti NJ, Howell DL, Hall JM, Ritter JL, Maturo SC Abstract Castleman disease (CD) is a rare lymphoproliferative disorder that occurs in adults and rarely in the pediatric population. The disease is characterized by slowly enlarging masses that can form anywhere within the lymphatic system. It is an uncommon cause of a neck mass in both children and adults that presents insidiously and nonspecifically. A 21-year-old woman was referred to the otolary...περισσότερα »

Multidisciplinary Clinical Case Study.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Multidisciplinary Clinical Case Study.* South Med J. 2016 Feb;109(2):77 Authors: Holt GR PMID: 26840959 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1NRMKCR via IFTTT

Analytical calculation of proton linear energy transfer in voxelized geometries including secondary protons.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Analytical calculation of proton linear energy transfer in voxelized geometries including secondary protons.* Phys Med Biol. 2016 Feb 3;61(4):1705-1721 Authors: Sanchez-Parcerisa D, Cortés-Giraldo MA, Dolney D, Kondrla M, Fager M, Carabe A Abstract In order to integrate radiobiological modelling with clinical treatment planning for proton radiotherapy, we extended our in-house treatment planning system FoCa with a 3D analytical algorithm to calculate linear energy transfer (LET) in voxelized patient geometries. Both active scanning and passive scattering delivery modalities are ... περισσότερα »

The endoscopic modified Lothrop procedure: finally ready for prime time in the management of inflammatory sinus disease.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*The endoscopic modified Lothrop procedure: finally ready for prime time in the management of inflammatory sinus disease.* Int Forum Allergy Rhinol. 2016 Feb 3; Authors: Smith TL PMID: 26840660 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1SuXSOb via IFTTT

Congenital and developmental cataract: axial length and keratometry study in Brazilian children.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Congenital and developmental cataract: axial length and keratometry study in Brazilian children.* Arq Bras Oftalmol. 2016 Feb;79(1):19-23 Authors: Prado RB, Silva VF, Schellini SA, Rodrigues AC Abstract PURPOSE: To evaluate the ocular axial length (AL) and keratometry (K) in Brazilian children with congenital/developmental cataract, assess the differences and evolution of AL and K according to age, and establish functional models of AL and K as function of age. METHODS: Children with congenital/developmental cataract aged 1.5 months old to 8 years old and no other ocular diseases...περισσότερα »

Marital status independently predicts gastric cancer survival after surgical resection-- an analysis of the SEER database.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Marital status independently predicts gastric cancer survival after surgical resection-- an analysis of the SEER database.* Oncotarget. 2016 Jan 31; Authors: Shi RL, Chen Q, Yang Z, Pan G, Zhang Z, Wang W, Liu S, Zhang D, Jiang D, Liu W Abstract Marital status was found to be an independent prognostic factor for survival in various cancer types, but it hasn't been studied in gastric cancer. The Surveillance, Epidemiology and End Results database was used to compare survival outcomes with marital status. A total of 16,106 eligible patients were identified. Patients in the widowed... περισσότερα »

Standardized letters of recommendation and successful match into otolaryngology.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Standardized letters of recommendation and successful match into otolaryngology.* Laryngoscope. 2016 Feb 3; Authors: Kimple AJ, McClurg SW, Del Signore AG, Tomoum MO, Lin FC, Senior BA Abstract OBJECTIVES/HYPOTHESIS: Historically, narrative letters of recommendation have been utilized in the selection of applicants for otolaryngology residency programs. In the last two application cycles, our specialty adopted a standardized letter of recommendation (SLOR). The intent was to decrease time burden for letter writers and to provide readers with an objective evaluation of applicants...περισσότερα »

Targeting head and neck tumoral stem cells: From biological aspects to therapeutic perspectives.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Targeting head and neck tumoral stem cells: From biological aspects to therapeutic perspectives.* World J Stem Cells. 2016 Jan 26;8(1):13-21 Authors: Méry B, Guy JB, Espenel S, Wozny AS, Simonet S, Vallard A, Alphonse G, Ardail D, Rodriguez-Lafrasse C, Magné N Abstract Head and neck squamous cell cancer (HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of the disease. In most cases, treatment fails to obtain total cancer cure. In recent years, it appe...περισσότερα »

Aspiration as a late complication after accelerated versus conventional radiotherapy in patients with head and neck cancer.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Aspiration as a late complication after accelerated versus conventional radiotherapy in patients with head and neck cancer.* Acta Otolaryngol. 2016 Mar;136(3):304-11 Authors: Lindblom U, Nilsson P, Gärskog O, Kjellen E, Laurell G, Wahlberg P, Zackrisson B, Levring Jäghagen E Abstract Conclusion Neck dissection after radiotherapy increased the risk of aspiration as a late effect in a sub-sample of patients treated for head and neck cancer in the ARTSCAN study. Patients treated with accelerated fractionation (AF) developed aspiration, with or without coughing, more frequently than...περισσότερα »

Thyroid Cancer Epidemiology in Iran: a Time Trend Study.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Thyroid Cancer Epidemiology in Iran: a Time Trend Study.* Asian Pac J Cancer Prev. 2016;17(1):407-12 Authors: Safavi A, Azizi F, Jafari R, Chaibakhsh S, Safavi AA Abstract BACKGROUND: Considering the rising incidence of thyroid cancer worldwide, the aim of our study was to investigate the temporal trends in the incidence of this cancer in a large population of Iranian patients. MATERIALS AND METHODS: We used the Iran Cancer Data System (ICDS) Registry to assess the thyroid cancer trend from 2004 to 2010 with regard to different genders, age groups, and morphologies. To do this we ...περισσότερα »

A prospective study to assess the efficacy and toxicity of 5-flurouracil and cisplatin versus taxane and cisplatin as induction chemotherapy in locally advanced head and neck squamous cell cancer in a regional cancer center in India.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*A prospective study to assess the efficacy and toxicity of 5-flurouracil and cisplatin versus taxane and cisplatin as induction chemotherapy in locally advanced head and neck squamous cell cancer in a regional cancer center in India.* Indian J Cancer. 2015 Jan-Mar;52(1):65-8 Authors: Lakshmaiah KC, Rudresha AH, Suresh TM, Lokanatha D, Babu GK, Jacob LA Abstract AIM: The aim of this study is to assess the efficacy and toxicity of 5-flurouracil (5-FU) and cisplatin (PF) versus taxane and cisplatin (TP) as induction chemotherapy in locally advanced head and neck squamous cell canc...περισσότερα »

Synchronous primary cancers in the head and neck region and upper aero digestive tract: Role of triple endoscopy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Synchronous primary cancers in the head and neck region and upper aero digestive tract: Role of triple endoscopy.* Indian J Cancer. 2015 Jan-Mar;52(1):53-6 Authors: Krishnatreya M, Rahman T, Kataki AC, Lahkar K Abstract BACKGROUND: Patients with cancers in the head and region are at increased risk of developing synchronous primary cancers. AIM: The aim of this study is to see the role of endoscopy in the pre-therapeutic works-up of patients with the cancers in the head and neck region. MATERIALS AND METHODS: Data of head and neck cancer patients from January 2010 to December 2011...περισσότερα »

Factors Impacting Advance Care Planning among African Americans: Results of a Systematic Integrated Review.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Factors Impacting Advance Care Planning among African Americans: Results of a Systematic Integrated Review.* J Palliat Med. 2016 Feb;19(2):202-227 Authors: Sanders JJ, Robinson MT, Block SD Abstract BACKGROUND: African Americans (AA) are more likely to receive worse end-of-life (EOL) care and are less likely to participate in advance care planning (ACP) than white Americans. OBJECTIVE: Our goal was to understand factors impacting ACP among AA and explore their interactions, in order to guide further research and intervention development. METHODS: We systematically identified, usi...περισσότερα »

Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway.

Alexandros G. SfakianakisστοHead and NeckΠριν από 2 ώρες
*Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway.* Oncotarget. 2016 Jan 28; Authors: Deng J, Lei W, Xiang X, Zhang L, Lei J, Gong Y, Song M, Wang Y, Fang Z, Yu F, Feng M, Sun Z, Chen J, Zhan Z, Xiong J Abstract Although Cullin 4A (CUL4A) is mutated or amplified in several human cancer types, its role in gastric cancer (GC) and the mechanisms underlying its regulation remain largely uncharacterized. In the present study, we report that the expression of CUL4A significantly correla...περισσότερα »