An update on myofibromas and myofibromatosis affecting the oral regions with report of 24 new cases

Publication date: Available online 5 April 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Molly Housley Smith, John D. Reith, Donald M. Cohen, Nadim M. Islam, Kimberly T. Sibille, Indraneel Bhattacharyya
ObjectivesMyofibromas are uncommon soft tissue tumors exhibiting considerable histopathologic overlap with other benign and malignant entities. The treatment of lesions arising in the oral cavity is controversial. Herein we present 24 new cases and review the literature.Study DesignA search for oral myofibromas was performed within the archives of the UF Oral Pathology and Surgical Pathology Services (1994-2015). Demographic information and immunohistochemical results were recorded. MEDLINE and Web of Science were searched for cases of myofibroma of the oral cavity and oropharynx in the English-language literature between January 1990 and July 2016. The results were analyzed.Results245 total cases were identified: 24 from our present series and 221 from the literature. The distribution by sex was 54.6% male and 45.4% female, and the mean age was 23.1 years. Only 7 patients had known multiple lesions. Treatment modalities varied greatly. Of those with follow-up information, only 9 cases recurred.ConclusionMyofibromas may resemble several other entities. Because of the potential for multiple (perhaps visceral) lesions and possibility for overtreatment, correct diagnosis is of utmost importance. Cases with minimally invasive treatment are sparse, and no standardized treatment protocol is established. This information should be a priority for future publications.



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