7-prenyloxi-6-methoxycoumarin from Polygala sabulosa A.W. Bennett Regulates p38 MAPK and NF-kB Pathways Inhibiting the Inflammation Induced by Carrageenan in the Mouse Model of Pleurisy
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In vitro effects of infrared A radiation on the synthesis of MMP-1, catalase, superoxide dismutase and GADD45 alpha protein
(Source: Inflammation and Allergy Drug Targets) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1PWtb0c via IFTTT
Analgesic and Anti-Inflammatory Properties of Arylnitroalkenes
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Design, Synthesis and In Vitro Release Studies of Co-Drugs for Rheumatoid Arthritis
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Cardiovascular Magnetic Resonance Imaging clarifies cardiac pathophysiology in early, asymptomatic diffuse systemic sclerosis
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Compounds Derived from Epigallocatechin-3-Gallate (EGCG) as a Novel Approach to the Prevention of Viral Infections
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Editorial: Challenge for the European Union: Immigrant and Refugee Health
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Gut Homing Molecule Regulation of the Pathogenesis and Treatment of Inflammatory Bowel Diseases
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Meet Our Editor:
This article is currently available as a free download on ingentaconnect (Source: Inflammation and Allergy Drug Targets) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mXicdO via IFTTT
Investigation of 5-HT2A gene expression in PBMCs of patients with allergic asthma
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Risk Factors for Pneumonia in Patients Undergoing Oral Cancer Surgery With Tracheotomy
Analysis of Risk Factors for Pneumonia in 482 Patients Undergoing Oral Cancer Surgery With Tracheotomy via Oral and Maxillofacial Surgery Publication date: February 2016 *Source:*Journal of Oral and Maxillofacial Surgery, Volume 74, Issue 2 Author(s): Li Li, Weijun Yuan, Shilei Zhang, Kewei Wang, Hong Ruan PurposeElective tracheostomy is a common procedure used in patients with oral cancer. However, secondary tracheotomy-associated pneumonia (TAP) is an important complication after surgery. This study investigated the risk factors related to postoperative TAP complications in patients w... περισσότερα »
Temporomandibular joint synovitis induced by occlusal alteration
Effect of p38 MAPK inhibitor on temporomandibular joint synovitis induced by occlusal alteration via Oral and Maxillofacial Surgery Publication date: Available online 7 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Linhong Jiang, Xuefen Lin, Ping Ji PurposeTo investigate the alteration in rats temporomandibular joint (TMJ) synovial membrane induced by increased occlusal vertical dimension (iOVD) and to find whether p38 mitogen activated protein kinase (MAPK) signaling cascade was involved.MethodsThirty-six rats were randomly divided into three groups: the c...περισσότερα »
Unilateral sagittal split mandibular ramus osteotomy
: indications and geometry via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 7 January 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Jacques Beukes, Johan P. Reyneke, Janalt Damstra Small mandibular asymmetries may be corrected by unilateral sagittal split ramus osteotomy (USSO). This study had two objectives: first to define the geometric changes in the mandibular condyle and the lower incisor teeth that result from the rotation of the major segment (n=26), and secondly to examine in a clinical study the temporomandibu...περισσότερα »
Sphenopalatine block in the management of trigeminal neuralgia
Sphenopalatine block in the management of trigeminal neuralgia: Trigeminal neuralgia is characterised by episodes of intense pain in the distribution of the trigeminal nerve that last for a few seconds to several minutes or even hours. It can be triggered by common activities such as eating, talking, and brushing teeth, and the attacks are said to feel like stabbing electric shocks, burning, pressing, crushing, exploding, or shooting pains that become unbearable.1
Anterograde excision of a sublingual gland
Anterograde excision of a sublingual gland: new surgical technique for the treatment of ranulas Wharton's duct is dissected in a retrograde direction from the orifice of the duct to the hilum of the submandibular gland when the gland is being excised conventionally. Here we describe an anterograde technique, in which Wharton's duct is dissected in an anterograde direction from the hilum of the submandibular gland to the orifice of the duct. This prospective clinical study included 50 consecutive patients with ranulas who had anterograde excision of the sublingual gland between May 2... περισσότερα »
Differences in Perilymphatic Space Enhancement and Adverse Inflammatory Reaction after Intratympanic Injection of Two Different Gadolinium Agents: A 9.4-Tesla Magnetic Resonance Imaging Study
Differences in Perilymphatic Space Enhancement and Adverse Inflammatory Reaction after Intratympanic Injection of Two Different Gadolinium Agents: A 9.4-Tesla Magnetic Resonance Imaging Study via Hearing Research Publication date: Available online 13 January 2016 *Source:*Hearing Research Author(s): Mina Park, Ho Sun Lee, Hyeonjin Kim, Seung Ha Oh, Jun Ho Lee, Myung-Whan Suh PurposeTo compare the inner ear enhancement after intratympanic injection of two widely used gadolinium (Gd) agents by 9.4 Tesla micro-magnetic resonance imaging (MRI) and to investigate the effects of Gd on the in... περισσότερα »
Longitudinal Multilevel Modeling of Facial Pain, Muscle Tension, and Stress
Longitudinal Multilevel Modeling of Facial Pain, Muscle Tension, and Stress: The role of masticatory muscle activation on pain in temporomandibular muscle and joint disorders (TMJD) is controversial. This single-group, prospective panel study examined the relationships among masticatory muscle tension, emotional distress, and TMJD pain in a sample of 7,023 observations obtained from 171 individuals using longitudinal multilevel modeling. Three main hypotheses were tested. The first posited that emotional distress and muscle tension directly influenced pain (hypothesis 1a: Distress... περισσότερα »
5’UTR +24T>C CR2 is not associated with Nasopharyngeal Carcinoma development
5’UTR +24T>C CR2 is not associated with Nasopharyngeal Carcinoma development in the North Region of Portugal: Abstract Objective We have analysed the association of the +24T>C polymorphism (rs3813946) in CR2, the cellular receptor for Epstein-Barr Virus (EBV), in the susceptibility for the development of Nasopharyngeal Carcinoma (NPC). Methods A retrospective case-control study was developed with peripheral blood samples from 111 individuals with NPC and 608 healthy individuals (controls) from the North region of Portugal. The genotyping analysis was performed by Allelic Discriminat... περισσότερα »
Internal jugular vein thrombosis after free flap vascular anastomosis
Longitudinal contraction venoplasty in prevention of internal jugular vein thrombosis after free flap vascular anastomosis via Oral and Maxillofacial Surgery Publication date: Available online 8 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Zhao-Jian Gong, Yan-rong Chen, Kai Wang, Sheng Zhang, Zhen-hu Ren, Han-Jiang Wu PurposeThe vascular anastomosis of free flap with the internal jugular vein stump is prone to thrombosis, thus resulting in flap compromise or failure. This paper aims to explore the method of longitudinal contraction venoplasty in prevention...περισσότερα »
Risk factors for free flap failure
Risk factors for free flap failure in 2,846 patients with head and neck cancer: a national database study in Japan via Oral and Maxillofacial Surgery Publication date: Available online 8 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Miho Ishimaru, Sachiko Ono, Sayaka Suzuki, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga PurposeThe risk factors for unfavorable outcome after microvascular free flap reconstruction in head and neck cancer are not fully understood.MethodsThis was a retrospective cohort study using data from the national inpatient database betw...περισσότερα »
Head and neck cancer treatment patterns and outcomes
Health insurance affects via Oral and Maxillofacial Surgery Publication date: Available online 8 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Gino Inverso, Brandon A. Mahal, Ayal A. Aizer, R. Bruce Donoff, Sung-Kiang Chuang PurposeThe purpose of this study is to examine the effect of insurance coverage on stage of presentation, treatment, and survival of head and neck cancer (HNC).Materials and MethodsA retrospective study was conducted utilizing the Surveillance, Epidemiology and End Results (SEER) program to identify patients diagnosed with HNC. The pri... περισσότερα »
Tongue Sensory Deficits with Neurosurgical Reconstruction
Recovery of Impaired Somatosensory Evoked Fields after Improvement of Tongue Sensory Deficits with Neurosurgical Reconstruction via Oral and Maxillofacial Surgery Publication date: Available online 8 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Hitoshi Maezawa, Itaru Tojyo, Kazuya Yoshida, Shigeyuki Fujita Somatosensory evoked fields (SEFs) induced by tongue stimulation can be useful as an objective parameter to assess sensory disturbances in the tongue. However, whether tongue SEFs can be useful as a clinical, objective follow-up assessment method of tongu... περισσότερα »
Precise Maxillary Reconstruction with Vascularized Fibular Graft Following Tumor Ablation
Virtual Surgical Planning in via Oral and Maxillofacial Surgery Publication date: Available online 9 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): You-yuan Wang, Song Fan, Han-qing Zhang, Zhao-yu Lin, Jian-tao Ye, Jin-song Li PurposeReconstruction of the maxillary and midfacial defect due to tumor ablation is challenging to conventional operation. The purpose of this study is to evaluate the precise three-dimensional position of the fibular flap in reconstruction of maxillary defect assisted by virtual surgical planning and to assess the postoperative outc... περισσότερα »
Adenoid Cystic Carcinoma Of Accessory Parotid Gland
: A Case Report via Oral and Maxillofacial Surgery [image: Mid-cheek swelling marked in the patient] [image: CT scan showing hypodense well-circumscribed mass located superficial to the ...] [image: Intraoperative figure showing the accessory parotid gland tumor anterior to the ...] [image: A: Histopathological picture of 20X magnification showing fairly well ...] *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Somdipto Das, Umanath K. Nayak, Rahul Buggavetti, Shobana Sekhar
Acute and chronic invasive fungal rhinosinusitis (IFRS) in adults
: our experience in diagnosis and management via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 9 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Fabio Pagella, Francesca De Bernardi, Daniela Dalla Gasperina, Alessandro Pusateri, Elina Matti, Irene Avato, Caterina Cavanna, Patrizia Zappasodi, Maurizio Bignami, Elena Bernardini, Paolo Antonio Grossi, Paolo Castelnuovo BackgroundThis paper describes our experience in the management of acute and chronic invasive fungal rhinosinusitis (IFRS) in adults.MethodsMed...περισσότερα »
Mylohyoid Flap in the Treatment of Bisphosphonate Related Osteonecrosis of the Jaws
The Role of via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 8 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Thomas Mücke, Steffen Koerdt, Maximilian Jung, David A. Mitchell, Klaus-Dietrich Wolff, Marco Rainer Kesting, Denys John Loeffelbein IntroductionSurgical treatment of Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ) combines excision of adequate damaged bone and watertight coverage by appropriate vascularised tissue. Local tissues are preferred when possible. This study compares local muc...περισσότερα »
Donor site morbidity of anterior iliac crest and calvarium bone grafts
: A comparative case-control study via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 8 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Karel Kuik, Thomas F. Putters, Jurjen Schortinghuis, Baucke van Minnen, Arjan Vissink, Gerry M. Raghoebar PurposeNotwithstanding its donor site morbidity, autogenous bone graft harvesting is still considered the gold standard for cases of extreme resorption of the alveolar ridge. The aim of this study was to assess donor site morbidity of calvarium and anterior iliac crest h... περισσότερα »
Immunophenotyped macrophages expressing CD163 with PDGF-B in gingival overgrowth
In vivo association of immunophenotyped macrophages expressing CD163 with PDGF-B in gingival overgrowth-induced by three different categories of medications via ScienceDirect Publication: Journal of Oral Biology and Craniofacial Research Publication date: Available online 9 January 2016 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Amina J. Almahrog, Lobna R.S. Radwan, Rehab R. El-Zehery, Mohamed I. Mourad, Mohammed E. Grawish AimsThis study was carried out to identify and outline the degree of relationship between immunophenotyped macrophages expressing CD163 a... περισσότερα »
Comparison of flowable bulk-fill and flowable resin-based composites: an in vitro analysis
Comparison of flowable bulk-fill and flowable resin-based composites: an in vitro analysis: Abstract ObjectivesFlowable bulk-fill resin bonded composites (RBCs) are supposed to show improved abrasion resistance and fracture toughness in comparison to flowable conventional RBCs. Materials and methodsSpecimens of eight flowable RBCs (5× flowable conventional, 3× flowable bulk-fill) were fabricated for testing relative fracture toughness (SENB), relative three-body wear, the Vickers hardness, glass transition Tg (differential scanning calorimetry; DSC) and filler mass fraction (th... περισσότερα »
Sera and salivary matrix metalloproteinases are elevated in patients with vesiculoerosive disease
: A pilot study via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 9 January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Yasmin H. Mair, Tania Jhamb, Michelle B. Visser, Alfredo Aguirre, Jill M. Kramer Oral vesiculoerosive diseases (VE), such as lichen planus and mucous membrane pemphigoid, are immune-mediated pathoses. Matrix metalloproteinases-2 and -9 (MMP-2 and -9) are elevated in oral lesional biopsies of patients with vesiculoerosive (VE) disease. However, the systemic levels and activi...περισσότερα »
Oral vesiculoerosive diseases (VE), such as lichen planus and mucous membrane pemphigoid, are immune-mediated pathoses
Sera and salivary matrix metalloproteinases are elevated in patients with vesiculoerosive disease: A pilot study via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 9 January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Yasmin H. Mair, Tania Jhamb, Michelle B. Visser, Alfredo Aguirre, Jill M. Kramer Oral vesiculoerosive diseases (VE), such as lichen planus and mucous membrane pemphigoid, are immune-mediated pathoses. Matrix metalloproteinases-2 and -9 (MMP-2 and -9) are elevated in oral lesional... περισσότερα »
Metastatic HPV-related head and neck squamous cell carcinoma to the lung and mediastinal lymph nodes in aspirated cytology material: A diagnostic pitfall
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Background Although HPV-related head and neck squamous cell carcinoma (HNSCC) has good prognosis, a small proportion of patients develop distant metastases and have worse outcomes. Such metastases can be particularly difficult to diagnose in the lung and mediastinum, where they show extensive morphologic overlap with primary pulmonary neoplasms. This case series discusses metastatic HPV-related HNSCC in lung and mediastinal fine needle aspiration (FNA) cytology. Methods The cytopathology archives were searched for lung and mediastinal FNA specimens of patients with HNSCC. Specim... περισσότερα »
Pulmonary nocardiosis in fine-needle aspiration cytology smears: Report of four cases
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Nocardia has been recognized as a significant opportunistic pathogen in organ transplant patients; however, it is an uncommon pathogen in immunocompetent patients. It may mimic other infectious diseases both clinically and radiologically. We report four cases of pulmonary nocardiosis in three immunocompromised and one immunocompetent patients on fine-needle aspiration cytology (FNAC). Two patients presented with lung consolidation while two had cavitatory lesions. FNAC smears showed inflammatory cells composed of polymorphs and histiocytes along with necrosis. Occasional epitheli... περισσότερα »
Laligam Sekhar, Richard G. Fessler: Atlas of neurosurgical techniques: brain, second edition, two volume set
from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1OZQARv via IFTTT
Comparison of the clinical and radiologic outcomes obtained with single- versus two-level anterior cervical decompression and fusion using stand-alone PEEK cages filled with allograft
Abstract Background Although anterior cervical decompression and fusion with a stand-alone cage (ACDF-SAC) is accepted as a suitable procedure, the outcomes of the multi-level procedure remain controversial. The aim of this study is to compare the clinical and radiologic outcomes achieved with single versus two-level ACDF-SAC along with identification of the factors that contribute to loss in mean disc height (MDH) and change in cervical lordotic angle (CLA). Methods A total of 109 consecutive patients who underwent ACDF-SAC for degenerative spondylosis were reviewed. Patients we... περισσότερα »
Effect of ozone to remineralize initial enamel caries: in situ study
Abstract Objectives Effect of ozonated water in remineralizing artificially created initial enamel caries was investigated using laser fluorescence and polarized light microscopy in an in situ study. Materials and methods Teeth specimens (buccal sections) were immersed in 5-ml solution of 2 mM CaCl2, 2 mM NaH2P04, and 50 mM CH3COOH at pH of 4.55 for 5 h in an incubator at 37° to create subsurface demineralization. After which, they were randomly allocated into one of the following remineralization regimens: ozone (ozonated water 0.1 mg/l and 10 % nano-hydroxyapatite paste, Aclaim...περισσότερα »
Apical debris extrusion associated with oval shaped canals: a comparative study of WaveOne vs Self-Adjusting File
Abstract Objectives The aim was to evaluate ex vivo apical debris extrusion associated with WaveOne and Self-Adjusting File instruments when used in oval canals. Methods Twenty-four extracted human mandibular premolars with oval-shaped canals were assigned in two equal groups. Following coronal cavity preparation, a glide path was created. Group A was subjected to canal preparation using a WaveOne primary file, which was used along with syringe and needle irrigation and 10 mL of 2.4 % NaOCl solution, followed by flushing with 10 mL of 17 % EDTA solution, activation with EndoActiva...περισσότερα »
In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis
Abstract Objectives The aim of the present study was to assess the antimicrobial activity of a sodium hypochlorite formulation including its components against bacteria associated with periodontal disease. Materials and methods Sodium hypochlorite formulation (NaOCl gel), its components sodium hypochlorite (NaOCl), and the activating vehicle were compared with 0.1 % chlorhexidine digluconate (CHX) solution. The antimicrobial activity was proven by determination of minimal inhibitory concentrations (MIC), minimal bactericidal concentrations, and killing assays. Furthermore, the inf...περισσότερα »
Mastermind-like 2 (MAML2) gene rearrangement detection by fluorescent in-situ hybridization (FISH) in mucoepidermoid carcinoma of the salivary glands
Diagnostic and prognostic utility of via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 9 January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Peter P. Luk, James Wykes, Christina I. Selinger, Rafael Ekmejian, Jessica Tay, Kan Gao, Timothy J. Eviston, Trina Lum, Sandra A. O’Toole, Jonathan R. Clark, Ruta Gupta ObjectiveMucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy, with a proportion harboring MAML2 rearrangement. This study evaluates the diagnostic and prognostic ...περισσότερα »
Effects of oral clonidine premedication on hemodynamic status in bimaxillary orthognathic surgery: A double-blind randomized clinical trial
Effects of oral clonidine premedication on hemodynamic status in bimaxillary orthognathic surgery: A double-blind randomized clinical trial: Controlled hypotension during a surgical procedure is a way to decrease blood pressure and subsequently to improve the field of operation. Clonidine is an antihypertensive agent used for induced hypotension. Correction of maxillomandibular discrepancies may necessitate performing osteotomy on both jaws in many cases. Bimaxillary orthognathic surgery is a procedure that is associated with significant blood loss.
Modified protocol including topical minocycline in orabase to manage medication-related osteonecrosis of the jaw cases
Modified protocol including topical minocycline in orabase to manage medication-related osteonecrosis of the jaw cases: Objective Management of medication-related osteone-crosis of the jaw (MRONJ) with active infection can be a serious challenge for clinicians. Based on Association of Oral and Maxillofacial Surgeons (AAOMS) recommendations, we have tested a modified treatment protocol using topical minocycline. Study Design Five patients diagnosed with stage II or III MRONJ lesions were willing to consent to our protocol. In addition to conventional treatment as suggested by the AAO...περισσότερα »
Oral lichen planus
Cost of illness of oral lichen planus in a UK population – a pilot study: Objective To assess the economic burden of oral lichen planus (OLP) from the perspective of the healthcare provider in a UK population. Methods This prevalence-based cost-of-illness analysis was carried out via a cross-sectional study conducted in the Oral Medicine Unit of the Eastman Dental Hospital. This study was conducted in three phases – phase 1 involved framing of the cost-of-illness analysis, development of the cost inventory and design of the patient questionnaire for ease of data collection. Data col... περισσότερα »
Invadopodia proteins, cortactin, N-WASP and WIP differentially promote local invasiveness in ameloblastoma
Invadopodia proteins, cortactin, N-WASP and WIP differentially promote local invasiveness in ameloblastoma: Background Cell migration and invasion through interstitial tissues are dependent upon several specialized characteristics of the migratory cell notably generation of proteolytic membranous protrusions or invadopodia. Ameloblastoma is a benign odontogenic epithelial neoplasm with a locally infiltrative behaviour. Cortactin and MMT1-MMP are two invadopodia proteins implicated in its local invasiveness. Other invadopodia regulators, namely N-WASP, WIP and Src kinase remain uncl...περισσότερα »
Patterns and surgical significance of facial nerve branching within the parotid gland
Patterns and surgical significance of facial nerve branching within the parotid gland in 43 cases: Abstract PurposeDifferent patterns of facial nerve branching within the parotid gland were detected, and these anatomical variations may affect the treatment approaches and outcomes of surgery. The aim of this study was to identify the patterns of facial nerve branching with the parotid gland and their importance in surgical procedures. Materials and methodsA total of 43 patients undergoing surgical treatments of parotid lesions were included in this study. Each patient’s demograp... περισσότερα »
Middle ear findings and need for ventilation tubes among pediatric cleft lip and palate patients
in northern Finland via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 11 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Ville Lehtonen, Riitta H. Lithovius, Timo J. Autio, George K. Sándor, Leena P. Ylikontiola, Virpi Harila, Paula Pesonen, Sari Koskinen, Vuokko Anttonen PurposeMiddle ear problems are common in cleft patients. This study aimed to determine the need for ventilation tubes (VTs) and complications such as tympanic perforation and cholesteatoma.Material and MethodsData of 156 children with cl... περισσότερα »
The relationship between EMT, CD44high/EGFRlow phenotype, and treatment response in head and neck cancer cell lines
The relationship between EMT, CD44high/EGFRlow phenotype, and treatment response in head and neck cancer cell lines: Background Head and neck squamous cell carcinoma (HNSCC) tumors are often therapy resistant and may originate from cancer stem cells or tumor cells with an epithelial-to-mesenchymal transition (EMT) phenotype. The aim of this study was to characterize HNSCC cell lines with regard to EMT profile and to investigate the influence of EMT on the response to treatment. Methods mRNA expression of the EMT-associated genes *CDH1* (E-cadherin), *CDH2* (N-cadherin), *FOXC2*,* TW... περισσότερα »
Melatonin's protective effect on the salivary gland against ionized radiation damage in rats
Melatonin's protective effect on the salivary gland against ionized radiation damage in rats: Objectives The aim of this study was to examine the effects of melatonin on ionized radiation-induced salivary gland damage using an experimental model. Materials and Methods Thirty-two rats were randomized into four groups: (i) the control group (C, *n* = 8) that received intraperitoneal (i.p.) 0.9% NaCl; (ii) the melatonin group (M, *n* = 8) that received i.p. 5 mg/kg melatonin; (iii) the radiotherapy group (RT,* n* = 8) that underwent irradiation; (iv) the melatonin plus radiotherapy gro... περισσότερα »
Interaction of stromal and microvascular components in keratocystic odontogenic tumors
Interaction of stromal and microvascular components in keratocystic odontogenic tumors: Objective Little is known about the interaction of stromal components in odontogenic tumors. Thus, the aim of this study was to investigate mast cells (MCs), myofibroblasts, macrophages, and their possible association with angiogenesis and lymphangiogenesis in keratocystic odontogenic tumors (KCOTs). Material and Methods Thirty cases of KCOTs were included and analyzed by immunohistochemistry for mast cell tryptase, α-SMA, CD34, CD163, and D240. For comparative purpose, 15 radicular cysts (CRs) ... περισσότερα »
Two-week rule in head and neck cancer
Two-week rule in head and neck cancer 2000-14: a systematic review The fast-track system in the UK for patients with suspected cancer – the two-week rule - states that if cancer is suspected there should be a maximum of 14 days between referral from primary care and consultation with a specialist. This approach is valued by patients, ensures a universal standard of diagnosis, and speeds up the overall management of cancer. However, some say that the rule has had little or no effect on survival, results in a diagnosis of cancer in only a small proportion of patients referred, and is ... περισσότερα »
Columella-stabilising suture: a simple adjunct to nasal septal surgery
Columella-stabilising suture: a simple adjunct to nasal septal surgery: Septal deviation, whatever the cause, may disturb the form and function of the nose, and can range from a mild aesthetic problem at the caudal septal end to a more severe and complex deformity resulting in collapse of the tip, severe deviation, and nasal obstruction.
Three-dimensional maxillary and mandibular regional superimposition using cone beam computed tomography: a validation study
Three-dimensional maxillary and mandibular regional superimposition using cone beam computed tomography: a validation study: This study aimed to validate a novel method for fast regional superimposition of cone beam computed tomography (CBCT) scans. The method can be used with smaller field of view scans, thereby allowing for a lower radiation dose. This retrospective study used two dry skulls and secondary data from 15 patients who had more than one scan taken using the same machine. Two observers tested two types of regional voxel-based superimposition: maxillary and mandibular. T...περισσότερα »
Trigeminocardiac reflex and haemodynamic changes during Le Fort I osteotomy
Trigeminocardiac reflex and haemodynamic changes during Le Fort I osteotomy by M.T. Kiani, G. Tajik, M. Ajami, H. Fazli, M.J. Kharazifard, A. Mesgarzadeh via Oral & Maxillofacial Surgery The Le Fort I osteotomy is performed under general anaesthesia and specific haemodynamic conditions, i.e. hypotensive general anaesthesia. This study assessed the incidence of the trigeminocardiac reflex (TCR) during the different stages of the Le Fort I osteotomy. Forty-seven patients requiring a Le Fort I osteotomy were included. General anaesthesia was induced. In terms of haemodynamic changes, eac... περισσότερα »
Calcifying ghost cell odontogenic tumor (CGCOT) with predominance of clear cells
: a case report with important diagnostic considerations via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: February 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 121, Issue 2 Author(s): Aadithya B. Urs, Jeyaseelan Augustine, Hanspal Singh, Kirti Kureel, Sujata Mohanty, Shalini Gupta An 18-year-old female reported painful swelling in the left maxillary region 4 months after the extraction of tooth #15. Because incisional biopsy suggested ameloblastoma with clear-cell changes, segmental resection was performed. The...περισσότερα »
Sodium-hypochlorite gel on bacteria associated with periodontitis
In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis: Abstract ObjectivesThe aim of the present study was to assess the antimicrobial activity of a sodium hypochlorite formulation including its components against bacteria associated with periodontal disease. Materials and methodsSodium hypochlorite formulation (NaOCl gel), its components sodium hypochlorite (NaOCl), and the activating vehicle were compared with 0.1 % chlorhexidine digluconate (CHX) solution. The antimicrobial activity was proven by determination of minimal inhibitory concentra... περισσότερα »
Somatic arousal and sleepiness/fatigue among patients with sleep-disordered breathing
Somatic arousal and sleepiness/fatigue among patients with sleep-disordered breathing: Abstract ObjectivesIn a large clinical sample, we tested the hypothesis that levels of sleepiness and fatigue among upper airway resistance syndrome (UARS) patients are correlated with levels of somatic arousal (SA; reflecting the sympathetic nervous system component of the stress response). We also tested the correlations of post-treatment change in these three parameters, and we extended the investigation to obstructive sleep apnea/hypopnea (OSA/H) patients. MethodsFrom 5 years of patient d... περισσότερα »
Five-Minute Awake Snoring Test for Determining CPAP Pressures (Five-Minute CPAP Test): A Pilot Study
Five-Minute Awake Snoring Test for Determining CPAP Pressures (Five-Minute CPAP Test): A Pilot Study: Objective. To develop a quick, simple, bedside test for determining continuous positive airway pressures (CPAP) for obstructive sleep apnea (OSA) patients. Study Design. Prospective case series at a tertiary medical center. Methods. The Five-Minute Awake Snoring Test for Determining CPAP (Five-Minute CPAP Test) was developed and tested. Patients wear a soft-gel nasal triangle mask while holding a tongue depressor with the wide section (1.75 cm) between the teeth. Fixed pressure nasa...περισσότερα »
Oral appliance in sleep apnea treatment
Oral appliance in sleep apnea treatment: respiratory and clinical effects and long-term adherence: Abstract PurposeThere is an increasing tendency to use oral appliance (OA) as an alternative treatment for sleep apnea. Here we report the long-term adherence and clinical effects of OA therapy. MethodsAll sleep apnea patients treated at the Department of Dentistry between the years 2006 and 2013 (*n* = 1208) were reviewed. A questionnaire about OA adherence, asthma symptoms (Asthma Control Test™, ACT), and general health was sent to all patients who continued OA therapy after the...περισσότερα »
A telehealth program for CPAP adherence reduces labor and yields similar adherence and efficacy when compared to standard of care
A telehealth program for CPAP adherence reduces labor and yields similar adherence and efficacy when compared to standard of care: Abstract PurposeThis study evaluated the effectiveness and coaching labor requirements of a web-based automated telehealth (TH) messaging program compared with standard of care (SOC) in newly diagnosed patients with obstructive sleep apnea (OSA). MethodsIn this non-blinded, multicenter, prospective study, all patients were started on continuous positive airway pressure (CPAP) with heated humidification and a wireless modem. They all received standar...περισσότερα »
Cervical Lymphadenopathies in Children
: A Prospective Clinical Cohort Study via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 12 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Sedar Bozlak, Muhammet Ali Varkal, Ismail Yildiz, Sadik Toprak, Serap Karaman, Oguz Bülent Erol, Ensar Yekeler, Ayşegul Unuvar, Ayse Kilic, Fatma Oguz, Emin Unuvar AimCervical lymphadenopathy (LAP) is a common sign and may raise fears about serious illnesses. The aim of our study was to evaluate the patients with cervical LAPs in a general pediatrics clinic setting, a...περισσότερα »
Role of apoptosis in common variable immunodeficiency and selective immunoglobulin A deficiency
Publication date: March 2016 *Source:*Molecular Immunology, Volume 71 Author(s): Reza Yazdani, Maryam Fatholahi, Mazdak Ganjalikhani-Hakemi, Hassan Abolhassani, Gholamreza Azizi, Kabir Magaji Hamid, Nima Rezaei, Asghar Aghamohammadi Common variable immunodeficiency (CVID) and selective IgA deficiency (SIgAD) are the most common primary immunodeficiencies in human. Both diseases share clinical manifestation and molecular defects. Increased apoptosis may be one of the mechanisms involved in the pathogenesis of CVID and SIgAD. Elevated apoptosis in this disorder leads to defective long... περισσότερα »
Tracheal Fibroepithelial Polyp
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The Effect of General Anesthesia Versus Intravenous Sedation on Diagnostic Yield and Success in Electromagnetic Navigation Bronchoscopy
[image: image]Background: Navigational bronchoscopy is utilized to guide biopsies of peripheral lung nodules and place fiducial markers for treatment of limited stage lung cancer with stereotactic body radiotherapy. The type of sedation used for this procedure remains controversial. We performed a retrospective chart review to evaluate the differences of diagnostic yield and overall success of the procedure based on anesthesia type. Methods: Electromagnetic navigational bronchoscopy was performed using the superDimension software system. Once the targeted lesion was within reach, mu... περισσότερα »
Endobronchial Ultrasound-guided Transbronchial Needle Aspiration: Indian Perspective
No abstract available from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1OhypmG via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1J2eYQ6 via IFTTT
Construct Validity of the Simbionix Bronch Mentor Simulator for Essential Bronchoscopic Skills
[image: image]Background: Although simulation-based bronchoscopy has been shown to be an effective training modality, formal assessment should still be performed as new technology emerges. We sought to validate a simulator in essential bronchoscopic tasks, and survey perceptions of bronchoscopists on simulation. Methods: A cohort study at 2 medical centers used 3 groups to assess construct validity of the Simbionix Bronchoscopy Simulator: 7 first-year fellows with 1000 bronchoscopies each (expert). Participants were tested in 4 tasks (1: scope manipulation, 2: guided anatomic naviga...περισσότερα »
Lipoid Pneumonia as a Complication of Lorenzo’s Oil Therapy in a Patient With Adrenoleukodystrophy
[image: image]Lipoid pneumonia (LP) is a rare exogenous condition caused by inhalation or aspiration of lipid material into the lungs. It is often associated with the therapeutic use of different types of oil, and the diagnosis is based on the demonstration of lipid-laden macrophages in bronchoalveolar lavage fluid. We reported the case of a 39-year-old male with X-linked adrenoleukodystrophy who developed LP secondary to the use of Lorenzo's oil. To our knowledge, the association between the use of Lorenzo's oil and LP has never been reported in literature. from #MedicinebyAlexandr... περισσότερα »
A Remedy for Hoarseness in a Patient With Granulomatosis With Polyangiitis
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A Young Woman With Recurrent Lower Respiratory Tract Infection
[image: image]Tracheobronchomegaly is a rare congenital abnormality with marked widening of the trachea and major bronchi, in most cases associated with chronic recurrent respiratory tract infection. We present this rare syndrome in a young woman who presented with recurrent respiratory tract infection. She was found to have tracheobronchomegaly on flexible bronchoscopy, which was confirmed with high-resolution computed tomography findings. from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1ShGmfy via IFTTT from #Med Blogs by Alexandros G.Sfakianakis ... περισσότερα »
Extracorporeal Membrane Oxygenation to Support Whole-lung Lavage in Pulmonary Alveolar Proteinosis: Salvage of the Drowned Lungs
[image: image]Pulmonary alveolar proteinosis is a rare lung disease characterized by accumulation of lipoproteinaceous material within the alveoli. Therapeutic whole-lung lavage (WLL) under general anesthesia is the standard treatment in patients with progressive symptomatic disease. Severe hypoxemic respiratory failure is uncommon, yet when present poses a technical challenge to performing WLL without further compromising respiratory status. Rarely, hyperbaric chamber or extracorporeal membrane oxygenation (ECMO) has been utilized to perform WLL to manage severe hypoxemia, with ven...περισσότερα »
Multiple Endobronchial Polyps
[image: image]Multiple endobronchial polyps are a rare finding. We describe a case of multiple benign endobronchial polyps in a 60-year-old woman who presented with a chronic cough and occasional hemoptysis. Chest computed tomography revealed bilateral basal cylindrical bronchiectasis, with filling defects in both main bronchi. Bronchoscopy revealed the presence of polyps in the distal trachea, both main bronchi, and in the lobar and segmental bronchi of all lobes of both lungs, with lesions from 2 to 10 mm in diameter. Larger lesions were treated with argon plasma coagulation. Hist...περισσότερα »
James E. Peck, Pseudohypacusis: False and Exaggerated Hearing Loss. ISBN-13 Number: 978-1-59756-397-0, ISBN-10 Number: 1-59756-397-8.
Publication date: February 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 81 Author(s): Ross J. Roeser from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1RCkxaO via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OhywPb via IFTTT
Blood Genome-Wide Transcriptional Profiles of HER2 Negative Breast Cancers Patients
Tumors act systemically to sustain cancer progression, affecting the physiological processes in the host and triggering responses in the blood circulating cells. In this study, we explored blood transcriptional patterns of patients with two subtypes of HER2 negative breast cancers, with different prognosis and therapeutic outcome. Peripheral blood samples from seven healthy female donors and 29 women with breast cancer including 14 triple-negative breast cancers and 15 hormone-dependent breast cancers were evaluated by microarray. We also evaluated the stroma in primary tumors. Tr... περισσότερα »
Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread
Abstract Spread of head and neck cancer along the cranial nerves is often a lethal complication of this tumour. Current treatment options include surgical resection and/or radiotherapy, but recurrence is a frequent event suggesting that our understanding of this tumour and its microenvironment is incomplete. In this study, we have analysed the nature of the perineural tumour microenvironment by immunohistochemistry with particular focus on immune cells and molecules, which might impair anti-tumour immunity. Moderate to marked lymphocyte infiltrates were present in 58.8 % of the pat...περισσότερα »
Serum elevation of B lymphocyte stimulator does not increase regulatory B cells in glioblastoma patients undergoing immunotherapy
Abstract Regulatory B cells that secrete IL-10 (IL-10+ Bregs) represent a suppressive subset of the B cell compartment with prominent anti-inflammatory capacity, capable of suppressing cellular and humoral responses to cancer and vaccines. B lymphocyte stimulator (BLyS) is a key regulatory molecule in IL-10+ Breg biology with tightly controlled serum levels. However, BLyS levels can be drastically altered upon chemotherapeutic intervention. We have previously shown that serum BLyS levels are elevated, and directly associated, with increased antigen-specific antibody titers in patie... περισσότερα »
8th Annual Canadian Cancer Immunotherapy Consortium (CCIC) Symposium 2015—May 20–22, Vancouver, Canada
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Poly(I:C) potentiates Bacillus Calmette–Guérin immunotherapy for bladder cancer
Abstract Non-specific immunotherapy consisting of intravesical instillation of Bacillus Calmette–Guérin (BCG) is currently the best available treatment to prevent non-muscle-invasive bladder tumor recurrence and progression. This treatment however is suboptimal, and more effective immunotherapeutic approaches are needed. Toll-like receptors (TLRs) play a major role in the activation of the immune system in response to pathogens and danger signals but also in anti-tumor responses. We previously showed that human urothelial cells express functional TLRs and respond to TLR2 and TLR3 a...περισσότερα »
Acknowledgement
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IL-6 down-regulates HLA class II expression and IL-12 production of human dendritic cells to impair activation of antigen-specific CD4 + T cells
Abstract Immunosuppression in tumor microenvironments critically affects the success of cancer immunotherapy. Here, we focused on the role of interleukin (IL)-6/signal transducer and activator of transcription (STAT3) signaling cascade in immune regulation by human dendritic cells (DCs). IL-6-conditioned monocyte-derived DCs (MoDCs) impaired the presenting ability of cancer-related antigens. Interferon (IFN)-γ production attenuated by CD4+ T cells co-cultured with IL-6-conditioned MoDCs corresponded with decreased DC IL-12p70 production. Human leukocyte antigen (HLA)-DR and CD86 ex... περισσότερα »
Sugar Consumption and Changes in Dental Caries from Childhood to Adolescence
There are no prospective studies investigating the effects of sugar-related feeding practices on changes in dental caries from early childhood to young adulthood. The aim of this study was to assess whether sugar-related feeding practices affect dental caries between the ages of 6 and 18 y. This birth cohort study was initiated in 1993 in Pelotas, Brazil. There were 3 dental clinical assessments; at ages 6 y (*n* = 359), 12 y (*n* = 339), and 18 y (*n* = 307). Sugar-related feeding practices were assessed at ages 4, 15, and 18 y. Covariates included sex and life course variables, s... περισσότερα »
Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals
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Animal Models for the Study of Subarachnoid Hemorrhage: Are We Moving Towards Increased Standardization?
from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1nhNLPe via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PWkIKo via IFTTT
The contribution of ultrasonic vocalizations to mouse courtship
[image: S09594388.gif] Publication date: June 2016 *Source:*Current Opinion in Neurobiology, Volume 38 Author(s): SE Roian Egnor, Kelly M Seagraves Vocalizations transmit information to social partners, and mice use these signals to exchange information during courtship. Ultrasonic vocalizations from adult males are tightly associated with their interactions with females, and vary as a function of male quality. Work in the last decade has established that the spectrotemporal features of male vocalizations are not learned, but that female attention toward specific vocal features is m... περισσότερα »
Reversal of rocuronium‐induced neuromuscular blockade by sugammadex allows for optimization of neural monito ring of the recurrent laryngeal nerve
ConclusionsBoth porcine modeling and clinical human application demonstrated that sugammadex 2 mg/kg allows effective and rapid restoration of neuromuscular function suppressed by rocuronium. Implementation of this enhanced NMB recovery protocol assures optimal conditions for tracheal intubation as well as IONM in thyroid surgery. Level of EvidenceNA Laryngoscope, 2016 (Source: The Laryngoscope) from ORL-Medicine by Sfakianakis via alwin on Inoreader http://ift.tt/1ZspyqC via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.... περισσότερα »
Neck abscess: An unusual clinical presentation of immunoglobulin G4 related disease
(Source: The Laryngoscope) from ORL-Medicine by Sfakianakis via alwin on Inoreader http://ift.tt/1Zspyal via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1nhNJqI via IFTTT
Productivity outcomes following endoscopic sinus surgery for recurrent acute rhinosinusitis
ConclusionsRARS patients report baseline productivity losses and disease‐specific QOL impairment to levels that parallel those with CRSsNP. Patients with RARS report improvement in QOL following ESS in all disease‐specific QOL measures and in several medication measures. Productivity losses and postoperative improvements are similar between patients with RARS and CRSsNP. Level of Evidence3b Laryngoscope, 2015 (Source: The Laryngoscope) from ORL-Medicine by Sfakianakis via alwin on Inoreader http://ift.tt/1Zspyad via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandr... περισσότερα »
Case‐control study evaluating competing risk factors for angioedema in a high‐risk population
ConclusionRace–ethnicity acts as an effect modifier for particular angioedema risk factors. The two strongest risk factors, ACE‐I use and black race, were not synergistic. Level of Evidence3b. Laryngoscope, 2016 (Source: The Laryngoscope) from ORL-Medicine by Sfakianakis via alwin on Inoreader http://ift.tt/1PWbU7v via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1l5agVP via IFTTT
Airway foreign body removal by balloon catheter via flexible bronchoscope in children
The efficacy and safety of airway foreign body removal by balloon catheter via flexible bronchoscope in children-A retrospective analysis via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 13 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Xiaobo Chen, Yu Chen, Changhao Zhong, Yunxiang Zeng, Weizhan Luo, Shiyue Li ObjectivesTo investigate the efficacy and safety of the airway foreign body removal by balloon catheter via flexible bronchoscope in childrenMethodsRetrospective analysis was performed of 26 cas...περισσότερα »
Paediatric Day-Stay Laryngeal Surgery for Recurrent Respiratory Papillomatosis
Safety of via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 13 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Gruber Maayan, Mills Nicola, Blair Dora, Graeme Van Der Meer, Mahadevan Murali ObjectiveSafety assessment of day-stay laryngeal surgery in a cohort of children with Recurrent Respiratory Papillomatosis (RRP). Recurrent Respiratory Papillomatosis is a chronic debilitating disease which usually requires multiple recurrent interventions under general anaesthesia. Day-stay surgery is an attractive... περισσότερα »
Sudden ocular ptosis
Sudden ocular ptosis via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 12 January 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): J. Carvalho, S. Cahen-Riehm, C. Debry, A. Dupret-Bories [image: a: CT of the facial bones, coronal section; b: MRI of the facial bones, coronal ...]
Predictors of disease complications and treatment outcome among patients with chronic suppurative otitis media
Predictors of disease complications and treatment outcome among patients with chronic suppurative otitis media attending a tertiary hospital, Mwanza Tanzania: Abstract BackgroundChronic suppurative otitis media (CSOM) is a major health problem in developing countries causing hearing loss and life threatening complications. Early and effective treatment based on the knowledge of causative micro-organisms and predictors of outcome are crucial in preventing these associated complications. This study was conducted to determine the predictors of CSOM complications, treatment outcome an...περισσότερα »
Audiological comparison between two different clips prostheses in stapes surgery.
Audiological comparison between two different clips prostheses in stapes surgery.: *Audiological comparison between two different clips prostheses in stapes surgery.* Rev Laryngol Otol Rhinol (Bord). 2015;136(1):33-6 Authors: Potena M, Portmann D, Guindi S Abstract OBJECTIVES: To compare audiometric results and complications of stapes surgery with two different types of piston prosthesis, the Portmann Clip Piston (Medtronic) (PCP) and the Soft Clip Piston (Kurz) (SCP). MATERIAL AND METHODS: Study conducted on 64 patients who underwent primary stapedotomy from 2008 to 2011. We ma... περισσότερα »
Congenital Cytomegalovirus.
Congenital Cytomegalovirus.: *Congenital Cytomegalovirus.* Adv Neonatal Care. 2016 Jan 8; Authors: Mestas E Abstract BACKGROUND: Congenital cytomegalovirus (CMV) is the leading viral intrauterine infection in the United States. It causes more developmental delays and long-term sequelae than Down syndrome (trisomy 21), neural tube defects, or fetal alcohol syndrome combined. Yet, this virus, a member of the herpes virus family, is not well known to the public and its prevention is typically not discussed in obstetric offices. Although many infants with congenital CMV are asymptom... περισσότερα »
Postural control in women with multiple sclerosis
Multiscale entropy identifies differences in complexity in postural control in women with multiple sclerosis via Gait & Posture Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Michael A. Busa, Stephanie L. Jones, Joseph Hamill, Richard E.A. van Emmerik Loss of postural center-of-pressure complexity (COP complexity) has been associated with reduced adaptability that accompanies disease and aging. The aim of this study was to identify if COP complexity is reduced: (1) in those with Multiple Sclerosis (MS) compared to controls; (2) when vision is limited compar...περισσότερα »
A multimodal spectral approach to characterize rhythm in natural speech
A multimodal spectral approach to characterize rhythm in natural speech: Human utterances demonstrate temporal patterning, also referred to as rhythm. While simple oromotor behaviors (e.g., chewing) feature a salient periodical structure, conversational speech displays a time-varying quasi-rhythmic pattern. Quantification of periodicity in speech is challenging. Unimodal spectral approaches have highlighted rhythmic aspects of speech. However, speech is a complex multimodal phenomenon that arises from the interplay of articulatory, respiratory, and vocal systems. The present study ... περισσότερα »
Influence of fat on liver T1 measurements using modified Look–Locker inversion recovery (MOLLI) methods at 3T
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Purpose To characterize the effect of fat on modified Look–Locker inversion recovery (MOLLI) T1 maps of the liver. The balanced steady-state free precession (bSSFP) sequence causes water and fat signals to have opposite phase when repetition time (TR) = 2.3 msec at 3T. In voxels that contain both fat and water, the MOLLI T1 measurement […]
Vegetarian diet: How to get the best nutrition
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1FCN59K via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Hyperglycemic Choreaballism: A Rare Syndrome of Acute Dyskinesias in the Adult Population
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Publication date: Available online 12 January 2016 Source:Basal Ganglia Author(s): Noureldin Abdelhamid, Salman Farooq, Shahzad Mehr, David Lichter Hemiballismus-hemichorea is a rare complication of nonketotic hyperglycemia. Neuroimaging in patients with this syndrome show characteristic findings with hyperintensity (spelling corrected) in basal ganglia. We present case of a 65year old female showing classic clinical and radiographic […]
Role of apoptosis in common variable immunodeficiency and selective immunoglobulin A deficiency
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Publication date: March 2016 Source:Molecular Immunology, Volume 71 Author(s): Reza Yazdani, Maryam Fatholahi, Mazdak Ganjalikhani-Hakemi, Hassan Abolhassani, Gholamreza Azizi, Kabir Magaji Hamid, Nima Rezaei, Asghar Aghamohammadi Common variable immunodeficiency (CVID) and selective IgA deficiency (SIgAD) are the most common primary immunodeficiencies in human. Both diseases share clinical manifestation and molecular defects. Increased apoptosis may be […]
FabAV antivenin use after copperhead snakebite: clinically indicated or knee-jerk reaction?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Abstract Background Crotalidae Polyvalent Immune Fab (Ovine) (FabAV) antivenin is commonly recommended after pit viper snakebites. Because copperhead envenomations are usually self-limited, some physicians are reluctant to use this costly treatment routinely, while others follow a more liberal approach. We hypothesized that, in practice, only patients with evidence of significant (moderate or severe) copperhead envenomation […]
Management of Intrapleural Sepsis with Once Daily Use of Tissue Plasminogen Activator and Deoxyribonuclease
Management of Intrapleural Sepsis with Once Daily Use of Tissue Plasminogen Activator and Deoxyribonuclease: *Background:* Pleural infection remains a significant cause of morbidity, mortality, prolonged hospital stay, and increased healthcare costs, despite advances in therapy. Twice daily intrapleural tissue plasminogen activator (tPA)/deoxyribonuclease (DNase) initiated at the time of diagnosis has been shown to significantly improve radiological outcomes and decrease the need for surgery. *Objectives:* To analyze our experience with once daily tPA/DNase for intrapleural sepsis. ... περισσότερα »
Antibiotics, Vol. 5, Pages 4: Microarray Evaluation of Antimicrobial Resistance and Virulence of Escherichia coli Isolates from Portuguese Poultry
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
The presence of antimicrobial resistance and virulence factors of 174 Escherichia coli strains isolated from healthy Portuguese Gallus gallus was evaluated. Resistance profiles were determined against 33 antimicrobials by microbroth dilution. Resistance was prevalent for tetracycline (70%) and ampicillin (63%). Extended-spectrum beta-lactamase (ESBL) phenotype was observed in 18% of the isolates. Multidrug resistance was found […]
Injectable insulin-lysozyme-loaded nanogels with enzymatically-controlled degradation and release for basal insulin treatment: In vitro characterization and in vivo observation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Publication date: 28 February 2016 Source:Journal of Controlled Release, Volume 224 Author(s): Hao-Syun Chou, Mikael Larsson, Meng-Hsuan Hsiao, Yi-Chieh Chen, Magnus Röding, Magnus Nydén, Dean-Mo Liu Diabetes is a common global disease that causes immense suffering for individuals and huge costs for the health care system. To minimize complications such as organ degeneration, diabetic patients […]
Applications of cyclodextrins in medical textiles — review
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Publication date: Available online 12 January 2016 Source:Journal of Controlled Release Author(s): Cezar-Doru Radu, Oana Parteni, Lacramioara Ochiuz This paper presents data on the general properties and complexing ability of cyclodextrins and assessment methods (phase solubility, DSC tests and X-ray diffraction, FTIR spectra, analytical method). It focuses on the formation of drug deposits on the […]
Adeno-associated virus (AAV) vectors in cancer gene therapy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Publication date: Available online 12 January 2016 Source:Journal of Controlled Release Author(s): Jorge L. Santiago-Ortiz, David V. Schaffer Gene delivery vectors based on adeno-associated virus (AAV) have been utilized in a large number of gene therapy clinical trials, which have demonstrated their strong safety profile and increasingly their therapeutic efficacy for treating monogenic diseases. For […]
IJMS, Vol. 17, Pages 93: miRNAs Regulation and Its Role as Biomarkers in Endometriosis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
MicroRNAs (miRNAs) are small non-coding RNAs (18–22 nt) that function as modulators of gene expression. Since their discovery in 1993 in C. elegans, our knowledge about their biogenesis, function, and mechanism of action has increased enormously, especially in recent years, with the development of deep-sequencing technologies. New biogenesis pathways and sources of miRNAs are changing […]
IJMS, Vol. 17, Pages 98: Optimizing a Male Reproductive Aging Mouse Model by d-Galactose Injection
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
The d-galactose (d-gal)-injected animal model, which is typically established by administering consecutive subcutaneous d-gal injections to animals for approximately six or eight weeks, has been frequently used for aging research. In addition, this animal model has been demonstrated to accelerate aging in the brain, kidneys, liver and blood cells. However, studies on aging in male […]
IJMS, Vol. 17, Pages 96: Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Prolactin family 7, subfamily d, member 1 (PRL7D1) is found in mouse placenta. Our recent work showed that PRL7D1 is also present in mouse testis Leydig cells, and the expression of PRL7D1 in the testis exhibits an age-related increase. In the present study, we generated transgenic mice with Leydig cell-specific PRL7D1 overexpression to explore its […]
IJMS, Vol. 17, Pages 92: Enrichment of Secondary Wastewater Sludge for Production of Hydrogen from Crude Glycerol and Comparative Evaluation of Mono-, Co- and Mixed-Culture Systems
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Anaerobic digestion using mixed-culture with broader choice of pretreatments for hydrogen (H2) production was investigated. Pretreatment of wastewater sludge by five methods, such as heat, acid, base, microwave and chloroform was conducted using crude glycerol (CG) as substrate. Results for heat treatment (100 °C for 15 min) showed the highest H2 production across the pretreatment […]
IJMS, Vol. 17, Pages 97: Nonalcoholic Fatty Liver Disease: Pros and Cons of Histologic Systems of Evaluation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
The diagnostic phenotype of nonalcoholic fatty liver disease (NAFLD)—in particular, the most significant form in terms of prognosis, nonalcoholic steatohepatitis (NASH)—continues to rely on liver tissue evaluation, in spite of remarkable advances in non-invasive algorithms developed from serum-based tests and imaging-based or sonographically-based tests for fibrosis or liver stiffness. The most common tissue evaluation remains […]
The Association of Peroxisome Proliferator-Activated Receptor δ and Additional Gene-Gene Interaction with C-Reac tive Protein in Chinese Population
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
Aims. To examine the association between 4 single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptors δ (PPARδ) polymorphisms and C-reactive protein (CRP) level and additional gene-gene interaction. Methods. Line regression analysis was performed to verify polymorphism association between SNP and CRP levels. Generalized multifactor dimensionality reduction (GMDR) was employed to analyze the interaction. Results. A […]
Deconstructing Complex Multimorbidity in the Very Old: Findings from the Newcastle 85+ Study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
Objectives. To examine the extent and complexity of the morbidity burden in 85-year-olds; identify patterns within multimorbidity; and explore associations with medication and healthcare use. Participants. 710 men and women; mean (SD) age 85.5 (0.4) years. Methods. Data on 20 chronic conditions (diseases and geriatric conditions) ascertained from general practice records and participant assessment. Cluster […]
Sudden ocular ptosis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
Publication date: Available online 12 January 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): J. Carvalho, S. Cahen-Riehm, C. Debry, A. Dupret-Bories from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RCD0UJ via IFTTT
Cancer-killing proteins destroy tumor cells in bloodstream
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
Cornell researchers have discovered potent cancer-killing proteins that can travel by white blood cells to kill tumours in the bloodstream of mice with metastatic prostate cancer. The breakthrough study will be published Feb. 10 in the Journal of… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PaERt0 via IFTTT
Colorectal cancer more likely to affect minorities at younger age
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
Colorectal cancer is the third most common form of cancer and the second most common cause of cancer deaths in the United States. The chance of developing colorectal cancer increases with age. Now, a study by University of Missouri School of Medicine… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mXntSs via IFTTT
Scientists re-engineer body’s immune system for safer and more effective cancer treatment
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
Scientists have demonstrated a new way of re-engineering the body’s immune system to target cancer, paving the way for a new generation of drugs, unprecedented in safety and effectiveness. Researchers from Cardiff University used powerful X-ray… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PaEQW0 via IFTTT
IJERPH, Vol. 13, Pages 122: The Impact of the 2008 Economic Crisis on Substance Use Patterns in the Countries of the European Union
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
Background: From 2008 on, a severe economic crisis (EC) has characterized the European Union (E.U.). However, changes in substance use behavioral patterns as a result of the economic crisis in Europe, have been poorly reflected upon, and underlying mechanisms remain to be identified; Methods: In this review we explore and systematize the available data on […]
Erratum to “NADPH Oxidase-Induced NALP3 Inflammasome Activation Is Driven by Thioredoxin-Interacting Protein Which Contributes to Podocyte Injury in Hyperglycemia”
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ZsKlue via IFTTT
Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
The present study aimed to examine the protective role of Spirulina platensis (S. platensis) against arsenic-induced testicular oxidative damage in rats. Arsenic (in the form of NaAsO2 at a dose of 6.3 mg/kg body weight for 8 weeks) caused a significant accumulation of arsenic in testicular tissues as well as a decrease in the levels of […]
Effect of ozone to remineralize initial enamel caries: in situ study
Abstract Objectives Effect of ozonated water in remineralizing artificially created initial enamel caries was investigated using laser fluorescence and polarized light microscopy in an in situ study. Materials and methods Teeth specimens (buccal sections) were immersed in 5-ml solution of 2 mM CaCl2, 2 mM NaH2P04, and 50 mM CH3COOH at pH of 4.55 for 5 h in an incubator at 37° to create subsurface demineralization. After which, they were randomly allocated into one of the following remineralization regimens: ozone (ozonated water 0.1 mg/l and 10 % nano-hydroxyapatite paste, Aclaim...περισσότερα »
Apical debris extrusion associated with oval shaped canals: a comparative study of WaveOne vs Self-Adjusting File
Abstract Objectives The aim was to evaluate ex vivo apical debris extrusion associated with WaveOne and Self-Adjusting File instruments when used in oval canals. Methods Twenty-four extracted human mandibular premolars with oval-shaped canals were assigned in two equal groups. Following coronal cavity preparation, a glide path was created. Group A was subjected to canal preparation using a WaveOne primary file, which was used along with syringe and needle irrigation and 10 mL of 2.4 % NaOCl solution, followed by flushing with 10 mL of 17 % EDTA solution, activation with EndoActiva...περισσότερα »
In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis
Abstract Objectives The aim of the present study was to assess the antimicrobial activity of a sodium hypochlorite formulation including its components against bacteria associated with periodontal disease. Materials and methods Sodium hypochlorite formulation (NaOCl gel), its components sodium hypochlorite (NaOCl), and the activating vehicle were compared with 0.1 % chlorhexidine digluconate (CHX) solution. The antimicrobial activity was proven by determination of minimal inhibitory concentrations (MIC), minimal bactericidal concentrations, and killing assays. Furthermore, the inf...περισσότερα »
Effects of design parameters on fracture resistance of glass simulated dental crowns
Publication date: Available online 13 January 2016 *Source:*Dental Materials Author(s): Zhongpu Zhang, Tanapon Sornsuwan, Chaiy Rungsiyakull, Wei Li, Qing Li, Michael V. Swain ObjectiveThis study aimed to individually quantify the effects of various design parameters, including margin thickness, convergence angle of abutment, and bonding conditions on fracture resistance of resin bonded glass dental crown systems (namely, glass simulated crown).Materials and methodsAn in vitro experimental test and an in silico computational eXtended Finite Element Method (XFEM) were adopted to expl...περισσότερα »
Laligam Sekhar, Richard G. Fessler: Atlas of neurosurgical techniques: brain, second edition, two volume set
from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1OZQARv via IFTTT
Comparison of the clinical and radiologic outcomes obtained with single- versus two-level anterior cervical decompression and fusion using stand-alone PEEK cages filled with allograft
Abstract Background Although anterior cervical decompression and fusion with a stand-alone cage (ACDF-SAC) is accepted as a suitable procedure, the outcomes of the multi-level procedure remain controversial. The aim of this study is to compare the clinical and radiologic outcomes achieved with single versus two-level ACDF-SAC along with identification of the factors that contribute to… Continue reading Comparison of the clinical and radiologic outcomes obtained with single- versus two-level anterior cervical decompression and fusion using stand-alone PEEK cages filled with allograft
Verstauchten Knöchel bei Kindern nicht eingipsen
Wachstumsfuge selten beteiligt Soll man Kinder mit verletztem Knöchel und Verdacht auf eine Beteiligung der fibulären Epiphysenfuge mit einem Gipsverband immobilisieren? Die Ergebnisse einer kanadischen Studie sprechen dagegen. Den Autoren zufolge liegen den Schmerzen und Schwellungen auch bei Kindern in den meisten Fällen Bandverletzungen zugrunde. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1OhG0BK via IFTTT
Bei Aknepatienten auf den Glukosestoffwechsel achten
Der Blick unter die Haut lohnt sich Aknepatienten plagen sich nicht nur mit lästigen Pickeln. Sie tragen zudem offenbar häufig ein paar kardiometabolische Risikofaktoren, die man im Auge behalten sollte, wie eine indische Studie nahelegt. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1ni0L7H via IFTTT
Human islet cells are killed by BID-independent mechanisms in response to FAS ligand
Abstract Cell death via FAS/CD95 can occur either by activation of caspases alone (extrinsic) or by activation of mitochondrial death signalling (intrinsic) depending on the cell type. The BH3-only protein BID is activated in the BCL-2-regulated or mitochondrial apoptosis pathway and acts as a switch between the extrinsic and intrinsic cell death pathways. We have… Continue reading Human islet cells are killed by BID-independent mechanisms in response to FAS ligand
Association between urinary 3-phenoxybenzoic acid and body mass index in Korean adults: 1 st Korean National Environmental Health Survey
Abstract Background According to US-EPA report, the use of pyrethrins and pyrethroids has increased during the past decade, and their area of use included not only in agricultural settings, but in commerce, and individual household. It is known that urinary 3-PBA, major metabolite of pyrethroid, have some associations with health effect in nervous and endocrine… Continue reading Association between urinary 3-phenoxybenzoic acid and body mass index in Korean adults: 1 st Korean National Environmental Health Survey
Perinatal Risk Factors for Feeding and Eating Disorders in Children Aged 0 to 3 Years
OBJECTIVE: To describe the incidence, age at diagnosis, and associations between perinatal risk factors of feeding and eating disorders (FED) diagnosed at hospital in children aged 0 to 3 years. METHODS: A nationwide cohort of 901 227 children was followed until 48 months of age in the national registers from 1997 to 2010. Multivariable Cox… Continue reading Perinatal Risk Factors for Feeding and Eating Disorders in Children Aged 0 to 3 Years
US Poison Control Center Calls for Infants 6 Months of Age and Younger
BACKGROUND: Anticipatory guidance and prevention efforts to decrease poisonings in young children have historically focused on restricting access to minimize exploratory ingestions. Because infants through 6 months of age have limited mobility, such exposures are expected to be less frequent and therapeutic (or dosing) errors should be more frequent. Although recent prevention efforts target some… Continue reading US Poison Control Center Calls for Infants 6 Months of Age and Younger
The Association of Peroxisome Proliferator-Activated Receptor δ and Additional Gene-Gene Interaction with C-Reac tive Protein in Chinese Population
Aims. To examine the association between 4 single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptors δ (PPARδ) polymorphisms and C-reactive protein (CRP) level and additional gene-gene interaction. Methods. Line regression analysis was performed to verify polymorphism association between SNP and CRP levels. Generalized multifactor dimensionality reduction (GMDR) was employed to analyze the interaction. Results. A… Continue reading The Association of Peroxisome Proliferator-Activated Receptor δ and Additional Gene-Gene Interaction with C-Reac tive Protein ... περισσότερα »
Deconstructing Complex Multimorbidity in the Very Old: Findings from the Newcastle 85+ Study
Objectives. To examine the extent and complexity of the morbidity burden in 85-year-olds; identify patterns within multimorbidity; and explore associations with medication and healthcare use. Participants. 710 men and women; mean (SD) age 85.5 (0.4) years. Methods. Data on 20 chronic conditions (diseases and geriatric conditions) ascertained from general practice records and participant assessment. Cluster… Continue reading Deconstructing Complex Multimorbidity in the Very Old: Findings from the Newcastle 85+ Study
Life expectancy and years of potential life lost after acute myocardial infarction by sex and race: a cohort-based study of medicare beneficiaries
The Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RLAv0p via IFTTT
An analysis of inhalation injury diagnostic methods and patient outcomes
Journal of Burn Care & Research from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RLAs4V via IFTTT
Prevalence and predictors of posttraumatic stress symptomatology among burn survivors: a systematic review and meta-analysis
Journal of Burn Care & Research from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1OqrTI6 via IFTTT
Association between UGT1A1 Polymorphism and Risk of Laryngeal Squamous Cell Carcinoma.
Related Articles *Association between UGT1A1 Polymorphism and Risk of Laryngeal Squamous Cell Carcinoma.* Int J Environ Res Public Health. 2016;13(1) Authors: Huangfu H, Pan H, Wang B, Wen S, Han R, Li L Abstract Laryngeal cancer is one of the largest subgroups of head and neck cancers. In addition to smoking and alcohol consumption, genetic polymorphisms are also risk factors for the development of laryngeal cancer. However, the exact relation between genetic variants and pathogenesis of laryngeal cancer has remained elusive. The aim of this study was to examine UGT1A1*6 (rs414... περισσότερα »
Laligam Sekhar, Richard G. Fessler: Atlas of neurosurgical techniques: brain, second edition, two volume set
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OZQARv via IFTTT
Comparison of the clinical and radiologic outcomes obtained with single- versus two-level anterior cervical decompression and fusion using stand-alone PEEK cages filled with allograft
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Abstract Background Although anterior cervical decompression and fusion with a stand-alone cage (ACDF-SAC) is accepted as a suitable procedure, the outcomes of the multi-level procedure remain controversial. The aim of this study is to compare the clinical and radiologic outcomes achieved with single versus two-level ACDF-SAC along with identification of the factors that contribute to […]
Verstauchten Knöchel bei Kindern nicht eingipsen
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Wachstumsfuge selten beteiligt Soll man Kinder mit verletztem Knöchel und Verdacht auf eine Beteiligung der fibulären Epiphysenfuge mit einem Gipsverband immobilisieren? Die Ergebnisse einer kanadischen Studie sprechen dagegen. Den Autoren zufolge liegen den Schmerzen und Schwellungen auch bei Kindern in den meisten Fällen Bandverletzungen zugrunde. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OhG0BK via IFTTT
Bei Aknepatienten auf den Glukosestoffwechsel achten
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Der Blick unter die Haut lohnt sich Aknepatienten plagen sich nicht nur mit lästigen Pickeln. Sie tragen zudem offenbar häufig ein paar kardiometabolische Risikofaktoren, die man im Auge behalten sollte, wie eine indische Studie nahelegt. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ni0L7H via IFTTT
Human islet cells are killed by BID-independent mechanisms in response to FAS ligand
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Abstract Cell death via FAS/CD95 can occur either by activation of caspases alone (extrinsic) or by activation of mitochondrial death signalling (intrinsic) depending on the cell type. The BH3-only protein BID is activated in the BCL-2-regulated or mitochondrial apoptosis pathway and acts as a switch between the extrinsic and intrinsic cell death pathways. We have […]
Association between urinary 3-phenoxybenzoic acid and body mass index in Korean adults: 1 st Korean National Environmental Health Survey
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
Abstract Background According to US-EPA report, the use of pyrethrins and pyrethroids has increased during the past decade, and their area of use included not only in agricultural settings, but in commerce, and individual household. It is known that urinary 3-PBA, major metabolite of pyrethroid, have some associations with health effect in nervous and endocrine […]
Perinatal Risk Factors for Feeding and Eating Disorders in Children Aged 0 to 3 Years
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
OBJECTIVE: To describe the incidence, age at diagnosis, and associations between perinatal risk factors of feeding and eating disorders (FED) diagnosed at hospital in children aged 0 to 3 years. METHODS: A nationwide cohort of 901 227 children was followed until 48 months of age in the national registers from 1997 to 2010. Multivariable Cox […]
US Poison Control Center Calls for Infants 6 Months of Age and Younger
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
BACKGROUND: Anticipatory guidance and prevention efforts to decrease poisonings in young children have historically focused on restricting access to minimize exploratory ingestions. Because infants through 6 months of age have limited mobility, such exposures are expected to be less frequent and therapeutic (or dosing) errors should be more frequent. Although recent prevention efforts target some […]
Common dementia drug found to improve Parkinson’s symptoms
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
Scientists have discovered that a commonly prescribed dementia drug could hold the key to helping prevent debilitating falls for people with Parkinson’s. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OhEGyP via IFTTT
Sudden ocular ptosis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
Publication date: Available online 12 January 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): J. Carvalho, S. Cahen-Riehm, C. Debry, A. Dupret-Bories from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RCD0UJ via IFTTT
Effects of Erythropoietin on Adipose Tissue: A Possible Strategy in Refilling
[image: image]Background: The increased resorption and the difficulty of the fat graft take following autologous fat transplantation procedure are associated with reduced fat tissue revascularization and increased apoptosis of adipose cells. We suppose that the lipofilling procedure induces an inflammatory environment within the fat graft mass, whose evolution influences the efficacy of autologous fat graft survival. Erythropoietin (EPO) is a glycoprotein hormone known to exert angiogenetic and anti-inflammatory effects; therefore, our purpose was to investigate its reaction with ad... περισσότερα »
Intrinsic astrocyte heterogeneity influences tumor growth in glioma mouse models
Abstract The influence of cellular origin on glioma pathogenesis remains elusive. We previously showed that mutations inactivating *Rb* and *Pten* and activating *Kras* transform astrocytes and induce tumorigenesis throughout the adult mouse brain. However, it remained unclear whether astrocyte subpopulations were susceptible to these mutations. We therefore used genetic lineage tracing and fate mapping in adult conditional, inducible genetically engineered mice to monitor transformation of GFAP and GLAST astrocytes and immunofluorescence to monitor cellular composition of the tum... περισσότερα »
Table of Contents: Runs into list of accepted articles and copyright block
from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1OhyoPO via IFTTT
Investigation of 5-HT2A gene expression in PBMCs of patients with allergic asthma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
(Source: Inflammation and Allergy Drug Targets) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PWt6tl via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Graphical Abstracts:
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This article is currently available as a free download on ingentaconnect (Source: Inflammation and Allergy Drug Targets) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mXidOV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Autologous adipose-derived stromal vascular fraction in patients with systemic sclerosis: 12-month follow-up
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective. Impaired hand function greatly contributes to disability and reduced quality of life in SSc patients. Autologous adipose-derived stromal vascular fraction (ADSVF) is recognized as an easily accessible source of regenerative cells. We reported positive 6-month safety and efficacy results from an open-label clinical trial assessing s.c. injection of autologous ADSVF into the fingers in […]
Effect of chemoradiotherapy on nutrition status of patients with nasopharyngeal cancer.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Authors: Hong JS, Wu LH, Su L, Zhang HR, Lv WL, Zhang WJ, Tian J Abstract We aimed to assess the effect of chemoradiotherapy on the nutritional status of patients with nasopharyngeal cancer (NPC) and to detect the risk factors for poor nutrition status in NPC patients after radiotherapy. A total of 104 NPC patients […]
Association between omega-3 fatty acids and serum prostate-specific antigen.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
We examined the association between omega-3 fatty acids (O3FAs) and prostate-specific antigen (PSA) in a cross-sectional analysis of 6219 men examined at the Cooper Clinic from 2009 to 2013. We assayed O3FAs from red blood cell membranes and measured PSA levels in study participants. Multiple logistic regression was used to examine the association between O3FAs […]
Variation of resting energy expenditure after the first chemotherapy cycle in acute leukemia patients.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This study aimed to assess changes in REE of acute leukemia adult patients before and after the first remission induction. Evaluation of REE was performed by indirect calorimetry and predicted REE was calculated by Harris-Benedict equation. Weight and height were measured and compared to a control group of healthy individuals. FFM was assessed by bioelectrical […]
Coffee consumption and the risk of incident gastric cancer-A meta-analysis of prospective cohort studies.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Authors: Deng W, Yang H, Wang J, Cai J, Bai Z, Song J, Zhang Z Abstract As several epidemiological studies on the association of coffee consumption with gastric cancer risk have produced inconsistent results, this meta-analysis was designed to synthesize current evidence of this potential relationship. We searched PubMed, EMBASE, and the Cochrane Library up […]
Differentiation of human innate lymphoid cells (ILCs).
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Authors: Juelke K, Romagnani C Abstract During the last years, a high complexity in innate lymphoid lineages now collectively referred to as innate lymphoid cells (ILCs) has been revealed. ILCs can be grouped according to their effector functions and transcriptional requirements into three main groups, termed group 1, 2 and 3 ILCs. The differentiation of […]
Cancer immune contexture and immunotherapy.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Authors: Becht E, Giraldo NA, Dieu-Nosjean MC, Sautès-Fridman C, Fridman WH Abstract The immune contexture that characterizes the density, the location, the organization and the functional orientation of tumor-infiltrating immune cells in cancers has a clinical impact on patient’s outcome. It is, in great part, shaped by the malignant cells, as in a given cancer […]
Phenotype and functions of conventional and non-conventional NK cells.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Authors: Erick TK, Brossay L Abstract Here we focus on the phenotypic and functional diversity of NK cells. We give an overview of the phenotype and developmental pathways of conventional and tissue-resident NK cells. We also discuss the potential complementary functions of conventional NK cells and tissue-resident NK cells in a variety of tissues. PMID: […]
Vulvovaginal candidosis: contemporary challenges and the future of prophylactic and therapeutic approaches
Summary Vulvovaginal candidosis (VVC) is a common gynaecological disorder that is delineated by the inflammation of vaginal wall and it is caused by the opportunistic fungal pathogen *Candida* species. In fact, three out of every four women will experience at least one occasion of VVC during some point in their lives. Although uncomplicated VVC is relatively harmless, the complicated VVC such as recurrent attack often creates restlessness and depression in the patients, thus greatly affects their quality of life. Managements of VVC are usually associated with the use of antimycotic... περισσότερα »
High frequency of Candida fabianii among clinical isolates biochemically identified as Candida pelliculosa and Candida utilis
Summary Clinical yeast isolates belonging to *Candida pelliculosa, Candida utilis* and *Candida fabianii* are difficult to distinguish in a routine mycology laboratory using common biochemical tests. The aims of this study were to determine the prevalence of *C. pelliculosa*, *C. utilis* and *C. fabianii* in clinical samples and to compare their minimum inhibitory concentrations (MICs) to systemic antifungals. Two hundred and forty-eight clinical yeast isolates obtained from eight large hospitals in the Czech Republic were included in this study. Identification was performed bioche... περισσότερα »
Contact allergy resulting from the use of acrylate nails is increasing in both users and those who are occupationally exposed
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Airborne allergic contact dermatitis caused by Apuleia leiocarpa in a parquet fitter
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Occupational contact allergy to the epoxy resin hardener 2-methylpentane-1,5-diamine
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Sensitization to cyanoacrylates caused by prolonged exposure to a glucose sensor set in a diabetic child
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Serum elevation of B lymphocyte stimulator does not increase regulatory B cells in glioblastoma patients undergoing immunotherapy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Regulatory B cells that secrete IL-10 (IL-10+ Bregs) represent a suppressive subset of the B cell compartment with prominent anti-inflammatory capacity, capable of suppressing cellular and humoral responses to cancer and vaccines. B lymphocyte stimulator (BLyS) is a key regulatory molecule in IL-10+ Breg biology with tightly controlled serum levels. However, BLyS levels can […]
8th Annual Canadian Cancer Immunotherapy Consortium (CCIC) Symposium 2015—May 20–22, Vancouver, Canada
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1mUGcy0 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Poly(I:C) potentiates Bacillus Calmette–Guérin immunotherapy for bladder cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Non-specific immunotherapy consisting of intravesical instillation of Bacillus Calmette–Guérin (BCG) is currently the best available treatment to prevent non-muscle-invasive bladder tumor recurrence and progression. This treatment however is suboptimal, and more effective immunotherapeutic approaches are needed. Toll-like receptors (TLRs) play a major role in the activation of the immune system in response to pathogens […]
Acknowledgement
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1mUG8P2 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
IL-6 down-regulates HLA class II expression and IL-12 production of human dendritic cells to impair activation of antigen-specific CD4 + T cells
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Immunosuppression in tumor microenvironments critically affects the success of cancer immunotherapy. Here, we focused on the role of interleukin (IL)-6/signal transducer and activator of transcription (STAT3) signaling cascade in immune regulation by human dendritic cells (DCs). IL-6-conditioned monocyte-derived DCs (MoDCs) impaired the presenting ability of cancer-related antigens. Interferon (IFN)-γ production attenuated by CD4+ T […]
Effectiveness of Thoracoscopic Talc Pleurodesis in the Management of Complicated Spontaneous Pneumothorax
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background: Complicated (recurring or persistent) spontaneous pneumothorax requires intervention either by surgical or nonsurgical pleurodesis or other interventions. As for high-risk patients, aggressive interventions may be associated with morbidity, the safety and effectiveness of less aggressive alternative interventions like thoracoscopic talc pleurodesis (TTP) should be evaluated. Methods: Data were extracted on patients who had undergone […]
Tracheal Fibroepithelial Polyp
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
No abstract available from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1ShGknW via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Cryotechnology in Diagnosing and Treating Lung Diseases
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Cryotechnology has been used in treating lung cancer for many years, now it is emerging to have a new indication in diagnosing lung diseases. Cryoprobe transbronchial lung biopsy has been introduced into clinical practice as a new technique, providing a larger biopsy specimen, potentially improving the diagnostic yield of transbronchial biopsies in parenchymal lung diseases. […]
The Effect of General Anesthesia Versus Intravenous Sedation on Diagnostic Yield and Success in Electromagnetic Navigation Bronchoscopy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background: Navigational bronchoscopy is utilized to guide biopsies of peripheral lung nodules and place fiducial markers for treatment of limited stage lung cancer with stereotactic body radiotherapy. The type of sedation used for this procedure remains controversial. We performed a retrospective chart review to evaluate the differences of diagnostic yield and overall success of the […]
Endobronchial Ultrasound-guided Transbronchial Needle Aspiration: Indian Perspective
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
No abstract available from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1OhypmG via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
7-prenyloxi-6-methoxycoumarin from Polygala sabulosa A.W. Bennett Regulates p38 MAPK and NF-kB Pathways Inhibiting the Inflammation Induced by Carrageenan in the Mouse Model of Pleurisy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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In vitro effects of infrared A radiation on the synthesis of MMP-1, catalase, superoxide dismutase and GADD45 alpha protein
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Analgesic and Anti-Inflammatory Properties of Arylnitroalkenes
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Design, Synthesis and In Vitro Release Studies of Co-Drugs for Rheumatoid Arthritis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Cardiovascular Magnetic Resonance Imaging clarifies cardiac pathophysiology in early, asymptomatic diffuse systemic sclerosis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Compounds Derived from Epigallocatechin-3-Gallate (EGCG) as a Novel Approach to the Prevention of Viral Infections
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Editorial: Challenge for the European Union: Immigrant and Refugee Health
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
This article is currently available as a free download on ingentaconnect (Source: Inflammation and Allergy Drug Targets) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mXieSU via IFTTT
Gut Homing Molecule Regulation of the Pathogenesis and Treatment of Inflammatory Bowel Diseases
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Meet Our Editor:
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
This article is currently available as a free download on ingentaconnect (Source: Inflammation and Allergy Drug Targets) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mXicdO via IFTTT
Investigation of 5-HT2A gene expression in PBMCs of patients with allergic asthma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Trigeminocardiac reflex and haemodynamic changes during Le Fort I osteotomy
The Le Fort I osteotomy is performed under general anaesthesia and specific haemodynamic conditions, i.e. hypotensive general anaesthesia. This study assessed the incidence of the trigeminocardiac reflex (TCR) during the different stages of the Le Fort I osteotomy. Forty-seven patients requiring a Le Fort I osteotomy were included. General anaesthesia was induced. In terms of haemodynamic changes, each patient's oxygen saturation (SpO2), mean arterial pressure (MAP), heart rate (HR), and electrocardiogram (ECG) were monitored by SADAAT Monitoring System and recorded during the dif...περισσότερα »
Three-dimensional maxillary and mandibular regional superimposition using cone beam computed tomography: a validation study
This study aimed to validate a novel method for fast regional superimposition of cone beam computed tomography (CBCT) scans. The method can be used with smaller field of view scans, thereby allowing for a lower radiation dose. This retrospective study used two dry skulls and secondary data from 15 patients who had more than one scan taken using the same machine. Two observers tested two types of regional voxel-based superimposition: maxillary and mandibular. The registration took 10–15s. Three-dimensional surface models of the maxillas and mandibles were generated via standardized... περισσότερα »
Columella-stabilising suture: a simple adjunct to nasal septal surgery
Septal deviation, whatever the cause, may disturb the form and function of the nose, and can range from a mild aesthetic problem at the caudal septal end to a more severe and complex deformity resulting in collapse of the tip, severe deviation, and nasal obstruction. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1ShmQzL via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Sugar Consumption and Changes in Dental Caries from Childhood to Adolescence
There are no prospective studies investigating the effects of sugar-related feeding practices on changes in dental caries from early childhood to young adulthood. The aim of this study was to assess whether sugar-related feeding practices affect dental caries between the ages of 6 and 18 y. This birth cohort study was initiated in 1993 in Pelotas, Brazil. There were 3 dental clinical assessments; at ages 6 y (*n* = 359), 12 y (*n* = 339), and 18 y (*n* = 307). Sugar-related feeding practices were assessed at ages 4, 15, and 18 y. Covariates included sex and life course variables, s... περισσότερα »
Two-week rule in head and neck cancer 2000-14: a systematic review
The fast-track system in the UK for patients with suspected cancer – the two-week rule - states that if cancer is suspected there should be a maximum of 14 days between referral from primary care and consultation with a specialist. This approach is valued by patients, ensures a universal standard of diagnosis, and speeds up the overall management of cancer. However, some say that the rule has had little or no effect on survival, results in a diagnosis of cancer in only a small proportion of patients referred, and is expensive. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader ht... περισσότερα »
Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS
Abstract Introduction Amyotrophic lateral sclerosis (ALS) is a motor neuron disease with a gender bias towards major prevalence in male individuals. Several data suggest the involvement of oxidative stress and mitochondrial dysfunction in its pathogenesis, though differences between genders have not been evaluated. For this reason, we analysed features of mitochondrial oxidative metabolism, as well as mitochondrial chain complex enzyme activities and protein expression, lipid profile, and protein oxidative stress markers, in the Cu,Zn superoxide dismutase with the G93A mutation (hS... περισσότερα »
Farewell to GBM-O: Genomic and transcriptomic profiling of glioblastoma with oligodendroglioma component reveals distinct molecular subgroups
Abstract Introduction Glioblastoma with oligodendroglioma component (GBM-O) was recognized as a histologic pattern of glioblastoma (GBM) by the World Health Organization (WHO) in 2007 and is distinguished by the presence of oligodendroglioma-like differentiation. To better understand the genetic underpinnings of this morphologic entity, we performed a genome-wide, integrated copy number, mutational and transcriptomic analysis of eight (seven primary, primary secondary) cases. Results Three GBM-O samples had *IDH1* (p.R132H) mutations; two of these also demonstrated 1p/19q co-dele... περισσότερα »
Perampanel as add-on treatment in refractory focal epilepsy. The Dianalund experience
Background Perampanel (PER) is an antagonist of AMPA receptors that has been approved for adjunctive treatment of partial-onset seizures. Aims To evaluate effectiveness and safety of PER as add-on treatment in patients with severely refractory focal epilepsy. Methods PER was introduced as add-on treatment in 22 consecutive patients with drug-resistant focal epilepsy. PER was started with 2 mg/day at bedtime and was up-titrated by 2 mg/day every 2–4 weeks. Results All patients suffered from severely refractory focal epilepsy (86% took 2 or more AEDs prior PER initiation; 40% ha...περισσότερα »
Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals
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Animal Models for the Study of Subarachnoid Hemorrhage: Are We Moving Towards Increased Standardization?
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The contribution of ultrasonic vocalizations to mouse courtship
[image: S09594388.gif] Publication date: June 2016 *Source:*Current Opinion in Neurobiology, Volume 38 Author(s): SE Roian Egnor, Kelly M Seagraves Vocalizations transmit information to social partners, and mice use these signals to exchange information during courtship. Ultrasonic vocalizations from adult males are tightly associated with their interactions with females, and vary as a function of male quality. Work in the last decade has established that the spectrotemporal features of male vocalizations are not learned, but that female attention toward specific vocal features is m... περισσότερα »
Long-term efficacy and safety of etravirine-containing regimens in a real-life cohort of treatment-experienced HIV-1-infected patients
10.3109/23744235.2015.1133927<br>Clotilde Allavena from Infection via ola Kala on Inoreader http://ift.tt/1KcLzO2 via IFTTT
The changing epidemiology of group B streptococcus bloodstream infection: A multi-national population-based assessment
10.3109/23744235.2015.1131330<br>Mark S. Ballard from Infection via ola Kala on Inoreader http://ift.tt/1RCumpd via IFTTT
Sugar Consumption and Changes in Dental Caries from Childhood to Adolescence
There are no prospective studies investigating the effects of sugar-related feeding practices on changes in dental caries from early childhood to young adulthood. The aim of this study was to assess whether sugar-related feeding practices affect dental caries between the ages of 6 and 18 y. This birth cohort study was initiated in 1993 in Pelotas, Brazil. There were 3 dental clinical assessments; at ages 6 y (*n* = 359), 12 y (*n* = 339), and 18 y (*n* = 307). Sugar-related feeding practices were assessed at ages 4, 15, and 18 y. Covariates included sex and life course variables, s... περισσότερα »
Longitudinal Multilevel Modeling of Facial Pain, Muscle Tension, and Stress
The role of masticatory muscle activation on pain in temporomandibular muscle and joint disorders (TMJD) is controversial. This single-group, prospective panel study examined the relationships among masticatory muscle tension, emotional distress, and TMJD pain in a sample of 7,023 observations obtained from 171 individuals using longitudinal multilevel modeling. Three main hypotheses were tested. The first posited that emotional distress and muscle tension directly influenced pain (hypothesis 1a: Distress -> TMJD Pain; hypothesis 1b: Muscle Tension -> TMJD Pain). The second posite... περισσότερα »
Coffee consumption and the risk of incident gastric cancer-A meta-analysis of prospective cohort studies.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Authors: Deng W, Yang H, Wang J, Cai J, Bai Z, Song J, Zhang Z Abstract As several epidemiological studies on the association of coffee consumption with gastric cancer risk have produced inconsistent results, this meta-analysis was designed to synthesize current evidence of this potential relationship. We searched PubMed, EMBASE, and the Cochrane Library up […]
