Attenuated total reflection fourier transform infrared spectroscopy towards disclosing mechanism of bacterial adhesion on thermally stabilized titanium nano-interfaces
Abstract Titanium is widely used as medical implant material and as condenser material in the nuclear industry where its integrity is questioned due to its susceptibility to bacterial adhesion. A systematic investigation on the influence of thermally (50–800 °C) stabilized titanium (TS-Ti) nano oxide towards bacterial adhesion was carried out. The results showed that below 350 °C significant bacterio-phobicity was observed, while above 500 °C significant affinity towards bacterial cells was recorded. Conventional characterization tools such as HR-TEM and XRD did not provide much in... περισσότερα »
Copper(I) Thiolate Heteroadamantane Cage Structures with Relevance to Metalloproteins
Cu–S heteroadamantanes are of great interest owing to their relevance to bioproteins. New copper(I) thiolate compounds with additional N-donor functions from phenanthroline ligands have been synthesised. These complexes feature heteroadamantane cage structures with minor deviations in their construction and, therefore, a strong structural relationship. Furthermore, a decanuclear copper–sulfur cluster complex was isolated and shows known structural motifs arranged in a new fashion. Metallothioneins are natural counterparts to these complexes due to their thiolate-rich and polynucl... περισσότερα »
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Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 1 λεπτό
[image: BioMed Central – The Open Access Publisher] BMC Biology Impact Factor: 6.967 BMC Biology Impact Factor: 6.967 Submit Manuscript | Editorial Board | Submission Guidelines | Article Alerts Dear Dr Sfakianakis, Please see below our latest content update, including new articles and featured articles. ------------------------------ Featured Articles What is memory? – A Forum of experts [image: What is memory? – A Forum of experts] Where and how are memories acquired, stored and retrieved? In a Forum guest-edited by Mu-ming Poo, leading researcher... περισσότερα »
Otosclerosis Associated with a De Novo Mutation -832G > A in the TGFB1 Gene Promoter Causing a Decreased Expression Level.
*Otosclerosis Associated with a De Novo Mutation -832G > A in the TGFB1 Gene Promoter Causing a Decreased Expression Level.* Sci Rep. 2016;6:29572 Authors: Priyadarshi S, Hansdah K, Ray CS, Biswal NC, Ramchander PV Abstract Otosclerosis (OTSC) is defined by abnormal bone remodeling in the otic capsule of middle ear which leads to conductive hearing loss. In our previous study, we have identified a de novo heterozygous mutation -832G > A in the promoter of TGFB1 in an otosclerosis patient. In the present study, we progressively screened this mutation in a cohort of 254 cases and 2... περισσότερα »
Study of Effect of Household Parental Smoking on Development of Acute Otitis Media in Children Under 12 Years.
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Study of Effect of Household Parental Smoking on Development of Acute Otitis Media in Children Under 12 Years.* Glob J Health Sci. 2016 May;8(5):81-8 Authors: Amani S, Yarmohammadi P Abstract BACKGROUND & AIM: High prevalence of acute otitis media (AOM) in children represents a combination of the factors developing eustachian tube dysfunction and higher susceptibility to upper respiratory tract infections in children. This disease is relatively prevalent in Iran and much cost is spent annually to treat it. This study investi... περισσότερα »
Seizure-onset patterns in focal cortical dysplasia and neurodevelopmental tumors: Relationship with surgical prognosis and neuropathologic subtypes
Summary Objectives The study of intracerebral electroencephalography (EEG) seizure-onset patterns is crucial to accurately define the epileptogenic zone and guide successful surgical resection. It also raises important pathophysiologic issues concerning mechanisms of seizure generation. Until now, several seizure-onset patterns have been described using distinct recording methods (subdural, depth electrode), mostly in temporal lobe epilepsies or with heterogeneous neocortical lesions. Methods We analyzed data from a cohort of 53 consecutive patients explored by stereoelectroence... περισσότερα »
A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance.
[image: http:--http://ift.tt/1feGv2I] Related Articles *A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance.* Cancer Gene Ther. 2015 Sep;22(9):417-30 Authors: Dietel M, Jöhrens K, Laffert MV, Hummel M, Bläker H, Pfitzner BM, Lehmann A, Denkert C, Darb-Esfahani S, Lenze D, Heppner FL, Koch A, Sers C, Klauschen F, Anagnostopoulos I Abstract In April 2013 our group published a review on predictive molecular pathology in this journal. Although only 2 years have passed many new facts and stimulating developm... περισσότερα »
Are General Physicians Prepared for Struggling Skin Cancer?—Cross-Sectional Study
Abstract The aim of this study is to evaluate the role of general practitioners (GP) in selecting higher risk population for skin cancer screening. GP's training was organized to examine a specific high risk population consisting mainly of fisherman and farmers in a city of North of Portugal. Health care professionals of local health units training was performed by two dermatologists 2 months before the screening. During 8 weeks GPs selected patients with skin cancer suspicious lesions and/or risk factors consecutively from their regular consultation. These selected patients were ... περισσότερα »
Refractory Hypoxemia After Laparoscopic Nissen Fundoplication.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Refractory Hypoxemia After Laparoscopic Nissen Fundoplication.* Can J Cardiol. 2016 Mar;32(3):395.e1-3 Authors: Rochlani Y, Vallurupalli S, Hakeem A, Bhatti S Abstract Postoperative hypoxemia can result from a variety of causes. We describe a case of platypnea-orthodeoxia caused by shunting across a patent foramen ovale in a 72-year-old woman immediately after a laparoscopic Nissen fundoplication procedure. This was diagnosed by echocardiography and treated successfully with percutaneous device closure. An intraca... περισσότερα »
Feeding Challenges in Patients with Esophageal and Gastroesophageal Cancers.
*Feeding Challenges in Patients with Esophageal and Gastroesophageal Cancers.* Gastrointest Tumors. 2016 May;2(4):166-77 Authors: Reim D, Friess H Abstract BACKGROUND: Patients undergoing treatment for esophagogastric or esophageal cancer are exposed to a considerably high risk of malnutrition due to early obstruction of the gastrointestinal passage. Presently most of the patients undergo modern multimodal therapies which require chemoradiation or chemotherapy ahead of surgery. Therefore reconstruction of the obstructed gastrointestinal passage is considerably delayed. Surgery as... περισσότερα »
Presentation, Management, and Outcome of Thyroglossal Duct Cysts in Adult and Pediatric Populations: A 14-Year Single Center Experience.
*Presentation, Management, and Outcome of Thyroglossal Duct Cysts in Adult and Pediatric Populations: A 14-Year Single Center Experience.* Oman Med J. 2016 Jul;31(4):276-83 Authors: Al-Thani H, El-Menyar A, Sulaiti MA, El-Mabrok J, Hajaji K, Elgohary H, Asim M, Taha I, Tabeb A Abstract OBJECTIVES: A thyroglossal duct cyst (TDC) is a frequent congenital midline anomaly of the neck that usually manifests during the first decade of life. We aimed to describe the presentation, management, and outcome of TDC in pediatric and adult cases. METHODS: A retrospective observational analysis ... περισσότερα »
Teaching NeuroImages: Medullary lesions causing dysphagia in Leigh/MELAS overlap syndrome.
*Teaching NeuroImages: Medullary lesions causing dysphagia in Leigh/MELAS overlap syndrome.* Neurology. 2016 Jul 12;87(2):e18-9 Authors: Aravamuthan BR, Nath AR, Ghosh PS PMID: 27402949 [PubMed - in process] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/29vc5ef
Peripheral nerve sheath tumors arising in salivary glands: A clinicopathologic study.
*Peripheral nerve sheath tumors arising in salivary glands: A clinicopathologic study.* Ann Diagn Pathol. 2016 Aug;23:38-42 Authors: Guraya SS, Prayson RA Abstract Primary salivary gland peripheral nerve sheath tumors (PNST) are uncommon. This study is a retrospective, clinicopathologic review of 9 cases of PNST (5 neurofibromas, 3 schwannomas and 1 malignant peripheral nerve sheath tumor (MPNST)) arising from the salivary glands, encountered between 1990 and 2015. All patients with neurofibromas were male (ages 1-62 years) and had a single parotid lesion of which 2 were diffuse,... περισσότερα »
The Use of Cervical Auscultation to Predict Oropharyngeal Aspiration in Children: A Randomized Controlled Trial.
*The Use of Cervical Auscultation to Predict Oropharyngeal Aspiration in Children: A Randomized Controlled Trial.* Dysphagia. 2016 Jul 11; Authors: Frakking TT, Chang AB, O'Grady KF, David M, Walker-Smith K, Weir KA Abstract In this study, we aimed to determine if the use of cervical auscultation (CA) as an adjunct to the clinical feeding evaluation (CFE + CA) improves the reliability of predicting oropharyngeal aspiration (abbreviated to aspiration) in children. The design of the study is based on open label, randomized controlled trial with concealed allocation. Results from ch... περισσότερα »
Efficacy of pneumodilation in achalasia after failed Heller myotomy.
*Efficacy of pneumodilation in achalasia after failed Heller myotomy.* Neurogastroenterol Motil. 2016 Jul 11; Authors: Saleh CM, Ponds FA, Schijven MP, Smout AJ, Bredenoord AJ Abstract BACKGROUND: Heller myotomy is an effective treatment for the majority of achalasia patients. However, a small proportion of patients suffer from persistent or recurrent symptoms after surgery and they are usually subsequently treated with pneumodilation (PD). Data on the efficacy of PD as secondary treatment for achalasia are scarce. Therefore, this study aimed to investigate the efficacy of PD as t... περισσότερα »
Population attributable fraction of Esophageal squamous cell carcinoma due to smoking and alcohol in Uganda.
*Population attributable fraction of Esophageal squamous cell carcinoma due to smoking and alcohol in Uganda.* BMC Cancer. 2016;16:446 Authors: Okello S, Churchill C, Owori R, Nasasira B, Tumuhimbise C, Abonga CL, Mutiibwa D, Christiani DC, Corey KE Abstract BACKGROUND: Despite the high rates and regional variation of esophageal squamous cell carcinoma (ESCC) in East Africa, the contributions of smoking and alcohol to the ESCC burden in the general population are unknown. METHODS: We conducted a case-control study of patients presenting for upper gastrointestinal endoscopic examin... περισσότερα »
[Clinical pilot study on the rhinitis due to laryngopharyngeal reflux].
*[Clinical pilot study on the rhinitis due to laryngopharyngeal reflux].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Feb;30(3):200-2 Authors: Wu Y, Liang F Abstract OBJECTIVE: To explore the relevance between nasal symptoms and laryngopharyngeal reflux disease in patients with allergic rhinitis. METHOD: Thirty patients of laryngopharyngeal reflux disease were diagnosed in ENT outpatient department in our hospital. All patients have symptoms of sneeze, nasal discharge as chief complaint and they responded no effect for other normal treatment for nasal-sinusitis at least th... περισσότερα »
[Risk factors and clinical characteristics of gastroesophageal reflux disease: analysis based on a prospective database of functional gastrointestinal disease].
Related Articles *[Risk factors and clinical characteristics of gastroesophageal reflux disease: analysis based on a prospective database of functional gastrointestinal disease].* Nan Fang Yi Ke Da Xue Xue Bao. 2016 May;36(5):710-3 Authors: Chen LP, Huang ZW, Xiao B Abstract OBJECTIVE: To explore the risk factors and clinical characteristics of non-erosive reflux disease (NERD) based on a prospective single disease database of functional gastrointestinal disease. METHODS: Using a customized case report form, we collected the personal and clinical data of all study participants in ... περισσότερα »
[Heartburn spoils the noon nap].
[image: http:--production.springer.de-OnlineReso] Related Articles *[Heartburn spoils the noon nap].* MMW Fortschr Med. 2016 Apr 14;158(7):34 Authors: Madisch A PMID: 27071577 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/29wsPhn
Long-Term Benefits of Smoking Cessation on Gastroesophageal Reflux Disease and Health-Related Quality of Life.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Long-Term Benefits of Smoking Cessation on Gastroesophageal Reflux Disease and Health-Related Quality of Life.* PLoS One. 2016;11(2):e0147860 Authors: Kohata Y, Fujiwara Y, Watanabe T, Kobayashi M, Takemoto Y, Kamata N, Yamagami H, Tanigawa T, Shiba M, Watanabe T, Tominaga K, Shuto T, Arakawa T Abstract OBJECTIVE: Smoking is associated with gastroesophageal reflux disease (GERD). Varenicline, a nicotinic receptor partial agonist, is used to aid smoking cessation. The purpose of this stud... περισσότερα »
Refractory Hypoxemia After Laparoscopic Nissen Fundoplication.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Refractory Hypoxemia After Laparoscopic Nissen Fundoplication.* Can J Cardiol. 2016 Mar;32(3):395.e1-3 Authors: Rochlani Y, Vallurupalli S, Hakeem A, Bhatti S Abstract Postoperative hypoxemia can result from a variety of causes. We describe a case of platypnea-orthodeoxia caused by shunting across a patent foramen ovale in a 72-year-old woman immediately after a laparoscopic Nissen fundoplication procedure. This was diagnosed by echocardiography and treated successfully with percutaneous device closure. An intracar... περισσότερα »
Differential Regulation of Autophagy and Mitophagy in Pulmonary Diseases.
Differential Regulation of Autophagy and Mitophagy in Pulmonary Diseases. Am J Physiol Lung Cell Mol Physiol. 2016 Jul 8;:ajplung.00128.2016 Authors: Aggarwal S, Mannam P, Zhang J Abstract Lysosomal mediated degradation of intracellular lipids, proteins and organelles, known as autophagy, represents a inducible adaptive response to lung injury resulting from exposure to insults, such as hypoxia,… Continue reading Differential Regulation of Autophagy and Mitophagy in Pulmonary Diseases.
Clinical characteristics of 100 vestibular migraine cases.
[Clinical characteristics of 100 vestibular migraine cases]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Mar;30(5):399-401 Authors: Chen J, Gong D, Cai S, Wu Z, Lin X, Ma X, Yu L Abstract OBJECTIVE: To analyze the characteristics of vestibular migraine (VM), in order to understand the auditory and vestibular function.… Continue reading Clinical characteristics of 100 vestibular migraine cases.
The Role of MicroRNAs and Their Targets in Osteoarthritis.
The Role of MicroRNAs and Their Targets in Osteoarthritis. Curr Rheumatol Rep. 2016 Aug;18(8):56 Authors: Sondag GR, Haqqi TM Abstract Micro ribonucleic acid (microRNA) regulation and expression has become an emerging field in determining the mechanisms regulating a variety of inflammation-mediated diseases. Several studies have focused on specific microRNAs that are differentially expressed in cases… Continue reading The Role of MicroRNAs and Their Targets in Osteoarthritis.
Type 1 Hyperlipoproteinemia due to Compound Heterozygous Rare Variants in GCKR.
Type 1 Hyperlipoproteinemia due to Compound Heterozygous Rare Variants in GCKR. J Clin Endocrinol Metab. 2016 Jul 12;:jc20162179 Authors: Shetty S, Xing C, Garg A Abstract BACKGROUND: Type 1 hyperlipoproteinemia (T1HLP) is a rare, autosomal recessive disorder characterized by extreme elevations in serum triglyceride (TG) levels. Despite considerable progress in identifying several causal genes for… Continue reading Type 1 Hyperlipoproteinemia due to Compound Heterozygous Rare Variants in GCKR.
Accessory Interaction Motifs in the Atg19 Cargo Receptor Enable Strong Binding to the Clustered Ubiquitin-Related Atg8 Protein.
Accessory Interaction Motifs in the Atg19 Cargo Receptor Enable Strong Binding to the Clustered Ubiquitin-Related Atg8 Protein. J Biol Chem. 2016 Jul 11; Authors: Abert C, Kontaxis G, Martens S Abstract Selective autophagy contributes to cellular homeostasis by delivering harmful material into the lysosomal system for degradation via vesicular intermediates referred to as autophagosomes. The… Continue reading Accessory Interaction Motifs in the Atg19 Cargo Receptor Enable Strong Binding to the Clustered Ubiquitin-Related Atg8 Protein.
Sex hormones and sleep in men and women from the general population: a cross-sectional observational study.
Sex hormones and sleep in men and women from the general population: a cross-sectional observational study. J Clin Endocrinol Metab. 2016 Jul 12;:jc20161832 Authors: Kische H, Ewert R, Fietze I, Gross S, Wallaschofski H, Völzke H, Dörr M, Nauck M, Obst A, Stubbe B, Penzel T, Haring R Abstract CONTEXT AND OBJECTIVES: Associations between sex… Continue reading Sex hormones and sleep in men and women from the general population: a cross-sectional observational study.
Metformin targeting autophagy overcomes progesterone resistance in endometrial carcinoma.
Metformin targeting autophagy overcomes progesterone resistance in endometrial carcinoma. Arch Gynecol Obstet. 2016 Jul 11; Authors: Zhuo Z, Wang A, Yu H Abstract PURPOSE: Metformin is the most prescribed anti-diabetic medication worldwide because of its proven efficacy and limited side effects. In this study, the significant anticancer effect of metformin was investigated in both endometrial… Continue reading Metformin targeting autophagy overcomes progesterone resistance in endometrial carcinoma.
Ειδοποίηση Μελετητή – Foreign Body Aspiration
Ειδοποίηση Μελετητή:[ Foreign Body Aspiration ] Single-Use Detergent Sacs: A Retrospective Multicenter Canadian Review of Emergency Department Cases. D Rosenfield, M Eltorki, S VandenBerg, D Allain… – Pediatric Emergency Care, 2016 Background: Single-use detergent sacs (SUDS) are widely used in North America and Europe with emergi. Onychophagia: A nail-biting conundrum for physicians P Halteh, RK… Continue reading Ειδοποίηση Μελετητή – Foreign Body Aspiration
Ειδοποίηση Μελετητή – Ear’s Diseases
Ειδοποίηση Μελετητή:[ Ear’s Diseases ] MICROBIOTA MANAGEMENT FOR THE PREVENTION OF RECURRENT EAR AND THORAT INFECTIONS C Gerritsen, E Grahn-Håkansson, K Roos – Journal of Pediatric Gastroenterology and …, 2016 … This commonly includes diseases like tonsillitis, pharyngitis, laryngitis, sinusitis, otitis media and the … Spray bacteriotherapy decreases middle ear fluid in children with secretory… Continue reading Ειδοποίηση Μελετητή – Ear’s Diseases
Ειδοποίηση Μελετητή – Nose’s Diseases
Ειδοποίηση Μελετητή:[ Nose’s Diseases ] Effects of mineralocorticoid receptor blockade on empathy in patients with major depressive disorder K Wingenfeld, LK Kuehl, I Dziobek, S Roepke, C Otte… – Cognitive, Affective, & amp; …, 2016 … Of note, diverging patterns of cognitive and emotional empathy deficits have helped distinguishing diag- noses with known involvement of …… Continue reading Ειδοποίηση Μελετητή – Nose’s Diseases
Unilateral Clearance for Primary Hyperparathyroidism in Selected Patients with Multiple Endocrine Neoplasia Type 1.
*Unilateral Clearance for Primary Hyperparathyroidism in Selected Patients with Multiple Endocrine Neoplasia Type 1.* World J Surg. 2016 Jul 11; Authors: Kluijfhout WP, Beninato T, Drake FT, Vriens MR, Gosnell J, Shen WT, Suh I, Liu C, Duh QY Abstract BACKGROUND: Primary hyperparathyroidism is the most common manifestation of multiple endocrine neoplasia type 1 (MEN1). Guidelines advocate subtotal parathyroidectomy (STP) or total parathyroidectomy with autotransplantation due to high prevalence of multiglandular disease; however, both are associated with a significant risk of per... περισσότερα »
Validation study of HPV DNA detection from stained FNA smears by polymerase chain reaction: Improving the diagnostic workup of patients with a tumor on the neck.
*Validation study of HPV DNA detection from stained FNA smears by polymerase chain reaction: Improving the diagnostic workup of patients with a tumor on the neck.* Cancer Cytopathol. 2016 Jul 12; Authors: Channir HI, Grønhøj Larsen C, Ahlborn LB, van Overeem Hansen T, Gerds TA, Charabi BW, Vainer B, von Buchwald C, Lajer CB, Kiss K Abstract BACKGROUND: Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) often presents with cystic cervical metastasis and a small primary tumor localized in the palatine tonsils or base of the tongue, which is diagnostica... περισσότερα »
Novel Silicone-Coated 125I Seeds for the Treatment of Extrahepatic Cholangiocarcinoma.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Novel Silicone-Coated 125I Seeds for the Treatment of Extrahepatic Cholangiocarcinoma.* PLoS One. 2016;11(2):e0147701 Authors: Lin L, Guo L, Zhang W, Cai X, Chen D, Wan X Abstract 125I seeds coated with titanium are considered a safe and effective interstitial brachytherapy for tumors, while the cost of 125I seeds is a major problem for the patients implanting lots of seeds. The aim of this paper was to develop a novel silicone coating for 125I seeds with a lower cost. In order to show ... περισσότερα »
[Clinical characteristics of 100 vestibular migraine cases].
*[Clinical characteristics of 100 vestibular migraine cases].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Mar;30(5):399-401 Authors: Chen J, Gong D, Cai S, Wu Z, Lin X, Ma X, Yu L Abstract OBJECTIVE: To analyze the characteristics of vestibular migraine (VM), in order to understand the auditory and vestibular function. METHOD: One hundred cases of confirmed or suspected VM patients were observed. Routine examination including pure tone test, vestibular dual temperature test and vestibular evoked myogenic potential(VEMP) and video head impulse test(v-HIT) Were conducted. R... περισσότερα »
Type 1 Hyperlipoproteinemia due to Compound Heterozygous Rare Variants in GCKR.
*Type 1 Hyperlipoproteinemia due to Compound Heterozygous Rare Variants in GCKR.* J Clin Endocrinol Metab. 2016 Jul 12;:jc20162179 Authors: Shetty S, Xing C, Garg A Abstract BACKGROUND: Type 1 hyperlipoproteinemia (T1HLP) is a rare, autosomal recessive disorder characterized by extreme elevations in serum triglyceride (TG) levels. Despite considerable progress in identifying several causal genes for T1HLP such as, LPL, APOC2, APOA5, LMF1 and GPIHBP1, the molecular basis of some extremely rare patients presenting with T1HLP remains obscure. CASE DESCRIPTION: We report a 58-year-ol... περισσότερα »
Sex hormones and sleep in men and women from the general population: a cross-sectional observational study.
*Sex hormones and sleep in men and women from the general population: a cross-sectional observational study.* J Clin Endocrinol Metab. 2016 Jul 12;:jc20161832 Authors: Kische H, Ewert R, Fietze I, Gross S, Wallaschofski H, Völzke H, Dörr M, Nauck M, Obst A, Stubbe B, Penzel T, Haring R Abstract CONTEXT AND OBJECTIVES: Associations between sex hormones and sleep habits originate mainly from small and selected patient-based samples. We examined data from a population-based sample with various sleep characteristics and the major part of sex hormones measured by mass spectrometry. DES... περισσότερα »
A novel phenotype of familial hyperaldosteronism type III: Concurrence of aldosteronism and Cushing's syndrome.
*A novel phenotype of familial hyperaldosteronism type III: Concurrence of aldosteronism and Cushing's syndrome.* J Clin Endocrinol Metab. 2016 Jul 12;:jc20161504 Authors: Tong A, Liu G, Wang F, Jiang J, Yan Z, Zhang D, Zhang Y, Cai J Abstract CONTEXT: To date, all the familial hyperaldosteronism type III (FH-III) patients reported presented with typical primary aldosteronism (PA), without showing other adrenal hormone abnormalities. OBJECTIVE: This study characterized a novel phenotype of FH-III, and explored the possible pathogenesis. PATIENTS AND METHODS: A male patient presente... περισσότερα »
The Long Term Outcome Of Boys With Partial Androgen Insensitivity Syndrome And A Mutation In The Androgen Receptor Gene.
*The Long Term Outcome Of Boys With Partial Androgen Insensitivity Syndrome And A Mutation In The Androgen Receptor Gene.* J Clin Endocrinol Metab. 2016 Jul 12;:jc20161372 Authors: Lucas-Herald A, Bertelloni S, Juul A, Bryce J, Jiang J, Rodie M, Sinnott R, Boroujerdi M, Lindhardt-Johansen M, Hiort O, Holterhus PM, Cools M, Guaragna-Filho G, Guerra-Junior G, Weintrob N, Hannema S, Drop S, Guran T, Darendeliler F, Nordenstrom A, Hughes IA, Acerini C, Tadokoro-Cuccaro R, Ahmed SF Abstract BACKGROUND: In boys with suspected Partial Androgen Insensitivity Syndrome (PAIS), systematic e... περισσότερα »
Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review.
*Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review.* Contact Dermatitis. 2016 Jul 11; Authors: Spencer A, Gazzani P, Thompson DA Abstract BACKGROUND: (Meth)acrylates are important causes of contact allergy and allergic contact disease, such as dermatitis and stomatitis, with new and emerging sources resulting in changing clinical presentations. OBJECTIVES: To identify the (meth)acrylates that most commonly cause allergic contact disease, highlight their usefulness for screening, and examine their relationship with occupational and clinical da... περισσότερα »
macrophage; +65 new citations
65 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *macrophage* These pubmed results were generated on 2016/07/13 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/29Di2TL
p62/SQSTM1- Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.
*p62/SQSTM1- Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.* FEBS Lett. 2016 Jul 12; Authors: Taniguchi K, Yamachika S, He F, Karin M Abstract p62/SQSTM1 is a multifunctional signaling hub and autophagy adaptor with many binding partners, which allow it to activate mTORC1-dependent nutrient sensing, NF-κB-mediated inflammatory responses and the NRF2-activated antioxidant defense. p62 recognizes polyubiquitin chains via its C-terminal domain and binds to LC3 via its LIR motif, thereby promoting the autophagic degradation of ubiquitinated cargos. ... περισσότερα »
The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes.
*The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes.* Dev Cell. 2016 Jul 11;38(1):86-99 Authors: Yamamoto H, Fujioka Y, Suzuki SW, Noshiro D, Suzuki H, Kondo-Kakuta C, Kimura Y, Hirano H, Ando T, Noda NN, Ohsumi Y Abstract Autophagosome formation in yeast entails starvation-induced assembly of the pre-autophagosomal structure (PAS), in which multiple Atg1 complexes (composed of Atg1, Atg13, and the Atg17-Atg29-Atg31 subcomplex) are initially engaged. However, the molecular mechanisms underlying the multimeric assembly of ... περισσότερα »
Loss-of-function mutations in the SIGMAR1 gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+ signaling.
*Loss-of-function mutations in the SIGMAR1 gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+ signaling.* Hum Mol Genet. 2016 Jul 8; Authors: Gregianin E, Pallafacchina G, Zanin S, Crippa V, Rusmini P, Poletti A, Fang M, Li Z, Diano L, Petrucci A, Lispi L, Cavallaro T, Fabrizi GM, Muglia M, Boaretto F, Vettori A, Rizzuto R, Mostacciuolo ML, Vazza G Abstract Distal Hereditary Motor Neuropathies (dHMNs) are clinically and genetically heterogeneous neurological conditions characterized by degeneration of the lower motor neurons. So far, 18 d... περισσότερα »
Accessory Interaction Motifs in the Atg19 Cargo Receptor Enable Strong Binding to the Clustered Ubiquitin-Related Atg8 Protein.
*Accessory Interaction Motifs in the Atg19 Cargo Receptor Enable Strong Binding to the Clustered Ubiquitin-Related Atg8 Protein.* J Biol Chem. 2016 Jul 11; Authors: Abert C, Kontaxis G, Martens S Abstract Selective autophagy contributes to cellular homeostasis by delivering harmful material into the lysosomal system for degradation via vesicular intermediates referred to as autophagosomes. The cytoplasm-to-vacuole-targeting pathway is a variant of selective autophagy in S. cerevisiae during which hydrolases such as prApe1 are transported into the vacuole. In general, selectivity ... περισσότερα »
Niemann Pick type C2 deficiency impairs autophagy-lysosomal activity, mitochondrial function, and TLR signaling in adipocytes.
*Niemann Pick type C2 deficiency impairs autophagy-lysosomal activity, mitochondrial function, and TLR signaling in adipocytes.* J Lipid Res. 2016 Jul 8; Authors: Guo H, Zhao M, Qiu X, Deis JA, Huang H, Tang QQ, Chen X Abstract In this study, we investigated the role and mechanism of NPC2 in regulating lysosomal activity, mitophagy, and mitochondrial function in adipocytes. We found that knocking down NPC2 impaired lysosomal activity, as evidenced by the reduced mature cathepsin B (CTSB), the increased accumulation of LC3 and p62, and the decreased autophagic flux. In NPC2-knockdo... περισσότερα »
Differential Regulation of Autophagy and Mitophagy in Pulmonary Diseases.
*Differential Regulation of Autophagy and Mitophagy in Pulmonary Diseases.* Am J Physiol Lung Cell Mol Physiol. 2016 Jul 8;:ajplung.00128.2016 Authors: Aggarwal S, Mannam P, Zhang J Abstract Lysosomal mediated degradation of intracellular lipids, proteins and organelles, known as autophagy, represents a inducible adaptive response to lung injury resulting from exposure to insults, such as hypoxia, microbes, inflammation, ischemia-reperfusion, pharmaceuticals (e.g. bleomycin), or inhaled xenobiotics (i.e., air pollution, cigarette smoke). This process clears damaged or toxic cellul... περισσότερα »
Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin.
*Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin.* Mol Cell Endocrinol. 2016 Jul 8; Authors: Letra-Vilela R, Sánchez-Sánchez AM, Rocha AM, Martin V, Branco-Santos J, Puente-Moncada N, Santa-Marta M, Outeiro TF, Antolín I, Rodriguez C, Herrera F Abstract Melatonin (N-acetyl-5-methoxytryptamine) is a highly pleiotropic hormone with antioxidant, antiproliferative, oncolytic and neuroprotective properties. Here, we present evidence that the N-acetyl side chain plays a key role in melatonin's antiproliferative effect in... περισσότερα »
Metformin targeting autophagy overcomes progesterone resistance in endometrial carcinoma.
*Metformin targeting autophagy overcomes progesterone resistance in endometrial carcinoma.* Arch Gynecol Obstet. 2016 Jul 11; Authors: Zhuo Z, Wang A, Yu H Abstract PURPOSE: Metformin is the most prescribed anti-diabetic medication worldwide because of its proven efficacy and limited side effects. In this study, the significant anticancer effect of metformin was investigated in both endometrial carcinoma and progesterone-resistant endometrial carcinoma cells. METHODS: We tested the growth inhibition assay using MTT cell proliferation, cell cycle assay, apoptosis assessment with f... περισσότερα »
Sirtuins as modifiers of Parkinson's disease pathology.
*Sirtuins as modifiers of Parkinson's disease pathology.* J Neurosci Res. 2016 Jul 12; Authors: Tang BL Abstract Parkinson's disease (PD) is the most common movement disorder associated with the elderly which, other than symptomatic therapies, has no effective treatment or preventive measures. Sirtuins and their pharmacological activators/inhibitors have been associated with a range of neuroprotective effects, and a large body of work on sirtuins' influence on PD pathology has accumulated over the past decade. Here, evidence for sirtuins' activities as modifiers of PD pathology a... περισσότερα »
The Role of MicroRNAs and Their Targets in Osteoarthritis.
*The Role of MicroRNAs and Their Targets in Osteoarthritis.* Curr Rheumatol Rep. 2016 Aug;18(8):56 Authors: Sondag GR, Haqqi TM Abstract Micro ribonucleic acid (microRNA) regulation and expression has become an emerging field in determining the mechanisms regulating a variety of inflammation-mediated diseases. Several studies have focused on specific microRNAs that are differentially expressed in cases of osteoarthritis. Furthermore, several targets of these miRNAs important in disease progression have also been identified. In this review, we focus on microRNA biogenesis, regulat... περισσότερα »
Pinus radiata bark extract induces caspase-independent apoptosis-like cell death in MCF-7 human breast cancer cells.
*Pinus radiata bark extract induces caspase-independent apoptosis-like cell death in MCF-7 human breast cancer cells.* Cell Biol Toxicol. 2016 Jul 12; Authors: Venkatesan T, Choi YW, Mun SP, Kim YK Abstract In the present study, we investigated the anticancer activity of Pinus radiata bark extract (PRE) against MCF-7 human breast cancer cells. First, we observed that PRE induces potent cytotoxic effects in MCF-7 cells. The cell death had features of cytoplasmic vacuolation, plasma membrane permeabilization, chromatin condensation, phosphatidylserine externalization, absence of ex... περισσότερα »
Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects.
*Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects.* Mol Psychiatry. 2016 Jul 12; Authors: Kim HJ, Cho MH, Shim WH, Kim JK, Jeon EY, Kim DH, Yoon SY Abstract Autism spectrum disorders (ASDs) are neurodevelopmental disorders caused by various genetic and environmental factors that result in synaptic abnormalities. ASD development is suggested to involve microglia, which have a role in synaptic refinement during development. Autophagy and related pathways are also suggested to be involved in ASDs. However, the precise roles of microglial... περισσότερα »
Autophagy Improves the Immunosuppression of CD4+ T Cells by Mesenchymal Stem Cells Through Transforming Growth Factor-β1.
*Autophagy Improves the Immunosuppression of CD4+ T Cells by Mesenchymal Stem Cells Through Transforming Growth Factor-β1.* Stem Cells Transl Med. 2016 Jul 11; Authors: Gao L, Cen S, Wang P, Xie Z, Liu Z, Deng W, Su H, Wu X, Wang S, Li J, Ouyang Y, Wu Y, Shen H Abstract : Mesenchymal stem cells (MSCs) have been extensively investigated as a promising approach to treat many autoimmune and inflammatory diseases. The stress condition would affect the therapeutic efficacy and induce autophagy of MSCs. However, whether autophagy would affect the immunosuppressive capacity of MSCs is l... περισσότερα »
Pericardial Tumor Presenting As Recurrent Pericardial Effusion--A Case Report.
Related Articles *Pericardial Tumor Presenting As Recurrent Pericardial Effusion--A Case Report.* Mymensingh Med J. 2016 Jan;25(1):182-5 Authors: Hasan MN, Rahman MF, Habib SA, Hossain SZ, Fatema N, Debnath RC Abstract Pericardial tumors are unusual and may be difficult to characterise with imaging. They manifest as large, non-contractile, solid masses within the pericardium. Presenting symptoms include heart failure, arrhythmias, sudden death, cyanosis and chest pain. But it can also present as recurrent pericardial effusion misdiagnosed as tuberculosis and other infectious cau... περισσότερα »
Retrospective inter- and intra-patient evaluation of trabectedin after best supportive care for patients with advanced translocation-related sarcoma after failure of standard chemotherapy.
[image: http:--linkinghub.elsevier.com-ihub-imag] [image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Retrospective inter- and intra-patient evaluation of trabectedin after best supportive care for patients with advanced translocation-related sarcoma after failure of standard chemotherapy.* Eur J Cancer. 2016 Mar;56:122-30 Authors: Araki N, Takahashi S, Sugiura H, Ueda T, Yonemoto T, Takahashi M, Morioka H, Hiraga H, Hiruma T, Kunisada T, Matsumine A, Kawai A Abstract AIM: Our randomised phase II study showed the clinical benefit of trabectedin compared with best ... περισσότερα »
Management and prognosis of malignant peripheral nerve sheath tumors: The experience of the French Sarcoma Group (GSF-GETO).
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Management and prognosis of malignant peripheral nerve sheath tumors: The experience of the French Sarcoma Group (GSF-GETO).* Eur J Cancer. 2016 Mar;56:77-84 Authors: Valentin T, Le Cesne A, Ray-Coquard I, Italiano A, Decanter G, Bompas E, Isambert N, Thariat J, Linassier C, Bertucci F, Bay JO, Bellesoeur A, Penel N, Le Guellec S, Filleron T, Chevreau C Abstract BACKGROUND: Malignant peripheral nerve sheath tumors (MPNST) are a rare subtype of soft tissue sarcoma. They can arise in irradiated fields, in patients ... περισσότερα »
Patellar Subluxation With Early-Phase Synovial Chondromatosis of the Knee.
[image: http:--5dbfc044f95dcfbf0e6a-199cf8a4b18a] Related Articles *Patellar Subluxation With Early-Phase Synovial Chondromatosis of the Knee.* Orthopedics. 2016 Jan-Feb;39(1):e176-9 Authors: Bashaireh KM Abstract Primary synovial chondromatosis is a rare, benign, monoarticular disease process that affects the synovial membrane of the joint, the synovial sheath, or the bursa around the joint. The etiology is unknown, but it has been associated with trauma in some cases. Although it is a benign lesion, if left untreated, it may lead to early secondary osteoarthritis of the joint. ... περισσότερα »
Intrapelvic Bulky Tumor as an Unusual Presentation of Erdheim-Chester Disease.
[image: http:--linkout.jstage.jst.go.jp-logo.gif] Related Articles *Intrapelvic Bulky Tumor as an Unusual Presentation of Erdheim-Chester Disease.* Intern Med. 2015;54(24):3241-5 Authors: Taguchi S, Kishida Y, Tamura K, Nose Y, Sato T, Ishikawa A, Homma Y, Yamakawa M Abstract Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis, which is known to affect various organs; however, there have been no reports of its intrapelvic involvement. We herein describe the case of 69-year-old man who died of a rapidly-growing intrapelvic tumor, which was finally di... περισσότερα »
Cardiac Papillary Fibroelastoma Originating from the Mitral Valve Chordae.
[image: http:--linkout.jstage.jst.go.jp-logo.gif] Related Articles *Cardiac Papillary Fibroelastoma Originating from the Mitral Valve Chordae.* Intern Med. 2015;54(24):3161-4 Authors: Kawamura I, Hayashi M, Kanamori H, Kawasaki M, Nishigaki K, Minatoguchi S, Mizuno Y, Takemura H Abstract Cardiac papillary fibroelastoma (CPF) is a rare benign primary cardiac neoplasm. In particular, CPF originating from the mitral valve chordae is extremely rare. A 74-year-old man was hospitalized for the evaluation of a cardiac mass in the left ventricle. Echocardiography revealed a mobile, spher... περισσότερα »
Orthotopic Esophageal Cancers: Intraesophageal Hyperthermia-enhanced Direct Chemotherapy in Rats.
*Orthotopic Esophageal Cancers: Intraesophageal Hyperthermia-enhanced Direct Chemotherapy in Rats.* Radiology. 2016 Jul 12;:152281 Authors: Shi Y, Zhang F, Bai Z, Wang J, Qiu L, Li Y, Meng Y, Valji K, Yang X Abstract Purpose To determine the feasibility of using intraesophageal radiofrequency (RF) hyperthermia to enhance local chemotherapy in a rat model with orthotopic esophageal squamous cancers. Materials and Methods The animal protocol was approved by the institutional animal care and use committee and the institutional review board. Human esophageal squamous cancer cells wer... περισσότερα »
Robotic Surgery for Upper GI Cancer: Current Status and Future Perspectives.
*Robotic Surgery for Upper GI Cancer: Current Status and Future Perspectives.* Dig Endosc. 2016 Jul 12; Authors: Suda K, Nakauchi M, Inaba K, Ishida Y, Uyama I Abstract Robotic surgery with the da Vinci Surgical System has been increasingly applied in a wide range of surgical specialties, especially in urology and gynecology; however, that in the field of upper GI tract has yet to be standard due to the lack of clear benefits in comparison with conventional minimally invasive surgery. We have been performing robotic gastrectomy and esophagectomy for operable patients with resecta... περισσότερα »
Factors associated with survival in patients with oesophageal cancer who achieve pathological complete response after chemoradiotherapy: a nationwide population-based study.
*Factors associated with survival in patients with oesophageal cancer who achieve pathological complete response after chemoradiotherapy: a nationwide population-based study.* Eur J Cardiothorac Surg. 2016 Jul 11; Authors: Chao YK, Chen HS, Wang BY, Hsu PK, Liu CC, Wu SC Abstract OBJECTIVES: Few data are currently available on the factors associated with survival in oesophageal cancer patients who achieve pathological complete response (pCR) after chemoradiotherapy (CRT). Using a nationwide database, we investigated the predictors of survival in this patient group. METHODS: Data w... περισσότερα »
Total minimally invasive esophagectomy for esophageal cancer: approaches and outcomes.
*Total minimally invasive esophagectomy for esophageal cancer: approaches and outcomes.* Langenbecks Arch Surg. 2016 Jul 11; Authors: Giugliano DN, Berger AC, Rosato EL, Palazzo F Abstract Since the introduction of minimally invasive esophagectomy 25 years ago, its use has been reported in several high volume centers. With only one published randomized control trial and five meta-analyses comparing its outcomes to open esophagectomy, available level I evidence is very limited. Available technical approaches include total minimally invasive transthoracic (Ivor Lewis or McKeown) or... περισσότερα »
Fast-track surgery improves postoperative clinical recovery and cellular and humoral immunity after esophagectomy for esophageal cancer.
*Fast-track surgery improves postoperative clinical recovery and cellular and humoral immunity after esophagectomy for esophageal cancer.* BMC Cancer. 2016;16:449 Authors: Chen L, Sun L, Lang Y, Wu J, Yao L, Ning J, Zhang J, Xu S Abstract BACKGROUND: Our aim was to investigate the influence of FTS on human cellular and humoral immunity using a randomized controlled clinical study in esophageal cancer patients. METHODS: Between October 2013 and December 2014, 276 patients with esophageal cancer in our department were enrolled in the study. The patients were randomized into two grou... περισσότερα »
Population attributable fraction of Esophageal squamous cell carcinoma due to smoking and alcohol in Uganda.
*Population attributable fraction of Esophageal squamous cell carcinoma due to smoking and alcohol in Uganda.* BMC Cancer. 2016;16:446 Authors: Okello S, Churchill C, Owori R, Nasasira B, Tumuhimbise C, Abonga CL, Mutiibwa D, Christiani DC, Corey KE Abstract BACKGROUND: Despite the high rates and regional variation of esophageal squamous cell carcinoma (ESCC) in East Africa, the contributions of smoking and alcohol to the ESCC burden in the general population are unknown. METHODS: We conducted a case-control study of patients presenting for upper gastrointestinal endoscopic examin... περισσότερα »
Short-term outcomes and one surgeon's learning curve for thoracoscopic esophagectomy performed with the patient in the prone position.
*Short-term outcomes and one surgeon's learning curve for thoracoscopic esophagectomy performed with the patient in the prone position.* Surg Today. 2016 Jul 11; Authors: Oshikiri T, Yasuda T, Hasegawa H, Yamamoto M, Kanaji S, Yamashita K, Matsuda T, Sumi Y, Nakamura T, Fujino Y, Tominaga M, Suzuki S, Kakeji Y Abstract PURPOSE: Thoracoscopic esophagectomy with the patient in the prone position (TEP) is now being performed as minimally invasive esophagectomy for esophageal cancer. This study examines the short-term outcomes and the learning curve associated with TEP. METHODS: One s... περισσότερα »
[The resection of the huge mediastinal schwannoma by the jugulal approach: one case report].
*[The resection of the huge mediastinal schwannoma by the jugulal approach: one case report].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Feb;30(4):329-30 Authors: Zhang Q, Lu G, Li D Abstract Neurogenic tumors located in the posterior mediastinum, generally require surgery which be confronted with greater risk,therefore, to design the best surgical approach and surgical methods is essential. A 67-year-old female patient had pharyngeal foreign body sensation and dysphagia. Thyroid ultrasound showed the right thyroid had a little nodule, and the left thyroid had a hypoec... περισσότερα »
Application of Gold Nanorods for Photothermal Therapy in Ex Vivo Human Oesophagogastric Adenocarcinoma.
[image: http:--images.ingentaselect.com-images-l] Related Articles *Application of Gold Nanorods for Photothermal Therapy in Ex Vivo Human Oesophagogastric Adenocarcinoma.* J Biomed Nanotechnol. 2016 Mar;12(3):481-90 Authors: Singh M, Harris-Birtill DC, Zhou Y, Gallina ME, Cass AE, Hanna GB, Elson DS Abstract Gold nanoparticles are chemically fabricated and tuned to strongly absorb near infrared (NIR) light, enabling deep optical penetration and therapy within human tissues, where sufficient heating induces tumour necrosis. In our studies we aim to establish the optimal gold nano... περισσότερα »
[Advances in molecular biology of esophageal squamous cell carcinoma].
[image: http:--journal.yiigle.com-r-cms-jiansuo-] Related Articles *[Advances in molecular biology of esophageal squamous cell carcinoma].* Zhonghua Bing Li Xue Za Zhi. 2016 Mar;45(3):209-12 Authors: Song Q, Jiang D, Hou Y PMID: 26956971 [PubMed - indexed for MEDLINE] from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/1UUVJuH via IFTTT
Discussion.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Discussion.* J Thorac Cardiovasc Surg. 2016 Mar;151(3):731-2 Authors: PMID: 26651963 [PubMed - indexed for MEDLINE] from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/29ORylE via IFTTT
Measuring quality of life after esophagectomy: Do we really need to go there?
[image: http:--linkinghub.elsevier.com-ihub-imag] *Measuring quality of life after esophagectomy: Do we really need to go there?* J Thorac Cardiovasc Surg. 2016 Mar;151(3):631-2 Authors: Kesler KA PMID: 26412314 [PubMed - indexed for MEDLINE] from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/29P5Q3d via IFTTT
Management of Esophageal Squamous Cell Carcinoma with Definitive Chemoradiotherapy in a Patient with Scleroderma: Case Report and Review of the Literature.
Related Articles *Management of Esophageal Squamous Cell Carcinoma with Definitive Chemoradiotherapy in a Patient with Scleroderma: Case Report and Review of the Literature.* J Gastrointest Cancer. 2012 Sep;43 Suppl 1:S156-60 Authors: Horowitz DP, Halmos B, Poneros J, Sonett J, Remotti H, Burri RJ PMID: 22585471 [PubMed - indexed for MEDLINE] from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/29P5eu3 via IFTTT
Synchronous Embryonal Rhabdomyosarcoma (NOS) of the Mid-oesophagus and Stomach.
Related Articles *Synchronous Embryonal Rhabdomyosarcoma (NOS) of the Mid-oesophagus and Stomach.* J Gastrointest Cancer. 2012 Sep;43 Suppl 1:S217-20 Authors: Gandhi JS, Pasricha S, Gupta G, Mahanta A, Mehta A, Doudagoudar C, Goswami V, Doval DC PMID: 22415320 [PubMed - indexed for MEDLINE] from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/29P5IAC via IFTTT
PDQ Cancer Information Summaries
*PDQ Cancer Information Summaries* Book. 2002 Authors: Abstract This PDQ cancer information summary has current information about the treatment of unusual cancers of childhood. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care. Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when t... περισσότερα »
Orthotopic Esophageal Cancers: Intraesophageal Hyperthermia-enhanced Direct Chemotherapy in Rats.
*Orthotopic Esophageal Cancers: Intraesophageal Hyperthermia-enhanced Direct Chemotherapy in Rats.* Radiology. 2016 Jul 12;:152281 Authors: Shi Y, Zhang F, Bai Z, Wang J, Qiu L, Li Y, Meng Y, Valji K, Yang X Abstract Purpose To determine the feasibility of using intraesophageal radiofrequency (RF) hyperthermia to enhance local chemotherapy in a rat model with orthotopic esophageal squamous cancers. Materials and Methods The animal protocol was approved by the institutional animal care and use committee and the institutional review board. Human esophageal squamous cancer cells wer... περισσότερα »
Robotic Surgery for Upper GI Cancer: Current Status and Future Perspectives.
*Robotic Surgery for Upper GI Cancer: Current Status and Future Perspectives.* Dig Endosc. 2016 Jul 12; Authors: Suda K, Nakauchi M, Inaba K, Ishida Y, Uyama I Abstract Robotic surgery with the da Vinci Surgical System has been increasingly applied in a wide range of surgical specialties, especially in urology and gynecology; however, that in the field of upper GI tract has yet to be standard due to the lack of clear benefits in comparison with conventional minimally invasive surgery. We have been performing robotic gastrectomy and esophagectomy for operable patients with resecta... περισσότερα »
Factors associated with survival in patients with oesophageal cancer who achieve pathological complete response after chemoradiotherapy: a nationwide population-based study.
*Factors associated with survival in patients with oesophageal cancer who achieve pathological complete response after chemoradiotherapy: a nationwide population-based study.* Eur J Cardiothorac Surg. 2016 Jul 11; Authors: Chao YK, Chen HS, Wang BY, Hsu PK, Liu CC, Wu SC Abstract OBJECTIVES: Few data are currently available on the factors associated with survival in oesophageal cancer patients who achieve pathological complete response (pCR) after chemoradiotherapy (CRT). Using a nationwide database, we investigated the predictors of survival in this patient group. METHODS: Data w... περισσότερα »
Total minimally invasive esophagectomy for esophageal cancer: approaches and outcomes.
*Total minimally invasive esophagectomy for esophageal cancer: approaches and outcomes.* Langenbecks Arch Surg. 2016 Jul 11; Authors: Giugliano DN, Berger AC, Rosato EL, Palazzo F Abstract Since the introduction of minimally invasive esophagectomy 25 years ago, its use has been reported in several high volume centers. With only one published randomized control trial and five meta-analyses comparing its outcomes to open esophagectomy, available level I evidence is very limited. Available technical approaches include total minimally invasive transthoracic (Ivor Lewis or McKeown) or... περισσότερα »
Fast-track surgery improves postoperative clinical recovery and cellular and humoral immunity after esophagectomy for esophageal cancer.
*Fast-track surgery improves postoperative clinical recovery and cellular and humoral immunity after esophagectomy for esophageal cancer.* BMC Cancer. 2016;16:449 Authors: Chen L, Sun L, Lang Y, Wu J, Yao L, Ning J, Zhang J, Xu S Abstract BACKGROUND: Our aim was to investigate the influence of FTS on human cellular and humoral immunity using a randomized controlled clinical study in esophageal cancer patients. METHODS: Between October 2013 and December 2014, 276 patients with esophageal cancer in our department were enrolled in the study. The patients were randomized into two grou... περισσότερα »
Population attributable fraction of Esophageal squamous cell carcinoma due to smoking and alcohol in Uganda.
*Population attributable fraction of Esophageal squamous cell carcinoma due to smoking and alcohol in Uganda.* BMC Cancer. 2016;16:446 Authors: Okello S, Churchill C, Owori R, Nasasira B, Tumuhimbise C, Abonga CL, Mutiibwa D, Christiani DC, Corey KE Abstract BACKGROUND: Despite the high rates and regional variation of esophageal squamous cell carcinoma (ESCC) in East Africa, the contributions of smoking and alcohol to the ESCC burden in the general population are unknown. METHODS: We conducted a case-control study of patients presenting for upper gastrointestinal endoscopic examin... περισσότερα »
Short-term outcomes and one surgeon's learning curve for thoracoscopic esophagectomy performed with the patient in the prone position.
*Short-term outcomes and one surgeon's learning curve for thoracoscopic esophagectomy performed with the patient in the prone position.* Surg Today. 2016 Jul 11; Authors: Oshikiri T, Yasuda T, Hasegawa H, Yamamoto M, Kanaji S, Yamashita K, Matsuda T, Sumi Y, Nakamura T, Fujino Y, Tominaga M, Suzuki S, Kakeji Y Abstract PURPOSE: Thoracoscopic esophagectomy with the patient in the prone position (TEP) is now being performed as minimally invasive esophagectomy for esophageal cancer. This study examines the short-term outcomes and the learning curve associated with TEP. METHODS: One s... περισσότερα »
[The resection of the huge mediastinal schwannoma by the jugulal approach: one case report].
*[The resection of the huge mediastinal schwannoma by the jugulal approach: one case report].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Feb;30(4):329-30 Authors: Zhang Q, Lu G, Li D Abstract Neurogenic tumors located in the posterior mediastinum, generally require surgery which be confronted with greater risk,therefore, to design the best surgical approach and surgical methods is essential. A 67-year-old female patient had pharyngeal foreign body sensation and dysphagia. Thyroid ultrasound showed the right thyroid had a little nodule, and the left thyroid had a hypoec... περισσότερα »
Application of Gold Nanorods for Photothermal Therapy in Ex Vivo Human Oesophagogastric Adenocarcinoma.
Related Articles *Application of Gold Nanorods for Photothermal Therapy in Ex Vivo Human Oesophagogastric Adenocarcinoma.* J Biomed Nanotechnol. 2016 Mar;12(3):481-90 Authors: Singh M, Harris-Birtill DC, Zhou Y, Gallina ME, Cass AE, Hanna GB, Elson DS Abstract Gold nanoparticles are chemically fabricated and tuned to strongly absorb near infrared (NIR) light, enabling deep optical penetration and therapy within human tissues, where sufficient heating induces tumour necrosis. In our studies we aim to establish the optimal gold nanorod (GNR) concentration and laser power for induc... περισσότερα »
[Advances in molecular biology of esophageal squamous cell carcinoma].
Related Articles *[Advances in molecular biology of esophageal squamous cell carcinoma].* Zhonghua Bing Li Xue Za Zhi. 2016 Mar;45(3):209-12 Authors: Song Q, Jiang D, Hou Y PMID: 26956971 [PubMed - indexed for MEDLINE] from pubmed: esophageal cancer http://ift.tt/1UUVJuH via IFTTT
Otosclerosis Associated with a De Novo Mutation -832G > A in the TGFB1 Gene Promoter Causing a Decreased Expression Level.
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
*Otosclerosis Associated with a De Novo Mutation -832G > A in the TGFB1 Gene Promoter Causing a Decreased Expression Level.* Sci Rep. 2016;6:29572 Authors: Priyadarshi S, Hansdah K, Ray CS, Biswal NC, Ramchander PV Abstract Otosclerosis (OTSC) is defined by abnormal bone remodeling in the otic capsule of middle ear which leads to conductive hearing loss. In our previous study, we have identified a de novo heterozygous mutation -832G > A in the promoter of TGFB1 in an otosclerosis patient. In the present study, we progressively screened this mutation in a cohort of 254 cases and 2... περισσότερα »
Study of Effect of Household Parental Smoking on Development of Acute Otitis Media in Children Under 12 Years.
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Study of Effect of Household Parental Smoking on Development of Acute Otitis Media in Children Under 12 Years.* Glob J Health Sci. 2016 May;8(5):81-8 Authors: Amani S, Yarmohammadi P Abstract BACKGROUND & AIM: High prevalence of acute otitis media (AOM) in children represents a combination of the factors developing eustachian tube dysfunction and higher susceptibility to upper respiratory tract infections in children. This disease is relatively prevalent in Iran and much cost is spent annually to treat it. This study investi... περισσότερα »
Effects of SLC22A1 Polymorphisms on Metformin-Induced Reductions in Adiposity and Metformin Pharmacokinetics in Obese Children with Insulin Resistance
[image: cover.gif?v=1&s=cf04ac26a9387c4e45e51322] Abstract Steady state population pharmacokinetics of a non-commercial immediate release metformin (hydrochloride) drug product were characterized in 28 severely obese children with insulin resistance. The concentration-time profiles with double peaks were well described by a one-compartment model with two absorption sites. Mean population apparent clearance (CL/F) was 68.1 L/hr and mean apparent volume of distribution (V/F) was 28.8 L. Body weight was a covariate of CL/F and V/F. Estimated glomerular filtration rate was a signific... περισσότερα »
No Increased Risk of Ketoconazole Toxicity in Drug-Drug Interaction Studies
Abstract On July 2013 the FDA released a safety announcement regarding the use of ketoconazole and its adverse drug reactions (ADR). The FDA report advised against the use ketoconazole tablets as a first line treatment for any fungal infections because of the risk of potentially serious drug-drug interactions, and liver and adrenal gland complications. The European Medicines Agency (EMA) also proposed to limit the use of oral ketoconazole in fungal infections due to the same risk of harmful effects and interactions. In addition, the FDA also advised against the use of oral ketocon... περισσότερα »
Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 21 δευτερόλεπτα
Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review. Contact Dermatitis. 2016 Jul 11; Authors: Spencer A, Gazzani P, Thompson DA Abstract BACKGROUND: (Meth)acrylates are important causes of contact allergy and allergic contact disease, such as dermatitis and stomatitis, with new and emerging sources resulting in changing clinical presentations. OBJECTIVES: To identify […]
Sex hormones and sleep in men and women from the general population: a cross-sectional observational study.
*Sex hormones and sleep in men and women from the general population: a cross-sectional observational study.* J Clin Endocrinol Metab. 2016 Jul 12;:jc20161832 Authors: Kische H, Ewert R, Fietze I, Gross S, Wallaschofski H, Völzke H, Dörr M, Nauck M, Obst A, Stubbe B, Penzel T, Haring R Abstract CONTEXT AND OBJECTIVES: Associations between sex hormones and sleep habits originate mainly from small and selected patient-based samples. We examined data from a population-based sample with various sleep characteristics and the major part of sex hormones measured by mass spectrometry. DES... περισσότερα »
A novel phenotype of familial hyperaldosteronism type III: Concurrence of aldosteronism and Cushing's syndrome.
*A novel phenotype of familial hyperaldosteronism type III: Concurrence of aldosteronism and Cushing's syndrome.* J Clin Endocrinol Metab. 2016 Jul 12;:jc20161504 Authors: Tong A, Liu G, Wang F, Jiang J, Yan Z, Zhang D, Zhang Y, Cai J Abstract CONTEXT: To date, all the familial hyperaldosteronism type III (FH-III) patients reported presented with typical primary aldosteronism (PA), without showing other adrenal hormone abnormalities. OBJECTIVE: This study characterized a novel phenotype of FH-III, and explored the possible pathogenesis. PATIENTS AND METHODS: A male patient presente... περισσότερα »
The Long Term Outcome Of Boys With Partial Androgen Insensitivity Syndrome And A Mutation In The Androgen Receptor Gene.
*The Long Term Outcome Of Boys With Partial Androgen Insensitivity Syndrome And A Mutation In The Androgen Receptor Gene.* J Clin Endocrinol Metab. 2016 Jul 12;:jc20161372 Authors: Lucas-Herald A, Bertelloni S, Juul A, Bryce J, Jiang J, Rodie M, Sinnott R, Boroujerdi M, Lindhardt-Johansen M, Hiort O, Holterhus PM, Cools M, Guaragna-Filho G, Guerra-Junior G, Weintrob N, Hannema S, Drop S, Guran T, Darendeliler F, Nordenstrom A, Hughes IA, Acerini C, Tadokoro-Cuccaro R, Ahmed SF Abstract BACKGROUND: In boys with suspected Partial Androgen Insensitivity Syndrome (PAIS), systematic e... περισσότερα »
Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review.
*Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review.* Contact Dermatitis. 2016 Jul 11; Authors: Spencer A, Gazzani P, Thompson DA Abstract BACKGROUND: (Meth)acrylates are important causes of contact allergy and allergic contact disease, such as dermatitis and stomatitis, with new and emerging sources resulting in changing clinical presentations. OBJECTIVES: To identify the (meth)acrylates that most commonly cause allergic contact disease, highlight their usefulness for screening, and examine their relationship with occupational and clinical da... περισσότερα »
macrophage; +65 new citations
65 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *macrophage* These pubmed results were generated on 2016/07/13 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/29Di2TL via IFTTT
[Clinical characteristics of 100 vestibular migraine cases].
*[Clinical characteristics of 100 vestibular migraine cases].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Mar;30(5):399-401 Authors: Chen J, Gong D, Cai S, Wu Z, Lin X, Ma X, Yu L Abstract OBJECTIVE: To analyze the characteristics of vestibular migraine (VM), in order to understand the auditory and vestibular function. METHOD: One hundred cases of confirmed or suspected VM patients were observed. Routine examination including pure tone test, vestibular dual temperature test and vestibular evoked myogenic potential(VEMP) and video head impulse test(v-HIT) Were conducted. R... περισσότερα »
Type 1 Hyperlipoproteinemia due to Compound Heterozygous Rare Variants in GCKR.
*Type 1 Hyperlipoproteinemia due to Compound Heterozygous Rare Variants in GCKR.* J Clin Endocrinol Metab. 2016 Jul 12;:jc20162179 Authors: Shetty S, Xing C, Garg A Abstract BACKGROUND: Type 1 hyperlipoproteinemia (T1HLP) is a rare, autosomal recessive disorder characterized by extreme elevations in serum triglyceride (TG) levels. Despite considerable progress in identifying several causal genes for T1HLP such as, LPL, APOC2, APOA5, LMF1 and GPIHBP1, the molecular basis of some extremely rare patients presenting with T1HLP remains obscure. CASE DESCRIPTION: We report a 58-year-ol... περισσότερα »
Sex hormones and sleep in men and women from the general population: a cross-sectional observational study.
*Sex hormones and sleep in men and women from the general population: a cross-sectional observational study.* J Clin Endocrinol Metab. 2016 Jul 12;:jc20161832 Authors: Kische H, Ewert R, Fietze I, Gross S, Wallaschofski H, Völzke H, Dörr M, Nauck M, Obst A, Stubbe B, Penzel T, Haring R Abstract CONTEXT AND OBJECTIVES: Associations between sex hormones and sleep habits originate mainly from small and selected patient-based samples. We examined data from a population-based sample with various sleep characteristics and the major part of sex hormones measured by mass spectrometry. DES... περισσότερα »
A novel phenotype of familial hyperaldosteronism type III: Concurrence of aldosteronism and Cushing's syndrome.
*A novel phenotype of familial hyperaldosteronism type III: Concurrence of aldosteronism and Cushing's syndrome.* J Clin Endocrinol Metab. 2016 Jul 12;:jc20161504 Authors: Tong A, Liu G, Wang F, Jiang J, Yan Z, Zhang D, Zhang Y, Cai J Abstract CONTEXT: To date, all the familial hyperaldosteronism type III (FH-III) patients reported presented with typical primary aldosteronism (PA), without showing other adrenal hormone abnormalities. OBJECTIVE: This study characterized a novel phenotype of FH-III, and explored the possible pathogenesis. PATIENTS AND METHODS: A male patient presente... περισσότερα »
The Long Term Outcome Of Boys With Partial Androgen Insensitivity Syndrome And A Mutation In The Androgen Receptor Gene.
*The Long Term Outcome Of Boys With Partial Androgen Insensitivity Syndrome And A Mutation In The Androgen Receptor Gene.* J Clin Endocrinol Metab. 2016 Jul 12;:jc20161372 Authors: Lucas-Herald A, Bertelloni S, Juul A, Bryce J, Jiang J, Rodie M, Sinnott R, Boroujerdi M, Lindhardt-Johansen M, Hiort O, Holterhus PM, Cools M, Guaragna-Filho G, Guerra-Junior G, Weintrob N, Hannema S, Drop S, Guran T, Darendeliler F, Nordenstrom A, Hughes IA, Acerini C, Tadokoro-Cuccaro R, Ahmed SF Abstract BACKGROUND: In boys with suspected Partial Androgen Insensitivity Syndrome (PAIS), systematic e... περισσότερα »
Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review.
*Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review.* Contact Dermatitis. 2016 Jul 11; Authors: Spencer A, Gazzani P, Thompson DA Abstract BACKGROUND: (Meth)acrylates are important causes of contact allergy and allergic contact disease, such as dermatitis and stomatitis, with new and emerging sources resulting in changing clinical presentations. OBJECTIVES: To identify the (meth)acrylates that most commonly cause allergic contact disease, highlight their usefulness for screening, and examine their relationship with occupational and clinical da... περισσότερα »
macrophage; +65 new citations
65 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *macrophage* These pubmed results were generated on 2016/07/13 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/29Di2TL
p62/SQSTM1- Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.
*p62/SQSTM1- Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.* FEBS Lett. 2016 Jul 12; Authors: Taniguchi K, Yamachika S, He F, Karin M Abstract p62/SQSTM1 is a multifunctional signaling hub and autophagy adaptor with many binding partners, which allow it to activate mTORC1-dependent nutrient sensing, NF-κB-mediated inflammatory responses and the NRF2-activated antioxidant defense. p62 recognizes polyubiquitin chains via its C-terminal domain and binds to LC3 via its LIR motif, thereby promoting the autophagic degradation of ubiquitinated cargos. ... περισσότερα »
The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes.
*The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes.* Dev Cell. 2016 Jul 11;38(1):86-99 Authors: Yamamoto H, Fujioka Y, Suzuki SW, Noshiro D, Suzuki H, Kondo-Kakuta C, Kimura Y, Hirano H, Ando T, Noda NN, Ohsumi Y Abstract Autophagosome formation in yeast entails starvation-induced assembly of the pre-autophagosomal structure (PAS), in which multiple Atg1 complexes (composed of Atg1, Atg13, and the Atg17-Atg29-Atg31 subcomplex) are initially engaged. However, the molecular mechanisms underlying the multimeric assembly of ... περισσότερα »
Loss-of-function mutations in the SIGMAR1 gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+ signaling.
*Loss-of-function mutations in the SIGMAR1 gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+ signaling.* Hum Mol Genet. 2016 Jul 8; Authors: Gregianin E, Pallafacchina G, Zanin S, Crippa V, Rusmini P, Poletti A, Fang M, Li Z, Diano L, Petrucci A, Lispi L, Cavallaro T, Fabrizi GM, Muglia M, Boaretto F, Vettori A, Rizzuto R, Mostacciuolo ML, Vazza G Abstract Distal Hereditary Motor Neuropathies (dHMNs) are clinically and genetically heterogeneous neurological conditions characterized by degeneration of the lower motor neurons. So far, 18 d... περισσότερα »
Accessory Interaction Motifs in the Atg19 Cargo Receptor Enable Strong Binding to the Clustered Ubiquitin-Related Atg8 Protein.
*Accessory Interaction Motifs in the Atg19 Cargo Receptor Enable Strong Binding to the Clustered Ubiquitin-Related Atg8 Protein.* J Biol Chem. 2016 Jul 11; Authors: Abert C, Kontaxis G, Martens S Abstract Selective autophagy contributes to cellular homeostasis by delivering harmful material into the lysosomal system for degradation via vesicular intermediates referred to as autophagosomes. The cytoplasm-to-vacuole-targeting pathway is a variant of selective autophagy in S. cerevisiae during which hydrolases such as prApe1 are transported into the vacuole. In general, selectivity ... περισσότερα »
Niemann Pick type C2 deficiency impairs autophagy-lysosomal activity, mitochondrial function, and TLR signaling in adipocytes.
*Niemann Pick type C2 deficiency impairs autophagy-lysosomal activity, mitochondrial function, and TLR signaling in adipocytes.* J Lipid Res. 2016 Jul 8; Authors: Guo H, Zhao M, Qiu X, Deis JA, Huang H, Tang QQ, Chen X Abstract In this study, we investigated the role and mechanism of NPC2 in regulating lysosomal activity, mitophagy, and mitochondrial function in adipocytes. We found that knocking down NPC2 impaired lysosomal activity, as evidenced by the reduced mature cathepsin B (CTSB), the increased accumulation of LC3 and p62, and the decreased autophagic flux. In NPC2-knockdo... περισσότερα »
Differential Regulation of Autophagy and Mitophagy in Pulmonary Diseases.
*Differential Regulation of Autophagy and Mitophagy in Pulmonary Diseases.* Am J Physiol Lung Cell Mol Physiol. 2016 Jul 8;:ajplung.00128.2016 Authors: Aggarwal S, Mannam P, Zhang J Abstract Lysosomal mediated degradation of intracellular lipids, proteins and organelles, known as autophagy, represents a inducible adaptive response to lung injury resulting from exposure to insults, such as hypoxia, microbes, inflammation, ischemia-reperfusion, pharmaceuticals (e.g. bleomycin), or inhaled xenobiotics (i.e., air pollution, cigarette smoke). This process clears damaged or toxic cellul... περισσότερα »
Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin.
*Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin.* Mol Cell Endocrinol. 2016 Jul 8; Authors: Letra-Vilela R, Sánchez-Sánchez AM, Rocha AM, Martin V, Branco-Santos J, Puente-Moncada N, Santa-Marta M, Outeiro TF, Antolín I, Rodriguez C, Herrera F Abstract Melatonin (N-acetyl-5-methoxytryptamine) is a highly pleiotropic hormone with antioxidant, antiproliferative, oncolytic and neuroprotective properties. Here, we present evidence that the N-acetyl side chain plays a key role in melatonin's antiproliferative effect in... περισσότερα »
Metformin targeting autophagy overcomes progesterone resistance in endometrial carcinoma.
*Metformin targeting autophagy overcomes progesterone resistance in endometrial carcinoma.* Arch Gynecol Obstet. 2016 Jul 11; Authors: Zhuo Z, Wang A, Yu H Abstract PURPOSE: Metformin is the most prescribed anti-diabetic medication worldwide because of its proven efficacy and limited side effects. In this study, the significant anticancer effect of metformin was investigated in both endometrial carcinoma and progesterone-resistant endometrial carcinoma cells. METHODS: We tested the growth inhibition assay using MTT cell proliferation, cell cycle assay, apoptosis assessment with f... περισσότερα »
Sirtuins as modifiers of Parkinson's disease pathology.
*Sirtuins as modifiers of Parkinson's disease pathology.* J Neurosci Res. 2016 Jul 12; Authors: Tang BL Abstract Parkinson's disease (PD) is the most common movement disorder associated with the elderly which, other than symptomatic therapies, has no effective treatment or preventive measures. Sirtuins and their pharmacological activators/inhibitors have been associated with a range of neuroprotective effects, and a large body of work on sirtuins' influence on PD pathology has accumulated over the past decade. Here, evidence for sirtuins' activities as modifiers of PD pathology a... περισσότερα »
The Role of MicroRNAs and Their Targets in Osteoarthritis.
*The Role of MicroRNAs and Their Targets in Osteoarthritis.* Curr Rheumatol Rep. 2016 Aug;18(8):56 Authors: Sondag GR, Haqqi TM Abstract Micro ribonucleic acid (microRNA) regulation and expression has become an emerging field in determining the mechanisms regulating a variety of inflammation-mediated diseases. Several studies have focused on specific microRNAs that are differentially expressed in cases of osteoarthritis. Furthermore, several targets of these miRNAs important in disease progression have also been identified. In this review, we focus on microRNA biogenesis, regulat... περισσότερα »
Pinus radiata bark extract induces caspase-independent apoptosis-like cell death in MCF-7 human breast cancer cells.
*Pinus radiata bark extract induces caspase-independent apoptosis-like cell death in MCF-7 human breast cancer cells.* Cell Biol Toxicol. 2016 Jul 12; Authors: Venkatesan T, Choi YW, Mun SP, Kim YK Abstract In the present study, we investigated the anticancer activity of Pinus radiata bark extract (PRE) against MCF-7 human breast cancer cells. First, we observed that PRE induces potent cytotoxic effects in MCF-7 cells. The cell death had features of cytoplasmic vacuolation, plasma membrane permeabilization, chromatin condensation, phosphatidylserine externalization, absence of ex... περισσότερα »
Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects.
*Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects.* Mol Psychiatry. 2016 Jul 12; Authors: Kim HJ, Cho MH, Shim WH, Kim JK, Jeon EY, Kim DH, Yoon SY Abstract Autism spectrum disorders (ASDs) are neurodevelopmental disorders caused by various genetic and environmental factors that result in synaptic abnormalities. ASD development is suggested to involve microglia, which have a role in synaptic refinement during development. Autophagy and related pathways are also suggested to be involved in ASDs. However, the precise roles of microglial... περισσότερα »
Autophagy Improves the Immunosuppression of CD4+ T Cells by Mesenchymal Stem Cells Through Transforming Growth Factor-β1.
*Autophagy Improves the Immunosuppression of CD4+ T Cells by Mesenchymal Stem Cells Through Transforming Growth Factor-β1.* Stem Cells Transl Med. 2016 Jul 11; Authors: Gao L, Cen S, Wang P, Xie Z, Liu Z, Deng W, Su H, Wu X, Wang S, Li J, Ouyang Y, Wu Y, Shen H Abstract : Mesenchymal stem cells (MSCs) have been extensively investigated as a promising approach to treat many autoimmune and inflammatory diseases. The stress condition would affect the therapeutic efficacy and induce autophagy of MSCs. However, whether autophagy would affect the immunosuppressive capacity of MSCs is l... περισσότερα »
[Clinical characteristics of 100 vestibular migraine cases].
*[Clinical characteristics of 100 vestibular migraine cases].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Mar;30(5):399-401 Authors: Chen J, Gong D, Cai S, Wu Z, Lin X, Ma X, Yu L Abstract OBJECTIVE: To analyze the characteristics of vestibular migraine (VM), in order to understand the auditory and vestibular function. METHOD: One hundred cases of confirmed or suspected VM patients were observed. Routine examination including pure tone test, vestibular dual temperature test and vestibular evoked myogenic potential(VEMP) and video head impulse test(v-HIT) Were conducted. R... περισσότερα »
The trajectory of Pediatric Otolaryngology.
*The trajectory of Pediatric Otolaryngology.* Int J Pediatr Otorhinolaryngol. 2016 Jul 2; Authors: Ruben RJ PMID: 27401025 [PubMed - as supplied by publisher] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/29vbwRG via IFTTT
Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review.
*Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review.* Contact Dermatitis. 2016 Jul 11; Authors: Spencer A, Gazzani P, Thompson DA Abstract BACKGROUND: (Meth)acrylates are important causes of contact allergy and allergic contact disease, such as dermatitis and stomatitis, with new and emerging sources resulting in changing clinical presentations. OBJECTIVES: To identify the (meth)acrylates that most commonly cause allergic contact disease, highlight their usefulness for screening, and examine their relationship with occupational and clinical da... περισσότερα »
The Journal of Medical Sciences
Alexandros G. SfakianakisστοMedical Articles from India and Jaypee Journals by Sfakianakis G. AlexandrosΠριν από 30 δευτερόλεπτα
Table of Contents 1. Editorial Editorial S Rangalakshmi v-viii Full Text PDF | Abstract |FREE 2. ORIGINAL RESEARCH A Clinical Audit of Quality Indicators in Anesthesia Practice Maya Nadakarni, Desi Prakruthi, Sahajananda H 47-51 Full Text PDF | Abstract | 10.5005/jp-journals-10045-0014 |FREE 3. ORIGINAL RESEARCH Effectiveness and Utilization Pattern of Cognitive Behavior Therapy of Anxiety Disorders: Evidence from a Psychiatry Clinic Sudhir Hebbar 52-54 Full Text PDF | Abstract | 10.5005/jp-journals-10045-0015 |FREE 4. CASE REPORT Erdheim–Chester Disease Mamatha Patil, Dee... περισσότερα »
Malignancy in Solitary Thyroid Nodule.
Related Articles *Malignancy in Solitary Thyroid Nodule.* Mymensingh Med J. 2016 Jan;25(1):39-44 Authors: Majumder KR, Karmakar R, Karim SS, Al-Mamun A Abstract This prospective study was done to find out the relative frequency of the malignancy in cold solitary thyroid nodules with other solitary thyroid nodules (hot and warm). This study was carried out in the Department of General Surgery and Otolaryngology-Head & Neck Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from January 2011 to February 2012. One hundred (100) patients with clinically a... περισσότερα »
[Analysis of risk factors for bleeding after thyroid surgery].
Related Articles *[Analysis of risk factors for bleeding after thyroid surgery].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;51(1):63-7 Authors: Qiu X, Li Z, Liu J, An C, Yin Y, Tang P, Xu Z Abstract OBJECTIVE: To identify risk factors for bleeding after thyroid surgery, and discuss the potential relevance between the bleeding timing and sources. METHODS: A total of 2568 cases that underwent thyroid operation from June 2012 to June 2013 were collected and analysed retrospectively the risk factors for postoperative bleeding by Cox and the potential relevance between th... περισσότερα »
[Thyroid nodules – how to proceed?].
Related Articles *[Thyroid nodules – how to proceed?].* Ther Umsch. 2016;73(4):197-202 Authors: Murer K, Müller W Abstract Asymptomatic thyroid nodules are very common and detected with increasing frequency by radiological investigations of the neck as so-called "incidentalomas". If a thyroid nodule is found, the question arises how to proceed with this case. The goal is to recognize the very rare malignant nodules and to perform an adequate therapy. Every work-up of a thyroid nodule includes functional evaluation by determination of thyroid stimulating hormone (TSH). Is the lev... περισσότερα »
Malignancy in Solitary Thyroid Nodule.
Related Articles *Malignancy in Solitary Thyroid Nodule.* Mymensingh Med J. 2016 Jan;25(1):39-44 Authors: Majumder KR, Karmakar R, Karim SS, Al-Mamun A Abstract This prospective study was done to find out the relative frequency of the malignancy in cold solitary thyroid nodules with other solitary thyroid nodules (hot and warm). This study was carried out in the Department of General Surgery and Otolaryngology-Head & Neck Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from January 2011 to February 2012. One hundred (100) patients with clinically a... περισσότερα »
[Analysis of risk factors for bleeding after thyroid surgery].
Related Articles *[Analysis of risk factors for bleeding after thyroid surgery].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jan;51(1):63-7 Authors: Qiu X, Li Z, Liu J, An C, Yin Y, Tang P, Xu Z Abstract OBJECTIVE: To identify risk factors for bleeding after thyroid surgery, and discuss the potential relevance between the bleeding timing and sources. METHODS: A total of 2568 cases that underwent thyroid operation from June 2012 to June 2013 were collected and analysed retrospectively the risk factors for postoperative bleeding by Cox and the potential relevance between th... περισσότερα »
Electrocatalytic oxidation of phenol from wastewater using Ti/SnO 2 –Sb 2 O 4 electrode: chemical reaction pathway study
Abstract In this study, a titanium plate was impregnated with SnO2 and Sb (Ti/SnO2–Sb 2O4) for the electrocatalytic removal of phenol from wastewater, and the chemical degradation pathway was presented. The effects of various parameters such as pH, current density, supporting electrolyte, and initial phenol concentration were studied. At optimum conditions, it was found that phenol was quickly oxidized into benzoquinone because of the formation of various strong radicals during electrolysis by the Ti/SnO2–Sb2O4 anode from 100 to <1 mg/L over 1 h. The results of GC/MS analysis showed... περισσότερα »
Effect of cadmium accumulation on mineral nutrient levels in vegetable crops: potential implications for human health
Abstract Consumption of vegetables is often the predominant route whereby humans are exposed to the toxic metal Cd. Health impacts arising from Cd consumption may be influenced by changes in the mineral nutrient content of vegetables, which may occur when plants are exposed to Cd. Here, we subjected model root (carrot) and leaf (lettuce) vegetables to soil Cd concentrations of 0.3, 1.5, 3.3, and 9.6 μg g−1 for 10 weeks to investigate the effect of Cd exposure on Cd accumulation, growth performance, and mineral nutrient homeostasis. The findings demonstrated that Cd accumulation in ... περισσότερα »
In situ remediation of ortho -nitrochlorobenzene in soil by dual oxidants (hydrogen peroxide/persulfate)
Abstract The efficacies of catalyzed H2O2, activated persulfate, and catalyzed H2O2-persulfate processes for the degradation of *ortho*-nitrochlorobenzene (*o*-NCB) in soil were investigated. The application of catalyzed H2O2-persulfate process was promising, and after a careful adjustment of oxidants and activator doses, it demonstrated a considerable improvement in *o*-NCB degradation compared with activated persulfate process and catalyzed H2O2 process. The degradation of *o*-NCB in catalyzed H2O2-persulfate process was obviously influenced by the concentration of persulfate and... περισσότερα »
Disodium N,N-bis-(dithiocarboxy)ethanediamine: synthesis, performance, and mechanism of action toward trace ethylenediaminetetraacetic acid copper (II)
Abstract A new effective multi-dithiocarbamate heavy metal precipitant, disodium N,N-bis-(dithiocarboxy) ethanediamine (BDE), was synthesized by mixing ethanediamine with carbon disulfide under alkaline conditions, and it was utilized for removing trace ethylenediaminetetraacetic acid copper (II) (EDTA-Cu) from wastewater. Its structure was confirmed by ultraviolet spectra, Fourier transform infrared spectra, scanning electron microscopy, thermogravimetric analysis, and elemental analysis. The removal performance of EDTA-Cu by BDE was evaluated according to BDE dosage, initial con... περισσότερα »
Scale-up of electrolytic and photoelectrolytic processes for water reclaiming: a preliminary study
Abstract This work focuses on the scale-up of electrochemical and photoelectrochemical oxidation processes with diamond anodes for the removal of organic pollutants and disinfection of treated urban wastewater, two of the most important parameters for the reclaiming of wastewater. The removal of organics was studied with actual biologically treated urban wastewater intensified with 100 mg dm−3 of caffeine, added as a trace organic pollutant. The disinfection was also studied with biologically treated urban wastewater, and *Escherichia coli* was used to monitor the efficiency of th... περισσότερα »
A fatal yellow fever virus infection in China: description and lessons
[image: emi201689f2th.jpg] *A fatal yellow fever virus infection in China: description and lessons* Emerging Microbes & Infections 5, e69 (July 2016). doi:10.1038/emi.2016.89 Authors: Zhihai Chen, Lin Liu, Yanning Lv, Wei Zhang, Jiandong Li, Yi Zhang, Tian Di, Shuo Zhang, Jingyuan Liu, Jie Li, Jing Qu, Wenhao Hua, Chuan Li, Peng Wang, Quanfu Zhang, Yanli Xu, Rongmeng Jiang, Qin Wang, Lijuan Chen, Shiwen Wang, Xinghuo Pang, Mifang Liang, Xuejun Ma, Xingwang Li, Quanyi Wang, Fujie Zhang & Dexin Li from Infection via ola Kala on Inoreader http://ift.tt/29DgqsS via IFTTT
Management of Esophageal Squamous Cell Carcinoma with Definitive Chemoradiotherapy in a Patient with Scleroderma: Case Report and Review of the Literature.
Related Articles *Management of Esophageal Squamous Cell Carcinoma with Definitive Chemoradiotherapy in a Patient with Scleroderma: Case Report and Review of the Literature.* J Gastrointest Cancer. 2012 Sep;43 Suppl 1:S156-60 Authors: Horowitz DP, Halmos B, Poneros J, Sonett J, Remotti H, Burri RJ PMID: 22585471 [PubMed - indexed for MEDLINE] from pubmed: esophageal cancer http://ift.tt/29P5eu3 via IFTTT
Synchronous Embryonal Rhabdomyosarcoma (NOS) of the Mid-oesophagus and Stomach.
Related Articles *Synchronous Embryonal Rhabdomyosarcoma (NOS) of the Mid-oesophagus and Stomach.* J Gastrointest Cancer. 2012 Sep;43 Suppl 1:S217-20 Authors: Gandhi JS, Pasricha S, Gupta G, Mahanta A, Mehta A, Doudagoudar C, Goswami V, Doval DC PMID: 22415320 [PubMed - indexed for MEDLINE] from pubmed: esophageal cancer http://ift.tt/29P5IAC via IFTTT
PDQ Cancer Information Summaries
*PDQ Cancer Information Summaries* Book. 2002 Authors: Abstract This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of unusual cancers of childhood. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions. This summary is reviewed regularly and updated as necessary by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of the National Ca... περισσότερα »
PDQ Cancer Information Summaries
*PDQ Cancer Information Summaries* Book. 2002 Authors: Abstract This PDQ cancer information summary has current information about the treatment of unusual cancers of childhood. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care. Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when t... περισσότερα »
Continuous plasma perfusion of dual cartridges in series: rationale and early clinical experience
Abstract To improve the efficiency of plasma perfusion on eliminating plasma paraquat (PQ), we designed continuous plasma perfusion of dual cartridges in series (CPPDCS) on Diapact Braun CRRT machine. The goals of this study were to evaluate the effective of CPPDCS on paraquat removal in patients with acute paraquat intoxication. Our results show that the PQ clearance rate of dual cartridges was significantly higher than that of single cartridge at 1st, 2nd, 3rd, and 4th plasma perfusion. Compared with single-cartridge plasma perfusion, CPPDCS significantly reduced the frequency o... περισσότερα »
Multiple Reactivity of SnII Complexes Bearing Catecholate and o-Amidophenolate Ligands
The reactivity of tin(II) catecholate complex CatSn (*1*) (where Cat = 3,6-di-*tert*-butylcatecholate dianion) and two *o*-amidophenolate complexes DippAPSn (*2*) and PhAPSn (*3*) [where DippAP = 4,6-di-*tert* -butyl-*N*-(2,6-diisopropylphenyl)amidophenolate; PhAP = 4,6-di-*tert* -butyl-*N*-(phenyl)amidophenolate dianions] towards different reagents is reported. Products of the insertion of *1* and *2* into the S–S bond of tetramethylthiuram disulfide were obtained and characterised by X-ray diffraction analyses. The low temperature oxidation of complexes *1* and *2* with 2-ethoxy-... περισσότερα »
Amino Acid Ligands for Ruthenium(II)-Catalyzed C–H Arylation of Aryltetrazoles with Chlorides: Expedient Access to Antihypertension Drugs
Versatile ruthenium(II) complexes derived from amino acids enabled the first general C–H arylations of aryltetrazoles with inexpensive aryl chlorides. The user-friendly Piv-Val-OH-based ruthenium(II) catalyst was characterized by a broad substrate scope, excellent functional group tolerance, and high catalytic activity. Thereby, the ruthenium(II) catalysis set the stage for the step-economical preparation of the blockbuster antihypertension drug Valsartan, while displaying unique robustness in the C–H arylation regime. [image: Thumbnail image of graphical abstract] Ruthenium(II)... περισσότερα »
Copper(II) Trifluoromethanesulfonate Catalyzed Hydroamination Cyclization–Dimerization Cascade Reaction of Homopropargylic Amines for the Construction of Complex Fused Nitrogen-Containing Tetracycles
A Cu(OTf)2-catalyzed cascade cyclization reaction of simple homopropargylic amines was developed. The sequence involved an intramolecular radical hydroamination cyclization followed by dimerization by a Povarov-type reaction. Through this cascade reaction, a complex nitrogen-containing tetracycle framework was constructed in one pot with the formation of four new bonds and five stereocenters. Noteworthy, the aglycon of the natural product incargranine B was facilely and efficiently synthesized by using this method. [image: Thumbnail image of graphical abstract] A Cu(OTf)2-cataly... περισσότερα »
NaNO2/I2-Mediated Regioselective Synthesis of Nitrosoimidazoheterocycles from Acetophenones by a Domino Process
A regioselective synthesis of nitrosoimidazoheterocycles from the reaction of 2-aminopyridines and acetophenones in the presence of NaNO2 and I2 is described. The reaction is suggested to proceed by a domino process involving sequential imine formation, iodination, iodide displacement by the nitro group, and finally intramolecular cyclization. Reaction of these 3-nitrosoimidazo[1,2-*a*]pyridines with aldehydes in the presence of Fe/AcOH furnished 5-substituted pyrido[2′,1′:2,3]imidazo[4,5-*c*]isoquinolines by reduction of the nitroso group followed by a Pictet–Spengler reaction in... περισσότερα »
Ring-Rearrangement-Metathesis Approach to Polycycles: Substrate-Controlled Stereochemical Outcome During Grignard Addition
A variety of structurally intricate polycycles have been assembled through ruthenium-catalysed ring-rearrangement metathesis of norbornene derivatives. The various substrates required for this work were prepared using Diels–Alder reactions and Grignard additions as key steps. Enyne ring-rearrangement metathesis of a norbornene system containing a propargyl moiety produced a 1,3-diene; this was then treated with an appropriate dienophile to deliver the corresponding cycloaddition product. [image: Thumbnail image of graphical abstract] We have observed substrate-controlled selectiv... περισσότερα »
Fmoc solid-phase synthesis of C-terminal modified peptides by formation of a backbone cyclic urethane moiety
[image: GA?id=C6CC04245G] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC04245G, Communication Hader E. Elashal, Ryan D. Cohen, Monika Raj A universal strategy for solid phase synthesis of various C-terminal modified peptides independent of type of resins, unnatural linkers, and handles is developed. Semi-permanent protection at the C-termini of peptides is also afforded by the method described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via x... περισσότερα »
Amino Acid Ligands for Ruthenium(II)-Catalyzed C–H Arylation of Aryltetrazoles with Chlorides: Expedi ent Access to Antihypertension Drugs
Versatile ruthenium(II) complexes derived from amino acids enabled the first general C–H arylations of aryltetrazoles with inexpensive aryl chlorides. The user-friendly Piv-Val-OH-based ruthenium(II) catalyst was characterized by a broad substrate scope, excellent functional group tolerance, and high catalytic activity. Thereby, the ruthenium(II) catalysis set the stage for the step-economical preparation of the blockbuster antihypertension drug… Continue reading Amino Acid Ligands for Ruthenium(II)-Catalyzed C–H Arylation of Aryltetrazoles with Chlorides: Expedi ent Access to Antih... περισσότερα »
Copper(II) Trifluoromethanesulfonate Catalyzed Hydroamination Cyclization–Dimerization Cascade Reaction of Homopropargylic Amines for the Construction of Complex Fused Nitrogen-Containing Tetracycles
A Cu(OTf)2-catalyzed cascade cyclization reaction of simple homopropargylic amines was developed. The sequence involved an intramolecular radical hydroamination cyclization followed by dimerization by a Povarov-type reaction. Through this cascade reaction, a complex nitrogen-containing tetracycle framework was constructed in one pot with the formation of four new bonds and five stereocenters. Noteworthy, the aglycon of the… Continue reading Copper(II) Trifluoromethanesulfonate Catalyzed Hydroamination Cyclization–Dimerization Cascade Reaction of Homopropargylic Amines for the Constr... περισσότερα »
NaNO2/I2-Mediated Regioselective Synthesis of Nitrosoimidazoheterocycles from Acetophenones by a Domino Process
A regioselective synthesis of nitrosoimidazoheterocycles from the reaction of 2-aminopyridines and acetophenones in the presence of NaNO2 and I2 is described. The reaction is suggested to proceed by a domino process involving sequential imine formation, iodination, iodide displacement by the nitro group, and finally intramolecular cyclization. Reaction of these 3-nitrosoimidazo[1,2-a]pyridines with aldehydes in the presence… Continue reading NaNO2/I2-Mediated Regioselective Synthesis of Nitrosoimidazoheterocycles from Acetophenones by a Domino Process
Ring-Rearrangement-Metathesis Approach to Polycycles: Substrate-Controlled Stereochemical Outcome During Grignard Addition
A variety of structurally intricate polycycles have been assembled through ruthenium-catalysed ring-rearrangement metathesis of norbornene derivatives. The various substrates required for this work were prepared using Diels–Alder reactions and Grignard additions as key steps. Enyne ring-rearrangement metathesis of a norbornene system containing a propargyl moiety produced a 1,3-diene; this was then treated with an appropriate… Continue reading Ring-Rearrangement-Metathesis Approach to Polycycles: Substrate-Controlled Stereochemical Outcome During Grignard Addition
Fmoc solid-phase synthesis of C-terminal modified peptides by formation of a backbone cyclic urethane moiety
Chem. Commun., 2016, Advance Article DOI: 10.1039/C6CC04245G, Communication Hader E. Elashal, Ryan D. Cohen, Monika Raj A universal strategy for solid phase synthesis of various C-terminal modified peptides independent of type of resins, unnatural linkers, and handles is developed. Semi-permanent protection at the C-termini of peptides is also afforded by the method described. To cite… Continue reading Fmoc solid-phase synthesis of C-terminal modified peptides by formation of a backbone cyclic urethane moiety
Villous Adenoma Arising at the Hepaticojejunostomy Site (HJ Site): First Report of an Unusual Case
http://ift.tt/29IgqK2 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29D2qyd via IFTTT
Torsional strength of computer-aided design/computer-aided manufacturing–fabricated esthetic orthodontic brackets
The Angle Orthodontist, Ahead of Print. http://ift.tt/29OC80V from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29N5gE8 via IFTTT
Marginal bone loss around implants with platform-switched Morse-cone connection: a radiographic cross-sectional study
Abstract Objectives The aims of the present cross-sectional study are to evaluate the bone remodeling around Morse-cone implants placed subcrestally 1 year after loading and the prevalence of bone loss >0.5 mm after at least 3 years of loading. Material and methods Subjects who underwent a radiographic check in 2013 with implants that had been… Continue reading Marginal bone loss around implants with platform-switched Morse-cone connection: a radiographic cross-sectional study
Marginal bone loss around implants with platform-switched Morse-cone connection: a radiographic cross-sectional study
Abstract Objectives The aims of the present cross-sectional study are to evaluate the bone remodeling around Morse-cone implants placed subcrestally 1 year after loading and the prevalence of bone loss >0.5 mm after at least 3 years of loading. Material and methods Subjects who underwent a radiographic check in 2013 with implants that had been… Continue reading Marginal bone loss around implants with platform-switched Morse-cone connection: a radiographic cross-sectional study
Design of TRUST, a non-interventional, multicenter, 3-year prospective study investigating an integrated patient management approach in patients with relapsing-remitting multiple sclerosis treated with natalizumab
Natalizumab provides rapid and high-efficacy control of multiple sclerosis disease activity with long-term stabilization. However, the benefits of the drug are countered by a risk of developing progressive mul… from Neurology via xlomafota13 on Inoreader http://ift.tt/2a8tdUk via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29xF78E via IFTTT
Radical Prostatectomy Findings in White Hispanic/Latino Men With NCCN Very Low-risk Prostate Cancer Detected by Template Biopsy
[image: image]Radical prostatectomy (RP) outcomes have been studied in White and Black non-Hispanic men qualifying for Epstein active surveillance criteria (EASC). Herein, we first analyzed such outcomes in White Hispanic men. We studied 70 men with nonpalpable Gleason score 3+3=6 (Grade Group [GG] 1) prostate cancer (PCa) with ≤2 positive cores on biopsy who underwent RP. In 18 men, prostate-specific antigen (PSA) density (PSAD) was & gt;0.15 ng/mL/g. Three of these had insignificant and 15 had significant PCa. The remaining 52 men qualified for EASC. One patient had no PCa identified ... περισσότερα »
Reflex Estrogen Receptor (ER) and Progesterone Receptor (PR) Analysis of Ductal Carcinoma In Situ (DCIS) in Breast Needle Core Biopsy Specimens: An Unnecessary Exercise That Costs the United States $35 Million/y
[image: image]Most institutions reflexively test all breast core needle biopsy specimens showing ductal carcinoma in situ (DCIS) for estrogen receptor (ER) and progesterone receptor (PR). However, 5 factors suggest that this reflex testing unnecessarily increases costs. First, ER/PR results do not currently impact the next step in standard therapy; namely, surgical excision. Second, a subset of surgical excisions performed for DCIS diagnosed on core needle biopsy will harbor infiltrating mammary carcinoma, which will then need to be retested for ER/PR. Third, because ER and PR label... περισσότερα »
Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney
[image: image]Soft tissue undifferentiated round cell sarcoma (URCS) occurring in infants is a heterogenous group of tumors, often lacking known genetic abnormalities. On the basis of a t(10;17;14) karyotype in a pelvic URCS of a 4-month-old boy showing similar breakpoints with clear cell sarcoma of kidney (CCSK), we have investigated the possibility of shared genetic abnormalities in CCSK and soft tissue URCS. Most CCSKs are characterized by BCOR exon 16 internal tandem duplications (ITDs), whereas a smaller subset shows YWHAE-NUTM2B/E fusions. Because of overlapping clinicopatholo... περισσότερα »
Do Ancillary Studies Aid Detection and Classification of Barrett Esophagus?
[image: image]Barrett esophagus is a preneoplastic condition defined by the presence of intestinal metaplasia (ie, goblet cells) in an endoscopically apparent columnar-lined esophagus. Dysplasia is the most important risk factor for cancer development among patients with Barrett esophagus; approximately 6% of patients with high-grade dysplasia progress to adenocarcinoma within 1 year. Surgical pathologists are generally expected to address 2 clinical concerns when evaluating mucosal biopsy samples from patients with suspected Barrett esophagus; they should note the presence, or abse... περισσότερα »
Distinct Clinicopathologic and Genetic Features of 2 Histologic Subtypes of Intrahepatic Cholangiocarcinoma
[image: image]Previous studies have identified 2 clinically significant morphologic subtypes of intrahepatic cholangiocarcinoma (ICC) on the basis of anatomic location and/or histologic appearances. Recognizing that these classification schemes are not always applicable practically, this study aimed to establish a novel classification system based on mucin productivity and immunophenotype and to determine the rationale of this classification by examining the clinicopathologic and genetic characteristics of the 2 subtypes defined by this method. We retrospectively investigated 102 co... περισσότερα »
Pure Apocrine Carcinomas Represent a Clinicopathologically Distinct Androgen Receptor–Positive Subset of Triple-Negative Breast Cancers
[image: image]Apocrine carcinomas comprise ∼1% of all breast cancers and are characterized by large cells bearing abundant eosinophilic granular cytoplasm, round nuclei, and prominent nucleoli. They are typically estrogen receptor/progesterone receptor/HER2 negative, making them unresponsive to typical hormonal or HER2-based chemotherapy. However, this subtype of triple-negative breast cancers expresses androgen receptor (AR), a feature not shared by most nonapocrine triple-negative cancers (NA-TNCs). AR therefore represents a potential diagnostic tool and therapeutic target for apo... περισσότερα »
Analysis of NAB2-STAT6 Gene Fusion in 17 Cases of Meningeal Solitary Fibrous Tumor/Hemangiopericytoma: Review of the Literature
[image: image]Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a mesenchymal tumor that can affect virtually any region of the body. SFT/HPC of the thoracic cavity and soft tissue has been histologically considered a single biological entity termed SFT; in fact, NAB2-STAT6 gene fusion was recently identified in both diseases. In contrast, meningeal SFT and HPC still need to be investigated in detail with regard to gene fusion variants. The aim of this study was to verify the frequency of NAB2-STAT6 fusion and the relationship between fusion variants and clinicopathologic findi... περισσότερα »
Distinctive Patterns of CTNNB1 (β-Catenin) Alterations in Salivary Gland Basal Cell Adenoma and Basal Cell Adenocarcinoma
[image: image]Salivary gland basaloid neoplasms are diagnostically challenging. Limited publications report that some basal cell adenomas harbor CTNNB1 mutations, and nuclear β-catenin expression is prevalent. We evaluated β-catenin expression in basal cell adenomas and adenocarcinomas in comparison with salivary tumors in the differential diagnosis and performed targeted genetic analysis on a subset of cases. β-catenin immunohistochemistry was performed on formalin-fixed, paraffin-embedded whole sections from 73 tumors. Nuclear staining was scored semiquantitatively by extent and i... περισσότερα »
Clinicopathologic Analysis of Angioimmunoblastic T-cell Lymphoma With or Without RHOA G17V Mutation Using Formalin-fixed Paraffin-embedded Sections
[image: image]Angioimmunoblastic T-cell lymphoma (AITL) is an infrequent subtype of peripheral T-cell lymphoma derived from follicular helper T cells. Recently, a somatic G17V RHOA gene mutation has been reported. In this article, we examined the RHOA G17V mutation in 18 cases of AITL by 3 different techniques of Sanger sequencing, fully automated SNP genotyping, and deep sequencing, using routine diagnostic formalin-fixed paraffin-embedded tissue. The RHOA G17V mutation was detected in 10 cases (56%). Among the 10 mutated cases, 8 cases were detected by all 3 methods. The status of... περισσότερα »
Anastomosing Hemangiomas Arising in Unusual Locations: A Clinicopathologic Study of 17 Soft Tissue Cases Showing a Predilection for the Paraspinal Region
[image: image]Anastomosing hemangioma, a recently recognized benign vascular neoplasm originally described in the kidney, may be confused with well-differentiated angiosarcoma. Rare cases of anastomosing hemangiomas have been described in the liver and in nonrenal genitourinary sites. We report a series of 17 anastomosing hemangiomas occurring in unusual locations, in particular in the paravertebral soft tissues. The 17 tumors occurred in 10 male and 6 female patients, ranging in age from 2 to 85 years. One patient had bilateral, synchronous tumors involving the right paracaval and ... περισσότερα »
ETV6-NTRK3 Is Expressed in a Subset of ALK-Negative Inflammatory Myofibroblastic Tumors
[image: image]Inflammatory myofibroblastic tumor (IMT) is a genetically heterogenous tumor of the viscera and soft tissues, with multiple molecular features having been demonstrated in this tumor type. About 50% of cases harbor an anaplastic lymphoma kinase (ALK) gene rearrangement, and recent studies have described novel fusions involving the ROS1 and PDGFRβ genes in a subset of ALK-negative cases. However, the molecular features of the remaining subset of cases are not yet defined. We report a case of a large, highly aggressive IMT of the lung in a 17-year-old girl. This case was ... περισσότερα »
Interlaboratory Variability in the Histologic Grading of Colorectal Adenocarcinomas in a Nationwide Cohort
[image: image]Differentiation grade of colorectal adenocarcinoma (CRC) is a prognostic factor and important for therapy selection. In patients with stage II colon cancer, poor differentiation is an indication for adjuvant chemotherapy. The variability in daily practice in the grading of CRC was assessed in a nationwide cohort. Using the Dutch Pathology Registry (PALGA), all synoptically reported CRC resections from 2010 to 2013 were identified. Proportions of poorly differentiated (PD) adenocarcinomas were determined and compared between 35 laboratories by univariable and multivaria... περισσότερα »
Immunostains Used to Subtype Hepatic Adenomas Do Not Distinguish Hepatic Adenomas From Hepatocellular Carcinomas
[image: image]Immunostains are used to subtype hepatic adenomas to stratify for the risk of malignant transformation. The most common panel of immunostains used for this purpose includes liver fatty acid–binding protein (LFABP), serum amyloid A (SAA) protein, C-reactive protein (CRP), and glutamine synthetase (GS). Importantly, some pathologists use these stains in an attempt to distinguish hepatocellular carcinomas (HCC) from hepatic adenomas. However, there are limited data on the performance of these stains in HCCs. To investigate the staining characteristics of HCCs, we studied ... περισσότερα »
Design of TRUST, a non-interventional, multicenter, 3-year prospective study investigating an integrated patient management approach in patients with relapsing-remitting multiple sclerosis treated with natalizumab
Natalizumab provides rapid and high-efficacy control of multiple sclerosis disease activity with long-term stabilization. However, the benefits of the drug are countered by a risk of developing progressive mul... from Neurology via xlomafota13 on Inoreader http://ift.tt/2a8tdUk via IFTTT
Case control study: magnetic resonance spectroscopy of brain in HIV infected patients
In vivo proton magnetic resonance spectroscopy (1H-MRS) studies on brain in HIV infected patients have shown significant alteration in neuro-biochemicals. from Neurology via xlomafota13 on Inoreader http://ift.tt/29DKCFE via IFTTT
Chiral supramolecular polymerization leading to eye differentiable circular polarization in luminescence
[image: GA?id=C6CC05022K] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC05022K, Communication Jatish Kumar, Betsy Marydasan, Takuya Nakashima, Tsuyoshi Kawai, Junpei Yuasa A simple methodology to tune the chiroptical properties of a europium(III) complex in helical supramolecular polymerization is demonstrated wherein aggregation leads to enhanced luminescence dissymmetry. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreade... περισσότερα »
Radical Prostatectomy Findings in White Hispanic/Latino Men With NCCN Very Low-risk Prostate Cancer Detected by Template Biopsy
Radical prostatectomy (RP) outcomes have been studied in White and Black non-Hispanic men qualifying for Epstein active surveillance criteria (EASC). Herein, we first analyzed such outcomes in White Hispanic men. We studied 70 men with nonpalpable Gleason score 3+3=6 (Grade Group [GG] 1) prostate cancer (PCa) with ≤2 positive cores on biopsy who underwent RP.… Continue reading Radical Prostatectomy Findings in White Hispanic/Latino Men With NCCN Very Low-risk Prostate Cancer Detected by Template Biopsy
Cutaneous head and neck melanoma in OPTiM, a randomized phase 3 trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor for the treatment of unresected stage IIIB/IIIC/IV melanoma
Abstract Background Cutaneous head and neck melanoma has poor outcomes and limited treatment options. In OPTiM, a phase 3 study in patients with unresectable stage IIIB/IIIC/IV melanoma, intralesional administration of the oncolytic virus talimogene laherparepvec improved durable response rate (DRR; continuous response ≥6 months) compared with subcutaneous granulocyte-macrophage colony-stimulating factor (GM-CSF). Methods Retrospective review of… Continue reading Cutaneous head and neck melanoma in OPTiM, a randomized phase 3 trial of talimogene laherparepvec versus granulocyte-macr... περισσότερα »
Electronic data collection in epidemiological research
Objectives: This paper describes the use of Research Electronic Data Capture (REDCap) to conduct one of the follow-up waves of the 2004 Pelotas birth cohort. The aim is to point out the advantages and limitations of using this electronic data capture environment to collect data and control every step of a longitudinal epidemiological research, specially… Continue reading Electronic data collection in epidemiological research
Cutaneous head and neck melanoma in OPTiM, a randomized phase 3 trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor for the treatment of unresected stage IIIB/IIIC/IV melanoma
Cutaneous head and neck melanoma in OPTiM, a randomized phase 3 trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor for the treatment of unresected stage IIIB/IIIC/IV melanoma: Abstract Background Cutaneous head and neck melanoma has poor outcomes and limited treatment options. In OPTiM, a phase 3 study in patients with unresectable stage IIIB/IIIC/IV melanoma, intralesional… Continue reading Cutaneous head and neck melanoma in OPTiM, a randomized phase 3 trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor fo... περισσότερα »
Use of Text Searching for Trigger Words in Medical Records to Identify Adverse Drug Reactions within…
Purpose: To evaluate the performance of using trigger words (e.g. clues to an adverse drug reaction) in unstructured, narrative text to detect adverse drug reactions (ADRs) and compare the use of these trigger words to a targeted chart review for ADR detection within the intensive care unit (ICU) discharge summary note. Materials: A retrospective medical… Continue reading Use of Text Searching for Trigger Words in Medical Records to Identify Adverse Drug Reactions within…
Radical Prostatectomy Findings in White Hispanic/Latino Men With NCCN Very Low-risk Prostate Cancer Detected by Template Biopsy
[image: image]Radical prostatectomy (RP) outcomes have been studied in White and Black non-Hispanic men qualifying for Epstein active surveillance criteria (EASC). Herein, we first analyzed such outcomes in White Hispanic men. We studied 70 men with nonpalpable Gleason score 3+3=6 (Grade Group [GG] 1) prostate cancer (PCa) with ≤2 positive cores on biopsy who underwent RP. In 18 men, prostate-specific antigen (PSA) density (PSAD) was & gt;0.15 ng/mL/g. Three of these had insignificant and 15 had significant PCa. The remaining 52 men qualified for EASC. One patient had no PCa identified ... περισσότερα »
Reflex Estrogen Receptor (ER) and Progesterone Receptor (PR) Analysis of Ductal Carcinoma In Situ (DCIS) in Breast Needle Core Biopsy Specimens: An Unnecessary Exercise That Costs the United States $35 Million/y
[image: image]Most institutions reflexively test all breast core needle biopsy specimens showing ductal carcinoma in situ (DCIS) for estrogen receptor (ER) and progesterone receptor (PR). However, 5 factors suggest that this reflex testing unnecessarily increases costs. First, ER/PR results do not currently impact the next step in standard therapy; namely, surgical excision. Second, a subset of surgical excisions performed for DCIS diagnosed on core needle biopsy will harbor infiltrating mammary carcinoma, which will then need to be retested for ER/PR. Third, because ER and PR label... περισσότερα »
Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney
[image: image]Soft tissue undifferentiated round cell sarcoma (URCS) occurring in infants is a heterogenous group of tumors, often lacking known genetic abnormalities. On the basis of a t(10;17;14) karyotype in a pelvic URCS of a 4-month-old boy showing similar breakpoints with clear cell sarcoma of kidney (CCSK), we have investigated the possibility of shared genetic abnormalities in CCSK and soft tissue URCS. Most CCSKs are characterized by BCOR exon 16 internal tandem duplications (ITDs), whereas a smaller subset shows YWHAE-NUTM2B/E fusions. Because of overlapping clinicopatholo... περισσότερα »
Do Ancillary Studies Aid Detection and Classification of Barrett Esophagus?
[image: image]Barrett esophagus is a preneoplastic condition defined by the presence of intestinal metaplasia (ie, goblet cells) in an endoscopically apparent columnar-lined esophagus. Dysplasia is the most important risk factor for cancer development among patients with Barrett esophagus; approximately 6% of patients with high-grade dysplasia progress to adenocarcinoma within 1 year. Surgical pathologists are generally expected to address 2 clinical concerns when evaluating mucosal biopsy samples from patients with suspected Barrett esophagus; they should note the presence, or abse... περισσότερα »
Distinct Clinicopathologic and Genetic Features of 2 Histologic Subtypes of Intrahepatic Cholangiocarcinoma
[image: image]Previous studies have identified 2 clinically significant morphologic subtypes of intrahepatic cholangiocarcinoma (ICC) on the basis of anatomic location and/or histologic appearances. Recognizing that these classification schemes are not always applicable practically, this study aimed to establish a novel classification system based on mucin productivity and immunophenotype and to determine the rationale of this classification by examining the clinicopathologic and genetic characteristics of the 2 subtypes defined by this method. We retrospectively investigated 102 co... περισσότερα »
Pure Apocrine Carcinomas Represent a Clinicopathologically Distinct Androgen Receptor–Positive Subset of Triple-Negative Breast Cancers
[image: image]Apocrine carcinomas comprise ∼1% of all breast cancers and are characterized by large cells bearing abundant eosinophilic granular cytoplasm, round nuclei, and prominent nucleoli. They are typically estrogen receptor/progesterone receptor/HER2 negative, making them unresponsive to typical hormonal or HER2-based chemotherapy. However, this subtype of triple-negative breast cancers expresses androgen receptor (AR), a feature not shared by most nonapocrine triple-negative cancers (NA-TNCs). AR therefore represents a potential diagnostic tool and therapeutic target for apo... περισσότερα »
Cutaneous head and neck melanoma in OPTiM, a randomized phase 3 trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor for the treatment of unresected stage IIIB/IIIC/IV melanoma
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
[image: cover.gif?v=1&s=bc422faf3e5e5686ac05f12f] Abstract Background Cutaneous head and neck melanoma has poor outcomes and limited treatment options. In OPTiM, a phase 3 study in patients with unresectable stage IIIB/IIIC/IV melanoma, intralesional administration of the oncolytic virus talimogene laherparepvec improved durable response rate (DRR; continuous response ≥6 months) compared with subcutaneous granulocyte-macrophage colony-stimulating factor (GM-CSF). Methods Retrospective review of OPTiM identified patients with cutaneous head and neck melanoma given talimogene laher... περισσότερα »
Efficacy, outcomes, and complication rates of different surgical and nonsurgical treatment modalities for recurrent/residual oropharyngeal carcinoma: A systematic review and meta-analysis
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
[image: cover.gif?v=1&s=bc422faf3e5e5686ac05f12f] Abstract Background Treatment of recurrent oropharyngeal cancer is widely thought to have poor outcomes. Justification for treatment, especially in advanced cases, can be difficult. Methods A systematic search of MEDLINE, Embase, and Cochrane databases was conducted. Included studies reported specific recurrent oropharyngeal cancer survival data. Results Twenty-two retrospective studies were included. Pooled 3-year overall survival (OS) was 26% (95% confidence interval [CI] = 22% to 29%; I squared = 40.7%; *p* = .057). Pooled 5-y... περισσότερα »
Cutaneous head and neck melanoma in OPTiM, a randomized phase 3 trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor for the treatment of unresected stage IIIB/IIIC/IV melanoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Background Cutaneous head and neck melanoma has poor outcomes and limited treatment options. In OPTiM, a phase 3 study in patients with unresectable stage IIIB/IIIC/IV melanoma, intralesional administration of the oncolytic virus talimogene laherparepvec improved durable response rate (DRR; continuous response ≥6 months) compared with subcutaneous granulocyte-macrophage colony-stimulating factor (GM-CSF). Methods Retrospective review of […]
HIV/STIs risks between migrant MSM and local MSM: a cross-sectional comparison study in China
[image: fig-1-1x.jpg] Background. Internal migration plays a significant role in China's HIV epidemic. However, few studies have directly compared migrant men who have sex with men (MSM) with local MSM with regard to HIV/sexually transmitted infections (STIs) risks. Methods. We conducted a study in Guangzhou, China, with the aim of understanding the differences in HIV/STIs risks between migrant MSM and local MSM. A cross-sectional study was conducted among 273 migrant MSM and 249 local MSM in Guangzhou, China. Their behavioral and serologic data on HIV/syphilis were collected and c... περισσότερα »
Characterizing abnormal behavior in a large population of zoo-housed chimpanzees: prevalence and potential influencing factors
[image: fig-1-1x.jpg] Abnormal behaviors in captive animals are generally defined as behaviors that are atypical for the species and are often considered to be indicators of poor welfare. Although some abnormal behaviors have been empirically linked to conditions related to elevated stress and compromised welfare in primates, others have little or no evidence on which to base such a relationship. The objective of this study was to investigate a recent claim that abnormal behavior is endemic in the captive population by surveying a broad sample of chimpanzees (Pan troglodytes), whil... περισσότερα »
Dominant forest tree species are potentially vulnerable to climate change over large portions of their range even at high latitudes
[image: fig-1-1x.jpg] Projecting suitable conditions for a species as a function of future climate provides a reasonable, although admittedly imperfect, spatially explicit estimate of species vulnerability associated with climate change. Projections emphasizing range shifts at continental scale, however, can mask contrasting patterns at local or regional scale where management and policy decisions are made. Moreover, models usually show potential for areas to become climatically unsuitable, remain suitable, or become suitable for a particular species with climate change, but each o... περισσότερα »
New insight into the role of MMP14 in metabolic balance
[image: fig-1-1x.jpg] Membrane-anchored matrix metalloproteinase 14 (MMP14) is involved broadly in organ development through both its proteolytic and signal-transducing functions. Knockout of Mmp14(KO) in mice results in a dramatic reduction of body size and wasting followed by premature death, the mechanism of which is poorly understood. Since the mammary gland develops after birth and is thus dependent for its functional progression on systemic and local cues, we chose it as an organ model for understanding why KO mice fail to thrive. A global analysis of the mammary glands' prot... περισσότερα »
Cutaneous head and neck melanoma in OPTiM, a randomized phase 3 trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor for the treatment of unresected stage IIIB/IIIC/IV melanoma
[image: cover.gif?v=1&s=bc422faf3e5e5686ac05f12f] Abstract Background Cutaneous head and neck melanoma has poor outcomes and limited treatment options. In OPTiM, a phase 3 study in patients with unresectable stage IIIB/IIIC/IV melanoma, intralesional administration of the oncolytic virus talimogene laherparepvec improved durable response rate (DRR; continuous response ≥6 months) compared with subcutaneous granulocyte-macrophage colony-stimulating factor (GM-CSF). Methods Retrospective review of OPTiM identified patients with cutaneous head and neck melanoma given talimogene laherp... περισσότερα »
Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition In Vitro
Endocrinology, Early Release. from Endocrinology via ola Kala on Inoreader http://ift.tt/29DGKEo via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29CWSUg via IFTTT
Reflex Estrogen Receptor (ER) and Progesterone Receptor (PR) Analysis of Ductal Carcinoma In Situ (DCIS) in Breast Needle Core Biopsy Specimens: An Unnecessary Exercise That Costs the United States $35 Million/y
Most institutions reflexively test all breast core needle biopsy specimens showing ductal carcinoma in situ (DCIS) for estrogen receptor (ER) and progesterone receptor (PR). However, 5 factors suggest that this reflex testing unnecessarily increases costs. First, ER/PR results do not currently impact the next step in standard therapy; namely, surgical excision. Second, a subset of… Continue reading Reflex Estrogen Receptor (ER) and Progesterone Receptor (PR) Analysis of Ductal Carcinoma In Situ (DCIS) in Breast Needle Core Biopsy Specimens: An Unnecessary Exercise That Costs the Uni... περισσότερα »
Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney
Soft tissue undifferentiated round cell sarcoma (URCS) occurring in infants is a heterogenous group of tumors, often lacking known genetic abnormalities. On the basis of a t(10;17;14) karyotype in a pelvic URCS of a 4-month-old boy showing similar breakpoints with clear cell sarcoma of kidney (CCSK), we have investigated the possibility of shared genetic abnormalities… Continue reading Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney
Do Ancillary Studies Aid Detection and Classification of Barrett Esophagus?
Barrett esophagus is a preneoplastic condition defined by the presence of intestinal metaplasia (ie, goblet cells) in an endoscopically apparent columnar-lined esophagus. Dysplasia is the most important risk factor for cancer development among patients with Barrett esophagus; approximately 6% of patients with high-grade dysplasia progress to adenocarcinoma within 1 year. Surgical pathologists are generally expected… Continue reading Do Ancillary Studies Aid Detection and Classification of Barrett Esophagus?
Distinct Clinicopathologic and Genetic Features of 2 Histologic Subtypes of Intrahepatic Cholangiocarcinoma
Previous studies have identified 2 clinically significant morphologic subtypes of intrahepatic cholangiocarcinoma (ICC) on the basis of anatomic location and/or histologic appearances. Recognizing that these classification schemes are not always applicable practically, this study aimed to establish a novel classification system based on mucin productivity and immunophenotype and to determine the rationale of this classification… Continue reading Distinct Clinicopathologic and Genetic Features of 2 Histologic Subtypes of Intrahepatic Cholangiocarcinoma
Pure Apocrine Carcinomas Represent a Clinicopathologically Distinct Androgen Receptor–Positive Subset of Triple-Negative Breast Cancers
Apocrine carcinomas comprise ∼1% of all breast cancers and are characterized by large cells bearing abundant eosinophilic granular cytoplasm, round nuclei, and prominent nucleoli. They are typically estrogen receptor/progesterone receptor/HER2 negative, making them unresponsive to typical hormonal or HER2-based chemotherapy. However, this subtype of triple-negative breast cancers expresses androgen receptor (AR), a feature not shared… Continue reading Pure Apocrine Carcinomas Represent a Clinicopathologically Distinct Androgen Receptor–Positive Subset of Triple-Negative Breast Cancers
Analysis of NAB2-STAT6 Gene Fusion in 17 Cases of Meningeal Solitary Fibrous Tumor/Hemangiopericytoma: Review of the Literature
Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a mesenchymal tumor that can affect virtually any region of the body. SFT/HPC of the thoracic cavity and soft tissue has been histologically considered a single biological entity termed SFT; in fact, NAB2-STAT6 gene fusion was recently identified in both diseases. In contrast, meningeal SFT and HPC still need to… Continue reading Analysis of NAB2-STAT6 Gene Fusion in 17 Cases of Meningeal Solitary Fibrous Tumor/Hemangiopericytoma: Review of the Literature
Distinctive Patterns of CTNNB1 (β-Catenin) Alterations in Salivary Gland Basal Cell Adenoma and Basal Cell Adenocarcinoma
Salivary gland basaloid neoplasms are diagnostically challenging. Limited publications report that some basal cell adenomas harbor CTNNB1 mutations, and nuclear β-catenin expression is prevalent. We evaluated β-catenin expression in basal cell adenomas and adenocarcinomas in comparison with salivary tumors in the differential diagnosis and performed targeted genetic analysis on a subset of cases. β-catenin immunohistochemistry… Continue reading Distinctive Patterns of CTNNB1 (β-Catenin) Alterations in Salivary Gland Basal Cell Adenoma and Basal Cell Adenocarcinoma
Clinicopathologic Analysis of Angioimmunoblastic T-cell Lymphoma With or Without RHOA G17V Mutation Using Formalin-fixed Paraffin-embedded Sections
Angioimmunoblastic T-cell lymphoma (AITL) is an infrequent subtype of peripheral T-cell lymphoma derived from follicular helper T cells. Recently, a somatic G17V RHOA gene mutation has been reported. In this article, we examined the RHOA G17V mutation in 18 cases of AITL by 3 different techniques of Sanger sequencing, fully automated SNP genotyping, and deep… Continue reading Clinicopathologic Analysis of Angioimmunoblastic T-cell Lymphoma With or Without RHOA G17V Mutation Using Formalin-fixed Paraffin-embedded Sections
Anastomosing Hemangiomas Arising in Unusual Locations: A Clinicopathologic Study of 17 Soft Tissue Cases Showing a Predilection for the Paraspinal Region
Anastomosing hemangioma, a recently recognized benign vascular neoplasm originally described in the kidney, may be confused with well-differentiated angiosarcoma. Rare cases of anastomosing hemangiomas have been described in the liver and in nonrenal genitourinary sites. We report a series of 17 anastomosing hemangiomas occurring in unusual locations, in particular in the paravertebral soft tissues. The… Continue reading Anastomosing Hemangiomas Arising in Unusual Locations: A Clinicopathologic Study of 17 Soft Tissue Cases Showing a Predilection for the Paraspinal Region
Efficacy, outcomes, and complication rates of different surgical and nonsurgical treatment modalities for recurrent/residual oropharyngeal carcinoma: A systematic review and meta-analysis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Background Treatment of recurrent oropharyngeal cancer is widely thought to have poor outcomes. Justification for treatment, especially in advanced cases, can be difficult. Methods A systematic search of MEDLINE, Embase, and Cochrane databases was conducted. Included studies reported specific recurrent oropharyngeal cancer survival data. Results Twenty-two retrospective studies were included. Pooled 3-year overall survival […]
Cutaneous head and neck melanoma in OPTiM, a randomized phase 3 trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor for the treatment of unresected stage IIIB/IIIC/IV melanoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Background Cutaneous head and neck melanoma has poor outcomes and limited treatment options. In OPTiM, a phase 3 study in patients with unresectable stage IIIB/IIIC/IV melanoma, intralesional administration of the oncolytic virus talimogene laherparepvec improved durable response rate (DRR; continuous response ≥6 months) compared with subcutaneous granulocyte-macrophage colony-stimulating factor (GM-CSF). Methods Retrospective review of […]
Efficacy, outcomes, and complication rates of different surgical and nonsurgical treatment modalities for recurrent/residual oropharyngeal carcinoma: A systematic review and meta-analysis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Background Treatment of recurrent oropharyngeal cancer is widely thought to have poor outcomes. Justification for treatment, especially in advanced cases, can be difficult. Methods A systematic search of MEDLINE, Embase, and Cochrane databases was conducted. Included studies reported specific recurrent oropharyngeal cancer survival data. Results Twenty-two retrospective studies were included. Pooled 3-year overall survival […]
Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition In Vitro
Endocrinology, Early Release. from Endocrinology via ola Kala on Inoreader http://ift.tt/29DGKEo via IFTTT
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