Salivary function impairment in type 2 Diabetes patients associated with concentration and genetic polymorphisms of chromogranin A
Salivary function impairment in type 2 Diabetes patients associated with concentration and genetic polymorphisms of chromogranin A: Abstract ObjectivesThe purpose of this study was to evaluate the effect of type 2 diabetes mellitus (T2DM) on salivary function impairments according to glycemic control status and subsequently compare the concentration of chromogranin A (CHGA) with its genetic profile. Materials and methodsThirty-six patients with controlled T2DM, 36 with poorly controlled T2DM, and 38 nondiabetic subjects underwent salivary flow rate measurements by means of unst...περισσότερα »
The facial nerve branching within the parotid gland
Patterns and surgical significance of facial nerve branching within the parotid gland in 43 cases: Abstract PurposeDifferent patterns of facial nerve branching within the parotid gland were detected, and these anatomical variations may affect the treatment approaches and outcomes of surgery. The aim of this study was to identify the patterns of facial nerve branching with the parotid gland and their importance in surgical procedures. Materials and methodsA total of 43 patients undergoing surgical treatments of parotid lesions were included in this study. Each patient’s demograp... περισσότερα »
Mandibular growth after paediatric mandibular reconstruction with the vascularized free fibula flap: a systematic review
Mandibular growth after paediatric mandibular reconstruction with the vascularized free fibula flap: a systematic review Abstract The reconstruction of mandibular defects with vascularized fibula flaps remains challenging in the paediatric population. The ability of the reconstructed mandible to grow remains controversial, and associated factors are unclear. A systematic search of the English-language and Chinese literature was conducted for the period January 1989 to April 2014 using selected key words associated with the topic. Individual patients aged <18 years who underwent ... περισσότερα »
Treatment of large bone defects with a novel biological transport disc in non-vascular transport distraction osteogenesis
Treatment of large bone defects with a novel biological transport disc in non-vascular transport distraction osteogenesis Abstract The aim of this study was to investigate a potential novel biological transport disc that avoids secondary injury to the body and facilitates bone healing. Twenty-seven dogs were divided randomly into three groups: group A were treated with human bone morphogenetic protein 2 (BMP-2) modified bone mesenchymal stem cell (BMSC) sheets combined with freeze-dried bone allograft as biological transport disc; group B were treated with BMSC sheets combined wi... περισσότερα »
Primary multicystic ameloblastoma
Recurrence rate following treatment for primary multicystic ameloblastoma: systematic review and meta-analysis Opinions regarding the treatment of multicystic ameloblastoma are divergent due to its benign nature and the high rate of recurrence if not adequately excised. The aim of the present study was to perform a systematic review of the literature for a qualitative and quantitative assessment of studies addressing primary multicystic ameloblastoma with regard to treatment and recurrence. Searches were conducted of the Ovid Medline and Embase databases for articles published up to...περισσότερα »
Implant-retained auricular prostheses
Implant-retained auricular prostheses: a clinical challenge Microtia, malformation, deformity, and partial or complete loss of the pinna may be due to various congenital or acquired factors. In adult patients, surgical reconstruction of the missing pinna is difficult and the results are often far from satisfactory. An implant-retained auricular prosthesis is a suitable alternative. A retrospective study of eight patients treated with implant-retained auricular prostheses was performed. For each missing pinna, three titanium implants were placed in the temporal bone. After 6 month... περισσότερα »
Can frozen section be used to assess depth of invasion of early carcinoma of tongue?
Can frozen section be used to assess depth of invasion of early carcinoma of tongue?: We read with great interest the article by Kumar et al. on ‘can frozen section be used to assess depth of invasion of early carcinoma of tongue’ [1]. Authors have compared depth of invasion on frozen section with formalin fixed sections. It is concluded that frozen section analysis is accurate to measure depth of invasion of carcinoma of the tongue and decision to do elective neck dissection may be based on this.
Vertical dimension of occlusion (VDO)
Vertical dimension of occlusion (VDO): cephalometric norms for a Moroccan population: Abstract ObjectivesThe purpose of this work was to develop cephalometric standards of the vertical dimension of occlusion (VDO) in Moroccan adults. MethodsOur data consisted of standardized lateral cephalometric radiographs of 98 students at the Casablanca Faculty of Dentistry. These included 74 women and 24 men aged 18–34 years, who were selected on the basis of a well-proportioned face, acceptable profile, Class I occlusion, minor or no crowding, and no history of orthodontic treatment. Mean...περισσότερα »
Class III dentoskeletal disharmony
Comparisons of two protocols for the early treatment of Class III dentoskeletal disharmony: Objective: To assess the short-term outcomes of splints, Class III elastics, and chincup (SEC III) and rapid maxillary expansion and facial mask (RME/FM) protocols. Materials and methods: 25 patients with Class III dentoskeletal disharmony (10 males, 15 females) treated with the SEC III protocol were evaluated at the beginning (T1, mean age 7.5±1.4 years) and at the end of treatment (T2, mean age 8.7±1.4 years). The SEC III group was compared to a matched sample of 32 Class III patients (16... περισσότερα »
Associations of Dietary Long-Chain {omega}-3 Polyunsaturated Fatty Acids and Fish Consumption With Endometrial Cancer Risk in the Black Women's Health Study
Dietary long-chain (LC) -3 polyunsaturated fatty acids (PUFAs), which derive primarily from intakes of fatty fish, are thought to inhibit inflammation and de novo estrogen synthesis. This study prospectively examined the associations of dietary LC -3 PUFAs and fish with endometrial cancer risk in 47,602 African-American women living in the United States, aged 21–69 years at baseline in 1995, and followed them until 2013 (*n* = 282 cases). Multivariable-adjusted Cox regression models estimated hazard ratios and 95% confidence intervals for associations of LC -3 PUFA (quintiled) and... περισσότερα »
Salivary lactobacilli (LB) and mutans streptococci (MS)
Effect of the probiotic bacterium Lactobacillus reuteri on white spot lesion development in orthodontic patients: Background/objectives: The purpose of the study is to evaluate the effect of daily intake of lozenges containing probiotic bacteria on white spot lesion (WSL) formation as well as on salivary lactobacilli (LB) and mutans streptococci (MS) counts, in patients undergoing orthodontic treatment with fixed appliances. Materials/methods: A randomized double-blind placebo-controlled study design with two parallel arms was employed. Patients (*n* = 85, mean age 15.9 years) wit... περισσότερα »
The cervical vertebrae maturation (CVM) method cannot predict craniofacial growth in girls with Class II malocclusion
The cervical vertebrae maturation (CVM) method cannot predict craniofacial growth in girls with Class II malocclusion: Introduction: The cervical vertebrae maturation (CVM) method is used to determine the timing of treatment of Class II malocclusion. Because its performance has not been tested in patients with Class II, the objective of this study was to evaluate the effectiveness of the CVM method in predicting craniofacial growth in Class II malocclusion. Methods: Twenty-nine untreated girls with Class II malocclusion were identified among participants of the Nijmegen Growth St... περισσότερα »
Mandibular and statural growth
New perspectives on the relationship between mandibular and statural growth: Background: Condylar and somatic growth have similar growth curves. The aim of this study was to compare both growth curves in untreated subjects at different ages and investigate if a correlation factor (CF) could be established. Material and methods: Semi-longitudinal records (cephalograms and body height) of 418 untreated, healthy children (193 girls and 225 boys) from a craniofacial growth study were analyzed. Incremental changes of three mandibular measurements from articulare and three from condylion...περισσότερα »
Erratum to: Surgical robotics beyond enhanced dexterity instrumentation: a survey of machine learning techniques and their role in intelligent and autonomous surgical actions
from #Imaging via alexandrossfakianakis on Inoreader http://ift.tt/1mSQ8bn via IFTTT
Robot-assisted automatic ultrasound calibration
Abstract *Purpose* Ultrasound (US) calibration is the process of determining the unknown transformation from a coordinate frame such as the robot's tooltip to the US image frame and is a necessary task for any robotic or tracked US system. US calibration requires submillimeter-range accuracy for most applications, but it is a time-consuming and repetitive task. We provide a new framework for automatic US calibration with robot assistance and without the need for temporal calibration. Method US calibration based on active echo (AE) phantom was previously proposed, and its superior... περισσότερα »
Future therapies for pemphigus vulgaris: Rituximab and beyond
The conventional treatment for patients with pemphigus vulgaris (PV) centers on global immunosuppression, such as the use of steroids and other immunosuppressive drugs, to decrease titers of antidesmoglein autoantibodies responsible for the acantholytic blisters. Global immunosuppressants, however, cause serious side effects. The emergence of anti-CD20 biologic medications, such as rituximab, as an adjunct to conventional therapy has shifted the focus to targeted destruction of autoimmune B cells. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/22WIkFR via ... περισσότερα »
The cervical vertebrae maturation staging method
The reliability of clinical decisions based on the cervical vertebrae maturation staging method: Objectives: Of the various techniques used to determine the optimum timing for growth modification treatments, the cervical vertebrae maturation method has great advantages, including validity and no need for extra X-ray exposure. Recently, the reproducibility of this method has been questioned. The aim of this study was to investigate the cause of poor reproducibility of this method and to assess the reproducibility of the clinical decisions made based on it. Materials/Methods: Seve... περισσότερα »
Type 2 diabetics with periodontitis
Nonsurgical periodontal therapy with/without diode laser modulates metabolic control of type 2 diabetics with periodontitis: a randomized clinical trial: AbstractIn order to evaluate whether nonsurgical periodontal treatment with/without diode laser (DL) decontamination improves clinical parameters, the levels of IL-1β, IL-6, IL-8, intercellular adhesion molecule (ICAM), and vascular cell adhesion molecule (VCAM) in gingival crevicular fluid and metabolic control (HbA1c) in chronic periodontitis (CP) patients with diabetes mellitus type 2 (DM2). Sixty patients with DM2 and CP were ... περισσότερα »
The use of low-level laser therapy for controlling the gag reflex in children during intraoral radiography
The use of low-level laser therapy for controlling the gag reflex in children during intraoral radiography: AbstractThe current literature suggests that low-level laser stimulation of the PC 6 acupuncture points may prevent gagging. This study aimed to determine if low-level laser therapy (LLLT) can reduce the gag reflex in children undergoing intraoral maxillary radiography. This randomized, controlled, double-blind clinical trial was conducted with 25 children with moderate-to-very severe gag reflexes who required bilateral periapical radiographic examination of the maxillary mol... περισσότερα »
Risk indicators for Peri-implantitis
Risk indicators for Peri-implantitis. A cross-sectional study with 916 implants: Abstract Objectives The aim of this study was to identify systemic and local risk indicators associated with peri-implantitis. Material and methods One hundred eighty-three patients treated with 916 osseointegrated titanium implants, in function for at least 1 year, were included in the present study. The implants were installed at the Foundation for Scientific and Technological Development of Dentistry (FUNDECTO) - University of Sao Paulo (USP) - from 1998 to 2012. Factors related to patient's systemic... περισσότερα »
Long-term outcomes of osteotome sinus floor elevation without bone grafts: a clinical retrospective study of 4–9 years
Long-term outcomes of osteotome sinus floor elevation without bone grafts: a clinical retrospective study of 4–9 years: Abstract Objective To evaluate the long-term clinical and radiographic outcomes of dental implant placed using osteotome sinus floor elevation (OSFE) without bone grafts, and to analyze the potential influence factors of implant survival and endo-sinus bone remodeling. Material and Methods A retrospective study design was adopted. The clinical and radiographic data of 96 implants in 80 patients were collected after 4–9 (mean 5.40) years follow-up. Implant failures,... περισσότερα »
Effects of a collagen membrane positioned between augmentation material and the sinus mucosa in the elevation of the maxillary sinus floor. An experimental study in sheep
Effects of a collagen membrane positioned between augmentation material and the sinus mucosa in the elevation of the maxillary sinus floor. An experimental study in sheep: [image: cover.gif?v=1&s=2eb91ab0c0aac4a9489c87d3] Abstract Objective To assess the influence of a collagen membrane placed subjacent to a pristine sinus mucosa on the healing outcome of a sinus floor elevation procedure. Materials and Methods Eight Pelibuey sheep (Cubano rojo) underwent sinus floor elevation on both sides of the maxilla. At a randomly selected side (test), a collagen membrane was placed subjac... περισσότερα »
Hyperarticulation in speech: Global coordination of the jaw, lips and the tongue
Hyperarticulation in Lombard speech: Global coordination of the jaw, lips and the tongue: Over the last century, researchers have collected a considerable amount of data reflecting the properties of Lombard speech, i.e., speech in a noisy environment. The documented phenomena predominately report effects on the speech signal produced in ambient noise. In comparison, relatively little is known about the underlying articulatory patterns of Lombard speech, in particular for lingual articulation. Here the authors present an analysis of articulatory recordings of speech material in babb... περισσότερα »
Warm Monothermal Caloric Screening
Monothermal Caloric Screening to Improve Healthcare Value.: Objectives: To evaluate whether monothermal caloric screening can reduce the number of caloric irrigations required in the vestibular testing battery while maintaining diagnostic accuracy. Design: Prospective controlled cohort study. Three hundred and ninety patients referred for vestibular testing at this tertiary referral health system over a 1-year period were evaluated; 24 patients met exclusion or failure criteria and 366 patients were included in the study. Population was 35.6% male; average age was 50.4 years old. Eac... περισσότερα »
Reduction in Spread of Excitation from Current Focusing at Multiple Cochlear Locations
Reduction in Spread of Excitation from Current Focusing at Multiple Cochlear Locations in Cochlear Implant Users via Hearing Research Publication date: Available online 8 January 2016 *Source:*Hearing Research Author(s): Monica Padilla, David M. Landsberger Channel interaction from a broad spread of excitation is likely to be a limiting factor in performance by cochlear implant users. Although partial tripolar stimulation has been shown to reduce spread of excitation, the magnitude of the reduction is highly variable across subjects. Because the reduction in spread of excitation is typ... περισσότερα »
Auditory and visual 3D virtual reality therapy as a new treatment for chronic subjective tinnitus
: results of a randomized controlled trial via Hearing Research Publication date: Available online 8 January 2016 *Source:*Hearing Research Author(s): D. Malinvaud, A. Londero, R. Niarra, Ph Peignard, O. Warusfel, I. Viaud-Delmon, G. Chatellier, P. Bonfils BackgroundSubjective tinnitus (ST) is a frequent audiologic condition that still requires effective treatment. This study aimed at evaluating two therapeutic approaches: Virtual Reality (VR) immersion in auditory and visual 3D environments and Cognitive Behaviour Therapy (CBT).Methodsthis open, randomized and therapeutic equivalence ...περισσότερα »
The Role of Lymphocyte to Monocyte Ratio, Microvessel Density and HiGH CD44 Tumor Cell Expression in Non Hodgkin Lymphomas
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Abstract Prognostic significance of immune microenvironment has been emphasized using the most advanced analysis, with consecutive attempts to reveal prognostic impact of this findings. The aim of this study was to compare and define prognostic significance of clinical parameters, microvessel density (MVD) in tumour tissue and expression of CD44s as adhesive molecule on tumour cells in diffuse large B cell lymphoma-DLBCL, primary central nervous system DLBCL-CNS DLBCL and follicular lymphoma-FL. A total of 202 histopathological samples (115 DLBCL/65 FL/22 CNS DLBCL) were evaluated.... περισσότερα »
Multilevel cervical myelopathy due to cervical spondylosis/ossification of posterior longitudinal ligament—A complex problem
*Natarajan Muthukumar* Neurology India 2016 64(1):19-22 from Neurology via xlomafota13 on Inoreader http://ift.tt/1Rjmc4J via IFTTT
An uncommon meningitis in an immunocompetent individual
*Satish P Nirhale, Piyush Ostwal, Prajwal Rao, Pravin Naphade* Neurology India 2016 64(1):168-171 from Neurology via xlomafota13 on Inoreader http://ift.tt/1Rjmc4E via IFTTT
Functional and radiological outcome in patients undergoing a three-level corpectomy for multilevel cervical spondylotic myelopathy and ossified posterior longitudinal ligament
*Dilip K Sengupta* Neurology India 2016 64(1):23-24 from Neurology via xlomafota13 on Inoreader http://ift.tt/1TRsIxi via IFTTT
N-acetyl aspartate peak in extra-axial extraosseous chondrosarcoma of the brain on MRI: Unravelling a diagnostic dilemma
*Sunitha P Kumaran, Zarina Abdul Assis, Sanjaya Viswamitra, Nandita Ghosal, Sai Kiran Narayanam* Neurology India 2016 64(1):176-178 from Neurology via xlomafota13 on Inoreader http://ift.tt/1Zp6ycI via IFTTT
The time-invariant assumption.Selective processing of auditory evoked responses with iterative-randomized stimulation and averaging
Selective processing of auditory evoked responses with iterative-randomized stimulation and averaging: A strategy for evaluating the time-invariant assumption via Hearing Research Publication date: Available online 8 January 2016 *Source:*Hearing Research Author(s): Joaquin T. Valderrama, Angel de la Torre, Carlos Medina, Jose C. Segura, A. Roger D. Thornton The recording of auditory evoked potentials (AEPs) at fast rates allows the study of neural adaptation, improves accuracy in estimating hearing threshold and may help diagnosing certain pathologies. Stimulation sequences used to r...περισσότερα »
Overground and treadmill walking in children with cerebral palsy
Biomechanical and perceived differences between via Gait & Posture Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Taeyou Jung, Yumi Kim, Luke E. Kelly, Mark F. Abel The treadmill is widely used as an instrument for gait training and analysis. The primary purpose of this study was to compare biomechanical variables between overground and treadmill walking in children with cerebral palsy (CP). Perceived differences between the two walking modes were also investigated by comparing self-selected walking speeds. Twenty children with CP performed both overground ... περισσότερα »
Attention during tests of static and anticipatory postural control
Threat-induced changes in via Gait & Posture Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Martin Zaback, Mark G. Carpenter, Allan L. Adkin Postural threat, manipulated through changes in surface height, influences postural control. Evidence suggests changes in attention may contribute to this relationship. However, limited research has explored where and how attention is reallocated when threatened. The primary aim of this study was to describe changes in attention when presented with a postural threat, while a secondary aim was to explore associations be... περισσότερα »
Neurosensory Symptom Complexes after Acute Mild Traumatic Brain Injury
Neurosensory Symptom Complexes after Acute Mild Traumatic Brain Injury: by Michael E. Hoffer, Mikhaylo Szczupak, Alexander Kiderman, James Crawford, Sara Murphy, Kathryn Marshall, Constanza Pelusso, Carey Balaban Mild Traumatic Brain Injury (mTBI) is a prominent public health issue. To date, subjective symptom complaints primarily dictate diagnostic and treatment approaches. As such, the description and qualification of these symptoms in the mTBI patient population is of great value. This manuscript describes the symptoms of mTBI patients as compared to controls in a larger study d...περισσότερα »
An examination of the different ways that non-native phones may be perceptually assimilated as uncategorized
An examination of the different ways that non-native phones may be perceptually assimilated as uncategorized: This study examined three ways that perception of non-native phones may be uncategorized relative to native (L1) categories: focalized (predominantly similar to a single L1 category), clustered (similar to > 2 L1 categories), and dispersed (not similar to any L1 categories). In an online study, Egyptian Arabic speakers residing in Egypt categorized and rated all Australian English vowels. Evidence was found to support focalized, clustered, and dispersed uncategorized assimi... περισσότερα »
Mandarin Tone and Vowel Recognition in Cochlear Implant Users
Mandarin Tone and Vowel Recognition in Cochlear Implant Users: Effects of Talker Variability and Bimodal Hearing.: Objectives: For cochlear implant (CI) users with residual low-frequency acoustic hearing in the nonimplanted ear, bimodal hearing combining the use of a CI and a contralateral hearing aid (HA) may provide more salient talker voice cues than CI alone to handle the variability of talker identity across trials. This study tested the effects of talker variability, bimodal hearing, and their interaction on response accuracy and time of CI users' Mandarin tone, vowel, and syll... περισσότερα »
Use of pulsed dye laser treatments in patients with vocal fold mucosal bridges with sulcus vocalis-our experience of five cases
Use of pulsed dye laser treatments in patients with vocal fold mucosal bridges with sulcus vocalis-our experience of five cases: Abstract Larger and thicker mucosal bridges are usually associated with severe dysphonia, surgical excision is the currently preferred treatment. Surgical excision of mucosal bridges may decrease vocal fold bulk and result in subsequent postoperative glottal incompetence. PDL can make a cleavage plane between the epithelium and the superficial lamina propria by denaturing the anchoring fibers of lamina lucida of the basement membrane, and this plane allows ...περισσότερα »
Sinonasal undifferentiated carcinoma (SNUC) : Targeting HER2 may be a promising avenue
Human epidermal growth factor receptor 2/neu as a novel therapeutic target in sinonasal undifferentiated carcinoma: Abstract Background Sinonasal undifferentiated carcinoma (SNUC) is a rare and aggressive cancer. Despite multimodal therapy, the prognosis in SNUC remains poor, and new therapies are needed. Thus, the purpose of this study was to explore potential therapeutic targets in SNUC. Methods Using the human-derived SNUC MDA8788-6 cell line, we performed whole genome single nucleotide polymorphism (SNP) analysis to identify copy number changes in this line. Protein expression l... περισσότερα »
Human epidermal growth factor receptor 2/neu as a novel therapeutic target in sinonasal undifferentiated carcinoma
Human epidermal growth factor receptor 2/neu as a novel therapeutic target in sinonasal undifferentiated carcinoma: Abstract Background Sinonasal undifferentiated carcinoma (SNUC) is a rare and aggressive cancer. Despite multimodal therapy, the prognosis in SNUC remains poor, and new therapies are needed. Thus, the purpose of this study was to explore potential therapeutic targets in SNUC. Methods Using the human-derived SNUC MDA8788-6 cell line, we performed whole genome single nucleotide polymorphism (SNP) analysis to identify copy number changes in this line. Protein expression l... περισσότερα »
Assessment of functional outcomes of temporalis muscle transfers for patients with longstanding facial paralysis
Assessment of functional outcomes of temporalis muscle transfers for patients with longstanding facial paralysis: Abstract Background Usually, clinical evaluation of facial reanimation provides accurate information about contraction of the mimetic muscles and phonation but fails to identify smile recovery and to quantify the motility of the lower third of the face during a smile. The purpose of this study was to verify that, in longstanding facial palsy, the modified temporalis muscle transfer (MTMT) can result in the ability to smile, not only voluntarily with chewing, but also sp... περισσότερα »
Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma
Significance of TNF-α and the Adhesion Molecules: L-Selectin and VCAM-1 in Papillary Thyroid Carcinoma: Circulating levels of TNF-α and the adhesion molecules L-Selectin and VCAM-1 as well as their expression in the primary tumors of patients with benign thyroid diseases and papillary thyroid carcinoma (PTC) have been determined in this study. The serum levels of TNF-α, L-Selectin, and VCAM-1 were significantly higher in patients with both benign thyroid diseases and PTC as compared to the healthy individuals. However, the levels of only TNF-α and L-Selectin, and not VCAM-1, were si...περισσότερα »
Afatinib and Postoperative Radiation Therapy to Treat Head and Neck Cancer
Safety Study of Afatinib and Postoperative Radiation Therapy to Treat Head and Neck Cancer: *Condition*: Squamous Cell Carcinoma of the Head and Neck *Interventions*: Drug: Afatinib; Drug: Docetaxel; Radiation: Radiation Therapy *Sponsors*: Dana-Farber Cancer Institute; National Comprehensive Cancer Network This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational drug. Phase I studies also try to define the appropriate dose of the investigational drug to use for further studies. "Investigational" means that the dru... περισσότερα »
Establishing Lymphedema and Fibrosis Measures in Oral Cancer Patients
Establishing Lymphedema and Fibrosis Measures in Oral Cancer Patients: *Conditions*: Oral Cavity Cancer; Oropharyngeal Cancer; Lymphedema; Fibrosis *Interventions*: Other: LEF measures; Procedure: Technical measure; Procedure: Technical measure *Sponsors*: Vanderbilt-Ingram Cancer Center; National Cancer Institute (NCI); National Institute of Dental and Craniofacial Research (NIDCR) This four-year, prospective, longitudinal study will evaluate and validate a patient-reported outcome measure, clinician-reported outcome measures, and imaging techniques in asses... περισσότερα »
Ultrasound Guided Intermediate Cervical Plexus Block for Congenital Muscular Torticollis
Ultrasound Guided Intermediate Cervical Plexus Block for Congenital Muscular Torticollis: *Condition*: Congenital Muscular Torticollis *Interventions*: Other: intermediate cervical plexus block; Drug: Fentanyl; Drug: Ibuprofen *Sponsor*: Ajou University School of Medicine Congenital Muscular Torticollis (CMT) is a postural deformity of head and neck detected at birth or shortly after birth, primarily resulting from unilateral shortening of Sternocleidomastoid Muscle (SCM). Surgery could be chosen for the treatment for some children, which is accompanied by moderate pain... περισσότερα »
Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management
Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management: AbstractMore than 120,000 patients are treated annually in Germany to resolve repeated episodes of acute tonsillitis. Therapy is aiming at symptom regression, avoidance of complications, reduction in the number of disease-related absences in school or at work, increased cost-effectiveness and improved quality of life. The purpose of this part of the guideline is to provide clinicians in any setting with a clinically focused multi-disciplinary guidance through different conservative treatment option... περισσότερα »
Perspectives in chemosensitivity and chemoresistance assays and their implementation in head and neck cancer
Perspectives in chemosensitivity and chemoresistance assays and their implementation in head and neck cancer: AbstractTherapeutic options for patients with head and neck squamous cell carcinoma include surgery, radiation and chemotherapy. The latter plays a major role in the treatment selection of recurrent, metastatic or therapy resistant tumours, these being some of the major challenges in head and neck oncology. For these patients, chemosensitivity and chemoresistance assays would be paramount to identify their individual therapy options. In this review, seven common assays will... περισσότερα »
Electrically evoked compound action potential (ECAP) in cochlear implant children
Article in Press Electrically evoked compound action potential (ECAP) in cochlear implant children: Changes in auditory nerve response in first year of cochlear implant use - Abstract - Full Text - Images - References - PDF (153 KB) - Download Images(.ppt)About Images & Usage - Email Article - Add to My Reading List - Export Citation - Create Citation Alert - Cited by in Scopus (0) Laila M. Telmesani1 , Nithreen M. Said23[image: correspondence][image: email] 1Professor/Laila Mohammed Al Telmesani, Professor of Otorhinolaryngology, Consultant Otolog... περισσότερα »
Construction and identification of small hairpin RNA plasmids targeting neuropilin-1 gene and their inhibitory effect on human nasopharyngeal carcinoma CNE-2Z cell proliferation in vitro and in vivo
Construction and identification of small hairpin RNA plasmids targeting neuropilin-1 gene and their inhibitory effect on human nasopharyngeal carcinoma CNE-2Z cell proliferation in vitro and in vivo: AbstractWe observed the effects of small hairpin RNA (shRNA) plasmids targeting *neuropilin*-*1* (*NRP*-*1*) gene on human nasopharyngeal carcinoma (NPC) CNE-2Z cell growth in vitro and in vivo. Three fluorescein-labeled shRNA eukaryotic expression vectors targeting *NRP*-*1* gene, including pSilencer-shRNA1, pSilencer-shRNA2 and pSilencer-shRNA3 were constructed. The three plasmids we...περισσότερα »
Cervical Lymphadenopathies in Children
Cervical Lymphadenopathies in Children: A Prospective Clinical Cohort Study: Cervical lymphadenopathy (LAP) is a common sign and may raise fears about serious illnesses. The aim of our study was to evaluate the patients with cervical LAPs in a general pediatrics clinic setting, and to evaluate follow-up results for potential causes and risk factors for malignancies. AbstractAim Cervical lymphadenopathy (LAP) is a common sign and may raise fears about serious illnesses. The aim of our study was to evaluate the patients with cervical LAPs in a general pediatrics clinic setting, and ...περισσότερα »
Tracheobronchomegaly associated with laryngo-tracheal amyloidosis
Article in Press : First case report - Abstract - Full Text - Images - References - PDF (1 MB) - Download Images(.ppt)About Images & Usage - Email Article - Add to My Reading List - Export Citation - Create Citation Alert - Cited by in Scopus (0) Kazuo Adachi[image: correspondence][image: email] , Toshiro Umezaki , Shizuo Komune Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan *Auris Nasus Larynx* Received: November 11, 2015; Accepted: December 23, 2015; Pu... περισσότερα »
Electrical Stimulation to Enhance Axon Regeneration After Peripheral Nerve Injuries in Animal Models and Humans
Abstract Injured peripheral nerves regenerate their lost axons but functional recovery in humans is frequently disappointing. This is so particularly when injuries require regeneration over long distances and/or over long time periods. Fat replacement of chronically denervated muscles, a commonly accepted explanation, does not account for poor functional recovery. Rather, the basis for the poor nerve regeneration is the transient expression of growth-associated genes that accounts for declining regenerative capacity of neurons and the regenerative support of Schwann cells over tim... περισσότερα »
HNSCC : The total cfDNA and HPV16/18 detection in plasma samples : A high level of cfDNA is specific for patients with OPSCC
Assessment of the total cfDNA and HPV16/18 detection in plasma samples of head and neck squamous cell carcinoma patients via ScienceDirect Publication: Oral Oncology Publication date: Available online 11 January 2016 *Source:*Oral Oncology Author(s): Agnieszka M. Mazurek, Tomasz Rutkowski, Anna Fiszer-Kierzkowska, Ewa Małusecka, Krzysztof Składowski ObjectivesThe advantages of the circulating cell-free DNA (cfDNA) methodology are quick results and the possibility of repeated analysis. The main aim of our study was to establish the relationship of the total cfDNA with patients’ clinical... περισσότερα »
Atezolizumab, an Anti-Programmed Death-Ligand 1 Antibody, in Metastatic Renal Cell Carcinoma: Long-Term Safety, Clinical Activity, and Immune Correlates From a Phase Ia Study Urologic Oncology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Purpose The objective was to determine the safety and clinical activity of atezolizumab (MPDL3280A), a humanized programmed death-ligand 1 (PD-L1) antibody, in renal cell carcinoma (RCC). Exploratory biomarkers were analyzed and associated with outcomes. Patients and Methods Seventy patients with metastatic RCC, including clear cell (ccRCC; n = 63) and non–clear cell (ncc; n = […]
Building a Rapid Learning Health Care System for Oncology: Why CancerLinQ Collects Identifiable Health Information to Achieve Its Vision SPECIAL ARTICLE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
The ever-increasing volume of scientific discoveries, clinical knowledge, novel diagnostic tools, and treatment options juxtaposed with rising costs in health care challenge physicians to identify, prioritize, and use new information rapidly to deliver efficient and high-quality care to a growing and aging patient population. CancerLinQ, a rapid learning health care system in oncology, is an […]
Mantle Cell Lymphoma REVIEW ARTICLES
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Mantle cell lymphoma (MCL) is an uncommon subtype of non-Hodgkin lymphoma previously considered to have a poor prognosis. Large gains were made in the first decade of the new century when clinical trials established the importance of high-dose therapy and autologous stem-cell rescue and high-dose cytarabine in younger patients and the benefits of maintenance rituximab […]
Reply to G.B. Holt CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
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Auris Nasus Larynx
Tracheobronchomegaly associated with laryngo-tracheal amyloidosis: First case report Tracheobronchomegaly (TBM) is a rare enlargement of the tracheal cartilage, also known as Mounier-Kuhn syndrome (MKS). Here, we describe an unusual case of acquired TBM in an adult, caused by amyloid regeneration and associated tracheal weakening, rather than by MKS. CT scan and fiberscopic examination of a 55-year-old woman suffering from severe dyspnea revealed TBM and subglottic stenosis, which was caused by deposition of amyloid tissue. We performed a tracheostomy and vaporized the subglottic ste... περισσότερα »
Implant-retained auricular prostheses: a clinical challenge
Microtia, malformation, deformity, and partial or complete loss of the pinna may be due to various congenital or acquired factors. In adult patients, surgical reconstruction of the missing pinna is difficult and the results are often far from satisfactory. An implant-retained auricular prosthesis is a suitable alternative. A retrospective study of eight patients treated with implant-retained auricular prostheses was performed. For each missing pinna, three titanium implants were placed in the temporal bone. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1UKNGxX ... περισσότερα »
Recurrence rate following treatment for primary multicystic ameloblastoma: systematic review and meta-analysis
Opinions regarding the treatment of multicystic ameloblastoma are divergent due to its benign nature and the high rate of recurrence if not adequately excised. The aim of the present study was to perform a systematic review of the literature for a qualitative and quantitative assessment of studies addressing primary multicystic ameloblastoma with regard to treatment and recurrence. Searches were conducted of the Ovid Medline and Embase databases for articles published up to January 2014. Based on predefined eligibility criteria, studies were selected in a two-stage screening proce... περισσότερα »
Nasopharyngeal granulomatous mass after radiotherapy for nasopharyngeal carcinoma
Nasopharyngeal granulomatous mass after radiotherapy for nasopharyngeal carcinoma: To evaluate the diagnosis, management and nasal endoscopic surgical outcome of nasopharyngeal granulomatous mass in post-radiation nasopharyngeal carcinoma (NPC) patients. AbstractObjective To evaluate the diagnosis, management and nasal endoscopic surgical outcome of nasopharyngeal granulomatous mass in post-radiation nasopharyngeal carcinoma (NPC) patients. Materials and methods A total of 23 cases of granulomatous mass after radiotherapy for NPC from 2008 to 2013 treated with nasal endoscopic sur... περισσότερα »
Clinical application of vestibular evoked myogenic potential (VEMP)
Clinical application of vestibular evoked myogenic potential (VEMP): The author reviewed clinical aspects of vestibular evoked myogenic potentials (VEMPs). Now two types of VEMPs are available. The first one is cervical VEMP, which is recorded in the sternocleidomastoid muscle and predominantly reflects sacculo-collic reflex. The other is ocular VEMP, which is usually recorded below the lower eye lid and predominantly reflects utriculo-ocular reflex. VEMPs play important roles not only for assessment of common vestibular diseases but also for establishment of new clinical entities.
The Role of Core-Needle Biopsy as a First-Line Diagnostic Tool for Initially Detected Thyroid Nodules
The Role of Core-Needle Biopsy as a First-Line Diagnostic Tool for Initially Detected Thyroid Nodules: Thyroid , Vol. 0, No. 0. Author information Chong Hyun Suh,1,2 Jung Hwan Baek,1 Jeong Hyun Lee,1 Young Jun Choi,1 Jae Kyun Kim,3 Tae-Yon Sung,4 Jong Ho Yoon,4 and Young Kee Shong5 1Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. 2Department of Radiology, Namwon Medical Center, Namwon-si, Republic of Korea. 3Department of Radiology, Chung-Ang University College of Medicine, Seoul, R... περισσότερα »
BRAFV600E Is Correlated with Recurrence of Papillary Thyroid Microcarcinoma: A Systematic Review, Multi-Institutional Primary Data Analysis, and Meta-Analysis
BRAFV600E Is Correlated with Recurrence of Papillary Thyroid Microcarcinoma: A Systematic Review, Multi-Institutional Primary Data Analysis, and Meta-Analysis: Thyroid , Vol. 0, No. 0. Author information Yufei Chen,1 Peter M. Sadow,2 Hyunsuk Suh,3 Kyu Eun Lee,4 June Young Choi,4 Yong Joon Suh,4 Tracy S. Wang,5 and Carrie C. Lubitz1,6 1Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts. 2Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts. 3Department of Surgery, Mount Sinai Medical Center, New York, New York. 4Department of Surge... περισσότερα »
Evaluation of Autologous Fascia Implantation With Controlled Release of Fibroblast Growth Factor for Recurrent Laryngeal Nerve Paralysis Due to Long-term Denervation
Evaluation of Autologous Fascia Implantation With Controlled Release of Fibroblast Growth Factor for Recurrent Laryngeal Nerve Paralysis Due to Long-term Denervation: Objectives: Paralyzed tissue due to long-term denervation is resistant to many treatments because it induces irreversible histological changes and disorders of deglutition or phonation. We sought to determine the effect of autologous transplantation of fascia into the vocal fold (ATFV) with controlled release of basic fibroblast growth factor (bFGF) on long-term unilateral vocal fold paralysis (UVFP). Methods: Unilat... περισσότερα »
Evaluation of Autologous Fascia Implantation With Controlled Release of Fibroblast Growth Factor for Recurrent Laryngeal Nerve Paralysis Due to Long-term Denervation
Evaluation of Autologous Fascia Implantation With Controlled Release of Fibroblast Growth Factor for Recurrent Laryngeal Nerve Paralysis Due to Long-term Denervation: Objectives: Paralyzed tissue due to long-term denervation is resistant to many treatments because it induces irreversible histological changes and disorders of deglutition or phonation. We sought to determine the effect of autologous transplantation of fascia into the vocal fold (ATFV) with controlled release of basic fibroblast growth factor (bFGF) on long-term unilateral vocal fold paralysis (UVFP). Methods: Unilat... περισσότερα »
Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
Abstract More than 120,000 patients are treated annually in Germany to resolve repeated episodes of acute tonsillitis. Therapy is aiming at symptom regression, avoidance of complications, reduction in the number of disease-related absences in school or at work, increased cost-effectiveness and improved quality of life. The purpose of this part of the guideline is to […]
Circulating Metabolites and Survival Among Patients With Pancreatic Cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
Background: Pancreatic tumors cause changes in whole-body metabolism, but whether prediagnostic circulating metabolites predict survival is unknown. Methods: We measured 82 metabolites by liquid chromatography–mass spectrometry in prediagnostic plasma from 484 pancreatic cancer case patients enrolled in four prospective cohort studies. Association of metabolites with survival was evaluated using Cox proportional hazards models adjusted for […]
NCI-60 Cell Line Screening: A Radical Departure in its Time
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
The year 2015 marked the 30th anniversary of National Cancer Institute’s (NCI’s) initial effort to establish a human cell line panel as the basis for discovering new cancer drugs. At its inception, the NCI-60 panel was a controversial departure, born of frustration with previous efforts that employed murine tumors and grounded in the hope that […]
A Randomized Phase II/III Study of Dalotuzumab in Combination With Cetuximab and Irinotecan in Chemorefractory, KRAS Wild-Type, Metastatic Colorectal Cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1W1YoRY via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Response
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1W1Yn0w via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Non-cardiovascular findings in clinical cardiovascular magnetic resonance imaging in children
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
Abstract Background With increasing use of pediatric cardiovascular MRI, it is important for all imagers to become familiar with the spectrum of non-cardiovascular imaging findings that can be encountered. Objective This study aims to ascertain the prevalence and nature of these findings in pediatric cardiovascular MRIs performed at our institution. Materials and methods We retrospectively […]
Diagnostic paediatric ultrasound (1st edn), by E. Beek and R. R. van Rijn (eds)
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1PTsKnk via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Antenatal and postnatal radiologic diagnosis of holocarboxylase synthetase deficiency: a systematic review
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
Abstract Background Holocarboxylase synthetase deficiency results in impaired activation of enzymes implicated in glucose, fatty acid and amino acid metabolism. Antenatal imaging and postnatal imaging are useful in making the diagnosis. Untreated holocarboxylase synthetase deficiency is fatal, while antenatal and postnatal biotin supplementation is associated with good clinical outcomes. Although biochemical assays are required for […]
Somatotype and Body Composition of Normal and Dysphonic Adult Speakers
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
Voice quality provides information about the anatomical characteristics of the speaker. The patterns of somatotype and body composition can provide essential knowledge to characterize the individuality of voice quality. The aim of this study was to verify if there were significant differences in somatotype and body composition between normal and dysphonic speakers. from #ORL-AlexandrosSfakianakis via […]
Can frozen section be used to assess depth of invasion of early carcinoma of tongue?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα
We read with great interest the article by Kumar et al. on ‘can frozen section be used to assess depth of invasion of early carcinoma of tongue’ [1]. Authors have compared depth of invasion on frozen section with formalin fixed sections. It is concluded that frozen section analysis is accurate to measure depth of invasion […]
The arcTOA technique for out of plane ultrasound-guided injections
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
Out-of-plane (OOP) ultrasound guided injections are often cited as more difficult than in-plane (IP) ultrasound guided injections, particularly for the novice ultrasonographer. In certain circumstances, the OOP approach is required due to the constraints of adjacent anatomical structures. To date, only the "walkdown" approach has been detailed in the literature as a means to improve accuracy with the OOP approach. However, this approach uses a set needle entry angle (angle of incidence) and distance for the injection. from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1TQ... περισσότερα »
Swallowing Training Combined with Game-Based Biofeedback in Post-Stroke Dysphagia
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
For patients with dysphagia due to stroke, in addition to compensatory strategies, exercises are utilized to help improve motor function. Biofeedback is utilized in neuromuscular training, and is promising for swallowing training. from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1Q1gljl via IFTTT
An Analysis of Inpatient Rehabilitation Approval Among Private Insurance Carriers at a Cancer Center
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
Acute inpatient rehabilitation is often utilized by cancer patients to assist with discharge home and/or preparation for further treatment. Private insurance patients often require approval before transfer to acute inpatient rehabilitation. from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1TQXkz5 via IFTTT
Protective role of epigallocatechin-3-gallate in health and disease: A perspective
Publication date: March 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 78 Author(s): Animesh Chowdhury, Jaganmay Sarkar, Tapati Chakraborti, Pijush Kanti Pramanik, Sajal Chakraborti Tea is the most popular beverages all over the world. Polyphenols are found ubiquitously in tea leaves and their regular consumption has been associated with a reduced risk of a number of chronic diseases including cancer, cardiovascular and neurodegenerative diseases. Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in tea leaves and received great attention due to their protective... περισσότερα »
The influence of common free radicals and antioxidants on development of Alzheimer’s Disease
Publication date: March 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 78 Author(s): Karolina A. Wojtunik-Kulesza, Anna Oniszczuk, Tomasz Oniszczuk, Monika Waksmundzka-Hajnos Alzheimer's Disease (AD) is one of the most important neurodegenerative disorders in the 21st century for the continually aging population. Despite an increasing number of patients, there are only few drugs to treat the disease. Numerous studies have shown several causes of the disorder, one of the most important being oxidative stress. Oxidative stress is connected with a disturbance between the levels of... περισσότερα »
Heme oxygenase-1 contributes to imatinib resistance by promoting autophagy in chronic myeloid leukemia through disrupting the mTOR signaling pathway
Publication date: March 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 78 Author(s): Lu Cao, Jishi Wang, Dan Ma, Ping Wang, Yaming Zhang, Qin Fang Heme oxygenase-1 (HO-1) has been verified to play an important role in imatinib (IM)-resistant chronic myeloid leukemia (CML) cells, but the mechanism remains unclear. In drug resistant CML cells, HO-1 expression abnormally increased and that of autophagy-related protein LC-3I/II also increased, so we herein postulated HO-1 was associated with autophagy. HO-1 expressions in IM-sensitive/resistant K562/K562R cells were regulated throu... περισσότερα »
Possible involvement of l-arginine–nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant-like effect of Wuling mycelia powder in rat
Publication date: March 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 78 Author(s): Yun-fei Tan, Zheng-luan Liao, Ya-ju Qiu, Jun-peng Zhu, En-yan Yu ContextWuling mycelia powder is the dry powder of rare a fungi Xyla ria sp., Carbon species, with a long history of medicinal use in Chinese medicine. Recently it has shown a powerful antidepressant activity in clinic.ObjectiveThe present study explores the antidepressant activity of Wuling mycelia powder in chronic unpredictable mild stress (CUMS) rats and its possible involvement of l-arginine–nitric oxide (NO)-cyclic guanosine ...περισσότερα »
The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System
[image: image]In November, 2014, 65 prostate cancer pathology experts, along with 17 clinicians including urologists, radiation oncologists, and medical oncologists from 19 different countries gathered in a consensus conference to update the grading of prostate cancer, last revised in 2005. The major conclusions were: (1) Cribriform glands should be assigned a Gleason pattern 4, regardless of morphology; (2) Glomeruloid glands should be assigned a Gleason pattern 4, regardless of morphology; (3) Grading of mucinous carcinoma of the prostate should be based on its underlying growth p... περισσότερα »
Atypical Renal Cysts: A Morphologic, Immunohistochemical, and Molecular Study
[image: image]There is a lack of standardized nomenclature for renal cysts lined by multiple cell layers or with short papillary projections but without nests of epithelial cells within the stroma. We retrieved 29 cases (15 nephrectomies, 14 partial nephrectomies) from the surgical pathology files of Johns Hopkins Hospital from 1993 to 2014 and performed immunohistochemistry for CK7, alpha-methylacyl-CoA racemase (AMACR), CAIX, and CD10 and fluorescence in situ hybridization for trisomy 7 and 17 and 3p deletion. The mean age at excision was 58 years (range, 29 to 80 y) with 16 men a... περισσότερα »
Invasive Stratified Mucin-producing Carcinoma and Stratified Mucin-producing Intraepithelial Lesion (SMILE): 15 Cases Presenting a Spectrum of Cervical Neoplasia With Description of a Distinctive Variant of Invasive Adenocarcinoma
[image: image]Stratified mucin-producing intraepithelial lesion (SMILE) is a cervical intraepithelial lesion, distinct from conventional squamous or glandular counterparts, believed to arise from embryonic cells at the transformation zone by transdifferentiation during high-risk HPV-associated carcinogenesis. It is characterized by stratified, immature epithelial cells displaying varying quantities of intracytoplasmic mucin throughout the majority of the lesional epithelium. We identified a distinct form of invasive cervical carcinoma with morphologic features identical to those in ... περισσότερα »
Thoracic Myoepithelial Tumors: A Pathologic and Molecular Study of 8 Cases With Review of the Literature
[image: image]Thoracic myoepithelial tumors (MTs) are a rare group of tumors showing predominant or exclusive myoepithelial differentiation. They are poorly characterized from both a morphologic and genetic standpoint, in particular features that separate benign from malignant behavior. We examined the histologic and immunohistochemical features of 8 primary thoracic MTs and performed fluorescence in situ hybridization for EWSR1, FUS, PLAG1, and HMGA2, as well as several partner genes. Half (4/8) of the MTs occurred in large airways, and 3 had infiltrative borders. All cases showed ...περισσότερα »
Combined “Infiltrating Astrocytoma/Pleomorphic Xanthoastrocytoma” Harboring IDH1 R132H and BRAF V600E Mutations
[image: image]Pleomorphic xanthoastrocytoma (PXA) has rarely been reported in combination with infiltrating glioma, historically interpreted as a "collision tumor." Isocitrate dehydrogenase 1 (IDH1) and BRAF V600E mutations are usually not concurrent. The former is typical of adult infiltrating gliomas, and the latter is identified in a variety of primary central nervous system neoplasms, including PXA, ganglioglioma, pilocytic astrocytoma, and rarely infiltrating gliomas. We report the case of a 56-year-old man presenting with seizures and headaches. Magnetic resonance imaging reve... περισσότερα »
Oral appliance in sleep apnea treatment: respiratory and clinical effects and long-term adherence
Abstract Purpose There is an increasing tendency to use oral appliance (OA) as an alternative treatment for sleep apnea. Here we report the long-term adherence and clinical effects of OA therapy. Methods All sleep apnea patients treated at the Department of Dentistry between the years 2006 and 2013 (*n* = 1208) were reviewed. A questionnaire about OA adherence, asthma symptoms (Asthma Control Test™, ACT), and general health was sent to all patients who continued OA therapy after the 1-month follow-up visit (*n* = 811). OA was adjusted to obtain at least 70 % of the maximal protru...περισσότερα »
Reply to letter inflammatory markers in patients with obstructive sleep apnea
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Inflammatory markers in patients with obstructive sleep apnea
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Innate Immunity and BK Virus: Prospective Strategies
Viral Immunology , Vol. 0, No. 0. from Allergy\Immunology via ola Kala on Inoreader http://ift.tt/1P60oTA via IFTTT
Phenotyping asthma in the elderly: allergic sensitization profile and upper airways comorbidity in patients older than 65 years
Publication date: Available online 11 January 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Carlo Lombardi, Elena Raffetti, Marco Caminati, Gennaro Liccardi, Gianni Passalacqua, Federico Reccardini, Erminia Ridolo, GianEnrico Senna, Gundi Steinhilber, M. Milanese BackgroundData about allergic rhinitis in elderly patients with asthma are lacking.ObjectiveTo investigate the presence of rhinitis and the role of sensitization of airborne allergens in elderly patients with asthma.MethodsThis was a multicenter cross-sectional study involving subjects at least 65 years ol... περισσότερα »
Allergy-immunology practice parameters and strength of recommendation data: an evolutionary perspective
Publication date: Available online 11 January 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Matthew H. Park, Taylor A. Banks, Michael R. Nelson BackgroundThe practice parameters for allergy and immunology (A/I) are a valuable tool guiding practitioners' clinical practice. The A/I practice parameters have evolved over time in the context of evidence-based medicine milestones.ObjectivesTo identify evolutionary trends in the character, scope, and evidence underlying recommendations in the A/I practice parameters.MethodsPractice parameters that have guided A/I from 1995... περισσότερα »
Association between chronic urticaria and self-reported penicillin allergy
Publication date: Available online 11 January 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Susanna Silverman, Russell Localio, Andrea J. Apter BackgroundPenicillin allergy is the most commonly reported drug allergy and often presents with cutaneous symptoms. Other common diagnoses, such as chronic urticaria, may be falsely attributed to penicillin allergy. Because chronic urticaria is fairly common in the general population, evaluation of its prevalence in patients with self-reported penicillin allergy was of interest. Similarly, the prevalence of self-reported pen...περισσότερα »
Letter to the editor: Response to two recent articles regarding achondroplasia
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Pseudodiastrophic dysplasia: Two cases delineating and expanding the pre and postnatal phenotype
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12th international CHARGE syndrome conference proceedings
The CHARGE Syndrome Foundation holds an International conference for families and professionals every other summer. In July, 2015, the 12th meeting was held in Schaumburg, Illinois, at the Renaissance Schaumburg Hotel. Day one of the 4-day conference was dedicated to professionals caring for and researching various aspects of CHARGE, including education, medical management, animal models, and stem cell-based approaches to understanding and treating individuals with CHARGE. Here, we summarize presentations from the meeting, including a synopsis of each of the three different break...περισσότερα »
Interstitial 6q25 microdeletion syndrome: ARID1B is the key gene
Interstitial deletions of the long arm of chromosome 6 are rare. Clinically, these deletions are considered to be part of a unique microdeletion syndrome associated with intellectual disability and speech impairment, typical dysmorphic features, structural anomalies of the brain, microcephaly, and non-specific multiple organ anomalies. The critical region for the interstitial 6q microdeletion phenotype was mapped to 6q24–6q25, particularly the 6q25.3 region containing the genes *ARID1B* and *ZDHHC14*. It has been hypothesized that haploinsufficiency of these genes impairs normal ... περισσότερα »
A novel mutation p.Ser348Cys in FGFR3 causes achondroplasia
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Response: “Best practices in the evaluation and treatment of foramen magnum stenosis in achondroplasia during infancy” and “is there a correlation between sleep disordered breathing and foramen magnum stenosis in children with achondroplasia?”
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Pancreatic Pseudocyst Causing Partial Small Bowel Obstruction and Cholangitis
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 11 January 2016 Source:The Journal of Emergency Medicine Author(s): Casey Wilson, Susan Peterson from Emergencies via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TRasUS via IFTTT
Conceptual Alignment: How Brains Achieve Mutual Understanding
Publication date: Available online 11 January 2016 *Source:*Trends in Cognitive Sciences Author(s): Arjen Stolk, Lennart Verhagen, Ivan Toni We share our thoughts with other minds, but we do not understand how. Having a common language certainly helps, but infants' and tourists' communicative success clearly illustrates that sharing thoughts does not require signals with a pre-assigned meaning. In fact, human communicators jointly build a fleeting conceptual space in which signals are a means to seek and provide evidence for mutual understanding. Recent work has started to capture t...περισσότερα »
The relation of serum uric acid levels with l -Dopa treatment and progression in patients with Parkinson’s disease
Abstract In this study, we aimed to investigate the association of the serum uric acid (UA) level with disease progression and l-Dopa treatment in PD (Parkinson's disease) patients. Serum UA levels of 80 consecutive PD patients were measured and were matched according to age and sex with 80 healthy controls. The patients were divided into two subgroups according to the pharmaceutical treatment received. First group consisted of patients treated with l-Dopa and a dopamine agonist and the second group consisted of patients treated only with a dopamine agonist. The patients were divid...περισσότερα »
Cauda equina syndrome due to large B-cell lymphoma: a case report
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Lack of association between the Angiogenin ( ANG ) rs11701 polymorphism and amyotrophic lateral sclerosis risk: a meta-analysis
Abstract To perform a meta-analysis to help resolve the controversy of whether the *Angiogenin* (*ANG*) rs11701 polymorphism is associated with amyotrophic lateral sclerosis (ALS) risk. A literature search of PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure, Wanfang and SinoMed was conducted for eligible studies published up to Jun 5, 2015. The strength of the association between the polymorphism and ALS susceptibility was estimated by odds ratio (OR) and associated 95 % confidence interval (CI). The pooled ORs were assessed for the dominant model (TG + GG ... περισσότερα »
A rare cause of lymphadenopathy – Rosai-Dorfman disease in a HIV-positive Ugandan woman
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This case illustrates a rare cause of lymphadenopathy as a presenting feature of HIV and highlights the importance HIV testing in all patients who present with lymphadenopathy. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mRXviM via IFTTT
Corrigendum
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Bodies are three-dimensional, and so is Novant’s new mammogram machine – Salisbury Post
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Salisbury Post Bodies are three-dimensional, and so is Novant’s new mammogram machine Salisbury Post Today begins a new era in breast cancer detection, with the area’s first state of the art 3D mammography machine powering up to full operation at Novant Health’s Julian Road Imaging Facility. The new technology, unsurpassed anywhere in the world, is […]
Classical Antiquity
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Classical Antiquity, published by University of California Press, last updated on 2016-01-11, available at http://ca.ucpress.edu from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ca.ucpress.edu/ via IFTTT
Microstructural asymmetry of the corticospinal tracts predicts right–left differences in circle drawing skill in right-handed adolescents
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Most humans show a strong preference to use their right hand, but strong preference for the right hand does not necessarily imply a strong right–left asymmetry in manual proficiency (i.e., dexterity). Here we tested the hypothesis that intra-individual asymmetry of manual proficiency would be reflected in microstructural differences between the right and left corticospinal […]
The white matter query language: a novel approach for describing human white matter anatomy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract We have developed a novel method to describe human white matter anatomy using an approach that is both intuitive and simple to use, and which automatically extracts white matter tracts from diffusion MRI volumes. Further, our method simplifies the quantification and statistical analysis of white matter tracts on large diffusion MRI databases. This work […]
Propagation of spontaneous slow-wave activity across columns and layers of the adult rat barrel cortex in vivo
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract During slow-wave sleep, neocortical networks exhibit self-organized activity switching between periods of concurrent spiking (up-states) and periods of network silence (down-states), a phenomenon also occurring under the effects of different anesthetics and in in vitro brain slice preparations. Although this type of ongoing activity has been implicated into important functions such as memory consolidation […]
‘What About Swallowing?’ Diagnostic Performance of Daily Clinical Practice Compared with the Eating Assessment Tool-10
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract In daily clinical practice, patients are frequently asked about their swallowing as part of the patient-clinician interview. This study compares the diagnostic performance of a single open question ‘What about swallowing?’ (usual care) with the Eating Assessment Tool (EAT-10) as reference test in screening for oropharyngeal dysphagia (OD). 303 outpatients at risk of OD […]
A Meta-Analysis of the Incidence of Patient-Reported Dysphagia After Anterior Cervical Decompression and Fusion with the Zero-Profile Implant System
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Dysphagia is a well-known complication following anterior cervical surgery. It has been reported that the Zero-profile Implant System can decrease the incidence of dysphagia following surgery, however, dysphagia after anterior cervical decompression and fusion (ACDF) with the Zero-profile Implant System remains controversial. Previous studies only focus on small sample sizes. The objective of this […]
Pharyngeal Residue Severity Rating Scales Based on Fiberoptic Endoscopic Evaluation of Swallowing: A Systematic Review
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Identification of pharyngeal residue severity located in the valleculae and pyriform sinuses has always been a primary goal during fiberoptic endoscopic evaluation of swallowing (FEES). Pharyngeal residue is a clinical sign of potential prandial aspiration making an accurate description of its severity an important but difficult challenge. A reliable, validated, and generalizable pharyngeal residue […]
infection induces asthma onset
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The immune system has evolved to allow human subjects to adapt harmoniously to the environment, with the ability to distinguish “self” from “nonself” and to eliminate harmful organisms and substances. Maintaining a state of tolerance for certain antigens is as important as responding with immunity to other antigens. After Edward Jenner (1798) showed the benefits […]
Activated prostaglandin D receptors on macrophages enhance neutrophil recruitment into the lung
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Prostaglandin (PG) D2 is an early-phase mediator in inflammation, but its action and the roles of the 2 D-type prostanoid receptors (DPs) DP1 and DP2 (also called chemoattractant receptor–homologous molecule expressed on TH2 cells) in regulating macrophages have not been elucidated to date. from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OnydQS via IFTTT
Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Sensory nerves innervating the airways play an important role in regulating various cardiopulmonary functions, maintaining homeostasis under healthy conditions and contributing to pathophysiology in disease states. Hypo-osmotic solutions elicit sensory reflexes, including cough, and are a potent stimulus for airway narrowing in asthmatic patients, but the mechanisms involved are not known. Transient receptor potential cation […]
Tellurium as a high-performance elemental thermoelectric
Article Good thermoelectric materials are often complex compounds. Here, the authors reveal that elemental tellurium has a high thermoelectric figure of merit between 300 and 700 K when doped with As, with the potential advantages of easy preparation and relative isotropy. Nature Communications doi: 10.1038/ncomms10287 Authors: Siqi Lin, Wen Li, Zhiwei Chen, Jiawen Shen, Binghui Ge,… Continue reading Tellurium as a high-performance elemental thermoelectric
A Randomized Phase II/III Study of Dalotuzumab in Combination With Cetuximab and Irinotecan in Chemorefractory, KRAS Wild-Type, Metastatic Colorectal Cancer
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1W1YoRY via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OnO4P7 via IFTTT
NCI-60 Cell Line Screening: A Radical Departure in its Time
The year 2015 marked the 30th anniversary of National Cancer Institute’s (NCI’s) initial effort to establish a human cell line panel as the basis for discovering new cancer drugs. At its inception, the NCI-60 panel was a controversial departure, born of frustration with previous efforts that employed murine tumors and grounded in the hope that… Continue reading NCI-60 Cell Line Screening: A Radical Departure in its Time
A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization
Article Synthetic organic fluorophores are powerful tools for bioimaging, but frequently display shortened observation times and signal fluctuations. Here, the authors report a general method to covalently label a biomolecule with a fluorophore and photostabilizer, reducing unwanted photophysical effects by intramolecular quenching of reactive fluorophore states. Nature Communications doi: 10.1038/ncomms10144 Authors: Jasper H. M. van… Continue reading A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization
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from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1W1Yn0w via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OMwWpW via IFTTT
Policing, Community Fragmentation, and Public Health: Observations from Baltimore
Abstract Studies show that policing, when violent, and community fragmentation have a negative impact on health outcomes. This current study investigates the connection of policing and community fragmentation and public health. Using an embedded case study analysis, semi-structured interviews were conducted with 21 African-American female and male residents, ages 21–64 years of various neighborhoods of… Continue reading Policing, Community Fragmentation, and Public Health: Observations from Baltimore
Non-cardiovascular findings in clinical cardiovascular magnetic resonance imaging in children
Abstract Background With increasing use of pediatric cardiovascular MRI, it is important for all imagers to become familiar with the spectrum of non-cardiovascular imaging findings that can be encountered. Objective This study aims to ascertain the prevalence and nature of these findings in pediatric cardiovascular MRIs performed at our institution. Materials and methods We retrospectively… Continue reading Non-cardiovascular findings in clinical cardiovascular magnetic resonance imaging in children
LifeSkills for Men (LS4M): Pilot Evaluation of a Gender-Affirmative HIV and STI Prevention Intervention for Young Adult Transgender Men Who Have Sex with Men
Abstract Young adult transgender men who have sex with men (TMSM) engage in sexual behaviors that place them at risk of sexually transmitted infections (STIs) including HIV. To date, no HIV and STI prevention interventions have been developed specifically for young adult TMSM. To address this gap, the current study aimed to (1) adapt a… Continue reading LifeSkills for Men (LS4M): Pilot Evaluation of a Gender-Affirmative HIV and STI Prevention Intervention for Young Adult Transgender Men Who Have Sex with Men
Diagnostic paediatric ultrasound (1st edn), by E. Beek and R. R. van Rijn (eds)
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1PTsKnk via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OnO2H3 via IFTTT
Novel cycloartane triterpenoid from Cimicifuga foetida ( Sheng ma ) induces mitochondrial apoptosis via inhibiting Raf/MEK/ERK pathway and Akt phosphorylation in human breast carcinoma MCF-7 cells
Abstract Background Cycloartane triterpenoids exhibited anticancer effects. This study aims to identify any potential novel anticancer cycloartane triterpenoids from Cimicifuga foetida L. rhizome (Sheng ma) and the mode of actions. Methods Cycloartane triterpenoids were isolated from the C. foetida rhizome by a series of column chromatography and identified by IR, MS and NMR. Their anticancer… Continue reading Novel cycloartane triterpenoid from Cimicifuga foetida ( Sheng ma ) induces mitochondrial apoptosis via inhibiting Raf/MEK/ERK pathway and Akt phosphorylation in human breast ... περισσότερα »
Structural homology guided alignment of cysteine rich proteins
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: Cysteine rich protein families are notoriously difficult to align due to low sequence identity and frequent insertions and deletions. Results: Here we present an alignment method that ensures homologous cysteines align by assigning a unique 10 amino acid barcode to those identified as structurally homologous by the DALI webserver. The free inter-cysteine regions of […]
Are we over treating Pineal Parenchymal tumour with intermediate differentiation? Assessing the role of localised radiation therapy and literature review
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Pineal Parenchymal tumour with intermediate differentiation (PPTID) is a rare disorder, first classified by World Health Organisation in 2000. There are very few published data available and optimal management is yet to be determined. Management has varied from surgery alone to craniospinal radiotherapy with or without chemotherapy. We present our experience of PPTID treated with […]
How fast can glucose be infused in the perioperative setting?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background How the initial infusion rate of glucose solution should be set to avoid hyperglycemia in the perioperative setting is unclear. Methods Computer simulations were performed based on data from seven studies where the kinetics of glucose was calculated using a one-compartment model. Glucose had been infused intravenously on 44 occasions to volunteers and […]
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medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Information for Readers
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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The 975 nm Diode Laser in the Photothermal Treatment of the Aging and Sagging Face and Neck
Photomedicine and Laser Surgery Jan 2016, Vol. 34, No. 1: 27-35. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1UL0C7d via IFTTT
Chronology of the Use of the Laser Beam in Dentistry, and the State of Postgraduate University Education Programs in this Domain
Photomedicine and Laser Surgery Jan 2016, Vol. 34, No. 1: 1-2. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1TRk5TD via IFTTT
Pancreatic Pseudocyst Causing Partial Small Bowel Obstruction and Cholangitis
Publication date: Available online 11 January 2016 Source:The Journal of Emergency Medicine Author(s): Casey Wilson, Susan Peterson from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TRasUS via IFTTT
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from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1W1Yn0w via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mSQZJf via IFTTT
Pancreatic Pseudocyst Causing Partial Small Bowel Obstruction and Cholangitis
Publication date: Available online 11 January 2016 Source:The Journal of Emergency Medicine Author(s): Casey Wilson, Susan Peterson from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TRasUS via IFTTT
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