Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Δευτέρα 7 Μαρτίου 2016

OtoRhinoLaryngology & Medicine,New Articles,March 8th,2016


Changes in macrophage function modulated by the lipid environment

Macrophages (Ms) play a critical role in the defense against pathogens, orchestrating the inflammatory response during injury and maintaining tissue homeostasis. During these processes, macrophages encounter a variety of environmental conditions that are likely to change their gene expression pattern, which modulates their function. In this study, we found that murine Ms displayed two different […]

Quality of life in patients with metastatic breast cancer treated with metronomic chemotherapy

Future Oncology Ahead of Print. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1p3XglC via IFTTT

Nodal metastases in thyroid cancer: prognostic implications and management

Future Oncology Ahead of Print. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1pclF9y via IFTTT

A PDGF-E2F-USP1-ID2 axis is required for proneural glioma

Glioblastoma (GBM) is the most aggressive primary brain tumor and responds poorly to currently available therapies. Transcriptomic characterization of GBM has identified distinct molecular subtypes of GBM. Gain-of-function alterations leading to enhanced platelet-derived growth factor (PDGF) signaling are commonly observed in the proneural subtype of GBM and can drive gliomagenesis. However, little is known about […]

C GAMP, Where Is Thy STING?

Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are required for the function of STING (TMEM173), an ER-resident transmembrane protein critical for cytoplasmic DNA sensing, IFN production, and cancer control. Here we show that the IRE-1/XBP-1 pathway functions downstream of STING and that STING agonists selectively trigger mitochondria-mediated apoptosis in normal and malignant B […]

Small cell mesothelioma: A rare entity and diagnostic pitfall mimicking small cell lung carcinoma on fine-needle aspiration

Small cell mesothelioma (SCM) is an extremely rare variant of epithelioid mesothelioma that can be mistaken for other forms of small round blue cell tumors, particularly small cell lung carcinoma (SCLC). Here, we describe a fine-needle aspiration (FNA) from a pleural lesion in a 75-year-old man with a history of known asbestos exposure. The FNA […]

Quality of life in patients with metastatic breast cancer treated with metronomic chemotherapy

Future Oncology Ahead of Print. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1p3XglC via IFTTT

Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, successfully treated by radical cystectomy with adjuvant chemotherapy: a case report

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 1 λεπτό
[image: s13256-016-0806-x-1.gif] Background: Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, is a rare histological type of bladder cancer similar to plasma cells and is an aggressive variant of urothelial carcinoma associated with a poor prognosis.Case presentationA 41-year-old Asian man was referred to our hospital due to macroscopic hematuria. Cystoscopy detected a non-papillary tumor, and a transurethral resection of the bladder tumor revealed pT1N0M0 bladder cancer. A pathological examination showed high-grade invasive urothelial carcinoma and a component of...περισσότερα »

Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 1 λεπτό
[image: s13256-016-0833-7-5.gif] Background: Malignant transformation of giant cell tumors of bones, that is, secondary malignant giant cell tumor of bone, is rare. The most common symptoms are local pain and swelling. There are no prior reports of giant cell tumor of bone with fever of unknown origin at the onset. Here we present a case of a secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin.Case presentationA 75-year-old Asian man presented with a 3-week history of co...περισσότερα »

Novel molecular processes controlling key genes in prostate cancer uncovered

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 3 δευτερόλεπτα
Researchers at Karolinska Institutet and the University of Oulu in Finland have elucidated gene regulatory mechanisms that can explain how known genetic variants influence prostate cancer risk. The findings, published in the journal Nature Genetics, reveal widespread deregulation of androgen receptor function, a key player in prostate cancer. The vast majority of the three billion base-pairs in the human genome are identical across individuals. Nevertheless, genome sequence variation that does occur in the population has a profound effect on an individual's predisposition for deve... περισσότερα »

Increased anticipatory contingent negative variation in posttraumatic stress disorder

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 3 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 7 March 2016 *Source:*Biological Psychology Author(s): Hongxia Duan, Li Wang, Guillén Fernández, Kan Zhang, Jianhui Wu Altered anticipation processes are implicated across various clinical samples, but few studies focused on the posttraumatic stress disorder (PTSD). We measured contingent negative variation (CNV) in a choice reaction paradigm among 58 survivors of the Wenchuan earthquake, including 28 individuals who were diagnosed with PTSD and 30 without PTSD. Compared to the non-PTSD group, the PTSD group had significantly ...περισσότερα »

Contamination of urinary cultures in initial-stream versus later-stream urine in children undergoing bladder catheterization for the diagnosis of urinary tract infection.

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Background: Urine cultures obtained by bladder catheterization can be contaminated by bacteria colonizing the distal urethra. Data are inconclusive regarding the potential advantage of discarding the first few urine drops obtained by bladder catheterization and testing only the sample of late-stream urine, thus reducing the likelihood of urine culture contamination. Aim: The aim of this study was to evaluate whether the incidence of contaminated urine cultures obtained by bladder catheterization can be reduced by splitting urine samples into 'initial' and 'late' samples and using on... περισσότερα »

Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, successfully treated by radical cystectomy with adjuvant chemotherapy: a case report


Background: Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, is a rare histological type of bladder cancer similar to plasma cells and is an aggressive variant of urothelial carcinoma associated with a poor prognosis.Case presentationA 41-year-old Asian man was referred to our hospital due to macroscopic hematuria. Cystoscopy detected a non-papillary tumor, and a transurethral resection of the […]

Steatocystoma simplex in penile foreskin: a case report


Background: Steatocystoma simplex is an uncommon skin lesion with a histological pattern that is identical to that of steatocystoma multiplex. We are reporting this case of steatocystoma simplex for its uncommon location in the penile foreskin, and its occurrence in a Wapishana man.Case presentationA 56-year-old man of Wapishana ethnicity presented with complaints of referred penile […]

Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report


Background: Malignant transformation of giant cell tumors of bones, that is, secondary malignant giant cell tumor of bone, is rare. The most common symptoms are local pain and swelling. There are no prior reports of giant cell tumor of bone with fever of unknown origin at the onset. Here we present a case of a […]

Hoogsteen-position pyrimidines promote the stability and function of the MALAT1 RNA triple helix REPORT


Triple-stranded RNA was first deduced to form in vitro more than 50 years ago and has since been implicated in RNA catalysis, stability, and small molecule binding. Despite the emerging biological significance of RNA triple helices, it remains unclear how their nucleotide composition contributes to their thermodynamic stability and cellular function. To investigate these properties, […]

Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, successfully treated by radical cystectomy with adjuvant chemotherapy: a case report


Background: Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, is a rare histological type of bladder cancer similar to plasma cells and is an aggressive variant of urothelial carcinoma associated with a poor prognosis.Case presentationA 41-year-old Asian man was referred to our hospital due to macroscopic hematuria. Cystoscopy detected a non-papillary tumor, and a transurethral resection of the […]

Reproductive alterations in hyperinsulinemic but normoandrogenic MSG-obese female rats


Obesity and metabolic syndrome are a common cause of reproductive and fertility disorders in women. In special, polycystic ovary syndrome, which is clinically characterized by hyperandrogenism, oligo/anovulation, and polycystic ovarian morphology, has been increasingly associated with metabolic disorders. However, given the broad interplay between metabolic and reproductive functions, this remains a field of intense research. […]

The deadenylase components Not2p, Not3p, and Not5p promote mRNA decapping REPORT


Decay of mRNA is essential for the efficient regulation of gene expression. A major pathway of mRNA degradation is initiated by the shortening of the poly(A) tail via the CCR4/NOT deadenylase complex. Deadenylation is followed by removal of the 5′ cap (i.e., decapping) and then 5′ to 3′ exonucleolytic decay of the message body. The […]

Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report


Background: Malignant transformation of giant cell tumors of bones, that is, secondary malignant giant cell tumor of bone, is rare. The most common symptoms are local pain and swelling. There are no prior reports of giant cell tumor of bone with fever of unknown origin at the onset. Here we present a case of a […]

Selectively enhanced photocurrent generation in twisted bilayer graphene with van Hove singularity

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα

Article Graphene has the high carrier mobility and short photoresponse time required for efficient photodetection, but broad and weak optical absorption are severe drawbacks. Here, the authors show that twisted bilayer graphene with van Hove singularities exhibits a strong light-matter interaction and selectively enhanced photocurrent generation. Nature Communications doi: 10.1038/ncomms10699 Authors: Jianbo Yin, Huan Wang,… Continue reading Selectively enhanced photocurrent generation in twisted bilayer graphene with van Hove singularity

Data publication with the structural biology data grid supports live analysis

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα

Article The validation and analysis of X-ray crystallographic data is essential for reproducibility and the development of crystallographic methods. Here, the authors describe a repository for crystallographic datasets and demonstrate some of the ways it could serve the crystallographic community. Nature Communications doi: 10.1038/ncomms10882 Authors: Peter A. Meyer, Stephanie Socias, Jason Key, Elizabeth Ransey, Emily… Continue reading Data publication with the structural biology data grid supports live analysis

CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα

Article CSF-contacting neurons are known to project to locomotor CPGs although their relevance to active locomotion is unclear. Here, the authors show that these cells constitute a mechanosensory organ relying on PKD2L1 channels to detect spinal cord curvature and modulate locomotor frequency in freely moving animals. Nature Communications doi: 10.1038/ncomms10866 Authors: Urs Lucas Böhm, Andrew… Continue reading CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits

Rule learning enhances structural plasticity of long-range axons in frontal cortex

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα

Article The orbitofrontal cortex is associated with foraging behaviour yet the structural changes underlying such rule-based learning remain unclear. Here, the authors imaged OFC axons throughout a digging-based odour discrimination task and found correlations between the rate of bouton turnover and the behavioural strategies of individual mice. Nature Communications doi: 10.1038/ncomms10785 Authors: Carolyn M. Johnson,… Continue reading Rule learning enhances structural plasticity of long-range axons in frontal cortex

Designing high-performance layered thermoelectric materials through orbital engineering

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα

Article Thermoelectric materials with enhanced performances need to be identified. Here, the authors use the crystal field splitting energy of orbitals as a descriptor to design thermoelectric materials by solid solution maps and strain engineering in layered CaAl 2 Si 2 -type Zintl compounds. Nature Communications doi: 10.1038/ncomms10892 Authors: Jiawei Zhang, Lirong Song, Georg K.… Continue reading Designing high-performance layered thermoelectric materials through orbital engineering

Cohort profile: the Spanish WORKing life Social Security (WORKss) cohort study

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα

Purpose The global economy is changing the labour market and social protection systems in Europe. The effect of both changes on health needs to be monitored in view of an ageing population and the resulting increase in prevalence of chronic health conditions. The Spanish WORKing life Social Security (WORKss) cohort study provides unique longitudinal data… Continue reading Cohort profile: the Spanish WORKing life Social Security (WORKss) cohort study

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα

Article Microglia play key roles during early neurodevelopment. Here the authors show that microglia are important mediators of ocular dominance plasticity (ODP). Microglia respond to monocular deprivation during the visual critical period, and disrupting microglial P2Y12 purinergic receptor abrogates ODP. Nature Communications doi: 10.1038/ncomms10905 Authors: G. O. Sipe, R. L. Lowery,, M-È Tremblay, E. A.… Continue reading Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

Nail dystrophy as the initial sign of multiple myeloma-associated systemic amyloidosis

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1Yq4Mnm via IFTTT

Reconstruction for Defects at the Base of the Philtrum Affecting the Upper Lip Vermilion.

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 28 δευτερόλεπτα
No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1QHVH4a via IFTTT

Commentary on Clinical and Histopathological Assessment of Facial Melasma After Low-fluence Q-switched Neodymium-doped Yttrium Aluminium Garnet Laser.

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 28 δευτερόλεπτα
No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1SwaNyn via IFTTT

Retrospective Review of Risk Factors Predictive of Complications in Patients After Below the Knee Mohs Micrographic Surgery.

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 28 δευτερόλεπτα
No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1QHVIVG via IFTTT

Contamination of urinary cultures in initial-stream versus later-stream urine in children undergoing bladder catheterization for the diagnosis of urinary tract infection.

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Background: Urine cultures obtained by bladder catheterization can be contaminated by bacteria colonizing the distal urethra. Data are inconclusive regarding the potential advantage of discarding the first few urine drops obtained by bladder catheterization and testing only the sample of late-stream urine, thus reducing the likelihood of urine culture contamination. Aim: The aim of this study was to evaluate whether the incidence of contaminated urine cultures obtained by bladder catheterization can be reduced by splitting urine samples into 'initial' and 'late' samples and using on... περισσότερα »

Paediatric workload of an adult retrieval service in Scotland.

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
The Emergency Medical Retrieval Service (EMRS) provides adults with life-threatening conditions in remote areas with timely interventions and rapid access to definitive medical care, including a primary response service. Paediatric patients are managed under a separate network. Despite this, there has been an increase in paediatric retrievals by EMRS. We aim to inform future service development and ascertain how EMRS can serve the needs of this cohort. This is a retrospective, observational study. Raw data were retrieved from the database of paediatric patients retrieved by EMRS for... περισσότερα »

IL-10 and HPV-/EBV-associated cancers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
IL-10 and HPV-/EBV-associated cancers: Kai Qu,1,* Qing Pang,1,* Ting Lin,1 Li Zhang,2 Mingliang Gu,3 Wenquan Niu,4 Chang Liu,1,* Ming Zhang5 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi Province, People’s Republic of China; 2Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China; 3Chinese Academy of Sciences Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy ...περισσότερα »

Advanced/Metastatic Soft Tissue Sarcoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Evolution of Randomized Trials in Advanced/Metastatic Soft Tissue Sarcoma: Endpoint Selection, Surrogacy, and Quality of Reporting [ORIGINAL REPORTS]: Purpose Randomized controlled trials (RCTs) in soft tissue sarcoma (STS) have used varying endpoints. The surrogacy of intermediate endpoints, such as progression-free survival (PFS), response rate (RR), and 3-month and 6-month PFS (3moPFS and 6moPFS) with overall survival (OS), remains unknown. The quality of efficacy and toxicity reporting in these studies is also uncertain. Methods A systematic review of systemic therapy RCTs in ...περισσότερα »

Advanced Melanoma Treated With Pembrolizumab

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Evaluation of Immune-Related Response Criteria and RECIST v1.1 in Patients With Advanced Melanoma Treated With Pembrolizumab [Immunotherapy]: Purpose We evaluated atypical response patterns and the relationship between overall survival and best overall response measured per immune-related response criteria (irRC) and Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST v1.1) in patients with advanced melanoma treated with pembrolizumab in the phase Ib KEYNOTE-001 study (clinical trial information: NCT01295827). Patients and Methods Patients received pembrolizumab 2 or ... περισσότερα »

Cardiovascular Disease Risk Profiles in Survivors of Adolescent and Young Adult (AYA) Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Cardiovascular Disease Risk Profiles in Survivors of Adolescent and Young Adult (AYA) Cancer: The Kaiser Permanente AYA Cancer Survivors Study [Epidemiology]: Purpose To describe the epidemiology and risk factors for cardiovascular disease (CVD) in survivors of adolescent and young adult (AYA) cancer. Methods We identified a retrospective cohort of 2-year survivors of AYA cancer who were diagnosed between the ages of 15 to 39 years (1998 to 2009) at Kaiser Permanente Southern California. A comparison group without cancer was selected and matched 10:1 to cancer survivors on the basi...περισσότερα »

Nodal metastases in thyroid cancer: prognostic implications and management

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Nodal metastases in thyroid cancer: prognostic implications and management: Future Oncology Ahead of Print. Laura Y Wang1 & Ian Ganly*,1 *Author for correspondence: ganlyi@mskcc.org The significance of cervical lymph node metastases in differentiated thyroid cancer has been controversial and continues to evolve. Current staging systems consider nodal metastases to confer a poorer prognosis, particularly in older patients. Increasingly, the literature suggests that characteristics of the metastatic lymph nodes such as size and number are also prognostic. There is a growing tre...περισσότερα »

Multimodal cancer care in poor prognosis cancers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Multimodal cancer care in poor prognosis cancers: Resection drives long-term outcomes: Background and Objectives Hospitals with high complex oncologic surgical volume have improved short-term outcomes. However, for long-term outcomes, the influence of other therapies must be considered. We compared effects of resection with other therapies on long-term outcomes across U.S. hospitals. Methods We examined claims in the Surveillance, Epidemiology, and End Results (SEER)-Medicare dataset for patients with esophageal (EC) and pancreatic (PC) cancers between 2005–2009, with follow-up thro... περισσότερα »

Effects of Prenatal Dexamethasone on the Pituitary Gland and Gonadotropic Cells in Female Offspring

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Effects of Prenatal Dexamethasone on the Rat Pituitary Gland and Gonadotropic Cells in Female Offspring: Glucocorticoids have a strong influence on growth and maturation of fetal organ systems, but overexposure to exogenous glucocorticoids may retard fetal growth and alter developmental processes in sensitive tissues. The aim of this study was to specifically determine whether prenatal exposure to dexamethasone (Dx) altered normal development and function of pituitary gonadotropic cells in neonatal, infant and peripubertal female offspring. On day 16 of pregnancy, rat dams received ...περισσότερα »

Myosin Heavy Chain Expression Can Vary over the Length of Jaw and Leg Muscles

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Myosin Heavy Chain Expression Can Vary over the Length of Jaw and Leg Muscles: Muscle fiber type classification can be determined by its myosin heavy chain (MyHC) composition based on a few consecutive sections. It is generally assumed that the MyHC expression of a muscle fiber is the same over its length since neural stimulation and systemic influences are supposed to be the same over its length. We analyzed this in detail in three muscle types: the temporalis (closer) and digastricus (opener; both first brachial arch), and the medial gastrocnemius (somite). Sections of the muscles...περισσότερα »

Do epinephrine auto-injectors have an unsuitable needle length in children and adolescents at risk for anaphylaxis from food allergy?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Do epinephrine auto-injectors have an unsuitable needle length in children and adolescents at risk for anaphylaxis from food allergy?: Food allergy is the most common cause of anaphylaxis in children. Intramuscular delivery of epinephrine auto-injectors (EAI) is the standard of care for the treatment of anaphylaxis. We examined if children an... Sten Dreborg, Xia Wen, Laura Kim, Gina Tsai, Immaculate Nevis, Ryan Potts, Jack Chiu, Arunmozhi Dominic and Harold KimEmail author Allergy, Asthma & Clinical Immunology201612:11 DOI: 10.1186/s13223-016-0110-8© Dreborg et al. 2016 Rece...περισσότερα »

Changes in macrophage function modulated by the lipid environment

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Changes in macrophage function modulated by the lipid environment: Macrophages (Ms) play a critical role in the defense against pathogens, orchestrating the inflammatory response during injury and maintaining tissue homeostasis. During these processes, macrophages encounter a variety of environmental conditions that are likely to change their gene expression pattern, which modulates their function. In this study, we found that murine Ms displayed two different subpopulations characterized by differences in morphologies, expression of surface markers and phagocytic capacity under no...περισσότερα »

Diabetic osteomyelitis : Erythrocyte sedimentation rate and C-reactive protein to monitor treatment outcomes

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Erythrocyte sedimentation rate and C-reactive protein to monitor treatment outcomes in diabetic foot osteomyelitis: Abstract This study sought to evaluate the effectiveness of the inflammatory markers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), in monitoring treatment of osteomyelitis in the diabetic foot. We screened 150 charts of patients admitted to our hospital with diabetic foot osteomyelitis (DFO), confirmed by positive results of bone culture and/or histopathology. We included patients who had an initial ESR/CRP within 72 hours of admission and two re... περισσότερα »

Dendritic cells generated from peripheral blood monocytes (Mo-DCs) and stimulated with laryngeal cancer cell lysates are not good enough in stimulating anti-tumor immunity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Dendritic cells generated from peripheral blood monocytes (Mo-DCs) and stimulated with laryngeal cancer cell lysates are not good enough in stimulating anti-tumor immunity: The use of immunotherapy as an adjuvant traditional treatment could prevent metastasis and give a chance for longer survival of cancer patients. It is known that the dendritic cells are the most effective antigen presenting cells (APC) and are the only APCs which activate innate T cells, therefore, they may involve additional forces to attack the cancerous cells [3]. The purpose of the use of immunotherapy is to ... περισσότερα »

Une cellulite nécrosante cervicale révélant un syndrome de Lemierre

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Une cellulite nécrosante cervicale révélant un syndrome de Lemierre via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 7 March 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): C. Assouan, A. Salami, E. Anzouan-Kacou, N. Nguessan, E. Konan IntroductionLe syndrome de Lemierre est caractérisé par une thrombophlébite septique de la veine jugulaire interne (VJI) consécutive le plus souvent à une infection oropharyngée.Cas cliniqueNous rapportons un cas de syndrome de Lemierre surv...περισσότερα »

Spatial plasticity of the auditory cortex in single-sided deafness

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 36 δευτερόλεπτα
[image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis To evaluate spatial plasticity of the auditory cortex in single-sided deafness (SSD). Study Design Cross-sectional study comparing a cohort with adult-onset, idiopathic SSD to a cohort with normal hearing. Methods Demographic, audiometric, magnetoencephalographic imaging, and magnetic resonance imaging data were collected for 13 SSD adult subjects and 13 normal-hearing controls. Locations of peak activation corresponding to the M100 response in auditory cortices ipsilateral and contralateral to tonal stimu...περισσότερα »

Utilisation de la hyaluronidase pour la correction des injections d’acide hyaluronique en médecine esthétique

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
Utilisation de la hyaluronidase pour la correction des injections d’acide hyaluronique en médecine esthétique via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 7 March 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): C. Lacoste, B. Hersant, R. Bosc, W. Noel, J.P. Meningaud L’acide hyaluronique (AH) est le produit de comblement le plus utilisé en médecine esthétique. Cependant une surcorrection peut survenir même aux mains de praticiens expérimentés. La hyaluronidase est une... περισσότερα »

Oral erosions and ulcers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
Atteinte plurifocale de syphilis secondaire : présentation d’un cas via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 7 March 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): F. Campana, J. Carvelli, J.C. Fricain, B. Vergier, F. Boralevi, G. Kaplanski IntroductionLa syphilis est une infection sexuellement transmissible (IST) liée au Treponema pallidum. La syphilis secondaire correspond à la diffusion systémique hématogène du tréponème.ObservationNous rapportons un cas de sy...περισσότερα »

Spatial plasticity of the auditory cortex in single-sided deafness


Objectives/Hypothesis To evaluate spatial plasticity of the auditory cortex in single-sided deafness (SSD). Study Design Cross-sectional study comparing a cohort with adult-onset, idiopathic SSD to a cohort with normal hearing. Methods Demographic, audiometric, magnetoencephalographic imaging, and magnetic resonance imaging data were collected for 13 SSD adult subjects and 13 normal-hearing controls. Locations of peak activation […]

Reproductive alterations in hyperinsulinemic but normoandrogenic MSG-obese female rats


Obesity and metabolic syndrome are a common cause of reproductive and fertility disorders in women. In special, polycystic ovary syndrome, which is clinically characterized by hyperandrogenism, oligo/anovulation, and polycystic ovarian morphology, has been increasingly associated with metabolic disorders. However, given the broad interplay between metabolic and reproductive functions, this remains a field of intense research. […]

Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, successfully treated by radical cystectomy with adjuvant chemotherapy: a case report


Background: Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, is a rare histological type of bladder cancer similar to plasma cells and is an aggressive variant of urothelial carcinoma associated with a poor prognosis.Case presentationA 41-year-old Asian man was referred to our hospital due to macroscopic hematuria. Cystoscopy detected a non-papillary tumor, and a transurethral resection of the […]

Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report


Background: Malignant transformation of giant cell tumors of bones, that is, secondary malignant giant cell tumor of bone, is rare. The most common symptoms are local pain and swelling. There are no prior reports of giant cell tumor of bone with fever of unknown origin at the onset. Here we present a case of a […]

Steatocystoma simplex in penile foreskin: a case report


Background: Steatocystoma simplex is an uncommon skin lesion with a histological pattern that is identical to that of steatocystoma multiplex. We are reporting this case of steatocystoma simplex for its uncommon location in the penile foreskin, and its occurrence in a Wapishana man.Case presentationA 56-year-old man of Wapishana ethnicity presented with complaints of referred penile […]

Use of a knowledge-attitude-behaviour education programme for Chinese adults undergoing maintenance haemodialysis: Randomized controlled trial


Objective To investigate the effects of a knowledge-attitude-behaviour health education model on acquisition of disease-related knowledge and self-management behaviour by patients undergoing maintenance haemodialysis. Methods Patients recently prescribed MHD were randomly assigned to a control group or an intervention group. Control group patients were treated with usual care and general education models. A specialist knowledge-attitude-behaviour […]

Inequity Leads to Distress and a Reduction in Satisfaction: Evidence From a Priming Experiment


Considerable research has shown that perceptions of inequity in relationships are associated with distress and relationship dissatisfaction, thus providing support for equity theory’s predictions. The evidence, however, is based primarily on correlational data, making it difficult to determine causality. The reverse causal direction could also explain the correlational findings—dissatisfaction could lead to perceptions of inequity. […]

Patient-Reported Outcomes After Choice for Contralateral Prophylactic Mastectomy Surgical Oncology


Purpose The rate of contralateral prophylactic mastectomies (CPMs) continues to rise, although there is little evidence to support improvement in quality of life (QOL) with CPM. We sought to ascertain whether patient-reported outcomes and, more specifically, QOL differed according to receipt of CPM. Methods Volunteers recruited from the Army of Women with a history of […]

Impact of Subsequent Therapies on Outcome of the FIRE-3/AIO KRK0306 Trial CORRESPONDENCE


from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OYaEwW via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel:00302841026182 & 00306932607174

Is Estradiol Monitoring Necessary in Women Receiving Ovarian Suppression for Breast Cancer? ONCOLOGY GRAND ROUNDS


The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers […]

Harlequin's syndrome is a neurological disorder due to a dysfunction of the sympathetic innervation of the face

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Syndrome d’Arlequin chez un patient mélanoderme via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 7 March 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): C. Assouan, A. Salami, A. Kadre, N.D. N’guessan, E. Anzouan-Kacou, E. Konan IntroductionLe syndrome d’Arlequin est un trouble neurologique de topographie faciale, lié à une dysfonction de l’innervation sympathique de la face. Il est rarement décrit dans la littérature. Les auteurs décrivent un cas observé chez un sujet mé... περισσότερα »

Localisation palatine d’une maladie de Kimura

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Localisation palatine d’une maladie de Kimura via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 7 March 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): L. Benslama, D. Labrousse, F. Gruffaz, P. Goudot IntroductionLa maladie de Kimura est une affection inflammatoire auto-immune endémique dans les pays du Moyen-Orient et d’Asie, rare en Europe. Habituellement, l’atteinte cervico-faciale se manifeste par des lésions sous-cutanées nodulaires associées à des adénopathies cervica...περισσότερα »

Haemostatic property of cyanoacrylate in pedicled flaps

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Haemostatic property of cyanoacrylate in pedicled flaps via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 7 March 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): John Michael Ranson, Kavit Amin, Eyal M.M. Schechter, Damir Kosutic We present a technique that can, in principle, be applied to any pedicled flap that is routinely used for reconstructions of the forehead. In our experience, cyanoacrylate glue applied to the pedicle before the flap is inserted decreases postoperative bleeding and wound exudate.

An Injectable for Cartilage Regeneration

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Fibrin Hydrogels Functionalized with Particulated Cartilage Extracellular Matrix and Incorporating Freshly Isolated Stromal Cells as an Injectable for Cartilage Regeneration via Acta Biomaterialia Publication date: Available online 4 March 2016 *Source:*Acta Biomaterialia Author(s): H.V. Almeida, R. Eswaramoorthy, G.M. Cunniffe, C.T. Buckley, F.J. O’Brien, D.J. Kelly Freshly isolated stromal cells can potentially be used as an alternative to in vitro expanded cells in regenerative medicine. Their use requires the development of bioactive hydrogels or scaffolds which provide an environ... περισσότερα »

Anti-biofouling interface on hydroxyapatite surface by coating zwitterionic MPC polymer containing calcium-binding moieties to prevent oral bacterial adhesion

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Development of via Acta Biomaterialia Publication date: Available online 4 March 2016 *Source:*Acta Biomaterialia Author(s): Sunah Kang, Myoungjin Lee, Minji Kang, Minwoo Noh, Joohee Jeon, Yan Lee, Ji-Hun Seo The purpose of the present study is to synthesize a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer capable of being immobilized on the tooth surface to prevent oral bacterial adhesion. The strategy is to develop an MPC-based polymer with Ca2+-binding moieties, i.e., phosphomonoester groups, for stronger binding with hydroxyapatite (HA) of the tooth surface. To this end, ... περισσότερα »

Copper-containing bioactive glass/eggshell membrane nanocomposites for improving angiogenesis, antibacterial activity and wound healing

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Preparation of via Acta Biomaterialia Publication date: Available online 7 March 2016 *Source:*Acta Biomaterialia Author(s): Jinyan Li, Dong Zhai, Fang Lv, Qingqing Yu, Hongshi Ma, Jinbo Yin, Zhengfang Yi, Mingyao Liu, Jiang Chang, Chengtie Wu Effectively stimulating angiogenesis and avoiding wound infection are great challenges in wound care management. Designing new healing dressings with requisite angiogenic capacity and antibacterial performance is of particular significance. In order to achieve this aim, we prepared a copper (Cu)-containing bioactive glass nanocoating (40-50 nm) ... περισσότερα »

Sleep-disordered breathing in orthodontic practice

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
Sleep-disordered breathing in orthodontic practice: Abstract ObjectivesThe purpose of this work was to evaluate the prevalence of snoring and its correlation with cranial and upper airway morphology in young individuals with orthodontic treatment need. Patients and methodsParents of 379 children were consecutively interviewed, using eight questions from a more comprehensive questionnaire about sleep behavior. A total of 100 patients (54 girls, 46 boys, average age 11.3 years) met the inclusion criteria. Based on the parents’ interviews, the sample was divided into snorers (*n* ... περισσότερα »

Aided Electrophysiology Using Direct Audio Input: Effects of Amplification and Absolute Signal Level

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
Aided Electrophysiology Using Direct Audio Input: Effects of Amplification and Absolute Signal Level: Purpose This study investigated (a) the effect of amplification on cortical auditory evoked potentials (CAEPs) at different signal levels when signal-to-noise ratios (SNRs) were equated between unaided and aided conditions, and (b) the effect of absolute signal level on aided CAEPs when SNR was held constant. Method CAEPs were recorded from 13 young adults with normal hearing. A 1000-Hz pure tone was presented in unaided and aided conditions with a linear analog hearing aid. Dire... περισσότερα »

Craniofacial and Dental Defects in the Col1a1Jrt/+ Mouse Model of Osteogenesis Imperfecta

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 45 δευτερόλεπτα
Certain mutations in the *COL1A1* and *COL1A2* genes produce clinical symptoms of both osteogenesis imperfecta (OI) and Ehlers-Danlos syndrome (EDS) that include abnormal craniofacial growth, dental malocclusion, and dentinogenesis imperfecta. A mouse model (*Col1a1Jrt/+*) was recently developed that had a skeletal phenotype and other features consistent with moderate-to-severe OI and also with EDS. The craniofacial phenotype of 4- and 20-wk-old *Col1a1Jrt/+* mice and wild-type littermates was assessed by micro–computed tomography (µCT) and morphometry. Teeth and the periodontal l... περισσότερα »

Online Tone Generator

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Online Tone Generator: Tinnitus is a medical condition in which a person hears a sound from within their ears, but there is no external sound present in the environment. This auto-generated sound may occur only at certain times, such as when the person is under stress, or it may be an all day and all night long experience. If you have tinnitus, there are treatment options that may help to lessen your symptoms. An online tone generator for tinnitus is one convenient way to take control of tinnitus and regain your sense of hearing. Types of Tinnitus Tones Tinnitus is not a disease i... περισσότερα »

Functional imaging in migraine.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα

Functional imaging in migraine.: Afridi, S.K.; (2005) Functional imaging in migraine. Doctoral thesis, University of London. Green open access Afridi, S.K.; (2005) Functional imaging in migraine. Doctoral thesis, University of London. [image: Green open access] [image: [img]] Text U592564.pdf Download (7MB) Abstract Migraine is a common disabling condition likely to be associated with dysfunction of brain pathways involved in pain and other sensory modalities. Functional brain imaging in acute migraine has proved challenging due to the logistic problems associated with ... περισσότερα »

Characterization of Candida species of the mouth

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα

Characterization of Candida species of the mouth in healthy patients and following bone marrow transplantations.: Al-Karaawi, Z.; (2005) Characterization of Candida species of the mouth in healthy patients and following bone marrow transplantations. Doctoral thesis, University of London. Green open access Al-Karaawi, Z.; (2005) Characterization of Candida species of the mouth in healthy patients and following bone marrow transplantations. Doctoral thesis, University of London. [image: Green open access] [image: [img]] Text U592576 Redacted.PDF Download (12MB) Abstract ... περισσότερα »

The Mechanics of Brow-suspension Ptosis Repair

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
*The Mechanics of Brow-suspension Ptosis Repair: A Comparative Study of Fox Pentagon and Crawford Triangle Techniques.: Kwon, KA; Shipley, RJ; Edirisinghe, M; Best, SM; Cameron, RE; Poitelea, C; Rose, GE; Kwon, KA; Shipley, RJ; Edirisinghe, M; Best, SM; Cameron, RE; Poitelea, C; Rose, GE; Ezra, DG; - view fewer (2016) The Mechanics of Brow-suspension Ptosis Repair: A Comparative Study of Fox Pentagon and Crawford Triangle Techniques. Ophthal Plast Reconstr Surg 10.1097/IOP.0000000000000621 . * *Kwon, KA; Shipley, RJ; Edirisinghe, M; Best, SM; Cameron, RE; Poitelea, C; Rose, GE;... περισσότερα »

Materials & Design

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Submicron lamellar porous structure formed by selective dissolution of Ti-Al alloy Publication date: 15 May 2016 *Source:*Materials & Design, Volume 98 Author(s): Dai-Xiu Wei, Yuichiro Koizumi, Yunping Li, Kenta Yamanak, Akihiko Chiba We created high-aspect-ratio sub-micron-sized lamellar porous structure by simple anodic selective dissolution of lamellar Ti-Al alloy in NaCl aqueous solution. The geometries of lamellar structures, which determined those of lamellar porous structure, were controlled by hot forging and subsequent ageing treatment before dissolution process. Altho... περισσότερα »

Fabrication of bespoke nasal septal scaffolds

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
*Fabrication of bespoke nasal septal scaffolds: Hashimdeen, SH; Thorogate, R; Miodownik, M; Edirisinghe, MJ; (2016) Fabrication of bespoke nasal septal scaffolds. MATERIALS & DESIGN , 90 pp. 403-409. 10.1016/j.matdes.2015.10.120 . * Highlights *•* *Electrohydrodynamic (EHD) printing of polymeric nasal septal scaffolds was performed.* *•* *A special EHD desktop-printer with replication rapid prototyping technology was used.* *•* *Polymer concentration was varied to create three distinct scaffold architectures.* *•* *Nanomechanical mapping was used to assess scaffold deformation and... περισσότερα »

Robotics in otolaryngology and head and neck surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Robotics in otolaryngology and head and neck surgery: Recommendations for training and credentialing: A report of the 2015 AHNS education committee, AAO-HNS robotic task force and AAO-HNS sleep disorders committee: Abstract Training and credentialing for robotic surgery in otolaryngology - head and neck surgery is currently not standardized, but rather relies heavily on industry guidance. This manuscript represents a comprehensive review of this increasingly important topic and outlines clear recommendations to better standardize the practice. The recommendations provided can be use...περισσότερα »

Acute sinusitis complicated by subperiosteal abscess in children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Microbiology and choice of antimicrobial therapy for via International Journal of Pediatric Otorhinolaryngology Publication date: May 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 84 Author(s): Itzhak Brook ObjectivesReview past studies of the microbiology of subperiosteal abscesses (SPOA) complicating sinusitis in children and their implications of the antimicrobials administered to treat the infection.MethodsLiterature search was conducted of the Cochrane Library, EMBASE, TRIP, EMBASE, and MEDLINE databases from their inception.ResultsThe most common pa...περισσότερα »

Hearing loss in urban school children (grade 1 to 3)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
Hearing loss in urban South African school children (grade 1 to 3) via International Journal of Pediatric Otorhinolaryngology Publication date: May 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 84 Author(s): Faheema Mahomed-Asmail, De Wet Swanepoel, Robert H. Eikelboom ObjectiveThis study aimed to describe the prevalence and characteristics of hearing loss in school-aged children in an urban South African population.MethodChildren from grade one to three from five schools in the Gauteng Province of South Africa formed a representative sample for this study...περισσότερα »

Cinnamaldehyde is an effective anti-inflammatory agent for treatment of allergic rhinitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
in a rat model via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 7 March 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Deniz Hancı, Hüseyin Altun, Erdem Atalay Çetinkaya, Nuray Bayar Muluk, Betül Peker Cengiz, Cemal Cingi ObjectivesThe effect of cinnamaldehyde on the treatment of allergic rhinitis (AR) was investigated in rat model.MethodsTwenty-eight female Wistar albino rats were randomly divided into four groups: Group 1 (control) (C), Group 2 (AR with no treatment) (AR+NoTr), Group 3 (AR+Azelastine HCl) ...περισσότερα »

Age- and Gender-Related Mean Hearing Threshold in a Highly-Screened Population

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
Age- and Gender-Related Mean Hearing Threshold in a Highly-Screened Population: The Korean National Health and Nutrition Examination Survey 2010–2012: by Yun Hwi Park, Seung-Ho Shin, Sung Wan Byun, Ju Yeon Kim Background In evaluating hearing disability in medicolegal work, the apportionment of age- and gender-related sensorineural hearing loss should be considered as a prior factor, especially for the elderly. However, in the literature written in the English language no studies have reported on the age- and gender-related mean hearing threshold for the South Korean population. ...περισσότερα »

Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα

Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers: [image: access_no.gif] Thyroid , Vol. 0, No. 0. Author information Patricia Aragon Han,1 Hyun-seok Kim,1 Soonweng Cho,1 Roghayeh Fazeli,1 Alireza Najafian,1 Hunain Khawaja,1 Melissa McAlexander,2 Benzon Dy,3 Meredith Sorensen,4 Anna Aronova,5 Thomas J. Sebo,6Thomas J. Giordano,7 Thomas J. Fahey III,5 Geoffrey B. Thompson,3 Paul G. Gauger,4 Helina Somervell,1 Justin A. Bishop,8 James R. Eshleman,8 Eric ...περισσότερα »

Patterns of lymphatic spread and the management of eyelid carcinomas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Patterns of lymphatic spread and the management of eyelid carcinomas: Eyelid carcinomas are rare, and the management strategy of regional lymph node metastasis linked to eyelid carcinomas has not been standardized to date. The aim of the present study was to analyze the patterns of regional metastasis and to assess the optimal extent of surgical treatment for lymph node metastasis of eyelid carcinoma. AbstractObjective Eyelid carcinomas are rare, and the management strategy of regional lymph node metastasis linked to eyelid carcinomas has not been standardized to date. The aim of... περισσότερα »

External Validation of the Acoustic Voice Quality Index Version 03.01 With Extended Representativity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
External Validation of the Acoustic Voice Quality Index Version 03.01 With Extended Representativity: Objectives: The Acoustic Voice Quality Index (AVQI) is an objective method to quantify the severity of overall voice quality in concatenated continuous speech and sustained phonation segments. Recently, AVQI was successfully modified to be more representative and ecologically valid because the internal consistency of AVQI was balanced out through equal proportion of the 2 speech types. The present investigation aims to explore its external validation in a large data set. Methods: ...περισσότερα »

Craniofacial and Dental Defects in the Osteogenesis Imperfecta

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Craniofacial and Dental Defects in the Col1a1Jrt/+ Mouse Model of Osteogenesis Imperfecta: Certain mutations in the *COL1A1* and *COL1A2* genes produce clinical symptoms of both osteogenesis imperfecta (OI) and Ehlers-Danlos syndrome (EDS) that include abnormal craniofacial growth, dental malocclusion, and dentinogenesis imperfecta. A mouse model (*Col1a1Jrt/+*) was recently developed that had a skeletal phenotype and other features consistent with moderate-to-severe OI and also with EDS. The craniofacial phenotype of 4- and 20-wk-old *Col1a1Jrt/+* mice and wild-type littermates wa... περισσότερα »

Hoogsteen-position pyrimidines promote the stability and function of the MALAT1 RNA triple helix [REPORT]

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
Triple-stranded RNA was first deduced to form in vitro more than 50 years ago and has since been implicated in RNA catalysis, stability, and small molecule binding. Despite the emerging biological significance of RNA triple helices, it remains unclear how their nucleotide composition contributes to their thermodynamic stability and cellular function. To investigate these properties, we used in vitro RNA electrophoretic mobility shift assays (EMSAs) and in vivo intronless β-globin reporter assays to measure the relative contribution of 20 RNA base triples (N•A–U, N•G–C, N•C–G, N•U–...περισσότερα »

The deadenylase components Not2p, Not3p, and Not5p promote mRNA decapping [REPORT]

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
Decay of mRNA is essential for the efficient regulation of gene expression. A major pathway of mRNA degradation is initiated by the shortening of the poly(A) tail via the CCR4/NOT deadenylase complex. Deadenylation is followed by removal of the 5' cap (i.e., decapping) and then 5' to 3' exonucleolytic decay of the message body. The highly conserved CCR4/NOT deadenylase complex consists of the exonucleases CCR4 and POP2/CAF1, as well as a group of four or five (depending on organism) accessory factors of unknown function, i.e., the NOT proteins. In this study, we find that *Saccharo...περισσότερα »

Cohort profile: the Spanish WORKing life Social Security (WORKss) cohort study

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
Purpose The global economy is changing the labour market and social protection systems in Europe. The effect of both changes on health needs to be monitored in view of an ageing population and the resulting increase in prevalence of chronic health conditions. The Spanish WORKing life Social Security (WORKss) cohort study provides unique longitudinal data to study the impact of labour trajectories and employment conditions on health, in terms of sickness absence, permanent disability and death. Participants The WORKss cohort originated from the Continuous Working Life Sample (CWL...περισσότερα »

Cross-sectional study examining whether the extent of first-contact access to primary care differentially benefits those with certain personalities to receive preventive services

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
Objective The extent of first-contact access to primary care (ie, easy availability when needed) is associated with receiving recommended preventive services. Whether this access benefits patients at risk of preventive services underutilisation, such as those with certain personality characteristics, is unclear. Setting Secondary analysis of the 2003–2006 round of the Wisconsin Longitudinal Study. Participants 6975 respondents who reported a usual provider whose specialty was internal medicine or family medicine. Those reporting not visiting a medical provider in the past 12 ... περισσότερα »

Post-traumatic stress disorder and occupational characteristics of police officers in Republic of Korea: a cross-sectional study

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
Objective South Korean police officers have a greater workload compared to their counterparts in advanced countries. However, few studies have evaluated the occupational challenges that South Korean police officers face. Therefore, this study aimed to evaluate the police officer's job characteristics and risk of post-traumatic stress disorder (PTSD) among South Korean police officers. Design Cross-sectional study. Setting Police officers in South Korea. Participants 3817 police officers with a traumatic event over a 1-year period. Main outcome measures Officers with a respo... περισσότερα »

Gender-informed, psychoeducational programme for couples to prevent postnatal common mental disorders among primiparous women: cluster randomised controlled trial

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
Objectives Interventions to prevent postpartum common mental disorders (PCMD) among unselected populations of women have had limited success. The aim was to determine whether What Were We Thinking (WWWT) a gender-informed, psychoeducational programme for couples and babies can prevent PCMD among primiparous women 6 months postpartum. Design Cluster-randomised controlled trial. Setting 48 Maternal and Child Health Centres (MCHCs) from 6 Local Government Areas in Melbourne, Australia were allocated randomly to usual care (24) or usual care plus WWWT (24). Participants English-... περισσότερα »

Effect of posterior decompression extent on biomechanical parameters of the spinal cord in cervical ossification of the posterior longitudinal ligament

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
Ossification of the posterior longitudinal ligament is a common cause of the cervical myelopathy due to compression of the spinal cord. Patients with ossification of the posterior longitudinal ligament usually require the decompression surgery, and there is a need to better understand the optimal surgical extent with which sufficient decompression without excessive posterior shifting can be achieved. However, few quantitative studies have clarified this optimal extent for decompression of cervical ossification of the posterior longitudinal ligament. We used finite element modeling... περισσότερα »

Cycle time influences the development of muscle fatigue at low to moderate levels of intermittent muscle contraction

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
Publication date: Available online 8 March 2016 *Source:*Journal of Electromyography and Kinesiology Author(s): Ehsan Rashedi, Maury A. Nussbaum Localized muscle fatigue (LMF) during a repetitive task can be influenced by several aspects such as the level and duration of exertions. Among these aspects, though, the influence of cycle time remains unclear. Here, the effect of cycle time on LMF and performance was examined for a simple biomechanical system during repetitive static efforts. Participants performed 1-hour trials of intermittent isometric index finger abduction with a duty... περισσότερα »

Prostate cancer - evidence of exercise and nutrition trial (PrEvENT): study protocol for a randomised controlled feasibility trial

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
A growing body of observational evidence suggests that nutritional and physical activity interventions are associated with beneficial outcomes for men with prostate cancer, including brisk walking, lycopene in... from #Medicine via ola Kala on Inoreader http://ift.tt/1R4jZec Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Rectal indomethacin alone versus indomethacin and prophylactic pancreatic stent placement for preventing pancreatitis after ERCP: study protocol for a randomized controlled trial

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
The combination of prophylactic pancreatic stent placement (PSP) – a temporary plastic stent placed in the pancreatic duct – and rectal non-steroidal anti-inflammatory drugs (NSAIDs) is recommended for prevent... from #Medicine via ola Kala on Inoreader http://ift.tt/1p3P2Kg Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Online Tone Generator

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
Tinnitus is a medical condition in which a person hears a sound from within their ears, but there is no external sound present in the environment. This auto-generated sound may occur only at certain times, such as when the person is under stress, or it may be an all day and all night long experience. If you have tinnitus, there are treatment options that may help to lessen your symptoms. An online tone generator for tinnitus is one convenient way to take control of tinnitus and regain your sense of hearing. Types of Tinnitus Tones Tinnitus is not a disease in and of itself, but ins... περισσότερα »

Autogenous fascia lata sling versus Gore Tex suspension

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
Elsamkary MA, Roshdy MM from #Medicine via ola Kala on Inoreader http://ift.tt/1X8th7c Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Vitamin D Status and Supplementation in the Critically Ill

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
Abstract Vitamin D deficiency has recently been recognized as a widespread global disorder. Generally considered a direct extension of malnutrition, even subclinical hypovitaminosis D is now recognized in adequately nourished populations. Compared to the general population, the prevalence of hypovitaminosis D is greater in the critically ill population. In fact, several studies have shown poorer outcomes in critically ill patients discovered to be vitamin D deficient or insufficient. Controversy persists regarding vitamin D measurements, quantity of supplementation, and appropriat... περισσότερα »

Gastrointestinal Disorders Associated with Common Variable Immune Deficiency (CVID) and Chronic Granulomatous Disease (CGD)

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
Abstract Common variable immune deficiency (CVID) and chronic granulomatous disease (CGD) are two of the well-characterized primary immune deficiencies with distinct pathologic defects. While CVID is predominantly a disorder of the adaptive immune system, in CGD, innate immunity is impaired. In both syndromes, the clinical manifestations include an increased susceptibility to infections and a number of non-infectious, inflammatory conditions including systemic autoimmunity, as well as organ-specific pathology. Among the organ-associated disorders, gastrointestinal (GI) manifestatio... περισσότερα »

Small Bowel Congenital Anomalies: a Review and Update

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
Abstract The small intestine is a complex organ system that is vital to the life of the individual. There are a number of congenital anomalies that occur and present most commonly in infancy; however, some may not present until adulthood. Most congenital anomalies of the small intestine will present with obstructive symptoms while some may present with vomiting, abdominal pain, and/or gastrointestinal bleeding. Various radiologic procedures can aid in the diagnosis of these lesions that vary depending on the particular anomaly. Definitive therapy for these congenial anomalies is su... περισσότερα »

Electrochemical Study and Applications of Selective Electrodeposition of Silver on Quantum Dots

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b04568 [image: ancham?d=yIl2AUoC8zA] from #Medicine via ola Kala on Inoreader http://ift.tt/1QHnth9 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Determination of Bromine Stable Isotope Ratios from Saline Solutions by “Wet Plasma” MC-ICPMS Including a Comparison between High- and Low-Resolution Modes, and Three Introduction Systems

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.6b00062 [image: ancham?d=yIl2AUoC8zA] from #Medicine via ola Kala on Inoreader http://ift.tt/1QHnt0M Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Femtosecond lasers for LASIK

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 56 δευτερόλεπτα
Huhtala A, Pietilä J, Mäkinen P, Uusitalo H from #Medicine via ola Kala on Inoreader http://ift.tt/1R3XFBo Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Solid-type primary intraosseous squamous-cell carcinoma in the mandible: Report of a rare case

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 16 January 2016 Source:Hematology/Oncology and Stem Cell Therapy Author(s): Ohoud Alotaibi, Nabil Al-Zaher, Faiza Alotaibi, Hatim Khoja, Ahmed Qannam Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant neoplasm that has an exquisitely exclusive affection to the jawbone. It is defined as squamous cell carcinoma arising within the jaw and developing from residual odontogenic epithelium or from a preexisting odontogenic cyst or tumor. The solid-type of this tumor is a central jaw carcinoma arising de novo and has no initial con... περισσότερα »

Solid-type primary intraosseous squamous-cell carcinoma in the mandible: Report of a rare case

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 16 January 2016 Source:Hematology/Oncology and Stem Cell Therapy Author(s): Ohoud Alotaibi, Nabil Al-Zaher, Faiza Alotaibi, Hatim Khoja, Ahmed Qannam Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant neoplasm that has an exquisitely exclusive affection to the jawbone. It is defined as squamous cell carcinoma arising within the jaw and developing from residual odontogenic epithelium or from a preexisting odontogenic cyst or tumor. The solid-type of this tumor is a central jaw carcinoma arising de novo and has no initial con... περισσότερα »

Preoperative NLR and PLR in the middle or lower ESCC patients with radical operation

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) had been analysed in many kind of tumours, but its role of predict the oesophageal squamous cell carcinoma (ESCC) patients' prognosis was not reach a consensus. Relationship between NLR, PLR and ESCC located in the middle or lower segment was evaluated. 317 patients with ESCC who underwent attempted curative oesophagectomy were analysed in this study. 157 and 98 patients had elevated NLR and PLR respectively (NLR >3.3 and PLR >150). The median overall survival time (OS) and disease‐free survival (DFS) was 34.1 a... περισσότερα »

Patient-Reported Outcomes After Choice for Contralateral Prophylactic Mastectomy Surgical Oncology

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Purpose The rate of contralateral prophylactic mastectomies (CPMs) continues to rise, although there is little evidence to support improvement in quality of life (QOL) with CPM. We sought to ascertain whether patient-reported outcomes and, more specifically, QOL differed according to receipt of CPM. Methods Volunteers recruited from the Army of Women with a history of… Continue reading Patient-Reported Outcomes After Choice for Contralateral Prophylactic Mastectomy Surgical Oncology

Inequity Leads to Distress and a Reduction in Satisfaction: Evidence From a Priming Experiment

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Considerable research has shown that perceptions of inequity in relationships are associated with distress and relationship dissatisfaction, thus providing support for equity theory’s predictions. The evidence, however, is based primarily on correlational data, making it difficult to determine causality. The reverse causal direction could also explain the correlational findings—dissatisfaction could lead to perceptions of inequity.… Continue reading Inequity Leads to Distress and a Reduction in Satisfaction: Evidence From a Priming Experiment

Plastic surgery

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Plastic surgery: A surgical specialty that is dedicated to reconstruction of facial and body defects due to birth disorders, trauma, burns, and disease. Plastic surgery is also involved with the enhancement of the appearance of a person through cosmetic surgery. MedTerms (TM) is the Medical Dictionary of MedicineNet.com. We Bring Doctors’ Knowledge To You from… Continue reading Plastic surgery

External Validation of the Acoustic Voice Quality Index Version 03.01 With Extended Representativity

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Objectives: The Acoustic Voice Quality Index (AVQI) is an objective method to quantify the severity of overall voice quality in concatenated continuous speech and sustained phonation segments. Recently, AVQI was successfully modified to be more representative and ecologically valid because the internal consistency of AVQI was balanced out through equal proportion of the 2 speech types. The present investigation aims to explore its external validation in a large data set. Methods: An expert panel of 12 speech-language therapists rated the voice quality of 1058 concatenated voice... περισσότερα »

Dendritic cells generated from peripheral blood monocytes (Mo-DCs) and stimulated with laryngeal cancer cell lysates are not good enough in stimulating anti-tumor immunity

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 7 March 2016 *Source:*Oral Oncology Author(s): Eliza Trzaskowska-Komoń, Magdalena Wasiak, Jacek Roliński, Janusz Klatka from #ORL via xlomafota13 on Inoreader http://ift.tt/1R4tPNl via IFTTT

Hypertrophic neuropathy in Noonan syndrome with multiple lentigines

RASopathies comprise several genetic syndromes with mainly cardio–facial–cutaneous manifestations. We report a patient with Noonan syndrome with multiple lentigines (NSML) due to a *PTPN11* (p.Thr468Met) mutation associated with hypertrophic neuropathy of lumbar plexus in an adult woman, initially referred for neuropathic pain. Differential diagnosis of neurofibromatosis type 1 (NF1) and other RASopathies is difficult without molecular testing. © 2016 Wiley Periodicals, Inc. from Genetics via xlomafota13 on Inoreader http://ift.tt/1R2h3IK via IFTTT

Space maintenance in autogenous fresh demineralized tooth blocks with platelet-rich plasma for maxillary sinus bone formation: a prospective study

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
This prospective study evaluated the effectiveness of autogenous fresh demineralized tooth block (Auto-FDT block) with platelet-rich plasma (PRP) for maxillary sinus augmentation with simultaneous implant inst... from #Medicine via ola Kala on Inoreader http://ift.tt/1U0pNFP Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Recombination hotspots: models and tools for detection

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Publication date: Available online 7 March 2016 *Source:*DNA Repair Author(s): Prosenjit Paul, Debjyoti Nag, Supriyo Chakraborty Recombination hotspots are the regions within the genome where the rate, and the frequency of recombination are optimum with a size varying from 1–2kb. The recombination event is mediated by the double-stranded break formation, guided by the combined enzymatic action of DNA topoisomerase and Spo 11 endonuclease. These regions are distributed non-uniformly throughout the human genome and cause distortions in the genetic map. Numerous lines of evidence sugge...περισσότερα »

Caries Detection around Restorations Using ICDAS and Optical Devices

Abstract Purpose Secondary caries is the major reason for replacement of restorations in operative dentistry. New detection methods and technology have the potential to improve the accuracy for diagnosis of secondary carious lesions. This in vitro study evaluated the performance of the ICDAS (International Caries Detection and Assessment System) visual criteria and optical devices for detecting secondary caries around amalgam and composite resin restorations in permanent teeth. Materials and Methods A total of 180 extracted teeth with Class I amalgam (*N* = 90) and resin composi... περισσότερα »

Small cell mesothelioma: A rare entity and diagnostic pitfall mimicking small cell lung carcinoma on fine-needle aspiration

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 2 ώρες
Small cell mesothelioma (SCM) is an extremely rare variant of epithelioid mesothelioma that can be mistaken for other forms of small round blue cell tumors, particularly small cell lung carcinoma (SCLC). Here, we describe a fine-needle aspiration (FNA) from a pleural lesion in a 75-year-old man with a history of known asbestos exposure. The FNA revealed cohesive clusters of uniform small round blue cells with high nuclear-to-cytoplasmic ratio, finely powdery chromatin, small inconspicuous nucleoli, and scant amount of cytoplasm. Mitoses were infrequent and nuclear molding was abs...περισσότερα »

Physical Fitness During Adolescence and Long-Term Risk for Type 2 Diabetes Mellitus

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρες
from #Medicine via ola Kala on Inoreader http://ift.tt/1W4p3gH Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Adventitial Cystic Disease of the Common Femoral Vein—A Rare Mimic of Deep Venous Thrombosis: A Case Report

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρες
Clinicians usually can identify the cause of unilateral lower extremity swelling, but even experienced clinicians can be misled by rare causes of this condition. This case report describes unilateral lower extremity swelling that can be mistaken for deep venous thrombosis. from #Medicine via ola Kala on Inoreader http://ift.tt/21TQlNK Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Preparation of copper-containing bioactive glass/eggshell membrane nanocomposites for improving angiogenesis, antibacterial activity and wound healing


Publication date: Available online 7 March 2016 Source:Acta Biomaterialia Author(s): Jinyan Li, Dong Zhai, Fang Lv, Qingqing Yu, Hongshi Ma, Jinbo Yin, Zhengfang Yi, Mingyao Liu, Jiang Chang, Chengtie Wu Effectively stimulating angiogenesis and avoiding wound infection are great challenges in wound care management. Designing new healing dressings with requisite angiogenic capacity and antibacterial performance […]

Salt-Responsive Polyzwitterionic Materials for Surface Regeneration between Switchable Fouling and Antifouling Properties


Publication date: Available online 7 March 2016 Source:Acta Biomaterialia Author(s): Hong Chen, Jintao Yang, Shengwei Xiao, Rundong Hu, Sarang M. Bhaway, Bryan D. Vogt, Mingzhen Zhang, Qiang Chen, Jie Ma, Yung Chang, Lingyan Li, Jie Zheng Development of smart regenerative surface is a highly challenging but important task for many scientific and industrial applications. Specifically, […]

Complementary clinical effects of red complex bacteria on generalized periodontitis in a caucasian population


ConclusionsThe prevalence of red complex bacteria was similar between aggressive and chronic periodontitis but their count was higher in the former. In both diseases, T. forsythia was associated with greater severity and T. denticola with more severe bleeding. Tobacco smoking was not associated with the presence of red complex bacteria in either disease.This article is […]

Prognostic significance of CD44v6, p63, podoplanin and MMP‐9 in oral squamous cell carcinomas


ConclusionPodoplanin and MMP‐9 together could contribute to tumour progression and dissemination of OSCC. Their combined overexpression showed an adverse effect on survival, suggesting that they could be regarded as important prognostic biomarkers in OSCC. (Source: Oral Diseases) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TGsdd5 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 […]

Sentinel lymph node biopsy for head and neck mucosal cancers ‐ an update on the current evidence


This article is protected by copyright. All rights reserved. (Source: Oral Diseases) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YpHgH4 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Oral delivery of diabetes peptides – Comparing standard formulations incorporating functional excipients and nanotechnologies in the translational context


Publication date: Available online 8 March 2016 Source:Advanced Drug Delivery Reviews Author(s): Harivardhan Reddy Lakkireddy, Matthias Urmann, Melissa Besenius, Ulrich Werner, Torsten Haack, Priscilla Brun, Jean Alié, Brigitte Illel, Laurent Hortala, Rachel Vogel, Didier Bazile While some orally delivered diabetes peptides are moving to late development with standard formulations incorporating functional excipients, the demonstration of […]

Haemostatic property of cyanoacrylate in pedicled flaps


We present a technique that can, in principle, be applied to any pedicled flap that is routinely used for reconstructions of the forehead. In our experience, cyanoacrylate glue applied to the pedicle before the flap is inserted decreases postoperative bleeding and wound exudate. (Source: The British Journal of Oral and Maxillofacial Surgery) from #Medicine-SfakianakisAlexandros via […]

Letter in reply to Letter to the Editor concerning our paper entitled: Atrophy of anterior digastric muscle detected during ultrasound of the neck – a prospective clinical study


We thank Dr Zdilla for his interest in our study, and kind comments. (Source: The British Journal of Oral and Maxillofacial Surgery) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YpHgXK via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Case of infective endocarditis with initial presentation of visual disturbances


Publication date: Available online 7 March 2016 Source:The American Journal of Emergency Medicine Author(s): Fong-Pu Chang, Cheng-Yu Chien, Chung-Hsien Chaou, Ching-Hsing Lee from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UOQgWt via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

An unusual cause of acute chest pain: rupture of the noncoronary sinus of Valsalva into the right atrium


Publication date: Available online 8 March 2016 Source:The American Journal of Emergency Medicine Author(s): Giuseppe D. Sanna, Giuseppe Talanas, Cristiana Denurra, Paolo Ferrandu, Luca Bullitta, Pierfranco Terrosu Ruptured sinus of Valsalva aneurysm is a rare cardiac anomaly and it can be acquired or congenital. Untreated, there is a substantial risk of complications, expecially if rupture […]

Assessment of a polyelectrolyte multilayer film coating loaded with BMP-2 on titanium and PEEK implants in the rabbit femoral condyle

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 3 ώρες
Publication date: Available online 7 March 2016 *Source:*Acta Biomaterialia Author(s): R. Guillot, I. Pignot-Paintrand, J. Lavaud, A. Decambron, E. Bourgeois, V. Josserand, D. Logeart-Avramoglou, E. Viguier, C. Picart The aim of this study was to evaluate the osseointegration of titanium implants (Ti-6Al-4V, noted here TA6V) and poly(etheretherketone) PEEK implants induced by a BMP-2-delivering surface coating made of polyelectrolyte multilayer films. The in vitro bioactivity of the polyelectrolyte film-coated implants was assessed using the alkaline phosphatase assay. BMP-2-coated ... περισσότερα »

The efficacy of iodine-125 permanent brachytherapy versus intensity-modulated radiation for inoperable salivary … – BMC Blogs Network


The efficacy of iodine-125 permanent brachytherapy versus intensity-modulated radiation for inoperable salivary … BMC Blogs Network Primary malignant tumors of the major and minor salivary glands are relatively rare entities, accounting for only about 3–5 % of all head and neck malignancies. They also contain a diverse group of histologies, with disparate characteristics in terms […]

MLB memo: No dipping at Fenway, Dodger Stadium, SF – ESPN


ESPN MLB memo: No dipping at Fenway, Dodger Stadium, SF ESPN Toronto Blue Jays manager John Gibbons applauded the effort to cut down on chaw. He quit a couple years ago after Hall of Famer Tony Gwynn — a career-long dipper — died at 54 of salivary gland cancer. «I was a tobacco user for […]

Apoptosis inducing nanocomposites of Ag/HRG in A549 lung cancer


Khan M, Khan M, Al-Marri AH, Al-Warthan A, Alkhathlan HZ, Siddiqui MR, Nayak VL, Kamal A, Adil SF from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1LaW0HY via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Effects of CuO NPs on developing zebrafish


Sun Y, Zhang G, He Z, Wang Y, Cui J, Li Y from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TGiDHb via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Primary CNS lymphoma at first relapse/progression: characteristics, management, and outcome of 256 patients from the French LOC network


Background Treatment of relapsed/refractory (R/R) primary CNS lymphoma (PCNSL) is poorly defined, because randomized trials and large studies are lacking. The aim of this study was to analyze the characteristics, management, and outcome of R/R PCNSL patients after first-line therapy in a nationwide cohort. Methods We analyzed R/R PCNSL patients following first-line treatment who had […]

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου