Should the norepinephrine maximal dosage rate be greatly increased in late shock?
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
Should the norepinephrine maximal dosage rate be greatly increased in late shock?: Any advanced shock eventually degenerates into vasoplegia, which responds weakly to vasopressors. The highest reported norepinephrine flow rate is 3 μg/kg/min. We present the case of a young explosion victim, who was transferred in late haemorrhagic shock. Apart from usual treatment (hydration, mass transfusion protocol), single-agent norepinephrine was used to maintain a mean arterial pressure (MAP) of >60–65 mm Hg. For several hours, norepinephrine flow was 7–10 times the aforementioned (highest r... περισσότερα »
In-vivo confocal microscopy efficacy assessment of daylight photo dynamic therapy in actinic keratosis patients
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
In-vivo confocal microscopy efficacy assessment of daylight photo dynamic therapy in actinic keratosis patients: Abstract Background Reflectance confocal microscopy (RCM) is a non-invasive diagnostic technique with an acceptable sensitivity and specificity for actinic keratosis (AK). Objectives We evaluated efficacy of the DL-PDT in AK patients using a new RCM atypia scoring system. Methods All patients with AK lesions (Grade I- II) were included in our study (2012-2015). Baseline clinical, dermoscopy and RCM evaluation were followed by DL-PDT. In the first follow up, clinical exami... περισσότερα »
Swamp Cancer: Necrotizing hemorrhagic plaques
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Swamp Cancer: A Case of Human Pythiosis and Review of the Literature: Abstract Pythiosis is an infection caused by the aquatic oomycete, Pythium insidiosum. Commonly known as “swamp cancer” in veterinary pathology, pythiosis is now considered an emerging human disease associated with significant morbidity and mortality. However, many healthcare providers, including dermatologists, are unfamiliar with this diagnosis because clinical information is limited. A case of cutaneous pythiosis is presented to increase awareness of this life-threatening infection. We describe a middle-aged ma...περισσότερα »
Staphylococcus aureus and chronic folliculocentric pustuloses of the scalp – cause or association?
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Staphylococcus aureus and chronic folliculocentric pustuloses of the scalp – cause or association?: Abstract The aetiology of chronic scalp folliculitis (SF), folliculitis decalvans (FD), tufted folliculitis (TF), acne nuchae keloidalis (ANK), dissecting cellulitis (DCS) and other similar entities is not well established but these conditions share similar features including chronic scarring folliculocentric pustules localised to the scalp, response to antibiotic therapy and many show the presence of *Staphylococcus aureus* (SA). We have collectively termed these conditions chronic ... περισσότερα »
N-acyl ethanolamide and eicosanoid involvement in irritant dermatitis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
N-acyl ethanolamide and eicosanoid involvement in irritant dermatitis: Summary Background Sodium lauryl sulfate (SLS) and ultraviolet radiation (UVR) represent two commonly-encountered cutaneous inflammatory stimuli. Differing histopathological and clinical features implicate involvement of alternative inflammatory pathways; bioactive lipid mediators, including eicosanoids, endocannabinoids and sphingolipids, are likely candidates for regulation of the divergent inflammatory responses. Objectives Perform a comprehensive assessment of bioactive lipid involvement in SLS- and UVR-induc...περισσότερα »
Facial swelling: an atypical presentation of cutaneous lymphoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Facial swelling: an atypical presentation of cutaneous lymphoma: Abstract Background Cutaneous lymphomas (primary and secondary lymphomas involving the skin) are a heterogeneous group with various clinical manifestations, histological features, and prognoses. Methods We describe eight cases of cutaneous lymphoma presenting with facial swelling. Results Our case series included three cases of primary cutaneous extranodal natural killer/T-cell lymphoma, one case of secondary cutaneous extranodal natural killer/T-cell lymphoma, one case of subcutaneous panniculitis-like T-cell lymphoma... περισσότερα »
Disseminated anetoderma in a patient with nodal Epstein–Barr virus-associated classical Hodgkin lymphoma: Anetodermic form of a concurrent discordant cutaneous marginal zone lymphoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Disseminated anetoderma in a patient with nodal Epstein–Barr virus-associated classical Hodgkin lymphoma: Anetodermic form of a concurrent discordant cutaneous marginal zone lymphoma: Abstract Patients with a lymphoma have an increased risk of developing a second lymphoproliferative disorder. The association of nodal Hodgkin lymphoma and primary cutaneous marginal zone lymphoma (MALT type) is exceptional, and only very few cases have been documented. Anetoderma represents a circumscribed loss or rarefication of elastic fibers. Different underlying processes may result in anetoderma...περισσότερα »
Fixed hyperkeratotic plaques and transient erythematous patches : Erythrokeratodermia variabilis et progressiva
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Erythrokeratodermia variabilis et progressiva: Abstract Erythrokeratodermia variabilis et progressiva (EKVP) is a rare inherited skin disease characterized by fixed hyperkeratotic plaques and transient erythematous patches. EKVP is most often transmitted in an autosomal dominant manner. Causal mutations were found in the *GJB3*,* GJB4* and *GJA1* genes encoding connexins 31, 30.3 and 43, respectively. Approximately 50% of affected individuals develop palmoplantar keratoderma. Connexins are components of gap junctions, which are intercellular channels that are found in almost all ti...περισσότερα »
Darier disease : Small papules predominantly in seborrheic areas such as the face, chest and back
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
Darier disease: Abstract Darier disease (DD) is a type of inherited keratinizing disorder that exhibits autosomal dominant inheritance. DD is caused by the mutations of *ATP2A2*, which encodes an endoplasmic reticulum calcium pump, sarco/endoplasmic reticulum ATPase type 2 (SERCA2). DD often develops in childhood, persists through adolescence, and causes small papules predominantly in seborrheic areas such as the face, chest and back. Further, scales and scabs may gradually develop. DD may be accompanied by non-dermal symptoms, including psychiatric symptoms. Histologically, DD is ... περισσότερα »
A crusty and scaly lesion of the nose
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Pemphigus with features of both vulgaris and foliaceus variants localized to the nose: Abstract We report the case of a 74-year-old man affected by an unusual variant of pemphigus. He presented with a crusty and scaly lesion of the nose. We performed reflectance confocal microscopy and optical coherence tomography on the lesion, which suggested an unexpected diagnosis of pemphigus. Therefore, to confirm our diagnostic suspicions, we executed indirect immunofluorescence and two biopsies, one for histopathological examination and one for direct immunofluorescence. Histopathological e... περισσότερα »
A painless, slow-growing, brown nodule : Superficial CD34-positive fibroblastic tumor
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Superficial CD34-positive fibroblastic tumor: A new case from Japan: Abstract A 48-year-old Japanese woman presented with a painless, slow-growing, brown nodule of 15 mm in diameter on the left thigh. She noticed the nodule a few years before the first presentation to our hospital. She underwent total resection of the nodule. On histopathological examination, a relatively well-defined tumor with infiltrative growth was located in the dermis and extended into the subcutis. The tumor was composed of spindle to polygonal cells with pleomorphic nuclei arranged in a sheet-like or fascicu... περισσότερα »
Free virtual fossils for everyone
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 10 δευτερόλεπτα
MorphoSource.org archives 3-D images of bones from over 200 genera of both living and extinct animals. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1ptTaEa via IFTTT
Can migraine aura be provoked experimentally? A systematic review of potential methods for the provocation of migraine aura
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Can migraine aura be provoked experimentally? A systematic review of potential methods for the provocation of migraine aura: Background The nature of the migraine aura and its role in migraine pathophysiology is incompletely understood. In particular, the mechanisms underlying aura initiation and the causal relation between aura and headache are unknown. The scientific investigation of aura in patients is only possible if aura can be triggered. This paper reviews potential methods for the experimental provocation of migraine aura. Methods We systematically searched *PubMed* for stu... περισσότερα »
Spinal meningeal melanocytomas
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Spinal meningeal melanocytomas: clinical manifestations, radiological and pathological characteristics, and surgical outcomes: AbstractMeningeal melanocytoma is a rare benign tumor, most frequently located in the posterior fossa and spinal canal. The aim of this study was to investigate the clinical manifestations, radiological features, management, and follow-up data of spinal meningeal melanocytomas. We present the clinical data and long-term outcomes from a consecutive surgical series of 16 patients with pathologically diagnosed spinal meningeal melanocytomas. All of the patient...περισσότερα »
Erratum to: Guidance for the treatment of deep vein thrombosis and pulmonary embolism
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
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Special Issue in Honour of Philip M Beart
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
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Cellular Prion Protein Promotes Neuronal Differentiation of Adipose-Derived Stem Cells by Upregulating miRNA-124
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Abstract The cellular prion protein (PrPC) is a highly conserved glycoprotein anchored by glycosylphosphatidylinositol (GPI) to the cell surface and is also the source of pathogenic agent of scrapie prion protein (PrPSc). Numerous researches have suggested putative physiological roles for PrPC, including protection from ischemic and excitotoxic lesions, and participation in cell signaling and differentiation. […]
Model-based reconstruction for real-time phase-contrast flow MRI: Improved spatiotemporal accuracy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Purpose To develop a model-based reconstruction technique for real-time phase-contrast flow MRI with improved spatiotemporal accuracy in comparison to methods using phase differences of two separately reconstructed images with differential flow encodings. Methods The proposed method jointly computes a common image, a phase-contrast map, and a set of coil sensitivities from every pair of flow-compensated […]
An improved anatomical MRI technique with suppression of fixative fluid artifacts for the investigation of human postmortem brain phantoms
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Purpose Phantoms are often used to assess MR system stability in multicenter studies. Postmortem brain phantoms best replicate human brain anatomy, allowing for a combined assessment of the MR system and software chain for data analysis. However, a wash-out of fixative fluid affecting T1 values and thus T1-weighted sequences such as magnetization-prepared 180 degrees radiofrequency […]
Electrical conductivity and permittivity maps of brain tissues derived from water content based on T1-weighted acquisition
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Purpose To develop an electrical properties tomography (EPT) technique that can provide in vivo electrical conductivity and permittivity images of biological tissue without performing complex-valued radiofrequency field measurements. Theory and Methods Electrical conductivity and permittivity images are modeled as a monotonic function of tissues’ water content (W) under the principle of Maxwell’s mixture theory. Water […]
Simultaneous multislice imaging in dynamic cardiac MRI at 7T using parallel transmission
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Purpose Cardiac MRI at 7T suffers from contrast heterogeneity that can be mitigated with parallel transmission (pTX) and, when performed during breath-hold, from a limited number of slices that can be multiplied with multiband (MB) radiofrequency pulses by simultaneous excitation of multiple slices (SMS). The goal of this study was to apply both approaches simultaneously. […]
Cardiovascular autonomic control in paraplegic and quadriplegic
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Abstract Introduction Spinal cord injury (SCI) is commonly associated with devastating paralysis. This condition also results in cardiovascular autonomic dysfunction associated with increased mortality from cardiovascular disease. The purpose of this study was to explore the differences in cardiovascular autonomic modulation in individuals with and without SCI. Methods The study included 60 individuals: 30 individuals […]
Takotsubo cardiomyopathy in the setting of acute hydrocephalus secondary to neurocysticercosis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Abstract We report the case of a 45-year-old male who presented with transient neurogenic stunned myocardium, or takotsubo cardiomyopathy, secondary to acute hydrocephalus caused by obstruction of the third ventricle by neurocysticercosis. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1W2KOh6 via IFTTT
Meta-analysis of the safety and efficacy of droxidopa for neurogenic orthostatic hypotension
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Abstract Purpose Droxidopa has been approved for the treatment of neurogenic orthostatic hypotension (NOH) under the US Food and Drug Administration accelerated approval program, which warrants confirmatory evidence on long-term efficacy of droxidopa. Hereby, we synthesize evidence from published randomized controlled trials (RCTs) about the safety and efficacy of droxidopa for patients with neurogenic orthostatic […]
Relationships between p53 mutation, HPV status and outcome in oropharyngeal squamous cell carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Relationships between p53 mutation, HPV status and outcome in oropharyngeal squamous cell carcinoma: [image: gr1.sml] This study aimed to examine the rate and type of p53 mutation in oropharyngeal cancer (OSCC). Relationships were sought between human papillomavirus (HPV) status and p53 mutation. The role of p53 mutation as a prognostic factor independent of HPV status and as a modifier of the effect of HPV on outcomes was also examined.
Zika Virus Infects Human Cortical Neural Progenitors
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
and Attenuates Their Growth via Cell Stem Cell *Source:*Cell Stem Cell Author(s): Hengli Tang, Christy Hammack, Sarah C. Ogden, Zhexing Wen, Xuyu Qian, Yujing Li, Bing Yao, Jaehoon Shin, Feiran Zhang, Emily M. Lee, Kimberly M. Christian, Ruth A. Didier, Peng Jin, Hongjun Song, Guo-li Ming The suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and microcephaly is an urgent global health concern. The direct target cells of ZIKV in the developing human fetus are not clear. Here we show that a strain of the ZIKV, MR766, serially passaged in monkey and mosqu... περισσότερα »
Anatomical basis of the coordination between smooth and striated urethral and anal sphincters: loops of regulation between inferior hypogastric plexus and pudendal nerve. Immuno-histological study with 3D reconstruction
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Abstract Purpose (1) Describe both nervous pathways to the sphincters, and highlight the anatomical support of their coordination. (2) Obtain a 3D representation of this complex innervation system. Methods A computer-assisted anatomical dissection technique was used. Serial histological sections were cut in the pelvis of four female human foetuses (aged 19–32 weeks of gestation). The sections were treated with conventional staining, and with seven different immunostainings. The sections were digitalized and, finally, a 3D representation was built from the corresponding images. Re... περισσότερα »
Impact of an ICU EEG monitoring pathway on timeliness of therapeutic intervention and electrographic seizure termination
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 18 δευτερόλεπτα
Summary Objectives We aimed to determine whether implementation of a structured multidisciplinary electroencephalography (EEG) monitoring pathway improved the timeliness of administration of antiseizure medication in response to electrographic seizures in encephalopathic critically ill children. Methods A multidisciplinary team developed a pathway to standardize EEG monitoring and seizure management in encephalopathic critically ill children, aiming to decrease the time from electrographic seizure onset to antiseizure medication administration. Data were collected to inform the t... περισσότερα »
Temporal structure of human magnetic evoked fields
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 18 δευτερόλεπτα
Abstract Nonlinear analysis of the multifocal cortical visual evoked potential has allowed the identification of neural generation of higher-order nonlinear components by magnocellular and parvocellular neural streams. However, the location of individual brain sources that make such contributions to these evoked responses has not been studied. Thus, an *m*-sequence pseudorandom stimulus system was developed for use in magnetoencephalographic (MEG) studies. Five normal young adults were recorded using an Elekta TRIUX MEG with 306 sensors. Visual stimuli comprised a nine-patch dartbo...περισσότερα »
Stent-assisted coiling of intracranial aneurysms located on small vessels: midterm results with the LVIS Junior stent in 40 patients with 43 aneurysms
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 18 δευτερόλεπτα
Abstract Introduction The Low-profile Visualized Intraluminal Support (LVIS) Junior stent is dedicated for endovascular treatment of wide-neck intracranial aneurysms located on small-diameter vessels (2–3.5 mm). This study reports midterm clinical and anatomical results of this device. Methods This study was approved by authors' ethical committees. A retrospective review of our prospectively maintained database identified all patients treated by this stent in three institutions. Technical issues and immediate and mid-term anatomical and clinical outcomes were evaluated. Results ... περισσότερα »
Nanoparticles: Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy (Adv. Mater. 10/2016)
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 23 δευτερόλεπτα
[image: Thumbnail image of graphical abstract] Large-pore-sized hollow mesoporous organosilica nanoparticles (HMONs) are successfully synthesized by Y. Chen, Y. Li, J. Shi, and co-workers, as described on page 1963, using a stability-difference-based selective bond breakage (SD-SBB) strategy. Furthermore, surface-functionalized HMONs are constructed to concurrently deliver P-gp modulator siRNA and the anticancer drug DOX to reverse the multidrug resistance of cancer cells. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1UMDuaW via IFTTT
Contents: (Adv. Mater. 10/2016)
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 23 δευτερόλεπτα
from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1X6vrnQ via IFTTT
Nanocrystals: Pressure-Tuned Structure and Property of Optically Active Nanocrystals (Adv. Mater. 10/2016)
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 23 δευτερόλεπτα
[image: Thumbnail image of graphical abstract] Reversible tuning of the structure and optical properties of molecular nanocrystals is demonstrated by F. Bai, H. Fan, and co-workers on page 1989, through systematically applied pressure. Compression under high pressure can systematically tune the optical properties and mechanical stability of the molecular nanocrystals, providing new insights into molecular interactions. Exerting pressure-dependent control over atomic bonds and bond angles provides new opportunities for investigation of molecular coupling and energy-related applicati... περισσότερα »
3D Printing: Controlling Material Reactivity Using Architecture (Adv. Mater. 10/2016)
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 23 δευτερόλεπτα
[image: Thumbnail image of graphical abstract] Additive manufacturing, or 3D printing, has demonstrated great promise as a means for tailoring material behavior. To date, most studies have focused on improving the mechanical properties, and testing is often performed quasi-statically. On page 1934, K. T. Sullivan and co-workers demonstrate that 3D printing can be used to tailor the dynamic behavior of materials, so long as the feature sizes are made commensurate with the length scale of the governing phenomena. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.t... περισσότερα »
Electrocatalysts: Guided Evolution of Bulk Metallic Glass Nanostructures: A Platform for Designing 3D Electrocatalytic Surfaces (Adv. Mater. 10/2016)
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 23 δευτερόλεπτα
[image: Thumbnail image of graphical abstract] On page 1940, A. D. Taylor and co-workers demonstrate nanoporous bicontinuous structures using controlled structural evolution of metallic glass. By using techniques such as dealloying, galvanic replacement, and under-potential deposition, bulk-metallic-glass alloys can be pushed beyond their compositional limitations and tuned for a wide variety of interfacial and electrochemical reactions. Examples are illustrated for hydrogen and methanol oxidation, as well as oxygen reduction reactions. from Biomedical Engineering via xlomafota13 ...περισσότερα »
Masthead: (Adv. Mater. 10/2016)
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 23 δευτερόλεπτα
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Microfluidics: HYbriD Resonant Acoustics (HYDRA) (Adv. Mater. 10/2016)
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 23 δευτερόλεπτα
[image: Thumbnail image of graphical abstract] On page 1970, L. Y. Yeo and co-workers unravel and elucidate the existence of what they term a surface reflected bulk wave (SRBW), and show, quite counterintuitively, that it is possible to obtain an order-of-magnitude improvement in microfluidic manipulation efficiency, and, in particular, nebulization, through a unique combination of surface and bulk waves without increasing the complexity or cost. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1UMDqYz via IFTTT
An acido- and photochromic molecular device that mimics triode action
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 25 δευτερόλεπτα
[image: GA?id=C6CC00840B] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC00840B, Communication P. Remon, S. M. Li, M. Grotli, U. Pischel, J. Andreasson A molecular triode that is operated by pH and light can be implemented with spiropyrans. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1UMDtnd via IFTTT
Diagnosis and Management of Rhinosinusitis: Highlights from the 2015 Practice Parameter
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 29 δευτερόλεπτα
Abstract Rhinosinusitis is a commonly diagnosed disease in the USA. Rhinosinusitis is classified as acute, recurrent, or chronic (with or without nasal polyps). While acute rhinosinusitis is diagnosed by history and physical examination, chronic rhinosinusitis and recurrent acute rhinosinusitis are diagnosed based on symptoms and the presence of disease on either a sinus CT scan and/or endoscopy. Management of uncomplicated acute rhinosinusitis includes analgesics, saline irrigation, and/or intranasal steroids. Antibiotics and intranasal steroids are recommended for acute bacterial... περισσότερα »
Diagnosis and Management of Rhinosinusitis: Highlights from the 2015 Practice Parameter
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
Abstract Rhinosinusitis is a commonly diagnosed disease in the USA. Rhinosinusitis is classified as acute, recurrent, or chronic (with or without nasal polyps). While acute rhinosinusitis is diagnosed by history and physical examination, chronic rhinosinusitis and recurrent acute rhinosinusitis are diagnosed based on symptoms and the presence of disease on either a sinus CT scan […]
Superselective intraarterial cerebral infusion of cetuximab
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα
Superselective intraarterial cerebral infusion of cetuximab after osmotic blood/brain barrier disruption for recurrent malignant glioma: phase I study: Abstract*Objective* To establish a maximum tolerated dose of superselective intraarterial cerebral infusion (SIACI) of Cetuximab after osmotic disruption of the blood–brain barrier (BBB) with mannitol, and examine safety of the procedure in patients with recurrent malignant glioma. *Methods* A total of 15 patients with recurrent malignant glioma were included in the current study. The starting dose of Cetuximab was 100 mg/m2 and do... περισσότερα »
Pencil beam scanning proton therapy for pediatric intracranial ependymoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Pencil beam scanning proton therapy for pediatric intracranial ependymoma: AbstractTo assess the clinical outcome and late side effect profile of pencil beam scanning proton therapy (PT) delivered to children with intracranial ependymoma. Between July-2004 and March-2013, 50 patients with intracranial ependymoma (n = 46, grade 3) received involved-field PT at Paul Scherrer Institute (PSI). Median age at time of PT was 2.6 years (range 1.1–15.2). Thirty-six patients had infratentorial and 14 supratentorial ependymomas. Seventeen patients presented with macroscopic residual disease a... περισσότερα »
Primary diffuse leptomeningeal gliomatosis as a rare cause of pain in cervical spine
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Primary diffuse leptomeningeal gliomatosis as a rare cause of pain in cervical spine: Abstract BackgroundPrimary diffuse leptomeningeal gliomatosis (PDLG) is a very rare neuro-oncological disease, with only 90 cases of PDLG described in medical literature so far. Case presentationWe present a case report of a 56-years-old female patient, who was originally hospitalized due to cervical spine pain lasting several months. Despite complex diagnostics and treatment, the neurological state of the patient progressively deteriorated. Patient died 10 months after the first reported sym... περισσότερα »
ICU prognostic factors in critically ill patients with advanced solid tumors
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Intensive care unit prognostic factors in critically ill patients with advanced solid tumors: a 3-year retrospective study: Abstract BackgroundThe objective of this study was to identify risk factors predicting prognosis of critically ill medical patients with advanced solid tumors in the intensive care unit (ICU). MethodsWe retrospectively analyzed all ICU unplanned medical admissions to the ICU of patients with advanced solid cancer in Tianjin Medical University Cancer Institute and Hospital between October 1, 2012 and March 1, 2015. Approval was obtained from the Ethical Com... περισσότερα »
Low-Grade Dysplasia in Barrett’s Esophagus
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Healthcare Cost of Over-Diagnosis of Low-Grade Dysplasia in Barrett’s Esophagus: Abstract IntroductionPublished reports have demonstrated that many Barrett’s esophagus patients are over-diagnosed as low-grade dysplasia (BE-LGD). We performed an analysis of the surveillance and treatment costs associated with the over-diagnosis of BE-LGD. MethodsAs the principal cost variables, we used endoscopic and histologic procedures performed during the recommended surveillance intervals for patients with BE-LGD, the national average Medicare reimbursement for the Current Procedural Termi...περισσότερα »
Inadequate iodine nutrition of pregnant women in an area of iodine sufficiency
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Abstract Purpose I. R. Iran has been considered iodine replete since 2000, but iodine nutrition of vulnerable subjects is not clear. The main goal of this study was assessment of iodine nutrition and thyroid function in pregnant Iranian women. Methods A total of 1072 pregnant women from ten provinces in the different parts of the country were recruited from November to March 2014. Median urinary iodine concentration (UIC) as the measure of iodine status and serum free T4 (FT4), thyrotropin (TSH), thyroglobulin (Tg), anti-thyroglobulin and anti-thyroid peroxidase antibodies (TgAb ... περισσότερα »
Endocrine dysfunction in hereditary hemochromatosis
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Abstract Hereditary hemochromatosis (HH) is a genetic disorder of iron overload and subsequent organ damage. Five types of HH are known, classified by age of onset, genetic cause, clinical manifestations and mode of inheritance. Except for the rare form of juvenile haemochromatosis, symptoms do not usually appear until after decades of progressive iron loading and may be triggered by environmental and lifestyle factors. Despite the last decades discovery of genetic and phenotype diversity of HH, early studies showed a frequent involvement of the endocrine glands where diabetes and ... περισσότερα »
Anatomical basis of the coordination between smooth and striated urethral and anal sphincters: loops of regulation between inferior hypogastric plexus and pudendal nerve. Immuno-histological study with 3D reconstruction
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Abstract Purpose (1) Describe both nervous pathways to the sphincters, and highlight the anatomical support of their coordination. (2) Obtain a 3D representation of this complex innervation system. Methods A computer-assisted anatomical dissection technique was used. Serial histological sections were cut in the pelvis of four female human foetuses (aged 19–32 weeks of gestation). The sections were treated with conventional staining, and with seven different immunostainings. The sections were digitalized and, finally, a 3D representation was built from the corresponding images. Re... περισσότερα »
Women aged 45 years or younger : Body mass index and treatment outcomes following neoadjuvant therapy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Body mass index and treatment outcomes following neoadjuvant therapy in women aged 45 years or younger: evidence from a historic cohort.: Cancer Biol Ther. 2016 Mar 2;:0 Authors: D'Aiuto M, Chirico A, De Riggi MA, Frasci G, De Laurentiis M, Di Bonito M, Vici P, Pizzuti L, Sergi D, Marcello MS, Barba M, Giordano A Abstract PURPOSE: Large and consistent evidence supports the role of body mass index (BMI) as a prognostic and predictive indicator in breast cancer. However, there is paucity of data specifically referred to women diagnosed at a young age across the different disease sett...περισσότερα »
KLF4 is downregulated but not mutated during human esophageal squamous cell carcinogenesis and has tumor stage-specific functions.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
KLF4 is downregulated but not mutated during human esophageal squamous cell carcinogenesis and has tumor stage-specific functions.: Cancer Biol Ther. 2016 Mar 2;:0 Authors: Yang Y, Katz JP Abstract The transcriptional regulator Krüppel-like factor 4 (KLF4) is decreased in human esophageal squamous cell cancer (ESCC), and Klf4 deletion in mice produces squamous cell dysplasia. Nonetheless the mechanisms of KLF4 downregulation in ESCC and the functions of KLF4 during ESCC development and progression are not well understood. Here, we sought to define the regulation of KLF4 and deline... περισσότερα »
Radiotherapy for Graves’ disease
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
. The possible role of low-dose radiotherapy via Reports of Practical Oncology & Radiotherapy Publication date: May–June 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 3 Author(s): Meritxell Arenas, Sebastià Sabater, Pedro Lara Jiménez, Àngels Rovirosa, Albert Biete, Victoria Linares, Montse Belles, Julià Panés Immunomodulatory effects of low-dose radiotherapy (LD-RT) have been used for the treatment of several benign diseases, including arthrodegenerative and inflammatory pathologies. Graves’ disease is an autoimmune disease and radiotherapy (RT) is a ther... περισσότερα »
DPPIV/CD26: a tumor suppressor or a marker of malignancy?
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
DPPIV/CD26: a tumor suppressor or a marker of malignancy?: AbstractDipeptidyl peptidase IV (DPPIV/CD26) is a multifunctional protein with intrinsic peptidase activity that inactivates or degrades some bioactive peptides. It is the main cellular binding protein for ecto-adenosine deaminase and interacts with extracellular matrix proteins, besides participating in different signaling pathways. Due to these multiple functions, DPPIV/CD26 has been shown to be closely related to the tumor process. It has been reported that the progression of certain types of cancer is accompanied by a d... περισσότερα »
Long-term aspirin use linked to lower risk for tract cancers
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
Long-term aspirin use linked to lower risk for gastrointestinal tract cancers: Regular low doses of aspirin for at least six years was associated with a modestly reduced overall risk for cancer, primarily due to a lower risk for gastrointestinal tract cancer, especially colorectal cancers, according to an article. Regular low doses of aspirin for at least six years was associated with a modestly reduced overall risk for cancer, primarily due to a lower risk for gastrointestinal tract cancer, especially colorectal cancers, according to an article published online by JAMA Oncology.... περισσότερα »
Broccoli may offer protection against cancer
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
Broccoli may offer protection against liver cancer, study shows: Eating broccoli three to five times per week can lower the risk of many types of cancers, research has indicated. Consuming a high-fat, high-sugar diet and having excess body fat is linked with the development of nonalcoholic fatty liver disease (NAFLD), which can lead to diseases such as cirrhosis and liver cancer. A new study shows that including broccoli in the diet may protect against liver cancer, as well as aid in countering the development of NAFLD.
Brain metastases : Characterization of passive permeability at the blood–tumor barrier
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Characterization of passive permeability at the blood–tumor barrier in five preclinical models of brain metastases of breast cancer: AbstractThe blood–brain barrier (BBB) is compromised in brain metastases, allowing for enhanced drug permeation into brain. The extent and heterogeneity of BBB permeability in metastatic lesions is important when considering the administration of chemotherapeutics. Since permeability characteristics have been described in limited experimental models of brain metastases, we sought to define these changes in five brain-tropic breast cancer cell lines: M... περισσότερα »
Circulating tumor microemboli detected in metastatic melanoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
High expression of TRF2, SOX10, and CD10 in circulating tumor microemboli detected in metastatic melanoma patients. A potential impact for the assessment of disease aggressiveness: Abstract Circulating tumors cells (CTCs) can be detected in the blood of metastatic melanoma patients (MMPs) both as isolated circulating tumor cells (iCTCs) and circulating tumor microemboli (CTMs), but their clinical significance remains unknown. The aim of this work was to evaluate the prognostic impact in metastatic cutaneous melanoma of CTMs and iCTCs identified by a cytomorphological approach using... περισσότερα »
Paravertebral giant ganglioneuroma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Thoracolumbar paravertebral giant ganglioneuroma and scoliosis: a case report and literature review: AbstractParavertebral ganglioneuroma and scoliosis is a rare clinical benign disease. The case we reported is about a 12-year-old girl who was hospitalized due to neoplasm with spinal deformity in the right abdomen for 1 month. Based on a careful preoperative evaluation and found no obvious surgery contraindications, the patient was treated with surgical resection of the tumor and correction of the deformity by surgery. Postoperative pathologic examination confirmed it was a ganglio... περισσότερα »
Picornavirus Promotes Tumor Regression
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
A Tumor-Selective Picornavirus Promotes Tumor Regression: Picornaviruses have emerged as promising cancer therapies due to their ability to drive cytotoxic cellular immune responses and for promoting oncolysis. These properties include preferential replication in tumor cells, the induction of strong innate and adaptive immune responses, and the ease with which their genomes can be manipulated. We have developed Theiler's murine encephalomyelitis virus (TMEV) as an immunotherapy vector that promotes strong adaptive immune responses to tumor antigens embedded within its genome. To fu... περισσότερα »
Human Papillomavirus (HPV) Vaccination
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Human Papillomavirus (HPV) Vaccination Motivators, Barriers, and Brochure Preferences Among Parents in Multicultural Hawai‘i: a Qualitative Study: AbstractThe human papillomavirus (HPV) vaccine can prevent cervical and other cancers. Unfortunately, according to the National Immunization Survey—Teen 2014 data, completion of the HPV vaccine was only 38 % for 13- to 17-year-old girls and 31 % for 13- to17-year-old boys in the USA, and prevalence was similar in Hawai‘i. Parents’ acceptability of the HPV vaccine is critical for the vaccine uptake, and this can be increased by educationa...περισσότερα »
Tigecycline Inhibits Glioma Growth
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Tigecycline Inhibits Glioma Growth: Tigecycline is a broad-spectrum, first-in-class glycylcycline antibiotic currently used to treat complicated skin infections and community-acquired pneumonia. However, there is accumulating evidence showing that tigecycline has anticancer properties. In this study, we found tigecycline could inhibit cell proliferation by inducing cell-cycle arrest, but not apoptosis in glioma. To find the underlying mechanism of how tigecycline inhibits cell proliferation, the expression of miRNAs, which were related to regulating cell-cycle progression, was dete... περισσότερα »
Stent-assisted coiling of intracranial aneurysms located on small vessels: midterm results with the LVIS Junior stent in 40 patients with 43 aneurysms
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract Introduction The Low-profile Visualized Intraluminal Support (LVIS) Junior stent is dedicated for endovascular treatment of wide-neck intracranial aneurysms located on small-diameter vessels (2–3.5 mm). This study reports midterm clinical and anatomical results of this device. Methods This study was approved by authors' ethical committees. A retrospective review of our prospectively maintained database identified all patients treated by this stent in three institutions. Technical issues and immediate and mid-term anatomical and clinical outcomes were evaluated. Results ... περισσότερα »
Anatomical basis of the coordination between smooth and striated urethral and anal sphincters: loops of regulation between inferior hypogastric plexus and pudendal nerve. Immuno-histological study with 3D reconstruction
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract Purpose (1) Describe both nervous pathways to the sphincters, and highlight the anatomical support of their coordination. (2) Obtain a 3D representation of this complex innervation system. Methods A computer-assisted anatomical dissection technique was used. Serial histological sections were cut in the pelvis of four female human foetuses (aged 19–32 weeks of gestation). The sections were treated with conventional staining, and with seven different immunostainings. The sections were digitalized and, finally, a 3D representation was built from the corresponding images. Re... περισσότερα »
Coping strategies predict post-traumatic stress in patients with head and neck cancer
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract Evidence suggests that patients with head and neck cancer (HNC) are susceptible to post-traumatic stress disorder (PTSD). However, research is yet to examine predictors of PTSD symptoms in this patient group. The objective of this study was to investigate whether coping strategies at HNC diagnosis were related to outcomes of post-traumatic stress and health-related quality of life (HRQL) 6 months later. Sixty-five patients with HNC completed an assessment of coping, distress, and health-related quality of life at diagnosis and again 6 months later, and an assessment of po... περισσότερα »
Reconstruction of the denuded nasoseptal flap donor site with a free fascia lata graft: technical note
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract The nasoseptal flap provides hearty vascularized tissue for the reconstruction of skull base defects subsequent to expanded endonasal approaches; however, it leads to exposure of the cartilage at the septal donor site producing crusting and discomfort while it remucosalizes. We report an alternative technique to reconstruct the denuded nasal septal donor site by means of a free fascia lata graft. Fascia lata grafting of the nasoseptal flap donor site showed evidence of revascularization 4 weeks after initial surgery. Re-epithelialization was complete 4–12 weeks postoperat... περισσότερα »
Laryngeal dysplasia: a prospective cohort study of 70 patients
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract Laryngeal dysplasia is a poorly understood pre-malignant condition that requires diligent surveillance, to ensure timely diagnosis and optimal management. A dedicated laryngeal dysplasia clinic provides a platform for regular surveillance of these patients and for prospective data analysis. Our follow-up strategy is different to the recommendations from the ENT-UK consensus document on laryngeal dysplasia but appears to be a reasonable approach. The clinical appearance of the laryngeal lesion, histological grade of dysplasia and continual exposure to risk factors are fac... περισσότερα »
A novel short anionic antibacterial peptide isolated from the skin of Xenopus laevis with broad antibacterial activity and inhibitory activity against breast cancer cell
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract A vastarray of bioactive peptides from amphibian skin secretions is attracting increasing attention due to the growing problem of bacteria resistant to conventional antibiotics. In this report, a small molecular antibacterial peptide, named *Xenopus laevis* antibacterial peptide-P1 (XLAsp-P1), was isolated from the skin of *Xenopus laevis* using reversed-phase high-performance liquid chromatography. The primary structure of XLAsp-P1, which has been proved to be a novel peptide by BLAST search in AMP database, was DEDDD with a molecular weight of 607.7 Da analysed by Edman...περισσότερα »
Diagnosis and Management of Rhinosinusitis: Highlights from the 2015 Practice Parameter
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract Rhinosinusitis is a commonly diagnosed disease in the USA. Rhinosinusitis is classified as acute, recurrent, or chronic (with or without nasal polyps). While acute rhinosinusitis is diagnosed by history and physical examination, chronic rhinosinusitis and recurrent acute rhinosinusitis are diagnosed based on symptoms and the presence of disease on either a sinus CT scan and/or endoscopy. Management of uncomplicated acute rhinosinusitis includes analgesics, saline irrigation, and/or intranasal steroids. Antibiotics and intranasal steroids are recommended for acute bacterial... περισσότερα »
Management patterns of patients with cerebral metastases who underwent multiple stereotactic radiosurgeries
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract With escalating focus on cost containment, there is increasing scrutiny on the practice of multiple stereotactic radiosurgeries (SRSs) for patients with cerebral metastases distant to the initial tumor site. Our goal was to determine the survival patterns of patients with cerebral metastasis who underwent multiple SRSs. We retrospectively analyzed survival outcomes of 801 patients with 3683 cerebral metastases from primary breast, colorectal, lung, melanoma and renal histologies consecutively treated at the University of California, San Diego/San Diego Gamma Knife Center ... περισσότερα »
Combined inhibition of vascular endothelial growth factor receptor signaling with temozolomide enhances cytotoxicity against human glioblastoma cells via downregulation of Neuropilin-1
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor with grave prognosis. Despite the growing understanding of the complex signaling networks responsible for the initiation and progression of GBM, many experimental therapies have fallen short of their treatment goals. In the present study, we investigated the novel molecular mechanisms responsible for synergistic action of temozolomide (TMZ) and anti-VEGF therapy in GBM cells. We tested the combined effects of TMZ and VEGF blockade in four human GBM cell lines: TMZ-sensitive U251-MG ... περισσότερα »
Association of a variable number tandem repeat in the NLRP3 gene in women with susceptibility to RVVC
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract Vaginal infections with *Candida* spp. frequently occur in women of childbearing age. A small proportion of these women experience recurrent vulvovaginal candidosis (RVVC), which is characterized by at least three episodes of infection in one year. In addition to known risk factors such as antibiotics, diabetes, or pregnancy, host genetic variation and inflammatory pathways such as the IL-1/Th17 axis have been reported to play a substantial role in the pathogenesis of RVVC. In this study, we assessed a variable number tandem repeat (VNTR) polymorphism in the *NLRP3* gene ...περισσότερα »
Relationship between pathogenic, clinical, and virulence factors of Staphylococcus aureus in infective endocarditis versus uncomplicated bacteremia: a case–control study
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract Pathogenic factors of *Staphylococcus aureus* (SA) in the development of infective endocarditis (IE) have not been sufficiently investigated. The purpose of this study was to analyze the pathogenesis and virulence factors of SA in patients with IE as compared to patients with uncomplicated bacteremia (un-BAC). This is a retrospective case–control study (2002–2014) performed at a tertiary hospital in Spain. Clinical and epidemiological factors were analyzed. We assessed the presence of toxin genes [toxic shock syndrome toxin 1 (*tst*-1) and enterotoxins A (*etA*), B (*etB*)... περισσότερα »
Human basophil chemotaxis and activation are regulated via the histamine H4 receptor
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
[image: cover.gif?v=1&s=ff195289b99d5ad4af62a487] Abstract Background IgE-mediated cross-linking of FcεRI results in the release of mediators stored in basophil granules, such as histamine and proteases, and in the *de novo* synthesis of sulfidoleukotrienes. Objective In this study we investigated the role of the histamine receptors, in particular that of the histamine H4 receptor (H4R), in modulating human basophil function. Methods The mRNA expression of the histamine receptors was measured by real-time PCR. Migration of basophils was assessed by using the modified Boyden c...περισσότερα »
TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract Langerhans cells (LC) represent a specialized subset of evolutionarily conserved dendritic cells (DC) that populate stratified epithelial tissues, which are essential for the induction of skin and mucosal immunity and tolerance, including allergy. TGF-β1 has been confirmed to be a predominant factor involved in LC development. Despite great advances in the understanding of LC ontogeny and diverse replenishment patterns, the underlying molecular mechanisms remain elusive. This review focuses on the recent discoveries in TGF-β1-mediated LC development and maintenance, with ... περισσότερα »
Identification and characterization of DC-SIGN-binding glycoproteins in allergenic foods
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract Background DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) is a C-type lectin receptor expressed on macrophages and dendritic cells. DC-SIGN has high affinity for fucosylated glycans in several plant glycoproteins and pathogens. DC-SIGN is thought to be crucial for development of allergic sensitization. However, the precise role of DC-SIGN in food allergy pathogenesis is not yet understood. Objective We sought to characterize DC-SIGN-binding glycoproteins in a panel of allergenic and non-allergenic foods. Methods Fluorescent-la... περισσότερα »
An increased prevalence of self-reported allergic rhinitis in major Chinese cities from 2005 to 2011
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract Background The prevalence of allergic rhinitis (AR) has increased worldwide in recent decades. The present study was conducted to investigate the prevalence of self-reported AR and profiles of AR-related comorbidities in the adult population of China over time. Methods This study surveyed residents of 18 major cities in mainland China. Telephone interviews were conducted with study participants after sampling target telephone numbers by random digital dialing. The questions asked during telephone interviews were based on those included in validated questionnaires, and f... περισσότερα »
Absence of UCHL 1 function leads to selective motor neuropathy
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract Objective The aim of this study was to investigate the role of ubiquitin C-terminal hydrolase-L1 (UCHL1) for motor neuron circuitry and especially in spinal motor neuron (SMN) health, function, and connectivity. Methods Since mutations in *UCHL1* gene leads to motor dysfunction in patients, we investigated the role of UCHL1 on SMN survival, axon health, and connectivity with the muscle, by employing molecular and cellular marker expression analysis and electrophysiological recordings, in healthy wild-type and *Uchl1**nm3419* (UCHL1−/−) mice, which lack all UCHL1 functio... περισσότερα »
Classic Architecture with Multicentricity and Local Recurrence, and Absence of TERT Promoter Mutations are Correlates of BRAF V600E Harboring Pediatric Papillary Thyroid Carcinomas
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Abstract This study is aimed to investigate the *BRAF* *V600E* and *TERT* promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6–18). No *TERT* promoter mutations were identified in this series. The *BRAF* *V600E* mutation was present in 15 (30 %) tumors. From genotype-histologic variant correlation perspective, 13 of 24 classic variant PTCs and 2 of 7 diffuse sclerosing variant PTCs were found to harbor *BRAF* *V600E* mutation. One cribriform-morular ... περισσότερα »
Oncogenic BRAF Deletions
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
Oncogenic BRAF Deletions Functioning as Homodimers [Research Articles]: We have identified previously undiscovered *BRAF* in-frame deletions near the αC-helix region of the kinase domain in pancreatic, lung, ovarian, and thyroid cancers. These deletions are mutually exclusive with *KRAS* mutations and occur in 4.21% of *KRAS* wild-type pancreatic cancer. siRNA knockdown in cells harboring *BRAF* deletions showed that the MAPK activity and cell growth are BRAF dependent. Structurally, the BRAF deletions are predicted to shorten the β3/αC-helix loop and hinder its flexibility by lock...περισσότερα »
Personalized Medicine in Melanoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
Personalized Medicine in Melanoma [Research Articles]: Targeted therapies and immunotherapies have transformed melanoma care, extending median survival from ~9 to over 25 months, but nevertheless most patients still die of their disease. The aim of precision medicine is to tailor care for individual patients and improve outcomes. To this end, we developed protocols to facilitate individualized treatment decisions for patients with advanced melanoma, analyzing 364 samples from 214 patients. Whole exome sequencing (WES) and targeted sequencing of circulating tumor DNA (ctDNA) allowed... περισσότερα »
Role of miRNAs in Tumor Progression
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
Role of miRNAs in Tumor Progression [Review]: miRNAs are a key component of the noncoding RNA family. The underlying mechanisms involved in the interplay between the tumor microenvironment and cancer cells involve highly dynamic factors such as hypoxia and cell types such as cancer-associated fibroblasts and macrophages. Although miRNA levels are known to be altered in cancer cells, recent evidence suggests a critical role for the tumor microenvironment in regulating miRNA biogenesis, methylation, and transcriptional changes. Here, we discuss the complex protumorigenic symbiotic ro...περισσότερα »
Management patterns of patients with cerebral metastases who underwent multiple stereotactic radiosurgeries
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Management patterns of patients with cerebral metastases who underwent multiple stereotactic radiosurgeries: AbstractWith escalating focus on cost containment, there is increasing scrutiny on the practice of multiple stereotactic radiosurgeries (SRSs) for patients with cerebral metastases distant to the initial tumor site. Our goal was to determine the survival patterns of patients with cerebral metastasis who underwent multiple SRSs. We retrospectively analyzed survival outcomes of 801 patients with 3683 cerebral metastases from primary breast, colorectal, lung, melanoma and renal...περισσότερα »
Mammary analogue secretory carcinoma of parotid
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Mammary analogue secretory carcinoma of parotid: Is preoperative cytological diagnosis possible?: Mammary analogue secretory carcinoma is a recently recognized tumor of salivary gland with characteristic t(12;15)(q13;q25) that results in ETV6-NTRK3 fusion product. Distinguishing mammary analogue secretory carcinoma from other salivary gland tumors is important. Present study highlights cytologic findings in three cases of mammary analogue secretory carcinoma of parotid which facilitate preoperative diagnosis with the aid of ancillary diagnostic techniques. Fine needle aspiration cy...περισσότερα »
EBV-associated gastric carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 47 δευτερόλεπτα
Expression and prognostic roles of PIK3CA, JAK2, PD-L1 and PD-L2 in EBV-associated gastric carcinoma: As a special subtype of gastric carcinoma, Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) has distinct clinicopathological features. The Cancer Genome Atlas (TCGA) Research Network revealed that EBVaGC also has distinct molecular features: PIK3CA mutations, DNA hypermethylation, and JAK2, PD-L1 and PD-L2 amplification. Here, we evaluated PIK3CA, JAK2, PD-L1 and PD-L2 expression in 59 EBVaGC and 796 EBV-negative gastric carcinoma (EBVnGC) cases using immunohistochemis... περισσότερα »
NRAS Protein in Follicular-patterned Thyroid Tumors
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 47 δευτερόλεπτα
Immunohistochemical Detection of NRAS Protein in Follicular-patterned Thyroid Tumors: The NRASA182G mutation, which results in the NRASQ61R protein, is a major driver mutation in follicular-patterned thyroid neoplasms. Although new immunohistochemistry (IHC) for NRASQ61R is now available, its sensitivity, specificity and diagnostic utility for thyroid tumors are not yet established. We performed IHC for NRASQ61R and direct sequencing for NRAS codon 61 in four thyroid cancer-derived cell lines and 98 follicular-patterned thyroid tumors that included 22 follicular thyroid adenomas (FT...περισσότερα »
Model-based reconstruction for real-time phase-contrast flow MRI: Improved spatiotemporal accuracy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Purpose To develop a model-based reconstruction technique for real-time phase-contrast flow MRI with improved spatiotemporal accuracy in comparison to methods using phase differences of two separately reconstructed images with differential flow encodings. Methods The proposed method jointly computes a common image, a phase-contrast map, and a set of coil sensitivities from every pair of flow-compensated […]
An improved anatomical MRI technique with suppression of fixative fluid artifacts for the investigation of human postmortem brain phantoms
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Purpose Phantoms are often used to assess MR system stability in multicenter studies. Postmortem brain phantoms best replicate human brain anatomy, allowing for a combined assessment of the MR system and software chain for data analysis. However, a wash-out of fixative fluid affecting T1 values and thus T1-weighted sequences such as magnetization-prepared 180 degrees radiofrequency […]
Electrical conductivity and permittivity maps of brain tissues derived from water content based on T1-weighted acquisition
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Purpose To develop an electrical properties tomography (EPT) technique that can provide in vivo electrical conductivity and permittivity images of biological tissue without performing complex-valued radiofrequency field measurements. Theory and Methods Electrical conductivity and permittivity images are modeled as a monotonic function of tissues’ water content (W) under the principle of Maxwell’s mixture theory. Water […]
Simultaneous multislice imaging in dynamic cardiac MRI at 7T using parallel transmission
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Purpose Cardiac MRI at 7T suffers from contrast heterogeneity that can be mitigated with parallel transmission (pTX) and, when performed during breath-hold, from a limited number of slices that can be multiplied with multiband (MB) radiofrequency pulses by simultaneous excitation of multiple slices (SMS). The goal of this study was to apply both approaches simultaneously. […]
Cardiovascular autonomic control in paraplegic and quadriplegic
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Abstract Introduction Spinal cord injury (SCI) is commonly associated with devastating paralysis. This condition also results in cardiovascular autonomic dysfunction associated with increased mortality from cardiovascular disease. The purpose of this study was to explore the differences in cardiovascular autonomic modulation in individuals with and without SCI. Methods The study included 60 individuals: 30 individuals […]
Takotsubo cardiomyopathy in the setting of acute hydrocephalus secondary to neurocysticercosis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Abstract We report the case of a 45-year-old male who presented with transient neurogenic stunned myocardium, or takotsubo cardiomyopathy, secondary to acute hydrocephalus caused by obstruction of the third ventricle by neurocysticercosis. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1W2KOh6 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Meta-analysis of the safety and efficacy of droxidopa for neurogenic orthostatic hypotension
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Abstract Purpose Droxidopa has been approved for the treatment of neurogenic orthostatic hypotension (NOH) under the US Food and Drug Administration accelerated approval program, which warrants confirmatory evidence on long-term efficacy of droxidopa. Hereby, we synthesize evidence from published randomized controlled trials (RCTs) about the safety and efficacy of droxidopa for patients with neurogenic orthostatic […]
The effect of prone positioning with surgical bolsters on liver blood flow in healthy volunteers
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Summary This study sought to identify changes in hepatic flood flow and cardiac output during prone positioning on surgical bolsters in awake volunteers, and was prompted by a local incident of significant hepatic dysfunction following surgery in the prone position. Cardiac output was determined using the non-invasive Peñáz technique, and plasma disappearance rate of indocyanine […]
Differential visceral blood flow in the hyperdynamic circulation of patients with liver cirrhosis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Summary Background With advancing liver disease and the development of portal hypertension, there are major alterations in somatic and visceral blood flow. Using phase-contrast magnetic resonance angiography, we characterised alterations in blood flow within the hepatic, splanchnic and extra-splanchnic circulations of patients with established liver cirrhosis. Aims To compare blood flow in splanchnic and extra-splanchnic […]
Stent-assisted coiling of intracranial aneurysms located on small vessels: midterm results with the LVIS Junior stent in 40 patients with 43 aneurysms
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Abstract Introduction The Low-profile Visualized Intraluminal Support (LVIS) Junior stent is dedicated for endovascular treatment of wide-neck intracranial aneurysms located on small-diameter vessels (2–3.5 mm). This study reports midterm clinical and anatomical results of this device. Methods This study was approved by authors’ ethical committees. A retrospective review of our prospectively maintained database identified all […]
Hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Immunohistochemistry for 2-Succinocysteine (2SC) and Fumarate Hydratase (FH) in Cutaneous Leiomyomas May Aid in Identification of Patients With HLRCC (Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome).: [image: wk-health-logo.gif] Hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC) is caused by germline mutations in the fumarate hydratase (FH) gene and predisposes to cutaneous and uterine leiomyomas and renal cell carcinoma (RCC). HLRCC-associated renal tumors are clinically aggressive, and patients would benefit from surveillance and early detection. Cut...περισσότερα »
Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney.: [image: wk-health-logo.gif] Soft tissue undifferentiated round cell sarcoma (URCS) occurring in infants is a heterogenous group of tumors, often lacking known genetic abnormalities. On the basis of a t(10;17;14) karyotype in a pelvic URCS of a 4-month-old boy showing similar breakpoints with clear cell sarcoma of kidney (CCSK), we have investigated the possibility of shared genetic abnorm... περισσότερα »
Incidental and Isolated Follicular Lymphoma In Situ and Mantle Cell Lymphoma In Situ Lack Clinical Significance.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Incidental and Isolated Follicular Lymphoma In Situ and Mantle Cell Lymphoma In Situ Lack Clinical Significance.: [image: wk-health-logo.gif] Follicular lymphoma in situ (FLIS) and mantle cell lymphoma in situ (MCLIS) are histopathologic findings of undetermined clinical significance. We studied a series of 341 consecutive lymph node resection specimens from patients diagnosed with colorectal (201 cases) and breast (140 cases) adenocarcinoma between 1998 and 2000. Incidental and isolated FLIS was identified in 11/341 patients (3.23%), whereas incidental and isolated MCLIS was foun... περισσότερα »
Sentinel lymph node biopsy for head and neck mucosal cancers
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Sentinel lymph node biopsy for head and neck mucosal cancers - an update on the current evidence: Abstract Regional metastases are a prominent feature of mucosal-associated head and neck squamous cell carcinomas and are an important prognostic factor. Sentinel lymph node biopsy (SLNB) is one modality that has potential to add to the accuracy of neck staging, though it is currently not used as widely in the head and neck as it is in other areas such as breast cancer. We review the efficacy of SLNB in head and neck mucosal squamous cell carcinomas and provide an overview of current p...περισσότερα »
Self-reported allergic rhinitis in major cities
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
An increased prevalence of self-reported allergic rhinitis in major Chinese cities from 2005 to 2011: Abstract Background The prevalence of allergic rhinitis (AR) has increased worldwide in recent decades. The present study was conducted to investigate the prevalence of self-reported AR and profiles of AR-related comorbidities in the adult population of China over time. Methods This study surveyed residents of 18 major cities in mainland China. Telephone interviews were conducted with study participants after sampling target telephone numbers by random digital dialing. The questions... περισσότερα »
Identification and characterization of DC-SIGN-binding glycoproteins in allergenic foods
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Identification and characterization of DC-SIGN-binding glycoproteins in allergenic foods: Abstract Background DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) is a C-type lectin receptor expressed on macrophages and dendritic cells. DC-SIGN has high affinity for fucosylated glycans in several plant glycoproteins and pathogens. DC-SIGN is thought to be crucial for development of allergic sensitization. However, the precise role of DC-SIGN in food allergy pathogenesis is not yet understood. Objective We sought to characterize DC-SIGN-binding gl... περισσότερα »
TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance: Abstract Langerhans cells (LC) represent a specialized subset of evolutionarily conserved dendritic cells (DC) that populate stratified epithelial tissues, which are essential for the induction of skin and mucosal immunity and tolerance, including allergy. TGF-β1 has been confirmed to be a predominant factor involved in LC development. Despite great advances in the understanding of LC ontogeny and diverse replenishment patterns, the underlying molecular mechanisms remain elusive. This revie...περισσότερα »
Human basophil chemotaxis and activation are regulated via the histamine H4 receptor
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Human basophil chemotaxis and activation are regulated via the histamine H4 receptor: [image: cover.gif?v=1&s=ff195289b99d5ad4af62a487] Abstract Background IgE-mediated cross-linking of FcεRI results in the release of mediators stored in basophil granules, such as histamine and proteases, and in the *de novo* synthesis of sulfidoleukotrienes. Objective In this study we investigated the role of the histamine receptors, in particular that of the histamine H4 receptor (H4R), in modulating human basophil function. Methods The mRNA expression of the histamine receptors was measured by... περισσότερα »
Diagnosis and Management of Rhinosinusitis: Highlights from the 2015 Practice Parameter
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Diagnosis and Management of Rhinosinusitis: Highlights from the 2015 Practice Parameter: AbstractRhinosinusitis is a commonly diagnosed disease in the USA. Rhinosinusitis is classified as acute, recurrent, or chronic (with or without nasal polyps). While acute rhinosinusitis is diagnosed by history and physical examination, chronic rhinosinusitis and recurrent acute rhinosinusitis are diagnosed based on symptoms and the presence of disease on either a sinus CT scan and/or endoscopy. Management of uncomplicated acute rhinosinusitis includes analgesics, saline irrigation, and/or int...περισσότερα »
Laryngeal dysplasia
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Laryngeal dysplasia: a prospective cohort study of 70 patients: Abstract Laryngeal dysplasia is a poorly understood pre-malignant condition that requires diligent surveillance, to ensure timely diagnosis and optimal management. A dedicated laryngeal dysplasia clinic provides a platform for regular surveillance of these patients and for prospective data analysis. Our follow-up strategy is different to the recommendations from the ENT-UK consensus document on laryngeal dysplasia but appears to be a reasonable approach. The clinical appearance of the laryngeal lesion, histological grade... περισσότερα »
Reconstruction of the denuded nasoseptal flap donor site with a free fascia lata graft: technical note
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Reconstruction of the denuded nasoseptal flap donor site with a free fascia lata graft: technical note: AbstractThe nasoseptal flap provides hearty vascularized tissue for the reconstruction of skull base defects subsequent to expanded endonasal approaches; however, it leads to exposure of the cartilage at the septal donor site producing crusting and discomfort while it remucosalizes. We report an alternative technique to reconstruct the denuded nasal septal donor site by means of a free fascia lata graft. Fascia lata grafting of the nasoseptal flap donor site showed evidence of re... περισσότερα »
HNC : Coping strategies predict post-traumatic stress
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Coping strategies predict post-traumatic stress in patients with head and neck cancer: AbstractEvidence suggests that patients with head and neck cancer (HNC) are susceptible to post-traumatic stress disorder (PTSD). However, research is yet to examine predictors of PTSD symptoms in this patient group. The objective of this study was to investigate whether coping strategies at HNC diagnosis were related to outcomes of post-traumatic stress and health-related quality of life (HRQL) 6 months later. Sixty-five patients with HNC completed an assessment of coping, distress, and health-r...περισσότερα »
Proteomic approach reveals that starch degradation contributes to anthocyanin accumulation in tuberous root of purple sweet potato
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 55 δευτερόλεπτα
Publication date: Available online 6 March 2016 *Source:*Journal of Proteomics Author(s): Shaoqing Wang, Dezhuo Pan, Xiaojie Lv, Xiaomin Song, Zhimin Qiu, Chunmei Huang, Ronghui Huang, Wei Chen A comparative proteomic approach was carried out to investigate anthocyanin biosynthesis in the tuberous roots of yellow sweet potato (YSP) and purple sweet potato (PSP) cultivars. More than 800 proteins were reproducibly detected through two-dimensional electrophoresis (2-DE), of which 50 proteins with 39 more and 11 less accumulated in PSP were identified through matrix-assisted laser desor...περισσότερα »
Electron trapping on Fe3+ sites in photodoped ZnO colloidal nanocrystals
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 55 δευτερόλεπτα
[image: GA?id=C6CC00514D] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC00514D, Communication Dongming Zhou, Kevin R. Kittilstved Experimental study of photodoped colloidal Fe-doped ZnO quantum dots suggest electrons trap on Fe3+ sites before accumulating in the ZnO conduction band. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1W2Loey via IFTTT
Copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes: an efficient approach to functionalized quinazolines
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 55 δευτερόλεπτα
[image: GA?id=C6CC00946H] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC00946H, Communication Liwen Fan, Tao Wang, Ying Tian, Fei Xiong, Simei Wu, Qingjin Liang, Junfeng Zhao The first copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes was described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/21RYJgT via IFTTT
Coping strategies predict post-traumatic stress in patients with head and neck cancer
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
Abstract Evidence suggests that patients with head and neck cancer (HNC) are susceptible to post-traumatic stress disorder (PTSD). However, research is yet to examine predictors of PTSD symptoms in this patient group. The objective of this study was to investigate whether coping strategies at HNC diagnosis were related to outcomes of post-traumatic stress and health-related quality of life (HRQL) 6 months later. Sixty-five patients with HNC completed an assessment of coping, distress, and health-related quality of life at diagnosis and again 6 months later, and an assessment of po... περισσότερα »
Reconstruction of the denuded nasoseptal flap donor site with a free fascia lata graft: technical note
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
Abstract The nasoseptal flap provides hearty vascularized tissue for the reconstruction of skull base defects subsequent to expanded endonasal approaches; however, it leads to exposure of the cartilage at the septal donor site producing crusting and discomfort while it remucosalizes. We report an alternative technique to reconstruct the denuded nasal septal donor site by means of a free fascia lata graft. Fascia lata grafting of the nasoseptal flap donor site showed evidence of revascularization 4 weeks after initial surgery. Re-epithelialization was complete 4–12 weeks postoperat... περισσότερα »
Laryngeal dysplasia: a prospective cohort study of 70 patients
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
Abstract Laryngeal dysplasia is a poorly understood pre-malignant condition that requires diligent surveillance, to ensure timely diagnosis and optimal management. A dedicated laryngeal dysplasia clinic provides a platform for regular surveillance of these patients and for prospective data analysis. Our follow-up strategy is different to the recommendations from the ENT-UK consensus document on laryngeal dysplasia but appears to be a reasonable approach. The clinical appearance of the laryngeal lesion, histological grade of dysplasia and continual exposure to risk factors are fac... περισσότερα »
Coping strategies predict post-traumatic stress in patients with head and neck cancer
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
Abstract Evidence suggests that patients with head and neck cancer (HNC) are susceptible to post-traumatic stress disorder (PTSD). However, research is yet to examine predictors of PTSD symptoms in this patient group. The objective of this study was to investigate whether coping strategies at HNC diagnosis were related to outcomes of post-traumatic stress and health-related quality of life (HRQL) 6 months later. Sixty-five patients with HNC completed an assessment of coping, distress, and health-related quality of life at diagnosis and again 6 months later, and an assessment of po... περισσότερα »
Reconstruction of the denuded nasoseptal flap donor site with a free fascia lata graft: technical note
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
Abstract The nasoseptal flap provides hearty vascularized tissue for the reconstruction of skull base defects subsequent to expanded endonasal approaches; however, it leads to exposure of the cartilage at the septal donor site producing crusting and discomfort while it remucosalizes. We report an alternative technique to reconstruct the denuded nasal septal donor site by means of a free fascia lata graft. Fascia lata grafting of the nasoseptal flap donor site showed evidence of revascularization 4 weeks after initial surgery. Re-epithelialization was complete 4–12 weeks postoperat... περισσότερα »
Laryngeal dysplasia: a prospective cohort study of 70 patients
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
Abstract Laryngeal dysplasia is a poorly understood pre-malignant condition that requires diligent surveillance, to ensure timely diagnosis and optimal management. A dedicated laryngeal dysplasia clinic provides a platform for regular surveillance of these patients and for prospective data analysis. Our follow-up strategy is different to the recommendations from the ENT-UK consensus document on laryngeal dysplasia but appears to be a reasonable approach. The clinical appearance of the laryngeal lesion, histological grade of dysplasia and continual exposure to risk factors are fac... περισσότερα »
Diagnosis and Management of Rhinosinusitis: Highlights from the 2015 Practice Parameter
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
Abstract Rhinosinusitis is a commonly diagnosed disease in the USA. Rhinosinusitis is classified as acute, recurrent, or chronic (with or without nasal polyps). While acute rhinosinusitis is diagnosed by history and physical examination, chronic rhinosinusitis and recurrent acute rhinosinusitis are diagnosed based on symptoms and the presence of disease on either a sinus CT scan and/or endoscopy. Management of uncomplicated acute rhinosinusitis includes analgesics, saline irrigation, and/or intranasal steroids. Antibiotics and intranasal steroids are recommended for acute bacterial... περισσότερα »
Human basophil chemotaxis and activation are regulated via the histamine H4 receptor
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
[image: cover.gif?v=1&s=ff195289b99d5ad4af62a487] Abstract Background IgE-mediated cross-linking of FcεRI results in the release of mediators stored in basophil granules, such as histamine and proteases, and in the *de novo* synthesis of sulfidoleukotrienes. Objective In this study we investigated the role of the histamine receptors, in particular that of the histamine H4 receptor (H4R), in modulating human basophil function. Methods The mRNA expression of the histamine receptors was measured by real-time PCR. Migration of basophils was assessed by using the modified Boyden c...περισσότερα »
TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
Abstract Langerhans cells (LC) represent a specialized subset of evolutionarily conserved dendritic cells (DC) that populate stratified epithelial tissues, which are essential for the induction of skin and mucosal immunity and tolerance, including allergy. TGF-β1 has been confirmed to be a predominant factor involved in LC development. Despite great advances in the understanding of LC ontogeny and diverse replenishment patterns, the underlying molecular mechanisms remain elusive. This review focuses on the recent discoveries in TGF-β1-mediated LC development and maintenance, with ... περισσότερα »
Coping strategies predict post-traumatic stress in patients with head and neck cancer
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Evidence suggests that patients with head and neck cancer (HNC) are susceptible to post-traumatic stress disorder (PTSD). However, research is yet to examine predictors of PTSD symptoms in this patient group. The objective of this study was to investigate whether coping strategies at HNC diagnosis were related to outcomes of post-traumatic stress and health-related quality of life (HRQL) 6 months later. Sixty-five patients with HNC completed an assessment of coping, distress, and health-related quality of life at diagnosis and again 6 months later, and an assessment of po... περισσότερα »
Reconstruction of the denuded nasoseptal flap donor site with a free fascia lata graft: technical note
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract The nasoseptal flap provides hearty vascularized tissue for the reconstruction of skull base defects subsequent to expanded endonasal approaches; however, it leads to exposure of the cartilage at the septal donor site producing crusting and discomfort while it remucosalizes. We report an alternative technique to reconstruct the denuded nasal septal donor site by means of a free fascia lata graft. Fascia lata grafting of the nasoseptal flap donor site showed evidence of revascularization 4 weeks after initial surgery. Re-epithelialization was complete 4–12 weeks postoperat... περισσότερα »
Laryngeal dysplasia: a prospective cohort study of 70 patients
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Laryngeal dysplasia is a poorly understood pre-malignant condition that requires diligent surveillance, to ensure timely diagnosis and optimal management. A dedicated laryngeal dysplasia clinic provides a platform for regular surveillance of these patients and for prospective data analysis. Our follow-up strategy is different to the recommendations from the ENT-UK consensus document on laryngeal dysplasia but appears to be a reasonable approach. The clinical appearance of the laryngeal lesion, histological grade of dysplasia and continual exposure to risk factors are fac... περισσότερα »
Econometrics, Vol. 4, Pages 11: Parallelization Experience with Four Canonical Econometric Models Using ParMitISEM
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
This paper presents the parallel computing implementation of the MitISEM algorithm, labeled Parallel MitISEM. The basic MitISEM algorithm provides an automatic and flexible method to approximate a non-elliptical target density using adaptive mixtures of Student-t densities, where only a kernel of the target density is required. The approximation can be used as a candidate density in Importance Sampling or Metropolis Hastings methods for Bayesian inference on model parameters and probabilities. We present and discuss four canonical econometric models using a Graphics Processing Unit... περισσότερα »
Drought Tolerance Is Correlated with the Activity of Antioxidant Enzymes in Cerasus humilis Seedlings
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Cerasus humilis, grown in the northern areas of China, may experience water deficit during their life cycle, which induces oxidative stress. Our present study was conducted to evaluate the role of oxidative stress management in the leaves of two C. humilis genotypes, HR (drought resistant) and ND4 (drought susceptible), when subjected to a long-term soil drought (WS). The HR plants maintained lower membrane injury due to low ROS and MDA accumulation compared to ND4 plants during a long-term WS. This is likely attributed to global increase in the activities of superoxide dismutase ... περισσότερα »
Analysis of Shear Bond Strength and Morphology of Er:YAG Laser-Recycled Ceramic Orthodontic Brackets
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Objective. The aim of this study was to compare the recycling of deboned ceramic brackets via an Er:YAG laser or via the traditional chairside processing methods of flaming and sandblasting; shear bond strength and morphological changes were evaluated in recycled brackets versus new brackets. Materials and Methods. 3M Clarity Self-Ligating Ceramic Brackets with a microcrystalline base were divided into groups subjected to flaming, sandblasting, or exposure to an Er:YAG laser. New ceramic brackets served as a control group. Shear bond strengths were determined with an Electroforce ... περισσότερα »
Plasma ionization under simulated ambient Mars conditions for quantification of methane by mass spectrometry
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
[image: GA?id=C5AN02305J] *Analyst*, 2016, Advance Article *DOI*: 10.1039/C5AN02305J, Paper Mazdak Taghioskoui, Mona Zaghloul A miniature plasma was formed under simulated ambient Mars conditions and used for mass spectrometric quantification of methane. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1TYXUxX via IFTTT
Luminescent ZnO quantum dots as efficient sensor for free chlorine detection in water
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C5AN02599K, Paper Kulvinder Singh, S.K. Mehta HHighly luminescent ZnO Quantum Dots (QDs) synthesized via a simple facile route is used for the preparation of optical sensor for the detection of free chlorine. The concentration of free... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1p1Ccw6 via IFTTT
Microporous silk carbon-ionic liquid composite for electrochemical sensor of dopamine
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C6AN00016A, Paper Min Wang, Lu Bai, Ling Ling Zhang, Guangping Sun, Xiaowei Zhang, Shaojun Dong Porous silk carbon (Silk C) was obtained through carbonization and KOH activation of the natural silk cocoon. The as-prepared Silk C presented good characteristics of large surface area (SBET: 2854.53... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1p1Caoc via IFTTT
Sustainability, Vol. 8, Pages 245: Sustainability and Competitiveness of Romanian Farms through Organic Agriculture
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Currently, the development of any sector involves respecting the principles of sustainability, which means economic, social and environmental development. Moreover, organic farming is a very important field for ensuring sustainable development. Romania has great potential for the development of organic agriculture, especially due to the large number of available farmland and reduced use of fertilizers and other chemicals. However, the development of organic farming in Romania is in an early stage, due to the numerous problems that Romanian agriculture is still facing. Concern for ... περισσότερα »
Management patterns of patients with cerebral metastases who underwent multiple stereotactic radiosurgeries
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Abstract With escalating focus on cost containment, there is increasing scrutiny on the practice of multiple stereotactic radiosurgeries (SRSs) for patients with cerebral metastases distant to the initial tumor site. Our goal was to determine the survival patterns of patients with cerebral metastasis who underwent multiple SRSs. We retrospectively analyzed survival outcomes of 801 patients with 3683 cerebral metastases from primary breast, colorectal, lung, melanoma and renal histologies consecutively treated at the University of California, San Diego/San Diego Gamma Knife Center ... περισσότερα »
Combined inhibition of vascular endothelial growth factor receptor signaling with temozolomide enhances cytotoxicity against human glioblastoma cells via downregulation of Neuropilin-1
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Abstract Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor with grave prognosis. Despite the growing understanding of the complex signaling networks responsible for the initiation and progression of GBM, many experimental therapies have fallen short of their treatment goals. In the present study, we investigated the novel molecular mechanisms responsible for synergistic action of temozolomide (TMZ) and anti-VEGF therapy in GBM cells. We tested the combined effects of TMZ and VEGF blockade in four human GBM cell lines: TMZ-sensitive U251-MG ... περισσότερα »
Anatomical basis of the coordination between smooth and striated urethral and anal sphincters: loops of regulation between inferior hypogastric plexus and pudendal nerve. Immuno-histological study with 3D reconstruction
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Purpose (1) Describe both nervous pathways to the sphincters, and highlight the anatomical support of their coordination. (2) Obtain a 3D representation of this complex innervation system. Methods A computer-assisted anatomical dissection technique was used. Serial histological sections were cut in the pelvis of four female human foetuses (aged 19–32 weeks of gestation). The sections were treated with conventional staining, and with seven different immunostainings. The sections were digitalized and, finally, a 3D representation was built from the corresponding images. Re... περισσότερα »
Identification and characterization of DC-SIGN-binding glycoproteins in allergenic foods
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Background DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) is a C-type lectin receptor expressed on macrophages and dendritic cells. DC-SIGN has high affinity for fucosylated glycans in several plant glycoproteins and pathogens. DC-SIGN is thought to be crucial for development of allergic sensitization. However, the precise role of DC-SIGN in food allergy pathogenesis is not yet understood. Objective We sought to characterize DC-SIGN-binding glycoproteins in a panel of allergenic and non-allergenic foods. Methods Fluorescent-la... περισσότερα »
An increased prevalence of self-reported allergic rhinitis in major Chinese cities from 2005 to 2011
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Background The prevalence of allergic rhinitis (AR) has increased worldwide in recent decades. The present study was conducted to investigate the prevalence of self-reported AR and profiles of AR-related comorbidities in the adult population of China over time. Methods This study surveyed residents of 18 major cities in mainland China. Telephone interviews were conducted with study participants after sampling target telephone numbers by random digital dialing. The questions asked during telephone interviews were based on those included in validated questionnaires, and f... περισσότερα »
Diagnosis and Management of Rhinosinusitis: Highlights from the 2015 Practice Parameter
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Rhinosinusitis is a commonly diagnosed disease in the USA. Rhinosinusitis is classified as acute, recurrent, or chronic (with or without nasal polyps). While acute rhinosinusitis is diagnosed by history and physical examination, chronic rhinosinusitis and recurrent acute rhinosinusitis are diagnosed based on symptoms and the presence of disease on either a sinus CT scan and/or endoscopy. Management of uncomplicated acute rhinosinusitis includes analgesics, saline irrigation, and/or intranasal steroids. Antibiotics and intranasal steroids are recommended for acute bacterial... περισσότερα »
Human basophil chemotaxis and activation are regulated via the histamine H4 receptor
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: cover.gif?v=1&s=ff195289b99d5ad4af62a487] Abstract Background IgE-mediated cross-linking of FcεRI results in the release of mediators stored in basophil granules, such as histamine and proteases, and in the *de novo* synthesis of sulfidoleukotrienes. Objective In this study we investigated the role of the histamine receptors, in particular that of the histamine H4 receptor (H4R), in modulating human basophil function. Methods The mRNA expression of the histamine receptors was measured by real-time PCR. Migration of basophils was assessed by using the modified Boyden c...περισσότερα »
Longitudinal Assessment of Effort–Reward Imbalance and Job Strain Across Pregnancy: A Preliminary Study
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Objectives To assess longitudinal changes in occupational effort–reward imbalance (ERI) and demand-control (DC) scores across pregnancy and examine associations with blood pressure (BP) during pregnancy. Methods A pilot repeated-measures survey was administered four times to a sample of working women across pregnancy using the ERI and DC instruments. Demographic data and blood pressure measurements… Continue reading Longitudinal Assessment of Effort–Reward Imbalance and Job Strain Across Pregnancy: A Preliminary Study
Diagnosis and Management of Rhinosinusitis: Highlights from the 2015 Practice Parameter
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Rhinosinusitis is a commonly diagnosed disease in the USA. Rhinosinusitis is classified as acute, recurrent, or chronic (with or without nasal polyps). While acute rhinosinusitis is diagnosed by history and physical examination, chronic rhinosinusitis and recurrent acute rhinosinusitis are diagnosed based on symptoms and the presence of disease on either a sinus CT scan… Continue reading Diagnosis and Management of Rhinosinusitis: Highlights from the 2015 Practice Parameter
AII amacrine cells: quantitative reconstruction and morphometric analysis of electrophysiologically identified cells in live rat retinal slices imaged with multi-photon excitation microscopy
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract AII amacrine cells have been found in all mammalian retinas examined and play an important role for visual processing under both scotopic and photopic conditions. Whereas ultrastructural investigations have provided a detailed understanding of synaptic connectivity, there is little information available with respect to quantitative properties and variation of cellular morphology. Here, we performed… Continue reading AII amacrine cells: quantitative reconstruction and morphometric analysis of electrophysiologically identified cells in live rat retinal slices imaged with mult... περισσότερα »
A role for the anteromedial thalamic nucleus in the acquisition of contextual fear memory to predatory threats
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Previous studies from our group have shown that cytotoxic lesions in the ventral portion of the anteromedial thalamic nucleus (AMv), one of the main targets of the hypothalamic predator-responsive circuit, strongly impairs contextual fear responses to an environment previously associated with a predator. The AMv is in a position to convey information to cortico-hippocampal-amygdalar… Continue reading A role for the anteromedial thalamic nucleus in the acquisition of contextual fear memory to predatory threats
Management patterns of patients with cerebral metastases who underwent multiple stereotactic radiosurgeries
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract With escalating focus on cost containment, there is increasing scrutiny on the practice of multiple stereotactic radiosurgeries (SRSs) for patients with cerebral metastases distant to the initial tumor site. Our goal was to determine the survival patterns of patients with cerebral metastasis who underwent multiple SRSs. We retrospectively analyzed survival outcomes of 801 patients… Continue reading Management patterns of patients with cerebral metastases who underwent multiple stereotactic radiosurgeries
Combined inhibition of vascular endothelial growth factor receptor signaling with temozolomide enhances cytotoxicity against human glioblastoma cells via downregulation of Neuropilin-1
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor with grave prognosis. Despite the growing understanding of the complex signaling networks responsible for the initiation and progression of GBM, many experimental therapies have fallen short of their treatment goals. In the present study, we investigated the novel molecular mechanisms… Continue reading Combined inhibition of vascular endothelial growth factor receptor signaling with temozolomide enhances cytotoxicity against human glioblastoma cells via downregulation of Neuropilin-1
Association of a variable number tandem repeat in the NLRP3 gene in women with susceptibility to RVVC
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Vaginal infections with Candida spp. frequently occur in women of childbearing age. A small proportion of these women experience recurrent vulvovaginal candidosis (RVVC), which is characterized by at least three episodes of infection in one year. In addition to known risk factors such as antibiotics, diabetes, or pregnancy, host genetic variation and inflammatory pathways… Continue reading Association of a variable number tandem repeat in the NLRP3 gene in women with susceptibility to RVVC
Relationship between pathogenic, clinical, and virulence factors of Staphylococcus aureus in infective endocarditis versus uncomplicated bacteremia: a case–control study
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Pathogenic factors of Staphylococcus aureus (SA) in the development of infective endocarditis (IE) have not been sufficiently investigated. The purpose of this study was to analyze the pathogenesis and virulence factors of SA in patients with IE as compared to patients with uncomplicated bacteremia (un-BAC). This is a retrospective case–control study (2002–2014) performed at… Continue reading Relationship between pathogenic, clinical, and virulence factors of Staphylococcus aureus in infective endocarditis versus uncomplicated bacteremia: a case–control study
Vestibular contribution to three-dimensional dynamic (allocentric) and two-dimensional static (egocentric) spatial memory
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UMwjQ2 via IFTTT
Association between i.v. thrombolysis volume and door-to-needle times in acute ischemic stroke
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Centralization of intravenous thrombolysis (IVT) for acute ischemic stroke in high-volume centers is believed to improve the door-to-needle times (DNT), but limited data support this assumption. We examined the association between DNT and IVT volume in a large Dutch province. We identified consecutive patients treated with IVT between January 2009 and 2013. Based on… Continue reading Association between i.v. thrombolysis volume and door-to-needle times in acute ischemic stroke
An Unusual Solitary Thyroid Nodule with Bloody Follicles: Metastatic Renal Cell Carcinoma Within an Infiltrative Follicular Variant Papillary Carcinoma
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 1 ώρα
from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Tltx4E via IFTTT
Food allergy is associated with Staphylococcus aureus colonization in children with atopic dermatitis
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 6 March 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Andrea L. Jones, Douglas Curran-Everett, Donald Y.M. Leung from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1YlQDHY via IFTTT
Temporal structure of human magnetic evoked fields
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Nonlinear analysis of the multifocal cortical visual evoked potential has allowed the identification of neural generation of higher-order nonlinear components by magnocellular and parvocellular neural streams. However, the location of individual brain sources that make such contributions to these evoked responses has not been studied. Thus, an *m*-sequence pseudorandom stimulus system was developed for use in magnetoencephalographic (MEG) studies. Five normal young adults were recorded using an Elekta TRIUX MEG with 306 sensors. Visual stimuli comprised a nine-patch dartbo...περισσότερα »
Inadequate iodine nutrition of pregnant women in an area of iodine sufficiency
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Purpose I. R. Iran has been considered iodine replete since 2000, but iodine nutrition of vulnerable subjects is not clear. The main goal of this study was assessment of iodine nutrition and thyroid function in pregnant Iranian women. Methods A total of 1072 pregnant women from ten provinces in the different parts of the country were recruited from November to March 2014. Median urinary iodine concentration (UIC) as the measure of iodine status and serum free T4 (FT4), thyrotropin (TSH), thyroglobulin (Tg), anti-thyroglobulin and anti-thyroid peroxidase antibodies (TgAb ... περισσότερα »
Recent emergence of photon upconversion based on triplet energy migration in molecular assemblies
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα
[image: GA?id=C6CC00089D] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC00089D, Feature Article Nobuhiro Yanai, Nobuo Kimizuka This Feature Article reviews an emerging field of triplet energy migration-based photon upconversion (TEM-UC) that allows highly efficient photon upconversion at low excitation power. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1U6Jmei via IFTTT
Longitudinal Assessment of Effort–Reward Imbalance and Job Strain Across Pregnancy: A Preliminary Study
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα
Abstract Objectives To assess longitudinal changes in occupational effort–reward imbalance (ERI) and demand-control (DC) scores across pregnancy and examine associations with blood pressure (BP) during pregnancy. Methods A pilot repeated-measures survey was administered four times to a sample of working women across pregnancy using the ERI and DC instruments. Demographic data and blood pressure measurements were collected at each interval. Growth mixture modeling was used to examine trajectories of change in occupational characteristics. Associations with BP were examined using r...περισσότερα »
Fabrication of Janus droplets by evaporation driven liquid-liquid phase separation
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC00249H, Communication Qingquan Zhang, Meng Xu, Xiaojun Liu, Wenfeng Zhao, Chenghua Zong, Yang Yu, Qi Wang, Hongwei Gai We present a universal and scalable method to fabricate Janus droplets based on evaporation driven liquid-liquid phase separation. In this work, the morphologies and chemical properties of separate parts of... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1nqXX7F via IFTTT
Sero-prevalence of vitamin D deficiency among pediatric subjects visiting central railway hospital, Byculla, Mumbai, India: a cross sectional study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
2016-03-07T03-00-57Z *Source:* International Journal of Contemporary Pediatrics Ajay B. Kale, Mohd Haseeb, Dipti Jain, Bharat Jain, Apurva Deshmukh. Background: Vitamin D deficiency leads to improper bone mineralization and causes rickets in children. Recently role of vitamin D has been found in a wide range of physiological functions, including cell differentiation, immune function and insulin production. Methods: This study was hospital-based cross-sectional study. Participants were recruited from population of young children aged 6 months to 15 years attending Dr. Babasaheb Ambed... περισσότερα »
Ophthalmoplegia heralding the onset of anti-amphiphysin related paraneoplastic stiff person syndrome
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QFnJx9 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Classic Architecture with Multicentricity and Local Recurrence, and Absence of TERT Promoter Mutations are Correlates of BRAF V600E Harboring Pediatric Papillary Thyroid Carcinomas
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract This study is aimed to investigate the BRAF V600E and TERT promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6–18). No TERT promoter mutations were identified in this series. The BRAF V600E mutation was present […]
An Unusual Solitary Thyroid Nodule with Bloody Follicles: Metastatic Renal Cell Carcinoma Within an Infiltrative Follicular Variant Papillary Carcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Tltx4E via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Food allergy is associated with Staphylococcus aureus colonization in children with atopic dermatitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 6 March 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Andrea L. Jones, Douglas Curran-Everett, Donald Y.M. Leung from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YlQDHY via IFTTT
Early radiation-induced liver toxicities are associated with poor survival in patients with advanced hepatocellular carcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Aim Little is known about the impact of radiotherapy associated early hepatic toxicities. This study is to investigate the risk factors and outcome of early radiation-induced liver disease (early-RILD) in patients with hepatocellular carcinoma. Methods One hundred patients with advanced hepatocellular carcinoma receiving hepatic radiotherapy were included in this retrospective analysis. All had no […]
Effect of statin and aspirin use on toxicity and pathological complete response rate of neo-adjuvant chemoradiation for rectal cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Aim To retrospectively evaluate the potential impact of statin and aspirin use on acute toxicity and pathological complete response (pCR) rate in rectal cancer patients receiving neo-adjuvant long-course radiation therapy (LCRT) with concurrent chemotherapy. Methods A retrospective review was performed of all patients undergoing neo-adjuvant LCRT for rectal adenocarcinoma at the Regional Cancer Treatment […]
Simultaneous optimization of limited sampling points for pharmacokinetic analysis of amrubicin and amrubicinol in cancer patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Aim Limited sampling points for both amrubicin (AMR) and its active metabolite amrubicinol (AMR-OH) were simultaneously optimized using Akaike’s information criterion (AIC) calculated by pharmacokinetic modeling. Methods In this pharmacokinetic study, 40 mg/m2 of AMR was administered as a 5-min infusion on three consecutive days to 21 Japanese lung cancer patients. Blood samples were […]
Prostate cancer – evidence of exercise and nutrition trial (PrEvENT): study protocol for a randomised controlled feasibility trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background A growing body of observational evidence suggests that nutritional and physical activity interventions are associated with beneficial outcomes for men with prostate cancer, including brisk walking, lycopene intake, increased fruit and vegetable intake and reduced dairy consumption. However, randomised controlled trial data are limited. The ‘Prostate Cancer: Evidence of Exercise and Nutrition Trial’ […]
Rectal indomethacin alone versus indomethacin and prophylactic pancreatic stent placement for preventing pancreatitis after ERCP: study protocol for a randomized controlled trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background The combination of prophylactic pancreatic stent placement (PSP) – a temporary plastic stent placed in the pancreatic duct – and rectal non-steroidal anti-inflammatory drugs (NSAIDs) is recommended for preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in high-risk cases. Preliminary data, however, suggest that PSP may be unnecessary if rectal NSAIDs are administered. Given […]
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medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
(Source: Journal of Pain and Symptom Management) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R2DqUJ via IFTTT
TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Langerhans cells (LC) represent a specialized subset of evolutionarily conserved dendritic cells (DC) that populate stratified epithelial tissues, which are essential for the induction of skin and mucosal immunity and tolerance, including allergy. TGF-β1 has been confirmed to be a predominant factor involved in LC development. Despite great advances in the understanding of LC ontogeny and diverse replenishment patterns, the underlying molecular mechanisms remain elusive. This review focuses on the recent discoveries in TGF-β1-mediated LC development and maintenance, with ... περισσότερα »
Identification and characterization of DC-SIGN-binding glycoproteins in allergenic foods
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Background DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) is a C-type lectin receptor expressed on macrophages and dendritic cells. DC-SIGN has high affinity for fucosylated glycans in several plant glycoproteins and pathogens. DC-SIGN is thought to be crucial for development of allergic sensitization. However, the precise role of DC-SIGN in food allergy pathogenesis is not yet understood. Objective We sought to characterize DC-SIGN-binding glycoproteins in a panel of allergenic and non-allergenic foods. Methods Fluorescent-la... περισσότερα »
An increased prevalence of self-reported allergic rhinitis in major Chinese cities from 2005 to 2011
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Background The prevalence of allergic rhinitis (AR) has increased worldwide in recent decades. The present study was conducted to investigate the prevalence of self-reported AR and profiles of AR-related comorbidities in the adult population of China over time. Methods This study surveyed residents of 18 major cities in mainland China. Telephone interviews were conducted with study participants after sampling target telephone numbers by random digital dialing. The questions asked during telephone interviews were based on those included in validated questionnaires, and f... περισσότερα »
Food allergy is associated with Staphylococcus aureus colonization in children with atopic dermatitis
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 6 March 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Andrea L. Jones, Douglas Curran-Everett, Donald Y.M. Leung from #ENT via xlomafota13 on Inoreader http://ift.tt/1YlQDHY via IFTTT
Food allergy is associated with Staphylococcus aureus colonization in children with atopic dermatitis
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 6 March 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Andrea L. Jones, Douglas Curran-Everett, Donald Y.M. Leung from #ENT via xlomafota13 on Inoreader http://ift.tt/1YlQDHY via IFTTT
Complementary clinical effects of red complex bacteria on generalized periodontitis in a caucasian population
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Objectives To relate five periodontopathogenic bacteria, including the red complex, to the severity, extent, and inflammation of the periodontal lesion in Caucasian patients with generalized aggressive and chronic periodontitis and to explore whether tobacco use is associated with a specific bacterial profile. Materials & Methods A cross-sectional and analytic study was conducted in patients with aggressive and chronic periodontitis. Data were gathered on socio-demographic and periodontal variables, and RT-PCR was used to determine subgingival bacterial profile. Linear ...περισσότερα »
Sentinel lymph node biopsy for head and neck mucosal cancers - an update on the current evidence
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Regional metastases are a prominent feature of mucosal-associated head and neck squamous cell carcinomas and are an important prognostic factor. Sentinel lymph node biopsy (SLNB) is one modality that has potential to add to the accuracy of neck staging, though it is currently not used as widely in the head and neck as it is in other areas such as breast cancer. We review the efficacy of SLNB in head and neck mucosal squamous cell carcinomas and provide an overview of current practice and include details of technical advances. This article is protected by copyright. All ri...περισσότερα »
Human basophil chemotaxis and activation are regulated via the histamine H4 receptor
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background IgE-mediated cross-linking of FcεRI results in the release of mediators stored in basophil granules, such as histamine and proteases, and in the de novo synthesis of sulfidoleukotrienes. Objective In this study we investigated the role of the histamine receptors, in particular that of the histamine H4 receptor (H4R), in modulating human basophil function. […]
TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Langerhans cells (LC) represent a specialized subset of evolutionarily conserved dendritic cells (DC) that populate stratified epithelial tissues, which are essential for the induction of skin and mucosal immunity and tolerance, including allergy. TGF-β1 has been confirmed to be a predominant factor involved in LC development. Despite great advances in the understanding of LC […]
Identification and characterization of DC-SIGN-binding glycoproteins in allergenic foods
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) is a C-type lectin receptor expressed on macrophages and dendritic cells. DC-SIGN has high affinity for fucosylated glycans in several plant glycoproteins and pathogens. DC-SIGN is thought to be crucial for development of allergic sensitization. However, the precise role of DC-SIGN in food allergy pathogenesis is […]
An increased prevalence of self-reported allergic rhinitis in major Chinese cities from 2005 to 2011
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background The prevalence of allergic rhinitis (AR) has increased worldwide in recent decades. The present study was conducted to investigate the prevalence of self-reported AR and profiles of AR-related comorbidities in the adult population of China over time. Methods This study surveyed residents of 18 major cities in mainland China. Telephone interviews were conducted […]
Absence of UCHL 1 function leads to selective motor neuropathy
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Abstract Objective The aim of this study was to investigate the role of ubiquitin C-terminal hydrolase-L1 (UCHL1) for motor neuron circuitry and especially in spinal motor neuron (SMN) health, function, and connectivity. Methods Since mutations in *UCHL1* gene leads to motor dysfunction in patients, we investigated the role of UCHL1 on SMN survival, axon health, and connectivity with the muscle, by employing molecular and cellular marker expression analysis and electrophysiological recordings, in healthy wild-type and *Uchl1**nm3419* (UCHL1−/−) mice, which lack all UCHL1 functio... περισσότερα »
Reliability of the axial vertebral rotation measurements of adolescent idiopathic scoliosis using the center of lamina method on ultrasound images: in vitro and in vivo study
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Abstract Purpose This study aimed to investigate the intra- and inter-observer reliability of the axial vertebral rotation (AVR) measurements of adolescent idiopathic scoliosis (AIS) using the center of lamina (COL) method on ultrasound transverse images. Methods Three cadaver vertebrae were scanned with 42 AVR configurations by both ultrasound and radiograph. In this in vitro study, four observers measured the AVR using the COL method on ultrasound transverse images and three observers measured the AVR using the Stokes' method on radiographs. In the in vivo study, 13 AIS subject... περισσότερα »
Cuff-leak test combined with interventional bronchoscopy benefits early extubation for patients who received tarp surgery
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Abstract Purpose This study explored the performance characteristics of a cuff-leak test (CLT) combined with interventional fiberoptic bronchoscopy (FBS) for evaluating whether early nasoendotracheal extubation was possible for patients who had received transoral atlantoaxial reduction plate (TARP) internal fixation surgery. Methods 318 patients who underwent surgery were retrospectively analyzed (between January 2006 and December 2012). Extubation was performed by conventional approach (CA group, until December 2008) and improved approach (IA group, from January 2009) including ... περισσότερα »
Normative values for the spine shape parameters using 3D standing analysis from a database of 268 asymptomatic Caucasian and Japanese subjects
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Abstract Purpose Sagittal balance analysis has gained importance and the measure of the radiographic spinopelvic parameters is now a routine part of many interventions of spine surgery. Indeed, surgical correction of lumbar lordosis must be proportional to the pelvic incidence (PI). The compensatory mechanisms [pelvic retroversion with increased pelvic tilt (PT) and decreased thoracic kyphosis] spontaneously reverse after successful surgery. Materials and methods This study is the first to provide 3D standing spinopelvic reference values from a large database of Caucasian (*n* = ... περισσότερα »
High D-dimer levels predict a poor outcome in patients with severe trauma, even with high fibrinogen levels on arrival: A multicenter retrospective study
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
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The Massive Transfusion Score as a decision aid for resuscitation: Learning when to turn the massive transfusion protocol on and off
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
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