Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Πέμπτη 24 Ιανουαρίου 2019

Prurigo successfully treated with duloxetine hydrochloride

Abstract

Prurigo is a common skin disease characterised by erythematous macules and papules/nodules with severe pruritus. We report here two cases with treatment‐resistant prurigo that were successfully treated with duloxetine hydrochloride, a serotonin–norepinephrine reuptake inhibitor. In vivo experiments with a mouse model of prurigo‐like inflammation showed that duloxetine hydrochloride ameliorated not only scratching behaviours, but also skin inflammation. Duloxetine hydrochloride appears to be useful for treating prurigo via modulating itch signals and immune responses.



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