Rejuvenation of the deep superior sulcus in the eyelid
Summary Background Nowadays, a number of patients seeking cosmetic surgery for their sunken upper eyelid are increasing. The aim of this study was to provide an overview of the various treatment options for sunken superior sulcus with reported complications and to discuss effective methods for treatment. Methods In a PubMed search, studies involving patients undergoing correction of sunken superior sulcus with various treatment options were included. Results A systematic search revealed twelve articles representing 680 cases that satisfied inclusion criteria. All were case serie...περισσότερα »
Non-keratinocyte SNAP29 influences epidermal differentiation and hair follicle formation in mice
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Phycosaccharide AI a Mixture of Alginate Polysaccharides Increases Stem Cell Proliferation in Aged Keratinocytes
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Detection by spinning-disk imaging of epithelial precursor cells in dissected human hair follicles
Abstract Human hair follicles (hHF) consist of two distinct compartments (dermal and epithelial) whose interaction is essential for hHF morphogenesis. Maintenance and function of these two compartments depend on the presence and activity of several stem cell populations. In the epithelial compartment a stem cell reservoir has originally been identified in the bulge in rodents (1). In human, several reservoirs of keratinocytes with clonogenic potential are described in the outer root sheath (ORS). Cells from the upper ORS are K19+, CD200high, CD271low, CD34- whereas the lower part ...περισσότερα »
UVB irradiation induces HMGB1 expression in keratinocytes without promoting apoptosis
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Long-term skin regeneration in xenografts from iPSC teratoma-derived human keratinocytes
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A Primer for Studying Cell Cycle Dynamics of the Human Hair Follicle
Abstract The cell cycle is of major importance to human hair follicle (HF) biology. Not only is continuously active cell cycling required to facilitate healthy hair growth in anagen VI HFs, but perturbations in the cell cycle are likely to be of significance in HF pathology (i.e. in scarring, non-scarring, chemotherapy induced and androgenic alopecias). However cell cycle dynamics of the human hair follicle (HF) are poorly understood in contrast to what is known in mouse. The aims of this method review are two fold; principally to address this gap we present a primer to introduce ... περισσότερα »
FK506 regulates pigmentation by maturing the melanosome and facilitating their transfer to keratinocytes
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Comparison of the C-Mac video laryngoscope with the McGrath Series 5 video laryngoscope concerning an extremely difficult airway
Comparison of the C-Mac video laryngoscope with the McGrath Series 5 video laryngoscope concerning an extremely difficult airway: PDF : https://journals.viamedica.pl/anaesthesiology_intensivetherapy/article/view/AIT.2016.0007/31156
Tissue oximetry
in anaesthesia and intensive care: Conventional monitoring during surgery and intensive care is not sufficiently sensitive to detect acute changes in vital organs perfusion, while its good quality is critical for maintaining their function. Disturbed vital organ perfusion may lead to the development of postoperative complications, including neurological sequel and renal failure. Near-infra-red spectroscopy (NIRS) represents one of up-to-date techniques of patient monitoring which is commonly used for the assessment of brain oximetry in thoracic aorta surgery, and – increasingly mo... περισσότερα »
Allergic skin sensitization promotes eosinophilic esophagitis
via the interleukin-33-basophil axis in mice via Allergy and Clinical Immunology Publication date: Available online 19 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Nicholas Venturelli, Willem S. Lexmond, Asa Ohsaki, Samuel Nurko, Hajime Karasuyama, Edda Fiebiger, Michiko K. Oyoshi BackgroundEosinophilic esophagitis (EoE) is an allergic inflammatory disorder characterized by the accumulation of eosinophils in the esophagus. EoE often coexists with atopic dermatitis (AD), a chronic inflammatory skin disease. The impaired skin barrier in AD has been suggested ...περισσότερα »
Inter-observer Variation in the Pathologic Identification of Extranodal Extension in Nodal Metastasis from Papillary Thyroid Carcinoma.
*Inter-observer Variation in the Pathologic Identification of Extranodal Extension in Nodal Metastasis from Papillary Thyroid Carcinoma.* Thyroid. 2016 Apr 18; Authors: Du E, Wenig B, Su HK, Rowe ME, Haser GC, Asa SL, Baloch ZW, Faquin WC, Giordano TJ, Ghossein R, LiVolsi VA, Lloyd RV, Mete O, Ozbek U, Rosai J, Suster S, Thompson LD, Turk A, Urken ML Abstract BACKGROUND: Extranodal extension (ENE) in lymph node metastases has been shown to worsen the prognosis of papillary thyroid cancer (PTC). Despite the clinical significance of ENE, there are no stringent criteria for its micr... περισσότερα »
ROS1-Rearrangement in Thyroid Cancer.
*<i>ROS1</i>-Rearrangement in Thyroid Cancer.* Thyroid. 2016 Apr 18; Authors: Ritterhouse LL, Wirth LJ, Randolph G, Sadow PM, Ross DS, Liddy W, Lennerz JK Abstract <b>Background</b>: Aberrations involving the <i>ROS1</i> gene have not been reported in thyroid cancer. We present a case of <i>ROS1</i>-associated thyroid cancer with unique and aggressive characteristics. <b>Patient findings</b>: A 24 year-old athlete presented with a 3.5 cm left paramedian upper neck mass. Open biopsy demonstrated a papillary thyroid carcinoma arising in the pyramidal lobe. Additional imaging reveal... περισσότερα »
The natural history of subclinical hyperthyroidism in Graves' disease - the rule of thirds.
*The natural history of subclinical hyperthyroidism in Graves' disease - the rule of thirds.* Thyroid. 2016 Apr 18; Authors: Zhyzhneuskaya S, Addison C, Tsatlidis V, Weaver IU, Razvi S Abstract BACKGROUND: There is little information regarding the natural history of subclinical hyperthyroidism (SH) due to Graves' disease (GD). METHODS: A prospective analysis of patients with SH due to GD between 2007 and 2013 with at least 12 months of follow-up. SH was diagnosed if serum TSH was below the laboratory reference range (0.4 - 4.0 mU/L) and when thyroid hormones were normal. GD was co...περισσότερα »
Health related quality of life following the treatment of oropharyngeal cancer by transoral laser.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*Health related quality of life following the treatment of oropharyngeal cancer by transoral laser.* Eur Arch Otorhinolaryngol. 2016 Apr 18; Authors: Rogers SN, Pinto RS, Lancaster J, Bekiroglu F, Lowe D, Tandon S, Jones TM Abstract In 2006, our Institution changed the treatment strategy for small volume primary oropharyngeal tumours to transoral laser microsurgery (TOLM). The main aim of this cohort study was to report the health related quality of life (HRQOL) at around 2 years following TOLM in consecutive patients treated from July 2006 through April 2013. The University of W... περισσότερα »
Does securin expression have significance in prognostication of oral tongue cancer? A pilot study.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*Does securin expression have significance in prognostication of oral tongue cancer? A pilot study.* Eur Arch Otorhinolaryngol. 2016 Apr 18; Authors: Heikkinen I, Almangush A, Hagström J, Bello IO, Kauppila JH, Mäkinen LK, Haglund C, Nieminen P, Salo T, Leivo I Abstract The proliferation marker, securin, is involved in the progression of many carcinomas. However, its expression in oral tongue squamous cell carcinoma (OTSCC) has not been previously studied. We examined securin expression by immunohistochemistry in OTSCC. A total of 93 cases treated for OTSCC were included in this ... περισσότερα »
Health related quality of life following the treatment of oropharyngeal cancer by transoral laser.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
*Health related quality of life following the treatment of oropharyngeal cancer by transoral laser.* Eur Arch Otorhinolaryngol. 2016 Apr 18; Authors: Rogers SN, Pinto RS, Lancaster J, Bekiroglu F, Lowe D, Tandon S, Jones TM Abstract In 2006, our Institution changed the treatment strategy for small volume primary oropharyngeal tumours to transoral laser microsurgery (TOLM). The main aim of this cohort study was to report the health related quality of life (HRQOL) at around 2 years following TOLM in consecutive patients treated from July 2006 through April 2013. The University of W... περισσότερα »
Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid cancer.
*Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid cancer.* FEBS J. 2016 Apr 19; Authors: Liu L, Yang J, Zhu X, Li D, Lv Z, Zhang X Abstract The long non-coding RNA H19 is overexpressed in many cancers and acts as an oncogene. Here, we investigated the role of H19 in thyroid carcinogenesis and its relation to microRNA miR-17-5p and its target gene YES1. H19 expression was higher in tumor samples and in thyroid cancer cell lines than non-tumor tissues and normal thyroid cells. H19 knockdown and ectopic expression in the TPC-1 and NIM thyro... περισσότερα »
Association of multifocality, tumor number, and total tumor diameter with clinicopathological features in papillary thyroid cancer.
*Association of multifocality, tumor number, and total tumor diameter with clinicopathological features in papillary thyroid cancer.* Endocrine. 2016 Apr 18; Authors: Tam AA, Özdemir D, Çuhacı N, Başer H, Aydın C, Yazgan AK, Ersoy R, Çakır B Abstract Tumor multifocality is not an unusual finding in papillary thyroid carcinoma (PTC), but its clinical significance is controversial. In this study, we aimed to evaluate impact of multifocality, tumor number, and total tumor diameter on clinicopathological features of PTC. Medical records of 912 patients who underwent thyroidectomy and... περισσότερα »
32nd International Austrian Winter Symposium : Zell am See, the Netherlands. 20-23 January 2016.
*32nd International Austrian Winter Symposium : Zell am See, the Netherlands. 20-23 January 2016.* EJNMMI Res. 2016 Apr;6(Suppl 1):32 Authors: Langsteger W, Rezaee A, Loidl W, Geinitz HS, Fitz F, Steinmair M, Broinger G, Pallwien-Prettner L, Beheshti M, Imamovic L, Beheshti M, Rendl G, Hackl D, Tsybrovsky O, Steinmair M, Emmanuel K, Moinfar F, Pirich C, Langsteger W, Bytyqi A, Karanikas G, Mayerhöfer M, Koperek O, Niederle B, Hartenbach M, Beyer T, Herrmann K, Czernin J, Rausch I, Rust P, DiFranco MD, Lassen M, Stadlbauer A, Mayerhöfer ME, Hartenbach M, Hacker M, Beyer T, Binzel ... περισσότερα »
ROS1-Rearrangement in Thyroid Cancer.
*<i>ROS1</i>-Rearrangement in Thyroid Cancer.* Thyroid. 2016 Apr 18; Authors: Ritterhouse LL, Wirth LJ, Randolph G, Sadow PM, Ross DS, Liddy W, Lennerz JK Abstract <b>Background</b>: Aberrations involving the <i>ROS1</i> gene have not been reported in thyroid cancer. We present a case of <i>ROS1</i>-associated thyroid cancer with unique and aggressive characteristics. <b>Patient findings</b>: A 24 year-old athlete presented with a 3.5 cm left paramedian upper neck mass. Open biopsy demonstrated a papillary thyroid carcinoma arising in the pyramidal lobe. Additional imaging reveal... περισσότερα »
High-throughput image analysis in the diagnosis of papillary thyroid carcinoma
Background Thyroid cancer is the most common endocrine cancer, and its incidence has been increasing worldwide in the past decades. The increasing demand in medicine for rapid and accurate diagnosis enabled the application of digital imaging analysis in order to increase workflow efficiency and accurate analyses. The present study aimed to automatically differentiate papillary thyroid carcinoma from normal thyroid cells using high-throughput image analysis. Methods Images of cellular specimens were taken with a digital camera and were subsequently analyzed. Other software was us...περισσότερα »
Vanishing thyroid gland tumors: Infarction as consequence of FNA?
Background Fine-needle aspiration (FNA)-induced secondary changes were described in various organs. Complete replacement of tumor by necrosis causes diagnostic and management problems. Methods Seven cases of totally or partially vanished thyroid lesions were identified from the archive of Department of Pathology, Fimlab Laboratories within 5 year period. Histopathological slides were revised in all cases. Results Total thyroidectomy or lobectomy samples were from 4 females and 3 males patients aged 37–83 years (mean 67.1 years). Imaging data were available in 6 cases. Cytology ...περισσότερα »
Inter-observer Variation in the Pathologic Identification of Extranodal Extension in Nodal Metastasis from Papillary Thyroid Carcinoma.
*Inter-observer Variation in the Pathologic Identification of Extranodal Extension in Nodal Metastasis from Papillary Thyroid Carcinoma.* Thyroid. 2016 Apr 18; Authors: Du E, Wenig B, Su HK, Rowe ME, Haser GC, Asa SL, Baloch ZW, Faquin WC, Giordano TJ, Ghossein R, LiVolsi VA, Lloyd RV, Mete O, Ozbek U, Rosai J, Suster S, Thompson LD, Turk A, Urken ML Abstract BACKGROUND: Extranodal extension (ENE) in lymph node metastases has been shown to worsen the prognosis of papillary thyroid cancer (PTC). Despite the clinical significance of ENE, there are no stringent criteria for its micr... περισσότερα »
Cepstral Analysis of Voice in Patients With Thyroidectomy.
*Cepstral Analysis of Voice in Patients With Thyroidectomy.* Clin Exp Otorhinolaryngol. 2016 Apr 19; Authors: Shin YJ, Hong KH Abstract Objectives: The vocal changes after a thyroidectomy are temporary and nonsevere, therefore, obtaining accurate analytical results on the pathological vocal characteristics following such a procedure is difficult. For a more objective acoustic analysis, this study used the cepstral analysis method to examine changes in the patients' voices during the perioperative period regarding sustained vowel phonation. Methods: The sustained phonation of the f... περισσότερα »
Association of TERT Promoter Mutation But Not BRAF Mutation With Increased Mortality in PTC.
Related Articles *Association of TERT Promoter Mutation, But Not BRAF Mutation, With Increased Mortality in PTC.* J Clin Endocrinol Metab. 2015 Dec;100(12):E1550-9 Authors: George JR, Henderson YC, Williams MD, Roberts DB, Hei H, Lai SY, Clayman GL Abstract CONTEXT: Papillary thyroid carcinoma (PTC) carrying the BRAF mutation has been reported to be associated with high recurrence and potentially increased mortality. PTC carrying the TERT promoter mutation has been associated with older age, recurrence, and aggressive disease. OBJECTIVE: The objective of this study was to determi...περισσότερα »
32nd International Austrian Winter Symposium : Zell am See the Netherlands. 20-23 January 2016.
*32nd International Austrian Winter Symposium : Zell am See, the Netherlands. 20-23 January 2016.* EJNMMI Res. 2016 Apr;6(Suppl 1):32 Authors: Langsteger W, Rezaee A, Loidl W, Geinitz HS, Fitz F, Steinmair M, Broinger G, Pallwien-Prettner L, Beheshti M, Imamovic L, Beheshti M, Rendl G, Hackl D, Tsybrovsky O, Steinmair M, Emmanuel K, Moinfar F, Pirich C, Langsteger W, Bytyqi A, Karanikas G, Mayerhöfer M, Koperek O, Niederle B, Hartenbach M, Beyer T, Herrmann K, Czernin J, Rausch I, Rust P, DiFranco MD, Lassen M, Stadlbauer A, Mayerhöfer ME, Hartenbach M, Hacker M, Beyer T, Binzel ... περισσότερα »
Inter-observer Variation in the Pathologic Identification of Extranodal Extension in Nodal Metastasis from Papillary Thyroid Carcinoma.
*Inter-observer Variation in the Pathologic Identification of Extranodal Extension in Nodal Metastasis from Papillary Thyroid Carcinoma.* Thyroid. 2016 Apr 18; Authors: Du E, Wenig B, Su HK, Rowe ME, Haser GC, Asa SL, Baloch ZW, Faquin WC, Giordano TJ, Ghossein R, LiVolsi VA, Lloyd RV, Mete O, Ozbek U, Rosai J, Suster S, Thompson LD, Turk A, Urken ML Abstract BACKGROUND: Extranodal extension (ENE) in lymph node metastases has been shown to worsen the prognosis of papillary thyroid cancer (PTC). Despite the clinical significance of ENE, there are no stringent criteria for its micr... περισσότερα »
MANAGEMENT OF ENDOCRINE DISEASE: ACROMEGALY AND CANCER: AN OLD DEBATE REVISITED.
*MANAGEMENT OF ENDOCRINE DISEASE: ACROMEGALY AND CANCER: AN OLD DEBATE REVISITED.* Eur J Endocrinol. 2016 Apr 18; Authors: Boguszewski CL, Ayuk J Abstract Based on experimental and animal models, epidemiological data from non-acromegaly populations, and longitudinal and cross-sectional cohorts of patients with acromegaly, a potential association between acromegaly and cancer has long been hypothesized, in particular colorectal cancer, and to a lesser extent breast, thyroid, and prostate cancers. The exact mechanisms underlying this potential association have not been fully elucid... περισσότερα »
The role of Inadine in wound care
a consensus document: Abstract Iodine-based products are antibacterial. The small iodine molecular size is ideally suited to treat surface critical colonisation. Inadine is a 10% povidone iodine dressing with the equivalent of 1% available iodine that is easily extracted from the viscose backing by serum or exudate. The use of hydrophilic polyethylene glycol tulle dressing delivery vehicle allows the dressing to be easily removed by irrigation with potable water or saline. In this study, we developed a short online survey completed by 23 wound-care key opinion leaders from the nur... περισσότερα »
Margins of oral leukoplakia
autofluorescence and histopathology.: [image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Elvers D, Braunschweig T, Hilgers RD, Ghassemi A, Möhlhenrich SC, Hölzle F, Gerressen M, Modabber A Abstract Autofluorescence devices are widely used to examine oral lesions. The aim of this study was to see whether there were any signs of dysplasia, parakeratosis, or mucosal inflammation in the borders of homogeneous oral leukoplakia using autofluorescence, and we also compared clinically visible extensions with those detected by autofluorescence. Twenty patients with 26 homogeneous... περισσότερα »
Epidermal Cyst in the Scrotum Successfully Treated while Preserving the Testis: A Case Report
A 66-year-old male was referred to our hospital for further examination of a scrotal mass. Because of the risk of testicular cancer, we first clamped the vessels as a course of higher orchiectomy. Then, we approached the tumor through the scrotum and successfully resected it while preserving the testis. A histopathological diagnosis revealed an epidermal… Continue reading Epidermal Cyst in the Scrotum Successfully Treated while Preserving the Testis: A Case Report
BRAF Mutation (V600E) Prevalence in Mexican Patients Diagnosed with Melanoma
Background: B-Raf is a serine/threonine protein kinase activating the MAP kinase/ERK-signaling pathway. It has been shown that 50% of melanomas harbor activating BRAF mutations, with over 90% being the V600E mutation. Objective: The goal of this research was to determine the prevalence of the BRAF V600E mutation in patients from Central Mexico diagnosed with primary… Continue reading BRAF Mutation (V600E) Prevalence in Mexican Patients Diagnosed with Melanoma
Gastric Schwannoma Mimicking Malignant Gastrointestinal Stromal Tumor Exhibiting Increased Fluorodeoxyglucose Uptake
A schwannoma is a kind of neurogenic tumor that rarely occurs in the gastrointestinal tract. Gastric schwannomas make up 0.2% of all gastric neoplasms. Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors and up to 60-70% of GIST occur in the stomach. Schwannoma and GIST are similar in clinical features, so they are… Continue reading Gastric Schwannoma Mimicking Malignant Gastrointestinal Stromal Tumor Exhibiting Increased Fluorodeoxyglucose Uptake
Deep Brain Stimulation of the Ventroposteromedial (VPM) Thalamus 10 Years after VPM Thalamotomy to Treat a Recurrent Facial Pain
We report the successful treatment of recurrent facial pain by deep brain stimulation (DBS) of the ventroposteromedial thalamic nucleus (VPM-DBS), 10 years after VPM thalamotomy. A 62-year-old woman who suffered from an atypical right-sided trigeminal neuralgia of the V1 and V2 branches was successfully treated a decade ago with a radiofrequency VPM thermocoagulation. Ten years… Continue reading Deep Brain Stimulation of the Ventroposteromedial (VPM) Thalamus 10 Years after VPM Thalamotomy to Treat a Recurrent Facial Pain
Theologische Grundlagen für das Beten von Christen und Muslimen in der Schule. Eine evangelische Sicht
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SsUK2F via IFTTT
Inszenierte Sinnsysteme Gärten als Heterotopien in der europäischen Religionsgeschichte
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/23Jz0rZ via IFTTT
Pityriasis Rosea: A Comprehensive Classification
Pityriasis rosea (PR) is an acute, self-limiting exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7. The disease typically begins with a single, erythematous plaque followed by a secondary eruption with lesions on the cleavage lines of the trunk (configuration of a ‘Christmas tree’). The duration may vary from 2… Continue reading Pityriasis Rosea: A Comprehensive Classification
Renal parenchymal resistance in patients with biopsy proven glomerulonephritis: Correlation with histological findings.
Renal parenchymal resistance in patients with biopsy proven glomerulonephritis: Correlation with histological findings. Int J Immunopathol Pharmacol. 2016 Apr 18; Authors: Gigante A, Barbano B, Di Mario F, Rosato E, Simonelli M, Rocca AR, Conti F, Ceccarelli F, Giannakakis K, Valesini G, Cianci R Abstract Renal Doppler ultrasound is increasingly used in nephrology for the… Continue reading Renal parenchymal resistance in patients with biopsy proven glomerulonephritis: Correlation with histological findings.
Hyperestrogenism and low serum testosterone-17β-estradiol ratio are associated with non-ba cterial male accessory gland inflammation.
Hyperestrogenism and low serum testosterone-17β-estradiol ratio are associated with non-bacterial male accessory gland inflammation. Int J Immunopathol Pharmacol. 2016 Apr 18; Authors: Condorelli RA, Calogero AE, La Vignera S Abstract This study evaluated the serum concentrations of the main sex hormones in selected patients with non-bacterial male accessory gland infection (MAGI). The results suggest that… Continue reading Hyperestrogenism and low serum testosterone-17β-estradiol ratio are associated with non-ba cterial male accessory gland inflammation.
UK charity @Bowel_Cancer_UK warns that ‘lives are being lost’ because of delays in introducing a new screening test: https://t.co/i3hlOLCl7f
UK charity @Bowel_Cancer_UK warns that ‘lives are being lost’ because of delays in introducing a new screening test: https://t.co/i3hlOLCl7f from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/722717467227897856 via IFTTT
The Parkland 12-Minute Checklist Tracheostomy
DOI: http://dx.doi.org/10.1016/j.joms.2015.10.022 - Purpose To validate the surgical time and propose a new checklist or algorithm to execute a tracheotomy within 12 minutes with optimal outcomes. Materials and Methods The authors designed and implemented a checklist method for tracheotomy based on 6 consecutive patients with respiratory failure and prolonged intubation in a medical intensive care unit. The primary outcome variable was surgical time for a tracheotomy performed by a fifth- or sixth-year resident under the supervision of the senior author (M.Z.). Results Six co... περισσότερα »
Hearing performance as a predictor of postural recovery in cochlear implant users.
*Hearing performance as a predictor of postural recovery in cochlear implant users.* Braz J Otorhinolaryngol. 2016 Mar 31; Authors: Greters ME, Bittar RS, Grasel SS, Oiticica J, Bento RF Abstract OBJECTIVE: This study aimed to evaluate if hearing performance is a predictor of postural control in cochlear implant (CI) users at least six months after surgery. METHODS: Cross-sectional study including (CI) recipients with post-lingual deafness and controls who were divided into the following groups: nine CI users with good hearing performance (G+), five CI users with poor hearing per... περισσότερα »
Attenuation of progressive hearing loss in DBA/2J mice by reagents that affect epigenetic modifications is associated with up-regulation of the zinc importer Zip4.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Attenuation of progressive hearing loss in DBA/2J mice by reagents that affect epigenetic modifications is associated with up-regulation of the zinc importer Zip4.* PLoS One. 2015;10(4):e0124301 Authors: Mutai H, Miya F, Fujii M, Tsunoda T, Matsunaga T Abstract Various factors that are important for proper hearing have been identified, including serum levels of zinc. Here we investigated whether epigenetic regulatory pathways, which can be modified by environmental factors, could modula... περισσότερα »
Ibuprofen and etodolac in edema, trismus and pain
Comparative assessment of ibuprofen and etodolac in edema, trismus and pain in lower third molar surgery: A randomized, clinical trial via Oral and Maxillofacial Surgery Publication date: Available online 13 April 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Júlio César Silva de Oliveira, Gustavo Augusto Grossi de Oliveira, Ana Paula Farnezi Bassi PurposeTo compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus following extraction of lower-third molars.MethodsTwenty young adults with two impacted “mandibular-third” mol... περισσότερα »
Management of Inoperable Malignant Neoplasms.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
*Management of Inoperable Malignant Neoplasms.* Adv Otorhinolaryngol. 2016;78:157-167 Authors: Kiess AP, Quon H Abstract For patients with inoperable salivary gland malignancy, radiation therapy has significant limitations but has been the mainstay of treatment. With standard photon radiation (X-rays), the 10-year loco-regional control (LRC) and overall survival rates are only ∼25%. Neutron radiation has potential biological advantages over photon radiation because it causes increased DNA damage, and studies of patients with inoperable salivary gland malignancy have shown improve...περισσότερα »
Expression of a disintegrin and metalloproteinase-33 protein in vocal fold polyps.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
Related Articles *Expression of a disintegrin and metalloproteinase-33 protein in vocal fold polyps.* J Laryngol Otol. 2015 Jul;129(7):688-92 Authors: Akdogan MV, Erinanc H, Topal O, Erbek SS Abstract BACKGROUND: This study aimed to evaluate the association of a disintegrin and metalloproteinase-33 protein ('ADAM-33') expression in vocal polyp formation and to determine its correlation with clinical characteristics. METHODS: Medical charts and histological sections of 32 patients diagnosed with vocal polyps who underwent surgery were analysed. Controls were histopathologically no...περισσότερα »
Linear Epidermal Nevus
: A Case Report With Oral and Facial Manifestations via Oral and Maxillofacial Surgery Publication date: Available online 13 April 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Christopher Maly, Heather Olmo, Steven Stokes, Hank Cole A 20 year old male presented to the Oral and Maxillofacial Surgery Department for evaluation and treatment of his dentiofacial deformity. Upon examination, it was noted that he had marked hemi-facial hyperpigmented papillomatous lesions covering the upper and middle thirds of right-side of his face extending to the right upper lid. Of n... περισσότερα »
Is Early Nasal Shaping With a Limited Alar Base Incision Possible in the Repair of Cleft Lips?.
Is Early Nasal Shaping With a Limited Alar Base Incision Possible in the Repair of Cleft Lips?.: The repair of cleft lips has an important place in plastic and reconstructive surgery. In the treatment of these deformities, the aim was to restore the normal lip morphology in the cleft area as well as repairing any coexisting nasal deformities. Various methods are in use for this purpose. One of the most commonly employed surgical methods is Millard repair. However, this method may lead to additional scarring in the alar base on the cleft side subsequent to the incision. In this study,... περισσότερα »
Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3
*Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3* Emerging Microbes & Infections 5, e39 (April 2016). doi:10.1038/emi.2016.33 Authors: Pak-Yin Lui, Lok-Yin Roy Wong, Cheuk-Lai Fung, Kam-Leung Siu, Man-Lung Yeung, Kit-San Yuen, Chi-Ping Chan, Patrick Chiu-Yat Woo, Kwok-Yung Yuen & Dong-Yan Jin from Infection via ola Kala on Inoreader http://ift.tt/1Sk8Wc8 via IFTTT
MRI Evidence of Varicella Zoster Virus Polyneuropathy
Involvement of the Glossopharyngeal and Vagus Nerves Associated With Ramsay Hunt Syndrome.: The involvement of lower cranial nerve palsies is less frequent in Ramsay Hunt syndrome caused by varicella zoster virus (VZV). The authors report 1 of extremely rare patients of radiologically proven polyneuropathy of VZV infection with magnetic resonance imaging findings of VII, IX, and X cranial nerve involvement is a 62-year-old female patient, who initially presented with Ramsay Hunt syndrome. Varicella zoster virus infection should be considered even in patients who show unilateral pal... περισσότερα »
Suturectomy in Trigonocephaly and Anterior Plagiocephaly.
Long-Term Assessment of Introduction: Techniques for treating trigonocephaly and anterior plagiocephaly have evolved from the initial suturectomy technique to frontal cranioplasty. The authors evaluated the suturectomy technique in adolescent patients with these craniosynostoses, by carrying out a retrospective, long-term assessment at the end of growth. Methods: Patients with anterior plagiocephaly or trigonocephaly were included. All had undergone coronal or metopic suturectomy with bilateral orbitofrontal bandeau resection between 1997 and 2005. The primary endpoint was the W... περισσότερα »
Skullbase Tumor.: Modified Facial Translocation Approach
in a One-Month Old With a Skullbase Tumor.: The authors present a patient of a neonate with a skull base extragonadal germ cell tumor requiring a modified facial translocation approach for resection. A 1-week-old female presented with right proptosis, eyelid edema, and nasal obstruction. Imaging revealed a 3-cm right-sided skull base mass involving the right maxillary, ethmoid, sphenoid sinuses, orbit, infratemporal fossa, and cavernous sinus via skull base erosion. The lesion was refractory to chemotherapy and required surgical excision. A modified facial translocation approach wi... περισσότερα »
Multiple Peripheral Osteomas
Related to Frontal Exposure by Bicoronal Incision.: Osteoma of the skull is a benign slow-growing osteogenic lesion typically composed of well-differentiated mature bone tissue. It is characterized by the proliferation of compact or cancellous bone and is found almost exclusively in the head and neck region. Central, peripheral, and extraskeletal are the major variants of craniofacial osteomas. Trauma, inflammation, developmental disorders, and genetic defects are considered their etiologic factors. Paranasal sinuses, especially frontal and ethmoidal sinuses, are the favorite locat... περισσότερα »
Cellular Alterations in Fat Cells Harvested With Laser-Assisted Liposuction and Suction-Assisted Liposuction.
Comparison of Objective: The aim of the present study was to evaluate the viability and proliferative capacity of adipose-derived stem cells obtained by laser-assisted liposuction (LAL). Methods: Fat tissue was obtained from 7 male patients treated surgically for gynecomastia. On one side, harvesting was made before LAL, while it was implemented after LAL on the contralateral side. Viability, cell surface antigens, pluripotency, and apoptosis were assessed and compared in these samples. Results: Cells harvested before and after LAL did not exhibit any significant difference in t... περισσότερα »
Condyle Bone Defects
Effect of Field of View on Detection of Condyle Bone Defects Using Cone Beam Computed Tomography.: In maxillofacial imaging, cone beam computed tomography (CBCT) is currently the modality of choice for assessment of bony structures of the temporomandibular joint (TMJ). Factors affecting the quality of CBCT images can change its diagnostic accuracy. This study aimed to assess the effect of field of view (FOV) and defect size on the accuracy of CBCT scans for detection of bone defects of the TMJs. This study was conducted on 12 sound TMJs of 6 human dry skulls. Erosions and osteophytes...περισσότερα »
Primary Spinal Oligoastrocytoma.
Primary Spinal Oligoastrocytoma.: Astrocytomas are the most common intramedullary spinal cord tumors in pediatric and adolescent patients and the incidence decreases with age. Spinal oligoastrocytoma, which is a mixed glioma with distinct astrocytic and oligodendroglial components, is an extremely rare pathology of the spinal cord. To authors' best of knowledge, there are only 7 spinal oligoastrocytomas reported in the English literature. Here, the authors report a patient of a pathologically confirmed spinal oligoastrocytoma, who presented with severe left leg pain and numbness. Th...περισσότερα »
Microgap With Three-Dimensional X-Ray Microtomography
Evaluation of Microgap With Three-Dimensional X-Ray Microtomography: Internal Hexagon Versus Cone Morse.: Background: Microgap is defined as the microscopic space that exists between the implant body and abutment. The main mechanism proposed for microgap-related crestal bone loss is the role of this space as a trap for bacteria and thus, as a putative etiological factor for inflammatory reaction in the peri-implant soft tissues. The aim of this paper was to evaluate, with X-ray 3D microtomography, the microscopic space that exists between the implant body and abutment with internal ...περισσότερα »
The Usefulness of Three-Dimensional Reconstruction Computed Tomography in the Nasal Dermoid Cyst.
The Usefulness of Three-Dimensional Reconstruction Computed Tomography in the Nasal Dermoid Cyst.:
Botulinum Toxin Type A as Preoperative Treatment for Immediately Loaded Dental Implants Placed in Fresh Extraction Sockets for Full-Arch Restoration of Patients With Bruxism.
Botulinum Toxin Type A as Preoperative Treatment for Immediately Loaded Dental Implants Placed in Fresh Extraction Sockets for Full-Arch Restoration of Patients With Bruxism.: Objectives: The aim of the present report was to describe the use of Botulinum toxin type A as preoperative treatment for immediately loaded dental implants placed in fresh extraction sockets for full-arch restoration of patients with bruxism. Methods: Patients with bruxism who were scheduled to receive immediately loaded full-arch implant supported fixed restorations were included in this retrospective clinic... περισσότερα »
Three-Dimensional Hydroxyapatite/Beta-Tricalcium Phosphate Scaffold.
Human Adipose-Derived Stem Cells on Rapid Prototyped In the study, we assess a rapid prototyped scaffold composed of 30/70 hydroxyapatite (HA) and beta-tricalcium-phosphate ([beta]-TCP) loaded with human adipose-derived stem cells (hASCs) to determine cell proliferation, differentiation toward osteogenic lineage, adhesion and penetration on/into the scaffold. In this in vitro study, hASCs isolated from fat tissue discarded after plastic surgery were expanded, characterized, and then loaded onto the scaffold. Cells were tested for: viability assay (Alamar Blue at days 3, 7 and Li... περισσότερα »
Medication-Related Osteonecrosis of the Jaw
Around Dental Implants: Implant Surgery-Triggered or Implant Presence-Triggered Osteonecrosis?.: Introduction: Dentoalveolar surgery including tooth extractions and dental implants placement is considered the major risk factor for developing medication-related osteonecrosis of the jaw (MRONJ). In this study, a patient series of MRONJ around dental implants were carefully analyzed to describe the findings and to assess the possible risk factors. Methods: Fifteen patients with peri-implant bone osteonecrosis were selected out of a group of 250 patients (6%). Patients were divided in...περισσότερα »
Bone Regeneration Between Bone Morphogenetic Protein-2 and Platelet-Derived Growth Factor-BB
Histologic and Histomorphometric Comparison of Bone Regeneration Between Bone Morphogenetic Protein-2 and Platelet-Derived Growth Factor-BB in Experimental Groups.: Efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) and recombinant human platelet-derived growth factor-BB (rhPDGF-BB) delivered via absorbable collagen sponge (ACS) on bone formation was evaluated in guinea pig tibias. Three-millimeter-circular bone tibia defects were created in 24 guinea pigs assigned randomly to 4 groups according to the following defect filling materials: ACS only, rhBMP-2+ACS, rhPD...περισσότερα »
Mandibular Reconstruction Using Custom-Made Titanium Mesh Tray and Autogenous Particulate Cancellous Bone and Marrow Harvested From Tibia and/or Ilia.
Clinical Usefulness of The objective of this study was to evaluate usefulness of mandibular reconstructions using custom-made titanium mesh (Ti-mesh) tray and particulate cancellous bone and marrow (PCBM). Consecutive 21 patients who underwent mandibular reconstruction were enrolled in this study. They were 13 men and 8 women (mean age, 52.0 years). Virtual reality simulation was performed using computer software based on the preoperative computed tomography data. A 3-dimensional skull model was constructed using 3-dimensional printer. A tray was custom-made from Ti-mesh sheet be...περισσότερα »
HPV and Oropharyngeal Cancer Mystery
A glimmer of hope!: Abstract Viral associated cancer brings to forth the intricate relationships between viruses and host innate immunity and genetic susceptibility1. This interplay is particularly germane to viral associated nasopharyngeal and oropharyngeal squamous carcinomas, where lymphoid rich submucosa characterizes these sites. The inability of the existing immune defenses to neutralize EBV and HPV (both are dsDNA viruses) is currently unknown. This is largely due to the lack of direct cause/effect, the ubiquitous presence of these viruses and the unique demographic and epi... περισσότερα »
Providing allergen immunotherapy in the office.
Safety considerations in Purpose of review: This review highlights the risks of allergy immunotherapy, methods to improve the quality and safety of allergy treatment, the current status of allergy quality metrics, and the future of quality measurement. In the current healthcare environment, the emphasis on outcomes measurement is increasing, and providers must be better equipped in the development, measurement, and reporting of safety and quality measures. Recent findings: Immunotherapy offers the only potential cure for allergic disease and asthma. Although well tolerated and e... περισσότερα »
Stability of allergen extracts to establish expiration dating.
Update: Purpose of review: The article reviews studies pertaining to US manufactured allergen extract stability that contribute to guidance for expiration dating for bulk concentrates, diluted patient testing and treatment vials, and adjustments following elevated temperature excursions. Recent findings: Studies on allergen stability were completed to satisfy the Food and Drug Administration requirements supporting labeled expiration dating for standardized short ragweed, dust mites, cat, grass, and venom extracts and are not published. These studies demonstrated the stability e...περισσότερα »
Vocal fold paresis: a review of clinical presentation, differential diagnosis, and prognostic indicators.
Vocal fold paresis: a review of clinical presentation, differential diagnosis, and prognostic indicators.: Purpose of review: Vocal fold paresis is a complex, controversial, and unique clinical entity. Guidance in assessing and evaluating these patients is provided in this comprehensive review of the current literature discussing the varying clinical presentation, the broad differential and general prognosis. Recent findings: Patients with vocal fold paresis can present with elements of hyperfunction, which can often mask an underlying paresis. As such, repetitive phonatory tasks an... περισσότερα »
Extracranial internal carotid artery pseudoaneurysm
Clinical RecordExtracranial internal carotid artery pseudoaneurysm in a two-year-old child: case reportM Roosa1 c1 and I Butlera1 a1 Department of Otorhinolaryngology, University of the Free State, Bloemfontein, South Africa Abstract Background: Extracranial internal carotid artery pseudoaneurysm is very rare in children. Method: This paper discusses the case of a boy, aged two years and six months, who presented with an enlarging neck mass and unilateral bloody otorrhoea. Special investigations revealed an extracranial internal carotid artery pseudoaneurysm. Results: The patient made...περισσότερα »
Fistula and stricture among anterolateral thigh, radial forearm, and jejunal free tissue transfers in circumferential pharyngo-esophageal reconstruction.
An objective comparison regarding rate of [image: http:--media.wiley.com-assets-7315-19-Wi] Authors: Tan NC, Lin PY, Kuo PJ, Tsai YT, Chen YC, Nguyen KT, Kuo YR Abstract BACKGROUND: The three commonly used free flaps for circumferential pharyngeal reconstruction after total pharyngo-laryngectomy are the radial forearm flap (RFF), the anterolateral thigh (ALT) flap, and the jejunum flap. This study was to objectively compare three different flaps for pharyngeal reconstruction during the past 10 years. Stricture and fistula were assessed using esophagogram and esophagoscopy. METHODS... περισσότερα »
Chimeric Anterolateral Thigh Flap for Total Thoracic Esophageal Reconstruction.
Chimeric Anterolateral Thigh Flap for Total Thoracic Esophageal Reconstruction.: [image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Ruiz-Moya A, Segura-Sampedro JJ, Sicilia-Castro D, Carvajo-Pérez F, Gómez-Cía T, Vázquez-Medina A, Ibáñez-Delgado F Abstract Gastric pull-up is generally the first choice for a total thoracic esophageal reconstruction. Malfunction of this gastric conduit is uncommon, but devastating when it occurs: it causes marked comorbidity to the patient, preventing oral intake and worsening quality of life. Secondary salvage thoracic esophageal reconstr... περισσότερα »
The role of chemerin and ChemR23 in stimulating the invasion of squamous oesophageal cancer cells.
The role of chemerin and ChemR23 in stimulating the invasion of squamous oesophageal cancer cells Br J Cancer. 2016 Apr 19; Authors: Kumar JD, Kandola S, Tiszlavicz L, Reisz Z, Dockray GJ, Varro A Abstract BACKGROUND: Stromal cells, including cancer-associated myofibroblasts (CAMs), are recognised to be determinants of cancer progression, but the mechanisms remain uncertain. The chemokine-like protein, chemerin, is upregulated in oesophageal squamous cancer (OSC) CAMs compared with adjacent tissue myofibroblasts (ATMs). In this study, we hypothesised that chemerin stimulates OSC c... περισσότερα »
Cell Recruiting Chemokine-Loaded Sprayable Gelatin Hydrogel Dressings
for Diabetic Wound Healing via Acta Biomaterialia Publication date: Available online 19 April 2016 *Source:*Acta Biomaterialia Author(s): Dong Suk Yoon, Yunki Lee, Hyun Aae Ryu, Yeonsue Jang, Kyoung-Mi Lee, Yoorim Choi, Woo Jin Choi, Moses Lee, Kyung Min Park, Ki Dong Park, Jin Woo Lee In this study, we developed horseradish peroxidase (HRP)-catalyzed sprayable gelatin hydrogels (GH) as a bioactive wound dressing that can deliver cell-attracting chemotactic cytokines to the injured tissues for diabetic wound healing. We hypothesized that topical administration of chemokines using GH ... περισσότερα »
Cancer Stem Cell Research
An Alginate-based Platform for via Acta Biomaterialia Publication date: Available online 19 April 2016 *Source:*Acta Biomaterialia Author(s): Shu-pei Qiao, Yu-fang Zhao, Chun-feng Li, Yan-bin Yin, Qing-yuan Meng, Feng-Huei Lin, Yi Liu, Xiao-lu Hou, Kai Guo, Xiong-biao Chen, Wei-ming Tian As the primary determinants of the clinical behaviors of human cancers, the discovery of cancer stem cells (CSCs) represents an ideal target for novel anti-cancer therapies [1]. Notably, CSCs are difficult to propagate in vitro, which severely restricts the study of CSC biology and the development of... περισσότερα »
Antimicrobial LL37-Modified Collagen-Hyaluronic Acid Detachable Multilayers
The Design of via Acta Biomaterialia Publication date: Available online 19 April 2016 *Source:*Acta Biomaterialia Author(s): Margaret E. Cassin, Andrew J. Ford, Sophia M. Orbach, Scott E. Saverot, Padmavathy Rajagopalan The design of antimicrobial membranes and thin films are critical for the design of biomaterials that can combat bacterial contamination. Since the long-term use of conventional antibiotics can result in bacterial resistance, there is a critical need to incorporate natural antimicrobial peptides (AMPs) that not only prevent a wide range of pathogens from causing infec... περισσότερα »
Enhanced anti-angiogenic and anti-glioma therapy
Paclitaxel-loaded solid lipid nanoparticles modified with Tyr-3-octreotide for via Acta Biomaterialia Publication date: Available online 19 April 2016 *Source:*Acta Biomaterialia Author(s): Indranil Banerjee, Kakali De, Dibyanti Mukherjee, Goutam Dey, Sankha Chattopadhyay, Manabendra Mukherjee, Mahitosh Mandal, Amal Kumar Bandyopadhyay, Amit Gupta, Santanu Ganguly, Mridula Misra Somatostatin receptors (SSTRs) especially subtype 2 (SSTR2) are overexpressed in glioma. By taking advantage of the specific expression of SSTR2 on both glioma neovasculature endothelial cells and glioma cells...περισσότερα »
Induction chemotherapy followed by up-front autologous stem cell transplantation may have a survival benefit in high-risk diffuse large B-cell lymphoma patients.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Induction chemotherapy followed by up-front autologous stem cell transplantation may have a survival benefit in high-risk diffuse large B-cell lymphoma patients.* Exp Hematol. 2016 Jan;44(1):3-13 Authors: Shin HJ, Yoon DH, Lee HS, Oh SY, Yang DH, Kang HJ, Chong SY, Park Y, Do Y, Lim SN, Jo JC, Lee WS, Chung JS, Consortium for Improving Survival of Lymphoma Abstract We compared the outcomes of patients with higher-risk diffuse large B-cell lymphoma (DLBCL) who were treated with either up-front autologous stem cell... περισσότερα »
Sensitivity of chronic lymphocytic leukemia cells to small targeted therapeutic molecules: An in vitro comparative study.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Sensitivity of chronic lymphocytic leukemia cells to small targeted therapeutic molecules: An in vitro comparative study.* Exp Hematol. 2016 Jan;44(1):38-49.e1 Authors: Sylvan SE, Skribek H, Norin S, Muhari O, Österborg A, Szekely L Abstract New drugs targeting important cellular signaling pathways are currently being developed for chronic lymphocytic leukemia (CLL). It is therefore of interest to analyze their in vitro killing capacity in manufacturer-independent, comparative experiments. We here report on the s... περισσότερα »
Advances in the Treatment of Secondary CNS Lymphoma.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Advances in the Treatment of Secondary CNS Lymphoma.* J Clin Oncol. 2015 Nov 20;33(33):3851-3 Authors: Schmitz N, Wu HS PMID: 26282665 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SaqqLt via IFTTT
Muscular hypertrophy and atrophy in normal rats provoked by the administration of normal and denervated muscle extracts.
*Muscular hypertrophy and atrophy in normal rats provoked by the administration of normal and denervated muscle extracts.* Histol Histopathol. 2016 Apr 19;:11776 Authors: Agüera E, Castilla S, Luque E, Jimena I, Leiva-Cepas F, Ruz-Caracuel I, Peña J Abstract This study was conducted to determine the effects of extracts obtained from both normal and denervated muscles on different muscle types. Wistar rats were used and were divided into a control group and four experimental groups. Each experimental group was treated intraperitoneally during 10 consecutive days with a different e...περισσότερα »
Angiogenesis inhibitor; 16 new citations
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *Angiogenesis inhibitor* These pubmed results were generated on 2016/04/20 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1rj68Wt via IFTTT
[A case-series study on clinical presentation neuroradiological characteristics and outcome of 56 consecutive patients suspected of having spontaneous intracranial hypotension].
[image: http:--linkout.jstage.jst.go.jp-logo_non] Related Articles *[A case-series study on clinical presentation, neuroradiological characteristics, and outcome of 56 consecutive patients suspected of having spontaneous intracranial hypotension].* Rinsho Shinkeigaku. 2015;55(9):623-9 Authors: Arai M Abstract The author reviewed the clinical records and neuroradiologic examinations of 86 consecutive patients with orthostatic headache who visited our clinic between April 1995 and December 2014. Fifty-six patients were suspected to have spontaneous intracranial hypotension (SIH). T... περισσότερα »
MRI-based methods for quantification of the cerebral metabolic rate of oxygen.
*MRI-based methods for quantification of the cerebral metabolic rate of oxygen.* J Cereb Blood Flow Metab. 2016 Apr 18; Authors: Rodgers ZB, Detre JA, Wehrli FW Abstract The brain depends almost entirely on oxidative metabolism to meet its significant energy requirements. As such, the cerebral metabolic rate of oxygen (CMRO2) represents a key measure of brain function. Quantification of CMRO2has helped elucidate brain functional physiology and holds potential as a clinical tool for evaluating neurological disorders including stroke, brain tumors, Alzheimer's disease, and obstruct... περισσότερα »
Efficacy of combined gemcitabine oxaliplatin and pegaspargase (P-gemox regimen) in patients with newly diagnosed advancedstage or relapsed/refractory extranodal NK/T-cell lymphoma.
*Efficacy of combined gemcitabine, oxaliplatin and pegaspargase (P-gemox regimen) in patients with newly diagnosed advancedstage or relapsed/refractory extranodal NK/T-cell lymphoma.* Oncotarget. 2016 Apr 8; Authors: Wang JH, Wang L, Liu CC, Xia ZJ, Huang HQ, Lin TY, Jiang WQ, Lu Y Abstract Extranodal natural killer/T-cell lymphoma (ENKTL) is an aggressive neoplasm with a poor outcome. Asparaginase-based regimens are recommended for patients with advanced-stage or relapsed/refractory ENKTL. We retrospectively investigated the efficacy and toxicity of combined gemcitabine, oxalipl... περισσότερα »
Targeting estrogen/estrogen receptor alpha will enhance Bacillus Calmette-Guerin efficacy in bladder cancer.
*Targeting estrogen/estrogen receptor alpha will enhance Bacillus Calmette-Guerin efficacy in bladder cancer.* Oncotarget. 2016 Apr 15; Authors: Shang Z, Li Y, Hsu I, Zhang M, Tian J, Wen S, Han R, Messing EM, Chang C, Niu Y, Yeh S Abstract Recent studies showed the potential linkage of estrogen/estrogen receptor signaling with bladder tumorigenesis, yet detailed mechanisms remain elusive. Here we found a new potential therapy with the combination of Bacillus Calmette Guerin (BCG) and the anti-estrogen ICI 182,780 led to better suppression of bladder cancer (BCa) than BCG alone. ... περισσότερα »
Clinical and genetic features of lung squamous cell cancer in never-smokers.
*Clinical and genetic features of lung squamous cell cancer in never-smokers.* Oncotarget. 2016 Apr 15; Authors: Huang Y, Wang R, Pan Y, Zhang Y, Li H, Cheng C, Zheng D, Zheng S, Li Y, Shen X, Hu H, Cai D, Wang S, Zhang Y, Xiang J, Sun Y, Zhang J, Chen H Abstract To evaluate the importance of specific driver mutations to the development and outcome of lung squamous cell cancer (SQCC) in never-smokers, we assessed the clinicopathological characteristics and outcomes of 597 patients who underwent complete resection of SQCCs. In total, 88 (14.7%) never-smokers and 509 (85.3%) ever-s...περισσότερα »
MUC1 stimulates EGFR expression and function in endometrial cancer.
*MUC1 stimulates EGFR expression and function in endometrial cancer.* Oncotarget. 2016 Apr 15; Authors: Engel BJ, Bowser JL, Broaddus RR, Carson DD Abstract The current standard of care for endometrial cancer patients involves hysterectomy with adjuvant radiation and chemotherapy, with no effective treatment for advanced and metastatic disease. MUC1 is a large, heavily glycosylated transmembrane protein that lubricates and protects cell surfaces and increases cellular signaling through the epidermal growth factor receptor (EGFR). We show for the first time that MUC1 stimulates EG... περισσότερα »
Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells.
*Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells.* Oncotarget. 2016 Apr 15; Authors: Pallis M, Burrows F, Ryan J, Grundy M, Seedhouse C, Abdul-Aziz A, Montero J, Letai A, Russell N Abstract Direct co-operation between sensitiser molecules BAD and NOXA in mediating apoptosis suggests that therapeutic agents which sensitise to BAD may complement agents which sensitise to NOXA. Dynamic BH3 profiling is a novel methodology that we have applied to the measurement of complemen...περισσότερα »
EZH2-mediated repression of GSK-3β and TP53 promotes Wnt/β-catenin signaling-dependent cell expansion in cervical carcinoma.
*EZH2-mediated repression of GSK-3β and TP53 promotes Wnt/β-catenin signaling-dependent cell expansion in cervical carcinoma.* Oncotarget. 2016 Apr 15; Authors: Chen Q, Zheng PS, Yang WT Abstract Enhancer of zeste homolog 2 (EZH2), a catalytic core component of the Polycomb repressive complex 2 (PRC2), stimulates the silencing of target genes through histone H3 lysine 27 trimethylation (H3K27me3). Recent findings have indicated EZH2 is involved in the development and progression of various human cancers. However, the exact mechanism of EZH2 in the promotion of cervical cancer is ...περισσότερα »
HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer.
*HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer.* Oncotarget. 2016 Apr 15; Authors: He J, Shen S, Lu W, Zhou Y, Hou Y, Zhang Y, Jiang Y, Liu H, Shao Y Abstract The identification of prognostic markers for gallbladder cancer is needed for clinical practice. Histone deacetylases (HDACs) play an important role in tumor development and progression by modifying histone and non-histone proteins. However, the expression of HDAC1 in patients with gallbladder cancer is still unknown. Here, we reported that HDAC1 expression was elev... περισσότερα »
QKI5-mediated alternative splicing of the histone variant macroH2A1 regulates gastric carcinogenesis.
*QKI5-mediated alternative splicing of the histone variant macroH2A1 regulates gastric carcinogenesis.* Oncotarget. 2016 Apr 15; Authors: Li F, Yi P, Pi J, Li L, Hui J, Wang F, Liang A, Yu J Abstract Alternative pre-mRNA splicing is a key mechanism for increasing proteomic diversity and modulating gene expression. Emerging evidence indicated that the splicing program is frequently dysregulated during tumorigenesis. Cancer cells produce protein isoforms that can promote growth and survival. The RNA-binding protein QKI5 is a critical regulator of alternative splicing in expanding l... περισσότερα »
Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.
*Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.* Oncotarget. 2016 Apr 15; Authors: Xie H, Zhu Y, An H, Wang H, Zhu Y, Fu H, Wang Z, Fu Q, Xu J, Ye D Abstract B4GALT1 is one of seven beta-1, 4-galactosyltransferase (B4GALT) genes, which has distinct functions in various malignances. Here, we evaluate the association of B4GALT1 expression with oncologic outcome in patients with non-metastatic clear cell renal cell carcinoma (ccRCC). A retrospective analysis of 438 patients with non-metastatic ccRCC at two... περισσότερα »
Musashi2 promotes the development and progression of pancreatic cancer by down-regulating Numb protein.
*Musashi2 promotes the development and progression of pancreatic cancer by down-regulating Numb protein.* Oncotarget. 2016 Apr 15; Authors: Sheng W, Dong M, Chen C, Li Y, Liu Q, Dong Q Abstract Musashi2-Numb interaction plays a vital role in the progression of myeloid leukemia. However, its potential role in solid cancers has rarely been reported. We investigated the coordinate function of Musashi2-Numb in the development of pancreatic cancer (PC) in vitro and vivo. Both Musashi2 protein and mRNA levels were higher in PC tissues than that in paired normal pancreas (P<0.05). Musas...περισσότερα »
Inhibition of c-FLIPL expression by miRNA-708 increases the sensitivity of renal cancer cells to anti-cancer drugs.
*Inhibition of c-FLIPL expression by miRNA-708 increases the sensitivity of renal cancer cells to anti-cancer drugs.* Oncotarget. 2016 Feb 3; Authors: Kim EA, Kim SW, Nam J, Sung EG, Song IH, Kim JY, Kwon TK, Lee TJ Abstract Dysregulation of the anti-apoptotic protein, cellular FLICE-like inhibitory protein (c-FLIP), has been associated with tumorigenesis and chemoresistance in various human cancers. Therefore, c-FLIP is an excellent target for therapeutic intervention. MicroRNAs (miRNAs) are small non-coding RNAs that are involved in tumorigenesis, tumor suppression, and resista... περισσότερα »
The Role of Transient Target Stimuli in a Steady-State Somatosensory Evoked Potential-Based Brain-Computer Interface Setup.
*The Role of Transient Target Stimuli in a Steady-State Somatosensory Evoked Potential-Based Brain-Computer Interface Setup.* Front Neurosci. 2016;10:152 Authors: Pokorny C, Breitwieser C, Müller-Putz GR Abstract In earlier literature, so-called twitches were used to support a user in a steady-state somatosensory evoked potential (SSSEP) based brain-computer interface (BCI) to focus attention on the requested targets. Within this work, we investigate the impact of these transient target stimuli on SSSEPs in a real-life BCI setup. A hybrid BCI was designed which combines SSSEPs an...περισσότερα »
The Role of Astrocytes in the Generation Migration and Integration of New Neurons in the Adult Olfactory Bulb.
*The Role of Astrocytes in the Generation, Migration, and Integration of New Neurons in the Adult Olfactory Bulb.* Front Neurosci. 2016;10:149 Authors: Gengatharan A, Bammann RR, Saghatelyan A Abstract In mammals, new neurons in the adult olfactory bulb originate from a pool of neural stem cells in the subventricular zone of the lateral ventricles. Adult-born cells play an important role in odor information processing by adjusting the neuronal network to changing environmental conditions. Olfactory bulb neurogenesis is supported by several non-neuronal cells. In this review, we f... περισσότερα »
Eggshell
The Fracture Toughness of Eggshell via Acta Biomaterialia Publication date: Available online 19 April 2016 *Source:*Acta Biomaterialia Author(s): David Taylor, Megan Walsh, Alexandra Cullen, Peter O’Reilly The shells of avian eggs are very brittle, but how brittle? Fracture toughness, Kc is a standard measure used widely to characterise engineering materials. We devised a novel way to measure Kc and applied it to commercial hens’ eggs, obtaining a value of 0.3 MPa√m. This value is much lower than previous published values, which we argue are incorrect and misleading. We discuss how thi... περισσότερα »
The Subharmonic Mucosal Wave in Excised Larynges via Digital Kymography
Quantifying via Voice Publication date: Available online 19 April 2016 *Source:*Journal of Voice Author(s): Yu Zhang, Nanmu Huang, William Calawerts, Lin Li, Allison L. Maytag, Jack J. Jiang ObjectivesIn this paper, a nonlinear least squares fitting method was proposed to quantify subharmonic mucosal waves.Study Design and MethodsSubharmonic mucosal waves from 10 excised canine larynges were recorded using digital kymography and analyzed using nonlinear least squares and linear least squares methods. Amplitudes of fundamental and subharmonic mucosal wave components of right-upper, ri...περισσότερα »
Voice Pathology Detection and Classification
An Investigation of Multidimensional Voice Program Parameters in Three Different Databases for via Voice Publication date: Available online 19 April 2016 *Source:*Journal of Voice Author(s): Ahmed Al-nasheri, Ghulam Muhammad, Mansour Alsulaiman, Zulfiqar Ali, Tamer A. Mesallam, Mohamed Farahat, Khalid H. Malki, Mohamed A. Bencherif Background and ObjectiveAutomatic voice-pathology detection and classification systems may help clinicians to detect the existence of any voice pathologies and the type of pathology from which patients suffer in the early stages. The main aim of this paper...περισσότερα »
The Perception of Auditory Motion
The Perception of Auditory Motion: The growing availability of efficient and relatively inexpensive virtual auditory display technology has provided new research platforms to explore the perception of auditory motion. At the same time, deployment of these technologies in command and control as well as in entertainment roles is generating an increasing need to better understand the complex processes underlying auditory motion perception. This is a particularly challenging processing feat because it involves the rapid deconvolution of the relative change in the locations of sound sou... περισσότερα »
Cochlear Implant Rate Pitch and Melody Perception as a Function of Place and Number of Electrodes
Cochlear Implant Rate Pitch and Melody Perception as a Function of Place and Number of Electrodes: Six Nucleus cochlear implant recipients participated in a study investigating the effect of place of stimulation on melody perception using rate-pitch cues. Each stimulus was a pulse train delivered on either a single electrode or multiple electrodes sequentially. Four spatial stimulation patterns were used: a single apical electrode, a single mid electrode, a pair of electrodes (apical and mid), and 11 electrodes (from apical to mid). Within one block of trials, all stimuli had the s... περισσότερα »
Comparison of Audiological Results Between a Transcutaneous and a Percutaneous Bone Conduction Instrument in Conductive Hearing Loss.
Comparison of Audiological Results Between a Transcutaneous and a Percutaneous Bone Conduction Instrument in Conductive Hearing Loss.: Objectives: In conductive, mixed hearing losses and single-sided-deafness bone-anchored hearing aids are a well-established treatment. The transcutaneous transmission across the intact skin avoids the percutaneous abutment of a bone-anchored device with the usual risk of infections and requires less care. In this study, the audiological results of the Bonebridge transcutaneous bone conduction implant (MED-EL) are compared to the generally used percu... περισσότερα »
The Association of External and Middle Ear Anomaly and Mandibular Morphology in Congenital Microtia.
The Association of External and Middle Ear Anomaly and Mandibular Morphology in Congenital Microtia.: Objective: To investigate the relationship between the severity of ear anomaly and mandibular dysplasia in congenital microtia. Study Design: Retrospective case review. Setting: Sapporo Medical University Hospital. Patients: Congenital microtia: 44 patients over a period of 4 years. Interventions: The height of the condylar process of the mandible was assessed by three-dimensional computed tomography (CT), and the patients were divided into three groups based on the ratio of the co...περισσότερα »
Test-retest and Interrater Reliability of the Video Head Impulse Test in the Pediatric Population.
Test-retest and Interrater Reliability of the Video Head Impulse Test in the Pediatric Population.: Objective: Determine reliability of horizontal and vertical video head impulse test (vHIT) and effect of maturation on angular vestibular ocular reflex (AVOR) gain estimations and peak head velocities of individual canals in typically developing children and adolescents. Design: Reliability study. Setting: University research laboratory Subjects: Two normal adults mean age 51.5 +/- 0.5 years and 28 typically developing children and adolescents mean age 10 +/- 3.5 years (range, 4.33-... περισσότερα »
CT Scan Imaging of the Human Fetal Labyrinth: Case Series Data Throughout Gestation.
CT Scan Imaging of the Human Fetal Labyrinth: Case Series Data Throughout Gestation.: Objectives: The inner ear in humans reaches its final configuration and its adult size during fetal life. According to the literature, this occurs between 18 and 25 weeks of amenorrhea (WA). Our goal is to clarify the course of inner ear size development. Methods: Using computed tomography (CT) scanner, we studied 13 measurements in the inner ear of a collection of 153 fetuses from 21 to 40 WA. Results: We found no side-related differences or sexual dimorphism in the measurements. Cochlear and vest...περισσότερα »
Secondary Endolymphatic Hydrops After Acoustic Trauma.
Secondary Endolymphatic Hydrops After Acoustic Trauma.: Objective: This study applied an inner ear test battery in patients with secondary hydrops after acoustic trauma to assess the inner ear deficits. Study Design: Retrospective study. Setting: University hospital. Methods: Twenty patients with secondary hydrops after acoustic trauma were assigned to Group A. The interval between noise exposure and the testing time varied from 1 month to 3 years (median 3 months). Another 20 patients without progressive hearing loss for at least 3 years after acoustic trauma were assigned to Grou...περισσότερα »
Impact of Noise Reduction Algorithm in Cochlear Implant Processing on Music Enjoyment.
Impact of Noise Reduction Algorithm in Cochlear Implant Processing on Music Enjoyment.: Objective: Noise reduction algorithm (NRA) in speech processing strategy has positive impact on speech perception among cochlear implant (CI) listeners. We sought to evaluate the effect of NRA on music enjoyment. Study Design: Prospective analysis of music enjoyment. Setting: Academic medical center. Patients: Normal-hearing (NH) adults (N = 16) and CI listeners (N = 9). Intervention: Subjective rating of music excerpts. Main Outcome Measures: NH and CI listeners evaluated country music piece on ... περισσότερα »
Cochlear Implant Surgery in the Elderly: The Feasibility of a Modified Suprameatal Approach Under Local Anesthesia.
Cochlear Implant Surgery in the Elderly: The Feasibility of a Modified Suprameatal Approach Under Local Anesthesia.: Objective: Although cochlear implantation is a relatively safe procedure, there is some reticence to subject elderly people, especially those with significant comorbidity, to the risks of general anesthesia. The purpose of the study was to explore the feasibility of cochlear implant surgery under local anesthesia and sedation in elderly people. Study Design: Case report study (Clinical Capsule Report). Setting: Single tertiary academic referral center. Patients: Seve... περισσότερα »
Correlation of CT, MR, and Histopathology in Incomplete Partition-II Cochlear Anomaly.
Correlation of CT, MR, and Histopathology in Incomplete Partition-II Cochlear Anomaly.: Objective: To correlate the computed tomography (CT) and magnetic resonance imaging (MR) findings in a patient with incomplete partition-type II (IP-II) anomaly with histopathology in a similar human temporal bone specimen. To discover the histologic correlate of a common finding on MR of an "apparent" interscalar septum (IS). Patients: A patient with sensorineural hearing loss and imaging findings characteristic of IP-II, and a patient with histopathologic IP-II anomaly. Intervention: High-resol...περισσότερα »
Neutrophil to Lymphocyte Ratio as a Predictive Marker of Vestibular Schwannoma Growth.
Neutrophil to Lymphocyte Ratio as a Predictive Marker of Vestibular Schwannoma Growth.: Objective: To examine the predictive value of neutrophil to lymphocyte ratio (NLR) for vestibular schwannoma (VS) growth. Study Design: Retrospective case-control study. Setting: Tertiary, referral center. Patients: Patients with sporadic VS and available NLR obtained within 1 year from the diagnosis were divided into two groups with growing or non-growing tumor. Patients with known conditions affecting NLR were excluded. Interventions: NLR and tumor growth as determined by linear measurements o... περισσότερα »
Loads and Coupling Modalities Influence the Performance of the Floating Mass Transducer as a Round Window Driver.
Loads and Coupling Modalities Influence the Performance of the Floating Mass Transducer as a Round Window Driver.: Hypothesis: High loads forcing the floating mass transducer (FMT) of a single active middle ear implant toward the round window membrane (RWM) affect the backward stimulation of the cochlea. Background: Various factors influence the backward stimulation of the cochlea. We investigated the effects of various loads applied to the FMT together with different coupling techniques at the fully exposed RWM on the vibration transmission. Methods: Experimental study on temporal...περισσότερα »
Inner Ear Active Hearing Device in Non-Otosclerotic, Severe, Mixed Hearing Loss.
Inner Ear Active Hearing Device in Non-Otosclerotic, Severe, Mixed Hearing Loss.: Objective: To verify the efficacy of a powerful active hearing device in a patient different from far-advanced otosclerosis, specifically when the stapes footplate is mobile. Patient: A patient with severe-to-profound mixed hearing loss, who was not benefiting from the use of a conventional hearing aid, was selected for an inner ear active implant. This was justified by a bone conductive threshold above 60 dB, which had discouraged any other rehabilitative solutions such as a bone conductive implant, o... περισσότερα »
Association between individual response to food taste and gastroesophageal symptoms.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Association between individual response to food taste and gastroesophageal symptoms.* J Dig Dis. 2015 Jun;16(6):337-41 Authors: Shibata T, Nakamura M, Omori T, Tahara T, Ichikawa Y, Okubo M, Ishizuka T, Nakagawa Y, Nagasaka M, Nakamura M, Arisawa T, Hirata I Abstract OBJECTIVE: Taste is an important element in food preferences. Gastroesophageal reflux disease (GERD) is related to lifestyles including eating habits. We aimed to investigate the relationship between responses to specific tastes and GERD. METHODS: Al... περισσότερα »
Acid suppression medications are associated with suboptimal weight loss after laparoscopic Roux-en-Y gastric bypass in patients older than 40 years.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Acid suppression medications are associated with suboptimal weight loss after laparoscopic Roux-en-Y gastric bypass in patients older than 40 years.* Surg Obes Relat Dis. 2015 May-Jun;11(3):585-90 Authors: Ward EK, Jensen-Otsu E, Schoen JA, Rothchild K, Mitchell B, Austin GL Abstract BACKGROUND: Bariatric surgery, including laparoscopic Roux-en-Y gastric bypass (LRYGB), achieves the greatest long-term weight loss in severe obesity. Approximately 50%-60% of severely obese patients have gastroesophageal reflux dis... περισσότερα »
Is preoperative manometry necessary for evaluating reflux symptoms in sleeve gastrectomy patients?
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Is preoperative manometry necessary for evaluating reflux symptoms in sleeve gastrectomy patients?* Surg Obes Relat Dis. 2015 May-Jun;11(3):546-51 Authors: Moon RC, Teixeira AF, Jawad MA Abstract BACKGROUND: The effect of laparoscopic sleeve gastrectomy (LSG) in gastroesophageal reflux disease (GERD) is controversial. However, it has been reported that up to 22% of patients presented with symptomatic GERD after LSG. The aim of our study was to evaluate the necessity of preoperative manometric testing in LSG patie... περισσότερα »
Defining the nature and implications of head turn preference in the preterm infant
Early Human Development from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1qYUXBN via IFTTT
Acute traumatic cord injury associated with ossified ligamentum flavum
Journal of Clinical Neuroscience from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SYVBFO via IFTTT
Selective nonoperative management of penetrating thoracic injury.
Background: Thoracic penetrating injury is a cause for up to one-fifth of all non-natural deaths. The aim of this study was to determine the success of selective nonoperative management (SNOM) of patients presenting with a penetrating thoracic injury (PTI). Methods: This was a prospective study of patients with PTI who presented to a level 1 Trauma Center between April 2012 and August 2012. Results: A total of 248 patients were included in the study, with 5.7% (n=14) requiring immediate emergency surgery. Overall, five of these 248 patients died, resulting in a mortality rate of 2.0%... περισσότερα »
A Rare Case of Bilateral Patellar Tendon Ruptures: A Case Report and Literature Review
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
Bilateral patellar tendon ruptures are rare. The majority of case reports describing bilateral patellar tendon ruptures have occurred in patients with predisposing factors to tendinopathy. We describe a case of bilateral patellar tendon rupture sustained following minimal trauma by a patient with no systemic disease or history of steroid use. Due to the rarity of […]
Robust Stability Stabilization and Control of a Class of Nonlinear Discrete Time Stochastic Systems
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
This paper studies robust stability, stabilization, and control for a class of nonlinear discrete time stochastic systems. Firstly, the easily testing criteria for stochastic stability and stochastic stabilizability are obtained via linear matrix inequalities (LMIs). Then a robust state feedback controller is designed such that the concerned system not only is internally stochastically stabilizable but […]
Concurrent Occurrence of Tumor in Colon and Small Bowel following Intestinal Obstruction: A Case Report and Review of the Literature
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
An intestinal obstruction occurs when either the small or large intestine is partly or completely blocked so it prevents passing the food or fluid through the small/large bowel. This blockage is due to the existence of a mechanical obstruction such as foreign material, mass, hernia, or volvulus. Common symptoms include cramping pain, nausea and vomiting, […]
Leveraging Comparative Genomics to Identify and Functionally Characterize Genes Associated with Sperm Phenotypes in Python bivittatus (Burmese Python)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
Comparative genomics approaches provide a means of leveraging functional genomics information from a highly annotated model organism’s genome (such as the mouse genome) in order to make physiological inferences about the role of genes and proteins in a less characterized organism’s genome (such as the Burmese python). We employed a comparative genomics approach to produce […]
health technology; 206 new citations
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
206 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: health technology These pubmed results were generated on 2016/04/20 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content […]
Professor Dr. Werner Bohndorf zum 90. Geburtstag
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1WETFrK via IFTTT
Acoustic Characteristics of Stridor in Multiple System Atrophy.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
Acoustic Characteristics of Stridor in Multiple System Atrophy. PLoS One. 2016;11(4):e0153935 Authors: Koo DL, Lee JY, Joo EY, Hong SB, Nam H Abstract Nocturnal stridor is a breathing disorder prevalent in patients with multiple system atrophy (MSA). An improved understanding of this breathing disorder is essential since nocturnal stridor carries a poor prognosis (an increased […]
Suboptimal Diagnostic Accuracy of Obstructive Sleep Apnea in One Database Does Not Invalidate Previous Observational Studies.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
Suboptimal Diagnostic Accuracy of Obstructive Sleep Apnea in One Database Does Not Invalidate Previous Observational Studies. Anesthesiology. 2016 May;124(5):1192-1193 Authors: Poeran J, Cozowicz C, Chung F, Mokhlesi B, Ramachandran SK, Memtsoudis SG PMID: 27093655 [PubMed – as supplied by publisher] from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VBwY91 via IFTTT
Menopause status is associated with circadian- and sleep-related alterations.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
Menopause status is associated with circadian- and sleep-related alterations. Menopause. 2016 Apr 7; Authors: Gómez-Santos C, Saura CB, Lucas JA, Castell P, Madrid JA, Garaulet M Abstract OBJECTIVE: The aim of the study was to investigate whether postmenopausal women show differences in circadian-related variables and sleep characteristics compared with premenopausal women, and to analyze potential […]
Occupational safety conditions of bus drivers in Metro Manila the Philippines.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
Occupational safety conditions of bus drivers in Metro Manila, the Philippines. Int J Occup Saf Ergon. 2016 Apr 19;:1-6 Authors: Santos JA, Lu JL Abstract The study looks into the occupational safety and working conditions among bus drivers in Metro Manila, the Philippines. Quantitative data were collected through survey interviews of 95 bus drivers using […]
Down-regulation of the large conductance Ca(2)-activated K() channel expression in C57BL/6J cochlea.
*Down-regulation of the large conductance Ca(2+)-activated K(+) channel expression in C57BL/6J cochlea.* Acta Otolaryngol. 2016 Apr 19;:1-4 Authors: Pan C, Chu H, Lai Y, Liu Y, Sun Y, Du Z, Chen J, Tong T, Chen Q, Zhou L, Bing D, Tao Y Abstract CONCLUSION: The large conductance Ca(2+)-activated K(+ )channels (BK) expression is decreased in the cochleae of age-related hearing loss (AHL) mice. BK channel may be associated with AHL. OBJECTIVE: AHL is the most common among elderly persons. BK channels act as sensors for membrane voltage and intracellular Ca(2+ )and are essential for ... περισσότερα »
The Nobel Prize and otolaryngology: 'Papa Gunnar's' promotion of his peers Gustav Killian and Themistocles Gluck.
*The Nobel Prize and otolaryngology: 'Papa Gunnar's' promotion of his peers Gustav Killian and Themistocles Gluck.* Acta Otolaryngol. 2016 Apr 19;:1-4 Authors: Hansson N, Halling T, Fangerau H Abstract OBJECTIVES: This study is part of a larger project investigating the enactment of excellence in medicine, with a focus on the Nobel Prize. It takes a closer look at two promising candidates for the Prize in the 1920s and 1930s, Gustav Killian and Themistocles Gluck, and aims at reconstructing their Nobel careers as well as taking Gunnar Holmgren's role as a nominator and evaluator ... περισσότερα »
The injury of marginal mandibular branch unexpectedly promotes the repair of buccal branch of facial nerve in a rat model.
*The injury of marginal mandibular branch unexpectedly promotes the repair of buccal branch of facial nerve in a rat model.* Acta Otolaryngol. 2016 Apr 19;:1-8 Authors: Chao X, Xu L, Shang H, Han Y, Cai J, Li J, Wang H, Fan Z Abstract CONCLUSIONS: The results indicate that the injury of the marginal mandibular branch improved the recovery of the buccal branch in a rat model. OBJECTIVE: The aim of this study was to investigate whether the injury or intactness of the marginal mandibular branch affects the regeneration of the facial nerve buccal branch in a rat model. METHODS: This ex...περισσότερα »
Erratum.
*Erratum.* Acta Otolaryngol. 2016 Apr 19;:1 Authors: PMID: 27093103 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SYTSAv via IFTTT
Is T-tube treatment effective in Meyer-Cotton grade 3 tracheal stenosis: long-term outcomes.
*Is T-tube treatment effective in Meyer-Cotton grade 3 tracheal stenosis: long-term outcomes.* Acta Otolaryngol. 2016 Apr 19;:1-4 Authors: Ozkul Y, Songu M, Ozturkcan S, Imre A, Erdogan N, Ates D, Ozkul Z Abstract OBJECTIVES: To present retrospective experience in Meyer-Cotton grade 3 tracheal stenosis of 17 patients treated by T-tube, considering the characteristics of the treated stenosis, surgical procedures performed, and post-operative outcomes and complications. METHODS: All demographic and clinical data were collected retrospectively. Chest and neck computed tomography scan...περισσότερα »
Impairment of homonymous processing in Alzheimer's disease.
[image: http:--production.springer.de-OnlineReso] Related Articles *Impairment of homonymous processing in Alzheimer's disease.* Neurol Sci. 2015 Aug;36(8):1331-6 Authors: Piccirilli M, D'Alessandro P, Micheletti N, Macone S, Scarponi L, Arcelli P, Petrillo SM, Silvestrini M, Luzzi S Abstract An important issue in research on language is how concepts are represented and associated with each other in the brain. Many investigations have focused on language ambiguity and the phenomenon of homonymy in which a single lexical item, presenting the same form, is related to different mean... περισσότερα »
Proceeding of the 2016 Meeting of the British Neurological Research Group.
*Proceeding of the 2016 Meeting of the British Neurological Research Group.* Br J Neurosurg. 2016 Apr 19;:1-14 Authors: PMID: 27090554 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SYTSjX via IFTTT
Diagnostic utility of intravoxel incoherent motion mr imaging in differentiating primary central nervous system lymphoma from glioblastoma multiforme.
*Diagnostic utility of intravoxel incoherent motion mr imaging in differentiating primary central nervous system lymphoma from glioblastoma multiforme.* J Magn Reson Imaging. 2016 Apr 19; Authors: Yamashita K, Hiwatashi A, Togao O, Kikuchi K, Kitamura Y, Mizoguchi M, Yoshimoto K, Kuga D, Suzuki SO, Baba S, Isoda T, Iwaki T, Iihara K, Honda H Abstract PURPOSE: To evaluate the diagnostic performance of intravoxel incoherent motion (IVIM) MR imaging and (18) F-fluorodeoxyglucose positron emission tomography (FDG-PET) in differentiating primary central nervous system lymphoma (PCNSL... περισσότερα »
A Japanese familial ALS patient with autonomic failure and a p.Cys146Arg mutation in the gene for SOD1 (SOD1).
*A Japanese familial ALS patient with autonomic failure and a p.Cys146Arg mutation in the gene for SOD1 (SOD1).* Neuropathology. 2016 Apr 18; Authors: Hayashi K, Mochizuki Y, Koide R, Kawata A, Homma T, Shimizu T, Komori T, Isozaki E Abstract We describe a Japanese man with familial amyotrophic lateral sclerosis (ALS) associated with a p.Cys146Arg mutation in the copper/zinc superoxide dismutase gene (SOD1). The patient developed bulbar signs followed by rapidly progressive limb muscle weakness. The prominent clinical feature was orthostatic hypotension due to autonomic failure, ... περισσότερα »
An autopsy case of cortical superficial siderosis with persistent abnormal behavior.
*An autopsy case of cortical superficial siderosis with persistent abnormal behavior.* Neuropathology. 2016 Apr 18; Authors: Torii Y, Iritani S, Fujishiro H, Sekiguchi H, Habuchi C, Umeda K, Matsunaga S, Mimuro M, Ozaki N, Yoshida M, Fujita K Abstract In recent years, MRI has revealed cortical superficial siderosis (cSS), which exhibits hemosiderin deposition in only the cortical surface. However, the associations between the histological findings and clinical symptoms of cSS remain unclear. We herein report an autopsy case of a 75-year-old Japanese man with cSS with persistent a... περισσότερα »
A case of intravascular large B cell lymphoma: New clinical and immunohistochemical findings.
*A case of intravascular large B cell lymphoma: New clinical and immunohistochemical findings.* Neuropathology. 2016 Apr 18; Authors: Mansueto G, Di Vito A, Belluomo C, Murino P, Natella V, Camastra C, Presta I, Malara N, de Rosa G, Donato G, Mignogna C Abstract Intravascular large B cell lymphoma (IVLBCL) is a rare extranodal non-Hodgkin lymphoma characterized by proliferation of malignant cells within the lumen of small vessels, with a predilection for the CNS and the skin. IVLBCL clinical course is highly aggressive, clinical signs and symptoms are not specific and may consist...περισσότερα »
Printed peptide arrays identify prognostic TNC serumantibodies in glioblastoma patients.
[image: http:--http://ift.tt/1kmBV5b] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Printed peptide arrays identify prognostic TNC serumantibodies in glioblastoma patients.* Oncotarget. 2015 May 30;6(15):13579-90 Authors: Mock A, Warta R, Geisenberger C, Bischoff R, Schulte A, Lamszus K, Stadler V, Felgenhauer T, Schichor C, Schwartz C, Matschke J, Jungk C, Ahmadi R, Sahm F, Capper D, Glass R, Tonn JC, Westphal M, von Deimling A, Unterberg A, Bermejo JL, Herold-Mende C Abstract Liquid biopsies come of age offering unexploited potential to monitor and react to tumor evo... περισσότερα »
E-cigarettes in ENT: what do we need to know?
*E-cigarettes in ENT: what do we need to know?* J Laryngol Otol. 2016 Apr 19;:1-4 Authors: Stobbs N, Lillis A, Kumar N Abstract BACKGROUND: E-cigarette use in the UK is increasing and we are commonly encountering patients in the ENT clinic who are e-cigarette smokers. Currently, there is no regulatory body or licensing for e-cigarettes. This means that the contents, and therefore potential carcinogenic and toxic risks, can vary greatly from product to product. Patients are starting to ask about the risks of e-cigarettes and their use in smoking cessation. OBJECTIVES: This review a... περισσότερα »
Of Tattooed Rabbits Parturients and Neuraxial Blocks.
*Of Tattooed Rabbits, Parturients, and Neuraxial Blocks.* Reg Anesth Pain Med. 2016 May-Jun;41(3):419-420 Authors: Kluger N, Sleth JC PMID: 27093287 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1WdKuOm via IFTTT
"Those Who Don't Remember the Past Are Condemned to Relive It": Dr. Alon P. Winnie and his Subclavian Perivascular Technique.
*"Those Who Don't Remember the Past Are Condemned to Relive It": Dr. Alon P. Winnie and his Subclavian Perivascular Technique.* Reg Anesth Pain Med. 2016 May-Jun;41(3):418-419 Authors: Muñoz R, Mojica V, Doreste M, Sala-Blanch X PMID: 27093286 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SYTP7G via IFTTT
Elastography: Another Method to Detect Intraneural Injection.
*Elastography: Another Method to Detect Intraneural Injection.* Reg Anesth Pain Med. 2016 May-Jun;41(3):417-418 Authors: Fajardo-Pérez M, Salazar-Zamorano CH, Aguilar-Gómez D, Llavador-Ros JJ, Monzó-Abad E PMID: 27093285 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1WdKuxY via IFTTT
The "Step-Off" Technique Can Confirm a Successful Peripheral Nerve Block.
*The "Step-Off" Technique Can Confirm a Successful Peripheral Nerve Block.* Reg Anesth Pain Med. 2016 May-Jun;41(3):417 Authors: Sutton E, Bullock WM, Gadsden J, Grant SA PMID: 27093284 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SYTPVo via IFTTT
A Novel Approach to the Treatment of Sacroiliac Joint Complex Pain: Bipolar Radiofrequency Ablation Applied in a Palisade Pattern.
*A Novel Approach to the Treatment of Sacroiliac Joint Complex Pain: Bipolar Radiofrequency Ablation Applied in a Palisade Pattern.* Reg Anesth Pain Med. 2016 May-Jun;41(3):416-417 Authors: Rejaei D, Singh N, Sheth S, Koebner I, Fishman SM PMID: 27093283 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1WdKuxL via IFTTT
Ultrasound-Guided Tibial Nerve Block for Definitive Treatment of Tarsal Tunnel Syndrome in a Pediatric Patient.
*Ultrasound-Guided Tibial Nerve Block for Definitive Treatment of Tarsal Tunnel Syndrome in a Pediatric Patient.* Reg Anesth Pain Med. 2016 May-Jun;41(3):415-416 Authors: Sobey JH, Franklin A PMID: 27093282 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SYTPV6 via IFTTT
Reply to Dr Ruan.
*Reply to Dr Ruan.* Reg Anesth Pain Med. 2016 May-Jun;41(3):414-415 Authors: Imamachi N, Saito Y PMID: 27093281 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1WdKrSQ via IFTTT
Comparative morphology and histology of the nasal fossa in four mammals: Gray squirrel bobcat coyote and white-tailed deer.
*Comparative morphology and histology of the nasal fossa in four mammals: Gray squirrel, bobcat, coyote and white-tailed deer.* Anat Rec (Hoboken). 2016 Apr 18; Authors: Yee KK, Craven BA, Wysocki CJ, Van Valkenburgh B Abstract Although the anatomy of the nasal fossa is broadly similar among terrestrial mammals, differences are evident in the intricacies of nasal turbinal architecture, which varies from simple scroll-like to complex branching forms, and in the extent of nonsensory and olfactory epithelium covering the turbinals. In this study, detailed morphological and immunohis... περισσότερα »
Does securin expression have significance in prognostication of oral tongue cancer? A pilot study.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
*Does securin expression have significance in prognostication of oral tongue cancer? A pilot study.* Eur Arch Otorhinolaryngol. 2016 Apr 18; Authors: Heikkinen I, Almangush A, Hagström J, Bello IO, Kauppila JH, Mäkinen LK, Haglund C, Nieminen P, Salo T, Leivo I Abstract The proliferation marker, securin, is involved in the progression of many carcinomas. However, its expression in oral tongue squamous cell carcinoma (OTSCC) has not been previously studied. We examined securin expression by immunohistochemistry in OTSCC. A total of 93 cases treated for OTSCC were included in this ... περισσότερα »
Health related quality of life following the treatment of oropharyngeal cancer by transoral laser.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
*Health related quality of life following the treatment of oropharyngeal cancer by transoral laser.* Eur Arch Otorhinolaryngol. 2016 Apr 18; Authors: Rogers SN, Pinto RS, Lancaster J, Bekiroglu F, Lowe D, Tandon S, Jones TM Abstract In 2006, our Institution changed the treatment strategy for small volume primary oropharyngeal tumours to transoral laser microsurgery (TOLM). The main aim of this cohort study was to report the health related quality of life (HRQOL) at around 2 years following TOLM in consecutive patients treated from July 2006 through April 2013. The University of W... περισσότερα »
Nimotuzumab increases the anti-tumor effect of photodynamic therapy in an oral tumor model.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
[image: http:--http://ift.tt/1kmBV5b] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Nimotuzumab increases the anti-tumor effect of photodynamic therapy in an oral tumor model.* Oncotarget. 2015 May 30;6(15):13487-505 Authors: Bhuvaneswari R, Ng QF, Thong PS, Soo KC Abstract Oral squamous cell carcinoma (OSCC) represents 90% of all oral cancers and is characterized with poor prognosis and low survival rate. Epidermal growth factor receptor (EGFR) is highly expressed in oral cancer and is a target for cancer therapy and prevention. In this present work, we evaluate the e... περισσότερα »
Immunohistochemical differentiation between type B3 thymomas and thymic squamous cell carcinomas.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Immunohistochemical differentiation between type B3 thymomas and thymic squamous cell carcinomas.* Int J Clin Exp Pathol. 2015;8(5):5354-62 Authors: Su XY, Wang WY, Li JN, Liao DY, Wu WL, Li GD Abstract Type B3 thymomas and thymic squamous cell carcinomas have some overlapping histological features, so it is difficult to make the differential diagnosis between these two entities, especially when the biopsy specimen is small. Only a few markers such as CD5 and CD 117 were applied to the differential diagnosis, the purpose of ... περισσότερα »
Elevated RET expression enhances EGFR activation and mediates EGFR inhibitor resistance in head and neck squamous cell carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
*Elevated RET expression enhances EGFR activation and mediates EGFR inhibitor resistance in head and neck squamous cell carcinoma.* Cancer Lett. 2016 Apr 15; Authors: Lin C, Lu W, Ren Z, Tang Y, Zhang C, Yang R, Chen Y, Cao W, Wang L, Wang X, Ji T Abstract BACKGROUND AND AIM: Co-activation of EGFR by alternative receptor tyrosine kinases (RTKs) might mediate resistance to EGFR inhibition in head and neck squamous cell carcinoma (HNSCC). Here we found novel mechanism to improve efficacy of EGFR inhibitor elortinib on HNSCC. METHOD: Immunohistochemistry, western blot, cell migration... περισσότερα »
Does securin expression have significance in prognostication of oral tongue cancer? A pilot study.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
*Does securin expression have significance in prognostication of oral tongue cancer? A pilot study.* Eur Arch Otorhinolaryngol. 2016 Apr 18; Authors: Heikkinen I, Almangush A, Hagström J, Bello IO, Kauppila JH, Mäkinen LK, Haglund C, Nieminen P, Salo T, Leivo I Abstract The proliferation marker, securin, is involved in the progression of many carcinomas. However, its expression in oral tongue squamous cell carcinoma (OTSCC) has not been previously studied. We examined securin expression by immunohistochemistry in OTSCC. A total of 93 cases treated for OTSCC were included in this ... περισσότερα »
Health related quality of life following the treatment of oropharyngeal cancer by transoral laser.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
*Health related quality of life following the treatment of oropharyngeal cancer by transoral laser.* Eur Arch Otorhinolaryngol. 2016 Apr 18; Authors: Rogers SN, Pinto RS, Lancaster J, Bekiroglu F, Lowe D, Tandon S, Jones TM Abstract In 2006, our Institution changed the treatment strategy for small volume primary oropharyngeal tumours to transoral laser microsurgery (TOLM). The main aim of this cohort study was to report the health related quality of life (HRQOL) at around 2 years following TOLM in consecutive patients treated from July 2006 through April 2013. The University of W... περισσότερα »
Cisplatin/Tegafur/Uracil/Irinotecan Triple Combination Therapy for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma: A Phase I/II Clinical Study.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
*Cisplatin/Tegafur/Uracil/Irinotecan Triple Combination Therapy for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma: A Phase I/II Clinical Study.* Oncologist. 2016 Apr 18; Authors: Chen SC, Chang PM, Yang MH Abstract LESSONS LEARNED: Cisplatin/tegafur/uracil/irinotecan triple combination therapy shows moderate response, especially in patients without previous chemoradiotherapy within the 6 months before this combination therapy.Toxicity is tolerable, and quality of life is improved in responders. BACKGROUND: The prognosis is poor in recurrent/metastatic head and neck ...περισσότερα »
Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology Neurochemistry and Clinical Implications.
*Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications.* Front Neurosci. 2016;10:148 Authors: Pei Y, Asif-Malik A, Canales JJ Abstract Biogenic amines are a collection of endogenous molecules that play pivotal roles as neurotransmitters and hormones. In addition to the "classical" biogenic amines resulting from decarboxylation of aromatic acids, including dopamine (DA), norepinephrine, epinephrine, serotonin (5-HT), and histamine, other biogenic amines, present at much lower concentrations in the central nervous system (CN...περισσότερα »
Prefrontal tDCS Decreases Pain in Patients with Multiple Sclerosis.
*Prefrontal tDCS Decreases Pain in Patients with Multiple Sclerosis.* Front Neurosci. 2016;10:147 Authors: Ayache SS, Palm U, Chalah MA, Al-Ani T, Brignol A, Abdellaoui M, Dimitri D, Sorel M, Créange A, Lefaucheur JP Abstract BACKGROUND: In the last few years, transcranial direct current stimulation (tDCS) has emerged as an appealing therapeutic option to improve brain functions. Promising data support the role of prefrontal tDCS in augmenting cognitive performance and ameliorating several neuropsychiatric symptoms, namely pain, fatigue, mood disturbances, and attentional impairme... περισσότερα »
Comparative morphology and histology of the nasal fossa in four mammals: Gray squirrel, bobcat, coyote and white-tailed deer.
*Comparative morphology and histology of the nasal fossa in four mammals: Gray squirrel, bobcat, coyote and white-tailed deer.* Anat Rec (Hoboken). 2016 Apr 18; Authors: Yee KK, Craven BA, Wysocki CJ, Van Valkenburgh B Abstract Although the anatomy of the nasal fossa is broadly similar among terrestrial mammals, differences are evident in the intricacies of nasal turbinal architecture, which varies from simple scroll-like to complex branching forms, and in the extent of nonsensory and olfactory epithelium covering the turbinals. In this study, detailed morphological and immunohis... περισσότερα »
Gut Microbiota of Nonalcoholic Fatty Liver Disease
Abstract The prevalence of nonalcoholic fatty liver disease has been rapidly increasing worldwide. It has become a leading cause of liver transplantation. Accumulating evidence suggests a significant role for gut microbiota in its development and progression. Here we review the effect of gut microbiota on developing hepatic fatty infiltration and its progression. Current literature supports a possible role for gut microbiota in the development of liver steatosis, inflammation and fibrosis. We also review the literature on possible interventions for NAFLD that target the gut microb... περισσότερα »
Natural History of Nonalcoholic Fatty Liver Disease
Abstract Nonalcoholic fatty liver disease (NAFLD) remains among the most common liver diseases worldwide, with increasing prevalence in concert with the obesity and metabolic syndrome epidemic. The evidence on the natural history, albeit with some ambiguity, suggests the potential for some subsets of NAFLD to progress to cirrhosis, liver-related complications and mortality with fibrosis being the most important predictor of hard long-term endpoints such as mortality and liver complications. In this setting, NAFLD proves to be a formidable disease entity, with considerable clinical...περισσότερα »
Fibrosis Assessment in Nonalcoholic Fatty Liver Disease (NAFLD) in 2016
Abstract Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver pathologies characterized by hepatic steatosis with a history of little to no alcohol consumption or secondary causes of hepatic steatosis. The prevalence of NAFLD is 20–25 % of the general population in the Western countries and is associated with metabolic risk factors such as obesity, diabetes mellitus, and dyslipidemia. The spectrum of disease ranges from simple steatosis to nonalcoholic steatohepatitis, fibrosis, and cirrhosis. Advanced fibrosis is the most significant predictor of mortality in NAFLD. It ... περισσότερα »
Novel Pharmacotherapy Options for NASH
Abstract While simple to recommend, diet and lifestyle measures as a first-line therapy for nonalcoholic steatohepatitis (NASH) are hardly a model of successful therapy, as most clinicians can testify. They can be complex to implement, hard to sustain, and of limited efficacy in advanced stages of the disease. The need for specific pharmacotherapy is now acknowledged by practitioners, the pharmaceutical industry, and regulators and is largely expected by patients. The result is a clear move away from products developed second hand for NASH (such as pioglitazone or metformin) or fro...περισσότερα »
Global Epidemiology of Nonalcoholic Fatty Liver Disease and Perspectives on US Minority Populations
Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a clinical syndrome predicted to be the next global epidemic affecting millions of people worldwide. The natural course of this disease including its subtype, non-alcoholic steatohepatitis (NASH), is not clearly defined especially in the African-American segment of the US population. Aims To conduct a review of the global epidemiology of NAFLD with emphasis on US minority populations. Methods A thorough search of evidence-based literature was conducted using the Pubmed database and commercial web sources such as Me...περισσότερα »
The 8th Auger Symposium: Preface
10.3109/09553002.2016.1153167<br>Akinari Yokoya from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1Vj0HD5 via IFTTT
A 10-year study reveals clinical and laboratory evidence for the ‘semi-invasive’ properties of chronic pulmonary aspergillosis
*A 10-year study reveals clinical and laboratory evidence for the 'semi-invasive' properties of chronic pulmonary aspergillosis* Emerging Microbes & Infections 5, e37 (April 2016). doi:10.1038/emi.2016.31 Authors: Jasper Fuk-Woo Chan, Susanna Kar-Pui Lau, Sally Cheuk-Ying Wong, Kelvin Kai-Wang To, Simon Yung-Chun So, Sally Sau-Man Leung, Siu-Mang Chan, Chiu-Mei Pang, Chenlu Xiao, Ivan Fan-Ngai Hung, Vincent Chi-Chung Cheng, Kwok-Yung Yuen & Patrick Chiu-Yat Woo from Infection via ola Kala on Inoreader http://ift.tt/1riVDCp via IFTTT
The replication of Bangladeshi H9N2 avian influenza viruses carrying genes from H7N3 in mammals
*The replication of Bangladeshi H9N2 avian influenza viruses carrying genes from H7N3 in mammals* Emerging Microbes & Infections 5, e35 (April 2016). doi:10.1038/emi.2016.29 Authors: Karthik K Shanmuganatham, Jeremy C Jones, Bindumadhav M Marathe, Mohammed M Feeroz, Lisa Jones-Engel, David Walker, Jasmine Turner, S M Rabiul Alam, M Kamrul Hasan, Sharmin Akhtar, Patrick Seiler, Pamela McKenzie, Scott Krauss, Richard J Webby & Robert G Webster from Infection via ola Kala on Inoreader http://ift.tt/1Sk8VVC via IFTTT
MiR-124 is differentially expressed in derivatives of the sympathoadrenal cell lineage and promotes neurite elongation in chromaffin cells
Abstract The neural-crest-derived sympathoadrenal cell lineage gives rise to sympathetic neurons and to endocrine chromaffin cells of the adrenal medulla. Both cell types express a largely overlapping set of genes, including those coding for the molecular machinery related to the synthesis and exocytotic release of catecholamines. During their early development, sympathetic neurons and chromaffin cells rely on a shared transcription factor network that controls the establishment of these common features. Despite many similarities, mature sympathetic neurons and chromaffin cells si...περισσότερα »
Nonalcoholic Fatty Liver Disease: Key Considerations Before and After Liver Transplantation
Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common etiology of chronic liver disease in developed countries and is on trajectory to become the leading indication for liver transplantation in the USA and much of the world. Patients with NAFLD cirrhosis awaiting liver transplant face unique challenges and increased risk for waiting list stagnation and dropout due to burdensome comorbidities including obesity, diabetes, cardiovascular disease, and kidney disease. Thus far, patients transplanted for NAFLD cirrhosis have excellent mid- and long-term patient and graft s... περισσότερα »
Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame
Abstract With the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become a public health problem with increasing prevalence. The mechanism of disease progression remains obscure and effective therapy is lacking. Therefore, there is a need to understand the pathogenic mechanisms responsible for disease development and progression in order to develop innovative therapies. To accomplish this goal, experimental animal models that recapitulate the human disease are necessary, especially, since causative mechanistic studies of NAFLD are more difficult or unethical to perf... περισσότερα »
Hepatocellular Carcinoma in Obesity, Type 2 Diabetes, and NAFLD
Abstract Hepatocellular carcinoma (HCC) is the second commonest cause of cancer death worldwide. Rather than falling as a result of prevention and treatments for viral hepatitis, an increase is evident in developed nations consequent to the rising prevalence of obesity and type 2 diabetes mellitus (T2DM)—the two major risk factors for nonalcoholic fatty liver disease (NAFLD). The majority of patients with HCC complicating these conditions present with advanced disease as the tools for surveillance are inadequate, and the "at-risk" population is not well characterized. This review w... περισσότερα »
Low prevalence of human papillomavirus in oral cavity squamous cell carcinoma in Queensland Australia.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Low prevalence of human papillomavirus in oral cavity squamous cell carcinoma in Queensland, Australia.* ANZ J Surg. 2016 Apr 18; Authors: Emmett S, Jenkins G, Boros S, Whiteman DC, Panizza B, Antonsson A Abstract BACKGROUND: While human papillomavirus (HPV) is an accepted risk factor for oropharyngeal squamous cell carcinoma (SCC), its aetiological role in oral cavity SCC remains unclear. This study aimed to determine the HPV prevalence in an Australian population. METHODS: DNA was extracted from 63 formalin-fixed paraffin-embedded tumour specimens histologically confirmed as SC... περισσότερα »
Comparative morphology and histology of the nasal fossa in four mammals: Gray squirrel bobcat coyote and white-tailed deer.
*Comparative morphology and histology of the nasal fossa in four mammals: Gray squirrel, bobcat, coyote and white-tailed deer.* Anat Rec (Hoboken). 2016 Apr 18; Authors: Yee KK, Craven BA, Wysocki CJ, Van Valkenburgh B Abstract Although the anatomy of the nasal fossa is broadly similar among terrestrial mammals, differences are evident in the intricacies of nasal turbinal architecture, which varies from simple scroll-like to complex branching forms, and in the extent of nonsensory and olfactory epithelium covering the turbinals. In this study, detailed morphological and immunohis... περισσότερα »
Comparative morphology and histology of the nasal fossa in four mammals: Gray squirrel bobcat coyote and white-tailed deer.
*Comparative morphology and histology of the nasal fossa in four mammals: Gray squirrel, bobcat, coyote and white-tailed deer.* Anat Rec (Hoboken). 2016 Apr 18; Authors: Yee KK, Craven BA, Wysocki CJ, Van Valkenburgh B Abstract Although the anatomy of the nasal fossa is broadly similar among terrestrial mammals, differences are evident in the intricacies of nasal turbinal architecture, which varies from simple scroll-like to complex branching forms, and in the extent of nonsensory and olfactory epithelium covering the turbinals. In this study, detailed morphological and immunohis... περισσότερα »
MANAGEMENT OF ENDOCRINE DISEASE: ACROMEGALY AND CANCER: AN OLD DEBATE REVISITED.
*MANAGEMENT OF ENDOCRINE DISEASE: ACROMEGALY AND CANCER: AN OLD DEBATE REVISITED.* Eur J Endocrinol. 2016 Apr 18; Authors: Boguszewski CL, Ayuk J Abstract Based on experimental and animal models, epidemiological data from non-acromegaly populations, and longitudinal and cross-sectional cohorts of patients with acromegaly, a potential association between acromegaly and cancer has long been hypothesized, in particular colorectal cancer, and to a lesser extent breast, thyroid, and prostate cancers. The exact mechanisms underlying this potential association have not been fully elucid... περισσότερα »
Association of TERT Promoter Mutation, But Not BRAF Mutation, With Increased Mortality in PTC.
Related Articles *Association of TERT Promoter Mutation, But Not BRAF Mutation, With Increased Mortality in PTC.* J Clin Endocrinol Metab. 2015 Dec;100(12):E1550-9 Authors: George JR, Henderson YC, Williams MD, Roberts DB, Hei H, Lai SY, Clayman GL Abstract CONTEXT: Papillary thyroid carcinoma (PTC) carrying the BRAF mutation has been reported to be associated with high recurrence and potentially increased mortality. PTC carrying the TERT promoter mutation has been associated with older age, recurrence, and aggressive disease. OBJECTIVE: The objective of this study was to determi...περισσότερα »
Photodynamic Therapy for Choroidal Metastasis.
Related Articles *Photodynamic Therapy for Choroidal Metastasis.* Am J Ophthalmol. 2016 Jan;161:104-9.e1-2 Authors: Ghodasra DH, Demirci H Abstract PURPOSE: To evaluate the effectiveness of photodynamic therapy (PDT) in the management of choroidal metastasis. DESIGN: Retrospective, interventional case series. METHODS: Patients with choroidal metastasis treated with PDT at a single institution were reviewed. PDT was applied with verteporfin at a dose of 6 mg/m(2) body surface area and a 689 nm diode laser for 83 seconds. Visual acuity, tumor basal diameter, tumor thickness by ultra... περισσότερα »
Allan-Herndon-Dudley syndrome with unusual profound sensorineural hearing loss.
Related Articles *Allan-Herndon-Dudley syndrome with unusual profound sensorineural hearing loss.* Am J Med Genet A. 2015 Aug;167A(8):1872-6 Authors: Gagliardi L, Nataren N, Feng J, Schreiber AW, Hahn CN, Conwell LS, Coman D, Scott HS Abstract The Allan-Herndon-Dudley syndrome is caused by mutations in the thyroid hormone transporter, Monocarboxylate transporter 8 (MCT8). It is characterized by profound intellectual disability and abnormal thyroid function. We report on a patient with Allan-Herndon-Dudley syndrome (AHDS) with profound sensorineural hearing loss which is not usua... περισσότερα »
Association of TERT Promoter Mutation, But Not BRAF Mutation, With Increased Mortality in PTC.
Related Articles *Association of TERT Promoter Mutation, But Not BRAF Mutation, With Increased Mortality in PTC.* J Clin Endocrinol Metab. 2015 Dec;100(12):E1550-9 Authors: George JR, Henderson YC, Williams MD, Roberts DB, Hei H, Lai SY, Clayman GL Abstract CONTEXT: Papillary thyroid carcinoma (PTC) carrying the BRAF mutation has been reported to be associated with high recurrence and potentially increased mortality. PTC carrying the TERT promoter mutation has been associated with older age, recurrence, and aggressive disease. OBJECTIVE: The objective of this study was to determi...περισσότερα »
Photodynamic Therapy for Choroidal Metastasis.
Related Articles *Photodynamic Therapy for Choroidal Metastasis.* Am J Ophthalmol. 2016 Jan;161:104-9.e1-2 Authors: Ghodasra DH, Demirci H Abstract PURPOSE: To evaluate the effectiveness of photodynamic therapy (PDT) in the management of choroidal metastasis. DESIGN: Retrospective, interventional case series. METHODS: Patients with choroidal metastasis treated with PDT at a single institution were reviewed. PDT was applied with verteporfin at a dose of 6 mg/m(2) body surface area and a 689 nm diode laser for 83 seconds. Visual acuity, tumor basal diameter, tumor thickness by ultra... περισσότερα »
Allan-Herndon-Dudley syndrome with unusual profound sensorineural hearing loss.
Related Articles *Allan-Herndon-Dudley syndrome with unusual profound sensorineural hearing loss.* Am J Med Genet A. 2015 Aug;167A(8):1872-6 Authors: Gagliardi L, Nataren N, Feng J, Schreiber AW, Hahn CN, Conwell LS, Coman D, Scott HS Abstract The Allan-Herndon-Dudley syndrome is caused by mutations in the thyroid hormone transporter, Monocarboxylate transporter 8 (MCT8). It is characterized by profound intellectual disability and abnormal thyroid function. We report on a patient with Allan-Herndon-Dudley syndrome (AHDS) with profound sensorineural hearing loss which is not usua... περισσότερα »
Exploring information from the topology beneath the Gene Ontology terms to improve semantic similarity measures
Publication date: 15 July 2016 Source:Gene, Volume 586, Issue 1 Author(s): Shu-Bo Zhang, Jian-Huang Lai Measuring the similarity between pairs of biological entities is important in molecular biology. The introduction of Gene Ontology (GO) provides us with a promising approach to quantifying the semantic similarity between two genes or gene products. This kind of similarity… Continue reading Exploring information from the topology beneath the Gene Ontology terms to improve semantic similarity measures
Nasjonalrett i fare!
Hva skjer hvis «grandisen» blir kalorimerket? from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/22NfGEu via IFTTT
Induction of Regulatory T Cells as a Novel Mechanism Underlying the Therapeutic Action of Kakkonto a Traditional Japanese Herbal Medicine in a Murine Food Allergy Model
Background: The number of patients with food allergy (FA) has dramatically increased. Although satisfactory drug therapies for FA are not available, we have found that kakkonto, a traditional Japanese herbal medicine, suppressed the occurrence of allergic symptoms in an FA mouse model. Thus, we investigated whether kakkonto could regulate the activation and differentiation of T… Continue reading Induction of Regulatory T Cells as a Novel Mechanism Underlying the Therapeutic Action of Kakkonto a Traditional Japanese Herbal Medicine in a Murine Food Allergy Model
Occupational exposures to engine exhausts and other PAHs and breast cancer risk: A population-based case-control study
Background Some previous studies have suggested that exposure to engine exhausts may increase risk of breast cancer. Methods In a population-based case-control study of breast cancer in Western Australia we assessed occupational exposure to engine exhausts using questionnaires and telephone interviews. Odds Ratios (OR) and 95% Confidence Intervals (CI) were calculated using logistic regression. Results… Continue reading Occupational exposures to engine exhausts and other PAHs and breast cancer risk: A population-based case-control study
Evaluation of a participatory ergonomics intervention in small commercial construction firms
Background Work-related musculoskeletal disorders (WMSD) among construction workers remain high. Participatory ergonomics (PE) interventions that engage workers and employers in reducing work injury risks have shown mixed results. Methods Eight-six workers from seven contractors participated in a PE program. A logic model guided the process evaluation and summative evaluation of short-term and intermediate impacts and… Continue reading Evaluation of a participatory ergonomics intervention in small commercial construction firms
Police officers who responded to 9/11: Comorbidity of PTSD depression and anxiety 1011 years later
Background After the 9/11/2001 World Trade Center (WTC) attack, many police-responders developed PTSD and might be vulnerable to develop depression and/or anxiety. Comorbidity of PTSD, depression, and/or anxiety is examined. Method Police enrollees (N = 1,884) from the WTC Health Registry were categorized into four groups based on comorbidity of PTSD, depression, and anxiety. DSM-IV diagnostic criteria… Continue reading Police officers who responded to 9/11: Comorbidity of PTSD depression and anxiety 1011 years later
A meta-analysis of studies investigating the effects of occupational lead exposure on thyroid hormones
Introduction Investigations of the effects of occupational exposure to lead on the concentrations of thyroid hormones in the blood have not produced consistent results. A meta-analysis was performed to assess the effect of occupational exposure to lead on thyroid hormone concentrations using the results from published studies. Methods Group means from studies of the thyroid… Continue reading A meta-analysis of studies investigating the effects of occupational lead exposure on thyroid hormones
Comments on the causation of malignant mesothelioma: Rebutting the false concept that recent exposures to asbestos do not contribute to causation of mesothelioma
Abstract The Collegium Ramazzini is an international scientific society that examines critical issues in occupational and environmental medicine with a view towards action to prevent disease and promote health. The Collegium derives its name from Bernardino Ramazzini, the father of occupational medicine, a professor of medicine of the Universities of Modena and Padua in the… Continue reading Comments on the causation of malignant mesothelioma: Rebutting the false concept that recent exposures to asbestos do not contribute to causation of mesothelioma
Genetic mutation linked to breast cancer may also reduce women’s eggs ‘reserve’ – BT.com
Genetic mutation linked to breast cancer may also reduce women’s eggs ‘reserve’ BT.com Women who carry a genetic mutation linked to breast cancer may also have a reduced «reserve» of eggs, a study has found. Scientists urged women carrying the BRCA1 mutation to avoid delaying pregnancy until an age when it becomes more difficult to… Continue reading Genetic mutation linked to breast cancer may also reduce women’s eggs ‘reserve’ – BT.com
Extracranial internal carotid artery pseudoaneurysm in a two-year-old child: case report
Rapid Communication M Roos, I Butler The Journal of Laryngology & Otology,FirstView Article(s), 4 pages Abstract from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1VDPnBt via IFTTT
Evaluation of a participatory ergonomics intervention in small commercial construction firms
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background Work-related musculoskeletal disorders (WMSD) among construction workers remain high. Participatory ergonomics (PE) interventions that engage workers and employers in reducing work injury risks have shown mixed results. Methods Eight-six workers from seven contractors participated in a PE program. A logic model guided the process evaluation and summative evaluation of short-term and intermediate impacts and […]
Police officers who responded to 9/11: Comorbidity of PTSD depression and anxiety 1011 years later
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background After the 9/11/2001 World Trade Center (WTC) attack, many police-responders developed PTSD and might be vulnerable to develop depression and/or anxiety. Comorbidity of PTSD, depression, and/or anxiety is examined. Method Police enrollees (N = 1,884) from the WTC Health Registry were categorized into four groups based on comorbidity of PTSD, depression, and anxiety. DSM-IV diagnostic criteria […]
A meta-analysis of studies investigating the effects of occupational lead exposure on thyroid hormones
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Introduction Investigations of the effects of occupational exposure to lead on the concentrations of thyroid hormones in the blood have not produced consistent results. A meta-analysis was performed to assess the effect of occupational exposure to lead on thyroid hormone concentrations using the results from published studies. Methods Group means from studies of the thyroid […]
Comments on the causation of malignant mesothelioma: Rebutting the false concept that recent exposures to asbestos do not contribute to causation of mesothelioma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract The Collegium Ramazzini is an international scientific society that examines critical issues in occupational and environmental medicine with a view towards action to prevent disease and promote health. The Collegium derives its name from Bernardino Ramazzini, the father of occupational medicine, a professor of medicine of the Universities of Modena and Padua in the […]
Genetic mutation linked to breast cancer may also reduce women’s eggs ‘reserve’ – BT.com
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Genetic mutation linked to breast cancer may also reduce women’s eggs ‘reserve’ BT.com Women who carry a genetic mutation linked to breast cancer may also have a reduced «reserve» of eggs, a study has found. Scientists urged women carrying the BRCA1 mutation to avoid delaying pregnancy until an age when it becomes more difficult to […]
Genetic Variants of CD40 Gene Are Associated with Coronary Artery Disease and Blood Lipid Levels
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives. The present study aimed to evaluate the effect of CD40 and CXCR4 genes polymorphisms on CAD susceptibility and the blood lipid levels and history of cardiovascular risk factors in a Chinese Han population. Materials and Methods. A total of 583 unrelated patients with CAD and 540 controls were recruited. Two tag SNPs (rs4239702 and […]
A Fomitopsis pinicola Jeseng Formulation Has an Antiobesity Effect and Protects against Hepatic Steatosis in Mice with High-Fat Diet-Induced Obesity
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This study investigated the antiobesity effect of an extract of the Fomitopsis pinicola Jeseng-containing formulation (FAVA), which is a combination of four natural components: Fomitopsis pinicola Jeseng; Acanthopanax senticosus; Viscum album coloratum; and Allium tuberosum. High-fat diet- (HFD-) fed male C57BL/6J mice were treated with FAVA (200 mg/kg/day) for 12 weeks to monitor the antiobesity effect […]
Extracranial internal carotid artery pseudoaneurysm in a two-year-old child: case report
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Rapid Communication M Roos, I Butler The Journal of Laryngology & Otology,FirstView Article(s), 4 pages Abstract from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VDPnBt via IFTTT
Brushing your teeth could ward off DEADLY bacteria linked to pancreatic cancer – Express.co.uk
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Express.co.uk Brushing your teeth could ward off DEADLY bacteria linked to pancreatic cancer Express.co.uk Speaking to the Mail Online, Dr Nigel Carter, CEO of the UK Oral Health Foundation, said: “Further investigation into this association needs to be carried out but if confirmed there’s no reason why a saliva test to detect for pancreatic cancer […]
Optimized Outcomes Using a Standardized Approach for Treatment of Patients with Carcinoid Heart Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: Carcinoid heart disease (CHD) is common in patients with carcinoid syndrome (CS). Surgical treatment improves the poor prognosis of CHD, although the reported perioperative mortality is high (∼17%). We attempted to improve outcomes by implementation of a protocol for the management of patients with CHD at a UK Neuroendocrine Centre of Excellence and report […]
HPV and Oropharyngeal Cancer Mystery: A glimmer of hope!
Abstract Viral associated cancer brings to forth the intricate relationships between viruses and host innate immunity and genetic susceptibility1. This interplay is particularly germane to viral associated nasopharyngeal and oropharyngeal squamous carcinomas, where lymphoid rich submucosa characterizes these sites. The inability of the existing immune defenses to neutralize EBV and HPV (both are dsDNA viruses) is currently unknown. This is largely due to the lack of direct cause/effect, the ubiquitous presence of these viruses and the unique demographic and epidemiologic character...περισσότερα »
The Fracture Toughness of Eggshell
Publication date: Available online 19 April 2016 *Source:*Acta Biomaterialia Author(s): David Taylor, Megan Walsh, Alexandra Cullen, Peter O'Reilly The shells of avian eggs are very brittle, but how brittle? Fracture toughness, Kc is a standard measure used widely to characterise engineering materials. We devised a novel way to measure Kc and applied it to commercial hens' eggs, obtaining a value of 0.3 MPa√m. This value is much lower than previous published values, which we argue are incorrect and misleading. We discuss how this exceptionally low toughness value (in comparison to t...περισσότερα »
Paclitaxel-loaded solid lipid nanoparticles modified with Tyr-3-octreotide for enhanced anti-angiogenic and anti-glioma therapy
Publication date: Available online 19 April 2016 *Source:*Acta Biomaterialia Author(s): Indranil Banerjee, Kakali De, Dibyanti Mukherjee, Goutam Dey, Sankha Chattopadhyay, Manabendra Mukherjee, Mahitosh Mandal, Amal Kumar Bandyopadhyay, Amit Gupta, Santanu Ganguly, Mridula Misra Somatostatin receptors (SSTRs) especially subtype 2 (SSTR2) are overexpressed in glioma. By taking advantage of the specific expression of SSTR2 on both glioma neovasculature endothelial cells and glioma cells, we constructed Tyr-3-octreotide (TOC)-modified solid lipid nanoparticles (SLN) loaded with paclita... περισσότερα »
The Design of Antimicrobial LL37-Modified Collagen-Hyaluronic Acid Detachable Multilayers
Publication date: Available online 19 April 2016 *Source:*Acta Biomaterialia Author(s): Margaret E. Cassin, Andrew J. Ford, Sophia M. Orbach, Scott E. Saverot, Padmavathy Rajagopalan The design of antimicrobial membranes and thin films are critical for the design of biomaterials that can combat bacterial contamination. Since the long-term use of conventional antibiotics can result in bacterial resistance, there is a critical need to incorporate natural antimicrobial peptides (AMPs) that not only prevent a wide range of pathogens from causing infections but can also promote many bene... περισσότερα »
Guiding cell migration with microscale stiffness patterns and undulated surfaces
Publication date: Available online 19 April 2016 *Source:*Acta Biomaterialia Author(s): Jonathan T. Pham, Longjian Xue, Aránzazu del Campo, Marcelo Salierno By placing stiff structures under soft materials, prior studies have demonstrated that cells sense and prefer to position themselves over the stiff structures. However, an understanding of how cells migrate on such surfaces has not been established. Many studies have also shown that cells readily align to surface topography. Here we investigate the influence of these two aspects in directing cell migration on surfaces with 5 and... περισσότερα »
An Alginate-based Platform for Cancer Stem Cell Research
Publication date: Available online 19 April 2016 *Source:*Acta Biomaterialia Author(s): Shu-pei Qiao, Yu-fang Zhao, Chun-feng Li, Yan-bin Yin, Qing-yuan Meng, Feng-Huei Lin, Yi Liu, Xiao-lu Hou, Kai Guo, Xiong-biao Chen, Wei-ming Tian As the primary determinants of the clinical behaviors of human cancers, the discovery of cancer stem cells (CSCs) represents an ideal target for novel anti-cancer therapies [1]. Notably, CSCs are difficult to propagate in vitro, which severely restricts the study of CSC biology and the development of therapeutic agents. Emerging evidence indicates that... περισσότερα »
Prevalence and Influencing Factors of Thyroid Dysfunction in HIV-Infected Patients
Thyroid dysfunction is more common in human immunodeficiency virus (HIV) patients. But the effects of highly active antiretroviral therapy (HAART) and hepatitis B/C virus (HBV/HCV) coinfection on thyroid function is unclear. We retrospectively reviewed the data of 178 HIV patients and determined the prevalence of thyroid dysfunction and the relationship between thyroid hormone levels, CD4 cell count, HIV-1 duration, HAART duration/regimens, and HBV/HCV coinfection. Of the 178 patients, 59 (33.1%) had thyroid dysfunction, mostly hypothyroidism. Thyroid dysfunction was significantly... περισσότερα »
The 8th Auger Symposium: Preface
10.3109/09553002.2016.1153167<br>Akinari Yokoya from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1Vj0HD5 via IFTTT
Icariin Prevents Cartilage and Bone Degradation in Experimental Models of Arthritis
Background. Icariin (ICA) is an active compound extracted from Epimedium brevicornum Maxim. Previous reports have shown that icariin has a clinically significant therapeutic effect on rheumatoid arthritis. However, little is known about the mechanism by which icariin inhibits cartilage and bone degradation. Methods. New Zealand rabbits were immunized with antigen-induced arthritis (AIA) and treated with icariin. Joint tissues from rabbits were studied by histological analysis, transmission electron microscopy (TEM), and micro-CT. The expression levels of receptor activator of nucl... περισσότερα »
Cell Recruiting Chemokine-Loaded Sprayable Gelatin Hydrogel Dressings for Diabetic Wound Healing
Publication date: Available online 19 April 2016 *Source:*Acta Biomaterialia Author(s): Dong Suk Yoon, Yunki Lee, Hyun Aae Ryu, Yeonsue Jang, Kyoung-Mi Lee, Yoorim Choi, Woo Jin Choi, Moses Lee, Kyung Min Park, Ki Dong Park, Jin Woo Lee In this study, we developed horseradish peroxidase (HRP)-catalyzed sprayable gelatin hydrogels (GH) as a bioactive wound dressing that can deliver cell-attracting chemotactic cytokines to the injured tissues for diabetic wound healing. We hypothesized that topical administration of chemokines using GH hydrogels might improve wound healing by inducing...περισσότερα »
Fabrication and characteristics of dual functionalized vascular stent by spatio-temporal coating
Publication date: Available online 19 April 2016 *Source:*Acta Biomaterialia Author(s): Seong Min Kim, Kwang-Sook Park, Eugene Lih, Young Joon Hong, Jong Hee Kang, Ik Hwan Kim, Myung Ho Jeong, Yoon Ki Joung, Dong Keun Han Stent implantation with balloon angioplasty is a widely used treatment for coronary artery diseases. Stents have been developed from bare metal stent (BMS) to advanced forms such as drug-eluting stent (DES). However, modern DES still causes thrombosis and/or in-stent restenosis as long-term outcomes. For effective prevention of these problems, we fabricated a dual ... περισσότερα »
Clinical use of the resorbable bioscaffold poly lactic co-glycolic acid (PLGA) in post-extraction socket for maintaining the alveolar height: A prospective study
Publication date: Available online 19 April 2016 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Nadeemul Hoda, Aamir Malick Saifi, Girish B. Giraddi BackgroundA common sequel of tooth extraction is alveolar bone resorption. It makes the placement of dental implants difficult and creates an esthetic problem for the fabrication of conventional prostheses. Therefore, alveolar bone following tooth extraction should be preserved.Aims and objectivesThe present prospective study was conducted to evaluate the efficacy of the resorbable bioscaffold poly lactic co-glycol...περισσότερα »
Clinical Usefulness of Mandibular Reconstruction Using Custom-Made Titanium Mesh Tray and Autogenous Particulate Cancellous Bone and Marrow Harvested From Tibia and/or Ilia.
The objective of this study was to evaluate usefulness of mandibular reconstructions using custom-made titanium mesh (Ti-mesh) tray and particulate cancellous bone and marrow (PCBM). Consecutive 21 patients who underwent mandibular reconstruction were enrolled in this study. They were 13 men and 8 women (mean age, 52.0 years). Virtual reality simulation was performed using computer software based on the preoperative computed tomography data. A 3-dimensional skull model was constructed using 3-dimensional printer. A tray was custom-made from Ti-mesh sheet bent to adapt to the model. ... περισσότερα »
Review of "A Trial of Wound Irrigation in the Initial Management of Open Fracture Wounds" by the FLOW Investigators in N Engl J Med 373: 2629-2641 2015.
No abstract available from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1MHo5r9 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Histologic and Histomorphometric Comparison of Bone Regeneration Between Bone Morphogenetic Protein-2 and Platelet-Derived Growth Factor-BB in Experimental Groups.
Efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) and recombinant human platelet-derived growth factor-BB (rhPDGF-BB) delivered via absorbable collagen sponge (ACS) on bone formation was evaluated in guinea pig tibias. Three-millimeter-circular bone tibia defects were created in 24 guinea pigs assigned randomly to 4 groups according to the following defect filling materials: ACS only, rhBMP-2+ACS, rhPDGF-BB+ACS, or empty. New bone formation was evaluated histologically and histomorphometrically at 15 (early healing) and 45 days (late healing). Mean new bone per to...περισσότερα »
Medication-Related Osteonecrosis of the Jaw Around Dental Implants: Implant Surgery-Triggered or Implant Presence-Triggered Osteonecrosis?.
Introduction: Dentoalveolar surgery including tooth extractions and dental implants placement is considered the major risk factor for developing medication-related osteonecrosis of the jaw (MRONJ). In this study, a patient series of MRONJ around dental implants were carefully analyzed to describe the findings and to assess the possible risk factors. Methods: Fifteen patients with peri-implant bone osteonecrosis were selected out of a group of 250 patients (6%). Patients were divided into 2 groups according to the temporal relationship. Group 1 (G1)-necrosis immediately after implant... περισσότερα »
Comparison of Two Techniques for Lateral Ridge Augmentation in Mandible With Ramus Block Graft.
The purpose of this manuscript was to assess mandibular ramus block grafts used for augmentation of mandibular posterior segments, followed by subsequent implant placement. Twenty-four human subjects in need of lateral ridge mandibular augmentation were included in the current patient series. Inclusion criteria: recipient site had at least 10-mm residual height, but less than 4.3-mm bucco-lingual dimension. Autogenous bone blocks were harvested from the mandibular ramus. In the first group ramus block was used in association with platelet-rich fibrin and in the second in association... περισσότερα »
The Effect of Crown-to-Implant Ratio on the Clinical Performance of Extra-Short Locking-Taper Implants.
Background: The aim of the present prospective 5-year study was to evaluate the influence of crown-to-implant ratio (C/I ratio) on the survival, peri-implant marginal bone loss, and complications of extra-short (6.5 mm) locking-taper implants placed in the posterior areas of the jaw. Methods: Over a 2-year period, all patients presenting with partial edentulism associated with vertical defects of the posterior alveolar ridges and sufficient bone volume to place extra-short (6.5 mm length x 5 mm diameter) implants were considered for inclusion in this study. Results: Fifty-one patien... περισσότερα »
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