Predictors and patterns of melanoma recurrence following a negative sentinel lymph node biopsy
Predictors and patterns of melanoma recurrence following a negative sentinel lymph node biopsy: [image: image]To analyse the patient demographics, tumour characteristics and follow-up data of patients with recurrence of melanoma following a negative sentinel lymph node biopsy. A retrospective review of a prospectively maintained melanoma database was conducted. Melanoma patients who had a negative sentinel lymph node were identified and we performed statistical analysis on their respective demographics, tumour histology characteristics and follow-up data. Of 164 patients studied, 40...περισσότερα »
High expression of long non-coding RNA AFAP1-AS1 predicts chemoradioresistance and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy
High expression of long non-coding RNA AFAP1-AS1 predicts chemoradioresistance and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy: To evaluate the clinical significance of lncRNAs in the resistance to cisplatin-based chemoradiotherapy in esophageal squamous cell carcinoma (ESCC). We focused on lncRNAs which were frequently reported in ESCC or were involved in chemoradiotherapy resistance. LncRNA expressions were examined in paired cisplatin-resistant and parental ESCC cell lines. Dysregulated lncRNAs were further measure... περισσότερα »
Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma
Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma: The recent development of next-generation sequencing technology for extensive mutation analysis, and beadarray technology for genome-wide DNA methylation analysis has made it possible to obtain integrated pictures of genetic and epigenetic alterations, using the same cancer samples. In this study, we aimed to characterize such a picture in esophageal squamous cell carcinomas (ESCCs). Base substitutions of 55 cancer-related genes and copy number alterations (CNAs) of 28 cancer-related genes w... περισσότερα »
Expression of GLUT-1 in oral squamous cell carcinoma
in tobacco and non-tobacco users via ScienceDirect Publication: Journal of Oral Biology and Craniofacial Research Publication date: Available online 8 January 2016 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Neha Azad, Malti Kumari Maurya, Meenakshi Kar, Madhu Mati Goel, Ajay Kumar Singh, Mala Sagar, Divya Mehrotra, Vijay Kumar BackgroundGLUTs are a family of proteins that mediate glucose transport through the membrane, expressed in head and neck squamous cell carcinoma. GLUT-1 positivity in malignant cells indicates increased proliferative activity, energy r...περισσότερα »
FGFR1 amplification and co-overexpression of c-MYC in oropharyngeal squamous cell carcinoma
FGFR1 amplification and co-overexpression of c-MYC in oropharyngeal squamous cell carcinoma: Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor of the head and neck region and the sixth leading by overall incidence [1]. Some of the most important risks for its development include alcohol and tobacco consumption [2], the latter having successfully been reduced in the last decades. However, increase in the incidence rate of certain types of HNSCC, especially oropharyngeal squamous cell carcinoma (OPSCC), because of the infection with human papilloma virus ... περισσότερα »
The way you sound affects your mood
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Researchers from France and Sweden have created a digital audio platform that can modify the emotional tone of people’s voices while they are talking, to make them sound happier, sadder or more… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1KaXpYQ via IFTTT
People who experience rage attacks have smaller «emotional brains»
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Neuroimaging studies suggest that frontolimbic regions of the brain, structures that regulate emotions, play an important role in the biology of aggressive behavior. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RzxeTT via IFTTT
Frameless Stereotactic Ommaya Reservoir Placement: Efficacy and Complication Comparison with Frame-Based Technique
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Background: Ommaya reservoirs are ventricular access devices used primarily for the administration of intrathecal antineoplastic chemotherapy. In patients with low or normal ventricular volume, stereotaxy can improve accuracy of catheter placement with minimal morbidity. Frameless stereotaxy has become an increasingly popular alternative to frame-based stereotaxy. Relative rates of successful catheter placement between these two techniques […]
Why boredom is anything but boring
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Implicated in everything from traumatic brain injury to learning ability, boredom has become extremely interesting to scientists. Nature 529 146 doi: 10.1038/529146a from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OfH88X via IFTTT
Long Noncoding RNAs in HPV-Induced Oncogenesis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Long noncoding RNAs (lncRNAs) play important roles in a wide range of oncogenic processes, including malignant transformation, epigenetic reprogramming, epithelial-to-mesenchymal transition, and metastasis development. LncRNAs induced by oncogenic viral proteins were shown to play critical roles in tumor initiation and progression. Despite this, little is known about Human papillomavirus (HPV)-induced modulation of host’s lncRNAs. In […]
Histology, Fusion Status, and Outcome in Alveolar Rhabdomyosarcoma With Low-Risk Clinical Features: A Report From the Children’s Oncology Group
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Background Distinguishing alveolar rhabdomyosarcoma (ARMS) from embryonal rhabdomyosarcoma (ERMS) is of prognostic and therapeutic importance. Criteria for classifying these entities evolved significantly from 1995 to 2013. ARMS is associated with inferior outcome; therefore, patients with alveolar histology have generally been excluded from low-risk therapy. However, patients with ARMS and low-risk stage and group (Stage 1, […]
Use of a Fitness Tracker to Promote Physical Activity in Children With Acute Lymphoblastic Leukemia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Background Children with cancer identify fatigue as a pervasive symptom, which increases during the corticosteroid pulse in acute lymphoblastic leukemia (ALL) maintenance. The FitBit® is a fitness tracker that downloads activity measurements to the Internet in real time. In this feasibility study, we explored if children who received daily FitBit® coaching for 2 weeks before […]
Systemic Chemotherapy and White Matter Integrity in Tracts Associated with Cognition Among Children With Neurofibromatosis Type 1
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Background Children with neurofibromatosis type 1 (NF1) are predisposed to both brain tumors and cognitive deficits. While changes in white matter integrity after multimodal therapy are associated with cognitive dysfunction, the effect of isolated chemotherapy in NF1 is unknown. To determine whether chemotherapy is associated with white matter microstructural changes, we examined diffusion tensor imaging […]
A Cross-Sectional Cohort Study of Cerebrovascular Disease and Late Effects After Radiation Therapy for Craniopharyngioma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Background The study objective was to describe radiation-induced vascular abnormalities, stroke prevalence, and stroke risk factors in survivors of childhood craniopharyngioma. Procedure Twenty survivors of childhood craniopharyngioma who received radiotherapy (RT) were included in the study. A clinical history, quality of life assessment, cognitive functioning assessment, magnetic resonance angiogram or computed tomography angiogram, fasting lipid […]
Pilot Study of Massage to Improve Sleep and Fatigue in Hospitalized Adolescents With Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Background Adolescents with cancer experience many troubling symptoms, including sleep disruptions that can affect mood and quality of life. Massage is a safe and popular intervention that has demonstrated efficacy in pediatric and adult patients with cancer. This study aimed to assess the feasibility of conducting a massage intervention to help with sleep in hospitalized […]
Descriptive study of Oral squamous cell carcinomas based Oral Pathology Diagnostic Service
Descriptive study of 896 Oral squamous cell carcinomas from the only University based Oral Pathology Diagnostic Service in Sri Lanka: Abstract BackgroundThe main objective of this study was to describe selected clinico-pathological characteristics of Oral Squamous Cell Carcinoma (OSCC) in Sri-Lanka. Materials & methodsThe study sample comprised of eight hundred and ninety six biopsies diagnosed as OSCC. The clinical and histopathological features were analyzed using the Chi-square test. ResultsOf the 896 biopsies, 801 were primary OSCCs, while 95 were recurrent OSCCs. Major... περισσότερα »
Patterns of differentially expressed genes in oral mucosal lesions subjected to autofluorescence
Patterns of differentially expressed genes in oral mucosal lesions subjected to autofluorescence: Abstract Objectives We aimed to elucidate the molecular pathways associated with fluorescence properties of oral potentially malignant disorders (OPMD) visualised under direct tissue autofluorescence (VELscope™). Materials and methods Forty two oral mucosal biopsies correlated with clinical fluorescence characteristics were categorised based on histopathological diagnosis. Four oral squamous cell carcinoma (OSCC), 15 oral epithelial dysplasia (OED), 9 oral lichen planus (OLP) and 14 ora...περισσότερα »
Can Superselective Intra-arterial Chemoradiotherapy replace surgery followed by radiation for advanced cancer of tongue and floor of mouth?
Can Superselective Intra-arterial Chemoradiotherapy replace surgery followed by radiation for advanced cancer of tongue and floor of mouth? via Oral and Maxillofacial Surgery Publication date: Available online 8 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Wataru Kobayashi, Kosei Kukobota, Ryohei Ito, Hirotaka Sakaki, Hirosi Nakagawa, Beng Gwan Teh PurposeThe purpose of this study was to compare quality of life (QoL) and survival rate after surgery with and without radiotherapy versus superselective intra-arterial chemoradiotherapy (SSIACRT) for advanced c... περισσότερα »
Hypoxia promotes the invasion and metastasis of laryngeal cancer cells via EMT
Hypoxia promotes the invasion and metastasis of laryngeal cancer cells via EMT: AbstractThe purpose of this study is to explore the role of hypoxia on the invasion and metastasis of laryngeal carcinoma. The invasion and migration ability of laryngeal cancer SCC10A cell was detected by transwell assay. Western blot was applied to analyze the expression of EMT-related proteins. Fifty-seven samples from postoperative patients with laryngeal cancer were collected to study. Immunohistochemistry was used to examine the expression of GLUT-1 and EMT-related proteins (Vim, E-cad, N-cad) in ...περισσότερα »
Prognostic significance of cytoplasmic p27 in oral squamous cell carcinoma
Prognostic significance of cytoplasmic p27 in oral squamous cell carcinoma: Objective p27 is a cell cycle-dependent kinase inhibitor whose presence in nucleus is associated with good prognosis. Recent studies propose that when localized to cytoplasm, it functions as an oncogene and confers a poorer prognosis. This study aimed at analysing the subcellular localization of p27 and its prognostic significance in oral squamous cell carcinomas (OSCCs). Methods Immunohistochemistry for p27 was carried out on 60 cases of OSCC (30 cases each of those with lymph node metastasis [LN+ve SCC] and... περισσότερα »
Gemcitabine-Based Chemoradiation in the Treatment of Locally Advanced Head and Neck Cancer: Systematic Review of Literature and Meta-Analysis
Gemcitabine-Based Chemoradiation in the Treatment of Locally Advanced Head and Neck Cancer: Systematic Review of Literature and Meta-Analysis: Background. Platinum-based concurrent chemoradiation (CCRT) improves locoregional control and overall survival of locoregionally advanced (LA) squamous cell carcinoma of the head and neck (SCCHN) when compared to radiotherapy alone, but this approach is hampered by significant toxicity. Therefore, alternative ways to enhance the radiation effects are worth investigating. Gemcitabine (2',2'-difluorodeoxycytidine), in addition to its activity ...περισσότερα »
Perspectives in chemosensitivity and chemoresistance assays and their implementation in head and neck cancer
Perspectives in chemosensitivity and chemoresistance assays and their implementation in head and neck cancer: AbstractTherapeutic options for patients with head and neck squamous cell carcinoma include surgery, radiation and chemotherapy. The latter plays a major role in the treatment selection of recurrent, metastatic or therapy resistant tumours, these being some of the major challenges in head and neck oncology. For these patients, chemosensitivity and chemoresistance assays would be paramount to identify their individual therapy options. In this review, seven common assays will... περισσότερα »
HNC : Differences in health related quality of life in the randomised ARTSCAN study; accelerated vs. conventional radiotherapy for head and neck cancer. A five year follow up
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Differences in health related quality of life in the randomised ARTSCAN study; accelerated vs. conventional radiotherapy for head and neck cancer. A five year follow up: Health related quality of life (HRQoL) was assessed in the randomised, prospective ARTSCAN study comparing conventional radiotherapy (CF) with accelerated radiotherapy (AF) for head and neck cancer. from #Med […]
Extranodal Natural Killer/T-Cell Lymphoma of the Nasal Type with Skin Metastases
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Extranodal Natural Killer/T-Cell Lymphoma of the Nasal Type with Skin Metastases: Extranodal natural killer/T-cell lymphoma (ENKL) of the nasal type is a rare, clinically aggressive disease. ENKL of the nasal type is often localized in the upper aerodigestive tract, including the nasal cavity, nasopharynx, paranasal sinuses, tonsils, hypopharynx and larynx, and usually presents as stage […]
Carcinogenesis of nasopharyngeal carcinoma: The association of salivary gland morphogenesis with an evolutionary variant of the human ectodysplasin receptor gene (EDAR), EDARV370A
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Carcinogenesis of nasopharyngeal carcinoma: an alternate hypothetical mechanism: Abstract Current proposed mechanisms implicate both early and latent Epstein–Barr virus (EBV) infection in the carcinogenic cascade, whereas epidemiological studies have always associated nasopharyngeal carcinoma (NPC) with early childhood EBV infection and with chronic ear, nose, and sinus conditions. Moreover, most patients with NPC present with IgA […]
Carcinogenesis of nasopharyngeal carcinoma: an alternate hypothetical mechanism
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Carcinogenesis of nasopharyngeal carcinoma: an alternate hypothetical mechanism: Abstract Current proposed mechanisms implicate both early and latent Epstein–Barr virus (EBV) infection in the carcinogenic cascade, whereas epidemiological studies have always associated nasopharyngeal carcinoma (NPC) with early childhood EBV infection and with chronic ear, nose, and sinus conditions. Moreover, most patients with NPC present with IgA […]
Locoregionally advanced nasopharyngeal carcinoma: Neoadjuvant chemotherapy plus intensity-modulated radiotherapy versus concurrent chemoradiotherapy plus adjuvant chemotherapy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Neoadjuvant chemotherapy plus intensity-modulated radiotherapy versus concurrent chemoradiotherapy plus adjuvant chemotherapy for the treatment of locoregionally advanced nasopharyngeal carcinoma: a retrospective controlled study: Abstract Background In the era of intensity-modulated radiotherapy (IMRT), the role of neoadjuvant chemotherapy (NAC) for locoregionally advanced nasopharyngeal carcinoma (NPC) is under-evaluated. The aim of this study was to compare the […]
Movers And Packers Mumbai @ http://ift.tt/1mSvJT7
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Expert Packers And Movers Produce Ones Moving Method Very easy And Easy Moving is certainly not a simple activity to execute. It requires time And superior preparing. While it concerns create changing, it leads to many undesired difficulties, but persons must contend in place. Packaging, travel… from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1SLOa8C via […]
HNC : Effect of polypharmacy and potentially inappropriate medications on treatment and posttreatment courses in elderly patients with head and neck cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Effect of polypharmacy and potentially inappropriate medications on treatment and posttreatment courses in elderly patients with head and neck cancer: Abstract Purpose The use of excessive and inappropriate medications is a common problem in elderly populations. The use of polypharmacy (PP) and potentially inappropriate medication (PIM) may affect treatment-related morbidities in elderly cancer patients, which […]
Identification of novel NRAGE involved in the radioresistance of esophageal cancer cells
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Identification of novel NRAGE involved in the radioresistance of esophageal cancer cells: Abstract Radiotherapy (RT) is one main method for the treatment of esophageal squamous cell carcinoma (ESCC), and the radioresistance is the predominant cause of patients with local recurrence. The previous results of gene microarray and subsequent verification showed that NRAGE might be involved […]
Diagnostic significance of elevated expression of HBME-1 in papillary thyroid carcinoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Diagnostic significance of elevated expression of HBME-1 in papillary thyroid carcinoma: Abstract This study examined the association between hector battifora mesothelial antigen-1 (HBME-1) expression and papillary thyroid carcinoma (PTC). A total of 206 patients were enrolled in the current study including 96 PTC patients and 110 patients with benign thyroid nodules (BTN). Immunohistochemistry (Envision) were […]
A Novel Enzyme-Targeting Radiosensitizer (New KORTUC) Using a Gelatin-Based Hydrogel Instead of a Sodium Hyaluronate
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Cancers, Vol. 8, Pages 10: Development of a Novel Enzyme-Targeting Radiosensitizer (New KORTUC) Using a Gelatin-Based Hydrogel Instead of a Sodium Hyaluronate: We recently developed Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas (KORTUC) as a strategy to increase intratumoral oxygen concentrations and degrade antioxidant enzymes such as peroxidase and catalase. We then developed KORTUC II, which […]
In vivo rectal wall measurements during HDR prostate brachytherapy with MOSkin dosimeters integrated on a trans-rectal US probe: Comparison with planned and reconstructed doses
Publication date: Available online 12 January 2016 *Source:*Radiotherapy and Oncology Author(s): Mauro Carrara, Chiara Tenconi, Giulio Rossi, Marta Borroni, Annamaria Cerrotta, Simone Grisotto, Davide Cusumano, Brigida Pappalardi, Dean Cutajar, Marco Petasecca, Michael Lerch, Grazia Gambarini, Carlo Fallai, Anatoly Rosenfeld, Emanuele Pignoli Background and purposeTo study if MOSkin detectors coupled to a trans-rectal ultrasound (TRUS) probe may be used for in vivo dosimetry on the rectal wall surface during US-based HDR prostate brachytherapy and to quantify possible discrepancies ... περισσότερα »
Clinical, cytogenetic, and molecular outcomes in a series of 66 patients with Pierre Robin sequence and literature review: 22q11.2 deletion is less common than other chromosomal anomalies
Pierre Robin sequence (PRS) is an important craniofacial anomaly that can be seen as an isolated finding or manifestation of multiple syndromes. 22q11.2 deletion and Stickler syndrome are cited as the two most common conditions associated with PRS, but their frequencies are debated. We performed a retrospective study of 66 patients with PRS and reviewed their genetic testing, diagnoses, and clinical findings. The case series is complemented by a comprehensive literature review of the nature and frequency of genetic diagnosis in PRS. In our cohort 65% of patients had associated an... περισσότερα »
Frameless Stereotactic Ommaya Reservoir Placement: Efficacy and Complication Comparison with Frame-Based Technique
*Background:* Ommaya reservoirs are ventricular access devices used primarily for the administration of intrathecal antineoplastic chemotherapy. In patients with low or normal ventricular volume, stereotaxy can improve accuracy of catheter placement with minimal morbidity. Frameless stereotaxy has become an increasingly popular alternative to frame-based stereotaxy. Relative rates of successful catheter placement between these two techniques are not described in the literature. *Objectives:* To compare a large series of frameless to frame-based stereotactic catheter placements for O...περισσότερα »
Haplosufficiency of PAX3 for melanoma development in Tyr: NRASQ61K; Cdkn2a−/− mice allows identification and sorting of melanoma cells using a Pax3GFP reporter allele
Haplosufficiency of PAX3 for melanoma development in Tyr: NRASQ61K; Cdkn2a−/− mice allows identification and sorting of melanoma cells using a Pax3GFP reporter allele: [image: image]The role of the Pax3 gene in embryonic development of pigment cells is well characterized. By contrast, the function of Pax3 in melanoma development is controversial. Indeed, data obtained from cultured cells suggest that PAX3 may contribute to melanomagenesis. PAX3 is found to be overexpressed in melanomas and also in nevi compared with normal skin samples. Pax3 homozygous loss of function is embryonic ... περισσότερα »
Skin self-examination behaviors among individuals diagnosed with melanoma
Skin self-examination behaviors among individuals diagnosed with melanoma: [image: image] Many melanoma patients do not regularly perform thorough skin self-examinations. We examined the extent to which melanoma patients conduct thorough skin self-examination, how they perform skin self-examination, and their related knowledge and self-efficacy. A sample of 176 individuals (61.5% response rate) diagnosed with primary pathologic stage 0–III cutaneous malignant melanoma at a single cancer center completed a written or telephone survey regarding their skin self-examination behaviors ... περισσότερα »
Palliative Care Checklist
Impact of a Palliative Care Checklist on Clinical Documentation [Focus on Quality]: Purpose Checklists are used in many different settings for the purpose of standardization and reduction of preventable errors in practice. Our group sought to determine whether a palliative care checklist (PCC) would improve the clinical documentation of key patient information. Methods An initial review of 110 randomly selected medical records dictated by 10 physicians was performed. The authors identified portions of the dictated medical records that were included regularly, as well as those that ... περισσότερα »
Frameless LINAC based stereotactic radiotherapy to brain metastasis resection cavity without whole brain radiotherapy
: A systematic review via Practical Radiation Oncology *Source:*Practical Radiation Oncology Author(s): Orit Kaidar-Person, Timothy M. Zagar, Matthew Ewend, Tzahala Tzuk-Shina, Lawrence B. Marks The aim of this systematic review was to summarize the findings from the published data of frameless stereotactic radiotherapy to the resection cavity delivered with non- robotic – linear accelerator in patients with brain metastases.MethodsThe studies cited in this systematic review were identified through a search of the PubMed database, using the search terms: "stereotactic [Title/Abstrac...περισσότερα »
Survivin Modulates Squamous Cell Carcinoma-Derived Stem-Like Cell Proliferation, Viability and Tumor Formation in Vivo
IJMS, Vol. 17, Pages 89: Survivin Modulates Squamous Cell Carcinoma-Derived Stem-Like Cell Proliferation, Viability and Tumor Formation in Vivo: Squamous Cell Carcinoma-derived Stem-like Cells (SCC-SC) originate from alterations in keratinocyte stem cells (KSC) gene expression and sustain tumor development, invasion and recurrence. Since survivin, a KSC marker, is highly expressed in SCC-SC, we evaluate its role in SCC-SC cell growth and SCC models. Survivin silencing by siRNA decreases clonal growth of SCC keratinocytes and viability of total, rapidly adhering (RAD) and non-RAD (NR... περισσότερα »
Haplosufficiency of PAX3 for melanoma development in Tyr: NRASQ61K; Cdkn2a−/− mice allows identification and sorting of melanoma cells using a Pax3GFP reporter allele
Haplosufficiency of PAX3 for melanoma development in Tyr: NRASQ61K; Cdkn2a−/− mice allows identification and sorting of melanoma cells using a Pax3GFP reporter allele: [image: image]The role of the Pax3 gene in embryonic development of pigment cells is well characterized. By contrast, the function of Pax3 in melanoma development is controversial. Indeed, data obtained from cultured cells suggest that PAX3 may contribute to melanomagenesis. PAX3 is found to be overexpressed in melanomas and also in nevi compared with normal skin samples. Pax3 homozygous loss of function is embryonic ... περισσότερα »
Skin self-examination behaviors among individuals diagnosed with melanoma
Skin self-examination behaviors among individuals diagnosed with melanoma: [image: image] Many melanoma patients do not regularly perform thorough skin self-examinations. We examined the extent to which melanoma patients conduct thorough skin self-examination, how they perform skin self-examination, and their related knowledge and self-efficacy. A sample of 176 individuals (61.5% response rate) diagnosed with primary pathologic stage 0–III cutaneous malignant melanoma at a single cancer center completed a written or telephone survey regarding their skin self-examination behaviors a... περισσότερα »
Clinical, cytogenetic, and molecular outcomes in a series of 66 patients with Pierre Robin sequence and literature review: 22q11.2 deletion is less common than other chromosomal anomalies
Pierre Robin sequence (PRS) is an important craniofacial anomaly that can be seen as an isolated finding or manifestation of multiple syndromes. 22q11.2 deletion and Stickler syndrome are cited as the two most common conditions associated with PRS, but their frequencies are debated. We performed a retrospective study of 66 patients with PRS and reviewed their genetic testing, diagnoses, and clinical findings. The case series is complemented by a comprehensive literature review of the nature and frequency of genetic diagnosis in PRS. In our cohort 65% of patients had associated an... περισσότερα »
Thoracolumbar spinal cord tolerance to high dose conformal proton–photon radiation therapy
Publication date: Available online 11 January 2016 *Source:*Radiotherapy and Oncology Author(s): Varun K. Chowdhry, Li Liu, Saveli Goldberg, Judith A. Adams, Karen Bernstein, Norbert J. Liebsch, Andrzej Niemierko, Yen-Lin Chen, Thomas F. DeLaney PurposeTo evaluate and understand the tolerance of the thoracolumbar spinal cord using equivalent uniform dose (EUD) and dose volume histogram (DVH) analysis after combined high dose photon–proton radiotherapy.Materials and methodsA total of 68 patients were identified as having high dose radiotherapy, ⩾5900cGy (RBE) in the region of the tho...περισσότερα »
Delaying standard combined chemoradiotherapy after surgical resection does not impact survival in newly diagnosed glioblastoma patients
Publication date: Available online 11 January 2016 *Source:*Radiotherapy and Oncology Author(s): Guillaume Louvel, Philippe Metellus, Georges Noel, Sophie Peeters, Jacques Guyotat, Julien Duntze, Pierre-Jean Le Reste, Phong Dam Hieu, Thierry Faillot, Fabien Litre, Nicolas Desse, Antoine Petit, Evelyne Emery, Jimmy Voirin, Johann Peltier, François Caire, Jean-Rodolphe Vignes, Jean-Luc Barat, Olivier Langlois, Philippe Menei, Sarah N. Dumont, Marc Zanello, Edouard Dezamis, Frédéric Dhermain, Johan Pallud BackgroundTo assess the influence of the time interval between surgical resection... περισσότερα »
In vivo rectal wall measurements during HDR prostate brachytherapy with MOSkin dosimeters integrated on a trans-rectal US probe: Comparison with planned and reconstructed doses
Publication date: Available online 12 January 2016 *Source:*Radiotherapy and Oncology Author(s): Mauro Carrara, Chiara Tenconi, Giulio Rossi, Marta Borroni, Annamaria Cerrotta, Simone Grisotto, Davide Cusumano, Brigida Pappalardi, Dean Cutajar, Marco Petasecca, Michael Lerch, Grazia Gambarini, Carlo Fallai, Anatoly Rosenfeld, Emanuele Pignoli Background and purposeTo study if MOSkin detectors coupled to a trans-rectal ultrasound (TRUS) probe may be used for in vivo dosimetry on the rectal wall surface during US-based HDR prostate brachytherapy and to quantify possible discrepancies ... περισσότερα »
Frameless Stereotactic Ommaya Reservoir Placement: Efficacy and Complication Comparison with Frame-Based Technique
*Background:* Ommaya reservoirs are ventricular access devices used primarily for the administration of intrathecal antineoplastic chemotherapy. In patients with low or normal ventricular volume, stereotaxy can improve accuracy of catheter placement with minimal morbidity. Frameless stereotaxy has become an increasingly popular alternative to frame-based stereotaxy. Relative rates of successful catheter placement between these two techniques are not described in the literature. *Objectives:* To compare a large series of frameless to frame-based stereotactic catheter placements for O...περισσότερα »
Palliative Care Checklist
Impact of a Palliative Care Checklist on Clinical Documentation [Focus on Quality]: Purpose Checklists are used in many different settings for the purpose of standardization and reduction of preventable errors in practice. Our group sought to determine whether a palliative care checklist (PCC) would improve the clinical documentation of key patient information. Methods An initial review of 110 randomly selected medical records dictated by 10 physicians was performed. The authors identified portions of the dictated medical records that were included regularly, as well as those that ... περισσότερα »
Frameless LINAC based stereotactic radiotherapy to brain metastasis resection cavity without whole brain radiotherapy
: A systematic review via Practical Radiation Oncology *Source:*Practical Radiation Oncology Author(s): Orit Kaidar-Person, Timothy M. Zagar, Matthew Ewend, Tzahala Tzuk-Shina, Lawrence B. Marks The aim of this systematic review was to summarize the findings from the published data of frameless stereotactic radiotherapy to the resection cavity delivered with non- robotic – linear accelerator in patients with brain metastases.MethodsThe studies cited in this systematic review were identified through a search of the PubMed database, using the search terms: “stereotactic [Title/Abstract...περισσότερα »
HNC : Differences in health related quality of life in the randomised ARTSCAN study; accelerated vs. conventional radiotherapy for head and neck cancer. A five year follow up
Differences in health related quality of life in the randomised ARTSCAN study; accelerated vs. conventional radiotherapy for head and neck cancer. A five year follow up: [image: gr1.sml] Health related quality of life (HRQoL) was assessed in the randomised, prospective ARTSCAN study comparing conventional radiotherapy (CF) with accelerated radiotherapy (AF) for head and neck cancer.
Extranodal Natural Killer/T-Cell Lymphoma of the Nasal Type with Skin Metastases
Extranodal Natural Killer/T-Cell Lymphoma of the Nasal Type with Skin Metastases: Extranodal natural killer/T-cell lymphoma (ENKL) of the nasal type is a rare, clinically aggressive disease. ENKL of the nasal type is often localized in the upper aerodigestive tract, including the nasal cavity, nasopharynx, paranasal sinuses, tonsils, hypopharynx and larynx, and usually presents as stage I/II. Extranasal involvement can occur, and a common site of extranasal involvement or metastatic disease includes the skin. Identifying skin metastases is important for the appropriate staging and t... περισσότερα »
Carcinogenesis of nasopharyngeal carcinoma: The association of salivary gland morphogenesis with an evolutionary variant of the human ectodysplasin receptor gene (EDAR), EDARV370A
Carcinogenesis of nasopharyngeal carcinoma: an alternate hypothetical mechanism: AbstractCurrent proposed mechanisms implicate both early and latent Epstein–Barr virus (EBV) infection in the carcinogenic cascade, whereas epidemiological studies have always associated nasopharyngeal carcinoma (NPC) with early childhood EBV infection and with chronic ear, nose, and sinus conditions. Moreover, most patients with NPC present with IgA antibody titers to EBV capsid antigen (VCA-IgA), which can precede actual tumor presentation by several years. If early childhood EBV infection indeed co... περισσότερα »
Carcinogenesis of nasopharyngeal carcinoma: an alternate hypothetical mechanism
Carcinogenesis of nasopharyngeal carcinoma: an alternate hypothetical mechanism: AbstractCurrent proposed mechanisms implicate both early and latent Epstein–Barr virus (EBV) infection in the carcinogenic cascade, whereas epidemiological studies have always associated nasopharyngeal carcinoma (NPC) with early childhood EBV infection and with chronic ear, nose, and sinus conditions. Moreover, most patients with NPC present with IgA antibody titers to EBV capsid antigen (VCA-IgA), which can precede actual tumor presentation by several years. If early childhood EBV infection indeed co... περισσότερα »
The Communication Supports Inventory-Children & Youth (CSI-CY), a new instrument based on the ICF-CY.
*The Communication Supports Inventory-Children & Youth (CSI-CY), a new instrument based on the ICF-CY.* Disabil Rehabil. 2016 Jan 10;:1-9 Authors: Rowland C, Fried-Oken M, Bowser G, Granlund M, Lollar D, Phelps R, Simeonsson RJ, Steiner SA Abstract PURPOSE: Two studies are presented that evaluated the Communication Supports Inventory-Children & Youth (CSI-CY), an instrument designed to facilitate the development of communication-related educational goals for students with complex communication needs (CCN). The CSI-CY incorporates a code set based on the ICF-CY. The studies were ... περισσότερα »
A single-group pilot feasibility study of cognitive behavioural therapy in people with multiple sclerosis with depressive symptoms.
*A single-group pilot feasibility study of cognitive behavioural therapy in people with multiple sclerosis with depressive symptoms.* Disabil Rehabil. 2016 Jan 10;:1-9 Authors: Chruzander C, Gottberg K, Ytterberg C, Backenroth G, Fredrikson S, Widén Holmqvist L, Johansson S Abstract Purpose The aims were to evaluate (a) the feasibility of face-to-face cognitive behavioural therapy (CBT) in people with MS (PwMS) with depressive symptoms; (b) the feasibility of methods and measurements used; and (c) the outcome of the intervention before the conducting of an equivalence study of c...περισσότερα »
Spatial neglect in stroke patients after discharge from rehabilitation to own home: a mixed method study.
*Spatial neglect in stroke patients after discharge from rehabilitation to own home: a mixed method study.* Disabil Rehabil. 2016 Jan 10;:1-16 Authors: Klinke ME, Hjaltason H, Hafsteinsdóttir TB, Jónsdóttir H Abstract Purpose To explore the usefulness of conventional tests for assessing spatial neglect and contrast these tests with daily challenges encountered by patients after discharge from rehabilitation to home. Methods A mixed method prospective study of 15 patients with neglect after a right hemisphere stroke, <1 month after discharge to home. Data were obtained from: (1) ... περισσότερα »
Hip external rotator exercise contributes to improving physical functions in the early stage after total hip arthroplasty using an anterolateral approach: a randomized controlled trial.
*Hip external rotator exercise contributes to improving physical functions in the early stage after total hip arthroplasty using an anterolateral approach: a randomized controlled trial.* Disabil Rehabil. 2016 Jan 10;:1-6 Authors: Nankaku M, Ikeguchi R, Goto K, So K, Kuroda Y, Matsuda S Abstract Purpose The purpose of this study was to investigate the effects of an exercise program focusing on hip external rotator muscle on physical recovery in the early post-operative period of total hip arthroplasty (THA). Methods Patients who underwent THA were randomized to an exercise group... περισσότερα »
Mapping two measures to the International Classification Of Functioning, Disability and Health and the brief ICF core set for spinal cord injury in the post-acute context.
*Mapping two measures to the International Classification Of Functioning, Disability and Health and the brief ICF core set for spinal cord injury in the post-acute context.* Disabil Rehabil. 2016 Jan 9;:1-9 Authors: Joseph C, Phillips J, Wahman K, Nilsson Wikmar L Abstract OBJECTIVE: To evaluate the extent to which the rehabilitation outcome levels (ROL) and the spinal cord independence measure (SCIM) III could be mapped to the International Classification of Functioning, Disability and Health (ICF) and the brief core set for spinal cord injury (SCI) in the post-acute context. M... περισσότερα »
Ethics teaching in rehabilitation: results of a pan-Canadian workshop with occupational and physical therapy educators.
*Ethics teaching in rehabilitation: results of a pan-Canadian workshop with occupational and physical therapy educators.* Disabil Rehabil. 2016 Jan 10;:1-11 Authors: Hudon A, Perreault K, Laliberté M, Desrochers P, Williams-Jones B, Ehrmann Feldman D, Hunt M, Durocher E, Mazer B Abstract Purpose Ethical practice is an essential competency for occupational and physical therapists. However, rehabilitation educators have few points of reference for choosing appropriate pedagogical and evaluation methods related to ethics. The objectives of this study were to: (1) identify priority ... περισσότερα »
Molecular basis of ALS and FTD: implications for translational studies / Molekularna osnova ALS-a i FTD-a: implikacije za translacijska istraživanja.
*Molecular basis of ALS and FTD: implications for translational studies / Molekularna osnova ALS-a i FTD-a: implikacije za translacijska istraživanja.* Arh Hig Rada Toksikol. 2015 Dec 1;66(4):285-290 Authors: Liščić RM Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders, related by signs of deteriorating motor and cognitive functions, and short survival. The cause is unknown and no effective treatment currently exists. For ALS, there is only a drug Riluzole and a promising substance arimoclomol. The overlap between ALS a... περισσότερα »
Rational search for genes in familial cortical myoclonic tremor with epilepsy, clues from recent advances.
*Rational search for genes in familial cortical myoclonic tremor with epilepsy, clues from recent advances.* Seizure. 2015 Dec 15;34:83-89 Authors: Cen ZD, Xie F, Xiao JF, Luo W Abstract Familial cortical myoclonic tremor with epilepsy (FCMTE) is an autosomal dominant epilepsy syndrome with considerable clinical and genetic heterogeneity. The most important clinical manifestations include adult onset, cortical myoclonic tremor, with or without epileptic seizures. Of the four loci reported, which included 8q24 (FCMTE1), 2p11.1-q12.2 (FCMTE2), 5p15.31-p15.1 (FCMTE3), and 3q26.32-3... περισσότερα »
Inhibiting amyloid β-protein assembly: Size-activity relationships among grape seed-derived polyphenols.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Inhibiting amyloid β-protein assembly: Size-activity relationships among grape seed-derived polyphenols.* J Neurochem. 2015 Oct;135(2):416-30 Authors: Hayden EY, Yamin G, Beroukhim S, Chen B, Kibalchenko M, Jiang L, Ho L, Wang J, Pasinetti GM, Teplow DB Abstract Epidemiological evidence that red wine consumption negatively correlates with risk of Alzheimer's disease has led to experimental studies demonstrating that grape seed extracts inhibit the aggregation and oligomerization of Aβ in vitro and ameliorate neur...περισσότερα »
The Study and Consequences of Repetitive Traumatic Brain Injury. Introduction.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *The Study and Consequences of Repetitive Traumatic Brain Injury. Introduction.* Brain Pathol. 2015 May;25(3):287-8 Authors: Smith C PMID: 25904044 [PubMed - indexed for MEDLINE] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1ON4yEg via IFTTT
Locoregionally advanced nasopharyngeal carcinoma: Neoadjuvant chemotherapy plus intensity-modulated radiotherapy versus concurrent chemoradiotherapy plus adjuvant chemotherapy
Neoadjuvant chemotherapy plus intensity-modulated radiotherapy versus concurrent chemoradiotherapy plus adjuvant chemotherapy for the treatment of locoregionally advanced nasopharyngeal carcinoma: a retrospective controlled study: Abstract BackgroundIn the era of intensity-modulated radiotherapy (IMRT), the role of neoadjuvant chemotherapy (NAC) for locoregionally advanced nasopharyngeal carcinoma (NPC) is under-evaluated. The aim of this study was to compare the efficacy of NAC plus IMRT and concurrent chemoradiotherapy (CCRT) plus adjuvant chemotherapy (AC) on locoregionally ad... περισσότερα »
Identification of novel NRAGE involved in the radioresistance of esophageal cancer cells
Identification of novel NRAGE involved in the radioresistance of esophageal cancer cells: AbstractRadiotherapy (RT) is one main method for the treatment of esophageal squamous cell carcinoma (ESCC), and the radioresistance is the predominant cause of patients with local recurrence. The previous results of gene microarray and subsequent verification showed that NRAGE might be involved in radiation resistance of ESCC cells. In this study, we reestablished human esophageal carcinoma radioresistant cell lines TE13R120 and ECA109R60 with gradient dose irradiation as previously reported,...περισσότερα »
Diagnostic significance of elevated expression of HBME-1 in papillary thyroid carcinoma
Diagnostic significance of elevated expression of HBME-1 in papillary thyroid carcinoma: AbstractThis study examined the association between hector battifora mesothelial antigen-1 (HBME-1) expression and papillary thyroid carcinoma (PTC). A total of 206 patients were enrolled in the current study including 96 PTC patients and 110 patients with benign thyroid nodules (BTN). Immunohistochemistry (Envision) were performed to assess the expression of HBME-1. Receiver operating characteristic curve (ROC) curves were applied to evaluate the diagnostic tumor node metastasis (TNM) value of...περισσότερα »
HNC : Effect of polypharmacy and potentially inappropriate medications on treatment and posttreatment courses in elderly patients with head and neck cancer
Effect of polypharmacy and potentially inappropriate medications on treatment and posttreatment courses in elderly patients with head and neck cancer: Abstract PurposeThe use of excessive and inappropriate medications is a common problem in elderly populations. The use of polypharmacy (PP) and potentially inappropriate medication (PIM) may affect treatment-related morbidities in elderly cancer patients, which has rarely been studied in patients with head and neck cancer (HNC). Here, we evaluate the effects of PP and PIM on treatment and posttreatment courses in elderly HNC patient... περισσότερα »
A Novel Enzyme-Targeting Radiosensitizer (New KORTUC) Using a Gelatin-Based Hydrogel Instead of a Sodium Hyaluronate
Cancers, Vol. 8, Pages 10: Development of a Novel Enzyme-Targeting Radiosensitizer (New KORTUC) Using a Gelatin-Based Hydrogel Instead of a Sodium Hyaluronate: We recently developed Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas (KORTUC) as a strategy to increase intratumoral oxygen concentrations and degrade antioxidant enzymes such as peroxidase and catalase. We then developed KORTUC II, which uses sodium hyaluronate containing hydrogen peroxide as a radiosensitizer. KORTUC II requires twice-weekly administration to sustain its effects, but decreasing the frequency of ... περισσότερα »
Preclinical Activity of the Vascular Disrupting Agent OXi4503 against Head and Neck Cancer
Cancers, Vol. 8, Pages 11: Preclinical Activity of the Vascular Disrupting Agent OXi4503 against Head and Neck Cancer: Vascular disrupting agents (VDAs) represent a relatively distinct class of agents that target established blood vessels in tumors. In this study, we examined the preclinical activity of the second-generation VDA OXi4503 against human head and neck squamous cell carcinoma (HNSCC). Studies were performed in subcutaneous and orthotopic FaDu-luc HNSCC xenografts established in immunodeficient mice. In the subcutaneous model, bioluminescence imaging (BLI) along with tumo... περισσότερα »
Radiation therapy in non-melanoma cancers, lymphomas and sarcomas of the skin
Role of radiation therapy in non-melanoma cancers, lymphomas and sarcomas of the skin: systematic review and best practice in 2015 via Critical Reviews in Oncology/Hematology (open access) Publication date: Available online 11 January 2016 *Source:*Critical Reviews in Oncology/Hematology Author(s): Magali Fort, Saada Guet, Laurianne Colson-Durand, Claire Auzolle, Yazid Belkacemi Radiotherapy has been used for the treatment of skin cancers since very early after the discovery of x-rays. Indications for radiotherapy in non-melanoma cancers are controversial, and are usually decided accord... περισσότερα »
Radioiodine Refractory Differentiated Thyroid Carcinomas
Outcomes and Prognostic Factors in Radioiodine Refractory Differentiated Thyroid Carcinomas: Background. Outcomes vary among patients with radioiodine refractory (RR) differentiated thyroid cancer (DTC). The prognostic factors for survival are not well-known, resulting in difficulty in selecting patients for new targeted therapies. We assessed overall survival (OS) and cancer-specific survival (CSS) from RR-DTC to identify prognostic factors associated with survival. Patients and Methods. The data on all cases of metastatic RR-DTC treated in our center from 1990 to 2011 were retro... περισσότερα »
Gemcitabine-Based Chemoradiation in the Treatment of Locally Advanced Head and Neck Cancer: Systematic Review of Literature and Meta-Analysis
Gemcitabine-Based Chemoradiation in the Treatment of Locally Advanced Head and Neck Cancer: Systematic Review of Literature and Meta-Analysis: Background. Platinum-based concurrent chemoradiation (CCRT) improves locoregional control and overall survival of locoregionally advanced (LA) squamous cell carcinoma of the head and neck (SCCHN) when compared to radiotherapy alone, but this approach is hampered by significant toxicity. Therefore, alternative ways to enhance the radiation effects are worth investigating. Gemcitabine (2',2'-difluorodeoxycytidine), in addition to its activity ...περισσότερα »
Circulating Tumor Cells, DNA, and mRNA: Potential for Clinical Utility in Patients With Melanoma
Circulating Tumor Cells, DNA, and mRNA: Potential for Clinical Utility in Patients With Melanoma: Circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and messenger RNA (mRNA), collectively termed circulating tumor products (CTPs), represent areas of immense interest from scientists’ and clinicians’ perspectives. In melanoma, CTP analysis may have clinical utility in many areas, from screening and diagnosis to clinical decision-making aids, as surveillance biomarkers or sources of real-time genetic or molecular characterization. In addition, CTP analysis can be useful in... περισσότερα »
Applying the COM-B behaviour model and behaviour change wheel to develop an intervention to improve hearing-aid use in adult auditory rehabilitation
10.3109/14992027.2015.1120894<br>Fiona Barker from #Audiology via ola Kala on Inoreader http://ift.tt/1OYOu4d via IFTTT
Understanding the psychosocial experiences of adults with mild-moderate hearing loss: An application of Leventhal’s self-regulatory model
10.3109/14992027.2015.1117663<br>Eithne Heffernan from #Audiology via ola Kala on Inoreader http://ift.tt/1OYOwsI via IFTTT
A demonstrated positive effect of a hearing conservation program in the Swedish armed forces
10.3109/14992027.2015.1117662<br>Per Muhr from #Audiology via ola Kala on Inoreader http://ift.tt/1OYOtNO via IFTTT
The Spinal Instability Neoplastic Score
The Effect of Introducing the Spinal Instability Neoplastic Score in Routine Clinical Practice for Patients With Spinal Metastases: Background. Stable spinal metastases are effectively treated with radiotherapy, whereas unstable spinal metastases often need surgical fixation followed by radiotherapy for local control. The Spinal Instability Neoplastic Score (SINS) was developed as a tool to assess spinal neoplastic related instability with the goal of helping to guide referrals among oncology specialists. We compare the average degree of spinal instability between patients with spin... περισσότερα »
Lymphomatoid papulosis (LyP) is classified as an indolent cutaneous lymphoma
Frequency and Risk Factors for Associated Lymphomas in Patients With Lymphomatoid Papulosis: Background. Lymphomatoid papulosis (LyP) is classified as an indolent cutaneous lymphoma, but outcome dramatically worsens if LyP is associated with lymphoma. The frequency of this association remains unclear in the literature. Here, we assess the frequency and risk factors of association between LyP and another lymphoma in an 11-year retrospective study conducted in 8 dermatology departments belonging to the French Study Group on Cutaneous Lymphoma (FSGCL). Patients and Methods. Patients ... περισσότερα »
Neuroendocrine carcinoma of the breast (NECB)
Neuroendocrine Carcinoma of the Breast: Current Evidence and Future Perspectives: Neuroendocrine carcinoma of the breast is considered a rare entity, and for this reason there are no data from prospective clinical trials on its optimal management. Early stage tumors are usually treated with the same strategy used for the other types of invasive breast cancer. Anthracycline- and taxane-based regimens represent the most frequently administered chemotherapy in neoadjuvant and adjuvant setting, as well as for metastatic disease, although combinations of platinum compounds and etoposide... περισσότερα »
The immunomodulatory drugs (IMiDs) thalidomide and lenalidomide
Delayed Efficacy After Treatment With Lenalidomide or Thalidomide in Patients With Mucosa-Associated Lymphoid Tissue Lymphoma: Background. The immunomodulatory drugs (IMiDs) thalidomide and lenalidomide have both been tested for treatment of mucosa-associated lymphoid tissue (MALT) lymphoma, with lenalidomide, in particular, showing promising activity. However, long-term results are missing. Because of the late-onset remissions registered in individual patients, we have systemically analyzed the patients treated with IMiDs at our institution for long-term results. Methods. Within t...περισσότερα »
Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
Delayed Efficacy After Treatment With Lenalidomide or Thalidomide in Patients With Mucosa-Associated Lymphoid Tissue Lymphoma: Background. The immunomodulatory drugs (IMiDs) thalidomide and lenalidomide have both been tested for treatment of mucosa-associated lymphoid tissue (MALT) lymphoma, with lenalidomide, in particular, showing promising activity. However, long-term results are missing. Because of the late-onset remissions registered in individual patients, we have systemically analyzed the patients treated with IMiDs at our institution for long-term results. Methods. Within t...περισσότερα »
Brentuximab Vedotin (Adcetris) for the Treatment of Adult Patients With Relapsed or Refractory CD30+ Hodgkin Lymphoma or Systemic Anaplastic Large Cell Lymphoma
The European Medicines Agency Review of Brentuximab Vedotin (Adcetris) for the Treatment of Adult Patients With Relapsed or Refractory CD30+ Hodgkin Lymphoma or Systemic Anaplastic Large Cell Lymphoma: Summary of the Scientific Assessment of the Committee for Medicinal Products for Human Use: Background. On October 25, 2012, a conditional marketing authorization valid throughout the European Union (EU) was issued for brentuximab vedotin for the treatment of adult patients with relapsed or refractory CD30+ Hodgkin lymphoma (HL) and for the treatment of adult patients with relapsed or... περισσότερα »
Invasive-related biomarkers of non-functioning pituitary adenomas
Integrative proteomics and transcriptomics identify novel invasive-related biomarkers of non-functioning pituitary adenomas: AbstractNon-functioning pituitary adenomas (NFPAs) are usually macroadenomas and display invasion into surrounding tissues. The treatment for invasive NFPAs is still challenging. This study describes the differential patterns of gene expression between invasive and non-invasive NFPAs and identifies novel biomarkers involved in invasion of NFPAs for diagnosis and treatment. Using gene microarray technology, we examined the gene expression profile and found 116...περισσότερα »
Co-occurring adverse events enable early prediction of progression-free survival in metastatic renal cell carcinoma patients treated with sunitinib: a hypothesis-generating study.
[image: http:--http://ift.tt/1SLHBms] Related Articles *Co-occurring adverse events enable early prediction of progression-free survival in metastatic renal cell carcinoma patients treated with sunitinib: a hypothesis-generating study.* Tumori. 2015 Sep-Oct;101(5):555-9 Authors: Kucharz J, Dumnicka P, Kuzniewski M, Kusnierz-Cabala B, Herman RM, Krzemieniecki K Abstract AIMS AND BACKGROUND: Clinical practice shows significant differences in treatment outcomes and toxicity of sunitinib across patients. This retrospective study assessed early predictive markers for progression-free ... περισσότερα »
Editorial: Long Term Follow-Up of Visual Acuity After anti-VEGF Therapy in Neovascular Age-Related Macular Degeneration.
[image: http:--http://ift.tt/1SvbKVd] Related Articles *Editorial: Long Term Follow-Up of Visual Acuity After anti-VEGF Therapy in Neovascular Age-Related Macular Degeneration.* Klin Monbl Augenheilkd. 2015 Apr;232(4):366 Authors: Guex-Crosier Y PMID: 25902076 [PubMed - indexed for MEDLINE] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1P6TtJV via IFTTT
Anti-apoptotic, anti-oxidant, and anti-inflammatory effects of thalidomide on cerebral ischemia/reperfusion injury in rats.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Anti-apoptotic, anti-oxidant, and anti-inflammatory effects of thalidomide on cerebral ischemia/reperfusion injury in rats.* J Neurol Sci. 2015 Apr 15;351(1-2):78-87 Authors: Palencia G, Medrano JÁ, Ortiz-Plata A, Farfán DJ, Sotelo J, Sánchez A, Trejo-Solís C Abstract Thalidomide has shown protective effects in different models of ischemia/reperfusion damage. To elucidate the mechanisms of such protection, this study assessed the effects of thalidomide on the oxidative stress and inflammatory response induced by ... περισσότερα »
Role of endogenous PDGF-BB in cultured cardiomyocytes exposed to hypoxia.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Role of endogenous PDGF-BB in cultured cardiomyocytes exposed to hypoxia.* Neuropeptides. 2015 Apr;50:43-9 Authors: Rong R, Wang YC, Hu LQ, He QQ, Zhou XF, Wang TH, Bu PL Abstract Platelet-derived growth factor-BB (PDGF-BB) plays a critical role in cell proliferation, angiogenesis and fibrosis. However, its exact role in cardiomyocytes exposed to hypoxia is not well known. This study was therefore designed to detect whether PDGF-BB expression was changed in a hypoxic condition, then the possible role of endogenous... περισσότερα »
Cerebral peduncle tumor ablated by novel 3-mm laser tip.
[image: http:--misc.karger.com-LinkOutIcons-sk_n] Related Articles *Cerebral peduncle tumor ablated by novel 3-mm laser tip.* Stereotact Funct Neurosurg. 2015;93(1):38-41 Authors: Xu DS, Rosenfeld A, Ponce FA, Nakaji P, Bhardwaj RD Abstract BACKGROUND/OBJECTIVE: Decisions to use open surgery or radiotherapy in pediatric patients with familial neoplastic syndromes must consider not only the symptomatic benefits of treatment, but also future limitations these treatments may impose. Specifically, open surgical resection of noncurable tumors may preclude or encumber future lesion rese... περισσότερα »
Determination of sunitinib and its active metabolite, N-desethyl sunitinib in mouse plasma and tissues by UPLC-MS/MS: assay development and application to pharmacokinetic and tissue distribution studies.
[image: http:--media.wiley.com-assets-7315-19-Wi] [image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Determination of sunitinib and its active metabolite, N-desethyl sunitinib in mouse plasma and tissues by UPLC-MS/MS: assay development and application to pharmacokinetic and tissue distribution studies.* Biomed Chromatogr. 2015 May;29(5):679-88 Authors: Chen X, Wang Z, Liu M, Liao M, Wang X, Du H, Chen J, Yao M, Li Q Abstract A simple, sensitive and specific method using ultraperformance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) was developed to ... περισσότερα »
Case of erythema elevatum diutinum associated with IgA paraproteinemia successfully controlled with thalidomide and plasma exchange.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Case of erythema elevatum diutinum associated with IgA paraproteinemia successfully controlled with thalidomide and plasma exchange.* Ther Apher Dial. 2015 Apr;19(2):195-6 Authors: Manni E, Cervadoro E, Papineschi F PMID: 25257541 [PubMed - indexed for MEDLINE] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1P6Tspv via IFTTT
Thiazide-associated Hypercalcemia: Incidence and Association with Primary Hyperparathyroidism over Two Decades.
*Thiazide-associated Hypercalcemia: Incidence and Association with Primary Hyperparathyroidism over Two Decades.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153964 Authors: Griebeler ML, Kearns AE, Ryu E, Thapa P, Hathcock MA, Melton LJ, Wermers RA Abstract CONTEXT: Thiazide diuretics, the antihypertensive agent prescribed most frequently worldwide, are commonly associated with hypercalcemia. However, the epidemiology and clinical features are poorly understood. OBJECTIVE: To update the incidence of thiazide-associated hypercalcemia and clarify its clinical features. PATIENTS AND ... περισσότερα »
Musculoskeletal and endocrine health in adults with cerebral palsy: new opportunities for intervention.
*Musculoskeletal and endocrine health in adults with cerebral palsy: new opportunities for intervention.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153888 Authors: Trinh A, Wong P, Fahey MC, Brown J, Churchyard A, Strauss BJ, Ebeling PR, Fuller PJ, Milat F Abstract CONTEXT: Cerebral palsy (CP) increases fracture risk through diminished ambulation, nutritional deficiencies and anticonvulsant medication use. Studies examining bone mineral density (BMD) in adults with CP are limited. OBJECTIVE: To examine the relationship between body composition, BMD, and fractures in adults with C...περισσότερα »
Advances in Supportive Care for Late Effects of Head and Neck Cancer.
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Advances in Supportive Care for Late Effects of Head and Neck Cancer.* J Clin Oncol. 2015 Oct 10;33(29):3314-21 Authors: Murphy BA, Deng J Abstract As the population of head and neck cancer survivors increases, it has become increasingly important for health care providers to understand and manage late complications of therapy. Functional deficits can be categorized as general health deficits resulting in frailty or debility, head and neck-specific functional deficits such as swallowing and speech, and musculoske... περισσότερα »
Diffuse idiopathic skeletal hyperostosis as a cause of dysphagia in a young patient with metabolic syndrome.
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Diffuse idiopathic skeletal hyperostosis as a cause of dysphagia in a young patient with metabolic syndrome.* PM R. 2015 Apr;7(4):451-2 Authors: Agirman M, Durmus O, Ormeci T, Teker B, Cakar E PMID: 25460208 [PubMed - indexed for MEDLINE] from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1TS4hjw via IFTTT
[Multidisciplinary daytime hospitalisation for swallowing disorders: Its value and limitations. Our practice in the University Hospital of Tours].
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Related Articles *[Multidisciplinary daytime hospitalisation for swallowing disorders: Its value and limitations. Our practice in the University Hospital of Tours].* Rev Laryngol Otol Rhinol (Bord). 2014;135(2):87-90 Authors: Marmouset F Abstract Swallowing disorders are in many cases serious and complex. Their management needs to be considered from several perspectives. Multidisciplinary daytime hospitalisation (MDH) for swallowing disorders is an appropriate solution for many patients: a single day is sufficient for a complete check-up and the initiation of a therapeutic progra... περισσότερα »
Ttreatment-related changes and progressive disease (PD) : using support vector machine classification based on DCE MRI
Differentiation between treatment-related changes and progressive disease in patients with high grade brain tumors using support vector machine classification based on DCE MRI: AbstractDifferentiation between treatment-related changes and progressive disease (PD) remains a major clinical challenge in the follow-up of patients with high grade brain tumors. The aim of this study was to differentiate between treatment-related changes and PD using dynamic contrast enhanced (DCE) MRI. Twenty patients were scanned using conventional, DCE-MRI and MR spectroscopy (total of 44 MR scans). Th...περισσότερα »
Prevention and treatment of sepsis-induced acute kidney injury: An update
Annals of Intensive Care from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SLDSoX via IFTTT
Risk factors associated with ipsilateral ischemic events following carotid endarterectomy (CEA) for carotid artery stenosis
World Neurosurgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1P6yvea via IFTTT
Pulmonary macrophages activity in CO intoxication
Journal of Forensic and Legal Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SLDS8C via IFTTT
Extent and Impact of Opioid Prescribing for Acute Occupational Low Back Pain in the Emergency Department
The Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1P6ysPw via IFTTT
Health-related quality of life among caregivers of individuals with spinal cord injury
Journal of Neuroscience Nursing from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SLDS8t via IFTTT
Risk of fall-related injury in people with lower limb amputations: A prospective cohort study
Journal of Rehabilitation Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1P6yuH6 via IFTTT
Expecting the unexpected: A mixed methods study of violence to EMS responders in an urban fire department
American Journal of Industrial Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SLDUNH via IFTTT
Effects of continuity of care on emergency department utilization in children with asthma
The American Journal of Managed Care from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SLDRRT via IFTTT
Variables associated with parent satisfaction with their child's pain management
Emergency Medicine Australasia from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1P6ysiB via IFTTT
The predictive value of soluble endothelial selectin plasma levels in children with acute lung injury
Journal of Critical Care from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SLDRBw via IFTTT
Street crossing behavior in younger and older pedestrians: an eye- and head-tracking study
BMC Geriatrics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SLDUgJ via IFTTT
Utility of computed tomography in elbow trauma patients with normal x-ray study and positive elbow extension test
The Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1P6yruW via IFTTT
Bedside lung ultrasound for monitoring the effectiveness of prehospital treatment with continuous positive airway pressure in acute decompensated heart failure
European Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SLDU0i via IFTTT
High prevalence of pharmacologically induced platelet dysfunction in the acute setting of brain injury
Acta Neurochirurgica from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1P6yruR via IFTTT
Correction of medial blowout fractures according to the fracture types
Annals of Plastic Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SLDU0c via IFTTT
Expression of the CSC markers CD44, MET and SLC3A2, and hypoxia gene signatures
Low CSC marker expression and low hypoxia identify good prognosis subgroups in HPV(-)HNSCC after postoperative radiochemotherapy: a multicenter study of the DKTK-ROG: Purpose: To investigate the impact of hypoxia-induced gene expression and cancer stem cell (CSC) marker expression on outcome of postoperative cisplatin-based radiochemotherapy (PORT-C) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Experimental Design: Expression of the CSC markers CD44, MET and SLC3A2, and hypoxia gene signatures were analyzed in the resected primary tumors using RT... περισσότερα »
Postoperative cisplatin-based radiochemotherapy (PORT-C) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC)
Low CSC marker expression and low hypoxia identify good prognosis subgroups in HPV(-)HNSCC after postoperative radiochemotherapy: a multicenter study of the DKTK-ROG: Purpose: To investigate the impact of hypoxia-induced gene expression and cancer stem cell (CSC) marker expression on outcome of postoperative cisplatin-based radiochemotherapy (PORT-C) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Experimental Design: Expression of the CSC markers CD44, MET and SLC3A2, and hypoxia gene signatures were analyzed in the resected primary tumors using RT... περισσότερα »
Low CSC marker expression and low hypoxia identify good prognosis subgroups in HPV(-)HNSCC after postoperative radiochemotherapy: a multicenter study of the DKTK-ROG
Low CSC marker expression and low hypoxia identify good prognosis subgroups in HPV(-)HNSCC after postoperative radiochemotherapy: a multicenter study of the DKTK-ROG: Purpose: To investigate the impact of hypoxia-induced gene expression and cancer stem cell (CSC) marker expression on outcome of postoperative cisplatin-based radiochemotherapy (PORT-C) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Experimental Design: Expression of the CSC markers CD44, MET and SLC3A2, and hypoxia gene signatures were analyzed in the resected primary tumors using RT... περισσότερα »
The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH CD44 Tumor Cell Expression in Non Hodgkin Lymphomas
The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH CD44 Tumor Cell Expression in Non Hodgkin Lymphomas: AbstractPrognostic significance of immune microenvironment has been emphasized using the most advanced analysis, with consecutive attempts to reveal prognostic impact of this findings. The aim of this study was to compare and define prognostic significance of clinical parameters, microvessel density (MVD) in tumour tissue and expression of CD44s as adhesive molecule on tumour cells in diffuse large B cell lymphoma-DLBCL, primary central nervous system DLBCL-CN... περισσότερα »
Sentinel lymph node identification using superparamagnetic iron oxide particles versus radioisotope: The French Sentimag feasibility trial
Sentinel lymph node identification using superparamagnetic iron oxide particles versus radioisotope: The French Sentimag feasibility trial: Background and Objectives The French Sentimag feasibility trial evaluated a new method for the localization of breast cancer sentinel lymph node (SLN) using Sienna+®, superparamagnetic iron oxide particles, and Sentimag® detection in comparison to the standard technique (isotopes ± blue dye). Methods We conducted a prospective multicentric paired comparison trial on 115 patients. SLN localization was performed using both the magnetic technique a...περισσότερα »
Prognostic significance of tumor regression grade for patients with esophageal squamous cell carcinoma after neoadjuvant chemotherapy followed by surgery
Prognostic significance of tumor regression grade for patients with esophageal squamous cell carcinoma after neoadjuvant chemotherapy followed by surgery: Background and objectives To clarify prognostic factors for the patients with esophageal squamous cell carcinoma (ESCC) through an assessment of surgically resected specimens modified by neoadjuvant chemotherapy (nCT). Methods We retrospectively reviewed the clinicopathological data of 143 consecutive patients with ESCC who underwent nCT followed by surgery between 2008 and 2012 at our institution and conducted survival analysis. ...περισσότερα »
IL-32α has differential effects on proliferation and apoptosis of human melanoma cell lines
IL-32α has differential effects on proliferation and apoptosis of human melanoma cell lines: Background Interleukin-32 (IL-32) is a recently recognized intracellular, proinflammatory cytokine which may play a role in cancer metastasis and patient survival. The role of IL-32 in cancer, especially its direct effect on cancer cells, is not well understood. Material and Methods Clonogenic assay, PCNA staining, Quick Cell Proliferation assay, TUNEL staining, and caspase-3 activity assay were used to investigate the in vitro role for IL-32α in human melanoma growth. We further investigate... περισσότερα »
Predictive factors of dysphagia after lateral and superior oropharyngeal reconstruction with free flap transfer
Predictive factors of dysphagia after lateral and superior oropharyngeal reconstruction with free flap transfer: Background and Objectives Lateral and superior oropharyngeal reconstruction is technically challenging and can be complicated by postoperative dysphagia. The aim of this retrospective study was to identify the predictive factors of dysphagia after lateral and superior oropharyngeal reconstruction with free flap transfer and to establish better management for cases with these predictive factors. Methods We performed a retrospective chart review of 109 patients who had unde... περισσότερα »
Expression of the potential cancer stem cell markers CD133 and CD44 in medullary thyroid carcinoma: A ten-year follow-up and prognostic analysis
Expression of the potential cancer stem cell markers CD133 and CD44 in medullary thyroid carcinoma: A ten-year follow-up and prognostic analysis: Background and Objectives To investigate the expression profiles of cancer stem cells (CSCs) markers CD133 and CD44 in a cohort of medullary thyroid carcinoma (MTC) patients, and their prognostic values during 10-year follow-up. Methods MTC samples were obtained for H&E and immunohistochemical analysis. Survival analysis was performed using Kaplan–Meier method and log-rank test. Results Both the CD133 and CD44 positives were higher in MTC th... περισσότερα »
Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model
Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model: Background and Objectives Molecularly targeted fluorescent molecules may help detect tumors that are unseen by traditional white-light surgical techniques. We sought to evaluate a fluorescent ratiometric activatable cell penetrating peptide (RACPP) for tumor detection in a transgenic model of PTC. Methods Thirteen BRAFV600E mice with PTC were studied—seven injected intravenously with RACPP, four controls with saline. Total thyr...περισσότερα »
Metastatic Mantle Cell Lymphoma to the Pituitary Gland
Metastatic Mantle Cell Lymphoma to the Pituitary Gland: Case Report and Literature Review: We present an unusual case of a metastatic mantle cell lymphoma (MCL) to the pituitary gland. The patient had a known history of MCL for which she previously received chemotherapy. She presented with new-onset diplopia and confusion, and reported a history of progressive vision blurriness associated with headache, nausea, and vomiting. MRI of the brain showed an enhancing lesion within the sella turcica involving the cavernous sinuses bilaterally, extending into Meckel's cave on the left, and ...περισσότερα »
Sleep and Fatigue
Pilot Study of Massage to Improve Sleep and Fatigue in Hospitalized Adolescents With Cancer: Background Adolescents with cancer experience many troubling symptoms, including sleep disruptions that can affect mood and quality of life. Massage is a safe and popular intervention that has demonstrated efficacy in pediatric and adult patients with cancer. This study aimed to assess the feasibility of conducting a massage intervention to help with sleep in hospitalized adolescent oncology patients. Procedure Adolescents ages 12–21 with cancer who were expected to be hospitalized for at l...περισσότερα »
Cerebrovascular Disease and Late Effects After Radiation Therapy for Craniopharyngioma
A Cross-Sectional Cohort Study of Cerebrovascular Disease and Late Effects After Radiation Therapy for Craniopharyngioma: [image: cover.gif?v=1&s=aca24c650f05e7b82a6847eb] Background The study objective was to describe radiation-induced vascular abnormalities, stroke prevalence, and stroke risk factors in survivors of childhood craniopharyngioma. Procedure Twenty survivors of childhood craniopharyngioma who received radiotherapy (RT) were included in the study. A clinical history, quality of life assessment, cognitive functioning assessment, magnetic resonance angiogram or compu... περισσότερα »
Predictive factors of dysphagia after lateral and superior oropharyngeal reconstruction with free flap transfer
Predictive factors of dysphagia after lateral and superior oropharyngeal reconstruction with free flap transfer: Background and Objectives Lateral and superior oropharyngeal reconstruction is technically challenging and can be complicated by postoperative dysphagia. The aim of this retrospective study was to identify the predictive factors of dysphagia after lateral and superior oropharyngeal reconstruction with free flap transfer and to establish better management for cases with these predictive factors. Methods We performed a retrospective chart review of 109 patients who had unde... περισσότερα »
NF1 : Systemic Chemotherapy and White Matter Integrity in Tracts Associated with Cognition Among Children With Neurofibromatosis Type 1
Systemic Chemotherapy and White Matter Integrity in Tracts Associated with Cognition Among Children With Neurofibromatosis Type 1: Background Children with neurofibromatosis type 1 (NF1) are predisposed to both brain tumors and cognitive deficits. While changes in white matter integrity after multimodal therapy are associated with cognitive dysfunction, the effect of isolated chemotherapy in NF1 is unknown. To determine whether chemotherapy is associated with white matter microstructural changes, we examined diffusion tensor imaging (DTI) in NF1 subjects. Procedure We reviewed DTI m... περισσότερα »
Alveolar Rhabdomyosarcoma With Low-Risk Clinical Features
Histology, Fusion Status, and Outcome in Alveolar Rhabdomyosarcoma With Low-Risk Clinical Features: A Report From the Children's Oncology Group: [image: cover.gif?v=1&s=aca24c650f05e7b82a6847eb] Background Distinguishing alveolar rhabdomyosarcoma (ARMS) from embryonal rhabdomyosarcoma (ERMS) is of prognostic and therapeutic importance. Criteria for classifying these entities evolved significantly from 1995 to 2013. ARMS is associated with inferior outcome; therefore, patients with alveolar histology have generally been excluded from low-risk therapy. However, patients with ARMS ... περισσότερα »
Robust Thyroid Gene Expression and Radioiodine Uptake Induced by Simultaneous Suppression of BRAF V600E and Histone Deacetylase in Thyroid Cancer Cells.
*Robust Thyroid Gene Expression and Radioiodine Uptake Induced by Simultaneous Suppression of BRAF V600E and Histone Deacetylase in Thyroid Cancer Cells.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153433 Authors: Cheng W, Liu R, Zhu G, Wang H, Xing M Abstract Context Use of BRAF V600E inhibitors to restore thyroid iodide-handing gene expression and radioactive iodine (RAI) avidity is an attractive therapeutic strategy for RAI-refractory thyroid cancer, but recent initial clinical responses were modest. Given histone deacetylation at the sodium/iodide symporter (NIS) promoter by ...περισσότερα »
Audiological comparison between two different clips prostheses in stapes surgery.
*Audiological comparison between two different clips prostheses in stapes surgery.* Rev Laryngol Otol Rhinol (Bord). 2015;136(1):33-6 Authors: Potena M, Portmann D, Guindi S Abstract OBJECTIVES: To compare audiometric results and complications of stapes surgery with two different types of piston prosthesis, the Portmann Clip Piston (Medtronic) (PCP) and the Soft Clip Piston (Kurz) (SCP). MATERIAL AND METHODS: Study conducted on 64 patients who underwent primary stapedotomy from 2008 to 2011. We matched for each case of stapedotomy with the PCP (Medtronic Xomed Inc. Portmann Clip ... περισσότερα »
Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps.
*Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps.* Int Forum Allergy Rhinol. 2016 Jan 11; Authors: Carroll WW, Schlosser RJ, O'Connell BP, Soler ZM, Mulligan JK Abstract BACKGROUND: Vitamin D3 (VD3) is a steroid hormone with known antiproliferative properties. Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have been shown to be VD3-deficient. Moreover, VD3 deficiency is associated with worse disease in patients with CRSwNP. One cell type thought to play a role in chronic rhinos... περισσότερα »
Caries and Candida colonisation in adult patients in Basque Country (Spain)
[image: cover.gif?v=1&s=09d3f8c75474f06ee5ac3319] Summary *Candida albicans* is one of the most frequent pathogens of the oral cavity, as a major cause of opportunistic disease. Moreover, *Candida* could be a cofactor of common oral diseases, such as dental caries. The aim of this study was to analyse the oral yeast colonisation in adults with dental caries and to evaluate its relationship with this clinical entity. We studied 190 patients distributed into controls (58 patients) and patients with caries (132 patients). Oral samples were collected by oral rinse and cultured in a c... περισσότερα »
Genotyping of clinical and environmental Aspergillus flavus isolates from Iran using microsatellites
[image: cover.gif?v=1&s=09d3f8c75474f06ee5ac3319] Summary *Aspergillus flavus* is the second most important *Aspergillus* species causing human infections in tropical countries. Despite an increasing number of infections of *A. flavus* in Iran, the molecular epidemiology of clinical and environmental strains has not been well studied. We used a panel of nine microsatellite markers to analyse the genetic relatedness of *A. flavus*. Microsatellite typing of 143 (*n* = 119 clinical and *n* = 24 environmental) isolates demonstrated 118 different genotypes. A possible outbreak at a pu...περισσότερα »
Effects of Aloe barbadensis Mill. extract (AVH200®) on human blood T cell activity in vitro
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 17 February 2016 Source:Journal of Ethnopharmacology, Volume 179 Author(s): Bani Ahluwalia, Maria K. Magnusson, Stefan Isaksson, Fredrik Larsson, Lena Öhman Ethnopharmacological relevanceAloe barbadensis Mill. (Aloe vera) is a widely used medicinal plant well reputed for its diverse therapeutic applications. It has been used for thousands of years in folk medicine to treat various […]
Observation of an improved healing process in superficial skin wounds after irradiation with a blue-LED haemostatic device
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The healing process of superficial skin wounds treated with a blue-LED haemostatic device is studied. Four mechanical abrasions are produced on the back of 10 Sprague Dawley rats: two are treated with the blue-LED device, while the other two are left to naturally recover. Visual observations, non-linear microscopic imaging, as well as histology and immunofluorescence […]
Will computers ever truly understand what we’re saying?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Brain scans during communication game pinpoint areas where minds meet.From Apple’s Siri to Honda’s robot Asimo, machines seem to be getting better and better at communicating with humans. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Pp9POA via IFTTT
Cancers, Vol. 8, Pages 14: The Effect of Stromal Integrin β3-Deficiency on Two Different Tumors in Mice
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
There is an increasing focus on the tumor microenvironment in carcinogenesis. Integrins are important receptors and adhesion molecules in this environment and have been shown to be involved in cell adhesion, proliferation, differentiation and migration. The present study aimed to evaluate the effect of stromal integrin β3-deficiency on tumor growth, angiogenesis, interstitial fluid pressure (PIF), […]
Cancers, Vol. 8, Pages 13: Cell Proliferation in Neuroblastoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Neuroblastoma, the most common extracranial solid tumor of childhood, continues to carry a dismal prognosis for children diagnosed with advanced stage or relapsed disease. This review focuses upon factors responsible for cell proliferation in neuroblastoma including transcription factors, kinases, and regulators of the cell cycle. Novel therapeutic strategies directed toward these targets in neuroblastoma are […]
Cancers, Vol. 8, Pages 12: Benefits of Minimal Access Surgery in Elderly Patients with Pelvic Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
An increasing proportion of patients requiring treatment for malignancy are elderly, which has created new challenges for oncologic surgeons. Aging is associated with an increasing prevalence of frailty and comorbidities that may affect the outcome of surgical procedures. By decreasing complications and shortening length of hospital stay without affecting oncologic safety, surgery performed using the […]
Adult acute lymphoblastic leukemia with a rare b3a3 type BCR/ABL1 fusion transcript
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 11 January 2016 Source:Cancer Genetics Author(s): Daisuke Kurita, Yoshihiro Hatta, Atsuko Hojo, Yoshimasa Kura, Umihiko Sawada, Yoshinobu Kanda, Masami Takei The Philadelphia chromosome (Ph) is the most frequent chromosomal abnormality detected in adult acute lymphoblastic leukemia (ALL). This chromosome forms the BCR/ABL1 fusion gene, thus ABL1 exon a2 is generally used […]
Congenital Cytomegalovirus.
*Congenital Cytomegalovirus.* Adv Neonatal Care. 2016 Jan 8; Authors: Mestas E Abstract BACKGROUND: Congenital cytomegalovirus (CMV) is the leading viral intrauterine infection in the United States. It causes more developmental delays and long-term sequelae than Down syndrome (trisomy 21), neural tube defects, or fetal alcohol syndrome combined. Yet, this virus, a member of the herpes virus family, is not well known to the public and its prevention is typically not discussed in obstetric offices. Although many infants with congenital CMV are asymptomatic at birth, a significant ... περισσότερα »
Audiological comparison between two different clips prostheses in stapes surgery.
*Audiological comparison between two different clips prostheses in stapes surgery.* Rev Laryngol Otol Rhinol (Bord). 2015;136(1):33-6 Authors: Potena M, Portmann D, Guindi S Abstract OBJECTIVES: To compare audiometric results and complications of stapes surgery with two different types of piston prosthesis, the Portmann Clip Piston (Medtronic) (PCP) and the Soft Clip Piston (Kurz) (SCP). MATERIAL AND METHODS: Study conducted on 64 patients who underwent primary stapedotomy from 2008 to 2011. We matched for each case of stapedotomy with the PCP (Medtronic Xomed Inc. Portmann Clip ... περισσότερα »
Caries and Candida colonisation in adult patients in Basque Country (Spain)
[image: cover.gif?v=1&s=09d3f8c75474f06ee5ac3319] Summary *Candida albicans* is one of the most frequent pathogens of the oral cavity, as a major cause of opportunistic disease. Moreover, *Candida* could be a cofactor of common oral diseases, such as dental caries. The aim of this study was to analyse the oral yeast colonisation in adults with dental caries and to evaluate its relationship with this clinical entity. We studied 190 patients distributed into controls (58 patients) and patients with caries (132 patients). Oral samples were collected by oral rinse and cultured in a c... περισσότερα »
Quantifying lingual coarticulation using ultrasound imaging data collected with and without head stabilisation.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Quantifying lingual coarticulation using ultrasound imaging data collected with and without head stabilisation.* Clin Linguist Phon. 2015 Apr;29(4):249-65 Authors: Zharkova N, Gibbon FE, Hardcastle WJ Abstract Previous studies reporting the use of ultrasound tongue imaging with clinical populations have generally provided qualitative information on tongue movement. Meaningful quantitative measures for use in the clinic typically require the speaker's head to be stabilised in relation to a transducer, which may be uncomfortab... περισσότερα »
Norwegian words: A lexical database for clinicians and researchers.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Norwegian words: A lexical database for clinicians and researchers.* Clin Linguist Phon. 2015 Apr;29(4):276-90 Authors: Lind M, Simonsen HG, Hansen P, Holm E, Mevik BH Abstract All words have properties linked to form, meaning and usage patterns which influence how easily they are accessed from the mental lexicon in language production, perception and comprehension. Examples of such properties are imageability, phonological and morphological complexity, word class, argument structure, frequency of use and age of acquisition. ... περισσότερα »
Systemic Chemotherapy and White Matter Integrity in Tracts Associated with Cognition Among Children With Neurofibromatosis Type 1
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background Children with neurofibromatosis type 1 (NF1) are predisposed to both brain tumors and cognitive deficits. While changes in white matter integrity after multimodal therapy are associated with cognitive dysfunction, the effect of isolated chemotherapy in NF1 is unknown. To determine whether chemotherapy is associated with white matter microstructural changes, we examined diffusion tensor imaging […]
A Cross-Sectional Cohort Study of Cerebrovascular Disease and Late Effects After Radiation Therapy for Craniopharyngioma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background The study objective was to describe radiation-induced vascular abnormalities, stroke prevalence, and stroke risk factors in survivors of childhood craniopharyngioma. Procedure Twenty survivors of childhood craniopharyngioma who received radiotherapy (RT) were included in the study. A clinical history, quality of life assessment, cognitive functioning assessment, magnetic resonance angiogram or computed tomography angiogram, fasting lipid […]
Pilot Study of Massage to Improve Sleep and Fatigue in Hospitalized Adolescents With Cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background Adolescents with cancer experience many troubling symptoms, including sleep disruptions that can affect mood and quality of life. Massage is a safe and popular intervention that has demonstrated efficacy in pediatric and adult patients with cancer. This study aimed to assess the feasibility of conducting a massage intervention to help with sleep in hospitalized […]
Improved Splenic Function After Hematopoietic Stem Cell Transplant for Sickle Cell Disease
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background Splenic dysfunction is a significant complication of sickle cell disease (SCD). Hematopoietic stem cell transplant (HSCT) is a proven cure for SCD; however, its long-term effect on splenic function is not well characterized. Procedure We conducted a retrospective cohort study of pediatric patients who had HSCT for SCD at two transplant centers. 99mTc liver–spleen […]
Immunobullous disease and ulcerative colitis: the need of an accurate diagnosis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract In their paper entitled ‘‘Immunobullous disease and ulcerative colitis: a case series of six patients”, Sotiriou and cols1 describe six patients with different immunobullous diseases and concomitant ulcerative colitis. In case 1, linear IgA bullous dermatosis (LABD) diagnosis was made exclusively by histopathologic and direct immunofluorescence findings. This article is protected by copyright. All […]
Reply to: Validation of database search strategies for the epidemiological study of pemphigus and pemphigoid: reply from authors
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract We read the response to our manuscript 1 by Professor Langan and group 2. Indeed, not all studies have been limited to single centers with smaller cohorts. We were aware of their excellent studies of pemphigus and pemphigoid and certainly did not mean to ignore them. The studies of Langan et al. were performed […]
Cancers, Vol. 8, Pages 14: The Effect of Stromal Integrin β3-Deficiency on Two Different Tumors in Mice
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
There is an increasing focus on the tumor microenvironment in carcinogenesis. Integrins are important receptors and adhesion molecules in this environment and have been shown to be involved in cell adhesion, proliferation, differentiation and migration. The present study aimed to evaluate the effect of stromal integrin β3-deficiency on tumor growth, angiogenesis, interstitial fluid pressure (PIF), […]
Cancers, Vol. 8, Pages 13: Cell Proliferation in Neuroblastoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Neuroblastoma, the most common extracranial solid tumor of childhood, continues to carry a dismal prognosis for children diagnosed with advanced stage or relapsed disease. This review focuses upon factors responsible for cell proliferation in neuroblastoma including transcription factors, kinases, and regulators of the cell cycle. Novel therapeutic strategies directed toward these targets in neuroblastoma are […]
Cancers, Vol. 8, Pages 12: Benefits of Minimal Access Surgery in Elderly Patients with Pelvic Cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
An increasing proportion of patients requiring treatment for malignancy are elderly, which has created new challenges for oncologic surgeons. Aging is associated with an increasing prevalence of frailty and comorbidities that may affect the outcome of surgical procedures. By decreasing complications and shortening length of hospital stay without affecting oncologic safety, surgery performed using the […]
Shotgun pellet embolization to the posterior cerebral artery
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Introduction Projectile embolization to the cerebral vasculature and is almost exclusively seen in the anterior circulation due to the greater diameter and flow of the internal carotid arteries. In children, this phenomenon is ever rarer. Methods We present a case of a 9-year-old boy who suffered from a shotgun blast to the thorax and […]
LONG-TERM SAFETY OF LETROZONE AND GONADOTROPIN STIMULATION FOR FERTILITY PRESERVATION IN WOMEN WITH BREAST CANCER.
*LONG-TERM SAFETY OF LETROZONE AND GONADOTROPIN STIMULATION FOR FERTILITY PRESERVATION IN WOMEN WITH BREAST CANCER.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153878 Authors: Kim J, Turan V, Oktay K Abstract CONTEXT AND OBJECTIVE: There has been increased attention to the issue of fertility preservation (FP). We aimed to investigate the long-term safety of FP via controlled ovarian stimulation with letrozole supplementation (COSTLES) prior to breast cancer treatment. DESIGN, SETTING AND PARTICIPANTS: This is a prospective non-randomized controlled study conducted between the year... περισσότερα »
Effect of Hesperidin with and without a Calcium (Calcilock®) Supplement on Bone Health in Postmenopausal Women.
*Effect of Hesperidin with and without a Calcium (Calcilock®) Supplement on Bone Health in Postmenopausal Women.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153767 Authors: Martin BR, McCabe GP, McCabe L, Jackson GS, Horcajada MN, Offord-Cavin E, Peacock M, Weaver CM Abstract CONTEXT: Citrus fruits contain unique flavanones. One of the most abundant of the flavanones, hesperidin, has been shown to prevent bone loss in ovariectomized rats. OBJECTIVE: The objective of the study was to measure the effect of hesperidin with or without calcium supplementation on bone calcium retention... περισσότερα »
Impact of delay in diagnosis in outcomes in MEN1: results from the Dutch MEN1 study group.
*Impact of delay in diagnosis in outcomes in MEN1: results from the Dutch MEN1 study group.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153766 Authors: van Leeuwaarde RS, van Nesselrooij BP, Hermus AR, Dekkers OM, de Herder WW, van der Horst-Schrivers AN, Drent ML, Bisschop PH, Havekes B, Vriens MR, de Laat JM, Pieterman CR, Valk GD Abstract OBJECTIVE: Identifying a germline mutation in the MEN1 gene in an index case has consequences for a whole family. Eligible family members should be offered genetic counseling and MEN1 mutation testing. Subsequently clinical screening of mutat... περισσότερα »
Single-Dose Study of a Corticotropin-Releasing Factor Receptor-1 Antagonist in Women with 21-Hydroxylase Deficiency.
*Single-Dose Study of a Corticotropin-Releasing Factor Receptor-1 Antagonist in Women with 21-Hydroxylase Deficiency.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153574 Authors: Turcu AF, Spencer-Segal JL, Farber RH, Luo R, Grigoriadis DE, Ramm CA, Madrigal D, Muth T, O'Brien CF, Auchus RJ Abstract CONTEXT: Treatment of 21-hydroxylase deficiency (21OHD) is difficult to optimize. Normalization of excessive adrenocorticotropin (ACTH) and adrenal steroid production commonly requires supraphysiologic doses of glucocorticoids. OBJECTIVES: We evaluated the safety and tolerability of the... περισσότερα »
Robust Thyroid Gene Expression and Radioiodine Uptake Induced by Simultaneous Suppression of BRAF V600E and Histone Deacetylase in Thyroid Cancer Cells.
*Robust Thyroid Gene Expression and Radioiodine Uptake Induced by Simultaneous Suppression of BRAF V600E and Histone Deacetylase in Thyroid Cancer Cells.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153433 Authors: Cheng W, Liu R, Zhu G, Wang H, Xing M Abstract Context Use of BRAF V600E inhibitors to restore thyroid iodide-handing gene expression and radioactive iodine (RAI) avidity is an attractive therapeutic strategy for RAI-refractory thyroid cancer, but recent initial clinical responses were modest. Given histone deacetylation at the sodium/iodide symporter (NIS) promoter by ...περισσότερα »
Androgen-induced relaxation of uterine myocytes is mediated by blockade of both Ca(2+) flux and MLC phosphorylation.
*Androgen-induced relaxation of uterine myocytes is mediated by blockade of both Ca(2+) flux and MLC phosphorylation.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20152851 Authors: Makieva S, Hutchinson LJ, Rajagopal SP, Rinaldi SF, Brown P, Saunders PT, Norman JE Abstract CONTEXT: Uterine quiescence must be maintained until pregnancy reaches term. Premature activation of myometrial contractility leads to preterm labour and delivery. OBJECTIVE: To scrutinise the potential of androgens to relax the myometrium and the mechanism of their action. SAMPLES: A pregnancy-derived myometrial s...περισσότερα »
Thiazide-associated Hypercalcemia: Incidence and Association with Primary Hyperparathyroidism over Two Decades.
*Thiazide-associated Hypercalcemia: Incidence and Association with Primary Hyperparathyroidism over Two Decades.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153964 Authors: Griebeler ML, Kearns AE, Ryu E, Thapa P, Hathcock MA, Melton LJ, Wermers RA Abstract CONTEXT: Thiazide diuretics, the antihypertensive agent prescribed most frequently worldwide, are commonly associated with hypercalcemia. However, the epidemiology and clinical features are poorly understood. OBJECTIVE: To update the incidence of thiazide-associated hypercalcemia and clarify its clinical features. PATIENTS AND ... περισσότερα »
Musculoskeletal and endocrine health in adults with cerebral palsy: new opportunities for intervention.
*Musculoskeletal and endocrine health in adults with cerebral palsy: new opportunities for intervention.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153888 Authors: Trinh A, Wong P, Fahey MC, Brown J, Churchyard A, Strauss BJ, Ebeling PR, Fuller PJ, Milat F Abstract CONTEXT: Cerebral palsy (CP) increases fracture risk through diminished ambulation, nutritional deficiencies and anticonvulsant medication use. Studies examining bone mineral density (BMD) in adults with CP are limited. OBJECTIVE: To examine the relationship between body composition, BMD, and fractures in adults with C...περισσότερα »
LONG-TERM SAFETY OF LETROZONE AND GONADOTROPIN STIMULATION FOR FERTILITY PRESERVATION IN WOMEN WITH BREAST CANCER.
*LONG-TERM SAFETY OF LETROZONE AND GONADOTROPIN STIMULATION FOR FERTILITY PRESERVATION IN WOMEN WITH BREAST CANCER.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153878 Authors: Kim J, Turan V, Oktay K Abstract CONTEXT AND OBJECTIVE: There has been increased attention to the issue of fertility preservation (FP). We aimed to investigate the long-term safety of FP via controlled ovarian stimulation with letrozole supplementation (COSTLES) prior to breast cancer treatment. DESIGN, SETTING AND PARTICIPANTS: This is a prospective non-randomized controlled study conducted between the year... περισσότερα »
Effect of Hesperidin with and without a Calcium (Calcilock®) Supplement on Bone Health in Postmenopausal Women.
*Effect of Hesperidin with and without a Calcium (Calcilock®) Supplement on Bone Health in Postmenopausal Women.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153767 Authors: Martin BR, McCabe GP, McCabe L, Jackson GS, Horcajada MN, Offord-Cavin E, Peacock M, Weaver CM Abstract CONTEXT: Citrus fruits contain unique flavanones. One of the most abundant of the flavanones, hesperidin, has been shown to prevent bone loss in ovariectomized rats. OBJECTIVE: The objective of the study was to measure the effect of hesperidin with or without calcium supplementation on bone calcium retention... περισσότερα »
Short-term prognostic factors in myelomeningocele patients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Purpose Patients with myelomeningocele have a high mortality and neurological disabilities that are correlated with the anatomical characteristics of the defect and with the development of acquired complications. The challenge in the postnatal management of myelomeningocele (MMC) is the early recognition of cases at risk for complications in order to establish individualized treatment strategies. […]
Surgical treatment of Langerhans cell histiocytosis of cervical spine: case report and review of literature
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Introduction Langerhans cell histiocytosis (LCH) is a rare condition, and even rare is cervical spine involvement. Case report A 9-year-old girl had neck pain, neck tilt and left upper limb weakness, occasional fever and positive family history of tuberculosis. Imaging showed C5 vertebral body collapse with epidural and prevertebral soft tissue collection causing cord […]
Reply to: Validation of database search strategies for the epidemiological study of pemphigus and pemphigoid: reply from authors
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract We read the response to our manuscript 1 by Professor Langan and group 2. Indeed, not all studies have been limited to single centers with smaller cohorts. We were aware of their excellent studies of pemphigus and pemphigoid and certainly did not mean to ignore them. The studies of Langan et al. were performed […]
Immunobullous disease and ulcerative colitis: the need of an accurate diagnosis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract In their paper entitled ‘‘Immunobullous disease and ulcerative colitis: a case series of six patients”, Sotiriou and cols1 describe six patients with different immunobullous diseases and concomitant ulcerative colitis. In case 1, linear IgA bullous dermatosis (LABD) diagnosis was made exclusively by histopathologic and direct immunofluorescence findings. This article is protected by copyright. All […]
Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder. Molecules. 2016;21(1) Authors: Wang F, Li Y, Zhang YJ, Zhou Y, Li S, Li HB Abstract Alcoholic beverages such as beer, wine and spirits are widely consumed around the world. However, alcohol and its metabolite acetaldehyde are toxic and harmful to human […]
Evaluation of transforming growth factor-β2 for radiation-induced diarrhea after pelvic radiotherapy.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Related Articles Evaluation of transforming growth factor-β2 for radiation-induced diarrhea after pelvic radiotherapy. Tumori. 2015 Sep-Oct;101(5):474-7 Authors: Demiral S, Beyzadeoglu M, Sager O, Dincoglan F, Uysal B, Gamsiz H, Akin M, Turker T Abstract AIMS AND BACKGROUND: Radiotherapy (RT) plays a central role in the management of cancers located in the abdomen and pelvis. However, […]
Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE study.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Related Articles Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE study. Cancer Causes Control. 2014 Oct;25(10):1283-93 Authors: Ajrouche R, Rudant J, Orsi L, Petit A, Baruchel A, Nelken B, Pasquet M, Michel G, Bergeron C, Ducassou S, Gandemer V, Lutz P, Saumet L, Rialland X, […]
Reply to: Validation of database search strategies for the epidemiological study of pemphigus and pemphigoid: reply from authors
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract We read the response to our manuscript 1 by Professor Langan and group 2. Indeed, not all studies have been limited to single centers with smaller cohorts. We were aware of their excellent studies of pemphigus and pemphigoid and certainly did not mean to ignore them. The studies of Langan et al. were performed […]
Congenital Cytomegalovirus.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Congenital Cytomegalovirus. Adv Neonatal Care. 2016 Jan 8; Authors: Mestas E Abstract BACKGROUND: Congenital cytomegalovirus (CMV) is the leading viral intrauterine infection in the United States. It causes more developmental delays and long-term sequelae than Down syndrome (trisomy 21), neural tube defects, or fetal alcohol syndrome combined. Yet, this virus, a member of the herpes […]
Audiological comparison between two different clips prostheses in stapes surgery.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Audiological comparison between two different clips prostheses in stapes surgery. Rev Laryngol Otol Rhinol (Bord). 2015;136(1):33-6 Authors: Potena M, Portmann D, Guindi S Abstract OBJECTIVES: To compare audiometric results and complications of stapes surgery with two different types of piston prosthesis, the Portmann Clip Piston (Medtronic) (PCP) and the Soft Clip Piston (Kurz) (SCP). MATERIAL […]
Ilya Tsimafeyeu receives prestigious ASCO Merit Award
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Kidney Cancer Association Professional Group member Ilya Tsimafeyeu received the prestigious ASCO Merit Award for his institution’s RCC translational study at the ASCO Gunitourinary Cancer Symposium in San Francisco. His abstract was recognized as a Top Poster in the track.01/11/2016 (Source: Kidney Cancer Association) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ULGUbh via IFTTT
Online support group for people living with kidney cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Registration is now open for CancerCare’s new 15-week online support group for people diagnosed with kidney cancer. This online group provides a safe, confidential space where participants can discuss the unique challenges of living with this illness while receiving support, information and guidance. This group takes place in a password-protected forum that is moderated by […]
Kidney Cancer Highlights From GU ASCO
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Dr. Toni Choueiri, of Dana Farber, presents highlights from ASCO GU 2016 Genitourinary Symposium held in San Francisco01/10/2016 (Source: Kidney Cancer Association) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ULGT7l via IFTTT
Discontinuing VEGF-targeted therapy for progression or toxicity affects outcomes of second-line therapies in mRCC
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Dr de Velasco talks to ecancertv at ASCO GU 2016 about analysing when VEGF-targeted therapy for metastatic renal cell carcinoma (mRCC) is discontinued.01/09/2016 (Source: Kidney Cancer Association) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OMYnQG via IFTTT
Does the difference between PART and Alzheimer's disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau?
[image: http:--production.springer.de-OnlineReso] Related Articles *Does the difference between PART and Alzheimer's disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau?* Acta Neuropathol. 2015 May;129(5):763-6 Authors: Weller RO, Hawkes CA, Carare RO, Hardy J PMID: 25814152 [PubMed - indexed for MEDLINE] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1OfBN1j via IFTTT
Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers.
[image: http:--production.springer.de-OnlineReso] Related Articles *Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers.* Acta Neuropathol. 2015 May;129(5):669-78 Authors: Korshunov A, Ryzhova M, Hovestadt V, Bender S, Sturm D, Capper D, Meyer J, Schrimpf D, Kool M, Northcott PA, Zheludkova O, Milde T, Witt O, Kulozik AE, Reifenberger G, Jabado N, Perry A, Lichter P, von Deimling A, Pfister SM, Jones DT Abstract Pediatric glioblastoma (pedGBM) is amongst the most common malignant brain tumors... περισσότερα »
Autopsy-confirmed hippocampal-sparing Alzheimer's disease with delusional jealousy as initial manifestation.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Autopsy-confirmed hippocampal-sparing Alzheimer's disease with delusional jealousy as initial manifestation.* Psychogeriatrics. 2015 Sep;15(3):198-203 Authors: Fujishiro H, Iritani S, Hattori M, Sekiguchi H, Matsunaga S, Habuchi C, Torii Y, Umeda K, Ozaki N, Yoshida M, Fujita K Abstract Alzheimer's disease (AD) is clinically characterized by gradual onset over years with worsening of cognition. The initial and most prominent cognitive deficit is commonly memory dysfunction. However, a subset of AD cases has less ...περισσότερα »
Menthol tobacco use is correlated with mental health symptoms in a national sample of young adults: implications for future health risks and policy recommendations.
*Menthol tobacco use is correlated with mental health symptoms in a national sample of young adults: implications for future health risks and policy recommendations.* Tob Induc Dis. 2016;14:1 Authors: Cohn AM, Johnson AL, Hair E, Rath JM, Villanti AC Abstract BACKGROUND: Depression and anxiety are correlated with greater nicotine dependence, smoking persistence, and relapse back to smoking after a quit attempt. Menthol cigarette smoking, which is prevalent in young adults, is associated with nicotine dependence, progression to regular smoking, and worse cessation outcomes than n...περισσότερα »
Emerging clinical applications of PET based molecular imaging in oncology: the promising future potential for evolving personalized cancer care.
*Emerging clinical applications of PET based molecular imaging in oncology: the promising future potential for evolving personalized cancer care.* Indian J Radiol Imaging. 2015 Oct-Dec;25(4):332-341 Authors: Dhingra VK, Mahajan A, Basu S Abstract This review focuses on the potential of advanced applications of functional molecular imaging in assessing tumor biology and cellular characteristics with emphasis on positron emission tomography (PET) applications with both 18-fluorodeoxyglucose (FDG) and non-FDG tracers. The inherent heterogeneity of cancer cells with their varied cell...περισσότερα »
Vaccinology: the art of putting together the right ingredients.
*Vaccinology: the art of putting together the right ingredients.* Hum Vaccin Immunother. 2016 Jan 11;:0 Authors: Grandi A, Tomasi M, Grandi G Abstract Historically vaccines were produced using whole attenuated or killed pathogens and still a large proportion of current vaccines utilized such procedure. However, for safety and quality reasons the development of novel vaccines is preferentially based on the selection and use of specific pathogen components which alone are capable of eliciting protective immune responses against the pathogens they derived from. The big challenge for... περισσότερα »
Evaluation of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a community setting: A cost-utility analysis of a hospital's initial experience and reflections on the health care system.
*Evaluation of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a community setting: A cost-utility analysis of a hospital's initial experience and reflections on the health care system.* J Surg Oncol. 2016 Jan 11; Authors: Naffouje SA, O'Donoghue C, Salti GI Abstract BACKGROUND: The combination of Cytoreductive Surgery (CRS) plus Hyperthermic Intraperitoneal Chemotherapy (HIPEC) has been gaining a considerable interest by surgeons throughout the United States due to the significant survival improvement it provides for peritoneal surface malignancies and th...περισσότερα »
Congenital Cytomegalovirus.
*Congenital Cytomegalovirus.* Adv Neonatal Care. 2016 Jan 8; Authors: Mestas E Abstract BACKGROUND: Congenital cytomegalovirus (CMV) is the leading viral intrauterine infection in the United States. It causes more developmental delays and long-term sequelae than Down syndrome (trisomy 21), neural tube defects, or fetal alcohol syndrome combined. Yet, this virus, a member of the herpes virus family, is not well known to the public and its prevention is typically not discussed in obstetric offices. Although many infants with congenital CMV are asymptomatic at birth, a significant p... περισσότερα »
Audiological comparison between two different clips prostheses in stapes surgery.
*Audiological comparison between two different clips prostheses in stapes surgery.* Rev Laryngol Otol Rhinol (Bord). 2015;136(1):33-6 Authors: Potena M, Portmann D, Guindi S Abstract OBJECTIVES: To compare audiometric results and complications of stapes surgery with two different types of piston prosthesis, the Portmann Clip Piston (Medtronic) (PCP) and the Soft Clip Piston (Kurz) (SCP). MATERIAL AND METHODS: Study conducted on 64 patients who underwent primary stapedotomy from 2008 to 2011. We matched for each case of stapedotomy with the PCP (Medtronic Xomed Inc. Portmann Clip P... περισσότερα »
Decision-making and outcomes of hearing help-seekers: A self-determination theory perspective.
*Decision-making and outcomes of hearing help-seekers: A self-determination theory perspective.* Int J Audiol. 2016 Jan 11;:1-10 Authors: Ridgway J, Hickson L, Lind C Abstract OBJECTIVE: To explore the explanatory power of a self-determination theory (SDT) model of health behaviour change for hearing aid adoption decisions and fitting outcomes. DESIGN: A quantitative approach was taken for this longitudinal cohort study. Participants completed questionnaires adapted from SDT that measured autonomous motivation, autonomy support, and perceived competence for hearing aids. Hearing ... περισσότερα »
Initial classification of pediatric hearing impairment using behavioral measures of early prelingual auditory development.
*Initial classification of pediatric hearing impairment using behavioral measures of early prelingual auditory development.* Int J Audiol. 2016 Jan 11;:1-8 Authors: Liang S, Soli SD, Zheng Y, Li G, Meng Z Abstract OBJECTIVE: Determine the sensitivity, specificity, and accuracy of pediatric hearing loss classification using behavioral evidence of early prelingual auditory development (EPLAD). Validate behavioral measures of EPLAD. DESIGN: EPLAD was assessed in a prospective sample of hearing-impaired children using the infant-toddler meaningful auditory integration scale (ITMAIS/M... περισσότερα »
Decision-making and outcomes of hearing help-seekers: A self-determination theory perspective.
*Decision-making and outcomes of hearing help-seekers: A self-determination theory perspective.* Int J Audiol. 2016 Jan 11;:1-10 Authors: Ridgway J, Hickson L, Lind C Abstract OBJECTIVE: To explore the explanatory power of a self-determination theory (SDT) model of health behaviour change for hearing aid adoption decisions and fitting outcomes. DESIGN: A quantitative approach was taken for this longitudinal cohort study. Participants completed questionnaires adapted from SDT that measured autonomous motivation, autonomy support, and perceived competence for hearing aids. Hearing ... περισσότερα »
Initial classification of pediatric hearing impairment using behavioral measures of early prelingual auditory development.
*Initial classification of pediatric hearing impairment using behavioral measures of early prelingual auditory development.* Int J Audiol. 2016 Jan 11;:1-8 Authors: Liang S, Soli SD, Zheng Y, Li G, Meng Z Abstract OBJECTIVE: Determine the sensitivity, specificity, and accuracy of pediatric hearing loss classification using behavioral evidence of early prelingual auditory development (EPLAD). Validate behavioral measures of EPLAD. DESIGN: EPLAD was assessed in a prospective sample of hearing-impaired children using the infant-toddler meaningful auditory integration scale (ITMAIS/M... περισσότερα »
Decision-making and outcomes of hearing help-seekers: A self-determination theory perspective.
*Decision-making and outcomes of hearing help-seekers: A self-determination theory perspective.* Int J Audiol. 2016 Jan 11;:1-10 Authors: Ridgway J, Hickson L, Lind C Abstract OBJECTIVE: To explore the explanatory power of a self-determination theory (SDT) model of health behaviour change for hearing aid adoption decisions and fitting outcomes. DESIGN: A quantitative approach was taken for this longitudinal cohort study. Participants completed questionnaires adapted from SDT that measured autonomous motivation, autonomy support, and perceived competence for hearing aids. Hearing... περισσότερα »
Initial classification of pediatric hearing impairment using behavioral measures of early prelingual auditory development.
*Initial classification of pediatric hearing impairment using behavioral measures of early prelingual auditory development.* Int J Audiol. 2016 Jan 11;:1-8 Authors: Liang S, Soli SD, Zheng Y, Li G, Meng Z Abstract OBJECTIVE: Determine the sensitivity, specificity, and accuracy of pediatric hearing loss classification using behavioral evidence of early prelingual auditory development (EPLAD). Validate behavioral measures of EPLAD. DESIGN: EPLAD was assessed in a prospective sample of hearing-impaired children using the infant-toddler meaningful auditory integration scale (ITMAIS/... περισσότερα »
Simulation-based otolaryngology - head and neck surgery boot camp: 'how I do it'.
*Simulation-based otolaryngology - head and neck surgery boot camp: 'how I do it'.* J Laryngol Otol. 2016 Jan 11;:1-7 Authors: Chin CJ, Chin CA, Roth K, Rotenberg BW, Fung K Abstract BACKGROUND: In otolaryngology, surgical emergencies can occur at any time. An annual surgical training camp (or 'boot camp') offers junior residents from across North America the opportunity to learn and practice these skills in a safe environment. The goals of this study were to describe the set-up and execution of a simulation-based otolaryngology boot camp and to determine participants' confidenc... περισσότερα »
Mucosal Melanoma: Epidemiology, Biology and Treatment.
[image: http:--production.springer.de-OnlineReso] Related Articles *Mucosal Melanoma: Epidemiology, Biology and Treatment.* Cancer Treat Res. 2016;167:295-320 Authors: Spencer KR, Mehnert JM Abstract Mucosal melanoma is an exceedingly rare variant of cutaneous melanoma that, due to its rarity, is poorly described and infrequently studied. Primary sites of origin include the head and neck, anorectum and vulvovaginal regions. It is uniquely different from cutaneous melanoma with respect to epidemiology, etiology, pathogenesis and prognosis. The etiology and pathogenesis remain uncl... περισσότερα »
The impact of laronidase treatment in otolaryngological manifestations of patients with mucopolysaccharidosis.
*The impact of laronidase treatment in otolaryngological manifestations of patients with mucopolysaccharidosis.* Braz J Otorhinolaryngol. 2015 Dec 17; Authors: Dualibi AP, Martins AM, Moreira GA, de Azevedo MF, Fujita RR, Pignatari SS Abstract INTRODUCTION: Mucopolysaccharidosis (MPS) is a lysosomal storage disease caused by deficiency of α-l-iduronidase. The otolaryngological findings include hearing loss, otorrhea, recurrent otitis, hypertrophy of tonsils and adenoid, recurrent rhinosinusitis, speech disorders, snoring, oral breathing and nasal obstruction. OBJECTIVE: To evalu...περισσότερα »
Impact of adenotonsillectomy on vocal emission in children.
*Impact of adenotonsillectomy on vocal emission in children.* Braz J Otorhinolaryngol. 2015 Dec 14; Authors: Dimatos SC, Neves LR, Beltrame JM, Azevedo RR, Pignatari SS Abstract INTRODUCTION: Adenotonsillectomy is the most common surgery performed by otolaryngologists in pediatric age, and one of the most frequently asked questions about the postoperative period is whether there is a potential for change in vocal pattern of these children. OBJECTIVE: To evaluate the impact of adenotonsillectomy in the voice emission pattern of children with hypertrophy of palatine and pharyngeal ...περισσότερα »
TERT promoter mutations are a rare event in gastrointestinal stromal tumors.
*TERT promoter mutations are a rare event in gastrointestinal stromal tumors.* Springerplus. 2015;4:836 Authors: Akaike K, Toda-Ishii M, Suehara Y, Mukaihara K, Kubota D, Mitani K, Takagi T, Kaneko K, Yao T, Saito T Abstract Recently, the impact of telomere dysregulation on malignant progression has been reported in many cancers. A few studies have examined TERT promoter mutations in gastrointestinal stromal tumors (GISTs). Irregular telomerase activation can be maintained by TERT hot spot alterations and alternative lengthening of telomeres (ALT) characterized by inactivation o...περισσότερα »
[Therapeutic Effect and Tolerance of Ipilimumam in Metastatic Malignant Melanoma in Children - a Case Report].
[image: http:--http://ift.tt/1S97DOs] Related Articles *[Therapeutic Effect and Tolerance of Ipilimumam in Metastatic Malignant Melanoma in Children - a Case Report].* Klin Onkol. 2015;28 Suppl 4:4S115-20 Authors: Bajčiová V Abstract BACKGROUND: Malignant melanoma is a rare malignancy in the pediatric population. Etiology is usually unknown. Clinical symptoms are nonspecific, clinical behavior and biology features may differ from those in an adult population. The most important prognostic factor is spread of disease. Surgical resection is treatment of choice for localized melanom...περισσότερα »
Acral Lentiginous Melanoma.
[image: http:--production.springer.de-OnlineReso] Related Articles *Acral Lentiginous Melanoma.* Cancer Treat Res. 2016;167:321-9 Authors: Goydos JS, Shoen SL Abstract Acral lentiginous melanoma (ALM) is a rare subtype of melanoma mainly arising on the palms, soles, and nail beds. ALM is the most common subtype of melanoma found in patients of Asian or African descent and tends to more advanced at presentation due to delays in diagnosis. Surgical treatment is difficult owing to the complexity and functional importance of the hands and feet and reconstruction after resection is us...περισσότερα »
[Progress in the molecular genetic mechanism of gonadoblastoma].
Related Articles *[Progress in the molecular genetic mechanism of gonadoblastoma].* Yi Chuan. 2015 Nov;37(11):1105-15 Authors: Lili Y, Wanru D, Minghui C, Xiangyang K Abstract Gonadoblastoma (GB), a rare in situ germ cell tumor derived from sex cord and germ cells, is closely associated with gonadal dysgenesis. About 80% of GB individuals exhibit 46, XY female phenotype while the others are 45, XY and 46, XX with disorders of sex development. Moreover, 35% of GB can eventually develop into malignant tumors, such as seminoma and dysgerminoma tumors. The molecular genetic mechanism... περισσότερα »
Management of Squamous Cancer Metastatic to Cervical Nodes With an Unknown Primary Site.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Management of Squamous Cancer Metastatic to Cervical Nodes With an Unknown Primary Site.* J Clin Oncol. 2015 Oct 10;33(29):3328-37 Authors: Galloway TJ, Ridge JA Abstract Squamous cell carcinoma of an unknown primary (SCCUP) of the head and neck is a rare disease. As a diagnosis of exclusion, the manner in which it is assigned merits consideration. Despite the development and refinement of several techniques designed to locate an occult tumor, including cross-sectional anatomic imaging, functional imaging, and tr...περισσότερα »
Nonmelanoma Cutaneous Head and Neck Cancer and Merkel Cell Carcinoma: Current Concepts, Advances, and Controversies.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Nonmelanoma Cutaneous Head and Neck Cancer and Merkel Cell Carcinoma: Current Concepts, Advances, and Controversies.* J Clin Oncol. 2015 Oct 10;33(29):3338-45 Authors: Porceddu SV, Veness MJ, Guminski A Abstract Nonmelanoma skin cancer (NMSC) is the most common cancer worldwide and the most frequently observed malignancy in whites. Approximately 75% to 80% are basal cell carcinomas and 20% to 25% are squamous cell carcinomas. Incidence is increasing, partly reflecting an ageing population, and NMSC is more common... περισσότερα »
Radiotherapy after mastectomy for screen-detected ductal carcinoma in situ.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Radiotherapy after mastectomy for screen-detected ductal carcinoma in situ.* Eur J Surg Oncol. 2015 Oct;41(10):1406-10 Authors: Clements K, Dodwell D, Lawrence G, Ball G, Francis A, Pinder S, Sawyer E, Wallis M, Thompson AM, Sloane Project Steering Group Abstract BACKGROUND: A role for radiotherapy after mastectomy for ductal carcinoma in situ (DCIS) is unclear. Using a prospective audit of DCIS detected through the NHS Breast Screening Programme we sought to determine a rationale for the use of post mastectomy r... περισσότερα »
Professional risks when carrying out cytoreductive surgery for peritoneal malignancy with hyperthermic intraperitoneal chemotherapy (HIPEC): A French multicentric survey.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Professional risks when carrying out cytoreductive surgery for peritoneal malignancy with hyperthermic intraperitoneal chemotherapy (HIPEC): A French multicentric survey.* Eur J Surg Oncol. 2015 Oct;41(10):1361-7 Authors: Ferron G, Simon L, Guyon F, Glehen O, Goere D, Elias D, Pocard M, Gladieff L, Bereder JM, Brigand C, Classe JM, Guilloit JM, Quenet F, Abboud K, Arvieux C, Bibeau F, De Chaisemartin C, Delroeux D, Durand-Fontanier S, Goasguen N, Gouthi L, Heyd B, Kianmanesh R, Leblanc E, Loi V, Lorimier G, March...περισσότερα »
Synchronous Subarachnoid Aneurysmal Hemorrhage and Medulloblastoma in a 6-Year-Old Girl.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Synchronous Subarachnoid Aneurysmal Hemorrhage and Medulloblastoma in a 6-Year-Old Girl.* World Neurosurg. 2015 Oct;84(4):1176.e11-4 Authors: Foley RW, Ndoro S, Crimmins D, Caird J Abstract BACKGROUND: Hemorrhage in medulloblastoma (MB) is a rare clinical entity with the undeniable potential for catastrophic repercussions. This case report highlights the first incidence of intraoperative subarachnoid hemorrhage (SAH) in a patient with MB secondary to an intracranial aneurysm. CASE DESCRIPTION: A 6-year-old girl wi... περισσότερα »
Primary Central Nervous System Natural Killer Cell Lymphoma in a Chinese Woman with Atypical (11)C-Choline Positron Emission Tomography and Magnetic Resonance Spectrometry Findings.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Primary Central Nervous System Natural Killer Cell Lymphoma in a Chinese Woman with Atypical (11)C-Choline Positron Emission Tomography and Magnetic Resonance Spectrometry Findings.* World Neurosurg. 2015 Oct;84(4):1176.e5-9 Authors: Li LF, Taw BB, Pu JK, Hwang GY, Lui WM, Leung GK Abstract BACKGROUND: Primary central nervous system (CNS) natural killer (NK)-cell lymphoma is rare with only 7 cases reported previously. Magnetic resonance spectroscopy (MRS) and [(18)F]fluorodeoxyglucose (FDG) positron emission tomo... περισσότερα »
Review: New diagnostic and therapeutic avenues for mesothelioma.
Related Articles *Review: New diagnostic and therapeutic avenues for mesothelioma.* Pak J Pharm Sci. 2015 Jul;28(4):1425-32 Authors: Paracha UZ, Hayat K, Ali M, Qadir MI Abstract Mesothelioma is a rare form of cancer affecting the mesothelium lining. It is usually caused by asbestos exposure or exposure to nanofibers. Median survival is less than one year in the mesothelioma patients. Due to its severity, there is a dire necessity to find out new diagnostic and therapeutic strategies. Some recent strategies could help us in fighting against mesothelioma. Diagnostic tools include ...περισσότερα »
Solitary Metastasis to the Facial/Vestibulocochlear Nerve Complex: Case Report and Review of the Literature.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Solitary Metastasis to the Facial/Vestibulocochlear Nerve Complex: Case Report and Review of the Literature.* World Neurosurg. 2015 Oct;84(4):1178.e15-8 Authors: Ariai MS, Eggers SD, Giannini C, Driscoll CL, Link MJ Abstract BACKGROUND: Distant metastasis of mucinous adenocarcinoma from the gastrointestinal tract, ovaries, pancreas, lungs, breast, or urogenital system is a well-described entity. Mucinous adenocarcinomas from different primary sites are histologically identical with gland cells producing a copious... περισσότερα »
Childhood Hepatosplenic T-cell Lymphoma with Skin Involvement.
[image: http:--http://ift.tt/1PTYrwI.] Related Articles *Childhood Hepatosplenic T-cell Lymphoma with Skin Involvement.* Indian Pediatr. 2015 May;52(5):427-8 Authors: Guo X, Li Q, Zhu YP Abstract BACKGROUND: Hepatosplenic T-cell lymphoma is a rare malignancy in childhood. CASE CHARACTERISTICS: A 12-year-old boy who presented a pyrexia of unknown origin, multiple skin and lesions and marked hepatosplenomegaly. OBSERVATION: Bone marrow aspirate cytology showed no blast cells. Splenectomy was done, and spleen showed infiltration with atypical lymphoid cells positive for CD3, CD8 and T... περισσότερα »
Bladder and gastric metastases from lung adenocarcinoma harboring codon 13 KRAS mutation: a case report with unusual clinical outcome.
[image: http:--http://ift.tt/1SLHBms] Related Articles *Bladder and gastric metastases from lung adenocarcinoma harboring codon 13 KRAS mutation: a case report with unusual clinical outcome.* Tumori. 2015 Sep-Oct;101(5):e138-40 Authors: Galetta D, Catino A, Misino A, De Ceglie A, Logroscino A, Simone G, Natalicchio MI Abstract AIMS AND BACKGROUND: Gastric and bladder metastases are rare in non-small-cell lung cancer (NSCLC) and the differential diagnosis with primary tumors requires an in-depth examination. KRAS gene mutations are the main oncogenic driver of lung adenocarcinoma ...περισσότερα »
Long-term survival in metastasized leiomyosarcoma: a case report and review of the literature.
[image: http:--http://ift.tt/1SLHBms] Related Articles *Long-term survival in metastasized leiomyosarcoma: a case report and review of the literature.* Tumori. 2015 Sep-Oct;101(5):e141-4 Authors: Schönknecht C, Hadjamu M, Oechsner M, Andratschke N, Duma MN Abstract BACKGROUND: Leiomyosarcoma of the mesosigma is a very rare entity, with low 5-year survival rates. Treatment consists of resection of the primary tumor and, if applicable, of synchronous or metachronous metastases. Local treatment options for metastatic disease should be exploited as long as possible, as response to ch...περισσότερα »
Neutropenia secondary to exposure to levetiracetam.
[image: http:--http://ift.tt/1SLHBms] Related Articles *Neutropenia secondary to exposure to levetiracetam.* Tumori. 2015 Sep-Oct;101(5):e145-6 Authors: Taberner Bonastre MT, Peralta Muñoz S, Boza FM, Gumà I Padró J Abstract AIMS AND BACKGROUND: Brain metastases occur in about 30% of patients with non-small-cell lung carcinoma; seizures occur in approximately 20% of them. Antiepileptic drugs are commonly given for postoperative prophylaxis after brain or metastasis tumor surgery. The incidence of seizures following supratentorial craniotomy is estimated to be 15%-20%. Postoperativ...περισσότερα »
Complications Following Stereotactic Needle Biopsy of Intracranial Tumors.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Complications Following Stereotactic Needle Biopsy of Intracranial Tumors.* World Neurosurg. 2015 Oct;84(4):1084-9 Authors: Malone H, Yang J, Hershman DL, Wright JD, Bruce JN, Neugut AI Abstract BACKGROUND: Data from single-institution studies suggest that perioperative complication rates after stereotactic needle brain biopsies range from 6% to 12%, with permanent morbidity and mortality ranging from 3.1% to 6.4% and 0% to 1.7%, respectively. However, no population-level data are available. We conducted a populat... περισσότερα »
Tetra-ataxiometric Posturography in Patients with Migrainous Vertigo.
*Tetra-ataxiometric Posturography in Patients with Migrainous Vertigo.* Pain Physician. 2016 Jan;19(1):E87-E96 Authors: Ongun N, Atalay NS, Degirmenci E, Sahin F, Bir LS Abstract BACKGROUND: Migraine is a common disorder characterized by headache attacks frequently accompanied by vestibular symptoms like dizziness, vertigo, and balance disorders. Clinical studies support a strong link between migraine and vertigo rather than between other headache types and vertigo or nonvertiginous dizziness. There is a lack of consensus regarding the pathophysiology of migrainous vertigo. Activ... περισσότερα »
Vestibular neuritis: Evaluation and effect of vestibular rehabilitation.
*Vestibular neuritis: Evaluation and effect of vestibular rehabilitation.* Rev Laryngol Otol Rhinol (Bord). 2015;136(1):21-7 Authors: Lorin P, Donnard M, Foubert F Abstract UNLABELLED: Vestibular neuritis (VN) is a caloric vestibular areflexia that occurs suddenly, and whose compensation can take several weeks, sometimes several months. Usually these patients are rehabilitated, but the most affected patients (cervical vestibular evoked myogenic potential (cVEMP) absent) have a worse prognosis of vestibulo-ocular compensation. Thanks to symptomatic, videographic and posturographic... περισσότερα »
Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder.
*Natural Products for the Prevention and Treatment of Hangover and Alcohol Use Disorder.* Molecules. 2016;21(1) Authors: Wang F, Li Y, Zhang YJ, Zhou Y, Li S, Li HB Abstract Alcoholic beverages such as beer, wine and spirits are widely consumed around the world. However, alcohol and its metabolite acetaldehyde are toxic and harmful to human beings. Chronic alcohol use disorder or occasional binge drinking can cause a wide range of health problems, such as hangover, liver damage and cancer. Some natural products such as traditional herbs, fruits, and vegetables might be potential...περισσότερα »
Evaluation of transforming growth factor-β2 for radiation-induced diarrhea after pelvic radiotherapy.
[image: http:--http://ift.tt/1SLHBms] Related Articles *Evaluation of transforming growth factor-β2 for radiation-induced diarrhea after pelvic radiotherapy.* Tumori. 2015 Sep-Oct;101(5):474-7 Authors: Demiral S, Beyzadeoglu M, Sager O, Dincoglan F, Uysal B, Gamsiz H, Akin M, Turker T Abstract AIMS AND BACKGROUND: Radiotherapy (RT) plays a central role in the management of cancers located in the abdomen and pelvis. However, radiation-induced toxicity remains a major concern for patients receiving RT to the abdominopelvic region. In this context, our study aims to evaluate the us...περισσότερα »
Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE study.
[image: http:--production.springer.de-OnlineReso] Related Articles *Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE study.* Cancer Causes Control. 2014 Oct;25(10):1283-93 Authors: Ajrouche R, Rudant J, Orsi L, Petit A, Baruchel A, Nelken B, Pasquet M, Michel G, Bergeron C, Ducassou S, Gandemer V, Lutz P, Saumet L, Rialland X, Hémon D, Clavel J Abstract PURPOSE: To investigate the potential involvement of fertility treatments and other conditions of becoming pregnant (infertility, getting pregna...περισσότερα »
Immunobullous disease and ulcerative colitis: the need of an accurate diagnosis
Abstract In their paper entitled ''Immunobullous disease and ulcerative colitis: a case series of six patients", Sotiriou *and cols*1 describe six patients with different immunobullous diseases and concomitant ulcerative colitis. In case 1, linear IgA bullous dermatosis (LABD) diagnosis was made exclusively by histopathologic and direct immunofluorescence findings. This article is protected by copyright. All rights reserved. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1l2Abh8 via IFTTT
Reply to: Validation of database search strategies for the epidemiological study of pemphigus and pemphigoid: reply from authors
Abstract We read the response to our manuscript 1 by Professor Langan and group 2. Indeed, not *all* studies have been limited to single centers with smaller cohorts. We were aware of their excellent studies of pemphigus and pemphigoid and certainly did not mean to ignore them. The studies of Langan et al. were performed in a unique clinical database that used Read codes, which are standard in UK general practice. This article is protected by copyright. All rights reserved. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1J0liHM via IFTTT
Impact of delay in diagnosis in outcomes in MEN1: results from the Dutch MEN1 study group.
*Impact of delay in diagnosis in outcomes in MEN1: results from the Dutch MEN1 study group.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153766 Authors: van Leeuwaarde RS, van Nesselrooij BP, Hermus AR, Dekkers OM, de Herder WW, van der Horst-Schrivers AN, Drent ML, Bisschop PH, Havekes B, Vriens MR, de Laat JM, Pieterman CR, Valk GD Abstract OBJECTIVE: Identifying a germline mutation in the MEN1 gene in an index case has consequences for a whole family. Eligible family members should be offered genetic counseling and MEN1 mutation testing. Subsequently clinical screening of mutat... περισσότερα »
Single-Dose Study of a Corticotropin-Releasing Factor Receptor-1 Antagonist in Women with 21-Hydroxylase Deficiency.
*Single-Dose Study of a Corticotropin-Releasing Factor Receptor-1 Antagonist in Women with 21-Hydroxylase Deficiency.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153574 Authors: Turcu AF, Spencer-Segal JL, Farber RH, Luo R, Grigoriadis DE, Ramm CA, Madrigal D, Muth T, O'Brien CF, Auchus RJ Abstract CONTEXT: Treatment of 21-hydroxylase deficiency (21OHD) is difficult to optimize. Normalization of excessive adrenocorticotropin (ACTH) and adrenal steroid production commonly requires supraphysiologic doses of glucocorticoids. OBJECTIVES: We evaluated the safety and tolerability of the... περισσότερα »
Robust Thyroid Gene Expression and Radioiodine Uptake Induced by Simultaneous Suppression of BRAF V600E and Histone Deacetylase in Thyroid Cancer Cells.
*Robust Thyroid Gene Expression and Radioiodine Uptake Induced by Simultaneous Suppression of BRAF V600E and Histone Deacetylase in Thyroid Cancer Cells.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20153433 Authors: Cheng W, Liu R, Zhu G, Wang H, Xing M Abstract Context Use of BRAF V600E inhibitors to restore thyroid iodide-handing gene expression and radioactive iodine (RAI) avidity is an attractive therapeutic strategy for RAI-refractory thyroid cancer, but recent initial clinical responses were modest. Given histone deacetylation at the sodium/iodide symporter (NIS) promoter by ...περισσότερα »
Androgen-induced relaxation of uterine myocytes is mediated by blockade of both Ca(2+) flux and MLC phosphorylation.
*Androgen-induced relaxation of uterine myocytes is mediated by blockade of both Ca(2+) flux and MLC phosphorylation.* J Clin Endocrinol Metab. 2016 Jan 11;:jc20152851 Authors: Makieva S, Hutchinson LJ, Rajagopal SP, Rinaldi SF, Brown P, Saunders PT, Norman JE Abstract CONTEXT: Uterine quiescence must be maintained until pregnancy reaches term. Premature activation of myometrial contractility leads to preterm labour and delivery. OBJECTIVE: To scrutinise the potential of androgens to relax the myometrium and the mechanism of their action. SAMPLES: A pregnancy-derived myometrial s...περισσότερα »
Histological verification of the prehypogastric and ovarian ganglia confirms a bilaterally symmetrical organization of the ganglia comprising the aortic plexus in female human cadavers.
*Histological verification of the prehypogastric and ovarian ganglia confirms a bilaterally symmetrical organization of the ganglia comprising the aortic plexus in female human cadavers.* J Anat. 2016 Jan 11; Authors: Beveridge TS, Johnson M, Power NE, Allman BL Abstract The aortic plexus is a network of sympathetic nerves positioned along the infrarenal abdominal aorta. Recently, we characterized the aortic plexus and its ganglia (inferior mesenteric, left/right spermatic, and prehypogastric ganglion) in males; however, the literature minimally describes its anatomy in females.... περισσότερα »
Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective.* J Clin Oncol. 2015 Oct 10;33(29):3356-64 Authors: Lee AW, Ma BB, Ng WT, Chan AT Abstract Nasopharyngeal carcinoma of the undifferentiated subtype is endemic to southern China, and patient prognosis has improved significantly over the past three decades because of advances in disease management, diagnostic imaging, radiotherapy technology, and broader application of systemic therapy. Despite the excellent local control with modern ra...περισσότερα »
Oral Cavity Carcinoma: Current Management, Controversies, and Future Directions.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Oral Cavity Carcinoma: Current Management, Controversies, and Future Directions.* J Clin Oncol. 2015 Oct 10;33(29):3269-76 Authors: Chinn SB, Myers JN Abstract Oral cavity carcinoma (OCC) remains a major cause of morbidity and mortality in patients with head and neck cancer. Although the incidence has decreased over the last decade, outcomes remain stagnant with only a 5% improvement in overall survival in the last 20 years. Although surgical resection remains the primary treatment modality, several areas of con... περισσότερα »
New Genetic and Genomic Approaches After the Genome-wide Association Study Era--Back to the Future.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *New Genetic and Genomic Approaches After the Genome-wide Association Study Era--Back to the Future.* Gastroenterology. 2015 Oct;149(5):1138-41 Authors: Ngeow J, Eng C Abstract Identification of all human genes and their regulatory regions provides the essential framework for our understanding of the molecular basis of disease. There is a lot of enthusiasm for applying next-generation sequencing methods toward achieving the goals of precision medicine. To do so will require us to go beyond genomics and fundamental... περισσότερα »
Evaluation of transforming growth factor-β2 for radiation-induced diarrhea after pelvic radiotherapy.
[image: http:--http://ift.tt/1SLHBms] Related Articles *Evaluation of transforming growth factor-β2 for radiation-induced diarrhea after pelvic radiotherapy.* Tumori. 2015 Sep-Oct;101(5):474-7 Authors: Demiral S, Beyzadeoglu M, Sager O, Dincoglan F, Uysal B, Gamsiz H, Akin M, Turker T Abstract AIMS AND BACKGROUND: Radiotherapy (RT) plays a central role in the management of cancers located in the abdomen and pelvis. However, radiation-induced toxicity remains a major concern for patients receiving RT to the abdominopelvic region. In this context, our study aims to evaluate the us...περισσότερα »
The impact of laronidase treatment in otolaryngological manifestations of patients with mucopolysaccharidosis.
*The impact of laronidase treatment in otolaryngological manifestations of patients with mucopolysaccharidosis.* Braz J Otorhinolaryngol. 2015 Dec 17; Authors: Dualibi AP, Martins AM, Moreira GA, de Azevedo MF, Fujita RR, Pignatari SS Abstract INTRODUCTION: Mucopolysaccharidosis (MPS) is a lysosomal storage disease caused by deficiency of α-l-iduronidase. The otolaryngological findings include hearing loss, otorrhea, recurrent otitis, hypertrophy of tonsils and adenoid, recurrent rhinosinusitis, speech disorders, snoring, oral breathing and nasal obstruction. OBJECTIVE: To evalu...περισσότερα »
Impact of adenotonsillectomy on vocal emission in children.
*Impact of adenotonsillectomy on vocal emission in children.* Braz J Otorhinolaryngol. 2015 Dec 14; Authors: Dimatos SC, Neves LR, Beltrame JM, Azevedo RR, Pignatari SS Abstract INTRODUCTION: Adenotonsillectomy is the most common surgery performed by otolaryngologists in pediatric age, and one of the most frequently asked questions about the postoperative period is whether there is a potential for change in vocal pattern of these children. OBJECTIVE: To evaluate the impact of adenotonsillectomy in the voice emission pattern of children with hypertrophy of palatine and pharyngeal ...περισσότερα »
Vestibular Function and Activities of Daily Living: Analysis of the 1999 to 2004 National Health and Nutrition Examination Surveys.
*Vestibular Function and Activities of Daily Living: Analysis of the 1999 to 2004 National Health and Nutrition Examination Surveys.* Gerontol Geriatr Med. 2015 Jan-Dec;1 Authors: Harun A, Semenov YR, Agrawal Y Abstract OBJECTIVE: Vestibular dysfunction increases with age and is associated with mobility difficulties and fall risk in older individuals. We evaluated whether vestibular function influences the ability to perform activities of daily living (ADLs). METHOD: We analyzed the 1999 to 2004 National Health and Nutrition Examination Survey of adults aged older than 40 years (... περισσότερα »
Retrospective Clinical Study of Eighty-One Cases of Intracranial Mucormycosis.
*Retrospective Clinical Study of Eighty-One Cases of Intracranial Mucormycosis.* J Glob Infect Dis. 2015 Oct-Dec;7(4):143-150 Authors: Ma J, Jia R, Li J, Liu Y, Li Y, Lin P, Zhang M, Li M Abstract BACKGROUND: Fungal infections of the central nervous system, especially cerebral mucormycosis or brain abscess are very rare.Cerebral mucormycosis is a rare disease. It is not an independent disease, but a secondary opportunistic infectious disease. MATERIALS AND METHODS: This study has collected the data of 81 cases of intracranial mucormycosis from 28 Chinese hospitals, within 37 year...περισσότερα »
The age dependence of T2 relaxation times of N-acetyl aspartate, creatine and choline in the human brain at 3 and 4T.
*The age dependence of T2 relaxation times of N-acetyl aspartate, creatine and choline in the human brain at 3 and 4T.* NMR Biomed. 2016 Jan 11; Authors: Jiru F, Skoch A, Wagnerova D, Dezortova M, Viskova J, Profant O, Syka J, Hajek M Abstract Knowledge of the T2 age dependence is of importance for MRS clinical studies involving subject groups with a wide age range. A number of studies have focused on the age dependence of T2 values in the human brain, with rather conflicting results. The aim of this study was to analyze the age dependence of T2 values of N-acetyl aspartate (NAA... περισσότερα »
Children perceive speech onsets by ear and eye.
*Children perceive speech onsets by ear and eye.* J Child Lang. 2016 Jan 11;:1-31 Authors: Jerger S, Damian MF, Tye-Murray N, Abdi H Abstract Adults use vision to perceive low-fidelity speech; yet how children acquire this ability is not well understood. The literature indicates that children show reduced sensitivity to visual speech from kindergarten to adolescence. We hypothesized that this pattern reflects the effects of complex tasks and a growth period with harder-to-utilize cognitive resources, not lack of sensitivity. We investigated sensitivity to visual speech in childre... περισσότερα »
Human epidermal growth factor receptor 2/neu as a novel therapeutic target in sinonasal undifferentiated carcinoma.
*Human epidermal growth factor receptor 2/neu as a novel therapeutic target in sinonasal undifferentiated carcinoma.* Head Neck. 2016 Jan 11; Authors: Takahashi Y, Lee J, Pickering C, Bell D, Jiffar TW, Myers JN, Hanna EY, Kupferman ME Abstract BACKGROUND: Sinonasal undifferentiated carcinoma (SNUC) is a rare and aggressive cancer. Despite multimodal therapy, the prognosis in SNUC remains poor, and new therapies are needed. Thus, the purpose of this study was to explore potential therapeutic targets in SNUC. METHODS: Using the human-derived SNUC MDA8788-6 cell line, we performed ... περισσότερα »
Assessment of functional outcomes of temporalis muscle transfers for patients with longstanding facial paralysis.
*Assessment of functional outcomes of temporalis muscle transfers for patients with longstanding facial paralysis.* Head Neck. 2016 Jan 11; Authors: Scaglioni MF, Verdini F, Marchesini A, Neuendorf AD, Coccia D, Leo T, Riccio M Abstract BACKGROUND: Usually, clinical evaluation of facial reanimation provides accurate information about contraction of the mimetic muscles and phonation but fails to identify smile recovery and to quantify the motility of the lower third of the face during a smile. The purpose of this study was to verify that, in longstanding facial palsy, the modifie... περισσότερα »
Early Arising Sarcoma After Adjuvant Radiotherapy for Oral Squamous Cell Carcinoma.
*Early Arising Sarcoma After Adjuvant Radiotherapy for Oral Squamous Cell Carcinoma.* J Oral Maxillofac Surg. 2015 Dec 12; Authors: Marchitto G, Marci V, Berrone M, Pentenero M Abstract Radiation-induced sarcoma of the head and neck (RISHN) is a rare and long-term complication of radiation therapy (RT). This report describes a case of RISHN characterized by early and insidious onset. An 80-year-old man was surgically treated for advanced oral squamous cell carcinoma of the left retromolar trigone (pT4aN0). Sixteen months after completion of adjuvant RT, an exophytic sessile lesi... περισσότερα »
Cell-Specific Cre Strains For Genetic Manipulation in Salivary Glands.
*Cell-Specific Cre Strains For Genetic Manipulation in Salivary Glands.* PLoS One. 2016;11(1):e0146711 Authors: Maruyama EO, Aure MH, Xie X, Myal Y, Gan L, Ovitt CE Abstract The secretory acinar cells of the salivary gland are essential for saliva secretion, but are also the cell type preferentially lost following radiation treatment for head and neck cancer. The source of replacement acinar cells is currently a matter of debate. There is evidence for the presence of adult stem cells located within specific ductal regions of the salivary glands, but our laboratory recently demons... περισσότερα »
Treatment of severe refractory epistaxis in hereditary hemorrhagic telangiectasia using a two-flap nasal closure method.
*Treatment of severe refractory epistaxis in hereditary hemorrhagic telangiectasia using a two-flap nasal closure method.* Int Forum Allergy Rhinol. 2016 Jan 11; Authors: Timmins BH, Hunter BN, Wilson KF, Ward PD Abstract BACKGROUND: Nasal closure has been shown to effectively manage severe epistaxis refractory to other treatments in patients with hereditary hemorrhagic telangiectasia (HHT). The nasal closure procedure may be underutilized because of its surgical complexity and flap breakdown. METHODS: This work is a retrospective review of 13 HHT patients treated for severe epis...περισσότερα »
Preclinical Activity of the Vascular Disrupting Agent OXi4503 against Head and Neck Cancer.
*Preclinical Activity of the Vascular Disrupting Agent OXi4503 against Head and Neck Cancer.* Cancers (Basel). 2016;8(1) Authors: Bothwell KD, Folaron M, Seshadri M Abstract Vascular disrupting agents (VDAs) represent a relatively distinct class of agents that target established blood vessels in tumors. In this study, we examined the preclinical activity of the second-generation VDA OXi4503 against human head and neck squamous cell carcinoma (HNSCC). Studies were performed in subcutaneous and orthotopic FaDu-luc HNSCC xenografts established in immunodeficient mice. In the subcut... περισσότερα »
Association between UGT1A1 Polymorphism and Risk of Laryngeal Squamous Cell Carcinoma.
*Association between UGT1A1 Polymorphism and Risk of Laryngeal Squamous Cell Carcinoma.* Int J Environ Res Public Health. 2016;13(1) Authors: Huangfu H, Pan H, Wang B, Wen S, Han R, Li L Abstract Laryngeal cancer is one of the largest subgroups of head and neck cancers. In addition to smoking and alcohol consumption, genetic polymorphisms are also risk factors for the development of laryngeal cancer. However, the exact relation between genetic variants and pathogenesis of laryngeal cancer has remained elusive. The aim of this study was to examine UGT1A1*6 (rs4148323 A/G) polymor... περισσότερα »
A novel treatment adjunct for aspirin exacerbated respiratory disease: the low-salicylate diet: a multicenter randomized control crossover trial.
*A novel treatment adjunct for aspirin exacerbated respiratory disease: the low-salicylate diet: a multicenter randomized control crossover trial.* Int Forum Allergy Rhinol. 2016 Jan 11; Authors: Sommer DD, Rotenberg BW, Sowerby LJ, Lee JM, Janjua A, Witterick IJ, Monteiro E, Gupta MK, Au M, Nayan S Abstract BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is a clinical triad consisting of aspirin/acetylsalicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis. Although respiratory reactions following ingestion of ASA and other nonsteroidal anti-inflammato... περισσότερα »
Use of pulsed dye laser treatments in patients with vocal fold mucosal bridges with sulcus vocalis-our experience of five cases.
*Use of pulsed dye laser treatments in patients with vocal fold mucosal bridges with sulcus vocalis-our experience of five cases.* Clin Otolaryngol. 2016 Jan 11; Authors: Chang JW, Park AY, Byeon HK, Choi HS Abstract Larger and thicker mucosal bridges are usually associated with severe dysphonia, surgical excision is the currently preferred treatment. Surgical excision of mucosal bridges may decrease vocal fold bulk and result in subsequent postoperative glottal incompetence. PDL can make a cleavage plane between the epithelium and the superficial lamina propria by denaturing th...περισσότερα »
Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps.
*Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps.* Int Forum Allergy Rhinol. 2016 Jan 11; Authors: Carroll WW, Schlosser RJ, O'Connell BP, Soler ZM, Mulligan JK Abstract BACKGROUND: Vitamin D3 (VD3) is a steroid hormone with known antiproliferative properties. Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have been shown to be VD3-deficient. Moreover, VD3 deficiency is associated with worse disease in patients with CRSwNP. One cell type thought to play a role in chronic rhinos... περισσότερα »
Safety of long-term high-volume sinonasal budesonide irrigations for chronic rhinosinusitis.
*Safety of long-term high-volume sinonasal budesonide irrigations for chronic rhinosinusitis.* Int Forum Allergy Rhinol. 2016 Jan 11; Authors: Smith KA, French G, Mechor B, Rudmik L Abstract BACKGROUND: Off-label high-volume sinonasal budesonide irrigations are commonly used during the management of chronic rhinosinusitis (CRS). Although short-term use (4 to 8 weeks) has been demonstrated to be safe, the long-term effects on the hypothalamic-pituitary-adrenal (HPA) axis remain unclear. The objective of this study is to determine whether CRS patients using long-term (minimum grea...περισσότερα »
Simulation-based otolaryngology - head and neck surgery boot camp: 'how I do it'.
*Simulation-based otolaryngology - head and neck surgery boot camp: 'how I do it'.* J Laryngol Otol. 2016 Jan 11;:1-7 Authors: Chin CJ, Chin CA, Roth K, Rotenberg BW, Fung K Abstract BACKGROUND: In otolaryngology, surgical emergencies can occur at any time. An annual surgical training camp (or 'boot camp') offers junior residents from across North America the opportunity to learn and practice these skills in a safe environment. The goals of this study were to describe the set-up and execution of a simulation-based otolaryngology boot camp and to determine participants' confidenc... περισσότερα »
Impact of adenotonsillectomy on vocal emission in children.
*Impact of adenotonsillectomy on vocal emission in children.* Braz J Otorhinolaryngol. 2015 Dec 14; Authors: Dimatos SC, Neves LR, Beltrame JM, Azevedo RR, Pignatari SS Abstract INTRODUCTION: Adenotonsillectomy is the most common surgery performed by otolaryngologists in pediatric age, and one of the most frequently asked questions about the postoperative period is whether there is a potential for change in vocal pattern of these children. OBJECTIVE: To evaluate the impact of adenotonsillectomy in the voice emission pattern of children with hypertrophy of palatine and pharyngeal ...περισσότερα »
Use of pulsed dye laser treatments in patients with vocal fold mucosal bridges with sulcus vocalis-our experience of five cases.
*Use of pulsed dye laser treatments in patients with vocal fold mucosal bridges with sulcus vocalis-our experience of five cases.* Clin Otolaryngol. 2016 Jan 11; Authors: Chang JW, Park AY, Byeon HK, Choi HS Abstract Larger and thicker mucosal bridges are usually associated with severe dysphonia, surgical excision is the currently preferred treatment. Surgical excision of mucosal bridges may decrease vocal fold bulk and result in subsequent postoperative glottal incompetence. PDL can make a cleavage plane between the epithelium and the superficial lamina propria by denaturing th...περισσότερα »
[A rare and unusual cause of dysphonia: The leech].
Related Articles *[A rare and unusual cause of dysphonia: The leech].* Rev Laryngol Otol Rhinol (Bord). 2014;135(2):105-6 Authors: Abou-Elfadl M, Abada RL, Rouadi S, Mahtar M, Roubal M, Essaadi M, Janah A, Kadiri F Abstract We report a case of dysphonia associated with intermittent episodes of hemoptysis low abundance in a patient aged 32, clinical examination is normal, nasofibroscopie objective a leech at the laryngeal orifice, extracted by direct laryngoscopy in emergency. PMID: 26521350 [PubMed - indexed for MEDLINE] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/...περισσότερα »
[Transgender voice and communication treatment: Review of the literature].
Related Articles *[Transgender voice and communication treatment: Review of the literature].* Rev Laryngol Otol Rhinol (Bord). 2014;135(2):97-103 Authors: Lechien JR, Delvaux V, Huet K, Khalife M, Piccaluga M, Harmegnies B, Saussez S Abstract Transgender persons constitute a small but growing population in ENT department: as a matter of fact, many voice parameters significantly contribute to the perception of gender (fundamental frequency, supraglottic resonance patterns, etc.). The persons involved in transition processes may therefore aim at changing their own voice properties,... περισσότερα »
Iatrogenic scarring of the vocal folds after phonosurgery for benign lesions. A descriptive study of 108 patients.
Related Articles *Iatrogenic scarring of the vocal folds after phonosurgery for benign lesions. A descriptive study of 108 patients.* Rev Laryngol Otol Rhinol (Bord). 2014;135(2):57-61 Authors: Perouse AR, Coulombeau B Abstract OBJECTIVES: Patients with iatrogenic scarring of the vocal folds can present with a spectrum of dysphonia ranging from slight hoarseness to very severe dysphonia. In this paper we will describe the clinical and stroboscopic presentation of VFIS, and discuss the possibility of identifying the factors favouring such lesions. STUDY DESIGN: A retrospective cha... περισσότερα »
Decision-making and outcomes of hearing help-seekers: A self-determination theory perspective.
*Decision-making and outcomes of hearing help-seekers: A self-determination theory perspective.* Int J Audiol. 2016 Jan 11;:1-10 Authors: Ridgway J, Hickson L, Lind C Abstract OBJECTIVE: To explore the explanatory power of a self-determination theory (SDT) model of health behaviour change for hearing aid adoption decisions and fitting outcomes. DESIGN: A quantitative approach was taken for this longitudinal cohort study. Participants completed questionnaires adapted from SDT that measured autonomous motivation, autonomy support, and perceived competence for hearing aids. Hearing... περισσότερα »
Initial classification of pediatric hearing impairment using behavioral measures of early prelingual auditory development.
*Initial classification of pediatric hearing impairment using behavioral measures of early prelingual auditory development.* Int J Audiol. 2016 Jan 11;:1-8 Authors: Liang S, Soli SD, Zheng Y, Li G, Meng Z Abstract OBJECTIVE: Determine the sensitivity, specificity, and accuracy of pediatric hearing loss classification using behavioral evidence of early prelingual auditory development (EPLAD). Validate behavioral measures of EPLAD. DESIGN: EPLAD was assessed in a prospective sample of hearing-impaired children using the infant-toddler meaningful auditory integration scale (ITMAIS/... περισσότερα »
Differentiation between treatment-related changes and progressive disease in patients with high grade brain tumors using support vector machine classification based on DCE MRI
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Differentiation between treatment-related changes and progressive disease (PD) remains a major clinical challenge in the follow-up of patients with high grade brain tumors. The aim of this study was to differentiate between treatment-related changes and PD using dynamic contrast enhanced (DCE) MRI. Twenty patients were scanned using conventional, DCE-MRI and MR spectroscopy (total of […]
Mucosal Melanoma: Epidemiology, Biology and Treatment.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Related Articles Mucosal Melanoma: Epidemiology, Biology and Treatment. Cancer Treat Res. 2016;167:295-320 Authors: Spencer KR, Mehnert JM Abstract Mucosal melanoma is an exceedingly rare variant of cutaneous melanoma that, due to its rarity, is poorly described and infrequently studied. Primary sites of origin include the head and neck, anorectum and vulvovaginal regions. It is uniquely […]
The impact of laronidase treatment in otolaryngological manifestations of patients with mucopolysaccharidosis.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The impact of laronidase treatment in otolaryngological manifestations of patients with mucopolysaccharidosis. Braz J Otorhinolaryngol. 2015 Dec 17; Authors: Dualibi AP, Martins AM, Moreira GA, de Azevedo MF, Fujita RR, Pignatari SS Abstract INTRODUCTION: Mucopolysaccharidosis (MPS) is a lysosomal storage disease caused by deficiency of α-l-iduronidase. The otolaryngological findings include hearing loss, otorrhea, recurrent otitis, […]
Impact of adenotonsillectomy on vocal emission in children.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Impact of adenotonsillectomy on vocal emission in children. Braz J Otorhinolaryngol. 2015 Dec 14; Authors: Dimatos SC, Neves LR, Beltrame JM, Azevedo RR, Pignatari SS Abstract INTRODUCTION: Adenotonsillectomy is the most common surgery performed by otolaryngologists in pediatric age, and one of the most frequently asked questions about the postoperative period is whether there is […]
TERT promoter mutations are a rare event in gastrointestinal stromal tumors.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
TERT promoter mutations are a rare event in gastrointestinal stromal tumors. Springerplus. 2015;4:836 Authors: Akaike K, Toda-Ishii M, Suehara Y, Mukaihara K, Kubota D, Mitani K, Takagi T, Kaneko K, Yao T, Saito T Abstract Recently, the impact of telomere dysregulation on malignant progression has been reported in many cancers. A few studies have examined […]
Therapeutic Effect and Tolerance of Ipilimumam in Metastatic Malignant Melanoma in Children - a Case Report.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Related Articles [Therapeutic Effect and Tolerance of Ipilimumam in Metastatic Malignant Melanoma in Children - a Case Report]. Klin Onkol. 2015;28 Suppl 4:4S115-20 Authors: Bajčiová V Abstract BACKGROUND: Malignant melanoma is a rare malignancy in the pediatric population. Etiology is usually unknown. Clinical symptoms are nonspecific, clinical behavior and biology features may differ from those in an […]
Acral Lentiginous Melanoma.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Related Articles Acral Lentiginous Melanoma. Cancer Treat Res. 2016;167:321-9 Authors: Goydos JS, Shoen SL Abstract Acral lentiginous melanoma (ALM) is a rare subtype of melanoma mainly arising on the palms, soles, and nail beds. ALM is the most common subtype of melanoma found in patients of Asian or African descent and tends to more advanced […]
Progress in the molecular genetic mechanism of gonadoblastoma.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Related Articles [Progress in the molecular genetic mechanism of gonadoblastoma]. Yi Chuan. 2015 Nov;37(11):1105-15 Authors: Lili Y, Wanru D, Minghui C, Xiangyang K Abstract Gonadoblastoma (GB), a rare in situ germ cell tumor derived from sex cord and germ cells, is closely associated with gonadal dysgenesis. About 80% of GB individuals exhibit 46, XY female […]
Management of Squamous Cancer Metastatic to Cervical Nodes With an Unknown Primary Site.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Related Articles Management of Squamous Cancer Metastatic to Cervical Nodes With an Unknown Primary Site. J Clin Oncol. 2015 Oct 10;33(29):3328-37 Authors: Galloway TJ, Ridge JA Abstract Squamous cell carcinoma of an unknown primary (SCCUP) of the head and neck is a rare disease. As a diagnosis of exclusion, the manner in which it is […]
Nonmelanoma Cutaneous Head and Neck Cancer and Merkel Cell Carcinoma: Current Concepts, Advances, and Controversies.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Related Articles Nonmelanoma Cutaneous Head and Neck Cancer and Merkel Cell Carcinoma: Current Concepts, Advances, and Controversies. J Clin Oncol. 2015 Oct 10;33(29):3338-45 Authors: Porceddu SV, Veness MJ, Guminski A Abstract Nonmelanoma skin cancer (NMSC) is the most common cancer worldwide and the most frequently observed malignancy in whites. Approximately 75% to 80% are basal […]
Decision-making and outcomes of hearing help-seekers: A self-determination theory perspective.
*Decision-making and outcomes of hearing help-seekers: A self-determination theory perspective.* Int J Audiol. 2016 Jan 11;:1-10 Authors: Ridgway J, Hickson L, Lind C Abstract OBJECTIVE: To explore the explanatory power of a self-determination theory (SDT) model of health behaviour change for hearing aid adoption decisions and fitting outcomes. DESIGN: A quantitative approach was taken for this longitudinal cohort study. Participants completed questionnaires adapted from SDT that measured autonomous motivation, autonomy support, and perceived competence for hearing aids. Hearing... περισσότερα »
Initial classification of pediatric hearing impairment using behavioral measures of early prelingual auditory development.
*Initial classification of pediatric hearing impairment using behavioral measures of early prelingual auditory development.* Int J Audiol. 2016 Jan 11;:1-8 Authors: Liang S, Soli SD, Zheng Y, Li G, Meng Z Abstract OBJECTIVE: Determine the sensitivity, specificity, and accuracy of pediatric hearing loss classification using behavioral evidence of early prelingual auditory development (EPLAD). Validate behavioral measures of EPLAD. DESIGN: EPLAD was assessed in a prospective sample of hearing-impaired children using the infant-toddler meaningful auditory integration scale (ITMAIS/... περισσότερα »
Simulation-based otolaryngology - head and neck surgery boot camp: 'how I do it'.
*Simulation-based otolaryngology - head and neck surgery boot camp: 'how I do it'.* J Laryngol Otol. 2016 Jan 11;:1-7 Authors: Chin CJ, Chin CA, Roth K, Rotenberg BW, Fung K Abstract BACKGROUND: In otolaryngology, surgical emergencies can occur at any time. An annual surgical training camp (or 'boot camp') offers junior residents from across North America the opportunity to learn and practice these skills in a safe environment. The goals of this study were to describe the set-up and execution of a simulation-based otolaryngology boot camp and to determine participants' confidenc... περισσότερα »
TERT promoter mutations are a rare event in gastrointestinal stromal tumors.
*TERT promoter mutations are a rare event in gastrointestinal stromal tumors.* Springerplus. 2015;4:836 Authors: Akaike K, Toda-Ishii M, Suehara Y, Mukaihara K, Kubota D, Mitani K, Takagi T, Kaneko K, Yao T, Saito T Abstract Recently, the impact of telomere dysregulation on malignant progression has been reported in many cancers. A few studies have examined TERT promoter mutations in gastrointestinal stromal tumors (GISTs). Irregular telomerase activation can be maintained by TERT hot spot alterations and alternative lengthening of telomeres (ALT) characterized by inactivation o...περισσότερα »
[Therapeutic Effect and Tolerance of Ipilimumam in Metastatic Malignant Melanoma in Children - a Case Report].
[image: http:--http://ift.tt/1S97DOs] Related Articles *[Therapeutic Effect and Tolerance of Ipilimumam in Metastatic Malignant Melanoma in Children - a Case Report].* Klin Onkol. 2015;28 Suppl 4:4S115-20 Authors: Bajčiová V Abstract BACKGROUND: Malignant melanoma is a rare malignancy in the pediatric population. Etiology is usually unknown. Clinical symptoms are nonspecific, clinical behavior and biology features may differ from those in an adult population. The most important prognostic factor is spread of disease. Surgical resection is treatment of choice for localized melanom...περισσότερα »
Acral Lentiginous Melanoma.
[image: http:--production.springer.de-OnlineReso] Related Articles *Acral Lentiginous Melanoma.* Cancer Treat Res. 2016;167:321-9 Authors: Goydos JS, Shoen SL Abstract Acral lentiginous melanoma (ALM) is a rare subtype of melanoma mainly arising on the palms, soles, and nail beds. ALM is the most common subtype of melanoma found in patients of Asian or African descent and tends to more advanced at presentation due to delays in diagnosis. Surgical treatment is difficult owing to the complexity and functional importance of the hands and feet and reconstruction after resection is us...περισσότερα »
Mucosal Melanoma: Epidemiology, Biology and Treatment.
[image: http:--production.springer.de-OnlineReso] Related Articles *Mucosal Melanoma: Epidemiology, Biology and Treatment.* Cancer Treat Res. 2016;167:295-320 Authors: Spencer KR, Mehnert JM Abstract Mucosal melanoma is an exceedingly rare variant of cutaneous melanoma that, due to its rarity, is poorly described and infrequently studied. Primary sites of origin include the head and neck, anorectum and vulvovaginal regions. It is uniquely different from cutaneous melanoma with respect to epidemiology, etiology, pathogenesis and prognosis. The etiology and pathogenesis remain uncl... περισσότερα »
[Progress in the molecular genetic mechanism of gonadoblastoma].
Related Articles *[Progress in the molecular genetic mechanism of gonadoblastoma].* Yi Chuan. 2015 Nov;37(11):1105-15 Authors: Lili Y, Wanru D, Minghui C, Xiangyang K Abstract Gonadoblastoma (GB), a rare in situ germ cell tumor derived from sex cord and germ cells, is closely associated with gonadal dysgenesis. About 80% of GB individuals exhibit 46, XY female phenotype while the others are 45, XY and 46, XX with disorders of sex development. Moreover, 35% of GB can eventually develop into malignant tumors, such as seminoma and dysgerminoma tumors. The molecular genetic mechanism... περισσότερα »
Management of Squamous Cancer Metastatic to Cervical Nodes With an Unknown Primary Site.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Management of Squamous Cancer Metastatic to Cervical Nodes With an Unknown Primary Site.* J Clin Oncol. 2015 Oct 10;33(29):3328-37 Authors: Galloway TJ, Ridge JA Abstract Squamous cell carcinoma of an unknown primary (SCCUP) of the head and neck is a rare disease. As a diagnosis of exclusion, the manner in which it is assigned merits consideration. Despite the development and refinement of several techniques designed to locate an occult tumor, including cross-sectional anatomic imaging, functional imaging, and tr...περισσότερα »
Nonmelanoma Cutaneous Head and Neck Cancer and Merkel Cell Carcinoma: Current Concepts, Advances, and Controversies.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Nonmelanoma Cutaneous Head and Neck Cancer and Merkel Cell Carcinoma: Current Concepts, Advances, and Controversies.* J Clin Oncol. 2015 Oct 10;33(29):3338-45 Authors: Porceddu SV, Veness MJ, Guminski A Abstract Nonmelanoma skin cancer (NMSC) is the most common cancer worldwide and the most frequently observed malignancy in whites. Approximately 75% to 80% are basal cell carcinomas and 20% to 25% are squamous cell carcinomas. Incidence is increasing, partly reflecting an ageing population, and NMSC is more common... περισσότερα »
Radiotherapy after mastectomy for screen-detected ductal carcinoma in situ.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Radiotherapy after mastectomy for screen-detected ductal carcinoma in situ.* Eur J Surg Oncol. 2015 Oct;41(10):1406-10 Authors: Clements K, Dodwell D, Lawrence G, Ball G, Francis A, Pinder S, Sawyer E, Wallis M, Thompson AM, Sloane Project Steering Group Abstract BACKGROUND: A role for radiotherapy after mastectomy for ductal carcinoma in situ (DCIS) is unclear. Using a prospective audit of DCIS detected through the NHS Breast Screening Programme we sought to determine a rationale for the use of post mastectomy r... περισσότερα »
Professional risks when carrying out cytoreductive surgery for peritoneal malignancy with hyperthermic intraperitoneal chemotherapy (HIPEC): A French multicentric survey.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Professional risks when carrying out cytoreductive surgery for peritoneal malignancy with hyperthermic intraperitoneal chemotherapy (HIPEC): A French multicentric survey.* Eur J Surg Oncol. 2015 Oct;41(10):1361-7 Authors: Ferron G, Simon L, Guyon F, Glehen O, Goere D, Elias D, Pocard M, Gladieff L, Bereder JM, Brigand C, Classe JM, Guilloit JM, Quenet F, Abboud K, Arvieux C, Bibeau F, De Chaisemartin C, Delroeux D, Durand-Fontanier S, Goasguen N, Gouthi L, Heyd B, Kianmanesh R, Leblanc E, Loi V, Lorimier G, March...περισσότερα »
Synchronous Subarachnoid Aneurysmal Hemorrhage and Medulloblastoma in a 6-Year-Old Girl.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Synchronous Subarachnoid Aneurysmal Hemorrhage and Medulloblastoma in a 6-Year-Old Girl.* World Neurosurg. 2015 Oct;84(4):1176.e11-4 Authors: Foley RW, Ndoro S, Crimmins D, Caird J Abstract BACKGROUND: Hemorrhage in medulloblastoma (MB) is a rare clinical entity with the undeniable potential for catastrophic repercussions. This case report highlights the first incidence of intraoperative subarachnoid hemorrhage (SAH) in a patient with MB secondary to an intracranial aneurysm. CASE DESCRIPTION: A 6-year-old girl wi... περισσότερα »
Primary Central Nervous System Natural Killer Cell Lymphoma in a Chinese Woman with Atypical (11)C-Choline Positron Emission Tomography and Magnetic Resonance Spectrometry Findings.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Primary Central Nervous System Natural Killer Cell Lymphoma in a Chinese Woman with Atypical (11)C-Choline Positron Emission Tomography and Magnetic Resonance Spectrometry Findings.* World Neurosurg. 2015 Oct;84(4):1176.e5-9 Authors: Li LF, Taw BB, Pu JK, Hwang GY, Lui WM, Leung GK Abstract BACKGROUND: Primary central nervous system (CNS) natural killer (NK)-cell lymphoma is rare with only 7 cases reported previously. Magnetic resonance spectroscopy (MRS) and [(18)F]fluorodeoxyglucose (FDG) positron emission tomo... περισσότερα »
Review: New diagnostic and therapeutic avenues for mesothelioma.
Related Articles *Review: New diagnostic and therapeutic avenues for mesothelioma.* Pak J Pharm Sci. 2015 Jul;28(4):1425-32 Authors: Paracha UZ, Hayat K, Ali M, Qadir MI Abstract Mesothelioma is a rare form of cancer affecting the mesothelium lining. It is usually caused by asbestos exposure or exposure to nanofibers. Median survival is less than one year in the mesothelioma patients. Due to its severity, there is a dire necessity to find out new diagnostic and therapeutic strategies. Some recent strategies could help us in fighting against mesothelioma. Diagnostic tools include ...περισσότερα »
Solitary Metastasis to the Facial/Vestibulocochlear Nerve Complex: Case Report and Review of the Literature.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Solitary Metastasis to the Facial/Vestibulocochlear Nerve Complex: Case Report and Review of the Literature.* World Neurosurg. 2015 Oct;84(4):1178.e15-8 Authors: Ariai MS, Eggers SD, Giannini C, Driscoll CL, Link MJ Abstract BACKGROUND: Distant metastasis of mucinous adenocarcinoma from the gastrointestinal tract, ovaries, pancreas, lungs, breast, or urogenital system is a well-described entity. Mucinous adenocarcinomas from different primary sites are histologically identical with gland cells producing a copious... περισσότερα »
Childhood Hepatosplenic T-cell Lymphoma with Skin Involvement.
[image: http:--http://ift.tt/1PTYrwI.] Related Articles *Childhood Hepatosplenic T-cell Lymphoma with Skin Involvement.* Indian Pediatr. 2015 May;52(5):427-8 Authors: Guo X, Li Q, Zhu YP Abstract BACKGROUND: Hepatosplenic T-cell lymphoma is a rare malignancy in childhood. CASE CHARACTERISTICS: A 12-year-old boy who presented a pyrexia of unknown origin, multiple skin and lesions and marked hepatosplenomegaly. OBSERVATION: Bone marrow aspirate cytology showed no blast cells. Splenectomy was done, and spleen showed infiltration with atypical lymphoid cells positive for CD3, CD8 and T... περισσότερα »
Bladder and gastric metastases from lung adenocarcinoma harboring codon 13 KRAS mutation: a case report with unusual clinical outcome.
[image: http:--http://ift.tt/1SLHBms] Related Articles *Bladder and gastric metastases from lung adenocarcinoma harboring codon 13 KRAS mutation: a case report with unusual clinical outcome.* Tumori. 2015 Sep-Oct;101(5):e138-40 Authors: Galetta D, Catino A, Misino A, De Ceglie A, Logroscino A, Simone G, Natalicchio MI Abstract AIMS AND BACKGROUND: Gastric and bladder metastases are rare in non-small-cell lung cancer (NSCLC) and the differential diagnosis with primary tumors requires an in-depth examination. KRAS gene mutations are the main oncogenic driver of lung adenocarcinoma ...περισσότερα »
Long-term survival in metastasized leiomyosarcoma: a case report and review of the literature.
[image: http:--http://ift.tt/1SLHBms] Related Articles *Long-term survival in metastasized leiomyosarcoma: a case report and review of the literature.* Tumori. 2015 Sep-Oct;101(5):e141-4 Authors: Schönknecht C, Hadjamu M, Oechsner M, Andratschke N, Duma MN Abstract BACKGROUND: Leiomyosarcoma of the mesosigma is a very rare entity, with low 5-year survival rates. Treatment consists of resection of the primary tumor and, if applicable, of synchronous or metachronous metastases. Local treatment options for metastatic disease should be exploited as long as possible, as response to ch...περισσότερα »
Neutropenia secondary to exposure to levetiracetam.
[image: http:--http://ift.tt/1SLHBms] Related Articles *Neutropenia secondary to exposure to levetiracetam.* Tumori. 2015 Sep-Oct;101(5):e145-6 Authors: Taberner Bonastre MT, Peralta Muñoz S, Boza FM, Gumà I Padró J Abstract AIMS AND BACKGROUND: Brain metastases occur in about 30% of patients with non-small-cell lung carcinoma; seizures occur in approximately 20% of them. Antiepileptic drugs are commonly given for postoperative prophylaxis after brain or metastasis tumor surgery. The incidence of seizures following supratentorial craniotomy is estimated to be 15%-20%. Postoperativ...περισσότερα »
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