Brachytherapy vs. external beam radiotherapy for choroidal melanoma
: Survival and patterns-of-care analyses via Brachytherapy Publication date: Available online 1 February 2016 *Source:*Brachytherapy Author(s): Matthew J. Abrams, Nolan L. Gagne, Christopher S. Melhus, John E. Mignano PurposeNo modern randomized trials exist comparing external beam radiotherapy (EBRT) and plaque brachytherapy (BT) for choroidal melanoma, and the optimal treatment modality is currently unknown. This study compares the patterns of care and efficacy of EBRT vs. BT based on data in the Surveillance, Epidemiology, and End Results database.Methods and MaterialsThe Surveilla... περισσότερα »
BRAF and Epithelial-Mesenchymal Transition in Primary Cutaneous Melanoma: A Role for Snail and E-Cadherin?
BRAF and Epithelial-Mesenchymal Transition in Primary Cutaneous Melanoma: A Role for Snail and E-Cadherin?: In vitro studies in melanoma indicate that upregulation of the transcriptional repressor Snail occurs with a concomitant decrease of its target E-cadherin, both hallmarks of epithelial-mesenchymal transition (EMT) – an association not established in vivo. We sought to elucidate the relationship between BRAF, Snail, E-cadherin and established histopathologic prognosticators in primary cutaneous melanoma (PCM). Archived annotated samples with a diagnosis of PCM were retrieved (n...περισσότερα »
Awareness of sunburn in childhood, use of sunbeds and change of moles
Awareness of sunburn in childhood, use of sunbeds and change of moles in Denmark, Northern Ireland, Norway and Sweden: *Background:* Malignant melanoma (MM) is increasing rapidly in Northern Europe. To reduce incidence and mortality through earlier diagnosis, public awareness of MM is important. Thus, we aim to examine awareness of risk factors and a symptom of MM, and how awareness varies by country and socio-demographic factors in Denmark, Northern Ireland (NI), Norway and Sweden. *Methods:* Population-based telephone interviews using the ‘Awareness and Beliefs about Cancer’ meas... περισσότερα »
Cytotoxic Activity Against Human Neuroblastoma and Melanoma Cells Mediated by IgM Antibodies Derived from Peripheral Blood of Healthy Donors
Cytotoxic Activity Against Human Neuroblastoma and Melanoma Cells Mediated by IgM Antibodies Derived from Peripheral Blood of Healthy Donors: Abstract A small percentage of healthy donors identified in the Western population carry antibodies in their peripheral blood which convey cytotoxic activity against certain human melanoma and neuroblastoma cell lines. We measured the cytotoxic activity of sera and plasmas from healthy donors on the human neuroblastoma cell line Kelly and various melanoma cell lines. Antibodies of IgM isotype, presumably belonging to the class of naturally occ...περισσότερα »
Conditional Melanoma Cancer Survival
Cancers, Vol. 8, Pages 20: Conditional Melanoma Cancer Survival in the United States: Beyond relative survival, which indicates the likelihood that patients will not die from causes associated with their cancer, conditional relative survival probabilities provide further useful prognostic information to cancer patients, tailored to the time already survived from diagnosis. This study presents conditional relative survival for melanoma patients in the United States, diagnosed during 2000–2008 and followed through 2012. Analyses are based on 62,803 male and 50,261 female cases in popu...περισσότερα »
Primary melanoma of the leptomeninges with bap1 expression-loss in the setting of a nevus of ota: A clinical, morphological and genetic study of 2 cases
Primary melanoma of the leptomeninges with bap1 expression-loss in the setting of a nevus of ota: A clinical, morphological and genetic study of 2 cases:
Comparative immune phenotypic analysis of cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in immune-competent individuals: proportional representation of CD8+ T-cells but not FoxP3+ Regulatory T-cells is associated with disease stage.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
[image: http:--www.plosone.org-images-pone_120x3] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Freeman A, Bridge JA, Maruthayanar P, Overgaard NH, Jung JW, Simpson F, Prow TW, Soyer HP, Frazer IH, Freeman M, Wells JW Abstract Squamous Cell Carcinoma (SCC) is a type of non-melanoma skin cancer prevalent in immune-suppressed transplant recipients and older individuals with a history of chronic sun-exposure. SCC itself is believed to be a late-stage manifestation that can develop from premalignant lesions including Intraepidermal Carcinoma (IEC). Notably, while SCC regr... περισσότερα »
Pedunculated polypoid melanoma. A rare spindle-cell variant of melanoma.
Pedunculated polypoid melanoma. A case report of a rare spindle-cell variant of melanoma Authors: Agostini P, Rivero A, Parra Martin JA, Soares-de-Almeida L Abstract We report an 89-year-old man who presented with a slowly growing pigmented pedunculated tumor. The nodule was diagnosed as a spindle cell pedunculated malignant melanoma (PMM), a rare variant of spindle-cell malignant melanoma. The clinical presentation of this tumor and its histological and immunohistological features are discussed. PMID: 25933079 [PubMed - indexed for MEDLINE]
A misdiagnosed melanoma: a case of cutaneous epithelioid malignant peripheral nerve sheath tumor.
A misdiagnosed melanoma: a case of cutaneous epithelioid malignant peripheral nerve sheath tumor Dermatol Online J. Authors: Linos K, Warren S Abstract Malignant Peripheral Nerve Sheath Tumor (MPNST) is a rare soft tissue sarcoma that can occur in superficial locations. Histologically it is categorized into two variants: a conventional/spindled and an epithelioid variant. The latter one is very rare and can be confused histologically with malignant melanoma as it is diffusely positive for S100-protein. Herein we present a case that was initially misdiagnosed as malignant melanoma... περισσότερα »
Case report of nodular melanoma within congenital melanocytic nevus- primary closure challenge.
Case report of nodular melanoma within congenital melanocytic nevus- primary closure challenge.: *Case report of nodular melanoma within congenital melanocytic nevus- primary closure challenge.* Int J Surg Case Rep. 2016 Jan 22;20:84-86 Authors: Eljuga D, Milas I, Kirac I, Stanec M, Vrdoljak DV Abstract INTRODUCTION: Congenital melanocytic nevi (CMN) are present in 1-2% of newborn infants. The size of CMN defines the risk of developing melanoma which is estimated from 5-10%, especially in lesions that are located across the spine. PRESENTATION OF CASE: Herein we report a case wh...περισσότερα »
Pluripotency markers are differentially induced by MEK inhibition in thyroid and melanoma BRAFV600E cell lines.
Pluripotency markers are differentially induced by MEK inhibition in thyroid and melanoma BRAFV600E cell lines.: *Pluripotency markers are differentially induced by MEK inhibition in thyroid and melanoma BRAFV600E cell lines.* Cancer Biol Ther. 2016 Feb 1;:0 Authors: Dorris ER, Blackshields G, Sommerville G, Alhashemi M, Dias A, McEneaney V, Smyth P, O'Leary JJ, Sheils O Abstract Oncogenic mutations in BRAF are common in melanoma and thyroid carcinoma and drive constitutive activation of the MAPK pathway. Molecularly targeted therapies of this pathway improves survival compared t...περισσότερα »
Hidden acral lentiginous melanoma with cutaneous metastases masquerading as Kaposi's sarcoma in an HIV-positive Indian man
Hidden acral lentiginous melanoma with cutaneous metastases masquerading as Kaposi's sarcoma in an HIV-positive Indian man: A 33-year-old HIV-positive Indian man presented with multiple bluish and erythematous papulo-nodules on his right leg and foot. A diagnosis of Kaposi's sarcoma was suspected clinically. Biopsy of the cutaneous lesions showed features of melanoma. On careful re-examination, an irregular brown-black macule, of which the patient was unaware, was noted on the ipsilateral sole. Histological examination of the sole lesion also showed features of melanoma. Systemic e...περισσότερα »
Upper limb melanoma
Patient with giant upper limb melanoma presenting to a UK plastic surgery unit: differentials and experience of management: A 57-year-old woman was referred to our regional sarcoma unit following a 2-year history of a progressively enlarging mass on her right forearm. At 14x7x12 cm, this mass turned out to be one of the largest upper limb cutaneous malignant melanomas ever described, and, to the best of our knowledge, the first documented in the UK. Remarkably, despite having a T4 malignant tumour with a Breslow thickness of 70 mm, this patient is still alive over 4 years later wit... περισσότερα »
Wide versus narrow excision margins for high-risk, primary cutaneous melanomas: long-term follow-up of survival in a randomised trial
[Articles] Wide versus narrow excision margins for high-risk, primary cutaneous melanomas: long-term follow-up of survival in a randomised trial: Our findings suggest that a 1 cm excision margin is inadequate for cutaneous melanoma with Breslow thickness greater than 2 mm on the trunk and limbs. Current guidelines advise a 2 cm margin for melanomas greater than 2 mm in thickness but only a 1 cm margin for thinner melanomas. The adequacy of a 1 cm margin for thinner melanomas with poor prognostic features should be addressed in future randomised studies.
Excision margins for melanomas: how wide is enough?
[Comment] Excision margins for melanomas: how wide is enough?: [image: fx1.sml] The main aim of surgery in treating any cancer is to completely excise the tumour, thereby preventing local recurrence. In the case of melanoma, the purpose of a wide excision is to remove local micrometastases and otherwise phenotypically normal tissue that might be harbouring genotypically abnormal cells located in either the surrounding cutis or superficial lymphatics, while at the same time trying to prevent unacceptable functional and cosmetic harm to the patient as a result.
Immunotherapy Combined or Sequenced With Targeted Therapy in the Treatment of Solid Tumors: Current Perspectives
Immunotherapy Combined or Sequenced With Targeted Therapy in the Treatment of Solid Tumors: Current Perspectives: The advent of newer immunotherapeutic and molecularly targeted agents has provided a number of effective options for cancer treatment but has also added much complexity in selecting the best initial treatment or treatment plan for each patient. Molecularly targeted agents offer selectivity and are the cornerstone for "precision medicine." While targeted agents are associated with high tumor response rates, patients inevitably develop resistance to these drugs. Immunothe...περισσότερα »
Serum lactate dehydrogenase as an early marker for outcome in patients treated with anti-PD-1 therapy in metastatic melanoma
Serum lactate dehydrogenase as an early marker for outcome in patients treated with anti-PD-1 therapy in metastatic melanoma: *Serum lactate dehydrogenase as an early marker for outcome in patients treated with anti-PD-1 therapy in metastatic melanoma* British Journal of Cancer 114, 256 (02 February 2016). doi:10.1038/bjc.2015.467 Authors: S Diem, B Kasenda, L Spain, J Martin-Liberal, R Marconcini, M Gore & J Larkin
Excision margins for melanomas: how wide is enough?
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
[Comment] Excision margins for melanomas: how wide is enough?: [image: fx1.sml] The main aim of surgery in treating any cancer is to completely excise the tumour, thereby preventing local recurrence. In the case of melanoma, the purpose of a wide excision is to remove local micrometastases and otherwise phenotypically normal tissue that might be harbouring genotypically abnormal cells located in either the surrounding cutis or superficial lymphatics, while at the same time trying to prevent unacceptable functional and cosmetic harm to the patient as a result.
The Diagnostic Value of Skin Disease Diagnosis Expert System
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
The Diagnostic Value of Skin Disease Diagnosis Expert System: 2016-02-03T17-20-00Z *Source:* Acta Informatica Medica Fatemeh Rangraz Jeddi, Masoud Arabfard, Zahra Arbkermany, Hamidreza Gilasi. Background: Evaluation is a necessary measure to ensure the effectiveness and efficiency of all systems, including expert systems. The aim of this study was to determine the diagnostic value of expert system for diagnosis of complex skin diseases. Methods: A case-control study was conducted in 2015 to determine the diagnostic value of an expert system. The study population included patients ...περισσότερα »
Immunotherapy Combined or Sequenced With Targeted Therapy in the Treatment of Solid Tumors: Current Perspectives
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Immunotherapy Combined or Sequenced With Targeted Therapy in the Treatment of Solid Tumors: Current Perspectives: The advent of newer immunotherapeutic and molecularly targeted agents has provided a number of effective options for cancer treatment but has also added much complexity in selecting the best initial treatment or treatment plan for each patient. Molecularly targeted agents offer selectivity and are the cornerstone for "precision medicine." While targeted agents are associated with high tumor response rates, patients inevitably develop resistance to these drugs. Immunothe...περισσότερα »
Relation of statin use with non-melanoma skin cancer: prospective results from the Women’s Health Initiative
Relation of statin use with non-melanoma skin cancer: prospective results from the Women’s Health Initiative: *Relation of statin use with non-melanoma skin cancer: prospective results from the Women’s Health Initiative* British Journal of Cancer 114, 314 (02 February 2016). doi:10.1038/bjc.2015.376 Authors: Ange Wang, Marcia L Stefanick, Kristopher Kapphahn, Haley Hedlin, Manisha Desai, Jo Ann E Manson, Howard Strickler, Lisa Martin, Jean Wactawski-Wende, Michael Simon & Jean Y Tang
A phase II study of cediranib, an oral VEGF inhibitor, in previously untreated patients with metastatic or recurrent malignant melanoma
A phase II study of cediranib, an oral VEGF inhibitor, in previously untreated patients with metastatic or recurrent malignant melanoma: Summary*Purpose* A two stage multi-institution Phase II study was undertaken by the Princess Margaret Hospital Consortium to evaluate the efficacy and toxicity of oral cediranib, an inhibitor of vascular endothelial growth factor receptors 1 and 2, in patients with previously untreated advanced malignant melanoma. *Patients and Methods* Between May 2006 and April 2008, 24 patients (median age 65 years) with advanced malignant melanoma were treated...περισσότερα »
Autologous melanoma cell vaccine using monocyte-derived dendritic cells (NBS20/eltrapuldencel-T)
Autologous melanoma cell vaccine using monocyte-derived dendritic cells (NBS20/eltrapuldencel-T): Future Oncology Ahead of Print.
Melanoma: PDX System for Modeling Personalized Medicine
Of Mice and Melanoma: PDX System for Modeling Personalized Medicine: Targeted therapies have advanced the treatment options for cutaneous melanoma but many patients will progress on drug. Patient-derived xenografts (PDX) can be used to recapitulate therapy resistant tumors. Furthermore, PDX modeling can be utilized in combination with targeted sequencing and phospho-proteomic platforms providing pre-clinical basis for second-line targeted inhibitor strategies.
Endocrine Reviews Vol. 37, No. 1, February 1, 2016 is now available online
Table of Contents Alert Endocrine Reviews-*Volume*: 37, *Number*: 1 (February 2016) ------------------------------ The above issue is now available online at: http://press.endocrine.org/toc/edrv/37/1?ai=s0&ui=26u7&af=H ------------------------------ [image: Endocrine Reviews masthead] ------------------------------ ------------------------------ Endocrine Reviews Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Editorial From the Editor-in-Chief of Endocrine Reviews on the ... περισσότερα »
Advanced Monitoring Is Associated with Fewer Alarm Events During Planned Moderate Procedure-Related Sedation: A 2-Part Pilot Trial.
Advanced Monitoring Is Associated with Fewer Alarm Events During Planned Moderate Procedure-Related Sedation: A 2-Part Pilot Trial.: BACKGROUND: Diagnostic and interventional procedures are often facilitated by moderate procedure-related sedation. Many studies support the overall safety of this sedation; however, adverse cardiovascular and respiratory events are reported in up to 70% of these procedures, more frequently in very young, very old, or sicker patients. Monitoring with pulse oximetry may underreport hypoventilation during sedation, particularly if supplemental oxygen is p... περισσότερα »
An unusual cause of postoperative airway obstruction: Perioral Piercings
An unusual cause of postoperative airway obstruction: A case report:
IJMS, Vol. 17, Pages 190: GLP-2 Attenuates LPS-Induced Inflammation in BV-2 Cells by Inhibiting ERK1/2, JNK1/2 and NF-κB Signaling Pathways
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
The pathogenesis of Parkinson's disease (PD) often involves the over-activation of microglia. Over-activated microglia could produce several inflammatory mediators, which trigger excessive inflammation and ultimately cause dopaminergic neuron damage. Anti-inflammatory effects of glucagon-like peptide-2 (GLP-2) in the periphery have been shown. Nonetheless, it has not been illustrated in the brain. Thus, in this study, we aimed to understand the role of GLP-2 in microglia activation and to elucidate the underlying mechanisms. BV-2 cells were pretreated with GLP-2 and then stimulate... περισσότερα »
IJMS, Vol. 17, Pages 206: Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Polymorphisms in certain inflammatory-related genes have been identified as putative differential risk factors of neurodegenerative diseases with abnormal protein aggregates, such as sporadic Alzheimer's disease (AD) and sporadic Parkinson's disease (sPD). Gene expression studies of cytokines and mediators of the immune response have been made in post-mortem human brain samples in AD, sPD, sporadic Creutzfeldt-Jakob disease (sCJD) subtypes MM1 and VV2, Pick's disease (PiD), progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration linked to mutation P301L in MAPT ... περισσότερα »
IJMS, Vol. 17, Pages 201: Drug-Induced Liver Injury Network Causality Assessment: Criteria and Experience in the United States
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Hepatotoxicity due to drugs, herbal or dietary supplements remains largely a clinical diagnosis based on meticulous history taking and exclusion of other causes of liver injury. In 2004, the U.S. Drug-Induced Liver Injury Network (DILIN) was created under the auspices of the U.S. National Institute of Diabetes and Digestive and Kidney Diseases with the aims of establishing a large registry of cases for clinical, epidemiological and mechanistic study. From inception, the DILIN has used an expert opinion process that incorporates consensus amongst three different DILIN hepatologists... περισσότερα »
IJMS, Vol. 17, Pages 203: Use of Repetitive Sequences for Molecular and Cytogenetic Characterization of Avena Species from Portugal
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Genomic diversity of Portuguese accessions of Avena species—diploid A. strigosa and hexaploids A. sativa and A. sterilis—was evaluated through molecular and cytological analysis of 45S rDNA, and other repetitive sequences previously studied in cereal species—rye subtelomeric sequence (pSc200) and cereal centromeric sequence (CCS1). Additionally, retrotransposons and microsatellites targeting methodologies—IRAP (inter-retrotransposon amplified polymorphism) and REMAP (retrotransposon-microsatellite amplified polymorphism)—were performed. A very high homology was detected for riboso... περισσότερα »
Increased expression of senescence markers p14ARFand p16 INK4a in breast cancer is associated with increased risk of disease recurrence and poor survival outcome
Abstract Aims Breast cancer is a hormonally driven disease. Cellular senescence is an age-related irreversible cell cycle arrest at the G1 phase upon induction. This study aimed to characterize the expression patterns of senescence markers p14ARF, p16INK4a and p21*WAF**1/Cip1* during breast cancer progression in a large patient cohort. Methods and results We conducted a retrospective study of 1080 patients with invasive ductal carcinoma, no special type, over an 11 year period. We performed immunohistochemical staining on tissue microarrays that include normal, benign hyperplasi...περισσότερα »
Is Hormone Replacement Therapy Safe in Women With a BRCA Mutation?: A Systematic Review of the Contemporary Literature.
Objectives: Women with a BRCA1 or BRCA2 mutation are recommended to undergo prophylactic (or risk reducing) bilateral salpingo-oophorectomy (BSO) before age 40, resulting in surgical menopause. Given the concerns of estrogen deprivation on overall health, hormone therapy (HT) is often discussed, yet safety concerns persist. Materials and Methods: We performed a systematic literature review of the safety of HT in women with a BRCA mutation undergoing prophylactic BSO. Results: Although there remains a paucity of data on this topic, as evidenced by this systematic review of the contem...περισσότερα »
The Cancer Experience: The Doctor, The Patient, The Journey. Roy B. Sessions. Rowman & Littlefield Publishers, Inc., Lanham, Maryland, 2012. No. of pages: 205. Price: $59.95 (US) ISBN: 978-1442216211.
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Correlates of quality of life in overweight or obese breast cancer survivors at enrollment into a weight loss trial
Abstract Objective The purpose of this analysis was to examine the correlates of the physical and psychosocial domains of quality of life (QOL) in a cohort of breast cancer survivors participating in a weight loss intervention trial. Methods Correlates of QOL and psychosocial functioning were examined in 692 overweight or obese breast cancer survivors at entry into a weight loss trial. QOL was explored with three measures: Short-form 36 (SF-36), Impact of Cancer scale (IOC), and the Breast Cancer Prevention Trial (BCPT) symptom scales. Available data included information on weigh... περισσότερα »
Assessing the utility of a telephonically delivered psychoeducational intervention to improve health-related quality of life in African American breast cancer survivors: a pilot trial
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Journal Club.
No abstract available from Anaesthesia via ola Kala on Inoreader http://ift.tt/1NRvNs8 via IFTTT
Perioperative Management of Children With Giant Encephalocele: A Clinical Report of 29 Cases.
Background: Giant encephalocele, a rare entity, makes anesthesiologists wary of challenging anesthetic course. Apart from inherent challenges of pediatric anesthesia, the anesthesiologist has to deal with unusual positioning, difficult tracheal intubation, and associated anomalies during the perioperative course. Materials and Methods: Medical records of 29 children with giant encephalocele, who underwent excision and repair, during a period of 13 years, were retrospectively analyzed. Data pertaining to anesthetic management, perioperative complications, and outcome at discharge wer... περισσότερα »
Perioperative Evaluation and Care of Patients With Mild to Moderate Cerebrovascular Disease: It's Time to Develop Treatment Guidelines!
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Can Intraoperative Neurological Preconditioning Occur After Intraoperative Hypotensive Episodes?.
No abstract available from Anaesthesia via ola Kala on Inoreader http://ift.tt/1KrzZE0 via IFTTT
Comparison of recovery parameters for xenon versus other inhalation anesthetics: systematic review and meta-analysis
[image: gr1.sml] To summarize and evaluate the available data describing the recovery parameters of xenon anesthesia. from Anaesthesia via ola Kala on Inoreader http://ift.tt/1PBr8jH via IFTTT
Migration of skilled anaesthesiologists from low to high-income economies: Urgent action needed
No abstract available from Anaesthesia via ola Kala on Inoreader http://ift.tt/1nFS32S via IFTTT
Increased expression of senescence markers p14ARFand p16 INK4a in breast cancer is associated with increased risk of disease recurrence and poor survival outcome
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Abstract Aims Breast cancer is a hormonally driven disease. Cellular senescence is an age-related irreversible cell cycle arrest at the G1 phase upon induction. This study aimed to characterize the expression patterns of senescence markers p14ARF, p16INK4a and p21*WAF**1/Cip1* during breast cancer progression in a large patient cohort. Methods and results We conducted a retrospective study of 1080 patients with invasive ductal carcinoma, no special type, over an 11 year period. We performed immunohistochemical staining on tissue microarrays that include normal, benign hyperplasi...περισσότερα »
Divided attention in airway management
The effect of a standardised source of divided attention in airway management: A randomised, crossover, interventional manikin study: [image: image]BACKGROUND: Dual-tasking, the need to divide attention between concurrent tasks, causes a severe increase in workload in emergency situations and yet there is no standardised training simulation scenario for this key difficulty. OBJECTIVES: We introduced and validated a quantifiable source of divided attention and investigated its effects on performance and workload in airway management. DESIGN: A randomised, crossover, interventional sim...περισσότερα »
Tizanidine for the management of acute postoperative pain
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial: Abstract BACKGROUND: α2-Agonists are used postoperatively as a component of multimodal analgesia. Tizanidine is a centrally acting α2-agonist with muscle relaxant properties. OBJECTIVE: The aim of this study was to compare the efficacy of tizanidine with placebo in terms of postoperative pain scores, analgesic consumption, return to daily activity and health-related quality of life. DESIGN: A randomised double-blind study. SETTING: Diskapi Yildirim Beyazit... περισσότερα »
Modified GlideScope intubation technique on procedure times, airway morbidity and haemodynamic response
The effect of a modified GlideScope intubation technique on procedure times, airway morbidity and haemodynamic response:
Current issues in postoperative pain management
Current issues in postoperative pain management: [image: image] Postoperative pain has been poorly managed for decades. Recent surveys from USA and Europe do not show any major improvement. Persistent postoperative pain is common after most surgical procedures, and after thoracotomy and mastectomy, about 50% of patients may experience it. Opioids remain the mainstay of postoperative pain treatment in spite of strong evidence of their drawbacks. Multimodal analgesic techniques are widely used but new evidence is disappointing. Regional anaesthetic techniques are the most effective m... περισσότερα »
Epithelial discrimination of commensal and pathogenic Candida albicans
All mucosal surfaces are lined by epithelial cells and are colonised by opportunistic microbes. In health, these opportunistic microbes remain commensal and are tolerated by the immune system. However, when the correct environmental conditions arise, these microbes can become pathogenic and need to be controlled or cleared by the immune system to prevent disease. The… Continue reading Epithelial discrimination of commensal and pathogenic Candida albicans
Use of intravoxel incoherent motion MRI to assess renal fibrosis in a rat model of unilateral ureteral obstruction
Purpose To investigate the potential of intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) in assessment of renal fibrosis using a rat model of unilateral ureteral obstruction (UUO). Materials and Methods Thirty-two UUO rats were created by complete ligation of the left ureter. IVIM was performed on a clinical 3.0T whole-body MRI scanner before the… Continue reading Use of intravoxel incoherent motion MRI to assess renal fibrosis in a rat model of unilateral ureteral obstruction
Interactive role of miR-126 on VEGF-A and progression of papillary and undifferentiated thyroid carcinoma
Interactive role of miR-126 on VEGF-A and progression of papillary and undifferentiated thyroid carcinoma: MicroRNA-126 (miR-126) expression has been shown to be associated with angiogenesis. The aim of the current study is to evaluate the functional roles of miR-126 in dysregulation of VEGF expression and cancer progression in thyroid carcinomas. AbstractIntroduction MicroRNA-126 (*miR-126*) expression has been shown to be associated with angiogenesis. The aim of the current study is to evaluate the functional roles of *miR-126* in dysregulation of VEGF expression and cancer pro...περισσότερα »
Localization of specialized intestinal metaplasia and the molecular alterations in Barrett’s esophagus in a Japanese population: an analysis of biopsy samples based on the “Seattle” biopsy protocol
Localization of specialized intestinal metaplasia and the molecular alterations in Barrett’s esophagus in a Japanese population: an analysis of biopsy samples based on the “Seattle” biopsy protocol: It remains unclear why Barrett’s esophagus (BE)-associated adenocarcinoma (EAC) frequently occurs in the 0–3 o’clock area of the BE. The aims of this study were to clarify the localization of specialized intestinal metaplasia (SIM) as a precancerous lesion and of molecular alterations among different locations using four-quadrant biopsies based on the “Seattle” protocol. We prospectively...περισσότερα »
BRAF and Epithelial-Mesenchymal Transition in Primary Cutaneous Melanoma: A Role for Snail and E-Cadherin?
BRAF and Epithelial-Mesenchymal Transition in Primary Cutaneous Melanoma: A Role for Snail and E-Cadherin?: In vitro studies in melanoma indicate that upregulation of the transcriptional repressor Snail occurs with a concomitant decrease of its target E-cadherin, both hallmarks of epithelial-mesenchymal transition (EMT) – an association not established in vivo. We sought to elucidate the relationship between BRAF, Snail, E-cadherin and established histopathologic prognosticators in primary cutaneous melanoma (PCM). Archived annotated samples with a diagnosis of PCM were retrieved (n...περισσότερα »
Mutations in Langerhans cell histiocytosis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
and mutations in Langerhans cell histiocytosis: a study of 50 cases: Langerhans cell histiocytosis (LCH) is a proliferation of Langerhans cells, often associated with lymphocytes, eosinophils, macrophages, and giant cells. BRAF mutations, usually V600E, have been reported in 40-70% of cases, and recently MAP2K1 mutations have been reported in BRAF-negative cases. We assessed 50 cases of LCH for BRAF mutations and assessed a subset of cases for MAP2K1 mutations. The study group included 28 men and 22 women (median age, 36.5 years; range, 1–78 years). BRAF V600E mutation was detected ... περισσότερα »
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online ------------------------------ Early Release The Journal of Clinical Endocrinology & Metabolism ------------------------------ [image: Journal of Clinical Endocrinology & Metabolism masthead] ------------------------------ ------------------------------ The Journal of Clinical Endocrinology & Metabolism Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ miR-133b reverses the hydrosa... περισσότερα »
HLA-E*0103 alleles predictive markers for nasopharyngeal cancer risk
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
Are HLA-E*0103 alleles predictive markers for nasopharyngeal cancer risk? via ScienceDirect Publication: Pathology - Research and Practice Publication date: Available online 2 February 2016 *Source:*Pathology - Research and Practice Author(s): Hayet Douik, Neila Attia Romdhane, Fethi Guemira BackgroundNasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer, tightly related to Epstein Barr virus infection and thus to HLA genes. In this study, we aimed to analyze HLA-E polymorphism in NPC advent and prognosis.130 unrelated patients with CNP and 180 unrelated and healthy ... περισσότερα »
HLA-E polymorphism is associated with nasopharyngeal cancer. HLA-E expression studies could be used to understand the implication of E*103 variants.
Are HLA-E*0103 alleles predictive markers for nasopharyngeal cancer risk? via ScienceDirect Publication: Pathology - Research and Practice Publication date: Available online 2 February 2016 *Source:*Pathology - Research and Practice Author(s): Hayet Douik, Neila Attia Romdhane, Fethi Guemira BackgroundNasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer, tightly related to Epstein Barr virus infection and thus to HLA genes. In this study, we aimed to analyze HLA-E polymorphism in NPC advent and prognosis.130 unrelated patients with CNP and 180 unrelated and healthy ... περισσότερα »
Semi-nested PCR for the diagnosis of mucormycosis and aspergillosis
Diagnostic value of a semi-nested PCR for the diagnosis of mucormycosis and aspergillosis from paraffin-embedded tissue; a single center experience via ScienceDirect Publication: Pathology - Research and Practice Publication date: Available online 2 February 2016 *Source:*Pathology - Research and Practice Author(s): Maria Drogari-Apiranthitou, Ioannis Panayiotides, Irene Galani, Stefanos Konstantoudakis, Georgios Arvanitidis, Aris Spathis, Alina-Roxani Gouloumi, Zoi Tsakiraki, Sotirios Tsiodras, George Petrikkos ObjectiveThe main aim of our study was to investigate the diagnostic value ...περισσότερα »
Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: A cytological dilemma
Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: A cytological dilemma: *Chayanika Pantola, Sanjay Kala, Mohd. Athar, Sudeep Thakur* Journal of Cytology 2016 33(1):37-39 Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) of the thyroid is a rare primary thyroid tumor arising in a background of Hashimoto's/lymphocytic thyroiditis and has been recently introduced in the World Health Organization (WHO) classification of thyroid tumors. It is characterized by extensive sclerosis, squamous and glandular differentiation, and inflammatory infiltrate ric... περισσότερα »
Primary small cell carcinoma of the parotid: Fine needle aspiration and immunohistochemical features of a neuroendocrine variant
Primary small cell carcinoma of the parotid: Fine needle aspiration and immunohistochemical features of a neuroendocrine variant: *Serdar Altinay, Pinar Firat, Şenay Yalçin, ?mit Taşkin* Journal of Cytology 2016 33(1):34-36 Salivary gland small cell carcinoma (SGSmCC) is extremely rare, accounting for less than 1% of salivary gland tumors. A 42-year-old female patient came to the outpatient clinic due to a mass localized in the left submandibular space and that had been growing since 3-4 months. The fine needle aspiration cytology (FNAC) matched with small cell carcinoma (SmCC).... περισσότερα »
Fine-needle aspiration cytology of cutaneous granular cell tumor
Fine-needle aspiration cytology of cutaneous granular cell tumor: Report of two cases with special emphasis on cytological differential diagnosis: *Ujjawal Khurana, Uma Handa, Harsh Mohan* Journal of Cytology 2016 33(1):30-33 Granular cell tumors (GCTs) are uncommon neoplasms with recently postulated origin from Schwann cell or neural crest. It can appear in different parts of the body and is most commonly found in the tongue. The cutaneous presentation is not that uncommon. Fine needle aspiration cytology (FNAC) has been suggested to be the diagnostic modality of choice. It wil... περισσότερα »
Spindle epithelial tumor with thymus-like differentiation (SETTLE)
Review of the touch preparation cytology of spindle epithelial tumor with thymus-like differentiation: *Kijong Yi, Abdul Rehman, Se Min Jang, Seung Sam Paik* Journal of Cytology 2016 33(1):27-29 We experienced a case of spindle epithelial tumor with thymus-like differentiation (SETTLE) with touch preparation cytology performed during the intraoperative frozen section diagnosis in a 22-year-old woman. The tumor was partially encapsulated by fibrous capsule. It was a highly cellular biphasic tumor characterized by fasciculated spindle cells with streaming pattern and tubulopapill... περισσότερα »
Utility of fine-needle aspiration cytology in the identification of parathyroid lesions
Utility of fine-needle aspiration cytology in the identification of parathyroid lesions: *Niraj Kumari, Deepti Mishra, Roma Pradhan, Amit Agarwal, Narendra Krishnani* Journal of Cytology 2016 33(1):17-21 Objectives: Fine-needle aspiration cytology (FNAC) is a first-line investigation in the evaluation of neck nodules. In an attempt to search for reliable cytomorphological criteria for parathyroid lesions, we systematically evaluated cytomorphology of FNAC of parathyroid lesions. Study Design: FNAC of 15 parathyroid and 15 hyperplastic thyroid nodules with histological confirmati...περισσότερα »
Fine needle aspiration cytology of dermatopathic lymphadenitis
Fine needle aspiration cytology of dermatopathic lymphadenitis in an asymptomatic female: A case report: *Banushree C Srinivasamurthy, Kaushik Saha, Swagatika Senapati, Arpita Saha* Journal of Cytology 2016 33(1):49-51 Dermatopathic lymphadenopathy usually presents as enlarged superficial lymph nodes, most often involving the axillary or inguinal regions. Most patients have a chronic dermatopathy that precedes the development of dermatopathic lymphadenopathy. This condition can be confused with lymphoma in adults. There are very few case reports on cytological features of this ...περισσότερα »
Congenital naso-orbital meningocele
Congenital naso-orbital meningocele in a lamb: a case report: AbstractThe subject of this report is a rare case of naso-orbital meningocele concurrent with right cerebral hemisphere hydranencephaly and agenesis of corpus callosum in a newborn lamb. Our necropsy findings revealed that the bulging sac containing CSF extends into the skull bony and dural defects, through which the cyst protrudes into the orbital and nasal cavities. Also, histological and immunohistochemical demonstrations of the cyst wall showed that the inner layer is composed of meningeal components. These findings ...περισσότερα »
A variant of the classical superficial brachioulnoradial artery: morphology and clinical significances
A variant of the classical superficial brachioulnoradial artery: morphology and clinical significances: AbstractWe report a superficial brachioulnoradial artery (SBURA) presenting as a variant of the normal, originating from the proximal third of the right brachial artery of a 75-year-old female cadaver which bifurcated yielding a brachiointerosseous artery laterally and a SBURA medially, and the latter bifurcating 5 cm proximal to the elbow yielding a brachioradial artery laterally and the superficial brachioulnar artery medially, resulting in the formation of three instead of two... περισσότερα »
An arterial island pattern of the axillary and brachial arteries: a case report with clinical implications
An arterial island pattern of the axillary and brachial arteries: a case report with clinical implications: AbstractThe variability of axillary and brachial arteries is often associated with neural anomalies in arrangement of the brachial plexus. The current report is focused on the coexistence of two brachial arteries of axillary origin with an atypical median nerve formatted by three (two lateral and a medial) roots in the right arm of a 68-year-old male cadaver. Medially, the brachial artery located in front of the median nerve was named superficial brachial artery and anastomos... περισσότερα »
The relationship between tinnitus and vascular anomalies on temporal bone CT scan: a retrospective case control study
The relationship between tinnitus and vascular anomalies on temporal bone CT scan: a retrospective case control study: Abstract IntroductionTinnitus is a common symptom in which etiology is unclear in a group of patients. Some of anatomic or vascular variations diagnosed on temporal bone computed tomography (CT) has been known to cause tinnitus particulary pulsatile form. Therefore significance of these anatomic variations has not been validated in patients with nonpulsatile tinnitus. The aim of this study is to ascertain several anatomic variations previously attributed to pulsat... περισσότερα »
The posterior groove as a landmark for location of the palatovaginal canal in axial computed tomography
The posterior groove as a landmark for location of the palatovaginal canal in axial computed tomography: Abstract PurposeTo investigate use of posterior groove of palatovaginal (PV) canal as an anatomic landmark in determining the location of PV canal in axial computed tomography (CT) images of pterygopalatine fossa (PPF). MethodsA total of 20 skull specimens were examined in this analysis. Each skull was scanned by CT with and without a probe inserted through PV canal to measure the anatomic structures. CT images of 70 patients were used for comparing the rate of correct locat...περισσότερα »
Assessment of mandibular posterior regional landmarks
using cone-beam computed tomography in dental implant surgery via ScienceDirect Publication: Annals of Anatomy - Anatomischer Anzeiger Publication date: Available online 3 February 2016 *Source:*Annals of Anatomy - Anatomischer Anzeiger Author(s): Lílian Azevedo de Souza, Neuza Maria de Souza Picorelli Assis, Rosangela Almeida Ribeiro, Antônio Carlos Pires Carvalho, Karina Lopes Devito The aim of this study has been to evaluate and correlate the anatomical features of the posterior mandibular region (submandibular fossa depth, bone height and thickness, and mandibular canal corticaliza... περισσότερα »
Antisecretory medication is associated with decreased Helicobacter pylori detection
in gastric marginal zone lymphoma via Annals of Diagnostic Pathology *Source:*Annals of Diagnostic Pathology, Volume 19, Issue 6 Author(s): Kurt B. Schaberg, Mark F. Evans, Rebecca Wilcox, Michael R. Lewis Helicobacter pylori status influences the prognosis and management of gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), so accurate determination of H pylori status is of clinical importance. The low rate of histologic H pylori positivity among gastric MALT lymphoma cases at our institution prompted investigation for possible causes. A c...περισσότερα »
Ossifying fibromyxoid tumor (OFMT)
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis via Annals of Diagnostic Pathology Publication date: February 2016 *Source:*Annals of Diagnostic Pathology, Volume 20 Author(s): Nina Schneider, Cyril Fisher, Khin Thway Ossifying fibromyxoid tumor (OFMT) is a soft tissue neoplasm of uncertain differentiation and intermediate (rarely metastasizing) biologic potential, with typical morphologic features, of an encapsulated, lobulated tumor comprising uniform polygonal cells within fibromyxoid stroma, which is surrounded by or contains metaplastic bone, classica... περισσότερα »
Claudin-4 in spiradenomas
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Distinctive immunostaining of claudin-4 in spiradenomas via Annals of Diagnostic Pathology Publication date: February 2016 *Source:*Annals of Diagnostic Pathology, Volume 20 Author(s): Nuri Yiğit, Ertuğrul Çelik, İbrahim Yavan, Armağan Günal, Bülent Kurt, Yıldırım Karslıoğlu, Önder Öngürü, Ayhan Özcan The intercellular bridges are essential structures in maintaining the histologic organization of the epithelium, while providing a very efficient way to exchange molecules between cells and transduction of the cell-to-cell and matrix-to-cell signals. Derangement in those important structu... περισσότερα »
Myxoinflammatory fibroblastic sarcoma (MIFS),Pleomorphic hyalinizing angiectatic tumor (PHAT)
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
Pleomorphic hyalinizing angiectatic tumor revisited: all tumors manifest typical morphologic features of myxoinflammatory fibroblastic sarcoma, further suggesting 2 morphologic variants of a single entity via Annals of Diagnostic Pathology Publication date: February 2016 *Source:*Annals of Diagnostic Pathology, Volume 20 Author(s): Michael Michal, Dmitry V. Kazakov, Ladislav Hadravský, Abbas Agaimy, Marián Švajdler, Naoto Kuroda, Michal Michal We describe 9 cases of pleomorphic hyalinizing angiectatic tumor (PHAT). Recently described TGFBR3 and MGEA5 gene rearrangements in these tumors ... περισσότερα »
Schwannomas with pseudoglandular elements
Schwannomas with pseudoglandular elements: clinicopathologic study of 61 cases via Annals of Diagnostic Pathology Publication date: February 2016 *Source:*Annals of Diagnostic Pathology, Volume 20 Author(s): Nasir Ud Din, Zubair Ahmad, Arsalan Ahmed Schwannomas are benign neoplasms of peripheral nerve sheath. A number of morphologic variants of schwannoma have been described. The pseudoglandular variant is very rare. We retrieved and reviewed hematoxylin and eosin slides of all cases of schwannoma reported between 2007 and 2014 to look for pseudoglandular elements. Pseudoglandular cyst... περισσότερα »
Schwannomas with pseudoglandular elements
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
: clinicopathologic study of 61 cases via Annals of Diagnostic Pathology Publication date: February 2016 *Source:*Annals of Diagnostic Pathology, Volume 20 Author(s): Nasir Ud Din, Zubair Ahmad, Arsalan Ahmed Schwannomas are benign neoplasms of peripheral nerve sheath. A number of morphologic variants of schwannoma have been described. The pseudoglandular variant is very rare. We retrieved and reviewed hematoxylin and eosin slides of all cases of schwannoma reported between 2007 and 2014 to look for pseudoglandular elements. Pseudoglandular cystic spaces were seen in 61 (6.3%) of 971 s... περισσότερα »
Aberrant membranous expression of β-catenin predicts poor prognosis in patients with craniopharyngioma
Aberrant membranous expression of β-catenin predicts poor prognosis in patients with craniopharyngioma via Annals of Diagnostic Pathology Publication date: December 2015 *Source:*Annals of Diagnostic Pathology, Volume 19, Issue 6 Author(s): Zongping Li, Jianguo Xu, Siqing Huang, Chao You The objective of this study is to investigate β-catenin expression in craniopharyngioma patients and determine its significance in predicting the prognosis of this disease. Fifty craniopharyngioma patients were enrolled in this study. Expression of β-catenin in tumor specimens collected from these pati... περισσότερα »
Cytokeratin 17 immunoexpression in actinic keratosis
(bowenoid and nonbowenoid) and in Bowen disease via Annals of Diagnostic Pathology Publication date: February 2016 *Source:*Annals of Diagnostic Pathology, Volume 20 Author(s): Angel Fernandez-Flores Cytokeratin (CK) 17 immunoexpression has been investigated in nonmelanoma skin cancer as well as in many preinvasive epithelial malignancies. However, there is not any previous study of CK17 immunoexpression in actinic keratosis (AK) or Bowen disease in nonimmunocompromised patients. We evaluated CK17 immunoexpression in 20 cases of AK (10 nonbowenoid and 10 bowenoid) as well as in 10 cas... περισσότερα »
Reconstructive Microsurgery in Elderly Patients
Extending the Limits of via British Association of Plastic Surgeons Publication date: Available online 3 February 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): H.J. Klein, N. Fuchs, T. Mehra, R. Schweizer, T. Giesen, M. Calcagni, G.F. Huber, P. Giovanoli, J.A. Plock BackgroundPopulation ageing strongly affects the demographic development of industrialized countries. While microsurgical procedures were initially believed to be only feasible in patients of younger age because of the duration of the surgical procedure and the higher risk of vascular insu...περισσότερα »
Aberrant membranous expression of β-catenin predicts poor prognosis in patients with craniopharyngioma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Aberrant membranous expression of β-catenin predicts poor prognosis in patients with craniopharyngioma via Annals of Diagnostic Pathology Publication date: December 2015 *Source:*Annals of Diagnostic Pathology, Volume 19, Issue 6 Author(s): Zongping Li, Jianguo Xu, Siqing Huang, Chao You The objective of this study is to investigate β-catenin expression in craniopharyngioma patients and determine its significance in predicting the prognosis of this disease. Fifty craniopharyngioma patients were enrolled in this study. Expression of β-catenin in tumor specimens collected from these pati... περισσότερα »
Repairing the donor area of a distally based sural flap: Gastrocnemius perforator island flap
A convenient flap for via British Association of Plastic Surgeons Publication date: Available online 3 February 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Cengiz Eser, Eyüphan Gencel, Erol Kesiktaş, Ömer Kokaçya, Metin Yavuz ObjectsThe reconstruction of complex lower leg and foot defects is difficult for plastic surgeons. The distally based sural flap is an option for non-free flap lower leg reconstruction. However, one of the major drawbacks of the distally based sural flap is its aesthetically non-acceptable donor area scarring.Materials and meth... περισσότερα »
Microvascular free flaps
are a safe and suitable training procedure during structured plastic surgery residency: A comparative cohort study with 391 patients via British Association of Plastic Surgeons Publication date: Available online 3 February 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Christoph Hirche, Ulrich Kneser, Lingyun Xiong, Paul Wurzer, Felicitas Ringwald, Franziska Obitz, Sebastian Fischer, Leila Harhaus, Emre Gazyakan, Thomas Kremer BackgroundMicrovascular free flaps have become a reliable standard procedure. Due to increasing microsurgical experience in teac... περισσότερα »
The oral-systemic disease connection: a retrospective study
The oral-systemic disease connection: a retrospective study: Abstract ObjectivesThe study aimed at determining the association between oral disease and systemic health based on panoramic radiographs and general health of patients treated at Kuwait University Dental Center. The objective was to determine whether individuals exhibiting good oral health have lower propensity to systemic diseases. Materials and methodsA total of 1000 adult patients treated at Kuwait University Dental Center were randomly selected from the patient’s records. The general health of patients was assess...περισσότερα »
Oral leukoplakia treatment with the carbon dioxide laser: A systematic review of the literature
Oral leukoplakia treatment with the carbon dioxide laser: A systematic review of the literature: We conducted a systematic review of the literature to evaluate treatment of oral leukoplakia with the carbon dioxide (CO2) laser.A comprehensive search of studies published between 1981 and 2015 and listed in the PubMed (National Library of Medicine, NCBI) database yielded 378 articles which were screened in detail. Relevant studies were selected according to predetermined inclusion and exclusion criteria. A total of 33 articles met the final inclusion criteria and were analysed in detai... περισσότερα »
Function of the parotid gland in juvenile recurrent parotitis: a case series
Function of the parotid gland in juvenile recurrent parotitis: a case series Our aim was to find out how the parotid gland functions in 44 patients with juvenile recurrent parotitis, and to assess the value of measuring the serum amylase activity. Clinical and personal details were recorded, and all patients had their serum amylase activity measured together with sialography during the chronic phase. The function of the gland was classified by sialographic images. The chi square test and Spearman's rank correlation coefficient were used in the statistical analyses. There was a signi... περισσότερα »
Oral nucleos(t)ide analogues reduce recurrence and death in chronic hepatitis B-related hepatocellular carcinoma
Summary Background In patients with chronic hepatitis B (CHB)-related hepatocellular carcinoma (HCC), high viral load was associated with tumour recurrence and deaths. Aims To investigate the effect of nucleos(t)ide analogues (NA) on the clinical outcomes after different HCC treatments. Methods A territory-wide cohort study was conducted using the database from Hospital Authority. We identified CHB patients with HCC by International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnosis codes in 2000–2012. HCC treatments, NA use and laboratory pa... περισσότερα »
Editorial: serotonin and irritable bowel syndrome – reconciling pharmacological effects with basic biology
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Letter: gluten challenge in the era of noncoeliac gluten sensitivity – a change in clinical practice?
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Letter: the liver to abdominal area ratio – a novel imaging score for prognostication in cirrhosis
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Letter: abnormal bone densitometry in patients with coeliac disease - beyond malabsorption and sunlight exposure
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Editorial: proton pump inhibitors, Helicobacter pylori and gastric cancer – the need for long-term follow-up
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Letter: nucleos(t)ide analogues are good, but not sufficient for hepatitis B virus clearance
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Editorial: fenofibrate as second-line therapy in high risk PBC – more answers or more questions?
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Editorial: can MRI enterography be an efficient tool for patient selection in clinical trials?
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Editorial: improved understanding of the epidemiology of primary biliary cirrhosis in South Korea
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Editorial: fenofibrate as second-line therapy in high risk PBC – more answers or more questions? Authors' reply
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Editorial: how to interpret risks and prediction of complications in Crohn's disease – can our patients interpret them?
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Letter: the liver to abdominal area ratio – a novel imaging score for prognostication in cirrhosis – authors' reply
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Letter: gluten challenge in the era of noncoeliac gluten sensitivity – a change in clinical practice? Author's reply
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Widespread metachronous carcinoid tumour metastases to the head and neck: a unique presentation
Widespread metachronous carcinoid tumour metastases to the head and neck: a unique presentation: Carcinoid tumours are usually slow-growing, neuroendocrine neoplasms that primarily affect the gastrointestinal tract and bronchial tree. Although relatively rare, isolated, single metastasis to the head and neck has been reported. We present a unique case of 6 metachronous carcinoid metastases to both parotid glands, the left submandibular gland, upper lip, and thyroid, over 3 years. To our knowledge, this widespread presentation in the head and neck has not previously been reported.
Pre-existing asthma may be a strong predictor of future chronic migraine attacks
ASTHMA a Predictor of CHRONIC MIGRAINE ATTACKS: Pre-existing asthma may be a strong predictor of future chronic migraine attacks in individuals experiencing occasional migraine headaches, according to researchers from the University of Cincinnati (UC), Montefiore Headache Center and Albert Einstein College of Medicine, and Vedanta Research. The findings were published online in November in the journal *Headache*, a publication of the American Headache Society. “If you have asthma along with episodic or occasional migraine, then your headaches are more likely to evolve into a more di...περισσότερα »
Norman E. McSwain, Jr., MD, FACS: (1937-2015).
No abstract available from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1R4IeY6 via IFTTT
Phenotypic Heterogeneity in a DFNA20/26 family segregating a novel ACTG1 mutation.
Phenotypic Heterogeneity in a DFNA20/26 family segregating a novel ACTG1 mutation Authors: Yuan Y, Gao X, Huang B, Lu J, Wang G, Lin X, Qu Y, Dai P Abstract BACKGROUND: Genetic factors play an important role in hearing loss, contributing to approximately 60 % of cases of congenital hearing loss. Autosomal dominant deafness accounts for approximately 20 % of cases of hereditary hearing loss. Diseases with autosomal dominant inheritance often show pleiotropy, different degrees of penetrance, and variable expressivity. METHODS: A three-generation Chinese family with autosomal dominant... περισσότερα »
Clinical Practice Guideline: Otitis Media with Effusion (Update).
Clinical Practice Guideline: Otitis Media with Effusion (Update) Authors: Rosenfeld RM, Shin JJ, Schwartz SR, Coggins R, Gagnon L, Hackell JM, Hoelting D, Hunter LL, Kummer AW, Payne SC, Poe DS, Veling M, Vila PM, Walsh SA, Corrigan MD Abstract OBJECTIVE: This update of a 2004 guideline codeveloped by the American Academy of Otolaryngology-Head and Neck Surgery Foundation, the American Academy of Pediatrics, and the American Academy of Family Physicians, provides evidence-based recommendations to manage otitis media with effusion (OME), defined as the presence of fluid in the middl... περισσότερα »
KTP vs CO2 Laser for the Treatment of Laryngeal Carcinoma
KTP vs CO2 Laser for the Treatment of Laryngeal Carcinoma: *Condition*: Laryngeal Neoplasms *Interventions*: Device: CO2 laser; Device: KTP laser *Sponsor*: Kaplan Medical Center ArmsAssigned Interventions Active Comparator: CO2 laser Patients undergoing endoscopic treatment with CO2 laser Device: CO2 laser surgical removal of carcinoma from the vocal cords with CO2 laser Active Comparator: KTP laser Patients undergoing endoscopic treatment with KTP laser Device: KTP laser surgical removal of carcinoma from the vocal cords with KTP laser Detailed Description: Randomized contr...περισσότερα »
Standardized letters of recommendation and successful match into otolaryngology
Standardized letters of recommendation and successful match into otolaryngology: Objectives/Hypothesis Historically, narrative letters of recommendation have been utilized in the selection of applicants for otolaryngology residency programs. In the last two application cycles, our specialty adopted a standardized letter of recommendation (SLOR). The intent was to decrease time burden for letter writers and to provide readers with an objective evaluation of applicants. The objective of this study was to determine attributes in the SLOR that correlate with matching into a residency p... περισσότερα »
KTP vs CO2 Laser for the Treatment of Laryngeal Carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
KTP vs CO2 Laser for the Treatment of Laryngeal Carcinoma: *Condition*: Laryngeal Neoplasms *Interventions*: Device: CO2 laser; Device: KTP laser *Sponsor*: Kaplan Medical Center ArmsAssigned Interventions Active Comparator: CO2 laser Patients undergoing endoscopic treatment with CO2 laser Device: CO2 laser surgical removal of carcinoma from the vocal cords with CO2 laser Active Comparator: KTP laser Patients undergoing endoscopic treatment with KTP laser Device: KTP laser surgical removal of carcinoma from the vocal cords with KTP laser Detailed Description: Randomized... περισσότερα »
High-grade histology as predictor of early distant metastases and decreased disease-free survival in salivary gland cancer irrespective of tumor subtype
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
High-grade histology as predictor of early distant metastases and decreased disease-free survival in salivary gland cancer irrespective of tumor subtype: ABSTRACT Background The purpose of this study was to evaluate risk factors that influence overall survival (OS)/disease-free survival (DFS)/locoregional recurrence-free survival (LRFS), and distant metastases-free survival (DMFS) in patients with high-risk primary salivary gland carcinoma who underwent surgery and postoperative (chemo)radiotherapy with curative intention. Methods We reviewed data of 63 patients with high-risk prim... περισσότερα »
High-grade histology as predictor of early distant metastases and decreased disease-free survival in salivary gland cancer irrespective of tumor subtype
High-grade histology as predictor of early distant metastases and decreased disease-free survival in salivary gland cancer irrespective of tumor subtype: ABSTRACT Background The purpose of this study was to evaluate risk factors that influence overall survival (OS)/disease-free survival (DFS)/locoregional recurrence-free survival (LRFS), and distant metastases-free survival (DMFS) in patients with high-risk primary salivary gland carcinoma who underwent surgery and postoperative (chemo)radiotherapy with curative intention. Methods We reviewed data of 63 patients with high-risk prim... περισσότερα »
High-grade malignant transformation of a radiation-naïve nasopharyngeal angiofibroma
High-grade malignant transformation of a radiation-naïve nasopharyngeal angiofibroma: Abstract Background Nasopharyngeal angiofibromas are typically considered benign vascular neoplasms, with descriptions of high-grade sarcomatous change found only in lesions with prior radiotherapy. Methods and Results We describe the first reported case of high-grade malignant change in a nasopharyngeal angiofibroma naive to radiation. A 45-year-old man presented with left-sided nasal congestion and fullness and was found to have a left-sided nasopharyngeal mass with intracranial extension on CT s... περισσότερα »
High-grade malignant transformation of a radiation-naïve nasopharyngeal angiofibroma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα
High-grade malignant transformation of a radiation-naïve nasopharyngeal angiofibroma: Abstract Background Nasopharyngeal angiofibromas are typically considered benign vascular neoplasms, with descriptions of high-grade sarcomatous change found only in lesions with prior radiotherapy. Methods and Results We describe the first reported case of high-grade malignant change in a nasopharyngeal angiofibroma naive to radiation. A 45-year-old man presented with left-sided nasal congestion and fullness and was found to have a left-sided nasopharyngeal mass with intracranial extension on CT s... περισσότερα »
Therapeutic doses of TRIAC in Mct8KO mice restored plasma T3 levels but severely decreased T4 levels. Effect of Triiodothyroacetic Acid Treatment in Mct8 Deficiency: A Word of Caution
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα
Effect of Triiodothyroacetic Acid Treatment in Mct8 Deficiency: A Word of Caution: Thyroid , Vol. 0, No. 0. Author information Soledad Bárez-López,1,2 Maria Jesus Obregon,1 Raquel Martínez-de-Mena,1 Juan Bernal,1,2 Ana Guadaño-Ferraz,1,2 and Beatriz Morte1,2 1Department of Endocrine and Nervous System Pathophysiology, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid,Spain. 2Department of Endocrine, U-708, Center for Biomedical Research on Rare Diseases (Ciberer), Instituto de S... περισσότερα »
Impedance Changes and Fibrous Tissue Growth after Cochlear Implantation Are Correlated and Can Be Reduced Using a Dexamethasone Eluting Electrode
Impedance Changes and Fibrous Tissue Growth after Cochlear Implantation Are Correlated and Can Be Reduced Using a Dexamethasone Eluting Electrode: by Maciej Wilk, Roland Hessler, Kenneth Mugridge, Claude Jolly, Michael Fehr, Thomas Lenarz, Verena Scheper Background The efficiency of cochlear implants (CIs) is affected by postoperative connective tissue growth around the electrode array. This tissue formation is thought to be the cause behind post-operative increases in impedance. Dexamethasone (DEX) eluting CIs may reduce fibrous tissue growth around the electrode array subsequen...περισσότερα »
Exacerbation of headache during dihydroergotamine for chronic migraine does not alter outcome
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Objective: To evaluate whether headache exacerbation associated with IV dihydroergotamine (DHE) infusion predicts medium-term headache outcome in patients with chronic migraine. Methods: This was a retrospective chart review study of the UCSF Headache Center’s use of IV DHE for chronic migraine from 2008 to 2012. Medium-term headache outcome was assessed at 6-week follow-up. Univariate and […]
Amyloid pathology and axonal injury after brain trauma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Objective: To image β-amyloid (Aβ) plaque burden in long-term survivors of traumatic brain injury (TBI), test whether traumatic axonal injury and Aβ are correlated, and compare the spatial distribution of Aβ to Alzheimer disease (AD). Methods: Patients 11 months to 17 years after moderate–severe TBI underwent 11C-Pittsburgh compound B (11C-PiB)-PET, structural and diffusion MRI, and […]
Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Objective: We report the clinical and serologic features of Japanese patients with chronic inflammatory demyelinating polyneuropathy (CIDP) displaying anti-neurofascin-155 (NF155) immunoglobulin G4 (IgG4) antibodies. Methods: In sera from 533 patients with CIDP, anti-NF155 IgG4 antibodies were detected by ELISA. Binding of IgG antibodies to central and peripheral nerves was tested. Results: Anti-NF155 IgG4 antibodies were […]
Ist Ihr Patient fahrtauglich?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Verkehrssicherheit Wann ist die „Fahreignung“ bzw. „Fahrtauglichkeit“ von Patienten, die Psychopharmaka einnehmen und/oder an Demenz, Depressionen oder schizophrenen Psychosen leiden, in Frage zu stellen? Ein Überblick. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1X4QdVH via IFTTT
A novel epigenetic signature for early diagnosis in lung cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
PURPOSE: Lung cancer remains as the leading cause of cancer-related death worldwide, mainly due to late diagnosis. Cytology is the gold standard method for lung cancer diagnosis in minimally-invasive respiratory samples, despite its low sensitivity. We aimed to identify epigenetic biomarkers with clinical utility for cancer diagnosis in minimally/non-invasive specimens to improve accuracy of current […]
Immune Signatures Following Single Dose Trastuzumab Predict Pathologic Response to Preoperative Trastuzumab and Chemotherapy in HER2-Positive Early Breast Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Purpose: Recent data suggest that intrinsic subtype and immune cell infiltration may predict response to trastuzumab-based therapy. We studied the interaction between these factors, changes in immune signatures following brief-exposure to trastuzumab and achievement of pathologic complete response (pCR) to subsequent preoperative trastuzumab and chemotherapy in HER2-positive breast cancer. Experimental Design: In patients enrolled on […]
The Role of Neoadjuvant Trials in Drug Development for Solid Tumors
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
The relatively low success rate of phase II oncology trials in predicting success of novel drugs in phase III trials and in gaining regulatory approval may be due to reliance on the endpoint of response rate defined by the Response Evaluation Criteria in Solid Tumors (RECIST). The neoadjuvant treatment paradigm allows the anti-tumor activity of […]
Phase I safety, pharmacokinetic and pharmacodynamic study of the poly (ADP-ribose) polymerase inhibitor veliparib with irinotecan in patients with advanced tumors
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Background: Poly (ADP-ribose) polymerase (PARP) is essential for recognition and repair of DNA damage. In preclinical models, PARP inhibitors modulate topoisomerase I inhibitormediated DNA damage. This Phase I study determined the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), pharmacokinetics (PK) and pharmacodynamics (PD) of veliparib, an orally-bioavailable PARP 1/2 inhibitor, in combination with irinotecan. Methods: […]
Of Mice and Melanoma: PDX System for Modeling Personalized Medicine
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Targeted therapies have advanced the treatment options for cutaneous melanoma but many patients will progress on drug. Patient-derived xenografts (PDX) can be used to recapitulate therapy resistant tumors. Furthermore, PDX modeling can be utilized in combination with targeted sequencing and phospho-proteomic platforms providing pre-clinical basis for second-line targeted inhibitor strategies. from #Medicine-SfakianakisAlexandros via o.lakala70 on […]
Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53 IMMUNE SYSTEM DEVELOPMENT
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Yin Yang 1 (YY1) is a zinc finger protein that functions as a transcriptional activator or repressor and participates in multiple biological processes, including development and tumorigenesis. To investigate the role of YY1 in developing T cells, we used mouse models that depleted YY1 at two distinct stages of thymocyte development. When YY1 was depleted […]
ATA-Endorsed Guidelines and Expert Panel Report on Managing Thyroid Nodules and Differentiated Thyroid Cancer in Adults
*ATA-Endorsed Guidelines and Expert Panel Report on Managing Thyroid Nodules and Differentiated Thyroid Cancer in Adults: * *We are pleased to present:* *The final, fully edited version of the official 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer from The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer* *An Expert Panel Discussion, sponsored by Rosetta Genomics, lead by Brian Huagen, University of Colorado School of Medicine, that explores the... περισσότερα »
Ablative fractional photothermolysis
Effects of deviation from focal plane on lesion geometry for ablative fractional photothermolysis: Background and Objective Fractional Photothermolysis (FP) is a method of skin treatment that generates a thermal damage pattern consisting of multiple columns of thermal damage, also known as microscopic treatment zones (MTZs). They are very small in diameter and are generated by application of highly focused laser beams. In order to obtain the smallest spot size, the treatment should be performed in the focal plane. Any deviation from the focal plane (DFP) results in an increase of s... περισσότερα »
Epithelial discrimination of commensal and pathogenic Candida albicans
Epithelial discrimination of commensal and pathogenic Candida albicans: All mucosal surfaces are lined by epithelial cells and are colonised by opportunistic microbes. In health, these opportunistic microbes remain commensal and are tolerated by the immune system. However, when the correct environmental conditions arise, these microbes can become pathogenic and need to be controlled or cleared by the immune system to prevent disease. The mechanisms that enable epithelial cells to initiate the ‘danger’ signals activated specifically by pathogenic microbes are critical to mucosal def... περισσότερα »
Relationship between processing score and kernel-fraction particle size in whole-plant corn silage
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Publication date: Available online 3 February 2016 Source:Journal of Dairy Science Author(s): G.S. Dias Junior, L.F. Ferraretto, G.G.S. Salvati, L.C. de Resende, P.C. Hoffman, M.N. Pereira, R.D. Shaver Kernel processing increases starch digestibility in whole-plant corn silage (WPCS). Corn silage processing score (CSPS), the percentage of starch passing through a 4.75-mm sieve, is widely used […]
Effective lactation yield: A measure to compare milk yield between cows with different dry period lengths
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Publication date: Available online 3 February 2016 Source:Journal of Dairy Science Author(s): A. Kok, C.E. van Middelaar, B. Engel, A.T.M. van Knegsel, H. Hogeveen, B. Kemp, I.J.M. de Boer To compare milk yields between cows or management strategies, lactations are traditionally standardized to 305-d yields. The 305-d yield, however, gives no insight into the combined […]
Amyloid plaques in TBI: Incidental finding or precursor for what is to come?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Over the past decade, the rate of traumatic brain injury (TBI)-related emergency department visits has increased by 70% and was estimated in 2010 at a staggering 2.5 million visits. This number is an underestimate as it does not include individuals who did not seek/receive medical care, are part of the US military service, or cared […]
Bedside tests to predict laryngoscopic difficulty in pediatric patients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Bedside tests to predict laryngoscopic difficulty in pediatric patients: Pediatric airway management is a priority during anesthesia, critical care and emergency medicine. The purpose of this study is to validate bedside tests that predict airway management difficulty in anesthetized children. ABSTRACT BACKGROUND AND OBJECTIVES Pediatric airway management is a priority during anesthesia, critical care and […]
Outcomes of migraine therapy with IV dihydroergotamine
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
IV dihydroergotamine (DHE) is a widely used treatment for status migrainosus or refractory chronic migraine, but there are few published studies on outcomes of this therapy.1 The report by Eller et al.2 adds to our current understanding of the effects of DHE, with a thorough description of their experience at an academic inpatient headache unit. […]
Low level laser therapy (LLLT) has been noted to be effective in mitigating the development of oral mucositis among patients being treated with chemoradiation for cancers of the head and neck
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Could the biological robustness of low level laser therapy (Photobiomodulation) impact its use in the management of mucositis in head and neck cancer patients via ScienceDirect Publication: Oral Oncology Publication date: Available online 3 February 2016 Source:Oral Oncology Author(s): Stephen T. Sonis, Sepehr Hashemi, Joel B. Epstein, Raj G. Nair, Judith E. Raber-Durlacher Low level […]
CSTB null mutation associated with microcephaly, early developmental delay, and severe dyskinesia
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
The CSTB gene encodes for cystatin B, an inhibitor of lysosomal cysteine protease (cathepsins B, H, L, and S).1CSTB mutations have been associated with type 1 progressive myoclonic epilepsy, also known as Unverricht-Lundborg (ULD) disease, or Baltic myoclonus.2,3 A total of 90% of all disease alleles consists of an expansion of at least 30 times […]
Clinical Report: Cognitive decline in a patient with Cardiofaciocutaneous syndrome
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Cardiofaciocutaneous Syndrome (CFCS) is a rare genetic syndrome caused by mutations in one of four genes: BRAF, MAP2K1, MAP2K2, and KRAS. There is tremendous phenotypic heterogeneity in patients with CFCS and so confirmation of diagnosis requires genetic testing. Neurologic and/or cognitive symptoms are present in almost all CFCS individuals. Little is known about cognitive function […]
Exacerbation of headache during dihydroergotamine for chronic migraine does not alter outcome
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Objective: To evaluate whether headache exacerbation associated with IV dihydroergotamine (DHE) infusion predicts medium-term headache outcome in patients with chronic migraine. Methods: This was a retrospective chart review study of the UCSF Headache Center’s use of IV DHE for chronic migraine from 2008 to 2012. Medium-term headache outcome was assessed at 6-week follow-up. Univariate and […]
ADAT3-related intellectual disability: Further delineation of the phenotype
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
ADAT3-related intellectual disability has been recently described in 24 individuals from eight Saudi families who had cognitive impairment and strabismus. Other common features included growth failure, microcephaly, tone abnormalities, epilepsy, and nonspecific brain abnormalities. A single homozygous founder mutation (c.382G>A:p.(V128M)) in the ADAT3 gene, which encodes a protein that functions in tRNA editing, was identified […]
Bedside tests to predict laryngoscopic difficulty in pediatric patients
Bedside tests to predict laryngoscopic difficulty in pediatric patients: Pediatric airway management is a priority during anesthesia, critical care and emergency medicine. The purpose of this study is to validate bedside tests that predict airway management difficulty in anesthetized children. ABSTRACTBACKGROUND AND OBJECTIVES Pediatric airway management is a priority during anesthesia, critical care and emergency medicine. The purpose of this study is to validate bedside tests that predict airway management difficulty in anesthetized children. METHODS Children under 12 years of ag...περισσότερα »
Low level laser therapy (LLLT) has been noted to be effective in mitigating the development of oral mucositis among patients being treated with chemoradiation for cancers of the head and neck
Could the biological robustness of low level laser therapy (Photobiomodulation) impact its use in the management of mucositis in head and neck cancer patients via ScienceDirect Publication: Oral Oncology Publication date: Available online 3 February 2016 *Source:*Oral Oncology Author(s): Stephen T. Sonis, Sepehr Hashemi, Joel B. Epstein, Raj G. Nair, Judith E. Raber-Durlacher Low level laser therapy (LLLT) has been noted to be effective in mitigating the development of oral mucositis among patients being treated with chemoradiation for cancers of the head and neck. To explain the biolo...περισσότερα »
Bosma arhina microphthalmia syndrome: Clinical report and review of the literature
Bosma arhinia microphthalmia syndrome (Bosma syndrome)(OMIM 603457) is a congenital condition characterized by microphthalmia with coloboma, arhinia and endocrine findings in the setting of normal intelligence and brain structure. This condition is quite rare with fewer than 50 case reports and series. Although pathogenesis is presumed to be genetic, the cause remains unknown. We report an individual with Bosma syndrome who had bilateral colobomatous microphthalmia, arhinia, high arched palate, mild ear malformations, and hypogonadotropic hypogonadism requiring growth hormone tre...περισσότερα »
Clinical Report: Cognitive decline in a patient with Cardiofaciocutaneous syndrome
Cardiofaciocutaneous Syndrome (CFCS) is a rare genetic syndrome caused by mutations in one of four genes: *BRAF*, *MAP2K1*, *MAP2K2*, and *KRAS*. There is tremendous phenotypic heterogeneity in patients with CFCS and so confirmation of diagnosis requires genetic testing. Neurologic and/or cognitive symptoms are present in almost all CFCS individuals. Little is known about cognitive function in older patients with CFCS. In this report, we present the cognitive, neuropsychiatric, and imaging findings of a patient diagnosed with CFCS who after having remained stable developed progre... περισσότερα »
ADAT3-related intellectual disability: Further delineation of the phenotype
ADAT3-related intellectual disability has been recently described in 24 individuals from eight Saudi families who had cognitive impairment and strabismus. Other common features included growth failure, microcephaly, tone abnormalities, epilepsy, and nonspecific brain abnormalities. A single homozygous founder mutation (c.382G>A:p.(V128M)) in the *ADAT3* gene, which encodes a protein that functions in tRNA editing, was identified in all affected individuals. In this report, we present additional 15 individuals from 11 families (10 Saudis and 1 Emirati) who are homozygous for the sa...περισσότερα »
Prevention of Iodine Deficiency Disorders
•Ensuring Effective Prevention of Iodine Deficiency Disorders Thyroid (doi:10.1089/thy.2015.0543) View Table of Contents | [image: RSS] TOC, Citation What is RSS? | Email Alert Author information Henry Völzke,1 Philippe Caron,2 Lisbeth Dahl,3 João J. de Castro,4 Iris Erlund,5 Simona Gaberšček,6Ingibjörg Gunnarsdottir,7 Alicja Hubalewska-Dydejczyk,8 Till Ittermann,1 Ludmila Ivanova,9 Borislav Karanfilski,10 Rehman M. Khattak,1 Zvonko Kusić,11 Peter Laurberg,12 John H. Lazarus,13 Kostas B. Markou,14 Rodrigo Moreno-Reyes,15 Endre V. Nagy,16 Robin P. Peeters,17 Valdis Pīrāgs,18 Ján Po...περισσότερα »
Serum Thyrotropin and Thyroid Autoantibody Change
•Parity and 11-Year Serum Thyrotropin and Thyroid Autoantibody Change: A Longitudinal Population-Based Study Thyroid (doi:10.1089/thy.2014.0279) View Table of Contents | [image: RSS] TOC, Citation What is RSS? | Email Alert Author information Lena Bjergved,1,2 Allan Carlé,3 Torben Jørgensen,1,4,5 Hans Perrild,2 Peter Laurberg,3,5 Anne Krejbjerg,3 Lars Ovesen,6 Inge Bülow Pedersen,3 Lone Banke Rasmussen,7 and Nils Knudsen2 1Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark. 2Department of Endocrinology, Bispebjerg University Hospital, Copenh... περισσότερα »
Triiodothyroacetic Acid Treatment in Mct8 Deficiency
•Effect of Triiodothyroacetic Acid Treatment in Mct8 Deficiency: A Word of Caution Thyroid Posted online on February 3, 2016. (doi:10.1089/thy.2015.0388) View Table of Contents | [image: RSS] TOC, Citation What is RSS? | Email Alert Author information Soledad Bárez-López,1,2 Maria Jesus Obregon,1 Raquel Martínez-de-Mena,1 Juan Bernal,1,2 Ana Guadaño-Ferraz,1,2 and Beatriz Morte1,2 1Department of Endocrine and Nervous System Pathophysiology, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UA... περισσότερα »
Effects of Levothyroxine Replacement or Suppressive Therapy on Energy Expenditure and Body Composition
Effects of Levothyroxine Replacement or Suppressive Therapy on Energy Expenditure and Body Composition: Thyroid , Vol. 0, No. 0. Author information Mary H. Samuels,1 Irina Kolobova,1 Anne Smeraglio,2 Dawn Peters,3 Jonathan Q. Purnell,1 andKathryn G. Schuff1 1Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon. 2Department of Internal Medicine, Stanford University School of Medicine, Stanford, California. 3Division of Biostatistics, Oregon Health and Science University, Portland, Oregon. Address correspondence to: *Mary... περισσότερα »
Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas
Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas: Intraocular medulloepithelioma (IO-MEPL) is an uncommon embryonal neuroepithelial neoplasm of the eye. Little is known about the cytogenetics, molecular biology, and pathogenesis of this tumor. In the present study we investigated the mutational landscape of 19 IO-MEPL using targeted next-generation sequencing. Routinely prepared paraffin-embedded samples were assessed with high-coverage genome sequencing on the Illumina NextSeq 500 platform using a customized gene panel set covering the coding ... περισσότερα »
Intraocular medulloepitheliomas
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas: Intraocular medulloepithelioma (IO-MEPL) is an uncommon embryonal neuroepithelial neoplasm of the eye. Little is known about the cytogenetics, molecular biology, and pathogenesis of this tumor. In the present study we investigated the mutational landscape of 19 IO-MEPL using targeted next-generation sequencing. Routinely prepared paraffin-embedded samples were assessed with high-coverage genome sequencing on the Illumina NextSeq 500 platform using a customized gene panel set covering the coding ... περισσότερα »
On patient safety, teams and psychologically disturbed pilots
No abstract available from Anaesthesia via ola Kala on Inoreader http://ift.tt/1nFS1YW via IFTTT
Current issues in postoperative pain management
[image: image]Postoperative pain has been poorly managed for decades. Recent surveys from USA and Europe do not show any major improvement. Persistent postoperative pain is common after most surgical procedures, and after thoracotomy and mastectomy, about 50% of patients may experience it. Opioids remain the mainstay of postoperative pain treatment in spite of strong evidence of their drawbacks. Multimodal analgesic techniques are widely used but new evidence is disappointing. Regional anaesthetic techniques are the most effective methods to treat postoperative pain. Current evidenc... περισσότερα »
Perioperative management of nail polish, artificial nails and piercings in The Netherlands: A survey study
[image: image]No abstract available from Anaesthesia via ola Kala on Inoreader http://ift.tt/1nFS2fn via IFTTT
Implementing situation-background-assessment-recommendation in an anaesthetic clinic and subsequent information retention among receivers: A prospective interventional study of postoperative handovers
[image: image]BACKGROUND: Communication errors cause clinical incidents and adverse events in relation to surgery. To ensure proper postoperative patient care, it is essential that personnel remember and recall information given during the handover from the operating theatre to the postanaesthesia care unit. Formalizing the handover may improve communication and aid memory, but research in this area is lacking. OBJECTIVE: The objective of this study was to evaluate whether implementing the communication tool Situation-Background-Assessment-Recommendation (SBAR) affects receivers' in...περισσότερα »
Multiple Choice Questions
Publication date: February 2016 *Source:*European Journal of Vascular and Endovascular Surgery, Volume 51, Issue 2 from Endocrinology via ola Kala on Inoreader http://ift.tt/1o887Lq via IFTTT
Contents
Publication date: February 2016 *Source:*European Journal of Vascular and Endovascular Surgery, Volume 51, Issue 2 from Endocrinology via ola Kala on Inoreader http://ift.tt/1o885D5 via IFTTT
Editorial Board
Publication date: February 2016 *Source:*European Journal of Vascular and Endovascular Surgery, Volume 51, Issue 2 from Endocrinology via ola Kala on Inoreader http://ift.tt/1mf0X6m via IFTTT
Selected Abstracts from the February Issue of the Journal of Vascular Surgery
Publication date: February 2016 *Source:*European Journal of Vascular and Endovascular Surgery, Volume 51, Issue 2 from Endocrinology via ola Kala on Inoreader http://ift.tt/1o8856i via IFTTT
Dive, food and exercise effects on blood microparticles in Steller sea lions (Eumetopias jubatus): exploring a biomarker for decompression sickness.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Recent studies of stranded marine mammals indicate that exposure to underwater military sonar may induce pathophysiological responses consistent with decompression sickness (DCS). However, DCS has been difficult to diagnose in marine mammals. We investigated whether blood microparticles (MPs, measured as number/μl plasma), which increase in response to decompression stress in terrestrial mammals, are a suitable […]
The Lifetime Contributions of Timothy Bartness to the Study of Obesity
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
none from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1P8m98x via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Electrical stimulation of the aortic depressor nerve in conscious rats overcomes the attenuation of the baroreflex in chronic heart failure.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Chronic heart failure (CHF) is characterized by autonomic dysfunction combined with baroreflex attenuation. The hypotensive and bradycardic responses produced by electrical stimulation of the aortic depressor nerve (ADN) were examined in conscious CHF and control male Wistar rats (12-13 weeks old). Furthermore, the role of parasympathetic and sympathetic nervous system in mediating the cardiovascular responses […]
Weak signal amplification and detection by higher-order sensory neurons
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Sensory systems must extract behaviorally relevant information and therefore often exhibit a very high sensitivity. How the nervous system reaches such high sensitivity levels is an outstanding question in neuroscience. Weakly electric fish (Apteronotus leptorhynchus/albifrons) are an excellent model system to address this question because detailed background knowledge is available regarding their behavioral performance and […]
Neural spike-timing patterns vary with sound shape and periodicity in three auditory cortical fields
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Mammals perceive a wide range of temporal cues in natural sounds, and the auditory cortex is essential for their detection and discrimination. The rat primary (A1), ventral (VAF), and caudal suprarhinal (cSRAF) auditory cortical fields have separate thalamocortical pathways that may support unique temporal cue sensitivities. To explore this, we record responses of single neurons […]
G{alpha}14 subunit-mediated inhibtion of voltage-gated Ca2+ and K+ channels via neurokinin-1 receptor in celiac-superior mesenteric ganglion neurons
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The mechanisms by which G proteins modulate voltage-gated Ca2+ channel currents (CaV), particulary CaV2.2 and CaV2.3, are voltage-dependent (VD) or voltage-independent (VI). VD pathways are typically mediated by Gαi/o and GαS subfamilies. On the other hand, VI inhibition signaling is coupled to the Gαq subfamily and signaling pathways downstream of phospholipase C stimulation. In most […]
Primary motor cortex neurons classified in a postural task predict muscle activation patterns in a reaching task
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Primary motor cortex (M1) activity correlates with many motor variables making it difficult to demonstrate how it participates in motor control. We developed a two-stage process to separate the process of classifying the motor field of M1 neurons from the process of predicting the spatiotemporal patterns of its motor field during reaching. We tested our […]
Temporal Accuracy of Human Cortico-Cortical Interactions
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The precision in space and time of interactions among multiple cortical sites was evaluated by examining repeating precise spatio-temporal patterns of instances in which cortical currents showed brief amplitude undulations. The amplitudes of the cortical current dipoles were estimated by applying a variant of synthetic aperture magnometry to MEG recordings of subjects tapping to metric […]
Neural timing signal for precise tactile timing judgments
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The brain can precisely encodes the temporal relationship between tactile inputs. While behavioural studies have demonstrated precise inter-finger temporal judgments, the underlying neural mechanism remains unknown. Computationally, two kinds of neural responses can act as the information source. One is the phase-locked response to the phase of relatively slow inputs, and the other is the […]
Model systems for studying cellular mechanisms of SCN1A related epilepsy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Mutations in SCN1A, the gene encoding NaV1.1 sodium channels, cause a spectrum of epilepsy disorders that range from genetic epilepsy with febrile seizures plus (GEFS+) to catastrophic disorders like Dravet Syndrome (DS). To date, more than 1250 mutations in SCN1A have been linked to epilepsy. Distinct effects of individual SCN1A mutations on neuronal function are […]
The dynamic interdependence between family support and depressive symptoms among adolescents in Ghana
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives This study identified temporal sequencing in the associations between family support and depressive symptoms over the course of adolescence for youth in Ghana. Methods Data derived from a longitudinal cohort study of 718 Ghanaian adolescents (58 % female) who were, on average, 13.84 years at Wave 1. Youth completed surveys at three time […]
Does self-efficacy mediate the association between socioeconomic background and emotional symptoms among schoolchildren?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives Emotional symptoms are widespread among adolescents with the highest prevalence among lower socioeconomic groups. Less is known about why and how to reduce this inequality but personal control, e.g., self-efficacy may be crucial. This study examines whether self-efficacy is a mediator in the association between occupational social class (OSC) and emotional symptoms. Methods […]
Reactions to smoke-free public policies and smoke-free home policies in the Republic of Georgia: results from a 2014 national survey
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives We examined receptivity to public smoke-free policies and smoke-free home status among adults in the Republic of Georgia. Methods In Spring 2014, we conducted a national household survey of 1163 adults. Results Our sample was on average 42.4 years old, 51.1 % male, and 43.2 % urban. Current smoking prevalence was 54.2 % […]
Decreased smoking initiation among male youths in China: an urban–rural comparison
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives This study compared urban/rural differences in smoking initiation during the transition from adolescence to young adulthood among Chinese males. Methods Data were derived from the China Health and Nutrition Survey (N = 2395). Logistic and cox models were computed to assess smoking initiation between the ages of 15 and 20 across urban/rural administrative […]
Mapping immune cell infiltration using restricted diffusion MRI
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose Diffusion MRI provides a noninvasive way to assess tissue microstructure. Based on diffusion MRI, we propose a model-free method called restricted diffusion imaging (RDI) to quantify restricted diffusion and correlate it with cellularity. Theory and Methods An analytical relation between q-space signals and the density of restricted spins was derived to quantify restricted diffusion. […]
Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53 IMMUNE SYSTEM DEVELOPMENT
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Yin Yang 1 (YY1) is a zinc finger protein that functions as a transcriptional activator or repressor and participates in multiple biological processes, including development and tumorigenesis. To investigate the role of YY1 in developing T cells, we used mouse models that depleted YY1 at two distinct stages of thymocyte development. When YY1 was depleted […]
Retinoic Acid Receptor {gamma} Regulates B and T Lymphopoiesis via Nestin-Expressing Cells in the Bone Marrow and Thymic Microenvironments IMMUNE REGULATION
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Vitamin A has essential but largely unexplained roles in regulating lymphopoiesis. We have previously shown that retinoic acid receptor (RAR) –deficient mice have hematopoietic defects, some phenotypes of which were microenvironment induced. Bone marrow (BM) microenvironment cells identified by either their expression of nestin (Nes) or osterix (Osx) have previously been shown to have roles […]
Simulation unmasks deficit in the knowledge of the WHO checklist among junior anaesthetists: Simulation scenario and survey
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
No abstract available from Anaesthesia via ola Kala on Inoreader http://ift.tt/1nFS07d via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mfe0EZ via IFTTT
Thyroid hormone responsive (THRSP) promotes the synthesis of medium-chain fatty acids in goat mammary epithelial cells
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 3 February 2016 Source:Journal of Dairy Science Author(s): D.W. Yao, J. Luo, Q.Y. He, M. Wu, H.B. Shi, H. Wang, M. Wang, H.F. Xu, J.J. Loor In nonruminants, thyroid hormone responsive (THRSP) is a crucial protein for cellular de novo lipogenesis. However, the role of THRSP in regulating the synthesis of […]
Survival of Ig{alpha}-Deficient Mature B Cells Requires BAFF-R Function MOLECULAR AND STRUCTURAL IMMUNOLOGY
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Expression of a functional BCR is essential for the development of mature B cells and has been invoked in the control of their maintenance. To test this maintenance function in a new experimental setting, we used the tamoxifen-inducible mb1-CreERT2 mouse strain to delete or truncate either the mb-1 gene encoding the BCR signaling subunit Igα […]
Is calcitonin an active hormone in the onset and prevention of hypocalcemia in dairy cattle?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 3 February 2016 Source:Journal of Dairy Science Author(s): E.M. Rodríguez, A. Bach, M. Devant, A. Aris The objective of this study was to assess the potential importance of calcitonin (CALC) in the onset of subclinical hypocalcemia (experiment 1) and in the physiological mechanisms underlying the prevention of bovine hypocalcemia under metabolic […]
Cutting Edge: Expression of IRF8 in Gastric Epithelial Cells Confers Protective Innate Immunity against Helicobacter pylori Infection CUTTING EDGE
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
IFN regulatory factor 8 (IRF8) is expressed in many types of blood cells and plays critical roles in cellular differentiation and function. However, the role of IRF8 in nonhematopoietic systems remains poorly understood. In this study, we provide evidence that IRF8 is a transcriptional modulator of the gastric mucosa necessary for limiting Helicobacter pylori colonization. […]
Relationship between processing score and kernel-fraction particle size in whole-plant corn silage
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 3 February 2016 Source:Journal of Dairy Science Author(s): G.S. Dias Junior, L.F. Ferraretto, G.G.S. Salvati, L.C. de Resende, P.C. Hoffman, M.N. Pereira, R.D. Shaver Kernel processing increases starch digestibility in whole-plant corn silage (WPCS). Corn silage processing score (CSPS), the percentage of starch passing through a 4.75-mm sieve, is widely used […]
The dynamic interdependence between family support and depressive symptoms among adolescents in Ghana
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Objectives This study identified temporal sequencing in the associations between family support and depressive symptoms over the course of adolescence for youth in Ghana. Methods Data derived from a longitudinal cohort study of 718 Ghanaian adolescents (58 % female) who were, on average, 13.84 years at Wave 1. Youth completed surveys at three time […]
Effective lactation yield: A measure to compare milk yield between cows with different dry period lengths
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 3 February 2016 Source:Journal of Dairy Science Author(s): A. Kok, C.E. van Middelaar, B. Engel, A.T.M. van Knegsel, H. Hogeveen, B. Kemp, I.J.M. de Boer To compare milk yields between cows or management strategies, lactations are traditionally standardized to 305-d yields. The 305-d yield, however, gives no insight into the combined […]
Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article Non-alcoholic fatty liver disease (NAFLD) is a risk factor for other types of liver diseases. Here, the authors integrate transcriptomic and metabolomic data from patients with NAFLD with a genome-scale metabolic model to paint a comprehensive picture of liver function in NAFLD. Nature Communications doi: 10.1038/ncomms9994 Authors: Tuulia Hyötyläinen, Livnat Jerby, Elina M. Petäjä, […]
Erratum: Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Erratum Nature Communications doi: 10.1038/ncomms10649 Authors: Hilary A. Kenny, Madhu Lal-Nag, Erin A. White, Min Shen, Chun-Yi Chiang, Anirban K. Mitra, Yilin Zhang, Marion Curtis, Elizabeth M. Schryver, Sam Bettis, Ajit Jadhav, Matthew B. Boxer, Zhuyin Li, Marc Ferrer, Ernst Lengyel from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SJjnJe via IFTTT
Steric interactions lead to collective tilting motion in the ribosome during mRNA–tRNA translocation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article During protein elongation, the translocation of mRNA and tRNA molecules across the 30S ribosomal subunit is associated with large-scale motions of the 30S head domain. Here the authors carry out MD simulations to probe the associated steric interactions and identify novel tilting motions during the late stages of translocation. Nature Communications doi: 10.1038/ncomms10586 Authors: […]
NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article During metaphase, alignment of chromosomes is facilitated by oscillations driven by the chromokinesin Kid. Here Li et al . show that the microtubule-associated protein NuSAP is a novel regulator of Kid, regulating the amplitude and velocity of chromosome oscillation. Nature Communications doi: 10.1038/ncomms10597 Authors: Chenyu Li, Chenyi Xue, Qiaoyun Yang, Boon Chuan Low, Yih-Cherng […]
The effect of a modified GlideScope intubation technique on procedure times, airway morbidity and haemodynamic response
[image: image]No abstract available from Anaesthesia via ola Kala on Inoreader http://ift.tt/1nFS1Io via IFTTT
Psychological distress, burnout and personality traits in Dutch anaesthesiologists: A survey
[image: image]BACKGROUND: The practice of anaesthesia comes with stress. If the demands of a stressful job exceed the resources of an individual, that person may develop burnout. Burnout poses a threat to the mental and physical health of the anaesthesiologist and therefore also to patient safety. OBJECTIVES: Individual differences in stress appraisal (perceived demands) are an important factor in the risk of developing burnout. To explore this possible relationship, we assessed the prevalence of psychological distress and burnout in the Dutch anaesthesiologist population and invest... περισσότερα »
Giant Cell Tumor of Bone With Pseudosarcomatous Changes Leading to Premature Denosumab Therapy Interruption: A Case Report With Review of the Literature
Denosumab has shown promising results in the management of giant cell tumor of bone, a primary bone tumor with locally aggressive behaviour. We report a case of premature denosumab interruption due to radiological and clinical tumor expansion of a giant cell tumor of the distal ulna. Although denosumab is known to induce tumor regression, with progressive ossification and loss of the characteristic morphology of giant cell tumor of bone, the ulnar tumor specimen showed a moderately to highly cellular proliferation of short spindle-shaped cells, and no osteoclast-like giant cells. ...περισσότερα »
Targeted Screening With Combined Age- and Morphology-Based Criteria Enriches Detection of Lynch Syndrome in Endometrial Cancer
Endometrial cancer is associated with Lynch syndrome in 2% to 6% of cases. Adequate screening may prevent of a second cancer and incident cancers in family members via risk-reducing strategies. The goal of the study was to evaluate the detection rate of Lynch syndrome via a targeted screening approach. In 2009, we incorporated targeted Lynch syndrome screening via immunohistochemistry for MLH1, PMS2, MSH2, and MSH6, followed by *MLH1* promoter hypermethylation, in select cases of endometrial carcinoma. Criteria for patient selection included (1) all patients <50 years; (2) patient...περισσότερα »
Letter: effectiveness of golimumab to induce remission in outpatient ulcerative colitis in Italy
from Pharmacology via ola Kala on Inoreader http://ift.tt/1JZplV7 via IFTTT
Editorial: how to interpret risks and prediction of complications in Crohn's disease – can our patients interpret them? Authors' reply
from Pharmacology via ola Kala on Inoreader http://ift.tt/1Qe1WvS via IFTTT
Letter: nucleos(t)ide analogues are good, but not sufficient for hepatitis B virus clearance – author's reply
from Pharmacology via ola Kala on Inoreader http://ift.tt/1Qe0fOW via IFTTT
Editorial: serotonin and irritable bowel syndrome – reconciling pharmacological effects with basic biology; authors' reply
from Pharmacology via ola Kala on Inoreader http://ift.tt/1R4oggj via IFTTT
Thyroid hormone responsive (THRSP) promotes the synthesis of medium-chain fatty acids in goat mammary epithelial cells
Publication date: Available online 3 February 2016 *Source:*Journal of Dairy Science Author(s): D.W. Yao, J. Luo, Q.Y. He, M. Wu, H.B. Shi, H. Wang, M. Wang, H.F. Xu, J.J. Loor In nonruminants, thyroid hormone responsive (THRSP) is a crucial protein for cellular de novo lipogenesis. However, the role of THRSP in regulating the synthesis of milk fatty acid composition in goat mammary gland remains unknown. In the present study, we compared gene expression of THRSP among different goat tissues. Results revealed that THRSP had the highest expression in subcutaneous fat, and expression ... περισσότερα »
Is calcitonin an active hormone in the onset and prevention of hypocalcemia in dairy cattle?
Publication date: Available online 3 February 2016 *Source:*Journal of Dairy Science Author(s): E.M. Rodríguez, A. Bach, M. Devant, A. Aris The objective of this study was to assess the potential importance of calcitonin (CALC) in the onset of subclinical hypocalcemia (experiment 1) and in the physiological mechanisms underlying the prevention of bovine hypocalcemia under metabolic acidosis (experiments 2 and 3). In experiment 1, 15 Holstein cows naturally incurring subclinical hypocalcemia during the first 5 d postpartum were classified as low subclinical hypocalcemia (LSH) when bl...περισσότερα »
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial
[image: image]BACKGROUND: α2-Agonists are used postoperatively as a component of multimodal analgesia. Tizanidine is a centrally acting α2-agonist with muscle relaxant properties. OBJECTIVE: The aim of this study was to compare the efficacy of tizanidine with placebo in terms of postoperative pain scores, analgesic consumption, return to daily activity and health-related quality of life. DESIGN: A randomised double-blind study. SETTING: Diskapi Yildirim Beyazit Training and Research Hospital. INTERVENTIONS: After obtaining ethical approval and informed patient consent, 60 patients u...περισσότερα »
High rate of burnout among anaesthesiologists in Belgrade teaching hospitals: Results of a cross-sectional survey
[image: image]BACKGROUND: Decisions by anaesthesiologists directly impact the treatment, safety, recovery and quality of life of patients. Physical or mental collapse due to overwork or stress (burnout) in anaesthesiologists may, therefore, be expected to negatively affect patients, departments, healthcare facilities and families. OBJECTIVES: To evaluate the prevalence of burnout among anaesthesiologists in Belgrade public teaching hospitals. DESIGN: A cross-sectional survey. SETTING: Anaesthesiologists in 10 Belgrade teaching hospitals. MAIN OUTCOME MEASURES: Burnout was assessed u... περισσότερα »
Simulation unmasks deficit in the knowledge of the WHO checklist among junior anaesthetists: Simulation scenario and survey
[image: image]No abstract available from Anaesthesia via ola Kala on Inoreader http://ift.tt/1nFS07d via IFTTT
Widespread metachronous carcinoid tumour metastases to the head and neck: a unique presentation
Carcinoid tumours are usually slow-growing, neuroendocrine neoplasms that primarily affect the gastrointestinal tract and bronchial tree. Although relatively rare, isolated, single metastasis to the head and neck has been reported. We present a unique case of 6 metachronous carcinoid metastases to both parotid glands, the left submandibular gland, upper lip, and thyroid, over 3 years. To our knowledge, this widespread presentation in the head and neck has not previously been reported. from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1PBr8jq via IFTTT
Validation of a technique for integration of a digital dental model into stereophotogrammetric images of the face using cone-beam computed tomographic data
We wanted to find and validate a new way to visualise patients' faces and their dental arches non-invasively. The stereophotogrammetric images of the faces and the digitised dental casts of seven healthy subjects were analysed. Point-based and surface-based recording techniques matched the facial image with those of the mandibular and maxillary dental arches in their relative positions. The cone-beam computed tomographic (CT) images of the same subjects were analysed retrospectively. Twenty-eight dentofacial distances were obtained on cone-beam CT images and on the recorded facial ...περισσότερα »
Absence of a spin-signature from a single Ho adatom as probed by spin-sensitive tunneling
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article Magnetic stability of holmium atoms on a platinum(111) surface has recently been reported, raising prospects for atomic-scale spintronics, however contradictory results have since emerged. Here, Steinbrecher et al. find evidence for an invisibility of the holmium spin to scanning tunnelling spectroscopy techniques which challenges recent results. Nature Communications doi: 10.1038/ncomms10454 Authors: M. Steinbrecher, A. […]
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