OtoRhinoLaryngology & Medicine,New Articles,December 16th,2015,a

Peroral endoscopic myotomy for achalasia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Factors predicting the technical difficulty of peroral endoscopic myotomy for achalasia: Abstract BackgroundPeroral endoscopic myotomy (POEM) has been described as a novel treatment for esophageal achalasia. Owing to its technical difficulty, POEM is not widely performed. This study was aimed to prospectively assess the factor predicting technical difficulty of POEM in a single center with large volume cases. MethodsA total of 105 cases of achalasia treated by POEM from April 2011 to September 2014 were analyzed. Difficult cases of POEM were defined as procedure time ≥90 min a...περισσότερα »

Nissen fundoplication after endoscopic radiofrequency ablation of Barrett’s esophagus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Significance of Nissen fundoplication after endoscopic radiofrequency ablation of Barrett’s esophagus: Abstract ObjectiveHALO radiofrequency ablation (RFA) has been proven as safe and efficient in eradication of both non- and dysplastic Barrett’s esophagus (BE). Definitive post-RFA treatment is yet to be determined. MethodsRFA was performed in 56 patients with BE, 38 with intestinal metaplasia (IM) and 18 with low-grade dysplasia (LGD), and repeated in case of residual BE. Length of the BE was classified according to C&M criteria. Follow-up included regular upper GI endoscopie... περισσότερα »

Revisional paraesophageal hernia repair outcomes compare favorably to initial operations

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Revisional paraesophageal hernia repair outcomes compare favorably to initial operations: Abstract BackgroundRecurrent paraesophageal hernia (PEH) repair is performed for symptomatic recurrent hiatal hernia and/or reflux with little understanding as to outcomes related to perioperative and subjective patient variables. The aim of this study was to understand what differences exist between patients undergoing initial paraesophageal hernia (IPEH) repair and those undergoing redo paraesophageal hernia (RPEH) repair. MethodsA review of PEH repairs between 2009 and 2013 was performe... περισσότερα »

Preserving the pulmonary vagus nerve branches during thoracoscopic esophagectomy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Preserving the pulmonary vagus nerve branches during thoracoscopic esophagectomy: Abstract BackgroundPulmonary vagus branches are transected as part of a transthoracic esophagectomy and lymphadenectomy for cancer. This may contribute to the development of postoperative pulmonary complications. Studies in which sparing of the pulmonary vagus nerve branches during thoracoscopic esophagectomy is investigated are lacking. Therefore, this study aimed to determine the feasibility and pitfalls of sparing pulmonary vagus nerve branches during thoracoscopic esophagectomy. MethodsIn 10 ...περισσότερα »

Combined thoracoscopic-laparoscopic esophagectomy versus open esophagectomy: a meta-analysis of outcomes

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Combined thoracoscopic-laparoscopic esophagectomy versus open esophagectomy: a meta-analysis of outcomes: Abstract ObjectivesAt present there is controversy regarding the optimal surgical method for esophageal cancer. Specifically, whether combined thoracoscopic-laparoscopic esophagectomy is superior to open esophagectomy with respect to the surgical wound, perioperative morbidities and mortality, and the overall survival rate is of great concern. This article aimed to compare thoracoscopic-laparoscopic esophagectomy versus open esophagectomy on the perioperative morbidities and l... περισσότερα »

Magnetic sphincter augmentation for treating gastroesophageal reflux disease

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Revaluation of the efficacy of magnetic sphincter augmentation for treating gastroesophageal reflux disease: Abstract BackgroundGastroesophageal reflux disease (GERD) is a prevalent disease which severely impacts the quality of life of the patients. The surgical options are limited to such patients who are not satisfied with medical therapies. Magnetic sphincter augmentation (MSA) is a new antireflux surgical technique for treating GERD, which could physiologically reinforce the lower esophageal sphincter by magnetic force. Many clinical and animal studies have focused on this new... περισσότερα »

Endoscopic via unilateral axillobreast approach versus open conventional total thyroidectomy in patients with papillary thyroid carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Prospective comparative study of endoscopic via unilateral axillobreast approach versus open conventional total thyroidectomy in patients with papillary thyroid carcinoma: Abstract BackgroundTotal thyroidectomy can be accomplished in one of two ways. The first is an open conventional approach, and the other is an endoscopic unilateral axillobreast approach (UABA). However, the two have not been thoroughly compared. In the study described herein, we compare the technical feasibility, safety, and surgical completeness of open versus endoscopic total thyroidectomy procedures. Met...περισσότερα »

EBV Status and Thiopurine Use in Pediatric IBD.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

EBV Status and Thiopurine Use in Pediatric IBD.: Objectives: Epstein Barr virus (EBV) is a human herpes virus that infects 90% of the world's population and has been linked to the development of lymphoproliferative disorders (LPDs) and immunosuppression. Primary EBV infection in IBD patients on thiopurines is a risk factor for LPD, including lymphoma. We aimed to describe EBV status in a pediatric IBD population with an emphasis on those initiating thiopurines. Methods: Electronic medical records and EBV serologies were reviewed and categorized into asymptomatic screening vs. suspici...περισσότερα »

Functional Nausea in Children.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Functional Nausea in Children.: Chronic nausea is a highly prevalent, bothersome and difficult-to-treat symptom among adolescents. When chronic nausea presents as the predominant symptom and is not associated with any underlying disease, it may be considered a functional gastrointestinal disorder and named "functional nausea". The clinical features of functional nausea and its association with co-morbid conditions provide clues to the underlying pathophysiological mechanisms. These may include gastrointestinal motor and sensory disturbances, autonomic imbalance, altered CNS pathways... περισσότερα »

Tumor/normal esophagus ratio in 18 F-fluorodeoxyglucose positron emission tomography/computed tomography for response and prognosis stratification after neoadjuvant chemotherapy for esophageal squamous cell carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Tumor/normal esophagus ratio in 18 F-fluorodeoxyglucose positron emission tomography/computed tomography for response and prognosis stratification after neoadjuvant chemotherapy for esophageal squamous cell carcinoma: Abstract BackgroundPositron emission tomography (PET) response criteria in solid tumors were recently proposed as a standardized method for the metabolic and quantitative assessment of response to chemotherapy. However, use of these criteria is limited in many institutions because of the need for exclusive software. This study was designed to clarify whether tumor to ... περισσότερα »

Outcome of TORS to tongue base and epiglottis in patients with OSA intolerant of conventional treatment

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Outcome of TORS to tongue base and epiglottis in patients with OSA intolerant of conventional treatment: Abstract PurposeTransoral robotic surgery (TORS) of the tongue base with or without epiglottoplasty represents a novel treatment for obstructive sleep apnea (OSA). The objective was to evaluate the clinical efficacy of TORS of the tongue base with or without epiglottoplasty in patients who had not tolerated or complied with conventional treatment (continuous positive airway pressure or oral appliance). MethodsFour-year prospective case series. The primary outcome measure was... περισσότερα »

The efficacy of the OSA-18 as a waiting list triage tool for OSA in children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

The efficacy of the OSA-18 as a waiting list triage tool for OSA in children: Abstract PurposeSleep disordered breathing (SDB) is common in children, resulting in extensive waiting lists for specialist clinics. There is an urgent need for a valid method of triaging patients and the OSA-18, a disease-specific tool, is an attractive candidate for this role. We aimed to examine the OSA-18 as a measurement tool in detail and to determine whether the score or aspects of it could be used as a screening tool for SDB in children. MethodsRetrospective analysis of 582 children (6 months t... περισσότερα »

Taste Sensitivity, Food Liking, and Food Neophobia

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 8 δευτερόλεπτα

Determinants of Obesity in Italian Adults: The Role of Taste Sensitivity, Food Liking, and Food Neophobia: Recent evidence has suggested that factors related to sensory perception may explain excess weight. The objective of this study was to consider multiple aspects while investigating the phenomenon of obesity. One goal was to compare taste acuity (taste threshold and density of fungiform papillae) in both normal weight and obese subjects. Thresholds for 4 basic tastes and the fat stimulus were investigated. A second research goal was to study the relationship between food neopho... περισσότερα »

Pituitary Adenoma Leads to Adenoid Cystic Carcinoma in the Oral Cavity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Pituitary Adenoma Leads to Adenoid Cystic Carcinoma in the Oral Cavity: An Intriguing Case: AbstractAdenoid cystic carcinoma is a tumor of the exocrine glands originating primarily from the minor salivary glands. Though rare but there has been incidences of its spread into intracranial sites via different routes. We report of an intriguing case of remote metastasis of intracranial tumor in the pituitary diagnosed as pituitary adenoma which spread to the oral cavity as adenoid cystic carcinoma. To our knowledge, this is the first reported case of seeding of cells from intra cranial ... περισσότερα »

Submental-Cervical Angle: Perceived Attractiveness and Threshold Values of Desire for Surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Submental-Cervical Angle: Perceived Attractiveness and Threshold Values of Desire for Surgery: Abstract AimThe submental-cervical angle may alter as a result of mandibular orthognathic surgery and/or the ageing process and is therefore an important facial aesthetic parameter for comparative diagnosis and treatment planning. The purpose of this study was to undertake a quantitative evaluation of the influence of the submental-cervical angle on perceived attractiveness and threshold values of desire for surgery. Study DesignThe submental-cervical angle of an idealized profile sil... περισσότερα »

A Comparative Study of Trigger Point Therapy with Local Anaesthetic (0.5 % Bupivacaine) Versus Combined Trigger Point Injection Therapy and Levosulpiride in the Management of Myofascial Pain Syndrome in the Orofacial Region

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

A Comparative Study of Trigger Point Therapy with Local Anaesthetic (0.5 % Bupivacaine) Versus Combined Trigger Point Injection Therapy and Levosulpiride in the Management of Myofascial Pain Syndrome in the Orofacial Region: Abstract AimTo compare the efficacy of combined local anesthetic injection with 0.5 % bupivacaine and levosulpiride versus local anesthetic injection alone on outcome measures including levels of pain intensity and depression in the management of myofascial pain syndrome in orofacial region. Patients and MethodsThis was a prospective, randomized, controlled...περισσότερα »

Effect of surgical mandibular advancement on pharyngeal airway dimensions: a three-dimensional computed tomography study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Effect of surgical mandibular advancement on pharyngeal airway dimensions: a three-dimensional computed tomography study: The aim of this study was to quantify the changes in pharyngeal airway space (PAS) in patients with a skeletal class II malocclusion managed by bilateral sagittal split ramus osteotomy for mandibular advancement, using three-dimensional (3D) registration. The sample comprised 16 patients (mean age 21.69±2.80 years). Preoperative (T0) and postoperative (T1) computed tomography scans were recorded. Linear, cross-sectional area (CSA), and volumetric parameters of th...περισσότερα »

Age-related and sex-related changes in the normal soft tissue profile

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Age-related and sex-related changes in the normal soft tissue profile of native Northern Sudanese subjects: a cross-sectional study: Information about age-related and sex-related normative measurements of the nasolabial region in native Northern Sudanese subjects is scanty. We have therefore used a hand-held laser scanner to measure nasolabial angles and distances, and collected the 3-dimensional coordinates of seven landmarks on the facial soft tissues from 654 healthy native Northern Sudanese subjects (327 male and 327 female, aged 4-30 years). From these we calculated five angles ...περισσότερα »

mTOR pathway protein immunoexpression as a prognostic factor for survival in head and neck cancer patients: a systematic review and meta-analysis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

mTOR pathway protein immunoexpression as a prognostic factor for survival in head and neck cancer patients: a systematic review and meta-analysis: Background Several mTOR pathway proteins are involved in the regulation of cellular anabolism, growth, proliferation, and survival. Activated proteins in the mTOR pathway are deregulated in multiple types of cancers and could influence prognosis. However, it is unclear whether deregulation of mTOR pathway proteins serves a prognostic role in patients with head and neck cancer (HNC). Furthermore, proteins in the mTOR pathway may be importa... περισσότερα »

CD1a+ and CD83+ Langerhans cells are reduced in lower lip squamous cell carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

CD1a+ and CD83+ Langerhans cells are reduced in lower lip squamous cell carcinoma: Background Actinic cheilitis (AC) is a potentially malignant lesion diagnosed in the lip of patients chronically exposed to the sun that may give rise to a fully invasive lower lip squamous cell carcinoma (LLSCC). It is known that ultraviolet radiation causes dendritic cells (DCs) depletion in the epidermis, but the role of this cellular population in lip cancer progression remains uncertain. Therefore, this study investigated the distribution of DCs in normal, dysplastic and neoplastic tissues of th... περισσότερα »

A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα

Publication date: Available online 15 December 2015 Source:Oral Oncology Author(s): Daniel W. Bowles, Stephen B. Keysar, Justin R. Eagles, Guoliang Wang, Magdalena J. Glogowska, Jessica D. McDermott, Phuong N. Le, Dexiang Gao, Charles E. Ray, Paul J. Rochon, Dennis R. Roop, Aik-Choon Tan, Hilary S. Serracino, Antonio Jimeno BackgroundThis phase 1, dose-finding study determined the […]

Propionibacterium acnes as a cause of lung abscess in a cardiac transplant recipient

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα

A 29-year-old man was admitted with fevers, cough, left-sided chest pain and lethargy for 1 week. He had a cardiac transplant 10 years prior and was on immunosuppressive drugs. He was found to have a pulmonary lesion and went on to develop a lung abscess. Propionibacterium acnes was identified on matrix-assisted laser desorption ionisation mass […]

An assessment of the potential health impacts of food reformulation

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα

An assessment of the potential health impacts of food reformulation European Journal of Clinical Nutrition advance online publication, December 16 2015. doi:10.1038/ejcn.2015.201 Authors: P Leroy, V Réquillart, L-G Soler & G Enderli from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NT15nd via IFTTT

Fluid consumption, total water intake and first morning urine osmolality in Spanish adolescents from Zaragoza: data from the HELENA study

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα

Fluid consumption, total water intake and first morning urine osmolality in Spanish adolescents from Zaragoza: data from the HELENA study European Journal of Clinical Nutrition advance online publication, December 16 2015. doi:10.1038/ejcn.2015.203 Authors: I Iglesia, A M Santaliestra-Pasías, S Bel-Serrat, T Sadalla-Collese, M L Miguel-Berges & L A Moreno from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader […]

Sarcopenia and length of hospital stay

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα

Sarcopenia and length of hospital stay European Journal of Clinical Nutrition advance online publication, December 16 2015. doi:10.1038/ejcn.2015.207 Authors: A S Sousa, R S Guerra, I Fonseca, F Pichel & T F Amaral from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NT16aD via IFTTT

Dietary under-reporting: what foods and which meals are typically under-reported?

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα

Dietary under-reporting: what foods and which meals are typically under-reported? European Journal of Clinical Nutrition advance online publication, December 16 2015. doi:10.1038/ejcn.2015.204 Authors: L Gemming & C Ni Mhurchu from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NwY1cI via IFTTT

Stents in patients with esophageal cancer before chemoradiotherapy: high risk of complications and no impact on the nutritional status

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα

Stents in patients with esophageal cancer before chemoradiotherapy: high risk of complications and no impact on the nutritional status European Journal of Clinical Nutrition advance online publication, December 16 2015. doi:10.1038/ejcn.2015.206 Authors: S Mão-de-Ferro, M Serrano, S Ferreira, I Rosa, P Lage, D P Alexandre, J Freire, L Mirones, R Casaca, A Bettencourt & A […]

The effect of dietary counselling on food intakes in pregnant women at risk for gestational diabetes: a secondary analysis of a randomised controlled trial RADIEL

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα

The effect of dietary counselling on food intakes in pregnant women at risk for gestational diabetes: a secondary analysis of a randomised controlled trial RADIEL European Journal of Clinical Nutrition advance online publication, December 16 2015. doi:10.1038/ejcn.2015.205 Authors: A Valkama, S Koivusalo, J Lindström, J Meinilä, H Kautiainen, B Stach-Lempinen, K Rönö, M Klemetti, M […]

Diagnostic performance of body mass index to identify adiposity in women

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα

Diagnostic performance of body mass index to identify adiposity in women European Journal of Clinical Nutrition advance online publication, December 16 2015. doi:10.1038/ejcn.2015.211 Authors: A Gába & M Přidalová from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NwXZS1 via IFTTT

Factors Associated With Patient-perceived Hoarseness in Spasmodic Dysphonia Patients

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα

Publication date: Available online 15 December 2015 Source:Journal of Voice Author(s): Amanda Hu, Al Hillel, Tanya Meyer Objectives/HypothesisThe American Academy of Otolaryngology—Head and Neck Surgery Clinical Practice Guidelines on Hoarseness distinguishes between hoarseness, which is a symptom perceived by the patient, and dysphonia, which is a diagnosis made by the clinician. Our objective was to […]

Early arising sarcoma after adjuvant radiotherapy for oral squamous cell carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

Early arising sarcoma after adjuvant radiotherapy for oral squamous cell carcinoma via Oral and Maxillofacial Surgery *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Giuseppina Marchitto, Valerio Marci, Mattia Berrone, Monica Pentenero Radiation-induced sarcoma of the head and neck (RISHN) is a rare and long-term complication of radiation therapy (RT). This paper describes a case of RISHN characterized by early and insidious onset. An 80-year-old man was surgically treated for advanced oral squamous cell carcinoma of the left retromolar trigone (pT4aN0). Sixteen months ...περισσότερα »

DNA methylation markers for oral pre-cancer progression

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

DNA methylation markers for oral pre-cancer progression: A critical review: Oral cancer is a major public health problem in much of Asia, as well as certain regions of Eastern and Western Europe, Latin America, Caribbean countries and Melanesia [1–3]. Although high incidence zones in Asia (India, Sri Lanka, Pakistan, Bangladesh and China–Taiwan) contribute to over one third (37.5%) of the total global burden [1], recent trends suggest increasing incidence in the US and in parts of Europe including the United Kingdom [4,5]. Over a million new cases are reported every year from more d... περισσότερα »

De-epithelialised patch: a simple method to monitor free flaps intraorally

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

De-epithelialised patch: a simple method to monitor free flaps intraorally: Successful reconstruction of free flaps is dependent on the patency of the microvascular anastomoses.1,2 The best opportunity to salvage a flap is by early recognition of compromised perfusion and emergency revascularisation.3 There are many ways of monitoring flaps, from simple bedside checks (colour, refill, temperature), to more elaborate mechanisms (cutaneous Doppler monitoring, surface temperature probes, spectrophotometry, laser Doppler systems, implantable perianastomotic Dopplers, contrast enhanced D... περισσότερα »

B7-H3 overexpression in oral cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

B7-H3 overexpression in oral cancer: Abstract In a recent study published in *Proceedings of the National Academy of Sciences of the United States of America*, Chen and collaborators (2015), aiming to discover predictive markers with impact on treatment and survival of patients with oral squamous cell carcinoma (OSCC), described an important role of the transmembrane receptor B7 homolog 3 (B7-H3), also known as CD276 and B7RP-2, in OSCCs. Besides the overexpression of this protein, the results highlight differences in the N-glycan structure of this glycoprotein between normal and t...περισσότερα »

Survivin, cyclin d1 and p21hras in keratocystic odontogenic tumors before and after decompression

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα

Survivin, cyclin d1 and p21hras in keratocystic odontogenic tumors before and after decompression: Abstract Objectives The aim of this study was to investigate survivin, cyclin D1, and p21hras expression in keratocystic odontogenic tumors before and after decompression, as well as in pericoronal follicles. A potential correlation between the expression levels of these proteins was also investigated. Materials and methods We analyzed eighteen keratocystic tumors treated by decompression and subsequent enucleation along with seven pericoronal follicles using immunohistochemistry. Resu...περισσότερα »

Mouth cancer in inflammatory bowel diseases

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα

Mouth cancer in inflammatory bowel diseases: Abstract Mouth cancer is a major health problem. Multiple risk factors for developing mouth cancer have been studied and include history of tobacco and alcohol abuse, age over 40, exposure to ultraviolet radiation, human papilloma virus infection (HPV), nutritional deficiencies, chronic irritation and existence or oral potentially malignant lesions such as leukoplakia and lichen planus. An important risk factor for mouth cancer is chronic immunosuppression and has been extensively reported after solid-organ transplantation as well as HIV... περισσότερα »

‘Stylo-mandibular complex’ fracture

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα

from a maxillofacial surgeon's perspective – review of the literature and proposal of a management algorithm via Oral and Maxillofacial Surgery Publication date: Available online 15 December 2015 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): G. Gayathri, P. Elavenil, B. Sasikala, M. Pathumai, V.B. Krishnakumar Raja The incidence of fractures of styloid process, either in isolation or association with mandibular fractures, is rare, and frequently overlooked. When present, they pose clinical dilemma in diagnosis and management. Proper management of styloid ... περισσότερα »

Virtual occlusal definition.Computer-assisted surgical simulation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα

for orthognathic surgery via Oral and Maxillofacial Surgery Publication date: Available online 14 December 2015 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): X.J. Liu, Q.Q. Li, Z. Zhang, T.T. Li, Z. Xie, Y. Zhang Computer-assisted surgical simulation is being used increasingly in orthognathic surgery. However, occlusal definition is still undertaken using model surgery with subsequent digitization via surface scanning or cone beam computed tomography. A software tool has been developed and a workflow set up in order to achieve a virtual occlusal definitio...περισσότερα »

The Speech Handicap Index in patients with oral cavity cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα

Validity and reliability of the Korean version of via Oral and Maxillofacial Surgery Publication date: Available online 15 December 2015 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): S.S. Park, S.H. Choi, J.A. Hong, Y.H. Hong, N.G. Jeong, S.Y. Lee, M.-W. Sung, J.H. Hah The aims of this study were to evaluate the cross-cultural adaptation of the Speech Handicap Index (SHI) for Korean subjects and to determine its reliability and utility in patients with oral cavity cancer. The Korean version of the SHI was administered to 50 healthy subjects and 56 patient... περισσότερα »

Anteromedial fracture dislocation of the mandibular condyle

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα

Superolateral Dislocation of Intact Mandibular Condyle: A Case Report and Review of Literature: AbstractAnteromedial fracture dislocation of the mandibular condyle is common but a superolateral dislocation of an intact condyle is quite rare. This type of dislocation is often misdiagnosed or completely overlooked and hence inadequately addressed. We report a case of a 41-year-old male patient who experienced superolateral dislocation of the intact condyle with symphysis fracture and panfacial fracture following a road-traffic accident, and review of literature of superolateral dislo... περισσότερα »

Dermoid Cyst of the Lateral Neck Included Within the Submandibular Gland.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα

Dermoid Cyst of the Lateral Neck Included Within the Submandibular Gland.: Dermoid cysts are benign lesions of congenital origin, and those in the head and neck region are usually present as a midline neck mass. They rarely appear in the lateral neck. This article describes the clinical presentation and histopathologic features of an extremely rare case of lateral dermoid cyst included within the submandibular gland in a 58-year-old man. The etiology of the cyst is also discussed. (C) 2015 by Mutaz B. Habal, MD.

Afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV-negative or high-risk HPV-positive locally advanced stage III/IVa/IVb head and neck squamous cell carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα

A phase I study afatinib/carboplatin/paclitaxel induction chemotherapy followed by standard chemoradiation in HPV-negative or high-risk HPV-positive locally advanced stage III/IVa/IVb head and neck squamous cell carcinoma: Head and neck squamous cell carcinoma (HNSCC) causes a significant morbidity worldwide with the incidence of approximately 550,000 cases per year [1]. The most common risk factors are tobacco use and human papillomavirus (HPV) infection [2,3]. At diagnosis, a majority of patients present with locally advanced disease, but patients with HPV-positive HNSCC have a mo...περισσότερα »

Immunoexpression of growth factors and receptors in polymorphous low-grade adenocarcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα

Immunoexpression of growth factors and receptors in polymorphous low-grade adenocarcinoma: Background Polymorphous low-grade adenocarcinoma (PLGA) is a rare malignant tumor that usually arises in the minor salivary glands. Growth factors are cell-secreted peptides that regulate biological processes such as growth, proliferation, and differentiation. In salivary gland tumors, immunoexpression of growth factors and their receptors is associated with cell proliferation, malignant transformation, and tumor invasion. This study analyzed the expression of growth factors and receptors in ... περισσότερα »

IL-1β mediating high mobility group box protein-1 expression in condylar chondrocyte during temporomandibular joint inflammation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα

IL-1β mediating high mobility group box protein-1 expression in condylar chondrocyte during temporomandibular joint inflammation: Background Temporomandibular joint (TMJ) osteoarthritis(OA)characterized with cartilage degen-eration is associated with inflammation. High mobility group box chromosomal protein-1(HMGB-1)is a potent mediator of inflammation and the trigger of OA. The expression of HMGB-1 in TMJ OA was uncovered, but the role of HMGB-1 in TMJ cartilage degeneration is not fully understood. In this study, the regulation of HMGB-1 in TMJ condylar cartilage was revealed. Me...περισσότερα »

Effect of postoperative use of diclofenac on pharyngocutaneous fistula development after primary total laryngopharyngectomy: Results of a single-center retrospective study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα

Effect of postoperative use of diclofenac on pharyngocutaneous fistula development after primary total laryngopharyngectomy: Results of a single-center retrospective study: Abstract Background Primary total laryngopharyngectomy is the treatment of choice in many cases of locally advanced hypopharyngeal and laryngeal cancer. Development of pharyngocutaneous fistulae is the most common postoperative complication. A recent Danish study showed significantly increased rates of anastomosal leakage after colorectal resection in patients receiving diclofenac treatment. Methods We retrospec... περισσότερα »

Effects of Pregnancy on Papillary Microcarcinomas of the Thyroid

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Effects of Pregnancy on Papillary Microcarcinomas of the Thyroid Re-Evaluated in the Entire Patient Series at Kuma Hospital: Thyroid , Vol. 0, No. 0. Author information Yasuhiro Ito, Akira Miyauchi, Takumi Kudo, Hisashi Ota, Kana Yoshioka, Hitomi Oda, Hisanori Sasai,Ayako Nakayama, Tomonori Yabuta, Hiroo Masuoka, Mitsuhiro Fukushima, Takuya Higashiyama,Minoru Kihara, Kaoru Kobayashi, and Akihiro Miya © Ito *et al*. 2015; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://cre... περισσότερα »

Comparison of vocal outcome following two different procedures for immediate RLN reconstruction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Comparison of vocal outcome following two different procedures for immediate RLN reconstruction: AbstractThe objective of this study was to compare time-dependent improvements in phonatory function and stroboscopic findings following two different procedures for immediate reconstruction of the recurrent laryngeal nerve (RLN) during neck tumor extirpation. Seventeen patients with neck tumors, consisting of advanced thyroid cancer (*n* = 15), metastatic neck lymph nodes from other malignant lesions (*n* = 2), underwent resection of the primary lesion and involved RLN. Immediate RLN ...περισσότερα »

Endoscopic view of an osteoma of the maxillary sinus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Endoscopic view of an osteoma of the maxillary sinus: A 70-year-old woman was referred to Otolaryngology after her dentist discovered an incidental finding on her panoramic x-ray. She had a lesion of the left maxillary sinus. The patient's presenting dental problem was that her crowns were falling off her left upper dental arch. She had a history of recurrent left sinus infections treated by her family doctor 25 years previously but had no recent sinus symptoms.

Reconstruction after resection of a lower lip squamous cell carcinoma with a submental island flap

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Reconstruction after resection of a lower lip squamous cell carcinoma with a submental island flap: IntroductionThe lips are important aesthetically because of their prominent location on the face and functionally because of the essential mechanism of the sphincter in assisting mastication, swallowing, phonation, and expressing emotions.1,2 Therefore, lip defects that are caused by wide resection secondary to trauma or a tumor should be appropriately reconstructed to achieve satisfactory results in terms of aesthetics and functional recovery.

The relationship between hearing impairment and cognitive function

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

The relationship between hearing impairment and cognitive function: A meta-analysis in adults: Abstract Background Hearing loss affects over 1.23 billion people globally. It has been proposed that hearing impairment negatively impacts on cognition. Some studies have demonstrated a faster rate of decline in cognition, and increased risk of incident all-cause dementia. This finding is not ubiquitous. This study used meta-analysis to examine the evidence-base regarding the relationship between hearing and cognition. Objective and type of review Meta-analyses examined evidence for and a...περισσότερα »

Recurrent Juvenile Nasopharyngeal Angiofibroma (JNA) After Radiation Therapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Clinical Characteristics of Recurrent Juvenile Nasopharyngeal Angiofibroma (JNA) After Radiation Therapy: AbstractJuvenile nasopharyngeal angiofibroma (JNA) is a benign vascular tumor occurring in young males. Treatment of JNA is a complex procedure, especially in advanced cases with a high risk of major complications. We report the clinical, radiological and histological specialties of a rare case of recurrent JNA 3 years after radiation therapy in an 18-year-old boy. The patient underwent endoscopy assisted partial midfacial degloving approach. This treatment has been shown to be... περισσότερα »

Otolaryngologic Manifestations of Rheumatic Diseases

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Otolaryngologic Manifestations of Various Rheumatic Diseases: Awareness and Practice Among Otolaryngologists: AbstractWegener’s granulomatosis, Sarcoidosis, Sjögren’s Syndrome, Behçet disease, Systemic lupus erythematosus, relapsing polychondritis, Churg–Strauss syndrome and Cogan syndromes are rheumatic diseases commonly encountered by otolaryngologists. The present study was designed to assess the understanding and practice about various ENT problems of rheumatic diseases amongst otolaryngologists. A group of 29 otolaryngologists was asked to fill questionnaire which was based on... περισσότερα »

Electronystagmography a Very Useful Diagnostic Tool in Cases of Vertigo

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Electronystagmography a Very Useful Diagnostic Tool in Cases of Vertigo: AbstractA significant number of patients seen in otorhinolaryngology have symptoms of vestibular dysfunction. Examination of vestibulo-ocular reflex has been and still is the principal method of evaluating vestibular functions. Electronystagmography (ENG) has been the gold standard to test the vestibular functions. The present study aims to evaluate the utility of ENG in diagnosing the etiology of vertigo. Total of 50 patients of either sex presenting with vertigo underwent ENG after a detailed history accordi... περισσότερα »

Comparative Study of Improvement of Nasal Symptoms Following Septoplasty with Partial Inferior Turbinectomy Versus Septoplasty Alone in Adults by NOSE Scale: A Prospective Study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Comparative Study of Improvement of Nasal Symptoms Following Septoplasty with Partial Inferior Turbinectomy Versus Septoplasty Alone in Adults by NOSE Scale: A Prospective Study: AbstractTo compare the symptomatic improvement of nasal symptoms following septoplasty with partial inferior turbinectomy (groups A) versus septoplasty alone (groups B) and to assess the improvement of nasal symptoms in both surgical groups before and after surgery by NOSE scale. This Tertiary Hospital based study was carried out between August 2012 and April 2014. 60 cases with septal deviation and contra... περισσότερα »

Middle and Lower Face Soft Tissue Reconstruction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Middle and Lower Face Soft Tissue Reconstruction: A 10-Year Retrospective Study: AbstractRetrospectively analyze the reconstruction methods and surgical outcomes of patients with middle and lower face soft tissue defects treated at our hospital over the past 10 years. *200* patients with middle and lower face soft tissue defects were surgically reconstructed at our hospital. Medical charts were retrospectively reviewed and analyzed to abstract the pertinent information. The lesion was mainly at the eyelid, lips, chin and nasal-cheek region. There were 41 (63.08 %) men and 24 (36.9... περισσότερα »

Role of 18-Fludeoxyglucose positron emission tomography-computed tomography and subsequent panendoscopy in head and neck squamous cell carcinoma of unknown primary

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Role of 18-Fludeoxyglucose positron emission tomography-computed tomography and subsequent panendoscopy in head and neck squamous cell carcinoma of unknown primary: Objectives/Hypothesis Head and neck squamous cell carcinomas of unknown primary (HNSCCUP) accounts for up to 10% of presenting head and neck squamous cell carcinomas. Identification of the primary site allows for directed therapy. Where initial investigations have failed to locate the primary site, 18-fludeoxyglucose positron emission tomography-computed tomography (PET/CT) has emerged as a useful tool with improved sen... περισσότερα »

Cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic HNSCC

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma via ScienceDirect Publication: Oral Oncology Publication date: Available online 15 December 2015 *Source:*Oral Oncology Author(s): Daniel W. Bowles, Stephen B. Keysar, Justin R. Eagles, Guoliang Wang, Magdalena J. Glogowska, Jessica D. McDermott, Phuong N. Le, Dexiang Gao, Charles E. Ray, Paul J. Rochon, Dennis R. Roop, Aik-Choon Tan, Hilary S. Serracino, Antonio Jimeno BackgroundThis phase 1, dose-finding study determined the safety, maximum tolerated dose (MTD)/... περισσότερα »

PET (Positron emission tomography) radiotracer called FACBC in the assessment of head and neck cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα

FACBC for Head and Neck Cancers: *Condition*: Cancers of the Head and Neck *Intervention*: Drug: FACBC *Sponsor*: Emory University The purpose of this study is to assess a relatively new PET (Positron emission tomography) radiotracer called FACBC in the assessment of head and neck cancer. FDG (Flourine Deoxyglucose) is currently used for PET imaging, but has limitations in head and neck cancer. These limitations include problems with specificity, high background uptake from normal structures, difficulty delineating intracranial invasion, and the need to wait several weeks a...περισσότερα »

Postoperative Pain Management After Minimally Invasive Esophagectomy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα

Postoperative Pain Management After Minimally Invasive Esophagectomy: *Condition*: Esophageal Cancer *Interventions*: Other: continuous epidural infusion; Other: combined paravertebral infusion and single shot of TAP block *Sponsor*: Sun Yat-sen University ArmsAssigned InterventionsActive Comparator: Epidural Epidural catheters will be applied at the T6-8 level prior to the induction. 6 ml of 2% xylocaine with 1 in 200,000 epinephrine administered before surgery. During the surgery, 2% xylocaine with 1 in 200,000 epinephrine infusion will be administered at a rate of 2-10 ml... περισσότερα »

Gemcitabine - Oxaliplatin for Advanced Refractory Thyroid Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα

Gemcitabine - Oxaliplatin for Advanced Refractory Thyroid Cancer Patients: a Phase II Study: *Condition*: Thyroid Cancer *Intervention*: Drug: gemcitabine -oxaliplatine combination *Sponsor*: Assistance Publique - Hôpitaux de Paris Radioiodine refractory differentiated thyroid cancer is a rare tumor and therapeutic options are limited in this setting. Molecular targeted therapies have recently been developed for progressive disease and demonstrated clinical activity, especially with anti-angiogenic agents. For patients with contra-indication to these agents or in case of pro... περισσότερα »

Hand Dominance and Blood Group: Association in Epistaxis

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα

Abstract The present work was undertaken to study the association of epistaxis with hand dominance and blood group. The present cross sectional study was conducted among 360 cases of epistaxis who reported to the E.N.T outpatient department of tertiary care centre in central India during the period of July 2014 to July 2015. Examination was […]

A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα

Publication date: Available online 15 December 2015 Source:Oral Oncology Author(s): Daniel W. Bowles, Stephen B. Keysar, Justin R. Eagles, Guoliang Wang, Magdalena J. Glogowska, Jessica D. McDermott, Phuong N. Le, Dexiang Gao, Charles E. Ray, Paul J. Rochon, Dennis R. Roop, Aik-Choon Tan, Hilary S. Serracino, Antonio Jimeno BackgroundThis phase 1, dose-finding study determined the […]

Factors Associated With Patient-perceived Hoarseness in Spasmodic Dysphonia Patients

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα

The American Academy of Otolaryngology—Head and Neck Surgery Clinical Practice Guidelines on Hoarseness distinguishes between hoarseness, which is a symptom perceived by the patient, and dysphonia, which is a diagnosis made by the clinician. Our objective was to determine factors that are associated with patient-perceived hoarseness in spasmodic dysphonia (SD) patients. from #ORL-AlexandrosSfakianakis via ola […]

Observational cohort study of the natural history of Niemann-Pick disease type C in the UK: a 5-year update from the UK clinical database

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα

Background: Niemann-Pick disease type C (NP-C) is a rare neurovisceral lipid storage disorder characterised by progressive, disabling neurological symptoms and premature death in most patients. During the last decade, national cohort studies have accrued a great deal of data on the symptomatology and natural history of NP-C. Methods: In an observational cohort study, we present […]

Prospective study of predictors and consequences of insomnia: personality, lifestyle, mental health and work-related stressors

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα

Publication date: Available online 15 December 2015 Source:Sleep Medicine Author(s): Øystein Vedaa, Elfrid Krossbakken, Ingse Dagny Grimsrud, Bjørn Bjorvatn, Børge Sivertsen, Nils Magerøy, Ståle Einarsen, Ståle Pallesen ObjectiveTo prospectively investigate the reciprocal relationships between personality traits, lifestyle factors, mental health, sleepiness, and work-related stressors against insomnia.MethodsA total of 799 Norwegian shift-working nurses (mean age 33.2 […]

Factors Associated With Patient-perceived Hoarseness in Spasmodic Dysphonia Patients

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα

Publication date: Available online 15 December 2015 Source:Journal of Voice Author(s): Amanda Hu, Al Hillel, Tanya Meyer Objectives/HypothesisThe American Academy of Otolaryngology—Head and Neck Surgery Clinical Practice Guidelines on Hoarseness distinguishes between hoarseness, which is a symptom perceived by the patient, and dysphonia, which is a diagnosis made by the clinician. Our objective was to […]

Up it goes – The Courier

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα

The Courier Up it goes The Courier #CPSCCO As generational cancer survivors, we can only imagine how proud they are of their son: Boyd Davis III Read his story of overcoming adversity posted by The University of Findlay: https://goo.gl/FM4ha9 #cancersurvivor #familyprideCancer Patient … and more » from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QpDOeY via IFTTT

Nonsteroidal antiinflammatory drug induced acute granulomatous interstitial nephritis

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα

Background: Acute interstitial nephritis is a common cause of acute kidney injury (AKI). The granulomatous inflammation is rarely but often manifests as a form of a granulomatous interstitial nephritis (GIN) in the kidney. Acute granulomatous interstitial nephritis is mainly associated with drugs, infection and autoimmune diseases.Case presentationA 44-year-old-male visited our out-patient department with symptoms of […]

Clozapine induced pancytopenia leading to severe sepsis: an unusual early complication

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα

ABSTRACT Background: Clozapine is a second generation antipsychotic used to treat resistant schizophrenia and other psychotic illnesses. Leucopenia or agranulocytosis is a rare side effect of this drug. Pancytopenia is an extremely rare side effect of clozapine and literature review showed only one such case in where the pancytopenia developed several months after starting clozapine […]

A case report of lameness in two dairy goat herds; a suspected combination of nutritional factors concurrent with treponeme infection

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα

Background: Two dairy goat farms with high level of lameness in lactating animals were presented for further investigation. Farm 1 and Farm 2 presented with 37 and 67 % morbidity, respectively. Both farms had an all year round indoor system, feeding ad libitum concentrate with forage available at all times.Case presentationThe lameness was found to […]

Timing in audiovisual speech perception: A mini review and new psychophysical data

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 33 δευτερόλεπτα

Abstract Recent influential models of audiovisual speech perception suggest that visual speech aids perception by generating predictions about the identity of upcoming speech sounds. These models place stock in the assumption that visual speech leads auditory speech in time. However, it is unclear whether and to what extent temporally-leading visual speech information contributes to perception. Previous studies exploring audiovisual-speech timing have relied upon psychophysical procedures that require artificial manipulation of cross-modal alignment or stimulus duration. We introdu...περισσότερα »

Observational cohort study of the natural history of Niemann-Pick disease type C in the UK: a 5-year update from the UK clinical database

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 33 δευτερόλεπτα

Background: Niemann-Pick disease type C (NP-C) is a rare neurovisceral lipid storage disorder characterised by progressive, disabling neurological symptoms and premature death in most patients. During the last decade, national cohort studies have accrued a great deal of data on the symptomatology and natural history of NP-C. Methods: In an observational cohort study, we present a substantial update based on the clinical presentation and follow-up of all known UK-based patients with a confirmed diagnosis of NP-C who have been tracked on an electronic database at the Department of G...περισσότερα »

Spinocerebellar ataxia 28: a novel AFG3L2 mutation in a German family with young onset, slow progression and saccadic slowing

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 33 δευτερόλεπτα

Abstract Background Spinocerebellar ataxia type 28 (SCA28) is related to mutations of the *ATPase family gene 3*-*like 2* gene (*AFG3L2*). To date, 13 private missense mutations have been identified in families of French, Italian, and German ancestry, but overall, the disorder seems to be rare in Europe. Here, we report a kindred of German ancestry with four affected family members presenting with slowly progressive ataxia, mild pyramidal tract signs and slow saccades. Methods After excluding repeat expansions in the genes for SCA1-3, 6-8, 10, 12, and 17, Sanger sequencing of the... περισσότερα »

“Central vessel sign” on 3T FLAIR* MRI for the differentiation of multiple sclerosis from migraine

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 33 δευτερόλεπτα

Abstract Objective The diagnosis of multiple sclerosis (MS) presently relies on radiographic assessments of imperfect specificity. Recent data using T2* methodology for the detection of the "central vessel sign" (CVS) in MS lesions suggests this novel MRI technique may distinguish MS from other disorders. Our aim was to determine if evaluation for CVS on 3T FLAIR* MRI differentiates MS from migraine. Methods Patients with MS or migraine and a prior brain MRI demonstrating at least two hyperintense lesions ≥3 mm were recruited. Exclusion criteria included any additional comorbidi... περισσότερα »

Eyeglasses elicit effects similar to face-like perceptual expertise: evidence from the N170 response

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 33 δευτερόλεπτα

Abstract Studies of event-related potentials show that the specific N170 response has become a stable electrophysiological hallmark of objects related to expertise in early perceptual processing. In the present study, we investigated whether eyeglasses can elicit N170 effects similar to those elicited by objects of expertise. Our results showed that the N170 response elicited by eyeglasses was larger than the response elicited by objects that do not generate perceptual expertise (e.g., houses). Importantly, we found that eyeglasses could produce a within-category N170 adaptation e... περισσότερα »

Sensorimotor integration is enhanced in dancers and musicians

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 33 δευτερόλεπτα

Abstract Studying individuals with specialized training, such as dancers and musicians, provides an opportunity to investigate how intensive practice of sensorimotor skills affects behavioural performance across various domains. While several studies have found that musicians have improved motor, perceptual and sensorimotor integration skills compared to untrained controls, fewer studies have examined the effect of dance training on such skills. Moreover, no study has specifically compared the effects of dance versus music training on perceptual or sensorimotor performance. To this...περισσότερα »

Subliminal trauma reminders impact neural processing of cognitive control in adults with developmental earthquake trauma: a preliminary report

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 33 δευτερόλεπτα

Abstract Little is known about the effects of developmental trauma on the neural basis of cognitive control among adults who do not have posttraumatic stress disorder. To examine this question, we used functional magnetic resonance imaging to compare the effect of subliminal priming with earthquake-related images on attentional control during a Stroop task in survivors of the 2008 Wenchuan earthquake in China (survivor group, survivors were adolescents at the time of the earthquake) and in matched controls (control group). We found that the survivor group showed greater activation...περισσότερα »

Cross-modal perceptual load: the impact of modality and individual differences

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 33 δευτερόλεπτα

Abstract Visual distractor processing tends to be more pronounced when the perceptual load (PL) of a task is low compared to when it is high [perpetual load theory (PLT); Lavie in J Exp Psychol Hum Percept Perform 21(3):451–468, 1995]. While PLT is well established in the visual domain, application to cross-modal processing has produced mixed results, and the current study was designed in an attempt to improve previous methodologies. First, we assessed PLT using response competition, a typical metric from the uni-modal domain. Second, we looked at the impact of auditory load on vi...περισσότερα »

Energies, Vol. 8, Pages 14197-14218: Designing an Incentive Contract Menu for Sustaining the Electricity Market

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 45 δευτερόλεπτα

This paper designs an incentive contract menu to achieve long-term stability for electricity prices in a day-ahead electricity market. A bi-level Stackelberg game model is proposed to search for the optimal incentive mechanism under a one-leader and multi-followers gaming framework. A multi-agent simulation platform was developed to investigate the effectiveness of the incentive mechanism using an independent system operator (ISO) and multiple power generating companies (GenCos). Further, a Q-learning approach was implemented to analyze and assess the response of GenCos to the inc... περισσότερα »

Catalysts, Vol. 5, Pages 2161-2222: Zeolite Membranes in Catalysis—From Separate Units to Particle Coatings

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 45 δευτερόλεπτα

Literature on zeolite membranes in catalytic reactions is reviewed and categorized according to membrane location. From this perspective, the classification is as follows: (i) membranes spatially decoupled from the reaction zone; (ii) packed bed membrane reactors; (iii) catalytic membrane reactors and (iv) zeolite capsuled catalyst particles. Each of the resulting four chapters is subdivided by the kind of reactions performed. Over the whole sum of references, the advantage of zeolite membranes in catalytic reactions in terms of conversion, selectivity or yield is evident. Further... περισσότερα »

IJMS, Vol. 16, Pages 29948-29970: Transcriptome Characterization for Non-Model Endangered Lycaenids, Protantigius superans and Spindasis takanosis, Using Illumina HiSeq 2500 Sequencing

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 45 δευτερόλεπτα

The Lycaenidae butterflies, Protantigius superans and Spindasis takanosis, are endangered insects in Korea known for their symbiotic association with ants. However, necessary genomic and transcriptomics data are lacking in these species, limiting conservation efforts. In this study, the P. superans and S. takanosis transcriptomes were deciphered using Illumina HiSeq 2500 sequencing. The P. superans and S. takanosis transcriptome data included a total of 254,340,693 and 245,110,582 clean reads assembled into 159,074 and 170,449 contigs and 107,950 and 121,140 unigenes, respectively....περισσότερα »

IJMS, Vol. 16, Pages 29980-29995: Dietary Compound Kaempferol Inhibits Airway Thickening Induced by Allergic Reaction in a Bovine Serum Albumin-Induced Model of Asthma

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 45 δευτερόλεπτα

Asthma is characterized by aberrant airways including epithelial thickening, goblet cell hyperplasia, and smooth muscle hypertrophy within the airway wall. The current study examined whether kaempferol inhibited mast cell degranulation and prostaglandin (PG) release leading to the development of aberrant airways, using an in vitro model of dinitrophenylated bovine serum albumin (DNP-BSA)-sensitized rat basophilic leukemia (RBL-2H3) mast cells and an in vivo model of BSA-challenged asthmatic mice. Nontoxic kaempferol at 10–20 μM suppressed β-hexosaminidase release and cyclooxygenas...περισσότερα »

Prospective study of predictors and consequences of insomnia: personality, lifestyle, mental health and work-related stressors

Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 56 δευτερόλεπτα

[image: S13899457.gif] Publication date: Available online 15 December 2015 *Source:*Sleep Medicine Author(s): Øystein Vedaa, Elfrid Krossbakken, Ingse Dagny Grimsrud, Bjørn Bjorvatn, Børge Sivertsen, Nils Magerøy, Ståle Einarsen, Ståle Pallesen ObjectiveTo prospectively investigate the reciprocal relationships between personality traits, lifestyle factors, mental health, sleepiness, and work-related stressors against insomnia.MethodsA total of 799 Norwegian shift-working nurses (mean age 33.2 years, 90% female) participated in this prospective cohort study. They were assessed on self...περισσότερα »

Don’t miss: 1st ecancer Symposium on Radiotherapy, Santiago, Chile, May 6-7th 2016 https://t.co/GbMiABya7r https://t.co/W2BlezuUBb

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα

Don’t miss: 1st ecancer Symposium on Radiotherapy, Santiago, Chile, May 6-7th 2016 https://t.co/GbMiABya7r https://t.co/W2BlezuUBb from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/677076329850884096 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1I8C1bk via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1k2aE6Y via IFTTT

Spots of bother

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα

Description A 24-year-old man presented with a 2-day history of a purpuric rash affecting his lower limbs, associated with fever, malaise and anorexia. He had fistulising, stricturing Crohn’s disease with an end ileostomy and two enterocutaneous fistulae requiring long-term parenteral nutrition (PN) via a single-lumen Hickman line. His only medication was analgaesia and vitamin B12. […]

Role of 18-Fludeoxyglucose positron emission tomography-computed tomography and subsequent panendoscopy in head and neck squamous cell carcinoma of unknown primary

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα

Objectives/Hypothesis Head and neck squamous cell carcinomas of unknown primary (HNSCCUP) accounts for up to 10% of presenting head and neck squamous cell carcinomas. Identification of the primary site allows for directed therapy. Where initial investigations have failed to locate the primary site, 18-fludeoxyglucose positron emission tomography-computed tomography (PET/CT) has emerged as a useful tool […]

Bilateral closed flexor pollicis longus musculotendinous junction ruptures

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα

We present a case of bilateral closed flexor pollicis longus musculotendinous junction ruptures. Our case suggests multifactorial aetiology and provides further evidence for genetic influences in musculotendinous junction injuries. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RoiQgu via IFTTT

Anterior surface opacification of intraocular lenses after Descemet’s stripping automated endothelial keratoplasty

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα

Descemet’s stripping automated endothelial keratoplasty (DSAEK) is today recognised as the surgical procedure of choice for corneal endothelial dysfunction.1 The triple procedure (either staged or combined), whereby cataract surgery can be performed at the same time as endothelial keratoplasty, is well suited for patients with Fuch’s endothelial dystrophy with decreased vision due to endothelial guttata, […]

Juvenile spondyloarthropathy: an important clinical lesson to remember

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα

Spondyloarthropathy (SpA) is a group of inflammatory conditions that include spondylitis, sacroiliitis, asymmetrical peripheral arthritis and enthesitis. This condition is known as juvenile SpA when the diagnosis is made in patients up to 16 years of age. Enthesitis is a highly specific feature that occurs more often in juvenile SpA than in the adult form. […]

An assessment of the potential health impacts of food reformulation

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα

An assessment of the potential health impacts of food reformulation European Journal of Clinical Nutrition advance online publication, December 16 2015. doi:10.1038/ejcn.2015.201 Authors: P Leroy, V Réquillart, L-G Soler & G Enderli from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NT15nd via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1k2h2LN via IFTTT

Fluid consumption, total water intake and first morning urine osmolality in Spanish adolescents from Zaragoza: data from the HELENA study

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα

Fluid consumption, total water intake and first morning urine osmolality in Spanish adolescents from Zaragoza: data from the HELENA study European Journal of Clinical Nutrition advance online publication, December 16 2015. doi:10.1038/ejcn.2015.203 Authors: I Iglesia, A M Santaliestra-Pasías, S Bel-Serrat, T Sadalla-Collese, M L Miguel-Berges & L A Moreno from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader […]

Locally advanced adenocarcinoma of the rectum presenting with necrotising fasciitis of the perineum: successful management with early aggressive surgery and multimodal therapy

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα

Colorectal cancer is a common malignant neoplasm and its treatment usually involves surgery associated, in some cases, depending on the staging, with chemoradiotherapy. Necrotising fasciitis of the perineum is a highly lethal infection of the perineum, perirectal tissues and genitals, requiring emergency surgical debridement, broad-spectrum antibiotics and control of sepsis. We present the case of […]

Sarcopenia and length of hospital stay

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα

Sarcopenia and length of hospital stay European Journal of Clinical Nutrition advance online publication, December 16 2015. doi:10.1038/ejcn.2015.207 Authors: A S Sousa, R S Guerra, I Fonseca, F Pichel & T F Amaral from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NT16aD via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1k2gZPS via […]

A rare cause of recurrent wheeze and seizures

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα

A 34-year-old woman presented with recurrent attacks of breathlessness and seizures. The patient’s condition worsened during the course of her hospital stay, as a result of which she had to be intubated twice. Radiological studies showed a mass in the trachea and the subsequent biopsy of the mass revealed an infiltrating carcinoma with morphological features […]

Dietary under-reporting: what foods and which meals are typically under-reported?

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα

Dietary under-reporting: what foods and which meals are typically under-reported? European Journal of Clinical Nutrition advance online publication, December 16 2015. doi:10.1038/ejcn.2015.204 Authors: L Gemming & C Ni Mhurchu from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NwY1cI via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1k2gZzy via IFTTT

Stents in patients with esophageal cancer before chemoradiotherapy: high risk of complications and no impact on the nutritional status

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα

Stents in patients with esophageal cancer before chemoradiotherapy: high risk of complications and no impact on the nutritional status European Journal of Clinical Nutrition advance online publication, December 16 2015. doi:10.1038/ejcn.2015.206 Authors: S Mão-de-Ferro, M Serrano, S Ferreira, I Rosa, P Lage, D P Alexandre, J Freire, L Mirones, R Casaca, A Bettencourt & A […]

Haemophilia A in a major trauma patient

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα

Haemophilia A is a coagulopathy with an absence or functional deficiency of coagulation factor VIII. The disease can be subdivided into a congenital form (incidence 1:10 000–1:20 000) and an acquired form (incidence 1:1 000 000). Both forms present an increased risk of bleeding even in low-impact trauma in severe cases of haemophilia A. The […]

Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the Fc receptor γ-chain

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα

Basophils are regarded as important effector cells that contribute to allergic inflammation and induction of TH2 responses because they generate large amounts of IL-4 in IgE-dependent and IgE-independent manners.1,2 Although the IgE-dependent high-affinity IgE receptor (FcεRI)–mediated mechanisms of basophil and mast cell activation, in which the Fc receptor γ-chain (FcRγ) and spleen tyrosine kinase (Syk) […]

The effect of dietary counselling on food intakes in pregnant women at risk for gestational diabetes: a secondary analysis of a randomised controlled trial RADIEL

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα

The effect of dietary counselling on food intakes in pregnant women at risk for gestational diabetes: a secondary analysis of a randomised controlled trial RADIEL European Journal of Clinical Nutrition advance online publication, December 16 2015. doi:10.1038/ejcn.2015.205 Authors: A Valkama, S Koivusalo, J Lindström, J Meinilä, H Kautiainen, B Stach-Lempinen, K Rönö, M Klemetti, M […]

Diagnostic performance of body mass index to identify adiposity in women

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα

Diagnostic performance of body mass index to identify adiposity in women European Journal of Clinical Nutrition advance online publication, December 16 2015. doi:10.1038/ejcn.2015.211 Authors: A Gába & M Přidalová from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NwXZS1 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1k2h2vd via IFTTT

CAA Prizes Announcement for 2016

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NwXU0E via IFTTT

Study of Cavity Modal Damping: A Numerical Methodology for Acoustic Evaluation Using the Finite Element Method in Vehicle Bodies Based on Experimental Tests

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

This work focuses on finding a numerical solution for vehicle acoustic studies and improving the usefulness of the “Numerical experimental” parameters for the development stage of a new automotive project. Specifically, this research addresses the importance of cavity modal damping for vehicle exerts during numerical studies. This research then seeks to suggest standardized parameter values […]

Sound Pressure Levels measured in Fitness Gyms in Brazil

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Fitness gyms are venues where people seek health and leisure. Therefore, it is important to know the sound pressure levels (SPLs) usually applied in these environments. This study assessed the range of SPLs measured in ten fitness gyms. The measurements were taken during the following gym workouts: jumping, swinging, localized and aerobic exercise. The measurements […]

Impact of Auditory Attention on the Efferent Auditory System in the Absence of Real Auditory Targets

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Previous studies have compared visual and auditory attention to no-task conditions and have demonstrated an attention driven modulation of the efferent auditory system (De Boer & Thornton, 2007; Maison, Micheyl, & Collet, 2001). However, it is unclear whether these effects are modality-specific or a result of generalized attentional processes. In the present study, 16 young […]

CME: General Practice Highlights and Advances

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα

[image: DG ME] General Practice Highlights in Diabetes Credit: 1.00 CME IMPROVING OUTCOMES IN CONGENITAL AND ACQUIRED LIPODYSTROPHY: Best Practices in Diagnosis and Management Global Education Group Advances in General Practice Medical Education and Presentations Credit: 1.00 CME Massachusetts Medical Society Acid–Base Problems in Diabetic Ketoacidosis Credit: 1.25 CME Vindico Psych Evidence-based Consults Publication Leslie Citrome, MD, MPH Credit: 1.00 CME Nemours Treating Childhood Anxiety: All you need to know but were “AF... περισσότερα »

Spinocerebellar ataxia 28: a novel AFG3L2 mutation in a German family with young onset, slow progression and saccadic slowing

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Abstract Background Spinocerebellar ataxia type 28 (SCA28) is related to mutations of the ATPase family gene 3–like 2 gene (AFG3L2). To date, 13 private missense mutations have been identified in families of French, Italian, and German ancestry, but overall, the disorder seems to be rare in Europe. Here, we report a kindred of German ancestry […]

IL-1β mediating high mobility group box protein-1 expression in condylar chondrocyte during temporomandibular joint inflammation

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Background Temporomandibular joint (TMJ) osteoarthritis(OA)characterized with cartilage degen-eration is associated with inflammation. High mobility group box chromosomal protein-1(HMGB-1)is a potent mediator of inflammation and the trigger of OA. The expression of HMGB-1 in TMJ OA was uncovered, but the role of HMGB-1 in TMJ cartilage degeneration is not fully understood. In this study, the regulation […]

Immunoexpression of growth factors and receptors in polymorphous low-grade adenocarcinoma

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Background Polymorphous low-grade adenocarcinoma (PLGA) is a rare malignant tumor that usually arises in the minor salivary glands. Growth factors are cell-secreted peptides that regulate biological processes such as growth, proliferation, and differentiation. In salivary gland tumors, immunoexpression of growth factors and their receptors is associated with cell proliferation, malignant transformation, and tumor invasion. This […]

Role of 18-Fludeoxyglucose positron emission tomography-computed tomography and subsequent panendoscopy in head and neck squamous cell carcinoma of unknown primary

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Objectives/Hypothesis Head and neck squamous cell carcinomas of unknown primary (HNSCCUP) accounts for up to 10% of presenting head and neck squamous cell carcinomas. Identification of the primary site allows for directed therapy. Where initial investigations have failed to locate the primary site, 18-fludeoxyglucose positron emission tomography-computed tomography (PET/CT) has emerged as a useful tool […]

“Central vessel sign” on 3T FLAIR* MRI for the differentiation of multiple sclerosis from migraine

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Abstract Objective The diagnosis of multiple sclerosis (MS) presently relies on radiographic assessments of imperfect specificity. Recent data using T2* methodology for the detection of the “central vessel sign” (CVS) in MS lesions suggests this novel MRI technique may distinguish MS from other disorders. Our aim was to determine if evaluation for CVS on 3T […]

The role of orthodontics in the regeneration of the degenerated dentition

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Summary The demand for regeneration of a degenerated dentition has been increasing as a result of the development of societies, where the life expectancy is increasing and fighting age-related changes is in focus. Whereas removable dentures were acceptable and considered a norm earlier, patients do, to an increasing degree,demand fixed prosthetics; consequently, the development of […]

Validity of Submaximal Step Tests to Estimate Maximal Oxygen Uptake in Healthy Adults

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Abstract Background Aerobic capacity (VO2max) is a strong predictor of health and fitness and is considered a key physiological measure in the healthy adult population. Submaximal step tests provide a safe, simple and ecologically valid means of assessing VO2max in both the general population and a rehabilitation setting. However, no studies have attempted to synthesize […]

Agility in Team Sports: Testing, Training and Factors Affecting Performance

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Abstract Background Agility is an important characteristic of team sports athletes. There is a growing interest in the factors that influence agility performance as well as appropriate testing protocols and training strategies to assess and improve this quality. Objective The objective of this systematic review was to (1) evaluate the reliability and validity of agility […]

Cost analysis of asthma maintenance medications in a veteran population

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Asthma is a disease that is characterized by hyperresponsiveness of bronchi due to various stimuli. An estimated 22.9 million Americans have asthma. Asthma accounts for 17 million ambulatory care visits and 456,000 hospitalizations per year.1 It effects 7.7% of US adults and 9.4% of US children.2 In the United States, in 2007, the annual total […]

Novel Therapies to Inhibit Mucus Synthesis and Secretion in Airway Hypersecretory Diseases

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Background: In asthma and chronic obstructive pulmonary disease (COPD), airway mucus hypersecretion contributes to impaired mucociliary clearance, mucostasis and, potentially, the development of mucus plugging of the airways. Summary: Excess mucus production can be targeted via therapies that focus on inhibition mucin synthesis, via reducing expression of mucin (MUC) genes, and/or inhibition of mucin secretion […]

Issue Information – TOC

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα

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A Few Secrets About Teeth Whitening

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Within the project 10 years the bag of teeth whitening, both mastery the dental assignment and at home, has changed immensely. Essentially, competent are two different methods to effect whiter teeth: dental (in-office) whitening, and an at home treatment. Discover a few secrets about teeth whitening that your dentist hopes I’ll never expound you! METHOD #1: DENTAL (IN-OFFICE) TEETH WHITENING I can tell you from first-hand experience, dentists avidity the patient who wants to rest assured a teeth whitening procedure notoriety the dental office. Back in the early ’90’s adept was on... περισσότερα »

Prelemniscal Radiations: A New Reliable Landmark of the Thalamic Nucleus Ventralis Intermedius Location?

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα

*Background:* The thalamic nucleus ventralis intermedius (Vim nucleus) is the main surgical target for the management of intractable tremor. The Vim nucleus cannot be reliably located with routine stereotactic imaging, and so targeting relies on indirect coordinates. *Objective:* We propose to investigate if colored fractional anisotropy (FA) mapping can help to locate the Vim nucleus by identifying its borders, particularly the prelemniscal radiations (Raprl) that lie below and behind the nucleus. *Method:* We retrospectively reviewed the colored FA maps for 18 consecutive patients... περισσότερα »

Die Persönlichkeit von Attentätern

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Terrorismus In Zeiten des Terrors stellen sich viele die Frage: Was macht Menschen zu Attentätern? Psychisch krank sind die wenigsten, meinen einige Psychiater. Sie haben die Persönlichkeiten von extremistischen Gewalttätern analysiert – und mehrere klassische Täterprofile ausfindig gemacht. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QptRhH via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros …

Issue Information – TOC

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TPxU4A via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1NwRWwT via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QM8e9K via IFTTT

Lithium- Sensitive Store-Operated Ca2+ Entry in the Regulation of FGF23 Release

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Background/Aims: Lithium, a widely used drug for the treatment of mood disorders, has previously been shown to stimulate the release of fibroblast growth factor FGF23, a powerful regulator of 1,25(OH)2D3 formation and mineral metabolism. The cellular mechanisms involved have remained elusive. Lithium has been shown to modify Ca2+ signaling. In a wide variety of cells, …

Study identifies potential treatment target for IDH1-mutant cancers https://t.co/RC3wAFtAn8

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Study identifies potential treatment target for IDH1-mutant cancers https://t.co/RC3wAFtAn8 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/677067178139455488 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1NwRWgo via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1k2aBs5 via IFTTT

Assessment of Estradiol Response after Depot Triptorelin Administration in Girls with Central Precocious Puberty

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Background: Estradiol at baseline or after a classical gonadotropin-releasing hormone test did not reflect ovarian steroidogenesis in central precocious puberty (CPP) girls. Aims: To evaluate estradiol response to depot triptorelin, both at start and during therapy to determine how active ovarian steroidogenesis is at pubertal stage and under therapy. Methods: A prospective study was performed …

Evaluation and management of lead exposure

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Abstract Lead, which is widely used in industry, is a common element found in low concentrations in the Earth’s crust. Implementations to reduce environmental lead concentrations have resulted in a considerable reduction of lead levels in the environment (air) and a sustained reduction in the blood lead levels of the average citizen. However, people are …

Kombiniert in die Hypoglykämie

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Vitamin-K-Antagonist plus SH Diabetiker, die mit Sulfonylharnstoffen (SH) behandelt werden und zusätzlich einen Vitamin-K-Antagonisten benötigen, müssen verstärkt mit Hypoglykämien rechnen. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OvWJOX via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QM8dT8 via IFTTT

Effects of peripheral nerve injury on parvalbumin expression in adult rat dorsal root ganglion neurons

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Background: Parvalbumin (PV) is a calcium binding protein that identifies a subpopulation of proprioceptive dorsal root ganglion (DRG) neurons. Calcitonin gene-related peptide (CGRP) is also expressed in a high proportion of muscle afferents but its relationship to PV is unclear. Little is known of the phenotypic responses of muscle afferents to nerve injury. Sciatic nerve …

Don’t miss: 1st ecancer Symposium on Radiotherapy, Santiago, Chile, May 6-7th 2016 https://t.co/GbMiABya7r https://t.co/W2BlezuUBb

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Don’t miss: 1st ecancer Symposium on Radiotherapy, Santiago, Chile, May 6-7th 2016 https://t.co/GbMiABya7r https://t.co/W2BlezuUBb from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/677076329850884096 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1I8C1bk via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1k2aE6Y via IFTTT

Interactions between attention-grabbing brain networks weak in ADHD, study says

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Interactions between three brain networks that help people pay attention are weaker than normal in children with attention-deficit hyperactivity disorder, according to a new study from the Stanford… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lOW44C via IFTTT

Anti Cellulite Treatments 41

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Easy Anti Cellulite Treatments Oh, cellulite that bane of perfect flesh woman-wide. But what is cellulite? And, supplementary importantly, how incubus we commence it trial away? In this article, I will examine some of the leading wares in the anti cellulite design market, with real scientific testing on how they work if they work at all. Lets perform to the lab. First off, lets know the enemy. Cellulite is a common condition that occurs in the majority of women as they age past youthfulness. The adipose fat deposits fix their legs, stomach and pelvis becomes dimpled further uneve... περισσότερα »

Ex vivo motility in the base of the rabbit caecum and its associated structures: an electrophysiological and spatiotemporal analysis

Alexandros G. SfakianakisστοEvolutionary PhysiologyΠριν από 1 ώρα

Abstract We examined the coordination between contractile events at different sites in the basal portion of the rabbit caecum and its associated structures that were identified by electrophysiological recordings with simultaneous one-dimensional, and a novel two-dimensional, spatiotemporal mapping technique. The findings of this work provide evidence that the caecum and proximal colon/ampulla coli act reflexly to augment colonic outflow when the caecum is distended and mass peristalsis instituted, the action of the latter overriding the inherent rhythm and direction of haustral pro... περισσότερα »

Assessment of Estradiol Response after Depot Triptorelin Administration in Girls with Central Precocious Puberty

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα

Background: Estradiol at baseline or after a classical gonadotropin-releasing hormone test did not reflect ovarian steroidogenesis in central precocious puberty (CPP) girls. Aims: To evaluate estradiol response to depot triptorelin, both at start and during therapy to determine how active ovarian steroidogenesis is at pubertal stage and under therapy. Methods: A prospective study was performed […]

Evaluation and management of lead exposure

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα

Abstract Lead, which is widely used in industry, is a common element found in low concentrations in the Earth’s crust. Implementations to reduce environmental lead concentrations have resulted in a considerable reduction of lead levels in the environment (air) and a sustained reduction in the blood lead levels of the average citizen. However, people are […]

All About Links — Interview With Link Building Expert , Bob Gladstein

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα

Julia: Welcome Bob. Thank you being enticing the time to interpretation my questions about ten on building. I’m deal to buck right mark quiz you why Web sites admiration links? Bob: skillful are a number of reasons to have links pointing to your site. But lets start with the reason they were created in the […]

Novel Therapies to Inhibit Mucus Synthesis and Secretion in Airway Hypersecretory Diseases

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα

Background: In asthma and chronic obstructive pulmonary disease (COPD), airway mucus hypersecretion contributes to impaired mucociliary clearance, mucostasis and, potentially, the development of mucus plugging of the airways. Summary: Excess mucus production can be targeted via therapies that focus on inhibition mucin synthesis, via reducing expression of mucin (MUC) genes, and/or inhibition of mucin secretion […]

Issue Information – TOC

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα

from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TPxU4A via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1NwRWwT via IFTTT

Issue Information – Journal Information

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα

from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1O8gTEu via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1I8BZQM via IFTTT

Kombiniert in die Hypoglykämie

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα

Vitamin-K-Antagonist plus SH Diabetiker, die mit Sulfonylharnstoffen (SH) behandelt werden und zusätzlich einen Vitamin-K-Antagonisten benötigen, müssen verstärkt mit Hypoglykämien rechnen. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OvWJOX via IFTTT

Die Persönlichkeit von Attentätern

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα

Terrorismus In Zeiten des Terrors stellen sich viele die Frage: Was macht Menschen zu Attentätern? Psychisch krank sind die wenigsten, meinen einige Psychiater. Sie haben die Persönlichkeiten von extremistischen Gewalttätern analysiert – und mehrere klassische Täterprofile ausfindig gemacht. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QptRhH via IFTTT

Don’t miss: 1st ecancer Symposium on Radiotherapy, Santiago, Chile, May 6-7th 2016 https://t.co/GbMiABya7r https://t.co/W2BlezuUBb

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα

Don’t miss: 1st ecancer Symposium on Radiotherapy, Santiago, Chile, May 6-7th 2016 https://t.co/GbMiABya7r https://t.co/W2BlezuUBb from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/677076329850884096 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1I8C1bk via IFTTT

Role of 18-Fludeoxyglucose positron emission tomography-computed tomography and subsequent panendoscopy in head and neck squamous cell carcinoma of unknown primary

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα

Objectives/Hypothesis Head and neck squamous cell carcinomas of unknown primary (HNSCCUP) accounts for up to 10% of presenting head and neck squamous cell carcinomas. Identification of the primary site allows for directed therapy. Where initial investigations have failed to locate the primary site, 18-fludeoxyglucose positron emission tomography-computed tomography (PET/CT) has emerged as a useful tool […]

Auto-pilot Link Building Strategy For Content-sites

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 1 ώρα

OK, this is what I consider a very effective method to get people to link to you without you having to ask them to reach so. The capital part is that, people commit link to you due to your highly targeted keyword. I happen to discover this method following seeing the results that I get on one of my website. I don’t have quota inborn reason for doing actual that gate on my website, but it seems to enterprise like magic. Sometimes, I hunt for people who are linking to me by looking at my referrers. You can also do that by checking your website statistics. Sometimes, I do a link p... περισσότερα »

Are Paid Surveys A Waste Of Your Time

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Recently ,while visiting by oneself of my favorite business forums, I ran across some lively comments concerning paid surveys. The gyst of these comments was that taking online surveys is a waste of time. Here is my gloss to those comments… …. Just because you didn’t carry out any money with surveys, that doesn’t mean that they are a waste of time. Like any other online opportunity, it takes time also effort to figure an winnings with surveys. Many people who have failed, say the same thing about SFI, Goji, Empowerism, and dozens of unalike online reach at familiar job opportun...περισσότερα »

Authentic Designer Handbags 16

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 1 ώρα

When you are in the market for true designer handbags you positively inclination to make absolute that you are creation a sound jeopardy. Of course, you cant go wrong by choosing an exclusive since a knock off designer purse. You contract find pretty sublime replicas but all supremacy all the authentic designer handbags offer fresh value for the money. Replica designer purses can set you move quite a few bucks. Why not invest a little more predominance the undoubted deal? The genius of the legitimate designer handbags is beyond compare further you will have a better means in the... περισσότερα »

Anti-cellulite Aromatherapy

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 2 ώρες

ï»؟Anti-cellulite Aromatherapy Many manliness fight the phenomenon of cellulite and it definitely affects the emotional position among themselves. Many cosmetic companies promise you cellulite disappear cache thousands of products, creams, lotions, but you asked yourself what is thoroughly done to rumble to eliminate cellulite? Doctors use the term cellulite to express inflammation of the tissue cells, generally as a sentence of a wound became infected. Cosmetics, Women’s magazines multiplied therapists use the term to describe the sagaciousness of liquid toxic wilderness ma...περισσότερα »

An Ideal Reverse Phone Lookup Service To Trace Back Owners Instantly

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 2 ώρες

ï»؟An Ideal differing Phone Lookup Service To Trace Back Owners Instantly At times you may be getting mad calls and you may be struggling to stick an end now such an irritating jangle. It is not a difficult task to seek now the pranksters who is constantly troubling you. supplementary than that you may be drag a need of the owners’ details since some other reasons, what ever the reason may be, you culpability take assistance of reverse phone lookup websites also particularize back callers immediately. It is an online telephone directory that has the strapping database of indica... περισσότερα »

Therapiesicherheit bei Verwendung nicht Vitamin-K-abhängiger oraler Antikoagulanzien bei Patienten mit Vorhofflimmern

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

Zusammenfassung Nicht Vitamin-K-abhängige orale Antikoagulanzien (NOAK) sind für die Schlaganfallprävention bei Vorhofflimmern mittlerweile etabliert. Verglichen mit Vitamin-K-Antagonisten (VKA) ist ihre Effektivität mindestens gleichwertig, wenn nicht sogar besser. Das Blutungsrisiko ist für die NOAK geringer als für VKA, wobei insbesondere eine deutliche Überlegenheit bei der Vermeidung intrazerebraler Blutungen besteht. Der klinische Verlauf ist nach einer NOAK-assoziierten […]

Novel Therapies to Inhibit Mucus Synthesis and Secretion in Airway Hypersecretory Diseases

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

Background: In asthma and chronic obstructive pulmonary disease (COPD), airway mucus hypersecretion contributes to impaired mucociliary clearance, mucostasis and, potentially, the development of mucus plugging of the airways. Summary: Excess mucus production can be targeted via therapies that focus on inhibition mucin synthesis, via reducing expression of mucin (MUC) genes, and/or inhibition of mucin secretion […]

Responding to the 2014 Ebola Outbreak: The Value of Effective Interprofessional Communication During Emergency Response

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

Letter Bobbie Jo Newell, Jessica C. Pittman, H. Pamela Pagano, John S. Barron, Bettye A. Apenteng Disaster Medicine and Public Health Preparedness, FirstView Article(s), 2 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UyqK5D via IFTTT

SPAK and OSR1 Sensitive Kir2.1 K+ Channels

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

Background/Aims: Kir2.1 (KCNJ2) channels are expressed in neurons, skeletal muscle and cardiac tissue and maintain the resting membrane potential. The activity of those channels is regulated by diverse signalling molecules. The present study explored whether Kir2.1 channels are sensitive to the transporter and channels regulating kinases SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase […]

Lithium- Sensitive Store-Operated Ca2+ Entry in the Regulation of FGF23 Release

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

Background/Aims: Lithium, a widely used drug for the treatment of mood disorders, has previously been shown to stimulate the release of fibroblast growth factor FGF23, a powerful regulator of 1,25(OH)2D3 formation and mineral metabolism. The cellular mechanisms involved have remained elusive. Lithium has been shown to modify Ca2+ signaling. In a wide variety of cells, […]

Assessment of Estradiol Response after Depot Triptorelin Administration in Girls with Central Precocious Puberty

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

Background: Estradiol at baseline or after a classical gonadotropin-releasing hormone test did not reflect ovarian steroidogenesis in central precocious puberty (CPP) girls. Aims: To evaluate estradiol response to depot triptorelin, both at start and during therapy to determine how active ovarian steroidogenesis is at pubertal stage and under therapy. Methods: A prospective study was performed […]

Evaluation and management of lead exposure

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

Abstract Lead, which is widely used in industry, is a common element found in low concentrations in the Earth’s crust. Implementations to reduce environmental lead concentrations have resulted in a considerable reduction of lead levels in the environment (air) and a sustained reduction in the blood lead levels of the average citizen. However, people are […]

Effects of peripheral nerve injury on parvalbumin expression in adult rat dorsal root ganglion neurons

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

Background: Parvalbumin (PV) is a calcium binding protein that identifies a subpopulation of proprioceptive dorsal root ganglion (DRG) neurons. Calcitonin gene-related peptide (CGRP) is also expressed in a high proportion of muscle afferents but its relationship to PV is unclear. Little is known of the phenotypic responses of muscle afferents to nerve injury. Sciatic nerve […]

Interactions between attention-grabbing brain networks weak in ADHD, study says

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

Interactions between three brain networks that help people pay attention are weaker than normal in children with attention-deficit hyperactivity disorder, according to a new study from the Stanford… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lOW44C via IFTTT

Anaesthesia for oncological surgery – can it really influence cancer recurrence?

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NwK7HJ via IFTTT

All About Links — Interview With Link Building Expert , Bob Gladstein

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Julia: Welcome Bob. Thank you being enticing the time to interpretation my questions about ten on building. I’m deal to buck right mark quiz you why Web sites admiration links? Bob: skillful are a number of reasons to have links pointing to your site. But lets start with the reason they were created in the first place. The distinguishing purpose of the Internet was to enable the sharing of tip. For example, if a scholarly paper existed on a server at the University of California, and a professor at Oxford wanted to bring out it, the Internet made that instantly viable. Now, if th... περισσότερα »

Issue Information - TOC

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 2 ώρες

from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1TPxU4A via IFTTT

Issue Information - Journal Information

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 2 ώρες

[image: cover.gif?v=1&s=1e612ed8f4c3a3a028ee4e42] from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1O8gTEu via IFTTT

andy warhol paintings

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 2 ώρες

Andy Warhol Paintings: The Pinnacle of Pop In 1928, Pittsburgh, Pennsylvania hosted the birth of a man that would soon change the face of modern art. Named Andrew Warhola, this was a man that was destined to rule Pop art and define its parameters, or most aptly, blur its lines. Andy Warhol paintings today are considered as priceless collectors items and even replicas of his art work are considered as great additions to any home. What fueled Warhols success was his paintings of pop culture and icons and this series began in the 1960s. His first series of paintings were silkscreen im... περισσότερα »

A Guide To Learning Chinese Online

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 2 ώρες

A Guide To Learning Chinese Online If what’s what the Chinese language is on your list of things to do, then consider using the first tool at your fingertipsyour computer. Today, the internet is chocked full of a multitude of a anomaly of instructions for learning Chinese. Each hole offers something unique and helpful to that site, however, there are of course, some maintained with a more serious benefit agency learning and others, well, just plain frumpy. Before you begin, be prepared to do a lot of surfing from your favorite explore engines and bookmarking the ones appropriate ... περισσότερα »